pyrroles and tak-441
pyrroles has been researched along with tak-441 in 8 studies
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Baba, A; Hattori, H; Ishimura, Y; Kondo, S; Miyamoto, M; Nishihara, M; Oguro, Y; Ohashi, T; Sasaki, S; Sato, Y; Shibata, S; Shiokawa, Z; Tanaka, T; Tanaka, Y; Tojo, H; Yamakawa, H; Yamamoto, Y | 1 |
| Asahi, S; Kogame, A; Kondo, T; Miyamoto, M; Prakash, S; Shibata, S; Shyu, WC; Tagawa, Y; Tohyama, K; Tojo, H | 1 |
| Cox, ME; Fazli, L; Ghaffari, M; Gleave, ME; Ibuki, N; Iu, I; Kashiwagi, M; Nakanishi, O; Pandey, M; Tojo, H | 1 |
| Ishii, T; Kondo, S; Matsui, H; Nakashima, K; Ogawa, K; Sasaki, S; Shimizu, Y | 1 |
| Borad, MJ; Bowles, DW; Calvo, E; Curtis, KK; Eckhardt, SG; Faessel, H; Gangolli, E; Goldman, J; Hidalgo, M; Parikh, A; Partyka, J; Rosen, LS; Ryan, DP; Stewart, S; Wirth, LJ | 1 |
| Ishii, T; Matsui, H; Nakayama, M; Ogawa, K; Sasaki, S; Shimizu, Y | 1 |
| Baba, A; Banno, H; Hattori, H; Kondo, S; Miyamoto, M; Ohashi, T; Sasaki, S; Satoh, Y; Shibata, S; Shiokawa, Z; Tanaka, T; Tanaka, Y; Tojo, H; Yamakawa, H; Yamamoto, Y | 1 |
| Nakayama, M; Ogawa, K; Shimizu, Y | 1 |
Trials
1 trial(s) available for pyrroles and tak-441
| Article | Year |
|---|---|
Phase I dose-escalation trial of the oral investigational Hedgehog signaling pathway inhibitor TAK-441 in patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Disease Progression; Female; Gene Expression; Hedgehog Proteins; Humans; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Staging; Neoplasms; Pyridines; Pyrroles; Retreatment; RNA, Messenger; Signal Transduction; Transcription Factors; Treatment Outcome; Zinc Finger Protein GLI1 | 2015 |
Other Studies
7 other study(ies) available for pyrroles and tak-441
| Article | Year |
|---|---|
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Medulloblastoma; Mice; Mice, Nude; Models, Molecular; Molecular Structure; NIH 3T3 Cells; Pyridines; Pyrroles; RNA, Messenger; Signal Transduction; Solubility; Structure-Activity Relationship; Transplantation, Homologous; Zinc Finger Protein GLI1 | 2012 |
Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Gene Expression; Hedgehog Proteins; Humans; Mice; Models, Biological; Neoplasms; Oncogene Proteins; Pyridines; Pyrroles; RNA, Messenger; Skin; Trans-Activators; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2013 |
TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.
Topics: Animals; Antineoplastic Agents; Castration; Cell Line, Tumor; Cell Proliferation; Disease Progression; Hedgehog Proteins; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Paracrine Communication; Prostatic Neoplasms; Pyridines; Pyrroles; Receptors, G-Protein-Coupled; Smoothened Receptor; Tumor Microenvironment; Veratrum Alkaloids; Xenograft Model Antitumor Assays | 2013 |
Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant.
Topics: Anilides; Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Drugs, Investigational; Hedgehog Proteins; HEK293 Cells; Humans; Mice; Mutation; NIH 3T3 Cells; Pyridines; Pyrroles; Receptors, G-Protein-Coupled; Smoothened Receptor | 2014 |
Biochemical characterization of smoothened receptor antagonists by binding kinetics against drug-resistant mutant.
Topics: Anilides; Binding, Competitive; Cell Line; Drug Resistance, Neoplasm; Humans; Kinetics; Mutation; Pyridines; Pyrroles; Radioligand Assay; Receptors, G-Protein-Coupled; Smoothened Receptor; Veratrum Alkaloids | 2015 |
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.
Topics: Animals; Crystallography, X-Ray; Drug Evaluation, Preclinical; Genes, Reporter; Half-Life; Hedgehog Proteins; Humans; Mice; Molecular Conformation; Pyridines; Pyrroles; Signal Transduction; Structure-Activity Relationship | 2015 |
Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.
Topics: Binding, Competitive; Humans; Kinetics; Ligands; Pyridines; Pyrroles; Radioligand Assay; Smoothened Receptor | 2016 |