Page last updated: 2024-08-18

pyrroles and st 679

pyrroles has been researched along with st 679 in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (47.22)18.2507
2000's13 (36.11)29.6817
2010's6 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amico-Roxas, M; Attaguile, G; Caruso, A; Cutuli, VM; De Bernardis, E1
Arrigoni Martelli, E; Bruno, G; Cardace, G; Mancinelli, A; Marzo, A; Morabito, E1
Arrigoni-Martelli, E1
Annunziato, L; di Renzo, G2
Donati, G; Spinazzè, R1
Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP1
Antoci, G; Bianchi, P; Catarci, M; Gossetti, F; La Pinta, M; Nanni, G; Negro, P; Nolfe, G; Sarro, G1
Affinito, P; Colace, G; La Pinta, M; Nappi, C; Nolfe, G; Ruotolo, C1
De Santis, E; La Pinta, M; Nolfe, G1
Alicicco, E; Delfino, M; Kleszczynski, D1
Belogi, L; Mezzadri, CM; Ruco, L; Stopacciaro, A; Tubaro, E1
Tavella, A; Ursini, G1
Dobrilla, G2
Carminati, P; Coppelli, G; Coruzzi, G; Grandi, D; Lo Giudice, P; Longo, A; Morini, G; Pace, S; Pacifici, L; Pisano, C; Vesci, L1
Bertaccini, G; Coruzzi, G1
Arancio, A; Cataldo, T; D'Agata, R; Vicari, E1
Belogi, L; Mezzadri, CM; Tubaro, E2
Anderloni, A; Bianchi Porro, G; Lazzaroni, M1
Chiloiro, M; Montanaro, S; Riezzo, G1
Biasi, G; Marcolongo, R1
Cavestro, GM; Coppelli, G; Coruzzi, G; Lo Giudice, P; Okolicsanyi, L; Pisano, C; Spaggiari, S; Tepperman, BL1
Belogi, L; Bettelli, E; Mezzadri, CM; Tubaro, E1
Coruzzi, G; Grandi, D; Guaita, E; Lazzaretti, M; Morini, G1
Huang, Y; Jin, Y; Li, J; Li, YH; Lu, XW1
Alexandova, A; Georgieva, A; Kesiova, M; Kirkova, M; Todorov, S; Tsvetanova, E1
Alexandrova, A; Kesiova, M; Kirkova, M; Konstantinova, S; Petrov, L; Todorov, S; Tsvetanova, E1
Alexandova, A; Kesiova, M; Kirkova, M; Todorov, S1
Bharathi, DV; Chatki, P; Hotha, KK; Kumar, SS; Mullangi, R; Ravindranath, LK; Reddy, YN; Veera, KN1
Dasari, VB; Hotha, KK; Korlakunta, JN; Lakshmanarao, RK; Mullangi, R; Shaik, AN; Shivva, V; Syed, M1
Li, X; Liu, D; Rong, Z; Xiang, D; Xu, Y; Zhang, C1
Adler, D; Andren, O; Biskup, S; Boehm, D; Braun, M; Bubendorf, L; Kirfel, J; Kristiansen, G; Menon, R; Offermann, A; Perner, S; Queisser, A; Rüenauver, K; Ruiz, C; Svensson, M; Vogel, W; Wernert, N; Zellweger, T1
Iida, S; Kikuchi, Y; Nakatsubo, T; Nishitani, S; Ohkuma, Y; Tanaka, A; Yamada, K1
Dahiya, P; Dwivedi, N; Maji, S; Nagulapalli, M; Thakur, JK1

Reviews

1 review(s) available for pyrroles and st 679

ArticleYear
[NSAID-induced gastrointestinal diseases: recent data on pathogenesis and prevention].
    Recenti progressi in medicina, 1999, Volume: 90, Issue:2

    Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cytoprotection; Duodenal Ulcer; Female; Gastrointestinal Diseases; Glycine; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Intestinal Diseases; Male; Middle Aged; Misoprostol; Pyrroles; Risk Factors; Stomach Ulcer; Sucralfate; Ulcer

1999

Trials

15 trial(s) available for pyrroles and st 679

ArticleYear
[A bioequivalence study of tablet and powder formulations of the nonsteroidal anti-inflammatory drug 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Glycine; Humans; Male; Powders; Pyrroles; Tablets; Therapeutic Equivalency; Time Factors; Tolmetin

1993
[A clinical study to determine the optimal dosage of ST-679 in the treatment of rheumatic diseases].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Dose-Response Relationship, Drug; Drug Tolerance; Female; Glycine; Humans; Male; Middle Aged; Pyrroles; Rheumatic Diseases

1993
[An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Glycine; Humans; Italy; Male; Middle Aged; Osteoarthritis; Pyrroles; Time Factors; Tolmetin

1993
[A bioequivalence study in man of tablet and capsule formulations of the nonsteroidal anti-inflammatory compound 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Female; Glycine; Humans; Male; Pyrroles; Tablets; Therapeutic Equivalency; Time Factors; Tolmetin

1993
[The drug treatment of postoperative pain].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Acetaminophen; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Female; Glycine; Humans; Italy; Male; Middle Aged; Minor Surgical Procedures; Pain Measurement; Pain, Postoperative; Pyrroles

1993
[The treatment of postoperative pain in obstetrical-gynecologic surgery. A comparative study between ST-679 and paracetamol].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Female; Genital Diseases, Female; Glycine; Humans; Middle Aged; Pain Measurement; Pain, Postoperative; Pregnancy; Pregnancy Complications; Pyrroles

1993
[An evaluation of the analgesic activity and tolerance of ST-679 in patients with pain following orthopedic and traumatological interventions].
    La Clinica terapeutica, 1993, Volume: 142, Issue:1 Pt 2

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Female; Glycine; Humans; Male; Middle Aged; Orthopedics; Pain Measurement; Pain, Postoperative; Pyrroles; Wounds and Injuries

1993
[Clinical trial comparing a new NSAID with 2 different dosages and diclofenac in patients with arthralgia in acute phase].
    La Clinica terapeutica, 1995, Volume: 146, Issue:10

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Drug Administration Schedule; Glycine; Humans; Male; Pyrroles

1995
[A clinical study on the anti-inflammatory activity and gastrointestinal tolerability of amtolmetin guacyl, a new NSAID, compared with diclofenac in aged patients with osteoarticular diseases].
    La Clinica terapeutica, 1997, Volume: 148, Issue:11

    Topics: Administration, Oral; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Data Interpretation, Statistical; Diclofenac; Drug Tolerance; Female; Gastric Mucosa; Gastroscopy; Glycine; Humans; Intestinal Mucosa; Middle Aged; Monitoring, Physiologic; Osteoarthritis; Pyrroles

1997
[Male urogenital amicrobial phlogosis: effects of the treatment with amtolmetin guacyl on some sperm parameters].
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 1999, Volume: 71, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Epididymitis; Glycine; Humans; Infertility, Male; Male; Prostatitis; Pyrroles; Seminal Vesicles; Sperm Count; Sperm Motility; Spermatozoa

1999
The effects on gastroduodenal mucosa of a new nonsteroidal anti-inflammatory drug, amtolmetin-guacyl, versus piroxicam in healthy volunteers: a short-term, double-blind, endoscopically controlled study.
    European journal of gastroenterology & hepatology, 2001, Volume: 13, Issue:7

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Duodenum; Endoscopy; Female; Gastric Mucosa; Glycine; Humans; Intestinal Mucosa; Male; Piroxicam; Pyrroles; Stomach

2001
Protective effect of amtolmetin guacyl versus placebo diclofenac and misoprostol in healthy volunteers evaluated as gastric electrical activity in alcohol-induced stomach damage.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cross-Over Studies; Diclofenac; Double-Blind Method; Electrophysiology; Ethanol; Gastric Emptying; Gastric Mucosa; Glycine; Humans; Misoprostol; Pyrroles; Stomach

2001
[Efficacy and safety of amtolmetin guacyl in the treatment of acute osteoarthritis].
    Minerva medica, 2001, Volume: 92, Issue:5

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Follow-Up Studies; Glycine; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Pyrroles; Time Factors

2001
Morphological features of rat gastric mucosa after acute and chronic treatment with amtolmetin guacyl: comparison with non-selective and COX-2-selective NSAIDs.
    Digestion, 2003, Volume: 68, Issue:2-3

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Gastric Mucosa; Glycine; Male; Microscopy, Electron; Pyrroles; Rats; Rats, Wistar

2003
Validation and clinical application of an LC-ESI-MS/MS method for simultaneous determination of tolmetin and MED5, the metabolites of amtolmetin guacil in human plasma.
    Biomedical chromatography : BMC, 2010, Volume: 24, Issue:10

    Topics: Chromatography, Liquid; Drug Stability; Glycine; Humans; Linear Models; Male; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tolmetin

2010

Other Studies

20 other study(ies) available for pyrroles and st 679

ArticleYear
Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin.
    Drugs under experimental and clinical research, 1992, Volume: 18, Issue:11-12

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Glycine; Lethal Dose 50; Male; Peptic Ulcer; Prodrugs; Pyrroles; Rats; Rats, Wistar; Tolmetin

1992
High-performance liquid chromatographic evaluation of Med 15 and its metabolites Med 5 and tolmetin in rat plasma.
    Journal of chromatography, 1991, Aug-16, Volume: 553, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Gas; Chromatography, High Pressure Liquid; Glycine; Male; Mass Spectrometry; Pyrroles; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Tolmetin

1991
Profile of activity of a new anti-inflammatory agent, ST 679 (MED 15).
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Concanavalin A; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Glycine; Inflammation; Nystatin; Pyrroles; Rats; Rats, Inbred Strains

1990
Studies on the gastric tolerability of the new non-steroidal anti-inflammatory drug amtolmetin guacyl.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Acid; Gastric Mucosa; Glycine; Male; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer

1995
Gastrosparing effect of new antiinflammatory drug amtolmetin guacyl in the rat: involvement of nitric oxide.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Gastric Mucosa; Glycine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Wistar; Tolmetin

1999
Gastric effects of the novel non-steroidal anti-inflammatory drug amtolmetin guacyl.
    Nutrition (Burbank, Los Angeles County, Calif.), 1999, Volume: 15, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycine; Humans; Nitric Oxide; Pyrroles; Stomach Diseases

1999
The mechanism of action of amtolmetin guacyl, a new gastroprotective nonsteroidal anti-inflammatory drug.
    European journal of pharmacology, 2000, Jan-10, Volume: 387, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Stability; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug

2000
Nitric oxide and non steroidal antiinflammatory drugs (NSAID)-related gastroduodenal damage.
    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2001, Volume: 56, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gastric Mucosa; Glycine; Humans; Nitric Oxide; Peptic Ulcer; Pyrroles

2001
Anti-inflammatory and antiplatelet effects of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
    Arzneimittel-Forschung, 2001, Volume: 51, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Body Weight; Bone Density; Carrageenan; Dose-Response Relationship, Drug; Exudates and Transudates; Glycine; In Vitro Techniques; Indomethacin; Male; Piroxicam; Platelet Aggregation; Platelet Aggregation Inhibitors; Pleurisy; Pyrroles; Rats; Thromboxane B2

2001
Gastroprotective effects of amtolmetin guacyl: a new non-steroidal anti-inflammatory drug that activates inducible gastric nitric oxide synthase.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Gastric Mucosa; Glycine; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pyrroles; Rats; Rats, Wistar; Tolmetin

2002
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dose-Response Relationship, Drug; Glycine; Guinea Pigs; Ileitis; Ileum; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pyrroles; Rats; Rats, Wistar; Sulfasalazine; Ulcer

2003
Gastroprotective effect and mechanism of amtolmetin guacyl in mice.
    World journal of gastroenterology, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressants; Ethanol; Female; Gastric Mucosa; Gastritis; Glycine; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Microscopy, Electron, Transmission; Microvilli; Nitric Oxide; Nitric Oxide Synthase; Pyrroles; Superoxide Dismutase

2004
Potential antioxidant activity of celecoxib and amtolmetin guacyl: in vitro studies.
    Autonomic & autacoid pharmacology, 2007, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Celecoxib; Deoxyribose; Free Radicals; Gastric Mucosa; Glycine; Intestinal Mucosa; Liver; Male; Nitroblue Tetrazolium; Oxidation-Reduction; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfonamides

2007
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems in different models of gastrointestinal injury.
    Autonomic & autacoid pharmacology, 2007, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastrointestinal Diseases; Glycine; Indomethacin; Intestinal Mucosa; Lipid Peroxidation; Liver; Male; Pyrroles; Rats; Rats, Wistar

2007
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs.
    Autonomic & autacoid pharmacology, 2007, Volume: 27, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catalase; Celecoxib; Colon; Cyclooxygenase 2 Inhibitors; Diclofenac; Gastric Mucosa; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glycine; Lipid Peroxidation; Liver; Male; Oxyphenonium; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfhydryl Compounds; Sulfonamides; Thiobarbituric Acid Reactive Substances; Tolmetin

2007
Species difference in the in vitro and in vivo metabolism of amtolmetin guacil.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:11

    Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chromatography, High Pressure Liquid; Cross-Over Studies; Glycine; Humans; In Vitro Techniques; Indicators and Reagents; Male; Microsomes, Liver; Plasma; Prodrugs; Pyrroles; Rats; Rats, Wistar; Species Specificity; Young Adult

2010
Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability.
    Life sciences, 2013, Feb-27, Volume: 92, Issue:3

    Topics: Adenosine; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Diketopiperazines; Glycine; Heterocyclic Compounds, 4 or More Rings; Intestinal Absorption; Intestinal Mucosa; Leukotriene Antagonists; Male; Mice; Mice, Knockout; Propionates; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Tolmetin; Vasodilator Agents; Verapamil

2013
MED15, encoding a subunit of the mediator complex, is overexpressed at high frequency in castration-resistant prostate cancer.
    International journal of cancer, 2014, 07-01, Volume: 135, Issue:1

    Topics: Aged; Androgens; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glycine; Humans; In Situ Hybridization, Fluorescence; Male; Mediator Complex; Middle Aged; Prostatic Neoplasms, Castration-Resistant; Pyrroles; Receptors, Androgen; Signal Transduction

2014
Human mediator subunit MED15 promotes transcriptional activation.
    Drug discoveries & therapeutics, 2014, Volume: 8, Issue:5

    Topics: Cell Nucleus; Glycine; HeLa Cells; Humans; Imidazoles; Piperazines; Plasmids; Pyrroles; RNA, Small Interfering; Transcription Factor TFIIH; Transcription Factors, TFII; Transcriptional Activation

2014
Evolution of disorder in Mediator complex and its functional relevance.
    Nucleic acids research, 2016, Feb-29, Volume: 44, Issue:4

    Topics: Amino Acid Sequence; Carrier Proteins; Conserved Sequence; Eukaryota; Evolution, Molecular; Glycine; Mediator Complex; Protein Interaction Maps; Pyrroles; Transcription, Genetic

2016