pyrroles and nadp
pyrroles has been researched along with nadp in 43 studies
Research
Studies (43)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (46.51) | 18.7374 |
| 1990's | 3 (6.98) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 9 (20.93) | 24.3611 |
| 2020's | 2 (4.65) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ertel, JC; Isseroff, H | 1 |
| Downing, SJ; Phang, JM; Smith, RJ; Williams, JA; Yeh, GC | 1 |
| Beale, SI; Rhie, G | 1 |
| Phang, JM | 1 |
| Meister, A; Seddon, AP; Zhao, KY | 1 |
| Hagedorn, CH; Mick, SJ; Thach, RE | 1 |
| Hagedorn, CH; Phang, JM | 2 |
| Hagedorn, CH | 1 |
| Fisher, HF; Srinivasan, R | 1 |
| Folsom, MD; Hodgson, E | 1 |
| Mattocks, AR; White, IN | 1 |
| Gray, CH; Nicholson, DC; Tipton, G | 1 |
| Frydman, B; Frydman, RB; Tomaro, ML; Wanschelbaum, A | 1 |
| Hagedorn, CH; Phang, JM; Yeh, GC | 1 |
| Downing, SJ; Hagedorn, CH; Phang, JM; Smith, RJ; Williams, JA; Yeh, GC | 1 |
| Bolt, E; Warren, MJ; Woodcock, SC | 1 |
| Downs, SM; Humpherson, PG; Leese, HJ | 1 |
| Coll, M; Cunningham, O; Darcy, K; Macedo-Ribeiro, S; Mantle, TJ; Párraga, A; Pereira, PJ; Pérez-Luque, R | 1 |
| Fahnestock, S; Jordan, DB; Liao, DI; Thompson, JE; Valent, B | 1 |
| Page, AM; Raitt, CE; Ryberg, M; Terry, MJ | 1 |
| Brandes, RP; Vecchione, C | 1 |
| ELLIS, RJ | 1 |
| ALBERTS, AW; MAJERUS, PW; VAGELOS, PR | 1 |
| HATTORI, M; KOUTRAS, GA; SCHNEIDER, AS; VALENTINE, WN | 1 |
| BLACK, S; COLMAN, RF | 1 |
| JELLINCK, PH; LAZIER, C | 1 |
| Gregus, Z; Németi, B | 1 |
| Brosnan, ME; Haslett, MR; Pink, D; Walters, B | 1 |
| Baer, BR; Henne, KR; Rettie, AE | 1 |
| Brown, S; de Crécy-Lagard, V; Iwata-Reuyl, D; Lee, B; Reddy, RR; Schimmel, P; Swairjo, MA; Van Lanen, SG | 1 |
| Chu, FM; Gong, AS; Guo, ZR; Sun, YM; Xu, HY; Zhang, P; Zhong, DF | 1 |
| Hirooka, Y; Kishi, T; Konno, S; Sunagawa, K | 1 |
| Hu, Z; Li, S; Liao, M; Ma, H; Wang, Q; Wang, Y; Wu, C; Yang, B; Yuan, Y; Zheng, Z | 1 |
| Ferrance, JP; Landers, JP; Weber, SG; Wu, J | 1 |
| Kohno, M; Mokudai, T; Niwano, Y; Sato, E | 1 |
| Christopher, LJ; Hong, H; Humphreys, WG; Iyer, RA; Ma, L; Su, H; Yao, M | 1 |
| Kuramoto, T; Mitsukura, K; Nagasawa, T; Shinoda, S; Suzuki, M; Yoshida, T | 1 |
| Hanefeld, U; Hollmann, F; Moeller, K; Nguyen, GS | 1 |
| Abe, K; Alzoubi, A; Fagan, KA; McMurtry, IF; O'Neill, KD; Oka, M; Rocic, P; Toba, M | 1 |
| Chen, Y; Guo, X; Li, Q; Li, W; Peng, Y; Zhao, G; Zheng, J | 1 |
| Avila, CC; Damasceno, FS; Elias, MC; Mantilla, BS; Marchese, L; Olavarria, K; Silber, AM; Souza, ROO | 1 |
| Forlani, G; Nocek, B; Ruszkowski, M | 1 |
Reviews
1 review(s) available for pyrroles and nadp
| Article | Year |
|---|---|
The regulatory functions of proline and pyrroline-5-carboxylic acid.
Topics: Amino Acids; Animals; Biological Transport; Cell Communication; Cell Cycle; Charcoal; Glutamates; Glutamic Acid; Humans; Mitosis; NADP; Neoplasms; Ornithine; Oxidation-Reduction; Phosphoribosyl Pyrophosphate; Proline; Protein Biosynthesis; Purine Nucleotides; Pyrroles; Structure-Activity Relationship | 1985 |
Other Studies
42 other study(ies) available for pyrroles and nadp
| Article | Year |
|---|---|
Proline in fascioliasis: III. Activities of pyrroline-5-carboxylic acid reductase and pyrroline-5-carboxylic acid dehydrogenase in Fasciola.
Topics: Animals; Carboxylic Acids; Fasciola hepatica; Hydrogen-Ion Concentration; Liver; NAD; NADP; Oxidoreductases; Oxidoreductases Acting on CH-NH Group Donors; Proline; Pyrroles; Rabbits; Rats | 1976 |
Stimulation of the hexose-monophosphate pentose pathway by delta 1-pyrroline-5-carboxylic acid in human fibroblasts.
Topics: Cells, Cultured; Fibroblasts; Glucose; Hexosephosphates; Humans; NADP; Oxidation-Reduction; Pentoses; Proline; Pyrroles; Pyrroline Carboxylate Reductases | 1979 |
Biosynthesis of phycobilins. Ferredoxin-supported nadph-independent heme oxygenase and phycobilin-forming activities from Cyanidium caldarium.
Topics: Cell Fractionation; Ferredoxins; Heme; Heme Oxygenase (Decyclizing); Kinetics; Molecular Structure; NADP; Oxidation-Reduction; Phycobilins; Phycocyanin; Pyrroles; Rhodophyta; Tetrapyrroles | 1992 |
Activation of glutamate by gamma-glutamate kinase: formation of gamma-cis-cycloglutamyl phosphate, an analog of gamma-glutamyl phosphate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aldehyde Oxidoreductases; Chromatography, High Pressure Liquid; Drug Stability; Escherichia coli; Glutamate-5-Semialdehyde Dehydrogenase; Glutamates; Glutamic Acid; Hydroxamic Acids; Kinetics; Molecular Conformation; NADP; Organophosphorus Compounds; Phosphates; Phosphotransferases; Phosphotransferases (Carboxyl Group Acceptor); Pyrroles; Pyrrolidonecarboxylic Acid | 1989 |
Selective inhibition of proteins synthesized from different mRNA species in reticulocyte lysates containing L-pyrroline-5-carboxylic acid.
Topics: Animals; Encephalomyocarditis virus; Globins; Glutathione; Medicago sativa; Mosaic Viruses; NAD; NADP; Protein Biosynthesis; Pyrroles; Rabbits; Rats; Reticulocytes; RNA, Messenger; RNA, Viral | 1988 |
Catalytic transfer of hydride ions from NADPH to oxygen by the interconversions of proline and delta 1-pyrroline-5-carboxylate.
Topics: Adenosine Triphosphate; Animals; Humans; Mitochondria, Liver; NADP; Oxidation-Reduction; Oxygen; Proline; Pyrroles; Rats | 1986 |
Demonstration of a NADPH-linked delta 1-pyrroline-5-carboxylate-proline shuttle in a cell-free rat liver system.
Topics: Animals; Cell-Free System; Cold Temperature; Mitochondria, Liver; NADP; Oxidation-Reduction; Pentose Phosphate Pathway; Proline; Pyrroles; Pyrroline Carboxylate Reductases; Rats; Solubility | 1986 |
Reversible reduction of an alpha-imino acid to an alpha-amino acid catalyzed by glutamate dehydrogenase: effect of ionizable functional groups.
Topics: Animals; Cattle; Glutamate Dehydrogenase; Kinetics; Liver; Mathematics; NADP; Oxidation-Reduction; Proline; Pyrroles | 1985 |
Biochemical characteristics of insect microsomes: NADPH oxidation by intact microsomes from the housefly, Musca domestica.
Topics: Animals; Carbon Monoxide; Chloromercuribenzoates; Copper; Cyanides; Cytochromes; Depression, Chemical; Ethylmaleimide; Female; Houseflies; Iodoacetates; Kinetics; Male; Microsomes; NAD; NADP; Oxidoreductases; Proadifen; Pyridines; Pyrroles; Stimulation, Chemical; Sulfhydryl Compounds; Zinc | 1970 |
The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.
Topics: Alkaloids; Animals; Calcium; Carbon Monoxide; DDT; Diet; Kinetics; Lung; Magnesium; Manganese; Microsomes; Microsomes, Liver; Models, Biological; NADP; Niacinamide; Oxides; Oxygen; Phenobarbital; Proadifen; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1971 |
Degradation of haem compounds to bile pigments.
Topics: Aldehydes; Animals; Bile Pigments; Chemical Phenomena; Chemistry; Dicarboxylic Acids; Dogs; Heme; Hemoglobins; Isomerism; Kidney; Liver; Mice; Mononuclear Phagocyte System; NADP; Oxidation-Reduction; Oxidoreductases; Oxygenases; Pyrroles | 1972 |
The enzymatic oxidation of porphobilinogen.
Topics: Ammonium Sulfate; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Thin Layer; Cobalt; Freezing; Ketones; Kinetics; Microsomes, Liver; NADP; Nickel; Oxygenases; Plants; Polarography; Porphobilinogen; Porphyrins; Pyrroles; Rats; Spectrophotometry; Sulfites | 1972 |
Transfer of reducing equivalents into mitochondria by the interconversions of proline and delta 1-pyrroline-5-carboxylate.
Topics: Animals; Catalysis; Cell-Free System; Cytosol; Glucose; Glucosephosphate Dehydrogenase; Humans; In Vitro Techniques; Male; Mitochondria, Liver; NADP; Oxidation-Reduction; Proline; Pyrroles; Pyrroline Carboxylate Reductases; Rats; Rats, Inbred Strains | 1983 |
The intercellular proline cycle.
Topics: Animals; Erythrocytes; Humans; Liver; Mice; Mitochondria, Liver; NADP; Proline; Proline Oxidase; Pyrroles; Pyrroline Carboxylate Reductases | 1981 |
Stimulation of the hexosemonophosphate-pentose pathway by pyrroline-5-carboxylate in cultured cells.
Topics: Animals; Cell Line; Cells, Cultured; Citric Acid Cycle; Cricetinae; Female; Fibroblasts; Glucose; Hexosephosphates; Humans; Kidney; NADP; Ovary; Oxidation-Reduction; Pentoses; Proline; Pyrroles; Pyrroline Carboxylate Reductases; Rabbits | 1982 |
5-Aminolaevulinic acid synthase and uroporphyrinogen methylase: two key control enzymes of tetrapyrrole biosynthesis and modification.
Topics: Amino Acid Sequence; Binding Sites; Escherichia coli; Methyltransferases; Molecular Sequence Data; NADP; Pyrroles; Rhodobacter sphaeroides; Sequence Homology; Tetrapyrroles; Transaminases | 1994 |
Meiotic induction in cumulus cell-enclosed mouse oocytes: involvement of the pentose phosphate pathway.
Topics: Animals; Deoxyglucose; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Glucosephosphate Dehydrogenase; Meiosis; Methylene Blue; Mice; Mice, Inbred C57BL; NADP; NADPH Oxidases; Oocytes; Ovarian Follicle; Oxidation-Reduction; Pentose Phosphate Pathway; Phenazines; Phosphogluconate Dehydrogenase; Pyrroles | 1998 |
Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.
Topics: Amino Acid Sequence; Bilirubin; Binding Sites; Crystallography, X-Ray; Fetus; Flavin Mononucleotide; Humans; Models, Molecular; Molecular Sequence Data; NADP; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Structure, Secondary; Pyrroles; Sequence Alignment; Stereoisomerism; Substrate Specificity; Tetrapyrroles | 2001 |
A structural account of substrate and inhibitor specificity differences between two naphthol reductases.
Topics: Antifungal Agents; Binding, Competitive; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Fungal Proteins; NADP; Naphthols; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrroles; Quinolines; Substrate Specificity | 2001 |
Altered etioplast development in phytochrome chromophore-deficient mutants.
Topics: Arabidopsis; Darkness; Heme; Hypocotyl; Microscopy, Electron; Mutation; NADP; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phytochrome; Pisum sativum; Plants, Genetically Modified; Plastids; Protochlorophyllide; Pyrroles; Signal Transduction; Solanum lycopersicum; Tetrapyrroles | 2001 |
Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice.
Topics: Acridines; Animals; Aorta; Atorvastatin; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Fluoresceins; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADP; NADPH Oxidase 2; NADPH Oxidases; Organ Culture Techniques; Oxidative Stress; Protein Transport; Pyridines; Pyrroles; rac1 GTP-Binding Protein; Superoxides; Vasodilation | 2002 |
A RAPID ASSAY FOR SULPHITE REDUCTASE.
Topics: Biological Assay; Colorimetry; Culture Media; Cysteine; Escherichia coli; Ethylmaleimide; Glutathione; Metabolism; Methionine; NADP; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Pyrroles; Research; Sulfides; Sulfites; Sulfonic Acids; Thiosulfates | 1964 |
ACYL CARRIER PROTEIN. 3. AN ENOYL HYDRASE SPECIFIC FOR ACYL CARRIER PROTEIN THIOESTERS.
Topics: Acyl Carrier Protein; Bacterial Proteins; Enoyl-CoA Hydratase; Escherichia coli; Ethylmaleimide; Fatty Acids; Hydro-Lyases; Hydroxamic Acids; Hydroxybutyrates; NAD; NADP; Pyrroles; Research; Spectrophotometry; Sulfhydryl Compounds; Sulfonic Acids | 1965 |
STUDIES ON CHROMATED ERYTHROCYTES. MECHANISMS OF CHROMATE INHIBITION OF GLUTATHIONE REDUCTASE.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Chemical Phenomena; Chemistry; Chromates; Enzyme Inhibitors; Erythrocytes; Ethylmaleimide; Glucosephosphate Dehydrogenase Deficiency; Glucosephosphates; Glutathione; Glutathione Reductase; Leukocytes; NAD; NADP; Nucleosides; Pharmacology; Pyrroles; Research; Saccharomyces | 1965 |
ON THE ROLE OF FLAVIN ADENINE DINUCLEOTIDE AND THIOL GROUPS IN THE CATALYTIC MECHANISM OF YEAST GLUTATHIONE REDUCTASE.
Topics: Carbon Isotopes; Catalysis; Electrophoresis; Ethylmaleimide; Flavin-Adenine Dinucleotide; Glutathione Reductase; Mercaptoethanol; Molecular Weight; NADP; Pyrroles; Radiometry; Research; Spectrophotometry; Sulfhydryl Compounds; Sulfites; Ultracentrifugation; Urea | 1965 |
INHIBITION OF C-ESTRONE METABOLISM IN RAT LIVER MICROSOMES BY 2-HYDROXYESTROGENS AND RELATED COMPOUNDS.
Topics: Ascorbic Acid; Autoradiography; Benzoates; Biphenyl Compounds; Catalase; Chloromercuribenzoates; Chromatography; Copper; Cyanides; Diethylstilbestrol; Edetic Acid; Estradiol Congeners; Estrogens; Estrone; Ethylmaleimide; Fluorides; Liver; Microsomes; Microsomes, Liver; NADP; Pharmacology; Phenanthrolines; Pyrroles; Rats; Research | 1965 |
Glutathione-dependent reduction of arsenate in human erythrocytes--a process independent of purine nucleoside phosphorylase.
Topics: Arsenates; Arsenite Transporting ATPases; Blood Glucose; Dithiothreitol; Erythrocytes; Ferricyanides; Glucose Oxidase; Glutathione; Humans; In Vitro Techniques; Inosine; Ion Pumps; Multienzyme Complexes; NADP; Oxidation-Reduction; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyruvic Acid; Spectrophotometry, Atomic | 2004 |
Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver.
Topics: Animals; Glutamic Acid; Liver; Male; Mitochondria; NADP; Ornithine; Ornithine-Oxo-Acid Transaminase; Proline; Proline Oxidase; Pyrroles; Rats; Rats, Sprague-Dawley; Rotenone; Subcellular Fractions; Ultracentrifugation | 2004 |
Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
Topics: Acetylcysteine; Aldehydes; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 Enzyme System; Glutathione; Humans; Liver; Lung; Lysine; NADP; Pyrroles; Rabbits; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.
Topics: Bacillus subtilis; Catalysis; Computational Biology; Crystallization; Crystallography, X-Ray; GTP Cyclohydrolase; Guanine; Models, Chemical; Models, Molecular; NADP; Nucleoside Q; Oxidoreductases; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Pyrimidinones; Pyrroles; RNA Processing, Post-Transcriptional; RNA, Transfer; X-Ray Diffraction | 2005 |
Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes.
Topics: Animals; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Ketoconazole; Male; Microsomes, Liver; NADP; Pyrroles; Rats; Rats, Wistar; Sulfides | 2006 |
Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atorvastatin; Baroreflex; Heptanoic Acids; Hypertension; Injections, Intraventricular; Male; Medulla Oblongata; NADP; Oxidative Stress; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Superoxide Dismutase; Sympathetic Nervous System | 2010 |
Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2-one-induced hepatotoxicity in Wistar rats.
Topics: Amino Acids; Animals; Apoptosis; Blood Proteins; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Female; Histocytochemistry; In Situ Nick-End Labeling; Liver; Mass Spectrometry; Mesylates; NADP; Proteome; Proteomics; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species | 2010 |
Integration of a precolumn fluorogenic reaction, separation, and detection of reduced glutathione.
Topics: Fluorescent Dyes; Glutathione; Hydrogen-Ion Concentration; Kinetics; Microfluidic Analytical Techniques; NADP; Naphthalenes; Oxidation-Reduction; Pyrroles; Spectrometry, Fluorescence; Temperature | 2010 |
Kinetic analysis of reactive oxygen species generated by the in vitro reconstituted NADPH oxidase and xanthine oxidase systems.
Topics: Cyclic N-Oxides; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; Kinetics; NADP; NADPH Oxidases; Pyrroles; Reactive Oxygen Species; Spin Trapping; Superoxides; Xanthine Oxidase | 2011 |
In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
Topics: Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; ErbB Receptors; Glucuronosyltransferase; Hepatocytes; Humans; Microsomes, Liver; NADP; Piperidines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Triazines; Uridine Diphosphate Glucuronic Acid | 2011 |
Purification and characterization of a novel (R)-imine reductase from Streptomyces sp. GF3587.
Topics: Chromatography, Gel; Dimerization; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Imines; Kinetics; Methylation; Molecular Weight; NADP; Oxidoreductases; p-Chloromercuribenzoic Acid; Protein Subunits; Pyrroles; Pyrrolidines; Streptomyces; Substrate Specificity; Sulfhydryl Reagents | 2011 |
Expression and characterization of the nitrile reductase queF from E. coli.
Topics: Bacillus subtilis; Base Sequence; Catalytic Domain; Enzyme Stability; Escherichia coli K12; Escherichia coli Proteins; Genes, Bacterial; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; NADP; Nuclear Magnetic Resonance, Biomolecular; Nucleoside Q; Oxidoreductases; Protein Conformation; Pyrimidinones; Pyrroles; Recombinant Fusion Proteins; Substrate Specificity; Temperature | 2013 |
Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Blood Pressure; Dehydroepiandrosterone; Fibrosis; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; NADP; NFATC Transcription Factors; Oxidative Stress; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; STAT3 Transcription Factor; Ventricular Dysfunction | 2013 |
Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Assays; Humans; Ketoconazole; Male; Microsomes, Liver; NADP; Piperidines; Pyrimidines; Pyrroles | 2019 |
Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools.
Topics: Cytosol; Electron Transport; Glutamic Acid; Mitochondria; NADP; Oxidation-Reduction; Proline; Pyrroles; Pyrroline Carboxylate Reductases; Trypanosoma cruzi | 2020 |
Peculiar substrate specificity of δ
Topics: Catalysis; Electrons; Kinetics; NAD; NADP; Oxidoreductases; Pyrroles; Substrate Specificity; Zymomonas | 2021 |