pyrroles and n6022
pyrroles has been researched along with n6022 in 14 studies
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (92.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Blonder, JP; Chun, L; Colagiovanni, DB; Green, LS; Mutka, SC; Qiu, J; Richards, JP; Rosenthal, GJ; Stout, AM; Strong, SA; Sun, X; Wasley, JW | 1 |
| Blonder, JP; Colagiovanni, DB; Green, LS; Mutka, SC; Qiu, J; Richards, JP; Rosenthal, GJ; Stout, AM; Strong, SA; Sun, X; Wasley, JW | 2 |
| Colagiovanni, DB; Drolet, DW; Langlois-Forget, E; Looker, D; Piché, MP; Rosenthal, GJ | 1 |
| Chun, LE; Green, LS; Patton, AK; Richards, JP; Rosenthal, GJ; Sun, X | 1 |
| Blonder, JP; Boyanapalli, R; Delany, C; Green, LH; Look, K; Looker, D; Mehra, NK; Mutka, SC; Qiu, J; Richards, JP; Rosenthal, GJ; Scoggin, C; Sun, X; Suniga, M | 1 |
| Bodas, M; Brucia, K; Silverberg, D; Vij, N; Walworth, K | 1 |
| Baker, JE; Barnett, SD; Buxton, ILO; Smith, CR; Ulrich, CC | 1 |
| Katial, RK; Kraft, M; Lugogo, NL; Que, LG; Rodman, DM; Shoemaker, SA; Tighe, RM; Troha, JM; Yang, Z | 1 |
| Bochkov, YA; Foster, MW; Que, LG; Voelker, DR; Yang, Z | 1 |
| Bedja, D; Biswal, S; Casin, KM; Chan, A; Fallica, J; Kohr, MJ; Mackowski, N; St Paul, A; Veenema, RJ; Zhu, G | 1 |
| Berčíková, L; Činčalová, L; Jedelská, T; Kraiczová, VŠ; Luhová, L; Petřivalský, M | 1 |
| Dhammu, TS; Khan, M; Kumar, P; Qiao, F; Singh, AK; Singh, I | 1 |
| Feng, W; Islam, SMT; Khan, M; Kumar, P; Qiao, F; Singh, AK; Singh, I; Won, JS | 1 |
Trials
1 trial(s) available for pyrroles and n6022
| Article | Year |
|---|---|
Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.
Topics: Administration, Intravenous; Adult; Aldehyde Oxidoreductases; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Placebos; Proof of Concept Study; Pyrroles; S-Nitrosoglutathione; Treatment Outcome; Young Adult | 2018 |
Other Studies
13 other study(ies) available for pyrroles and n6022
| Article | Year |
|---|---|
Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement.
Topics: Aldehyde Oxidoreductases; Benzamides; Enzyme Activation; Enzyme Inhibitors; Inhibitory Concentration 50; Molecular Structure; Propionates; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2011 |
Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities.
Topics: Aldehyde Oxidoreductases; Animals; Asthma; Benzamides; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Imidazoles; Lung; Mice; Molecular Structure; Molecular Targeted Therapy; No-Observed-Adverse-Effect Level; Pyrroles; Receptors, Opioid, delta; S-Nitrosoglutathione; Structure-Activity Relationship | 2011 |
A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma.
Topics: Alanine Transaminase; Aldehyde Oxidoreductases; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Asthma; Benzamides; Bile; Cell Line, Tumor; Cell Survival; Drug Evaluation, Preclinical; Enzyme Inhibitors; Feces; Female; Glutathione; Liver; Lung; Male; Pyrroles; Rats; Rats, Sprague-Dawley | 2012 |
Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase.
Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Benzamides; Binding, Competitive; Catalytic Domain; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Models, Biological; Models, Molecular; Pyrroles; Recombinant Proteins; S-Nitrosoglutathione | 2012 |
Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification.
Topics: Acute Disease; Aldehyde Oxidoreductases; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Enzyme Inhibitors; Humans; Male; Mice; Ovalbumin; Pyrroles; S-Nitrosoglutathione; S-Nitrosothiols; Structure-Activity Relationship | 2012 |
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation.
Topics: Aldehyde Oxidoreductases; Animals; Asthma; Benzamides; Bronchoconstriction; Female; Inflammation; Mice; Mice, Inbred BALB C; Pyrroles | 2014 |
Augmentation of S-Nitrosoglutathione Controls Cigarette Smoke-Induced Inflammatory-Oxidative Stress and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis by Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function.
Topics: Animals; Autophagy; Benzamides; Cell Line; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Mice; Oxidative Stress; Protein Aggregates; Pulmonary Emphysema; Pyrroles; S-Nitrosoglutathione; Smoke; Tobacco Products | 2017 |
S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor.
Topics: Actins; Aldehyde Oxidoreductases; Benzamides; Cyclic GMP; Female; Guanylate Cyclase; Humans; Muscle, Smooth; Myometrium; Myosins; Nitric Oxide; Nitrosation; Obstetric Labor, Premature; Pregnancy; Pyrroles; S-Nitrosoglutathione; Uterine Contraction | 2018 |
Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells.
Topics: Aldehyde Oxidoreductases; Benzamides; Bronchi; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Humans; Inflammation; Nitric Oxide Synthase Type II; Picornaviridae Infections; Pyrroles; Rhinovirus; Virus Replication | 2019 |
S-Nitrosoglutathione Reductase Is Essential for Protecting the Female Heart From Ischemia-Reperfusion Injury.
Topics: Alcohol Dehydrogenase; Animals; Benzamides; Cardiotonic Agents; Enzyme Inhibitors; Female; Heart; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Pyrroles; Sex Factors | 2018 |
Tomato Root Growth Inhibition by Salinity and Cadmium Is Mediated By S-Nitrosative Modifications of ROS Metabolic Enzymes Controlled by S-Nitrosoglutathione Reductase.
Topics: Aldehyde Oxidoreductases; Ascorbate Peroxidases; Benzamides; Cadmium; Gene Expression Regulation, Plant; Hydrogen Peroxide; NADPH Oxidases; Nitric Oxide; Nitrosation; Oxidative Stress; Plant Proteins; Plant Roots; Pyrroles; Reactive Nitrogen Species; Reactive Oxygen Species; S-Nitrosoglutathione; S-Nitrosothiols; Sodium Chloride; Solanum; Solanum lycopersicum; Stress, Physiological | 2019 |
S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke.
Topics: Alcohol Dehydrogenase; Animals; Behavior, Animal; Benzamides; Brain; Brain Edema; Disease Models, Animal; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; S-Nitrosoglutathione | 2019 |
Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.
Topics: Aging; Alcohol Dehydrogenase; Animals; Benzamides; Disease Models, Animal; Drug Delivery Systems; Male; Mice; Mice, Inbred C57BL; Pyrroles; Recovery of Function; Stroke | 2020 |