pyrroles has been researched along with morphine in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (26.56) | 18.7374 |
1990's | 17 (26.56) | 18.2507 |
2000's | 18 (28.13) | 29.6817 |
2010's | 8 (12.50) | 24.3611 |
2020's | 4 (6.25) | 2.80 |
Authors | Studies |
---|---|
Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL | 2 |
Brice, AG; Cornfeldt, M; Forster, AM; Forster, HV; Forster, MA; Hubbard, JW; Locke, KW; Lowry, TF; Pan, LG; Vanselous, CL | 1 |
Cowan, A; Wheeler-Aceto, H | 2 |
Cowan, A; Ianone, M; Porreca, F; Wheeler, H | 1 |
Bovill, JG; Bravo, LJ; Burm, AG; Mattie, H; Spierdijk, J | 1 |
Bullingham, RE; Gillies, GW; Kenny, GN; McArdle, CS | 1 |
Fragen, RJ; Kinzer, M; O'Hara, DA; Pemberton, D | 1 |
Dhasmana, KM; Dixit, KS; Gupta, ML; Jaju, BP | 1 |
Della Bella, D; Ferrari, V; Frigeni, C; Lualdi, P | 1 |
Babbini, M; Bartoletti, M; Gaiardi, M | 1 |
Cheney, D; Costa, E; Revuelta, A | 1 |
Frigerio, G | 1 |
Gardocki, JF; Muschek, LD; Pruss, TP; Taylor, RJ | 1 |
Forrest, WH | 2 |
Jasinski, DR; Johnson, RE; Kocher, TR | 1 |
Blanchard, JC; Carruette, A; Garret, C; Laduron, PM; Montier, F; Moussaoui, SM | 1 |
Carruette, A; Garret, C; Moussaoui, S | 1 |
Funada, M; Kamei, J; Kawashima, N; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takamori, K | 1 |
Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Narita, M; Suzuki, T | 1 |
Nagasaka, H; Yaksh, TL | 1 |
Baeyens, JM; Barrios, M; Robles, LI | 1 |
Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Poggioli, R | 1 |
Baeyens, JM; Barrios, M; Ocaña, M | 1 |
Grouhel, A; Wettstein, JG | 1 |
Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
Farouz-Grant, F; Portoghese, PS | 1 |
Chakrabarti, S; Law, PY; Loh, HH | 1 |
Kamei, J; Ohsawa, M | 1 |
Ahlner, J; Förstberg-Peterson, S; Kågedal, B; Kronstrand, R; Larson, G | 1 |
Alvaro, JD; Chen, YL; Duman, RS; Iredale, PA; Lee, Y; Terwilliger, R | 1 |
Bordi, F; Quartaroli, M | 1 |
Ceng, X; Huang, M; Lu, L | 1 |
Ceng, X; Liu, D; Lu, L; Ma, L | 1 |
Bettelini, L; Corsi, M; Fasdelli, N; Maraia, G; Quartaroli, M | 1 |
Mizuo, K; Narita, M; Shibasaki, M; Suzuki, T | 1 |
Bordi, F; Cavallini, P; Cavanni, P; Di Fabio, R; Donati, D; Faedo, S; Maffeis, M; Micheli, F; Sabbatini, FM; Tarzia, G; Tranquillini, ME | 1 |
Dewey, WL; Elzey, MJ; Javed, RR; Smith, FL | 1 |
Kato, H; Narita, M; Oe, K; Shibasaki, M; Suzuki, T; Yajima, Y; Yamazaki, M | 1 |
Cador, M; Koob, GF; Stinus, L; Zorrilla, EP | 1 |
Dewey, WL; Javed, RR; Smith, FL; Smith, PA | 1 |
Blackburn-Munro, G; Bomholt, SF; Erichsen, HK | 1 |
Aceto, MD; Breeden, S; Husbands, SM; Ko, MC; Lewis, JW; Neilan, CL; Traynor, JR; Woods, JH | 1 |
Fang, Q; Liu, Z; Lu, L; Wang, J | 1 |
Dewey, WL; Gabra, BH; Javed, RR; Smith, FL; Smith, PA | 1 |
Ahmadiani, A; Esmaeili-Mahani, S; Javan, M; Koibuchi, N; Maghsoudi, N; Motamedi, F; Shimokawa, N | 1 |
Divin, MF; Holden Ko, MC; Traynor, JR | 1 |
Negus, SS; Rice, KC | 1 |
Fujita-Hamabe, W; Nakamoto, K; Tokuyama, S | 1 |
Agnati, LF; Brené, S; de la Calle, A; Fuxe, K; Gago, B; Reina-Sánchez, MD; Rivera, A; Rodríguez-Pérez, LM; Suárez-Boomgaard, D | 1 |
Bhutada, PS; Mundhada, YR; Umathe, SN | 1 |
Almela, P; García-Carmona, JA; Hidalgo, J; Laorden, ML; Milanés, MV; Mora, L; Navarro-Zaragoza, J | 1 |
Korostyński, M; Kubik, J; Piechota, M; Przewłocki, R; Ziółkowska, B | 1 |
Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Takeda, K; Watanabe, C | 1 |
Laorden, ML; Lasheras, MC; Milanés, MV; Núñez, C | 1 |
Almela, P; Camejo, DM; García-Carmona, JA; Jiménez, A; Laorden, ML; Milanés, MV; Sevilla, F | 1 |
Almela, P; Laorden, ML; Martínez-Laorden, E; Milanés, MV; Navarro-Zaragoza, J | 1 |
Han, C; He, L; Lei, D; Li, S; Liu, L; Ma, T; Wen, S; Xie, S; Zhou, H | 1 |
Cong, X; Giorgetti, A; Sena, DM | 1 |
Almela, P; Cánovas, A; Gómez-Murcia, V; Laorden, ML; Martínez-Laorden, E; Milanés, MV; Navarro-Zaragoza, J; Teruel-Fernández, FJ | 1 |
Blumenthal, S; Bronson, RT; Kanayama, R; Ruebner, BH | 1 |
Bergstrom, DE; Blumenthal, SG; Hanson, FW; Ikeda, RM; Rasmussen, RD; Ruebner, BH; Stucker, T | 1 |
8 trial(s) available for pyrroles and morphine
Article | Year |
---|---|
The effects on ventilation of ketorolac in comparison with morphine.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Humans; Ketorolac; Male; Morphine; Pyrroles; Random Allocation; Respiration; Tolmetin | 1988 |
The morphine sparing effect of ketorolac tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery.
Topics: Abdomen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; Infusions, Parenteral; Ketorolac Tromethamine; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin; Tromethamine | 1987 |
Ketorolac tromethamine as compared with morphine sulfate for treatment of postoperative pain.
Topics: Adult; Aged; Drug Combinations; Female; Humans; Injections, Intramuscular; Ketorolac Tromethamine; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin; Tromethamine | 1987 |
[Viminol in the treatment of pain. Double-blind, controlled, multicentric trial].
Topics: Aminopyrine; Analgesics; Aspirin; Benzoates; Benzyl Compounds; Dextropropoxyphene; Drug Evaluation; Drug Tolerance; Ethanolamines; Female; Humans; Male; Morphine; Nausea; Pain; Pentazocine; Phenylbutazone; Pyrroles; Sleep Wake Disorders; Vertigo | 1974 |
Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain.
Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin | 1980 |
Abuse potential of zomepirac.
Topics: Blood Pressure; Drug Evaluation; Euphoria; Humans; Morphine; Pupil; Pyrroles; Substance-Related Disorders; Surveys and Questionnaires; Tolmetin | 1983 |
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain.
Topics: Administration, Oral; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injections, Intramuscular; Male; Morphine; Neoplasms; Pain, Postoperative; Pyrroles; Tolmetin | 1980 |
Oral zomepirac and intramuscular morphine in postoperative pain.
Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Injections, Intramuscular; Morphine; Pain, Postoperative; Pyrroles; Time Factors; Tolmetin | 1980 |
56 other study(ies) available for pyrroles and morphine
Article | Year |
---|---|
Clinical analgesic assay of oral zomepirac and intramuscular morphine.
Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morphine; Pain; Pain, Postoperative; Pyrroles; Research Design; Tolmetin | 1979 |
Cardiorespiratory effects of the novel opioid analgesic HP 736 in the anesthetized dog and conscious goat.
Topics: Analgesics, Opioid; Animals; Atropine; Carbon Dioxide; Dogs; Female; Goats; Hemodynamics; In Vitro Techniques; Indoles; Male; Mice; Morphine; Oxygen; Pyrroles; Rats; Rats, Inbred Strains; Respiration | 1992 |
Involvement of a peripheral component in the antinociceptive effects of opioids in a model of tonic pain.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1990 |
Standardization of the rat paw formalin test for the evaluation of analgesics.
Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reference Standards; Thiophenes | 1991 |
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats.
Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1989 |
Role of central dopaminergic receptors in manic response of cats to morphine.
Topics: Animals; Atropine; Bipolar Disorder; Cats; Central Nervous System; Chlorpromazine; Dopamine; Drug Antagonism; Female; Haloperidol; Histamine H1 Antagonists; Humans; Lysergic Acid Diethylamide; Male; Morphine; Phenoxybenzamine; Propranolol; Pyrroles; Receptors, Drug; Reserpine; Tetrabenazine | 1972 |
Agonistic and antagonistic properties of diastereoisomers in a new central analgesic.
Topics: Analgesics; Animals; Benzyl Compounds; Butylamines; Ethanolamines; Humans; Mice; Morphine; Nalorphine; Naloxone; Pyrroles; Stereoisomerism; Substance-Related Disorders | 1973 |
Some behavioral and EEG effects of a new analgesic agent (viminol) in comparison with morphine in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzyl Compounds; Butylamines; Conditioning, Operant; Dose-Response Relationship, Drug; Electroencephalography; Ethanolamines; Humans; Lethal Dose 50; Locomotion; Male; Meperidine; Meprobamate; Methadone; Morphine; Pyrroles; Rats; Substance-Related Disorders; Time Factors | 1973 |
Stereoisomers of viminol: catalepsy and brain monoamine turnover rate.
Topics: Analgesics; Animals; Benzyl Compounds; Biogenic Amines; Brain; Brain Chemistry; Butylamines; Catalepsy; Catecholamines; Cerebellum; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Ethanolamines; Humans; Kinetics; Male; Mice; Morphine; Motor Activity; Neurons; Norepinephrine; Pyrroles; Rats; Serotonin; Stereoisomerism; Structure-Activity Relationship; Telencephalon; Time Factors | 1973 |
Evaluation of the analgesic properties of zomepirac.
Topics: Analgesics; Animals; Cattle; Cyclooxygenase Inhibitors; Drug Interactions; Hindlimb; Humans; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Platelet Aggregation; Pyrroles; Reaction Time; Receptors, Opioid; Substance-Related Disorders; Tolmetin | 1980 |
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Electric Stimulation; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Morphine; Mucus; Nasal Mucosa; Pyrroles; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synapses; Thiophenes; Xylenes | 1993 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes | 1993 |
Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Cromakalim; Glyburide; Injections, Intraventricular; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Morphine; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord; Stimulation, Chemical | 1993 |
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Tetraethylammonium Compounds | 1994 |
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes | 1995 |
ATP-sensitive K+ channel openers inhibit morphine withdrawal.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Benzopyrans; Body Weight; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Morphine; Naloxone; Potassium Channels; Pyrroles; Substance Withdrawal Syndrome | 1994 |
K+ channel openers delay intestinal transit and have antidiarrheal activity.
Topics: Animals; Benzopyrans; Cromakalim; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guanidines; Male; Mice; Mice, Inbred Strains; Morphine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Cromakalim differentially enhances antinociception induced by agonists of alpha(2)adrenoceptors, gamma-aminobutyric acid(B), mu and kappa opioid receptors.
Topics: Animals; Baclofen; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain; Pyrroles; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 1996 |
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Chemical; Morphinans; Morphine; Muscle, Smooth; Pyrroles; Receptors, Opioid, delta; Stereoisomerism | 1997 |
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
Topics: Analgesics, Opioid; Antibody Specificity; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Indoles; Morphine; Neuroblastoma; Neurons; Phosphorylation; Precipitin Tests; Pyrroles; Receptors, Opioid, mu; Tumor Cells, Cultured | 1998 |
Modification of the expression of naloxone-precipitated withdrawal signs in morphine-dependent mice by diabetes: possible involvement of protein kinase C.
Topics: Animals; Behavior, Animal; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Frontal Lobe; Indoles; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Substance Withdrawal Syndrome | 1999 |
Codeine concentration in hair after oral administration is dependent on melanin content.
Topics: Chromatography, High Pressure Liquid; Codeine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Melanins; Morphine; Narcotics; Pyrroles; Substance Abuse Detection | 1999 |
Role of corticotropin-releasing factor receptor-1 in opiate withdrawal.
Topics: Animals; Behavior, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Protein Isoforms; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2000 |
Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hot Temperature; Indoles; Male; Morphine; Nerve Compression Syndromes; Neurons; Nociceptors; Pain Measurement; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reference Values; Sciatic Nerve; Synaptic Transmission; Touch; Ventral Thalamic Nuclei | 2000 |
Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Morphine; Neuropsychological Tests; Opioid-Related Disorders; Psychomotor Performance; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Secondary Prevention; Stress, Physiological | 2000 |
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence.
Topics: Animals; Cerebral Ventricles; Choice Behavior; Corticotropin-Releasing Hormone; Hormone Antagonists; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Naloxone; Peptide Fragments; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2000 |
GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
Topics: Animals; Behavior, Animal; Binding Sites; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Indoles; Ligation; Male; Mice; Morphine; Narcotics; Neuralgia; Pain; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Stress, Mechanical | 2001 |
Up-regulation of the G(q/11alpha) protein and protein kinase C during the development of sensitization to morphine-induced hyperlocomotion.
Topics: Animals; Disease Susceptibility; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Hyperkinesis; Indoles; Limbic System; Male; Mesencephalon; Mice; Morphine; Narcotics; Prosencephalon; Protein Isoforms; Protein Kinase C; Pyrroles; RGS Proteins; Up-Regulation | 2002 |
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Electrophysiology; Esters; Excitatory Amino Acid Antagonists; Indicators and Reagents; Morphine; Neurons; Nociceptors; Pyrroles; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Structure-Activity Relationship; Synaptic Transmission; Thalamus | 2003 |
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.
Topics: Analgesics; Animals; Brain; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoquinolines; Male; Maleimides; Mice; Morphine; Morphine Dependence; Pain; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrroles | 2003 |
Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Indoles; Ligation; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Neuralgia; Protein Kinase C; Pyrroles; Reward; Sciatic Neuropathy; Spinal Cord; Up-Regulation | 2004 |
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.
Topics: Acamprosate; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Avoidance Learning; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Implants; Fluoxetine; Lisuride; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome; Taurine | 2005 |
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice.
Topics: Analgesics, Opioid; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Tolerance; Hypothermia, Induced; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Maleimides; Mice; Morphine; Pain Measurement; Protein Kinase C; Pyrroles; Tail | 2004 |
Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Kainic Acid; Tetrahydroisoquinolines; Time Factors | 2004 |
Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
Topics: Analgesics; Animals; Binding, Competitive; Buprenorphine; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Pain; Pain Measurement; Pyrroles; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors; Tritium; Vas Deferens | 2004 |
Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Central Nervous System Agents; Cocaine; Conditioning, Operant; Extinction, Psychological; Heroin; Injections, Intraventricular; Learning; Male; Morphine; Nucleus Accumbens; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Reinforcement, Psychology; Septal Nuclei; Stress, Psychological | 2006 |
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Drug Implants; Drug Tolerance; Enzyme Inhibitors; Hot Temperature; Hypothermia; Indoles; Injections, Intraventricular; Isoquinolines; Male; Maleimides; Mice; Morphine; Pain; Protein Kinase C; Pyrroles; Reaction Time | 2006 |
Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.
Topics: Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression; GTP-Binding Proteins; Hyperalgesia; Immunoblotting; Indoles; Male; Morphine; Nifedipine; Polymerase Chain Reaction; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord | 2008 |
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
Topics: Animals; Binding, Competitive; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pyrroles; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2008 |
Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys.
Topics: Adrenergic Agents; Adrenergic Agonists; Amphetamine; Animals; Behavior, Addictive; Choice Behavior; Clonidine; Dopamine Agents; Dose-Response Relationship, Drug; Food; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Narcotic Antagonists; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Self Administration; Substance Withdrawal Syndrome | 2009 |
Involvement of NCAM and FGF receptor signaling in the development of analgesic tolerance to morphine.
Topics: Analgesics; Animals; Base Sequence; Chronic Pain; Drug Tolerance; Enzyme Activation; Gene Expression Regulation, Enzymologic; Male; Mice; Morphine; Neural Cell Adhesion Molecules; Oligonucleotides, Antisense; Protein Kinase C-alpha; Protein Kinase Inhibitors; Pyrroles; Receptors, Fibroblast Growth Factor; Receptors, Opioid, kappa; Signal Transduction; Time Factors | 2011 |
Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation.
Topics: Analgesics, Opioid; Animals; Autoradiography; Benzamides; Caudate Nucleus; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Dopamine Antagonists; Genes, fos; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Piperazines; Proto-Oncogene Proteins c-fos; Putamen; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Transcription Factors | 2011 |
Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Morphine; Motor Activity; Narcotics; Obsessive-Compulsive Disorder; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2012 |
Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc).
Topics: Animals; Corticosterone; Dopamine; Male; Morphine; Morphine Dependence; Naloxone; Neurons; Norepinephrine; Nucleus Accumbens; Phosphorylation; Proto-Oncogene Proteins c-fos; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Serine; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2012 |
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice.
Topics: Animals; Brain; Corpus Striatum; Genes, Immediate-Early; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Minocycline; Morphine; Motor Activity; Pyrroles; Species Specificity | 2012 |
Potential involvement of μ-opioid receptor dysregulation on the reduced antinociception of morphine in the inflammatory pain state in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Indoles; Inflammation; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Phosphorylation; Protein Kinase C-alpha; Pyrroles; Receptors, Opioid, mu; Spinal Cord | 2014 |
Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference.
Topics: Animals; Conditioning, Operant; Hormone Antagonists; Locus Coeruleus; Male; Mice; Morphine; Morphine Dependence; Narcotics; Neurons; Nucleus Accumbens; Pyrimidines; Pyrroles; Random Allocation; Receptors, Corticotropin-Releasing Hormone; Reward; Spatial Behavior; Ventral Tegmental Area | 2015 |
CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference.
Topics: Animals; Blotting, Western; Cells, Cultured; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Fluorescent Antibody Technique; Immunoenzyme Techniques; Male; Mice; Morphine; Morphine Dependence; Narcotics; Neurons; Phosphorylation; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Thioredoxins | 2015 |
Conditioned aversive memory associated with morphine withdrawal increases brain-derived neurotrophic factor in dentate gyrus and basolateral amygdala.
Topics: Affect; Analgesics, Opioid; Animals; Basolateral Nuclear Complex; Brain-Derived Neurotrophic Factor; Conditioning, Classical; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Extinction, Psychological; Male; Memory; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Naloxone; Narcotic Antagonists; Protein Precursors; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2020 |
Morphine induces the differentiation of T helper cells to Th2 effector cells via the PKC-θ-GATA3 pathway.
Topics: Analgesics, Opioid; Animals; Cell Differentiation; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Male; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Protein Kinase C-theta; Pyrroles; Quinazolines; T-Lymphocytes, Helper-Inducer | 2020 |
Ligand based conformational space studies of the μ-opioid receptor.
Topics: Amino Acids; Apoproteins; Binding Sites; Humans; Ligands; Lipid Bilayers; Molecular Docking Simulation; Molecular Dynamics Simulation; Morphinans; Morphine; Naloxone; Phosphatidylcholines; Protein Binding; Protein Conformation, alpha-Helical; Pyrroles; Receptors, Opioid, mu; Solutions; Water | 2021 |
Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Extinction, Psychological; Hypothalamo-Hypophyseal System; Male; Memory; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2021 |
Meconium corpuscles in intestinal epithelium of fetal and newborn primates.
Topics: Animals; Animals, Newborn; Epithelial Cells; Epithelium; Female; Fetal Death; Fetus; Haplorhini; Histocytochemistry; Ileum; Inclusion Bodies; Intestinal Mucosa; Intestine, Small; Lymph Nodes; Macaca mulatta; Meconium; Microscopy, Electron; Papio; Pigments, Biological; Pregnancy; Pyrroles | 1974 |
Changes in bilirubins in human prenatal development.
Topics: Azo Compounds; Bile; Bile Pigments; Bilirubin; Chromatography, Thin Layer; Diazonium Compounds; Gallbladder; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Intestines; Meconium; ortho-Aminobenzoates; Pyrroles | 1980 |