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pyrroles and morphine

pyrroles has been researched along with morphine in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199017 (26.56)18.7374
1990's17 (26.56)18.2507
2000's18 (28.13)29.6817
2010's8 (12.50)24.3611
2020's4 (6.25)2.80

Authors

AuthorsStudies
Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL2
Brice, AG; Cornfeldt, M; Forster, AM; Forster, HV; Forster, MA; Hubbard, JW; Locke, KW; Lowry, TF; Pan, LG; Vanselous, CL1
Cowan, A; Wheeler-Aceto, H2
Cowan, A; Ianone, M; Porreca, F; Wheeler, H1
Bovill, JG; Bravo, LJ; Burm, AG; Mattie, H; Spierdijk, J1
Bullingham, RE; Gillies, GW; Kenny, GN; McArdle, CS1
Fragen, RJ; Kinzer, M; O'Hara, DA; Pemberton, D1
Dhasmana, KM; Dixit, KS; Gupta, ML; Jaju, BP1
Della Bella, D; Ferrari, V; Frigeni, C; Lualdi, P1
Babbini, M; Bartoletti, M; Gaiardi, M1
Cheney, D; Costa, E; Revuelta, A1
Frigerio, G1
Gardocki, JF; Muschek, LD; Pruss, TP; Taylor, RJ1
Forrest, WH2
Jasinski, DR; Johnson, RE; Kocher, TR1
Blanchard, JC; Carruette, A; Garret, C; Laduron, PM; Montier, F; Moussaoui, SM1
Carruette, A; Garret, C; Moussaoui, S1
Funada, M; Kamei, J; Kawashima, N; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takamori, K1
Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Narita, M; Suzuki, T1
Nagasaka, H; Yaksh, TL1
Baeyens, JM; Barrios, M; Robles, LI1
Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Poggioli, R1
Baeyens, JM; Barrios, M; Ocaña, M1
Grouhel, A; Wettstein, JG1
Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ1
Farouz-Grant, F; Portoghese, PS1
Chakrabarti, S; Law, PY; Loh, HH1
Kamei, J; Ohsawa, M1
Ahlner, J; Förstberg-Peterson, S; Kågedal, B; Kronstrand, R; Larson, G1
Alvaro, JD; Chen, YL; Duman, RS; Iredale, PA; Lee, Y; Terwilliger, R1
Bordi, F; Quartaroli, M1
Ceng, X; Huang, M; Lu, L1
Ceng, X; Liu, D; Lu, L; Ma, L1
Bettelini, L; Corsi, M; Fasdelli, N; Maraia, G; Quartaroli, M1
Mizuo, K; Narita, M; Shibasaki, M; Suzuki, T1
Bordi, F; Cavallini, P; Cavanni, P; Di Fabio, R; Donati, D; Faedo, S; Maffeis, M; Micheli, F; Sabbatini, FM; Tarzia, G; Tranquillini, ME1
Dewey, WL; Elzey, MJ; Javed, RR; Smith, FL1
Kato, H; Narita, M; Oe, K; Shibasaki, M; Suzuki, T; Yajima, Y; Yamazaki, M1
Cador, M; Koob, GF; Stinus, L; Zorrilla, EP1
Dewey, WL; Javed, RR; Smith, FL; Smith, PA1
Blackburn-Munro, G; Bomholt, SF; Erichsen, HK1
Aceto, MD; Breeden, S; Husbands, SM; Ko, MC; Lewis, JW; Neilan, CL; Traynor, JR; Woods, JH1
Fang, Q; Liu, Z; Lu, L; Wang, J1
Dewey, WL; Gabra, BH; Javed, RR; Smith, FL; Smith, PA1
Ahmadiani, A; Esmaeili-Mahani, S; Javan, M; Koibuchi, N; Maghsoudi, N; Motamedi, F; Shimokawa, N1
Divin, MF; Holden Ko, MC; Traynor, JR1
Negus, SS; Rice, KC1
Fujita-Hamabe, W; Nakamoto, K; Tokuyama, S1
Agnati, LF; Brené, S; de la Calle, A; Fuxe, K; Gago, B; Reina-Sánchez, MD; Rivera, A; Rodríguez-Pérez, LM; Suárez-Boomgaard, D1
Bhutada, PS; Mundhada, YR; Umathe, SN1
Almela, P; García-Carmona, JA; Hidalgo, J; Laorden, ML; Milanés, MV; Mora, L; Navarro-Zaragoza, J1
Korostyński, M; Kubik, J; Piechota, M; Przewłocki, R; Ziółkowska, B1
Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Takeda, K; Watanabe, C1
Laorden, ML; Lasheras, MC; Milanés, MV; Núñez, C1
Almela, P; Camejo, DM; García-Carmona, JA; Jiménez, A; Laorden, ML; Milanés, MV; Sevilla, F1
Almela, P; Laorden, ML; Martínez-Laorden, E; Milanés, MV; Navarro-Zaragoza, J1
Han, C; He, L; Lei, D; Li, S; Liu, L; Ma, T; Wen, S; Xie, S; Zhou, H1
Cong, X; Giorgetti, A; Sena, DM1
Almela, P; Cánovas, A; Gómez-Murcia, V; Laorden, ML; Martínez-Laorden, E; Milanés, MV; Navarro-Zaragoza, J; Teruel-Fernández, FJ1
Blumenthal, S; Bronson, RT; Kanayama, R; Ruebner, BH1
Bergstrom, DE; Blumenthal, SG; Hanson, FW; Ikeda, RM; Rasmussen, RD; Ruebner, BH; Stucker, T1

Trials

8 trial(s) available for pyrroles and morphine

ArticleYear
The effects on ventilation of ketorolac in comparison with morphine.
    European journal of clinical pharmacology, 1988, Volume: 35, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Humans; Ketorolac; Male; Morphine; Pyrroles; Random Allocation; Respiration; Tolmetin

1988
The morphine sparing effect of ketorolac tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery.
    Anaesthesia, 1987, Volume: 42, Issue:7

    Topics: Abdomen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; Infusions, Parenteral; Ketorolac Tromethamine; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin; Tromethamine

1987
Ketorolac tromethamine as compared with morphine sulfate for treatment of postoperative pain.
    Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:5

    Topics: Adult; Aged; Drug Combinations; Female; Humans; Injections, Intramuscular; Ketorolac Tromethamine; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin; Tromethamine

1987
[Viminol in the treatment of pain. Double-blind, controlled, multicentric trial].
    Minerva medica, 1974, Feb-17, Volume: 65, Issue:12

    Topics: Aminopyrine; Analgesics; Aspirin; Benzoates; Benzyl Compounds; Dextropropoxyphene; Drug Evaluation; Drug Tolerance; Ethanolamines; Female; Humans; Male; Morphine; Nausea; Pain; Pentazocine; Phenylbutazone; Pyrroles; Sleep Wake Disorders; Vertigo

1974
Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain.
    JAMA, 1980, Nov-21, Volume: 244, Issue:20

    Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin

1980
Abuse potential of zomepirac.
    Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:3

    Topics: Blood Pressure; Drug Evaluation; Euphoria; Humans; Morphine; Pupil; Pyrroles; Substance-Related Disorders; Surveys and Questionnaires; Tolmetin

1983
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Administration, Oral; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injections, Intramuscular; Male; Morphine; Neoplasms; Pain, Postoperative; Pyrroles; Tolmetin

1980
Oral zomepirac and intramuscular morphine in postoperative pain.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Injections, Intramuscular; Morphine; Pain, Postoperative; Pyrroles; Time Factors; Tolmetin

1980

Other Studies

56 other study(ies) available for pyrroles and morphine

ArticleYear
Clinical analgesic assay of oral zomepirac and intramuscular morphine.
    NIDA research monograph, 1979, Volume: 27

    Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morphine; Pain; Pain, Postoperative; Pyrroles; Research Design; Tolmetin

1979
Cardiorespiratory effects of the novel opioid analgesic HP 736 in the anesthetized dog and conscious goat.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Analgesics, Opioid; Animals; Atropine; Carbon Dioxide; Dogs; Female; Goats; Hemodynamics; In Vitro Techniques; Indoles; Male; Mice; Morphine; Oxygen; Pyrroles; Rats; Rats, Inbred Strains; Respiration

1992
Involvement of a peripheral component in the antinociceptive effects of opioids in a model of tonic pain.
    NIDA research monograph, 1990, Volume: 105

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1990
Standardization of the rat paw formalin test for the evaluation of analgesics.
    Psychopharmacology, 1991, Volume: 104, Issue:1

    Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reference Standards; Thiophenes

1991
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats.
    Proceedings of the Western Pharmacology Society, 1989, Volume: 32

    Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes

1989
Role of central dopaminergic receptors in manic response of cats to morphine.
    Psychopharmacologia, 1972, Volume: 24, Issue:3

    Topics: Animals; Atropine; Bipolar Disorder; Cats; Central Nervous System; Chlorpromazine; Dopamine; Drug Antagonism; Female; Haloperidol; Histamine H1 Antagonists; Humans; Lysergic Acid Diethylamide; Male; Morphine; Phenoxybenzamine; Propranolol; Pyrroles; Receptors, Drug; Reserpine; Tetrabenazine

1972
Agonistic and antagonistic properties of diastereoisomers in a new central analgesic.
    Nature: New biology, 1973, Feb-28, Volume: 241, Issue:113

    Topics: Analgesics; Animals; Benzyl Compounds; Butylamines; Ethanolamines; Humans; Mice; Morphine; Nalorphine; Naloxone; Pyrroles; Stereoisomerism; Substance-Related Disorders

1973
Some behavioral and EEG effects of a new analgesic agent (viminol) in comparison with morphine in rats.
    European journal of pharmacology, 1973, Volume: 23, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Benzyl Compounds; Butylamines; Conditioning, Operant; Dose-Response Relationship, Drug; Electroencephalography; Ethanolamines; Humans; Lethal Dose 50; Locomotion; Male; Meperidine; Meprobamate; Methadone; Morphine; Pyrroles; Rats; Substance-Related Disorders; Time Factors

1973
Stereoisomers of viminol: catalepsy and brain monoamine turnover rate.
    Advances in biochemical psychopharmacology, 1973, Volume: 8, Issue:0

    Topics: Analgesics; Animals; Benzyl Compounds; Biogenic Amines; Brain; Brain Chemistry; Butylamines; Catalepsy; Catecholamines; Cerebellum; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Ethanolamines; Humans; Kinetics; Male; Mice; Morphine; Motor Activity; Neurons; Norepinephrine; Pyrroles; Rats; Serotonin; Stereoisomerism; Structure-Activity Relationship; Telencephalon; Time Factors

1973
Evaluation of the analgesic properties of zomepirac.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Analgesics; Animals; Cattle; Cyclooxygenase Inhibitors; Drug Interactions; Hindlimb; Humans; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Platelet Aggregation; Pyrroles; Reaction Time; Receptors, Opioid; Substance-Related Disorders; Tolmetin

1980
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Electric Stimulation; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Morphine; Mucus; Nasal Mucosa; Pyrroles; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synapses; Thiophenes; Xylenes

1993
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes

1993
Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice.
    Psychopharmacology, 1993, Volume: 113, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Cromakalim; Glyburide; Injections, Intraventricular; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Morphine; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord; Stimulation, Chemical

1993
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
    Psychopharmacology, 1994, Volume: 113, Issue:3-4

    Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Tetraethylammonium Compounds

1994
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats.
    Anesthesia and analgesia, 1995, Volume: 80, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes

1995
ATP-sensitive K+ channel openers inhibit morphine withdrawal.
    European journal of pharmacology, 1994, Jan-04, Volume: 251, Issue:1

    Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Benzopyrans; Body Weight; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Morphine; Naloxone; Potassium Channels; Pyrroles; Substance Withdrawal Syndrome

1994
K+ channel openers delay intestinal transit and have antidiarrheal activity.
    European journal of pharmacology, 1995, Dec-12, Volume: 287, Issue:2

    Topics: Animals; Benzopyrans; Cromakalim; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guanidines; Male; Mice; Mice, Inbred Strains; Morphine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents

1995
Cromakalim differentially enhances antinociception induced by agonists of alpha(2)adrenoceptors, gamma-aminobutyric acid(B), mu and kappa opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:3

    Topics: Animals; Baclofen; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain; Pyrroles; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents

1996
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
    Life sciences, 1997, Volume: 60, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1997
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.
    Journal of medicinal chemistry, 1997, Jun-20, Volume: 40, Issue:13

    Topics: Animals; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Chemical; Morphinans; Morphine; Muscle, Smooth; Pyrroles; Receptors, Opioid, delta; Stereoisomerism

1997
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Analgesics, Opioid; Antibody Specificity; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Indoles; Morphine; Neuroblastoma; Neurons; Phosphorylation; Precipitin Tests; Pyrroles; Receptors, Opioid, mu; Tumor Cells, Cultured

1998
Modification of the expression of naloxone-precipitated withdrawal signs in morphine-dependent mice by diabetes: possible involvement of protein kinase C.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:3

    Topics: Animals; Behavior, Animal; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Frontal Lobe; Indoles; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Substance Withdrawal Syndrome

1999
Codeine concentration in hair after oral administration is dependent on melanin content.
    Clinical chemistry, 1999, Volume: 45, Issue:9

    Topics: Chromatography, High Pressure Liquid; Codeine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Melanins; Morphine; Narcotics; Pyrroles; Substance Abuse Detection

1999
Role of corticotropin-releasing factor receptor-1 in opiate withdrawal.
    Journal of neurochemistry, 2000, Volume: 74, Issue:1

    Topics: Animals; Behavior, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Protein Isoforms; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome

2000
Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus.
    Pain, 2000, Volume: 84, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hot Temperature; Indoles; Male; Morphine; Nerve Compression Syndromes; Neurons; Nociceptors; Pain Measurement; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reference Values; Sciatic Nerve; Synaptic Transmission; Touch; Ventral Thalamic Nuclei

2000
Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats.
    Neuroreport, 2000, Aug-03, Volume: 11, Issue:11

    Topics: Animals; Behavior, Animal; Conditioning, Psychological; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Morphine; Neuropsychological Tests; Opioid-Related Disorders; Psychomotor Performance; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Secondary Prevention; Stress, Physiological

2000
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence.
    The European journal of neuroscience, 2000, Volume: 12, Issue:12

    Topics: Animals; Cerebral Ventricles; Choice Behavior; Corticotropin-Releasing Hormone; Hormone Antagonists; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Naloxone; Peptide Fragments; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome

2000
GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Animals; Behavior, Animal; Binding Sites; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Indoles; Ligation; Male; Mice; Morphine; Narcotics; Neuralgia; Pain; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Stress, Mechanical

2001
Up-regulation of the G(q/11alpha) protein and protein kinase C during the development of sensitization to morphine-induced hyperlocomotion.
    Neuroscience, 2002, Volume: 111, Issue:1

    Topics: Animals; Disease Susceptibility; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Hyperkinesis; Indoles; Limbic System; Male; Mesencephalon; Mice; Morphine; Narcotics; Prosencephalon; Protein Isoforms; Protein Kinase C; Pyrroles; RGS Proteins; Up-Regulation

2002
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships.
    Bioorganic & medicinal chemistry letters, 2003, Jul-07, Volume: 13, Issue:13

    Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Electrophysiology; Esters; Excitatory Amino Acid Antagonists; Indicators and Reagents; Morphine; Neurons; Nociceptors; Pyrroles; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Structure-Activity Relationship; Synaptic Transmission; Thalamus

2003
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.
    Brain research, 2003, Sep-19, Volume: 985, Issue:1

    Topics: Analgesics; Animals; Brain; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoquinolines; Male; Maleimides; Mice; Morphine; Morphine Dependence; Pain; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrroles

2003
Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice.
    Neuroscience, 2004, Volume: 125, Issue:3

    Topics: Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Indoles; Ligation; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Neuralgia; Protein Kinase C; Pyrroles; Reward; Sciatic Neuropathy; Spinal Cord; Up-Regulation

2004
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1

    Topics: Acamprosate; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Avoidance Learning; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Implants; Fluoxetine; Lisuride; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome; Taurine

2005
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice.
    European journal of pharmacology, 2004, May-25, Volume: 492, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Tolerance; Hypothermia, Induced; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Maleimides; Mice; Morphine; Pain Measurement; Protein Kinase C; Pyrroles; Tail

2004
Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain.
    Neuropharmacology, 2004, Volume: 47, Issue:3

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Kainic Acid; Tetrahydroisoquinolines; Time Factors

2004
Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
    European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2

    Topics: Analgesics; Animals; Binding, Competitive; Buprenorphine; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Pain; Pain Measurement; Pyrroles; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors; Tritium; Vas Deferens

2004
Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats.
    Psychopharmacology, 2006, Volume: 185, Issue:1

    Topics: Amygdala; Animals; Behavior, Animal; Brain; Central Nervous System Agents; Cocaine; Conditioning, Operant; Extinction, Psychological; Heroin; Injections, Intraventricular; Learning; Male; Morphine; Nucleus Accumbens; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Reinforcement, Psychology; Septal Nuclei; Stress, Psychological

2006
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
    Pharmacological research, 2006, Volume: 54, Issue:6

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Drug Implants; Drug Tolerance; Enzyme Inhibitors; Hot Temperature; Hypothermia; Indoles; Injections, Intraventricular; Isoquinolines; Male; Maleimides; Mice; Morphine; Pain; Protein Kinase C; Pyrroles; Reaction Time

2006
Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.
    Journal of neuroscience research, 2008, Feb-01, Volume: 86, Issue:2

    Topics: Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression; GTP-Binding Proteins; Hyperalgesia; Immunoblotting; Indoles; Male; Morphine; Nifedipine; Polymerase Chain Reaction; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord

2008
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Animals; Binding, Competitive; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pyrroles; Receptors, Opioid, mu; Substance Withdrawal Syndrome

2008
Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:4

    Topics: Adrenergic Agents; Adrenergic Agonists; Amphetamine; Animals; Behavior, Addictive; Choice Behavior; Clonidine; Dopamine Agents; Dose-Response Relationship, Drug; Food; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Narcotic Antagonists; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Self Administration; Substance Withdrawal Syndrome

2009
Involvement of NCAM and FGF receptor signaling in the development of analgesic tolerance to morphine.
    European journal of pharmacology, 2011, Dec-15, Volume: 672, Issue:1-3

    Topics: Analgesics; Animals; Base Sequence; Chronic Pain; Drug Tolerance; Enzyme Activation; Gene Expression Regulation, Enzymologic; Male; Mice; Morphine; Neural Cell Adhesion Molecules; Oligonucleotides, Antisense; Protein Kinase C-alpha; Protein Kinase Inhibitors; Pyrroles; Receptors, Fibroblast Growth Factor; Receptors, Opioid, kappa; Signal Transduction; Time Factors

2011
Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation.
    Brain research, 2011, Aug-17, Volume: 1407

    Topics: Analgesics, Opioid; Animals; Autoradiography; Benzamides; Caudate Nucleus; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Dopamine Antagonists; Genes, fos; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Piperazines; Proto-Oncogene Proteins c-fos; Putamen; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Transcription Factors

2011
Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal.
    Neuropeptides, 2012, Volume: 46, Issue:5

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Morphine; Motor Activity; Narcotics; Obsessive-Compulsive Disorder; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome

2012
Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc).
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Animals; Corticosterone; Dopamine; Male; Morphine; Morphine Dependence; Naloxone; Neurons; Norepinephrine; Nucleus Accumbens; Phosphorylation; Proto-Oncogene Proteins c-fos; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Serine; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase; Ventral Tegmental Area

2012
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:5

    Topics: Animals; Brain; Corpus Striatum; Genes, Immediate-Early; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Minocycline; Morphine; Motor Activity; Pyrroles; Species Specificity

2012
Potential involvement of μ-opioid receptor dysregulation on the reduced antinociception of morphine in the inflammatory pain state in mice.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:2

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Indoles; Inflammation; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Phosphorylation; Protein Kinase C-alpha; Pyrroles; Receptors, Opioid, mu; Spinal Cord

2014
Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference.
    Neuropharmacology, 2015, Volume: 95

    Topics: Animals; Conditioning, Operant; Hormone Antagonists; Locus Coeruleus; Male; Mice; Morphine; Morphine Dependence; Narcotics; Neurons; Nucleus Accumbens; Pyrimidines; Pyrroles; Random Allocation; Receptors, Corticotropin-Releasing Hormone; Reward; Spatial Behavior; Ventral Tegmental Area

2015
CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Animals; Blotting, Western; Cells, Cultured; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Fluorescent Antibody Technique; Immunoenzyme Techniques; Male; Mice; Morphine; Morphine Dependence; Narcotics; Neurons; Phosphorylation; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Thioredoxins

2015
Conditioned aversive memory associated with morphine withdrawal increases brain-derived neurotrophic factor in dentate gyrus and basolateral amygdala.
    Addiction biology, 2020, Volume: 25, Issue:4

    Topics: Affect; Analgesics, Opioid; Animals; Basolateral Nuclear Complex; Brain-Derived Neurotrophic Factor; Conditioning, Classical; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Extinction, Psychological; Male; Memory; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Naloxone; Narcotic Antagonists; Protein Precursors; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome

2020
Morphine induces the differentiation of T helper cells to Th2 effector cells via the PKC-θ-GATA3 pathway.
    International immunopharmacology, 2020, Volume: 80

    Topics: Analgesics, Opioid; Animals; Cell Differentiation; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Male; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Protein Kinase C-theta; Pyrroles; Quinazolines; T-Lymphocytes, Helper-Inducer

2020
Ligand based conformational space studies of the μ-opioid receptor.
    Biochimica et biophysica acta. General subjects, 2021, Volume: 1865, Issue:3

    Topics: Amino Acids; Apoproteins; Binding Sites; Humans; Ligands; Lipid Bilayers; Molecular Docking Simulation; Molecular Dynamics Simulation; Morphinans; Morphine; Naloxone; Phosphatidylcholines; Protein Binding; Protein Conformation, alpha-Helical; Pyrroles; Receptors, Opioid, mu; Solutions; Water

2021
Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 201

    Topics: Animals; Avoidance Learning; Conditioning, Operant; Extinction, Psychological; Hypothalamo-Hypophyseal System; Male; Memory; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome

2021
Meconium corpuscles in intestinal epithelium of fetal and newborn primates.
    Archives of pathology, 1974, Volume: 98, Issue:6

    Topics: Animals; Animals, Newborn; Epithelial Cells; Epithelium; Female; Fetal Death; Fetus; Haplorhini; Histocytochemistry; Ileum; Inclusion Bodies; Intestinal Mucosa; Intestine, Small; Lymph Nodes; Macaca mulatta; Meconium; Microscopy, Electron; Papio; Pigments, Biological; Pregnancy; Pyrroles

1974
Changes in bilirubins in human prenatal development.
    The Biochemical journal, 1980, Mar-15, Volume: 186, Issue:3

    Topics: Azo Compounds; Bile; Bile Pigments; Bilirubin; Chromatography, Thin Layer; Diazonium Compounds; Gallbladder; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Intestines; Meconium; ortho-Aminobenzoates; Pyrroles

1980