Page last updated: 2024-08-18

pyrroles and ml-3000

pyrroles has been researched along with ml-3000 in 103 studies

Research

Studies (103)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (8.74)	18.2507
2000's	52 (50.49)	29.6817
2010's	38 (36.89)	24.3611
2020's	4 (3.88)	2.80

Authors

Authors	Studies
Carter, L; Laufer, S; McKnight, W; Tries, S; Wallace, JL	1
Algate, DR; Atterson, PR; Augustin, J; Beard, DJ; Jobling, CM; Laufer, S; Munt, PL; Tries, S	1
Deigner, HP; Freyberg, CE; Laufer, S	1
Augustin, J; Heidemann, A; Laufer, S; Tries, S	1
Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Laufer, S; Munt, PL; Tries, S	1
Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S	1
Augustin, J; Dannhardt, G; Laufer, S; Tries, S	1
Claus, R; Deigner, HP; Fyrnys, B; Wolf, G	1
Abraham, WM; Laufer, S; Tries, S	1
Gay, RE; Gay, S; Laufer, S; Neidhart, M; Pataky, F; Tries, S	1
Fernandes, JC; Jolicoeur, FC; Jovanovic, DV; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P; Tries, S	1
Breddin, HK; Laufer, S; Radziwon, P; Tries, S	1
Laufer, S; Neupert, W; Tries, S	1
Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP	1
Boileau, C; Jouzeau, JY; Laufer, S; Martel-Pelletier, J; Moldovan, F; Netter, P; Pelletier, JP; Tries, S	1
Cerletti, C; Dell'Elba, G; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Martelli, N; Pecce, R; Rotondo, S	1
Barbanti, M; de Lima, OM; Distrutti, E; Fiorucci, S; Mencarelli, A; Morelli, A; Palazzini, E; Romano, M; Wallace, JL	1
Hawkey, CJ; Skelly, MM	1
Laufer, S	1
Evans, R	1
Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL	1
Cicuttini, F; Ding, C	1
Celotti, F; Durand, T	1
Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP	1
Bannwarth, B	1
Brune, K	1
Alvaro-Gracia, JM	1
Boileau, C; Boily, M; Brunet, J; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P	1
Goldenring, JR; Gupta, S; Hammond, CE; Smolka, AJ	1
Cerletti, C; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Rotondo, S	1
Bias, P; Buchner, A; Klesser, B; Laufer, S	1
Boileau, C; Fahmi, H; Laufer, S; Lavigne, M; Martel-Pelletier, J; Pelletier, JP; Tardif, G	1
Daminet, S; Fernandes, J; Martel-Pelletier, J; Moreau, M; Pelletier, JP	1
Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P	1
Kulkarni, SK; Patil, CS; Singh, VP	2
Naveau, B	1
Albrecht, W; Dannhardt, G; Eriksson, EE; Laufer, S; Lindbom, L; Soehnlein, O; Ulbrich, H; Xie, X	1
Cicero, AF; Derosa, G; Gaddi, A	1
Boileau, C; Boily, M; Brunet, J; Geng, C; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P	1
Boileau, C; Brunet, J; Laufer, S; Martel-Pelletier, J; Moreau, M; Pelletier, JP	1
Cerletti, C; Dell'Elba, G; Evangelista, V; Manarini, S; Rotondo, S	1
Egido, J; Gómez-Gerique, JA; Gómez-Hernández, A; González, A; Ortega, L; Sánchez-Galán, E; Tuñón, J; Vidal, C	1
Arderiu, G; Escolar, G; Hernandez, MR; Pedreño, J; Pino, M; Salas, E; Serradell, M; Tonda, R	1
Hampton, T	1
Kulkarni, SK; Singh, VP	2
Doucet, M; Lussier, B; Martel-Pelletier, J; Moreau, M; Pelletier, JP; Vincent, G	1
Gay, RE; Gay, S; Kurowska-Stolarska, M; Laufer, S; Michel, BA; Neidhart, M; Ospelt, C	1
Dodt, G; Fischer, L; Franke, L; Hornig, M; Meindl, N; Pergola, C; Schneider, G; Steinhilber, D; Tanrikulu, Y; Werz, O	1
Martel-Pelletier, J; Pelletier, JP	1
Coruzzi, G; Spaggiari, S; Venturi, N	1
Bartolini, G; Bonafè, M; Brighenti, E; Ferreri, C; Guarnieri, T; Laufer, S; Manara, S; Marini, M; Tavolari, S; Tomasi, V	1
Cicero, AF; Laghi, L	1
Albrecht, W; Laufer, S; Nussler, AK; Unger, A	1
Klein, T; Pushkareva, MA; Shephard, P; Sud'ina, GF	1
Albrecht, W; Bühring, U; Koeberle, A; Laufer, S; Northoff, H; Siemoneit, U; Werz, O	1
Abram, F; Beaulieu, AD; Bias, P; Choquette, D; Dorais, M; Haraoui, B; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP; Vignon, E	1
Abram, F; Bias, P; Choquette, D; Dorais, M; Emmert, KH; Haraoui, B; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP	1
Abram, F; Caron, J; Choquette, D; Dorais, M; Haraoui, B; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Raynauld, JP	1
Abram, F; Dorais, M; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP; Wildi, LM	1
Gupta, A; Kulkarni, SK; Kumar, A	1
Kalonia, H; Kumar, A; Kumar, P	2
Bensdorf, K; Guo, C; Gust, R; Huang, W; Liu, H; Liu, W; Qian, H; Rubner, G; Wang, Y; Wellner, A; Zhang, H; Zhang, Y; Zhou, J	1
Dzielska-Olczak, M	1
Abram, F; Choquette, D; Dorais, M; Haraoui, B; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP; Wildi, LM	1
Lee, J; Sharma, S; Steele, VE; Zhou, J	1
Bensdorf, K; Guo, C; Gust, R; Liu, H; Liu, W; Liu, Y; Zhou, J	1
Choi, CI; Janakiram, NB; Li, Q; Mohammed, A; Rao, CV; Steele, VE; Zhang, Y	1
Chieco, P; Guarnieri, T; Laufer, S; Munarini, A; Storci, G; Tavolari, S	1
Gao, Y; He, C; He, S; Lai, L; Liu, Y; Wu, Y	1
Chen, H; Wu, YJ; Xue, M	1
Dulin, JN; Grill, RJ; Moore, ML	1
Korostyński, M; Kubik, J; Piechota, M; Przewłocki, R; Ziółkowska, B	1
Kalonia, H; Kumar, A; Kumar, P; Mishra, J; Vashist, A	1
Dulin, JN; Grill, RJ; Karoly, ED; Strobel, HW; Wang, Y	1
Brewer, M; Janakiram, NB; Mohammed, A; Rao, CV; Steele, VE; Vedala, K	1
Kabadere, S; Kus, G; Oztopcu-Vatan, P; Uyar, R	2
Hofmann, B; Steinhilber, D	1
Meirer, K; Proschak, E; Steinhilber, D	1
Biddick, L; Kopelovich, L; Li, Q; Lightfoot, S; Madka, V; Mohammed, A; Patlolla, JM; Rao, CV; Steele, V; Wu, XR; Zhang, Y	1
Lu, R; Lv, P; Su, W; Zhang, K; Zhao, J	1
Deshmukh, R; Kumar, A; Prashar, A; Sharma, S	1
Bedi, A; Davis, ME; Flood, MD; Gumucio, JP; Harning, JA; Lynch, EB; Mendias, CL; Oak, NR; Roche, SM; Saripalli, AL	1
Balansky, R; D'Agostini, F; De Flora, S; Ganchev, G; Iltcheva, M; La Maestra, S; Micale, RT; Nikolov, M; Steele, VE	1
Brewer, M; Cruz-Monserrate, Z; Houchen, CW; Janakiram, NB; Kumar, G; Lightfoot, S; Madka, V; May, R; Mohammed, A; Patlolla, JM; Rao, CV; Ritchie, RL; Sadeghi, M; Steele, VE; Yamada, HY	1
Attar, H; Bahremand, A; Bahremand, T; Dehpour, AR; Gholizadeh, R; Khoshneviszadeh, M; Payandemehr, B; Varastehmoradi, B	1
Biddick, L; Brewer, M; Devarkonda, V; Janakiram, NB; Lightfoot, S; Madka, V; Mohammed, A; Rao, CV; Steele, VE	1
Dehm, F; Gerstmeier, J; Koeberle, A; Laufer, S; Maier, TJ; Northoff, H; Pace, S; Pein, H; Pergola, C; Rådmark, O; Rossi, A; Rummler, S; Samuelsson, B; Sautebin, L; Schaible, AM; Troisi, F; Weinigel, C; Werz, O	1
Kaur, G; Silakari, O	1
Poorvashree, J; Suneela, D	1
Dehpour, AR; Fakhraei, N; Ghasemkhani, N; Mokhtari, R; Mousavi, SE; Saberi, P	1
Cuccovia, IM; Fontaine, P; Lopes-de-Campos, D; Nunes, C; Pereira-Leite, C; Reis, S	1
Chamorro-Cevallos, GA; Cristobal-Luna, JM; Delgado, F; Escalante, CH; Esquivel-Campos, AL; Gómez-García, O; Gutiérrez-Rebolledo, GA; Hernández-Benitez, RI; Madrigal, DA; Pérez-Gutiérrez, S; Tamariz, J	1
Balansky, R; De Flora, S; Izzotti, A; La Maestra, S; Micale, RT; Pulliero, A	1
Liu, M; Martel-Pelletier, J; Pelletier, JP; Rahman, P; Randell, EW; Zhai, G	1
Aman, W; Dehpour, AR; Khan, MI; Mehrzadi, S; Nikoui, V; Ostadhadi, S	1
Dearth, CL; Goldman, SM; Janakiram, NB; Valerio, MS	1
Abdolghaffari, AH; Arab, ZN; Dehpour, AR; Jafari, RM; Khayatan, D; Momtaz, S; Razavi, SM; Zare, K	1

Reviews

18 review(s) available for pyrroles and ml-3000

Article	Year
ML 3000. Drugs in R&D, 2002, Volume: 3, Issue:3 Topics: Acetates; Animals; Clinical Trials as Topic; Drug Industry; Humans; Lung Diseases, Obstructive; Pyrroles; Rheumatic Diseases	2002
COX-LOX inhibition: current evidence for an emerging new therapy. International journal of clinical practice, 2003, Volume: 57, Issue:4 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Dogs; Humans; Intestinal Mucosa; Leukotrienes; Lipoxygenase Inhibitors; Models, Animal; Peptic Ulcer; Prostaglandins; Pyrroles; Rats; Sheep	2003
Licofelone (Merckle). IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:8 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Structure-Activity Relationship	2003
The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy. Prostaglandins & other lipid mediators, 2003, Volume: 71, Issue:3-4 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cardiovascular System; Clinical Trials, Phase III as Topic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Intestinal Mucosa; Isoenzymes; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrroles	2003
Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy? Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:1 Topics: Acetates; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Digestive System; Eicosanoids; Humans; Kidney Function Tests; Lipoxygenase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles; Randomized Controlled Trials as Topic	2004
Safety of anti-inflammatory treatment--new ways of thinking. Rheumatology (Oxford, England), 2004, Volume: 43 Suppl 1 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Gastrointestinal Diseases; Humans; Isoenzymes; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles	2004
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford, England), 2004, Volume: 43 Suppl 1 Topics: Acetates; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Combinations; Gastrointestinal Diseases; Humans; Isoenzymes; Lipoxygenase Inhibitors; Long-Term Care; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrroles; Sulfonamides	2004
Combined lipoxygenase/cyclo-oxygenase inhibition in the elderly: the example of licofelone. Drugs & aging, 2005, Volume: 22, Issue:5 Topics: Acetates; Aged; Animals; Clinical Trials as Topic; Comorbidity; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles	2005
Licofelone--a novel analgesic and anti-inflammatory agent. Current topics in medicinal chemistry, 2007, Volume: 7, Issue:3 Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles	2007
DMOAD developments: present and future. Bulletin of the NYU hospital for joint diseases, 2007, Volume: 65, Issue:3 Topics: Acetates; Anthraquinones; Antirheumatic Agents; Chondroitin; Clinical Trials as Topic; Diphosphonates; Disease Progression; Doxycycline; Glucosamine; Humans; Hyaluronic Acid; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles; Risk Factors	2007
Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond. Acta bio-medica : Atenei Parmensis, 2007, Volume: 78, Issue:2 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Colon; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Humans; Hydrogen Sulfide; Lipoxins; Lipoxygenase Inhibitors; Nitric Oxide; Nitric Oxide Donors; Protein Isoforms; Pyrroles; Safety	2007
Activity and potential role of licofelone in the management of osteoarthritis. Clinical interventions in aging, 2007, Volume: 2, Issue:1 Topics: Acetates; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Treatment Outcome	2007
Licofelone: the answer to unmet needs in osteoarthritis therapy? Current rheumatology reports, 2008, Volume: 10, Issue:1 Topics: Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Eicosanoids; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles	2008
[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 30, Issue:175 Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles	2011
Recent advances in the search for novel 5-lipoxygenase inhibitors. Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1 Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Computational Biology; Drug Design; Humans; Leukotrienes; Lipoxygenase Inhibitors; Pyrroles; Rhinitis, Allergic; Rhinitis, Allergic, Perennial	2014
Inhibitors of the arachidonic acid cascade: interfering with multiple pathways. Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1 Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Humans; Inflammation; Lipoxygenase Inhibitors; Pain; Pyrroles	2014
Multiple target-centric strategy to tame inflammation. Future medicinal chemistry, 2017, Volume: 9, Issue:12 Topics: Cyclooxygenase Inhibitors; Humans; Inflammation; Lactones; Lipoxygenase; Lipoxygenase Inhibitors; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Pyrroles; Structure-Activity Relationship; Sulfones	2017
Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders. Prostaglandins & other lipid mediators, 2021, Volume: 157 Topics: Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Nervous System Diseases; Pyrroles	2021

Trials

9 trial(s) available for pyrroles and ml-3000

Article	Year
The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial. The American journal of gastroenterology, 2004, Volume: 99, Issue:4 Topics: Acetates; Adult; Cyclooxygenase Inhibitors; Duodenoscopy; Duodenum; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Naproxen; Peptic Ulcer; Pyrroles	2004
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs. Journal of veterinary pharmacology and therapeutics, 2005, Volume: 28, Issue:1 Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dogs; Double-Blind Method; Duodenoscopy; Duodenum; Gastroscopy; Lactones; Lipoxygenase Inhibitors; Pyrroles; Stomach; Sulfones; Treatment Outcome	2005
Efficacy of licofelone in dogs with clinical osteoarthritis. The Veterinary record, 2007, Apr-28, Volume: 160, Issue:17 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Double-Blind Method; Female; Gait; Lameness, Animal; Male; Osteoarthritis; Pyrroles	2007
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI. Annals of the rheumatic diseases, 2009, Volume: 68, Issue:6 Topics: Aged; Antirheumatic Agents; Cartilage, Articular; Chi-Square Distribution; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Knee Joint; Lipoxygenase Inhibitors; Magnetic Resonance Imaging; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Pain Measurement; Pyrroles; Radiography; Treatment Outcome	2009
Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis. Arthritis research & therapy, 2008, Volume: 10, Issue:6 Topics: Cartilage, Articular; Double-Blind Method; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Pyrroles; Sensitivity and Specificity	2008
Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis. Annals of the rheumatic diseases, 2010, Volume: 69, Issue:12 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; C-Reactive Protein; Cartilage, Articular; Drug Monitoring; Female; Humans; Magnetic Resonance Imaging; Male; Matrix Metalloproteinases; Middle Aged; Naproxen; Osteoarthritis, Knee; Pyrroles; Severity of Illness Index; Treatment Outcome	2010
Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI. Annals of the rheumatic diseases, 2010, Volume: 69, Issue:12 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Diseases; Cartilage, Articular; Cyclooxygenase Inhibitors; Epidemiologic Methods; Female; Humans; Knee Joint; Magnetic Resonance Imaging; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Pain; Pain Measurement; Pyrroles	2010
Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation. Annals of the rheumatic diseases, 2011, Volume: 70, Issue:8 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; C-Reactive Protein; Disease Progression; Epidemiologic Methods; Female; Humans; Knee Joint; Magnetic Resonance Imaging; Male; Menisci, Tibial; Middle Aged; Naproxen; Osteoarthritis, Knee; Prognosis; Pyrroles; Tibial Meniscus Injuries	2011
Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients. Arthritis research & therapy, 2019, 11-06, Volume: 21, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cyclooxygenase Inhibitors; Female; Humans; Lysophosphatidylcholines; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Phosphatidylcholines; Pyrroles; Treatment Outcome	2019

Other Studies

76 other study(ies) available for pyrroles and ml-3000

Article	Year
ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury. European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cyclooxygenase Inhibitors; Gastric Mucosa; Leukocytes; Lipoxygenase Inhibitors; Male; Prostaglandins; Pyrroles; Rabbits; Rats; Rats, Wistar; Stomach Ulcer	1994
General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals. Arzneimittel-Forschung, 1995, Volume: 45, Issue:2 Topics: Acetates; Animals; Behavior, Animal; Cats; Central Nervous System; Digestive System; Dogs; Female; Guinea Pigs; Hemodynamics; Kidney; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Pyrroles; Rats; Rats, Wistar; Respiratory System	1995
Distribution and excretion of [14C]-labelled [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5- yl]- [2'-14C]-acetic acid in rats. Arzneimittel-Forschung, 1995, Volume: 45, Issue:3 Topics: Acetates; Animals; Autoradiography; Chromatography, High Pressure Liquid; Feces; Female; Isotope Labeling; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Pyrroles; Rats; Rats, Inbred Strains; Tissue Distribution	1995
Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6- (4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittel-Forschung, 1995, Volume: 45, Issue:4 Topics: Acetates; Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Repair; Female; Lipoxygenase Inhibitors; Male; Mutagenicity Tests; Mutagens; Pyrroles; Rats; Rats, Wistar; Salmonella typhimurium	1995
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12 Topics: Acetates; Animals; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pyrroles; Rats; Rats, Wistar	1994
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittel-Forschung, 1995, Volume: 45, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar	1995
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase. Arzneimittel-Forschung, 1994, Volume: 44, Issue:5 Topics: Acetates; Animals; Arachidonic Acid; Arthritis, Experimental; Benzoquinones; Blood Coagulation; Bronchoconstriction; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Guinea Pigs; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Pain Measurement; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Yeast, Dried	1994
Oxidized low density lipoprotein stimulates protein kinase C (PKC) activity and expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 cells. Advances in experimental medicine and biology, 1997, Volume: 407 Topics: Acetates; Animals; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Induction; Indomethacin; Isoenzymes; Leukemia P388; Lipoproteins, LDL; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neoplasm Proteins; Nitrobenzenes; Oxidation-Reduction; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Serum Albumin, Bovine; Sulfonamides	1997
The effects of ML 3000 on antigen-induced responses in sheep. Pulmonary pharmacology & therapeutics, 1997, Volume: 10, Issue:3 Topics: Acetates; Aerosols; Animals; Antigens; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclooxygenase Inhibitors; Female; Hypersensitivity, Delayed; Lipoxygenase Inhibitors; Pyrroles; Sheep	1997
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis. The Journal of rheumatology, 2001, Volume: 28, Issue:9 Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Lipoxygenase Inhibitors; Probability; Prostaglandin-Endoperoxide Synthases; Pyrroles; Range of Motion, Articular; Rats; Rats, Inbred Lew; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome	2001
[Double blockade should protect the stomach. New approach to rheumatism]. MMW Fortschritte der Medizin, 2001, Sep-20, Volume: 143, Issue:38 Topics: Acetates; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Stomach Ulcer	2001
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis. Arthritis and rheumatism, 2001, Volume: 44, Issue:10 Topics: Acetates; Animals; Collagenases; Cyclooxygenase Inhibitors; Dogs; Interleukin-1; Lipoxygenase; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles	2001
Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibrinolytic Agents; Lipoxygenase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar	2002
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:3 Topics: Acetates; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Humans; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach; Thromboxane B2	2002
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition. Arthritis and rheumatism, 2002, Volume: 46, Issue:7 Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides	2002
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. The Journal of rheumatology, 2002, Volume: 29, Issue:7 Topics: Acetates; Administration, Oral; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 1; Nitric Oxide Synthase; Osteoarthritis; Probability; Pyrroles; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric	2002
Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function. European journal of pharmacology, 2002, Oct-18, Volume: 453, Issue:1 Topics: Acetates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Neutrophils; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Pyrroles	2002
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:9 Topics: Acetates; Acetylation; Adaptation, Physiological; Animals; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Hydroxyeicosatetraenoic Acids; Isoenzymes; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats	2003
International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium. Expert opinion on investigational drugs, 2003, Volume: 12, Issue:7 Topics: Acetates; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nitric Oxide Donors; Osteoarthritis; Pyrroles	2003
Anti arthritic drugs--SMi conference: dual inhibitors. 28-29 April 2003, London, UK. IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:6 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis; Clinical Trials as Topic; Complement Activation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha	2003
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin. British journal of pharmacology, 2003, Volume: 139, Issue:7 Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation	2003
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:1 Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator	2004
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone, 2004, Volume: 34, Issue:3 Topics: Acetates; Animals; Bone Resorption; Cathepsin K; Cathepsins; Collagenases; Dogs; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles	2004
Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC gastroenterology, 2004, Feb-10, Volume: 4 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Enzyme Inhibitors; Gastric Mucosa; Humans; Hydrochloric Acid; Interleukin-1; Interleukin-8; Omeprazole; Parietal Cells, Gastric; Proton Pump Inhibitors; Pyrroles; Rabbits	2004
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation. European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3 Topics: Acetates; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Humans; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinolines; Thrombin; Thromboxane B2	2004
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway. Annals of the rheumatic diseases, 2005, Volume: 64, Issue:6 Topics: Acetates; Aged; Cells, Cultured; Chondrocytes; Collagenases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Interleukin-1; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Middle Aged; Osteoarthritis, Knee; Promoter Regions, Genetic; Pyrroles; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic	2005
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. The Journal of rheumatology, 2005, Volume: 32, Issue:4 Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane	2005
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. Indian journal of experimental biology, 2005, Volume: 43, Issue:3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indomethacin; Inflammation; Leukotriene B4; Lipid Peroxidation; Male; Mesentery; Mice; Neutrophils; Pyrroles; Rats; Stomach Ulcer; Time Factors	2005
Dual inhibition of cyclo-oxygenases and 5-lipoxygenase: a novel therapeutic approach to inflammation? Joint bone spine, 2005, Volume: 72, Issue:3 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles	2005
Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow. Biochemical pharmacology, 2005, Jul-01, Volume: 70, Issue:1 Topics: Acetates; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Leukocytes; Lipoxygenase Inhibitors; Pyrroles; RNA, Messenger	2005
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis research & therapy, 2005, Volume: 7, Issue:5 Topics: Acetates; ADAM Proteins; ADAMTS4 Protein; Animals; Anterior Cruciate Ligament; Arachidonate 5-Lipoxygenase; Cathepsin K; Cathepsins; Collagenases; Cyclooxygenase Inhibitors; Dogs; Down-Regulation; Drug Evaluation; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Lipoxygenase Inhibitors; Matrix Metalloproteinase 13; Osteoarthritis; Procollagen N-Endopeptidase; Pyrroles; RNA, Messenger	2005
Anti-inflammatory effect of licofelone against various inflammatory challenges. Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch	2006
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. The Journal of rheumatology, 2006, Volume: 33, Issue:6 Topics: Acetates; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Collagenases; Disease Models, Animal; Disease Progression; Dogs; Enzyme Inhibitors; Metalloproteases; Osteoarthritis, Knee; Pyrroles; Stifle	2006
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit. European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3 Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors	2006
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1 Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima	2007
Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity. Journal of cardiovascular medicine (Hagerstown, Md.), 2006, Volume: 7, Issue:12 Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hemostasis; Humans; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrroles; Rabbits	2006
Arthritis clinical trial results revealed. JAMA, 2007, Jan-03, Volume: 297, Issue:1 Topics: Acetates; Antirheumatic Agents; Arthritis, Rheumatoid; Chondroitin Sulfates; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Osteoarthritis; Piperidines; Pyrimidines; Pyrroles	2007
The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. Annals of the rheumatic diseases, 2008, Volume: 67, Issue:4 Topics: Acetates; Arthritis, Rheumatoid; Cells, Cultured; Chemokines, CXC; Cyclooxygenase Inhibitors; Down-Regulation; Fibroblasts; Humans; Ligands; Lipoxygenase Inhibitors; Polymerase Chain Reaction; Pyrroles; Receptors, CXCR3; RNA, Messenger; Synovial Membrane	2008
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products. British journal of pharmacology, 2007, Volume: 152, Issue:4 Topics: 5-Lipoxygenase-Activating Proteins; Acetates; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arsenites; Bridged Bicyclo Compounds; Calcimycin; Calcium; Carrier Proteins; Cell-Free System; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Molecular Structure; Neutrophils; Nuclear Envelope; Pyrroles; Quinolines; Sodium Compounds; Transfection	2007
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis, 2008, Volume: 29, Issue:2 Topics: Acetates; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Gene Expression Regulation, Neoplastic; Humans; Lipoxygenase Inhibitors; Membrane Potential, Mitochondrial; Mitochondria; Prostaglandin-Endoperoxide Synthases; Pyrroles	2008
In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Acetates; Animals; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cyclopropanes; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Hepatocytes; Humans; Lipoxygenase Inhibitors; Macaca fascicularis; Mice; Mice, Inbred Strains; Microsomes; Paclitaxel; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfides	2008
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors. Prostaglandins, leukotrienes, and essential fatty acids, 2008, Volume: 78, Issue:2 Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blood; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Humans; Indoles; Isoenzymes; Lipoxygenase Inhibitors; Molecular Structure; Neutrophils; Pyrazoles; Pyrroles; Random Allocation; Sulfonamides	2008
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 326, Issue:3 Topics: Adult; Animals; Cattle; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Humans; Intramolecular Oxidoreductases; Microsomes; Prostaglandin-E Synthases; Pyrroles; Sheep	2008
Licofelone attenuates MPTP-induced neuronal toxicity: behavioral, biochemical and cellular evidence. Inflammopharmacology, 2010, Volume: 18, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Behavior, Animal; Caspase 3; Cyclooxygenase Inhibitors; Lipid Peroxidation; Lipoxygenase Inhibitors; Mice; Mitochondria; Motor Activity; MPTP Poisoning; Neuroprotective Agents; NF-kappa B; Nitrites; Oxidative Stress; Pyrroles	2010
Licofelone attenuates quinolinic acid induced Huntington like symptoms: possible behavioral, biochemical and cellular alterations. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Mar-30, Volume: 35, Issue:2 Topics: Animals; Behavior, Animal; Biochemical Phenomena; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Huntington Disease; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mitochondria; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Pyrroles; Quinolinic Acid; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2011
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. European journal of medicinal chemistry, 2011, Volume: 46, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclooxygenase Inhibitors; Edema; Female; Male; Mice; Pyrroles	2011
Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone. British journal of pharmacology, 2011, Volume: 164, Issue:2b Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Body Weight; Caspase 3; Corpus Striatum; Dinoprostone; Huntington Disease; Interleukin-6; Lipid Peroxidation; Lipoxygenase; Male; Mitochondria; Motor Activity; Neuroprotective Agents; NF-kappa B; Nitrites; Nitro Compounds; Propionates; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2011
Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:8 Topics: Adenoma; Animals; Anticarcinogenic Agents; Biological Assay; Biomarkers, Tumor; Disease Models, Animal; Disease Progression; Drug Delivery Systems; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Models, Chemical; Pyrroles	2011
Licofelone-nitric oxide donors as anticancer agents. Archiv der Pharmazie, 2011, Volume: 344, Issue:8 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Nitric Oxide Donors; Pyrroles	2011
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:12 Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Humans; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Pyrroles; Real-Time Polymerase Chain Reaction; RNA, Messenger	2011
The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells. Cancer letters, 2012, Aug-28, Volume: 321, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Membrane; Cell Survival; Colonic Neoplasms; ErbB Receptors; Fluorescent Antibody Technique; Humans; Membrane Fluidity; Mitogen-Activated Protein Kinases; Pyrroles; Signal Transduction	2012
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. Journal of medicinal chemistry, 2012, Mar-22, Volume: 55, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell-Free System; Databases, Factual; Dinoprostone; Humans; Intramolecular Oxidoreductases; Leukotriene B4; Lipoxygenase Inhibitors; Microsomes; Molecular Dynamics Simulation; Prostaglandin-E Synthases; Protein Binding; Protein Conformation; Pyrroles; Recombinant Proteins; Structure-Activity Relationship	2012
Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells. Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:3 Topics: Arachidonate 5-Lipoxygenase; Blotting, Western; Cell Line; Cell Proliferation; Chemokine CCL2; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interferon-gamma; Interleukin-18; Lipoxygenase Inhibitors; Mesangial Cells; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Signal Transduction	2012
The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord. Journal of neurotrauma, 2013, Feb-01, Volume: 30, Issue:3 Topics: Animals; Arachidonate 5-Lipoxygenase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Disease Models, Animal; Drug Resistance; Enzyme Inhibitors; Gene Knockout Techniques; Male; Mice; Mice, Knockout; Neuroprotective Agents; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recovery of Function; Riluzole; Spinal Cord Injuries; Tissue Array Analysis	2013
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice. Pharmacological reports : PR, 2012, Volume: 64, Issue:5 Topics: Animals; Brain; Corpus Striatum; Genes, Immediate-Early; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Minocycline; Morphine; Motor Activity; Pyrroles; Species Specificity	2012
Potential role of licofelone, minocycline and their combination against chronic fatigue stress induced behavioral, biochemical and mitochondrial alterations in mice. Pharmacological reports : PR, 2012, Volume: 64, Issue:5 Topics: Animals; Chronic Disease; Drug Therapy, Combination; Fatigue; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Minocycline; Mitochondria; Motor Activity; Pyrroles; Stress, Psychological	2012
Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-09, Volume: 33, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Leukotriene B4; Locomotion; Metabolomics; Oxidative Stress; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries	2013
Multitargeted low-dose GLAD combination chemoprevention: a novel and promising approach to combat colon carcinogenesis. Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:5 Topics: Adenomatous Polyps; Animals; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Carcinogenesis; Cell Proliferation; Chemoprevention; Colon; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Eflornithine; Female; Gefitinib; Heptanoic Acids; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Pyrroles; Quinazolines	2013
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis. Drug and chemical toxicology, 2014, Volume: 37, Issue:1 Topics: Analysis of Variance; Animals; Apoptosis; Cell Transformation, Neoplastic; DNA Primers; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Flow Cytometry; Fluorouracil; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Time Factors; Trypan Blue; Tumor Cells, Cultured	2014
Cytotoxic and apoptotic functions of licofelone on rat glioma cells. Acta biologica Hungarica, 2013, Volume: 64, Issue:4 Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Drug Screening Assays, Antitumor; Flow Cytometry; Glioma; Pyrroles; Rats	2013
Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice. Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:7 Topics: Animals; Antigens, Polyomavirus Transforming; Blotting, Western; Carcinoma in Situ; Cell Movement; Cell Proliferation; Female; Immunoenzyme Techniques; Lipoxygenase; Male; Mice; Mice, Transgenic; Neoplasm Invasiveness; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder Neoplasms; Uroplakin II	2014
Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2015, Volume: 25 Suppl 1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Disease Models, Animal; Double-Blind Method; Epidural Space; Failed Back Surgery Syndrome; Fibrosis; Gene Expression; Hydroxyproline; Interleukin-6; Laminectomy; Lumbar Vertebrae; Male; Pyrroles; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Tissue Adhesions; Transforming Growth Factor beta1	2015
Effect of licofelone--a dual COX/5-LOX inhibitor in intracerebroventricular streptozotocin-induced behavioral and biochemical abnormalities in rats. Journal of molecular neuroscience : MN, 2015, Volume: 55, Issue:3 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Cyclooxygenase Inhibitors; Cytokines; Glutathione; Lipoxygenase Inhibitors; Male; Malondialdehyde; Maze Learning; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Streptozocin	2015
Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair. The American journal of sports medicine, 2014, Volume: 42, Issue:12 Topics: Acetyl-CoA C-Acetyltransferase; Animals; Apoptosis Regulatory Proteins; Autophagy-Related Protein 5; Beclin-1; Biomechanical Phenomena; Carrier Proteins; Diacylglycerol O-Acyltransferase; Enzyme Inhibitors; Fibrocartilage; Fibrosis; Hydroxyproline; Interleukin-10; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Male; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Proteins; Muscle, Skeletal; Perilipin-1; Phosphoproteins; PPAR gamma; Proteins; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Rotator Cuff; Vesicular Transport Proteins; Wound Healing	2014
Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke. Current cancer drug targets, 2015, Volume: 15, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Body Weight; Celecoxib; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors; Female; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Precancerous Conditions; Pyrroles; Smoking; Survival Rate; Toxicity Tests, Subchronic	2015
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. Oncotarget, 2015, Jun-20, Volume: 6, Issue:17 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arachidonic Acid; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Cell Proliferation; Ceruletide; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Doublecortin-Like Kinases; Lipoxygenase Inhibitors; Mice; Mice, Knockout; MicroRNAs; Neoplastic Stem Cells; Pancreatic Neoplasms; Pancreatitis; Protein Serine-Threonine Kinases; Pyrroles	2015
A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice. Neurochemical research, 2015, Volume: 40, Issue:9 Topics: Animals; Anticonvulsants; Arginine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Lipoxygenase Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pyrroles	2015
Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma. Oncotarget, 2015, Oct-20, Volume: 6, Issue:32 Topics: Animals; Antineoplastic Agents; Arachidonate 5-Lipoxygenase; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Synergism; ErbB Receptors; Female; Gefitinib; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Pyrroles; Quinazolines; Signal Transduction	2015
Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males. The Journal of clinical investigation, 2017, Aug-01, Volume: 127, Issue:8 Topics: 5-Lipoxygenase-Activating Proteins; Androgens; Animals; Arachidonate 5-Lipoxygenase; Dihydrotestosterone; Female; Humans; Hydroxyurea; Leukocytes; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Pyrroles; Rats; Rats, Wistar; Sex Factors; Sulindac; Testosterone	2017
Novel drug delivery of dual acting prodrugs of hydroxychloroquine with aryl acetic acid NSAIDs: Design, kinetics and pharmacological study. Drug delivery and translational research, 2017, Volume: 7, Issue:5 Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Diclofenac; Drug Design; Female; Freund's Adjuvant; Hydroxychloroquine; Inflammation; Male; Mice; Prodrugs; Pyrroles; Rats; Rats, Wistar	2017
Licofelone Attenuates LPS-induced Depressive-like Behavior in Mice: A Possible Role for Nitric Oxide. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2018, Volume: 21, Issue:1 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Injections, Intraperitoneal; Lipopolysaccharides; Male; Mice; Nitric Oxide; Pyrroles	2018
Licofelone-DPPC Interactions: Putting Membrane Lipids on the Radar of Drug Development. Molecules (Basel, Switzerland), 2019, Jan-31, Volume: 24, Issue:3 Topics: 1,2-Dipalmitoylphosphatidylcholine; Drug Development; Membrane Lipids; Microscopy; Molecular Structure; Pyrroles; Spectrum Analysis; Temperature	2019
Synthesis and highly potent anti-inflammatory activity of licofelone- and ketorolac-based 1-arylpyrrolizin-3-ones. Bioorganic & medicinal chemistry, 2019, 10-15, Volume: 27, Issue:20 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Edema; Ketorolac; Lipopolysaccharides; Macrophages; Male; Mice; Molecular Docking Simulation; Molecular Structure; Nitric Oxide; Pyrroles; Structure-Activity Relationship; Tetradecanoylphorbol Acetate	2019
Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor. Carcinogenesis, 2020, 03-13, Volume: 41, Issue:1 Topics: Animals; Anticarcinogenic Agents; Arachidonate 5-Lipoxygenase; Carcinogenesis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; DNA Adducts; DNA Damage; Drug Administration Schedule; Female; Humans; Inflammation; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; MicroRNAs; Pyrroles; Time Factors; Tobacco Smoke Pollution; Toxicity Tests, Subchronic	2020
Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, reverses endotoxin-induced impaired atrial chronotropic responsiveness to cholinergic stimulation in rats. European journal of pharmacology, 2020, Nov-15, Volume: 887 Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Carbachol; Cholinergic Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endotoxins; Heart Atria; Heart Rate; Hydrocortisone; Indomethacin; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Parasympathetic Nervous System; Pyrroles; Rats; Rats, Wistar	2020
Evaluation of licofelone as an adjunct anti-inflammatory therapy to biologic scaffolds in the treatment of volumetric muscle loss. Cell and tissue research, 2021, Volume: 385, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tissue Scaffolds	2021