Page last updated: 2024-08-18

pyrroles and mk 2206

pyrroles has been researched along with mk 2206 in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	10 (76.92)	24.3611
2020's	3 (23.08)	2.80

Authors

Authors	Studies
Cao, Y; Chen, JZ; Chen, SF; Han, S	1
Cheng, AL; Hsu, C; Lee, BS; Liao, SC; Lin, LI; Liou, JY; Ou, DL	1
Martinho, O; Reis, RM; Zucca, LE	1
Crafter, C; D'Cruz, CM; Davies, BR; Dudley, P; Guan, N; Hanson, L; Jacobs, V; Jacques, K; James, N; Jenkins, EL; Kodaira, M; Ladd, B; Lindemann, J; Logie, A; Tamura, K; Zinda, M	1
Cheon, JH; Choi, AR; Kim, HS; Kim, JH; Woo, YH; Yoon, S	1
Haniuda, M; Hosokawa, Y; Hyodo, T; Karnan, S; Konishi, H; Ota, A; Tsuzuki, S; Wahiduzzaman, M; Yamaji, M	1
Brunton, VG; Byron, A; Derksen, PWB; Gómez-Cuadrado, L; Mandoli, A; Martens, JH; Rätze, M; Renes, J; Singh, AA; Strengman, E; Stunnenberg, HG; Tenhagen, M; Teo, K; van Amersfoort, M; van Diest, PJ	1
Chen, Y; Deng, J; Duan, Z; Evers, BM; Ghaffari, S; Guo, W; He, Y; Lin, PC; Lin, Y; Liu, J; Liu, S; Shi, J; Stewart, RL; Tai, F; Wang, C; Wang, Y; Wu, Y; Zeng, L; Zhang, Q; Zhou, BP; Zhou, MM	1
Guo, Z; He, J; Huang, C; Huang, H; Jiang, L; Liao, Y; Liu, J; Liu, Y; Wang, X; Xia, X	1
Bjune, K; Naderi, S; Wierød, L	1
Bowen, JP; Güner, OF; Matesic, DF; Uko, NE	1
Decaens, T; Lerat, H; Macek Jílková, Z; Marche, PN; Mroweh, M; Roth, G	1
Chow, Z; Evers, BM; Johnson, J; Lee, E; Rychahou, P; Weiss, HL	1

Reviews

2 review(s) available for pyrroles and mk 2206

Article	Year
Akt Pathway Inhibitors. Current topics in medicinal chemistry, 2020, Volume: 20, Issue:10 Topics: Antineoplastic Agents; Benzylamines; Cell Line, Tumor; Diamines; Drug Design; Heterocyclic Compounds, 3-Ring; Humans; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Phospholipids; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Thiophenes	2020
Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment. International journal of molecular sciences, 2021, Feb-11, Volume: 22, Issue:4 Topics: Aminopyridines; Carcinoma, Hepatocellular; Drug Delivery Systems; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Liver Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Tumor Microenvironment	2021

Article

Year

Akt Pathway Inhibitors.

Current topics in medicinal chemistry, 2020, Volume: 20, Issue:10

Topics: Antineoplastic Agents; Benzylamines; Cell Line, Tumor; Diamines; Drug Design; Heterocyclic Compounds, 3-Ring; Humans; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Phospholipids; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Thiophenes

2020

Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment.

International journal of molecular sciences, 2021, Feb-11, Volume: 22, Issue:4

Topics: Aminopyridines; Carcinoma, Hepatocellular; Drug Delivery Systems; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Liver Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Tumor Microenvironment

2021

Trials

1 trial(s) available for pyrroles and mk 2206

Article	Year
Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors. Molecular cancer therapeutics, 2015, Volume: 14, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Doxycycline; Female; Heterocyclic Compounds, 3-Ring; Humans; Male; Mice, Nude; Mutation, Missense; Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction; Xenograft Model Antitumor Assays	2015

Article

Year

Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.

Molecular cancer therapeutics, 2015, Volume: 14, Issue:11

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Doxycycline; Female; Heterocyclic Compounds, 3-Ring; Humans; Male; Mice, Nude; Mutation, Missense; Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction; Xenograft Model Antitumor Assays

2015

Other Studies

10 other study(ies) available for pyrroles and mk 2206

Article	Year
Insight into the structural mechanism for PKBα allosteric inhibition by molecular dynamics simulations and free energy calculations. Journal of molecular graphics & modelling, 2014, Volume: 48 Topics: Allosteric Regulation; Allosteric Site; Catalytic Domain; Heterocyclic Compounds, 3-Ring; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Secondary; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Thermodynamics	2014
Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin. Molecular cancer, 2014, Jan-03, Volume: 13 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Synergism; Enzyme Inhibitors; Everolimus; Flow Cytometry; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Male; Mice, Inbred BALB C; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Quinolines; Receptors, Somatomedin; Signal Transduction; Sirolimus; Survivin; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2014
AXL as a modulator of sunitinib response in glioblastoma cell lines. Experimental cell research, 2015, Mar-01, Volume: 332, Issue:1 Topics: Angiogenesis Inhibitors; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; ErbB Receptors; Gene Knockdown Techniques; Glioblastoma; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sunitinib	2015
Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363-induced Increase in the Level of Phosphorylated AKT. Anticancer research, 2016, Volume: 36, Issue:11 Topics: Breast Neoplasms; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Humans; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles	2016
Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer medicine, 2017, Volume: 6, Issue:11 Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inhibitory Concentration 50; Mesothelioma; Oxadiazoles; Phosphorylation; Phosphorylcholine; Pleural Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinoxalines; Sulfonamides; Thiadiazoles; Thiophenes	2017
E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer. Scientific reports, 2018, 10-18, Volume: 8, Issue:1 Topics: Animals; Autocrine Communication; Breast Neoplasms; Cadherins; Carcinoma, Lobular; Class I Phosphatidylinositol 3-Kinases; Female; Heterocyclic Compounds, 3-Ring; Humans; MCF-7 Cells; Mice; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrimidines; Pyrroles; Signal Transduction	2018
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer. Nature communications, 2018, 12-05, Volume: 9, Issue:1 Topics: Acetylation; Animals; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cyclin-Dependent Kinase 6; Female; Forkhead Box Protein O3; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Humans; Mice; Mice, Nude; Nuclear Proteins; Oxadiazoles; Promoter Regions, Genetic; Protein Binding; Protein Domains; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Sirtuins; Transcription Factors	2018
Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide. Journal of experimental & clinical cancer research : CR, 2019, May-24, Volume: 38, Issue:1 Topics: Animals; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; MCF-7 Cells; Mice; Nitriles; Phenylthiohydantoin; Pyrroles; Pyrrolidines; Signal Transduction; Ubiquitin Thiolesterase; Xenograft Model Antitumor Assays	2019
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms. PloS one, 2019, Volume: 14, Issue:6 Topics: Aminopyridines; Animals; Benzimidazoles; CHO Cells; Cricetinae; Cricetulus; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Phosphorylcholine; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptors, LDL; Ribonucleosides; RNA Stability; RNA, Messenger; Transcriptional Activation	2019
Role of AMPK and Akt in triple negative breast cancer lung colonization. Neoplasia (New York, N.Y.), 2021, Volume: 23, Issue:4 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line, Tumor; Energy Metabolism; Female; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplastic Cells, Circulating; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; RNA Interference; RNA, Small Interfering; Signal Transduction; Triple Negative Breast Neoplasms	2021