pyrroles has been researched along with lcl161 in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, KF; Chen, PJ; Cheng, AL; Lin, JP; Liu, CY; Shiau, CW; Tai, WT; Yu, HC | 1 |
| Gupte, A; Hawkins, CJ; Miles, MA; Shekhar, TM; Tascone, B; Taylor, S; Walkley, CR | 1 |
| Bi, L; Gomez, M; Haug, J; Kimlinger, T; Kumar, S; Mukhopadhyay, B; Painuly, U; Prasad, V; Rajkumar, SV; Ramakrishnan, V | 1 |
| Burvenich, IJG; Harris, MA; Hawkins, CJ; Parker, BS; Rigopoulos, A; Scott, AM; Shekhar, TM; Spurling, A; Walkley, CR; Zanker, D | 1 |
4 other study(ies) available for pyrroles and lcl161
| Article | Year |
|---|---|
Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Biomimetic Materials; Carcinoma, Hepatocellular; Down-Regulation; HEK293 Cells; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thiazoles; Treatment Outcome; Xenograft Model Antitumor Assays | 2012 |
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Baculoviral IAP Repeat-Containing 3 Protein; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Cyclohexanes; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; HEK293 Cells; Humans; Inhibitor of Apoptosis Proteins; Mice, Knockout; Osteosarcoma; Phenotype; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2016 |
Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Multiple Myeloma; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thiazoles; Unfolded Protein Response; Up-Regulation; X-Box Binding Protein 1 | 2016 |
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Mice; Neoplasms; Positron-Emission Tomography; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2019 |