pyrroles has been researched along with lb42708 in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, HH; Gang, J; Kim, HS; Kim, JW; Koh, JS; Koh, SS; Song, SY; Wen, J | 1 |
| Choi, YK; Ha, KS; Kim, CK; Kim, YM; Kwon, YG; Lee, H; Won, MH | 1 |
| Cho, YC; Jang, BC; Jang, JH; Kim, DE; Kim, KH; Kim, S; Kwon, TK; Lee, J; Lee, KS; Park, JS; Park, JW | 1 |
3 other study(ies) available for pyrroles and lb42708
| Article | Year |
|---|---|
The farnesyltransferase inhibitor, LB42708, inhibits growth and induces apoptosis irreversibly in H-ras and K-ras-transformed rat intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Imidazoles; Intestinal Mucosa; Piperazines; Pyrroles; Rats; rhoB GTP-Binding Protein | 2006 |
The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signal pathways.
Topics: Base Sequence; Cell Line; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrroles; ras Proteins; RNA, Small Interfering; Signal Transduction; Vascular Endothelial Growth Factor A | 2010 |
BAI, a novel Cdk inhibitor, enhances farnesyltransferase inhibitor LB42708-mediated apoptosis in renal carcinoma cells through the downregulation of Bcl-2 and c-FLIP (L).
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indazoles; Kidney Neoplasms; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thiazolidines | 2014 |