pyrroles has been researched along with gdc-0152 in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Budha, N; Buonarati, MH; Dean, B; Hop, CE; Jones, SA; Murakami, SC; Shin, YG; Ware, J; Wong, H | 1 |
| Blackwood, E; Budha, NR; Chan, IT; Darbonne, WC; Eckhardt, SG; Erickson, R; Fairbrother, WJ; Flygare, JA; Gould, SE; Hop, CE; LoRusso, P; Mamounas, M; Steigerwalt, R; Wagner, A; Ware, JA; West, K; Wong, H; Yu, R | 1 |
| Amemiya, K; Blackwood, E; Cain, G; Dambach, D; Diaz, D; Dybdal, N; Erickson, RI; Fairbrother, WJ; Flygare, JA; Lewin-Koh, SC; Mamounas, M; Steigerwalt, R; Tarrant, J; West, K; Wong, H | 1 |
| Budha, N; Hop, CE; Khojasteh, SC; Lyssikatos, J; Mulder, T; Rudewicz, PJ; Solon, E; Ware, JA; Wong, H; Yue, Q | 1 |
| Hu, R; Li, J; Liu, Z; Miao, M; Yao, K | 1 |
| Fan, C; Gu, W; Liang, Y; Shu, T; Song, X; Wang, C; Wang, W; Yang, L | 1 |
| Carosati, E; Cruciani, G; Gabbert, HE; Mahotka, C; Mannhold, R; Randazzo, GM; Reif, M; Stanitzki, B; Stevens, J; van den Höfel, N | 1 |
| Gupte, A; Hawkins, CJ; Miles, MA; Shekhar, TM; Tascone, B; Taylor, S; Walkley, CR | 1 |
| Baeza-Kallee, N; Colin, C; Denicolaï, E; El-Battari, A; Figarella-Branger, D; Jiguet-Jiglaire, C; Soubéran, A; Tabouret, E; Tchoghandjian, A; Villard, C | 1 |
| Hongming, D; Miao, M; Peiqi, L; Rong, H; Wei, J; Zhuogang, L | 1 |
| Hawkins, CJ; Miles, MA | 1 |
| Chakravarty, P; Devanaboyina, U; Fairbrother, WJ; Fernandez, GE; Flygare, JA; Ganem, G; La, H; Mantik, P; Narang, AS; Russell, D; Shih, D; Steigerwalt, RW; Wong, H; Xie, M | 1 |
| Baeza-Kallee, N; Cappaï, J; Chocry, M; Colin, C; Figarella-Branger, D; Kovacic, H; Lafitte, D; Nuccio, C; Quillien, V; Raujol, J; Rougon, G; Soubéran, A; Tchoghandjian, A | 1 |
| Burvenich, IJG; Harris, MA; Hawkins, CJ; Parker, BS; Rigopoulos, A; Scott, AM; Shekhar, TM; Spurling, A; Walkley, CR; Zanker, D | 1 |
| Hu, R; Jiang, W; Li, C; Liang, PQ; Liu, ZG | 1 |
1 trial(s) available for pyrroles and gdc-0152
| Article | Year |
|---|---|
Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction.
Topics: Chromatography, Liquid; Cyclohexanes; Dose-Response Relationship, Drug; Drug Stability; Humans; Linear Models; Neoplasms; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2013 |
14 other study(ies) available for pyrroles and gdc-0152
| Article | Year |
|---|---|
Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis.
Topics: Animals; Area Under Curve; Caspase Inhibitors; Cyclohexanes; Cytokines; Dogs; Drug Evaluation, Preclinical; Female; Half-Life; Humans; Inhibitor of Apoptosis Proteins; Injections, Intravenous; Male; Models, Biological; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity | 2012 |
Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.
Topics: Animals; Antineoplastic Agents; Chemokines; Cyclohexanes; Dogs; Female; Inhibitor of Apoptosis Proteins; Liver; Lung; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity; Systemic Inflammatory Response Syndrome; Toxicity Tests; Tumor Necrosis Factor-alpha | 2013 |
Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: a novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazole.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Autoradiography; Bile; Biotransformation; Carbon Radioisotopes; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Feces; Female; Half-Life; Hepatocytes; Hippurates; Hydrolysis; Injections, Intravenous; Isotope Labeling; Male; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Oxidation-Reduction; Pyrroles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Tissue Distribution; Triazoles | 2013 |
GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K/Akt signaling pathway.
Topics: Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Caspase 9; Cell Proliferation; Cyclohexanes; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein | 2015 |
GDC-0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway.
Topics: Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Angiopoietins; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Humans; MAP Kinase Signaling System; Osteosarcoma; Pyrroles; Recombinant Proteins; Up-Regulation | 2015 |
Discovery of Novel, Potent, and Specific Cell-Death Inducers in the Jurkat Acute Lymphoblastic Leukemia Cell Line.
Topics: Antineoplastic Agents; Azocines; Benzhydryl Compounds; Cell Death; Cell Proliferation; Cyclohexanes; Dipeptides; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Indoles; Jurkat Cells; Ligands; Molecular Structure; Pyrroles; Structure-Activity Relationship | 2015 |
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Baculoviral IAP Repeat-Containing 3 Protein; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Cyclohexanes; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; HEK293 Cells; Humans; Inhibitor of Apoptosis Proteins; Mice, Knockout; Osteosarcoma; Phenotype; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2016 |
Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromatography; Cyclohexanes; Glioblastoma; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Paraffin Embedding; Prognosis; Pyrroles; Tissue Fixation; Young Adult | 2016 |
GDC-0152-induced autophagy promotes apoptosis in HL-60 cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; Autophagy-Related Proteins; Beclin-1; Caspase Inhibitors; Cyclohexanes; Down-Regulation; HL-60 Cells; Humans; Macrolides; Membrane Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species | 2018 |
Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways.
Topics: Apoptosis Regulatory Proteins; Biomimetic Materials; Cell Line, Tumor; Cyclohexanes; DNA Damage; DNA End-Joining Repair; Drug Delivery Systems; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Mutagenesis; Neoplasm Proteins; Neoplasms; Pyrroles | 2018 |
Cyclodextrin Reduces Intravenous Toxicity of a Model Compound.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cyclohexanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Excipients; Hemolysis; Injections, Intravenous; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Models, Animal; Pyrroles; Rats; Solubility; Toxicity Tests, Acute | 2019 |
Inhibitor of Apoptosis Proteins Determines Glioblastoma Stem-Like Cell Fate in an Oxygen-Dependent Manner.
Topics: Adaptor Proteins, Signal Transducing; Adrenomedullin; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Brain Neoplasms; Carbonic Anhydrase IX; Cell Differentiation; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Neoplasm Proteins; Neoplastic Stem Cells; Oxygen; Pyrroles; Signal Transduction; Spheroids, Cellular; Tissue Culture Techniques; X-Linked Inhibitor of Apoptosis Protein | 2019 |
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Mice; Neoplasms; Positron-Emission Tomography; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2019 |
[Role of Reactive Oxygen Species in GDC-0152-Induced Apoptosis and Autophagy of NB4 cells].
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cyclohexanes; Humans; Leukemia, Promyelocytic, Acute; Pyrroles; Reactive Oxygen Species | 2019 |