Page last updated: 2024-08-18

pyrroles and dc 88-a

pyrroles has been researched along with dc 88-a in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's4 (23.53)18.2507
2000's11 (64.71)29.6817
2010's1 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ichimura, M; Katsumata, S; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K1
Ichimura, M; Iida, T; Muroi, K; Sano, H; Takahashi, K; Yasuzawa, T1
Ichimura, M; Mihara, A; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K1
Boger, DL; Nishi, T1
Amishiro, N; Gomi, K; Kobayashi, E; Nagamura, S; Okamoto, A; Saito, H1
Amishiro, N; Gomi, K; Kobayashi, E; Nagamura, S; Okabe, M; Okamoto, A; Saito, H1
Boger, DL; Hedrick, MP; Hughes, TV1
Boger, DL; Hedrick, MP; Stauffer, F1
Boger, DL; Brunette, SR; Garbaccio, RM1
Boger, DL; Fink, BE; Hedrick, MP; Schmitt, HW1
Searcey, M1
Fukuyama, T; Kurokawa, T; Tokuyama, H; Yamada, K1
Boger, DL; Hedrick, MP; Hwang, I; Kastrinsky, DB; Parrish, JP; Stauffer, F1
Bando, T; Fukuda, N; Iida, H; Narita, A; Sugiyama, H; Tao, ZF; Yamori, T1
Boger, DL; Ham, YW1
Howard, T; Lee, M; Lingerfelt, B; McNulty, L; Pati, H; Townes, H1
Jackson, PJM; Rahman, KM; Thurston, DE1

Reviews

1 review(s) available for pyrroles and dc 88-a

ArticleYear
Duocarmycins--natures prodrugs?
    Current pharmaceutical design, 2002, Volume: 8, Issue:15

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; DNA; Drug Stability; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Prodrugs; Pyrroles; Pyrrolidinones; Structure-Activity Relationship; Tumor Cells, Cultured

2002

Other Studies

16 other study(ies) available for pyrroles and dc 88-a

ArticleYear
Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production.
    The Journal of antibiotics, 1991, Volume: 44, Issue:10

    Topics: Antibiotics, Antineoplastic; Bromine; Carbon; Chlorine; Chromatography, High Pressure Liquid; Duocarmycins; Fermentation; Humans; Hydrogen-Ion Concentration; Indoles; Kinetics; Metals; Microscopy, Electron, Scanning; Nitrogen; Pyrroles; Pyrrolidinones; Streptomyces

1991
Structures of duocarmycins, novel antitumor antibiotics produced by Streptomyces sp.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:9

    Topics: Antibiotics, Antineoplastic; Duocarmycins; Indoles; Molecular Conformation; Pyrroles; Pyrrolidinones; Streptomyces

1988
Interconversion and stability of duocarmycins, a new family of antitumor antibiotics: correlation to their cytotoxic and antimicrobial activities in vitro.
    Oncology research, 1993, Volume: 5, Issue:4-5

    Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed; Drug Stability; Duocarmycins; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Pyrroles; Pyrrolidinones; Temperature

1993
Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: development of a divergent strategy for the total synthesis of duocarmycins A and SA.
    Bioorganic & medicinal chemistry, 1995, Volume: 3, Issue:1

    Topics: Antibiotics, Antineoplastic; Carbon; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Pyrrolidinones

1995
Synthesis and antitumor activity of duocarmycin derivatives: a-ring pyrrole compounds bearing 5-membered heteroarylacryloyl groups.
    Chemical & pharmaceutical bulletin, 1999, Volume: 47, Issue:10

    Topics: Acrylates; Animals; Antineoplastic Agents; Blood Cells; Combinatorial Chemistry Techniques; DNA; Duocarmycins; HeLa Cells; Humans; Indoles; Mice; Models, Chemical; Pyrroles; Pyrrolidinones; Sarcoma 180; Structure-Activity Relationship

1999
Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole compounds bearing beta-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Duocarmycins; HeLa Cells; Humans; Indoles; Inhibitory Concentration 50; Leukocyte Count; Male; Mice; Neoplasms, Experimental; Platelet Count; Pyrroles; Pyrrolidinones; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
    The Journal of organic chemistry, 2001, Apr-06, Volume: 66, Issue:7

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Crystallography, X-Ray; DNA; Duocarmycins; Indoles; Inhibitory Concentration 50; Kinetics; Leucomycins; Leukemia L1210; Mice; Pyrroles; Pyrrolidinones

2001
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Bioorganic & medicinal chemistry letters, 2001, Aug-06, Volume: 11, Issue:15

    Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured

2001
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
    The Journal of organic chemistry, 2001, Jul-27, Volume: 66, Issue:15

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Duocarmycins; Humans; Indoles; Leucomycins; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrroles; Pyrrolidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet

2001
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
    The Journal of organic chemistry, 2001, Oct-05, Volume: 66, Issue:20

    Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Binding Sites; Combinatorial Chemistry Techniques; Cyclopropanes; DNA; DNA, Viral; Duocarmycins; Indoles; Inhibitory Concentration 50; Leucomycins; Pyrroles; Pyrrolidinones; Simian virus 40; Structure-Activity Relationship

2001
Total synthesis of the duocarmycins.
    Journal of the American Chemical Society, 2003, Jun-04, Volume: 125, Issue:22

    Topics: Antibiotics, Antineoplastic; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones; Stereoisomerism; Streptomyces

2003
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Bioorganic & medicinal chemistry, 2003, Aug-15, Volume: 11, Issue:17

    Topics: Alkylation; Amides; DNA; Duocarmycins; Indoles; Kinetics; Models, Molecular; Pyrroles; Pyrrolidinones; Sulfones

2003
Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides.
    Chemistry & biology, 2003, Volume: 10, Issue:8

    Topics: Alkylation; Antineoplastic Agents, Alkylating; Base Sequence; Cell Line, Tumor; Diamide; DNA; Drug Screening Assays, Antitumor; Duocarmycins; Gene Expression Profiling; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Molecular Sequence Data; Molecular Structure; Oligonucleotide Array Sequence Analysis; Pyrroles; Pyrrolidinones

2003
A powerful selection assay for mixture libraries of DNA alkylating agents.
    Journal of the American Chemical Society, 2004, Aug-04, Volume: 126, Issue:30

    Topics: Alkylating Agents; Alkylation; Binding, Competitive; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; DNA; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones

2004
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
    Molecules (Basel, Switzerland), 2004, Feb-28, Volume: 9, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Cyclization; Cyclopropanes; Duocarmycins; Humans; Indoles; Pyrroles; Pyrrolidinones

2004
The use of molecular dynamics simulations to evaluate the DNA sequence-selectivity of G-A cross-linking PBD-duocarmycin dimers.
    Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1

    Topics: Base Sequence; Benzodiazepines; Cell Line, Tumor; Cell Survival; Cross-Linking Reagents; Dimerization; DNA; Dose-Response Relationship, Drug; Duocarmycins; Humans; Indoles; Ligands; Molecular Dynamics Simulation; Molecular Structure; Pyrroles; Pyrrolidinones; Structure-Activity Relationship

2017