Page last updated: 2024-08-18

pyrroles and cs 0777

pyrroles has been researched along with cs 0777 in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	7 (87.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carrothers, TJ; Inaba, S; Moberly, JB; Rohatagi, S; Shimozato, T; Truitt, KE; Zahir, H	1
Hsu, C; Moberly, JB; Noveck, RJ; Rohatagi, S; Truitt, KE; Zahir, H	1
Honda, T; Inaba, S; Kubota, K; Matsuoka, T; Nara, F; Tamura, M; Watanabe, N; Yahara, C; Yonesu, K	1
Chen, S; Ford, DM; Moberly, JB; Mochizuki, T; Truitt, KE; Vollmer, TL; Zahir, H	1
Inaba, S; Kubota, K; Sakurai, H; Shinagawa, A; Takanaka, K	1
Goto, M; Ikeda, T; Inaba, S; Iwabuchi, H; Izumi, T; Takahashi, M; Tanaka, H	1
Doi-Komuro, H; Goto, M; Inaba, SI; Inoue, R; Izumi, T; Kagari, T; Oshima, K; Shimozato, T; Tanaka, H; Tanaka-Takanaka, K; Tomisato, W; Yuita, H	1
Inaba, SI; Izumi, T; Kubota, K; Sakurai, H; Tanaka-Takanaka, K; Yamaguchi-Goto, M; Yonesu, K	1

Trials

2 trial(s) available for pyrroles and cs 0777

Article	Year
Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator. Journal of clinical pharmacology, 2009, Volume: 49, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Amino Alcohols; CD4-Positive T-Lymphocytes; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lymphocyte Count; Lymphocyte Subsets; Lymphocytes; Lysophospholipids; Male; Middle Aged; Models, Biological; Prodrugs; Pyrroles; Receptors, Lysosphingolipid; Sphingosine; Young Adult	2009
Pharmacological modulation of peripheral T and B lymphocytes by a selective sphingosine 1-phosphate receptor-1 modulator. Journal of clinical pharmacology, 2012, Volume: 52, Issue:7 Topics: Adult; Amino Alcohols; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lymphocyte Count; Male; Pyrroles; Receptors, Lysosphingolipid; Young Adult	2012

Article

Year

Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator.

Journal of clinical pharmacology, 2009, Volume: 49, Issue:1

Topics: Administration, Oral; Adolescent; Adult; Amino Alcohols; CD4-Positive T-Lymphocytes; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lymphocyte Count; Lymphocyte Subsets; Lymphocytes; Lysophospholipids; Male; Middle Aged; Models, Biological; Prodrugs; Pyrroles; Receptors, Lysosphingolipid; Sphingosine; Young Adult

2009

Pharmacological modulation of peripheral T and B lymphocytes by a selective sphingosine 1-phosphate receptor-1 modulator.

Journal of clinical pharmacology, 2012, Volume: 52, Issue:7

Topics: Adult; Amino Alcohols; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lymphocyte Count; Male; Pyrroles; Receptors, Lysosphingolipid; Young Adult

2012

Other Studies

6 other study(ies) available for pyrroles and cs 0777

Article	Year
Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes. The Journal of biological chemistry, 2011, Jul-15, Volume: 286, Issue:28 Topics: Amino Alcohols; Animals; Enzyme Inhibitors; Erythrocytes; Fructose; HEK293 Cells; Humans; Morpholines; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Pyrroles; Rats; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors	2011
Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. Journal of neuroimmunology, 2012, May-15, Volume: 246, Issue:1-2 Topics: Administration, Oral; Amino Alcohols; CD4-Positive T-Lymphocytes; Dose-Response Relationship, Immunologic; Down-Regulation; Humans; Lymphocyte Subsets; Lymphopenia; Lysophospholipids; Multiple Sclerosis; Pilot Projects; Pyrroles; Receptors, Lysosphingolipid; Sphingosine	2012
Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling. Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:8 Topics: Alkaline Phosphatase; Amino Alcohols; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Isoenzymes; Kidney; Propylene Glycols; Proteomics; Pyrroles; Sphingosine	2013
Pharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys. Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:12 Topics: Administration, Oral; Algorithms; Amino Alcohols; Animals; Biotransformation; Feces; Hydroxylation; Injections, Intravenous; Intestinal Absorption; Macaca fascicularis; Male; Oxidation-Reduction; Phosphorylation; Protein Binding; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Tissue Distribution	2015
Evaluation of species difference in peripheral lymphocyte reduction effect of CS-0777, a sphingosine 1-phosphate receptor modulator, based on a pharmacokinetic/pharmacodynamic model analysis. Biopharmaceutics & drug disposition, 2016, Volume: 37, Issue:9 Topics: Administration, Oral; Amino Alcohols; Animals; Dose-Response Relationship, Drug; Female; Lymphocytes; Macaca fascicularis; Male; Pyrroles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Lysosphingolipid; Species Specificity	2016
Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans. Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:3 Topics: Alkaline Phosphatase; Amino Alcohols; Enzyme Inhibitors; Erythrocytes; Female; Fructose; Humans; Intestine, Small; Kidney; Kinetics; Levamisole; Male; Microsomes, Liver; Morpholines; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyrroles; Receptors, Lysosphingolipid; Recombinant Proteins	2018