Page last updated: 2024-08-18

pyrroles and cs 0777

pyrroles has been researched along with cs 0777 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's7 (87.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carrothers, TJ; Inaba, S; Moberly, JB; Rohatagi, S; Shimozato, T; Truitt, KE; Zahir, H1
Hsu, C; Moberly, JB; Noveck, RJ; Rohatagi, S; Truitt, KE; Zahir, H1
Honda, T; Inaba, S; Kubota, K; Matsuoka, T; Nara, F; Tamura, M; Watanabe, N; Yahara, C; Yonesu, K1
Chen, S; Ford, DM; Moberly, JB; Mochizuki, T; Truitt, KE; Vollmer, TL; Zahir, H1
Inaba, S; Kubota, K; Sakurai, H; Shinagawa, A; Takanaka, K1
Goto, M; Ikeda, T; Inaba, S; Iwabuchi, H; Izumi, T; Takahashi, M; Tanaka, H1
Doi-Komuro, H; Goto, M; Inaba, SI; Inoue, R; Izumi, T; Kagari, T; Oshima, K; Shimozato, T; Tanaka, H; Tanaka-Takanaka, K; Tomisato, W; Yuita, H1
Inaba, SI; Izumi, T; Kubota, K; Sakurai, H; Tanaka-Takanaka, K; Yamaguchi-Goto, M; Yonesu, K1

Trials

2 trial(s) available for pyrroles and cs 0777

ArticleYear
Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator.
    Journal of clinical pharmacology, 2009, Volume: 49, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Amino Alcohols; CD4-Positive T-Lymphocytes; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lymphocyte Count; Lymphocyte Subsets; Lymphocytes; Lysophospholipids; Male; Middle Aged; Models, Biological; Prodrugs; Pyrroles; Receptors, Lysosphingolipid; Sphingosine; Young Adult

2009
Pharmacological modulation of peripheral T and B lymphocytes by a selective sphingosine 1-phosphate receptor-1 modulator.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:7

    Topics: Adult; Amino Alcohols; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lymphocyte Count; Male; Pyrroles; Receptors, Lysosphingolipid; Young Adult

2012

Other Studies

6 other study(ies) available for pyrroles and cs 0777

ArticleYear
Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes.
    The Journal of biological chemistry, 2011, Jul-15, Volume: 286, Issue:28

    Topics: Amino Alcohols; Animals; Enzyme Inhibitors; Erythrocytes; Fructose; HEK293 Cells; Humans; Morpholines; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Pyrroles; Rats; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors

2011
Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients.
    Journal of neuroimmunology, 2012, May-15, Volume: 246, Issue:1-2

    Topics: Administration, Oral; Amino Alcohols; CD4-Positive T-Lymphocytes; Dose-Response Relationship, Immunologic; Down-Regulation; Humans; Lymphocyte Subsets; Lymphopenia; Lysophospholipids; Multiple Sclerosis; Pilot Projects; Pyrroles; Receptors, Lysosphingolipid; Sphingosine

2012
Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling.
    Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:8

    Topics: Alkaline Phosphatase; Amino Alcohols; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Isoenzymes; Kidney; Propylene Glycols; Proteomics; Pyrroles; Sphingosine

2013
Pharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:12

    Topics: Administration, Oral; Algorithms; Amino Alcohols; Animals; Biotransformation; Feces; Hydroxylation; Injections, Intravenous; Intestinal Absorption; Macaca fascicularis; Male; Oxidation-Reduction; Phosphorylation; Protein Binding; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Tissue Distribution

2015
Evaluation of species difference in peripheral lymphocyte reduction effect of CS-0777, a sphingosine 1-phosphate receptor modulator, based on a pharmacokinetic/pharmacodynamic model analysis.
    Biopharmaceutics & drug disposition, 2016, Volume: 37, Issue:9

    Topics: Administration, Oral; Amino Alcohols; Animals; Dose-Response Relationship, Drug; Female; Lymphocytes; Macaca fascicularis; Male; Pyrroles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Lysosphingolipid; Species Specificity

2016
Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:3

    Topics: Alkaline Phosphatase; Amino Alcohols; Enzyme Inhibitors; Erythrocytes; Female; Fructose; Humans; Intestine, Small; Kidney; Kinetics; Levamisole; Male; Microsomes, Liver; Morpholines; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyrroles; Receptors, Lysosphingolipid; Recombinant Proteins

2018