Page last updated: 2024-08-18

pyrroles and cc 1065

pyrroles has been researched along with cc 1065 in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's4 (15.38)18.2507
2000's18 (69.23)29.6817
2010's3 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boger, DL; Coleman, RS; Invergo, BJ; Kitos, PA; Leong, T; McLaughlin, LW; Thompson, SC; Zarrinmayeh, H1
Artico, M; Corelli, F; Massa, S; Silvestri, R; Stefancich, G1
Boger, DL; Johnson, DS1
Gupta, R; Huang, L; Lown, JW; Luo, W; Wang, Y1
Asai, A; Mizukami, T; Nakano, H; Yano, K1
Boger, DL; Brunette, SR; Hedrick, MP; Jin, Q; Santillán, A; Searcey, M; Wolkenberg, SE1
Boger, DL; Hedrick, MP; Hughes, TV1
Boger, DL; Hedrick, MP; Stauffer, F1
Castedo, L; Delamano, J; Enjo, J; Fernández, J; Grávalos, DG; Leis, R; López, C; Marcos, CF; Ríos, A; Tojo, G1
Boger, DL; Brunette, SR; Garbaccio, RM1
Balboni, G; Balzarini, J; Bando, T; Baraldi, PG; Clercq, ED; Pavani, MG; Romagnoli, R; Spalluto, G; Sugiyama, H; Tabrizi, MA1
Boger, DL; Ellis, DA; Wolkenberg, SE1
Boger, DL; Fink, BE; Hedrick, MP; Schmitt, HW1
Ambroise, Y; Boger, DL1
Searcey, M1
Boger, DL; Hedrick, MP; Hwang, I; Kastrinsky, DB; Parrish, JP; Stauffer, F1
Barone, V; Bifulco, G; Cimino, P; Gomez-Paloma, L; Improta, R; Riccio, R1
Flores, LV; Hartley, JA; Kiakos, K; Lee, M; Pennington, WT; Toth, JL; Trzupek, JD1
Bringmann, G; Krewer, B; Magull, J; Major, F; Maksimenka, K; Schuberth, I; Spiegl, DA; Tietze, LF1
Baraldi, PG; Boger, DL; Hwang, I; MacMillan, KS; Pavani, MG; Rayl, TJ; Spalluto, G; Stover, JS; Tichenor, MS; Wolkenberg, SE; Zaid, AN; Zanella, L1
Howard, T; Lee, M; Lingerfelt, B; McNulty, L; Pati, H; Townes, H1
Boger, DL; MacMillan, KS1
Krewer, B; Tietze, LF1
Boger, DL; Broward, MA; Dunwiddie, I; Lajiness, JP; Robertson, WM; Vielhauer, GA; Weir, SJ1
Jian, XH; Jin, WB; Tang, GL; Wang, LY; Wu, S; Yin, Y; Yuan, H; Zhao, J1
Cai, Y; Chan, HCS; Huang, W; Igarashi, Y; Jin, WB; Li, Y; Tang, GL; Wu, S; Yang, K; Yin, Y; Yuan, H; Yuan, S; Zhang, J; Zhou, J1

Reviews

4 review(s) available for pyrroles and cc 1065

ArticleYear
A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding.
    Chemico-biological interactions, 1990, Volume: 73, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Base Sequence; Carbamates; Chemical Phenomena; Chemistry, Physical; DNA; Duocarmycins; Humans; Indoles; Leucomycins; Macromolecular Substances; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Neoplasms; Nucleic Acid Conformation; Pyrroles; Structure-Activity Relationship

1990
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-25, Volume: 92, Issue:9

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Consensus Sequence; DNA; Duocarmycins; Indoles; Leucomycins; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Pyrroles; Structure-Activity Relationship

1995
Duocarmycins--natures prodrugs?
    Current pharmaceutical design, 2002, Volume: 8, Issue:15

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; DNA; Drug Stability; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Prodrugs; Pyrroles; Pyrrolidinones; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Structure-Activity Relationship

2009

Other Studies

22 other study(ies) available for pyrroles and cc 1065

ArticleYear
Potential antitumor agents. I. Synthesis of pyrroloindazole derivatives related to the pyrroloindole moieties of the antitumor antibiotic CC-1065.
    Il Farmaco; edizione scientifica, 1987, Volume: 42, Issue:8

    Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Duocarmycins; Indazoles; Indoles; Leucomycins; Pyrazoles; Pyrroles

1987
Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI--N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency.
    Anti-cancer drug design, 1996, Volume: 11, Issue:1

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; DNA Damage; Duocarmycins; Humans; Indoles; Leucomycins; Magnetic Resonance Spectroscopy; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured

1996
Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells.
    Cancer research, 1999, Nov-01, Volume: 59, Issue:21

    Topics: Animals; Anthramycin; Antibiotics, Antineoplastic; Apoptosis; Binding, Competitive; Cattle; Cell Nucleus; DNA; DNA Adducts; DNA-Binding Proteins; Duocarmycins; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Indoles; Leucomycins; Nuclear Proteins; Oligonucleotides; Pyrroles; Ribonucleoproteins; Thymus Gland; Tumor Cells, Cultured

1999
Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
    The Journal of organic chemistry, 2000, Jun-30, Volume: 65, Issue:13

    Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Crystallography, X-Ray; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indolequinones; Indoles; Leucomycins; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Pyrroles; Quinolones

2000
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
    The Journal of organic chemistry, 2001, Apr-06, Volume: 66, Issue:7

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Crystallography, X-Ray; DNA; Duocarmycins; Indoles; Inhibitory Concentration 50; Kinetics; Leucomycins; Leukemia L1210; Mice; Pyrroles; Pyrrolidinones

2001
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Bioorganic & medicinal chemistry letters, 2001, Aug-06, Volume: 11, Issue:15

    Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured

2001
Derivatives of methyl 5-methyl-4-oxo-1,2,4,5,8,8a- hexahydrocyclopropa[c]-pyrrolo[3,2-e]indole-7-carboxylate: a case of inverse electronic effects on the reactivity of CC-1065 derivatives.
    Journal of the American Chemical Society, 2001, May-30, Volume: 123, Issue:21

    Topics: Antibiotics, Antineoplastic; DNA; Duocarmycins; Electrons; Indoles; Leucomycins; Pyrroles

2001
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
    The Journal of organic chemistry, 2001, Jul-27, Volume: 66, Issue:15

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Duocarmycins; Humans; Indoles; Leucomycins; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrroles; Pyrrolidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet

2001
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
    Journal of medicinal chemistry, 2001, Aug-02, Volume: 44, Issue:16

    Topics: Animals; Antineoplastic Agents, Alkylating; Antiviral Agents; DNA; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indazoles; Indoles; Leucomycins; Mice; Models, Molecular; Pyrazoles; Pyrroles; Solubility; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Water

2001
Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis.
    Journal of the American Chemical Society, 2001, Sep-26, Volume: 123, Issue:38

    Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Leukemia L1210; Pyrroles; Quinolones; Stereoisomerism

2001
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
    The Journal of organic chemistry, 2001, Oct-05, Volume: 66, Issue:20

    Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Binding Sites; Combinatorial Chemistry Techniques; Cyclopropanes; DNA; DNA, Viral; Duocarmycins; Indoles; Inhibitory Concentration 50; Leucomycins; Pyrroles; Pyrrolidinones; Simian virus 40; Structure-Activity Relationship

2001
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.
    Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3

    Topics: Algorithms; Alkylation; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Magnetic Resonance Spectroscopy; Phosphates; Pyrroles

2002
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Bioorganic & medicinal chemistry, 2003, Aug-15, Volume: 11, Issue:17

    Topics: Alkylation; Amides; DNA; Duocarmycins; Indoles; Kinetics; Models, Molecular; Pyrroles; Pyrrolidinones; Sulfones

2003
Nucleophilic cyclopropane ring opening in duocarmycin SA derivatives by methanol under acid conditions: a quantum mechanical study in the gas-phase and in solution.
    The Journal of organic chemistry, 2004, Apr-16, Volume: 69, Issue:8

    Topics: Antibiotics, Antineoplastic; Catalysis; Cyclopropanes; Duocarmycins; Gases; Hydrogen-Ion Concentration; Indoles; Methanol; Molecular Structure; Pyrroles; Solutions

2004
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2005, Volume: 1, Issue:1

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; K562 Cells; Molecular Structure; Pyrroles; Stereoisomerism

2005
Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:16

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Structure; Prodrugs; Pyrroles; Stereoisomerism

2007
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
    Journal of the American Chemical Society, 2007, Nov-14, Volume: 129, Issue:45

    Topics: Alkylation; Animals; Antiparasitic Agents; Cell Line, Tumor; Combinatorial Chemistry Techniques; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Duocarmycins; Indoles; Injections, Intraperitoneal; Mice; Mice, Inbred DBA; Molecular Structure; Pyrroles; Stereoisomerism; Survival Rate; Xenograft Model Antitumor Assays

2007
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
    Molecules (Basel, Switzerland), 2004, Feb-28, Volume: 9, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Cyclization; Cyclopropanes; Duocarmycins; Humans; Indoles; Pyrroles; Pyrrolidinones

2004
Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies.
    Chemical biology & drug design, 2009, Volume: 74, Issue:3

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; beta-Galactosidase; Cell Line, Tumor; Drug Design; Duocarmycins; Glycosides; Humans; Indoles; Neoplasms; Prodrugs; Pyrroles; Stereoisomerism

2009
Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
    Journal of medicinal chemistry, 2010, Nov-11, Volume: 53, Issue:21

    Topics: Animals; Antineoplastic Agents, Alkylating; Drug Screening Assays, Antitumor; Duocarmycins; Indoles; Leukemia L1210; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Phenols; Prodrugs; Pyrroles; Stereoisomerism; Structure-Activity Relationship

2010
Unified Biosynthetic Origin of the Benzodipyrrole Subunits in CC-1065.
    ACS chemical biology, 2017, 06-16, Volume: 12, Issue:6

    Topics: Antibiotics, Antineoplastic; Biosynthetic Pathways; Cyclization; Duocarmycins; Indoles; Pyrroles; Tyrosine

2017
GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection.
    Nature communications, 2017, 11-14, Volume: 8, Issue:1

    Topics: Alkylating Agents; Animals; Bacterial Physiological Phenomena; Binding Sites; Biocatalysis; Cell Line, Tumor; Crystallography, X-Ray; DNA; DNA Topoisomerases, Type II; Drug Resistance, Bacterial; Duocarmycins; Escherichia coli; Escherichia coli Proteins; Humans; Hydrolases; Hydrolysis; Indoles; Inhibitory Concentration 50; Jurkat Cells; Mice; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Pyrroles; Recombinant Proteins; Repressor Proteins; Sequence Homology, Amino Acid; Streptomyces; Xenobiotics

2017