pyrroles and cc 1065
pyrroles has been researched along with cc 1065 in 26 studies
Research
Studies (26)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 18 (69.23) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Boger, DL; Coleman, RS; Invergo, BJ; Kitos, PA; Leong, T; McLaughlin, LW; Thompson, SC; Zarrinmayeh, H | 1 |
| Artico, M; Corelli, F; Massa, S; Silvestri, R; Stefancich, G | 1 |
| Boger, DL; Johnson, DS | 1 |
| Gupta, R; Huang, L; Lown, JW; Luo, W; Wang, Y | 1 |
| Asai, A; Mizukami, T; Nakano, H; Yano, K | 1 |
| Boger, DL; Brunette, SR; Hedrick, MP; Jin, Q; Santillán, A; Searcey, M; Wolkenberg, SE | 1 |
| Boger, DL; Hedrick, MP; Hughes, TV | 1 |
| Boger, DL; Hedrick, MP; Stauffer, F | 1 |
| Castedo, L; Delamano, J; Enjo, J; Fernández, J; Grávalos, DG; Leis, R; López, C; Marcos, CF; Ríos, A; Tojo, G | 1 |
| Boger, DL; Brunette, SR; Garbaccio, RM | 1 |
| Balboni, G; Balzarini, J; Bando, T; Baraldi, PG; Clercq, ED; Pavani, MG; Romagnoli, R; Spalluto, G; Sugiyama, H; Tabrizi, MA | 1 |
| Boger, DL; Ellis, DA; Wolkenberg, SE | 1 |
| Boger, DL; Fink, BE; Hedrick, MP; Schmitt, HW | 1 |
| Ambroise, Y; Boger, DL | 1 |
| Searcey, M | 1 |
| Boger, DL; Hedrick, MP; Hwang, I; Kastrinsky, DB; Parrish, JP; Stauffer, F | 1 |
| Barone, V; Bifulco, G; Cimino, P; Gomez-Paloma, L; Improta, R; Riccio, R | 1 |
| Flores, LV; Hartley, JA; Kiakos, K; Lee, M; Pennington, WT; Toth, JL; Trzupek, JD | 1 |
| Bringmann, G; Krewer, B; Magull, J; Major, F; Maksimenka, K; Schuberth, I; Spiegl, DA; Tietze, LF | 1 |
| Baraldi, PG; Boger, DL; Hwang, I; MacMillan, KS; Pavani, MG; Rayl, TJ; Spalluto, G; Stover, JS; Tichenor, MS; Wolkenberg, SE; Zaid, AN; Zanella, L | 1 |
| Howard, T; Lee, M; Lingerfelt, B; McNulty, L; Pati, H; Townes, H | 1 |
| Boger, DL; MacMillan, KS | 1 |
| Krewer, B; Tietze, LF | 1 |
| Boger, DL; Broward, MA; Dunwiddie, I; Lajiness, JP; Robertson, WM; Vielhauer, GA; Weir, SJ | 1 |
| Jian, XH; Jin, WB; Tang, GL; Wang, LY; Wu, S; Yin, Y; Yuan, H; Zhao, J | 1 |
| Cai, Y; Chan, HCS; Huang, W; Igarashi, Y; Jin, WB; Li, Y; Tang, GL; Wu, S; Yang, K; Yin, Y; Yuan, H; Yuan, S; Zhang, J; Zhou, J | 1 |
Reviews
4 review(s) available for pyrroles and cc 1065
| Article | Year |
|---|---|
A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding.
Topics: Animals; Antibiotics, Antineoplastic; Base Sequence; Carbamates; Chemical Phenomena; Chemistry, Physical; DNA; Duocarmycins; Humans; Indoles; Leucomycins; Macromolecular Substances; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Neoplasms; Nucleic Acid Conformation; Pyrroles; Structure-Activity Relationship | 1990 |
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Consensus Sequence; DNA; Duocarmycins; Indoles; Leucomycins; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Pyrroles; Structure-Activity Relationship | 1995 |
Duocarmycins--natures prodrugs?
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; DNA; Drug Stability; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Prodrugs; Pyrroles; Pyrrolidinones; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Structure-Activity Relationship | 2009 |
Other Studies
22 other study(ies) available for pyrroles and cc 1065
| Article | Year |
|---|---|
Potential antitumor agents. I. Synthesis of pyrroloindazole derivatives related to the pyrroloindole moieties of the antitumor antibiotic CC-1065.
Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Duocarmycins; Indazoles; Indoles; Leucomycins; Pyrazoles; Pyrroles | 1987 |
Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI--N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; DNA Damage; Duocarmycins; Humans; Indoles; Leucomycins; Magnetic Resonance Spectroscopy; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells.
Topics: Animals; Anthramycin; Antibiotics, Antineoplastic; Apoptosis; Binding, Competitive; Cattle; Cell Nucleus; DNA; DNA Adducts; DNA-Binding Proteins; Duocarmycins; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Indoles; Leucomycins; Nuclear Proteins; Oligonucleotides; Pyrroles; Ribonucleoproteins; Thymus Gland; Tumor Cells, Cultured | 1999 |
Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Crystallography, X-Ray; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indolequinones; Indoles; Leucomycins; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Pyrroles; Quinolones | 2000 |
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Crystallography, X-Ray; DNA; Duocarmycins; Indoles; Inhibitory Concentration 50; Kinetics; Leucomycins; Leukemia L1210; Mice; Pyrroles; Pyrrolidinones | 2001 |
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured | 2001 |
Derivatives of methyl 5-methyl-4-oxo-1,2,4,5,8,8a- hexahydrocyclopropa[c]-pyrrolo[3,2-e]indole-7-carboxylate: a case of inverse electronic effects on the reactivity of CC-1065 derivatives.
Topics: Antibiotics, Antineoplastic; DNA; Duocarmycins; Electrons; Indoles; Leucomycins; Pyrroles | 2001 |
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Duocarmycins; Humans; Indoles; Leucomycins; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrroles; Pyrrolidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet | 2001 |
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
Topics: Animals; Antineoplastic Agents, Alkylating; Antiviral Agents; DNA; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indazoles; Indoles; Leucomycins; Mice; Models, Molecular; Pyrazoles; Pyrroles; Solubility; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Water | 2001 |
Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Leukemia L1210; Pyrroles; Quinolones; Stereoisomerism | 2001 |
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Binding Sites; Combinatorial Chemistry Techniques; Cyclopropanes; DNA; DNA, Viral; Duocarmycins; Indoles; Inhibitory Concentration 50; Leucomycins; Pyrroles; Pyrrolidinones; Simian virus 40; Structure-Activity Relationship | 2001 |
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.
Topics: Algorithms; Alkylation; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Magnetic Resonance Spectroscopy; Phosphates; Pyrroles | 2002 |
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Alkylation; Amides; DNA; Duocarmycins; Indoles; Kinetics; Models, Molecular; Pyrroles; Pyrrolidinones; Sulfones | 2003 |
Nucleophilic cyclopropane ring opening in duocarmycin SA derivatives by methanol under acid conditions: a quantum mechanical study in the gas-phase and in solution.
Topics: Antibiotics, Antineoplastic; Catalysis; Cyclopropanes; Duocarmycins; Gases; Hydrogen-Ion Concentration; Indoles; Methanol; Molecular Structure; Pyrroles; Solutions | 2004 |
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; K562 Cells; Molecular Structure; Pyrroles; Stereoisomerism | 2005 |
Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Structure; Prodrugs; Pyrroles; Stereoisomerism | 2007 |
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Topics: Alkylation; Animals; Antiparasitic Agents; Cell Line, Tumor; Combinatorial Chemistry Techniques; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Duocarmycins; Indoles; Injections, Intraperitoneal; Mice; Mice, Inbred DBA; Molecular Structure; Pyrroles; Stereoisomerism; Survival Rate; Xenograft Model Antitumor Assays | 2007 |
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
Topics: Antineoplastic Agents, Alkylating; Cyclization; Cyclopropanes; Duocarmycins; Humans; Indoles; Pyrroles; Pyrrolidinones | 2004 |
Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; beta-Galactosidase; Cell Line, Tumor; Drug Design; Duocarmycins; Glycosides; Humans; Indoles; Neoplasms; Prodrugs; Pyrroles; Stereoisomerism | 2009 |
Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
Topics: Animals; Antineoplastic Agents, Alkylating; Drug Screening Assays, Antitumor; Duocarmycins; Indoles; Leukemia L1210; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Phenols; Prodrugs; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2010 |
Unified Biosynthetic Origin of the Benzodipyrrole Subunits in CC-1065.
Topics: Antibiotics, Antineoplastic; Biosynthetic Pathways; Cyclization; Duocarmycins; Indoles; Pyrroles; Tyrosine | 2017 |
GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection.
Topics: Alkylating Agents; Animals; Bacterial Physiological Phenomena; Binding Sites; Biocatalysis; Cell Line, Tumor; Crystallography, X-Ray; DNA; DNA Topoisomerases, Type II; Drug Resistance, Bacterial; Duocarmycins; Escherichia coli; Escherichia coli Proteins; Humans; Hydrolases; Hydrolysis; Indoles; Inhibitory Concentration 50; Jurkat Cells; Mice; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Pyrroles; Recombinant Proteins; Repressor Proteins; Sequence Homology, Amino Acid; Streptomyces; Xenobiotics | 2017 |