Page last updated: 2024-08-18

pyrroles and brivanib

pyrroles has been researched along with brivanib in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (23.08)29.6817
2010's10 (76.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barbosa, S; Barrish, JC; Bhide, RS; Borzilleri, RM; Cai, ZW; Chao, S; D'Arienzo, C; Derbin, G; Fargnoli, J; Fura, A; Hunt, JT; Jeyaseelan, R; Kamath, A; Kim, SH; Kukral, D; Leavitt, K; Leith, L; Lombardo, LJ; Marathe, P; Mathur, A; Mortillo, S; Qian, L; Vyas, V; Wautlet, B; Wei, D; Wu, LI; Zhang, YZ; Zheng, X1
Barbosa, S; Barrish, JC; Bhide, RS; Borzilleri, RM; Cai, ZW; D'Arienzo, C; Derbin, G; Fan, J; Fargnoli, J; Hunt, JT; Jeyaseelan, R; Kamath, A; Kukral, DW; Lombardo, LJ; Marathe, P; Mortillo, S; Qian, L; Robl, JA; Shi, Z; Wautlet, BS; Wei, D; Wu, L; Zhang, Y; Zheng, X1
Bhide, R; D'Arienzo, C; Fargnoli, J; Kamath, AV; Marathe, PH; Zhang, Y1
Barrish, JC; Bhide, RS; Cai, ZW; Fargnoli, J; Galbraith, S; Henley, BJ; Hunt, JT; Jeyaseelan, R; Krishnan, B; Kukral, D; Lewin, AC; Lombardo, LJ; Malone, H; Mortillo, S; Wautlet, BS1
Fargnoli, J; Jordan, VC; Kim, HR; Klein-Szanto, AJ; Li, T; Oseni, S; Patel, RR; Pyle, JR; Ross, EA; Sengupta, S; Zhu, F1
Fischer, BS; Gan, J; Ganapathi, R; Gong, J; Iyer, R; Masson, E; Mekhail, T; Patricia, D; Pursley, J; Williams, D1
Dempke, WC; Zippel, R1
Baudelet, C; Finn, RS; Harris, R; Ismail, F; Karwal, M; Kim, JS; Li, RK; Park, JW; Raoul, JL; Thomas, M; Walters, I1
Diaz-Padilla, I; Siu, LL1
Abbas, A; Jones, H; Kingston, GT; Zurek, A1
Chang, AY; Wang, M1
Bello, E; Berndt, A; Camboni, G; Cavalletti, E; Colella, G; D'Incalci, M; Damia, G; Forestieri, D; Giavazzi, R; Licandro, SA; Richter, P; Taraboletti, G; Zucchetti, M1
Kalyan, A; Kulik, L; Nimeiri, H1

Reviews

3 review(s) available for pyrroles and brivanib

ArticleYear
Brivanib, a novel dual VEGF-R2/bFGF-R inhibitor.
    Anticancer research, 2010, Volume: 30, Issue:11

    Topics: Alanine; Clinical Trials as Topic; Humans; Neoplasms; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Triazines; Vascular Endothelial Growth Factor Receptor-2

2010
Brivanib alaninate for cancer.
    Expert opinion on investigational drugs, 2011, Volume: 20, Issue:4

    Topics: Alanine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Triazines; Vascular Endothelial Growth Factor Receptor-2

2011
Systemic therapy of hepatocellular carcinoma: current and promising.
    Clinics in liver disease, 2015, Volume: 19, Issue:2

    Topics: Alanine; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Combined Modality Therapy; Hepatectomy; Humans; Indoles; Liver Neoplasms; Liver Transplantation; Niacinamide; Phenylurea Compounds; Preoperative Care; Proto-Oncogene Proteins c-met; Pyrroles; Signal Transduction; Sorafenib; Sunitinib; TOR Serine-Threonine Kinases; Triazines

2015

Trials

2 trial(s) available for pyrroles and brivanib

ArticleYear
Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:11

    Topics: Administration, Oral; Aged; Alanine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Feces; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Pyrroles; Triazines

2010
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-01, Volume: 17, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Carcinoma, Hepatocellular; Disease-Free Survival; Female; Humans; Liver Neoplasms; Male; Middle Aged; Pyrroles; Treatment Outcome; Triazines; Tumor Burden

2011

Other Studies

8 other study(ies) available for pyrroles and brivanib

ArticleYear
Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.
    Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7

    Topics: Alanine; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Prodrugs; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Triazines; Vascular Endothelial Growth Factor Receptor-2

2006
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth fa
    Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6

    Topics: Administration, Oral; Alanine; Animals; Biological Availability; Carcinoma; Cell Proliferation; Clinical Trials, Phase II as Topic; Drug Design; Drug Evaluation, Preclinical; Humans; Intestines; Liver; Lung Neoplasms; Mice; Microsomes; Molecular Structure; Prodrugs; Protein Kinase Inhibitors; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Solubility; Stereoisomerism; Triazines; Vascular Endothelial Growth Factor Receptor-2; Water; Xenograft Model Antitumor Assays

2008
Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate.
    Cancer chemotherapy and pharmacology, 2009, Volume: 65, Issue:1

    Topics: Administration, Oral; Alanine; Animals; Antineoplastic Agents; Biological Availability; Brain; Caco-2 Cells; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Injections, Intravenous; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prodrugs; Pyrroles; Rats; Solubility; Tissue Distribution; Triazines; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2009
The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:2

    Topics: Alanine; Animals; Antigens, CD34; Cell Line, Tumor; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Laminin; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Proteoglycans; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Time Factors; Triazines; Vascular Endothelial Growth Factor Receptor-2

2010
Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: a potential clinical application of angiogenesis inhibitors.
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:9

    Topics: Alanine; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Random Allocation; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Tamoxifen; Transplantation, Heterologous; Triazines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2010
Malignant peripheral nerve sheath tumour presenting as a pneumothorax.
    The British journal of radiology, 2011, Volume: 84, Issue:1006

    Topics: Adult; Alanine; Antineoplastic Agents; Fatal Outcome; Humans; Male; Nerve Sheath Neoplasms; Peripheral Nervous System Neoplasms; Pneumothorax; Pyrroles; Radiography, Thoracic; Triazines

2011
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma.
    Anti-cancer drugs, 2013, Volume: 24, Issue:3

    Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines

2013
The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:2

    Topics: Alanine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Synergism; Female; Humans; Indoles; Mice; Mice, Nude; Paclitaxel; Protein Kinase Inhibitors; Pyrroles; Rabeprazole; Random Allocation; Sunitinib; Triazines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2013