Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and a 867744

pyrroles has been researched along with a 867744 in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anderson, DJ; Briggs, CA; Bunnelle, WH; Faghih, R; Gopalakrishnan, M; Grønlien, JH; Håkerud, M; Malysz, J; Thorin-Hagene, K; Ween, H; Wetterstrand, C1
Briggs, CA; Bunnelle, WH; Curtis, MP; El-Kouhen, R; Faghih, R; Gfesser, GA; Gopalakrishnan, M; Gopalakrishnan, SM; Gronlien, JH; Malysz, J; Marsh, KC; Radek, RJ; Robb, HM; Sarris, KA; Ween, H; Wetterstrand, C1
Gopalakrishnan, M; Hu, M; Li, J1
Ahring, PK; Anderson, DJ; Briggs, CA; Bunnelle, WH; Dyhring, T; Gopalakrishnan, M; Gopalakrishnan, S; Grønlien, JH; Gubbins, E; Håkerud, M; Helfrich, R; Hu, M; Ji, J; Li, J; Malysz, J; Meyer, MD; Nielsen, EØ; Peters, D; Puttfarcken, PS; Thorin-Hagene, K; Timmermann, DB; Ween, H1
Andersen, E; Gopalakrishnan, M; Grønlien, JH; Lee, CH; Malysz, J; Thorin-Hagene, K; Ween, H1
Chatzidaki, A; Millar, NS; Newcombe, J; Sheppard, TD; Topf, M1

Other Studies

6 other study(ies) available for pyrroles and a 867744

ArticleYear
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:1

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzenesulfonamides; Cell Line; Cholinergic Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sulfonamides; Xenopus laevis

2009
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
    Journal of medicinal chemistry, 2009, May-28, Volume: 52, Issue:10

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzenesulfonamides; Brain; Cells, Cultured; Drug Discovery; Mice; Microsomes; Oocytes; Patch-Clamp Techniques; Pharmacokinetics; Pyrroles; Receptors, Nicotinic; Sensory Gating; Sulfonamides; Xenopus laevis

2009
Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.
    British journal of pharmacology, 2009, Volume: 158, Issue:8

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Survival; Electrophysiology; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Nicotinic Agonists; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sulfonamides

2009
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
    The Journal of pharmacology and experimental therapeutics, 2010, Sep-01, Volume: 334, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Isoxazoles; Male; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substrate Specificity; Sulfonamides; Xenopus

2010
Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells.
    Neurochemistry international, 2010, Volume: 57, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Benzamides; Brain Neoplasms; Bridged Bicyclo Compounds; Calcium Channel Blockers; Calcium Signaling; Calcium-Transporting ATPases; Cell Line, Tumor; Data Interpretation, Statistical; Diltiazem; Electrophysiology; Endoplasmic Reticulum; Humans; Neuroblastoma; Nicotinic Agonists; Nitrendipine; Patch-Clamp Techniques; Pyrroles; Receptors, Nicotinic; Sulfonamides

2010
Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.
    Molecular pharmacology, 2018, Volume: 93, Issue:2

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Humans; Models, Molecular; Molecular Docking Simulation; Mutagenesis, Site-Directed; Naphthalenes; Nicotinic Agonists; Protein Binding; Pyrroles; Quinolines; Radioligand Assay; Sequence Homology, Amino Acid; Sulfonamides; Torpedo; Xenopus

2018