phenytoin and rifampin

phenytoin has been researched along with rifampin in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (33.77)	18.7374
1990's	14 (18.18)	18.2507
2000's	13 (16.88)	29.6817
2010's	22 (28.57)	24.3611
2020's	2 (2.60)	2.80

Authors

Authors	Studies
Andersson, K; Borg, P; Frostell-Karlsson, A; Hämäläinen, M; Karlsson, R; Remaeus, A; Roos, H	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Al-Ach, NN; Al-Tel, TH; Alshihabi, AM; Anbar, HS; El-Awady, R; El-Gamal, MI; El-Gamal, R; Kalla, RR; Munther, MA; Sbenati, RM; Shahin, AI; Shehata, MK; Tarazi, H; Tokatly, RT; Wahba, MM; Zaraei, SO	1
Breckenridge, AM; Ohnhaus, EE; Park, BK	1
Christensen, LK; Hansen, JM	1
Addington, WW	1
Storstein, L	1
Remmer, H	1
Johnson, J	1
Zbinden, G	1
Denning, DW; Graybill, JR; Hanson, LH; Pappagianis, D; Rinaldi, MG; Sharkey, PK; Stevens, DA; Tucker, RM	1
Cone, LA; Simmons, JC; Sonnenshein, MA; Woodard, DR	1
Sekihara, H	1
Baciewicz, AM; Bekemeyer, WB; Self, TH	1
Weissel, M	1
Abajo, FJ	1
Debreczeni, LA; Herjavecz, I; Szeitz, A	1
Bircher, J; Blume, R; Bock, KW; Ullrich, D; Wiltfang, J	1
Bolt, HM	1
Hansen, JE; Kampmann, JP; Kay, L; Kristensen, M; Skovsted, L; Svendsen, TL; Vergman, B	1
Freshwater, DB; Jacques, S; Randle, RE; Shelden, CH	1
Pelkonen, RO; Puukka, M; Sotaniemi, EA	1
Perry, W; Stamp, TC	1
Elias, AN; Gwinup, G	1
Belpaire, FM; Bogaert, MG; D'Heer, F; De Rick, A; Rosseel, MT	1
Bint, AJ; Burtt, I	1
Greim, H	1
Linares Rodríguez, A; Recarte Alvarez, J; Rodrigo Sáez, L; Valerdiz Casasola, S	1
Aitio, A; Aitio, ML; Haataja, M; Mansury, L; Tala, E	1
Dayton, PG; Olson, WA; Pruitt, AW	1
Borisova, LN; Kovalev, IE	1
Breimer, DD; Richter, E; Zilly, W	1
Gibson, LE; Kuechle, MK; Leiferman, KM; Maynard, B; Peters, MS; Stegemeir, E	1
Ichikawa, Y; Kawai, S	1
Chandra, RS; Dalvi, SS; Karnad, PD; Kshirsagar, NA; Powar, HS	1
Bachmann, KA; Jauregui, L	1
Hirata, M; Nishibe, Y	1
Beck, WT; Schuetz, EG; Schuetz, JD	1
Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y	1
Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM	1
Andres, A; Carreño, A; Cubas, A; Delgado, M; Dominguez-Gil, B; Herrero, JC; Latorre, A; Manzanares, C; Morales, E; Morales, JM; Moreno, M	1
Madras, JL; Poujade, F; Saulnier, JL; Schlatter, J	1
Akinloye, O; Akinmoladun, CO; Emerole, GO; Farombi, EO	1
Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E	1
Faucette, SR; Gilbert, D; Jolley, SL; LeCluyse, EL; Negishi, M; Sueyoshi, T; Wang, H	1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T	1
Gkiatas, K; Kararizos, G; Kararizou, E; Likomanos, D; Markou, I; Triantafyllou, N; Vassilopoulos, D; Zalonis, I; Zambelis, T	1
de Morais, SM; Fahmi, OA; Liras, JL; Maurer, TS; Mills, JB; Ripp, SL; Trevena, KA	1
Berishvili, E; Gupta, S; Joseph, B; Kumaran, V; Wu, YM	1
Gupta, R; Gupta, S	1
Aoyama, E; Kamiguchi, N; Moriwaki, T; Okuda, T	1
Bandi, S; Berishvili, E; Cheng, K; Gupta, S; Joseph, B; Singhania, R; Wu, YM	1
Chen, SC; Dolton, MJ; McLachlan, AJ; Ng, K; Pont, LG; Ray, JE	1
Chen, SC; Dolton, MJ; McLachlan, AJ; Ng, K; Pont, L; Ray, JE	1
Hurdle, AC; Twilla, JD; Van Berkel, MA	1
Gribakina, OG; Kolyvanov, GB; Novitskaia, IaG; Seredenin, SB; Smirnov, VV; Zherdev, VP	1
Alves, G; Falcão, A; Ferreira, A; Rodrigues, M; Silvestre, S	1
Brüggemann, RJ; Burger, DM; Dolton, MJ; McLachlan, AJ	1
Zhang, T	1
Dixit, V; Hariparsad, N; Moore, A; Tsao, H	1
Almond, LM; Gardner, I; Hatley, O; Jamei, M; Kenny, JR; Mukadam, S; Okialda, K; Rostami-Hodjegan, A; Rowland-Yeo, K; Tay, S; Wong, S	1
Douxfils, J; Hainaut, P; Hardy, M; Larock, AS; Lessire, S; Mullier, F; Sennesael, AL; Spinewine, A	1

Reviews

9 review(s) available for phenytoin and rifampin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Modification of the action of drugs by inhibition of their metabolism]. Recenti progressi in medicina, 1979, Volume: 67, Issue:3 Topics: Antipyrine; Barbiturates; Drug Interactions; Enzyme Induction; Enzyme Repression; Ethanol; gamma-Glutamyltransferase; Glucaric Acid; Humans; Nicotine; Pharmaceutical Preparations; Pharmacology; Phenytoin; Rifampin	1979
Drug interactions with oral sulphonylurea hypoglycaemic drugs. Drugs, 1977, Volume: 13, Issue:1 Topics: Allopurinol; Analgesics; Anticoagulants; Chloramphenicol; Chlorpropamide; Disulfiram; Drug Interactions; Ethanol; Glyburide; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Monoamine Oxidase Inhibitors; Novobiocin; Phenylbutazone; Phenytoin; Probenecid; Propranolol; Rifampin; Sulfonamides; Sulfonylurea Compounds; Tolbutamide	1977
[Modification of peripheral thyroid hormone metabolism by drugs]. Acta medica Austriaca, 1988, Volume: 15 Suppl 1 Topics: Amiodarone; Antipyrine; Dexamethasone; Heparin; Humans; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Rifampin; Thiouracil; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine	1988
Effects of some clinically encountered drugs on steroid synthesis and degradation. Metabolism: clinical and experimental, 1980, Volume: 29, Issue:6 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Drug Interactions; Ethanol; Fetus; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hydroxycholecalciferols; Liver; Metyrapone; Mitotane; Phenobarbital; Phenytoin; Rifampin; Spironolactone; Steroids	1980
Adverse antibiotic drug interactions. Drugs, 1980, Volume: 20, Issue:1 Topics: Aminosalicylic Acid; Antacids; Anti-Bacterial Agents; Biological Availability; Contraceptives, Oral; Digitoxin; Drug Interactions; Gastrointestinal Motility; Humans; Hydrogen-Ion Concentration; Kidney; Metals; Phenobarbital; Phenytoin; Rifampin; Sulfonamides; Tetracyclines; Warfarin	1980
[Enzyme induction in the liver changes drug activity]. Medizinische Klinik, 1980, Sep-26, Volume: 75, Issue:20 Topics: Animals; Barbiturates; Carbamazepine; Chlorpromazine; Drug Interactions; Enzyme Induction; Glutethimide; Humans; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Rifampin; Time Factors	1980
Drug-induced linear IgA bullous dermatosis: report of six cases and review of the literature. Journal of the American Academy of Dermatology, 1994, Volume: 30, Issue:2 Pt 1 Topics: Aged; Autoimmune Diseases; Basement Membrane; Captopril; Drug Eruptions; Female; Humans; Immunoglobulin A; Male; Phenytoin; Rifampin; Skin; Skin Diseases, Vesiculobullous; Somatostatin; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin	1994
[Drug interactions between glucocorticoids and other drugs]. Nihon rinsho. Japanese journal of clinical medicine, 1994, Volume: 52, Issue:3 Topics: Barbiturates; Drug Interactions; Glucocorticoids; Humans; Phenytoin; Prednisolone; Protein Binding; Rifampin	1994

Trials

1 trial(s) available for phenytoin and rifampin

Article	Year
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3 Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid	1993

Article

Year

Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo.

Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3

Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid

1993

Other Studies

67 other study(ies) available for phenytoin and rifampin

Article	Year
Biosensor analysis of the interaction between immobilized human serum albumin and drug compounds for prediction of human serum albumin binding levels. Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10 Topics: Binding Sites; Biosensing Techniques; Digitoxin; Drug Stability; Humans; Molecular Weight; Naproxen; Orosomucoid; Pharmaceutical Preparations; Protein Binding; Quinine; Rifampin; Ritonavir; Serum Albumin; Solvents; Warfarin	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity. European journal of medicinal chemistry, 2022, Aug-05, Volume: 238 Topics: Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydroxyquinolines; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Quinolines; Sorafenib; Structure-Activity Relationship	2022
The side effects and interactions of antituberculosis drugs. Chest, 1979, Volume: 76, Issue:6 Suppl Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Ethambutol; Female; Humans; Immunosuppression Therapy; Isoniazid; Optic Neuritis; Phenytoin; Pregnancy; Rifampin; Streptomycin; Thrombocytopenia	1979
Studies on digitalis. V. The influence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin. Clinical pharmacology and therapeutics, 1976, Volume: 20, Issue:1 Topics: Blood Proteins; Digitoxin; Digoxin; Drug Interactions; Heparin; Humans; Kidney; Kidney Transplantation; Liver; Phenytoin; Procainamide; Protein Binding; Renal Dialysis; Rifampin; Transplantation, Homologous; Uremia	1976
[Biotransformation and its modification by barbiturates]. Zeitschrift fur Gastroenterologie, 1977, Volume: 15, Issue:6 Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Liver Diseases; Phenobarbital; Phenytoin; Rifampin	1977
Letter: Epanutin and isoniazid interaction. British medical journal, 1975, Jan-18, Volume: 1, Issue:5950 Topics: Adult; Carbamazepine; Drug Interactions; Electroencephalography; Epilepsy; Ethambutol; Ethosuximide; Female; Humans; Isoniazid; Phenobarbital; Phenytoin; Rifampin	1975
[Dangers of drug combinations (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, Mar-23, Volume: 65, Issue:11 Topics: Anticoagulants; Barbiturates; Contraceptives, Oral, Hormonal; Drug Antagonism; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Imipramine; Intestinal Absorption; Monoamine Oxidase Inhibitors; Phenobarbital; Phenytoin; Psychoses, Substance-Induced; Rifampin	1976
Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 14, Issue:1 Topics: Adult; Aged; Antifungal Agents; Azoles; Carbamazepine; Coccidioides; Cryptococcus neoformans; Drug Interactions; Drug Therapy, Combination; Female; Fluconazole; Humans; Itraconazole; Ketoconazole; Malassezia; Male; Middle Aged; Mycoses; Phenytoin; Rifampin	1992
Drug interactions in patients with AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 15, Issue:6 Topics: Acquired Immunodeficiency Syndrome; Adult; Clofazimine; Drug Interactions; Humans; Male; Phenytoin; Rifampin	1992
[Drug enhancement of cortisol and glucocorticoid metabolism]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1992, Apr-10, Volume: 81, Issue:4 Topics: Adrenal Insufficiency; Drug Interactions; Ephedrine; Half-Life; Humans; Hydrocortisone; Methylprednisolone; Phenobarbital; Phenytoin; Prednisolone; Rifampin	1992
Update on rifampin drug interactions. Archives of internal medicine, 1987, Volume: 147, Issue:3 Topics: Adrenergic beta-Antagonists; Cyclosporins; Digoxin; Drug Interactions; Humans; Ketoconazole; Phenytoin; Rifampin; Theophylline; Verapamil	1987
Phenytoin interaction with rifampicin. BMJ (Clinical research ed.), 1988, Oct-22, Volume: 297, Issue:6655 Topics: Aged; Aged, 80 and over; Drug Interactions; Epilepsies, Partial; Humans; Male; Phenytoin; Rifampin; Tuberculosis, Pulmonary	1988
Effects of drugs on aminophylline elimination in rats. Arzneimittel-Forschung, 1988, Volume: 38, Issue:12 Topics: Aminophylline; Animals; Behavior, Animal; Carbamazepine; Cimetidine; Drug Combinations; Drug Interactions; Erythromycin; Female; Half-Life; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988
Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking. European journal of clinical pharmacology, 1987, Volume: 31, Issue:6 Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Female; Glucuronates; Humans; Hydrocortisone; Kinetics; Male; Middle Aged; Phenytoin; Rifampin; Smoking; Spectrophotometry, Ultraviolet	1987
[Drug interactions in the use of steroid hormones, especially oral contraceptives]. Archives of gynecology, 1985, Volume: 238, Issue:1-4 Topics: Biotransformation; Contraceptives, Oral, Hormonal; Cytochrome P-450 CYP1A1; Drug Interactions; Female; Humans; Hydroxylation; Liver; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Rifampin; Steroid Hydroxylases	1985
Influence of rifampicin and isoniazid on the kinetics of phenytoin. British journal of clinical pharmacology, 1985, Volume: 20, Issue:4 Topics: Acetylation; Adult; Aged; Ethambutol; Female; Half-Life; Humans; Isoniazid; Kinetics; Male; Middle Aged; Phenotype; Phenytoin; Rifampin; Tuberculosis, Pulmonary	1985
Supratentorial tuberculoma: a case report and review. Bulletin of the Los Angeles neurological societies, 1974, Volume: 39, Issue:2 Topics: Adult; Brain Diseases; Cerebral Angiography; Dexamethasone; Diagnosis, Differential; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Isoniazid; Mycobacterium tuberculosis; Phenytoin; Rifampin; Streptomycin; Tuberculoma	1974
Measurement of hepatic drug-metabolizing enxyme activity in man. Comparison of three different assays. European journal of clinical pharmacology, 1980, Volume: 17, Issue:4 Topics: Adult; Aged; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucaric Acid; Hepatitis; Histamine H1 Antagonists; Humans; Liver; Liver Cirrhosis; Male; Medroxyprogesterone; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Prednisolone; Rifampin	1980
Urinary D-glucaric acid excretion during rifampicin/isoniazid and anticonvulsant enzyme induction. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:5 Topics: Adolescent; Adult; Aged; Enzyme Induction; Female; gamma-Glutamyltransferase; Glucaric Acid; Glucuronidase; Glutethimide; Humans; Isoniazid; Liver; Male; Middle Aged; Phenytoin; Rifampin; Sugar Acids	1984
Enhanced serum binding of propranolol and oxprenolol and microsomal enzyme induction by rifampicin in the dog. Biochemical pharmacology, 1983, Mar-15, Volume: 32, Issue:6 Topics: Animals; Chemical Phenomena; Chemistry; Dogs; Enzyme Induction; Female; Male; Microsomes; Oxprenolol; Phenytoin; Propranolol; Protein Binding; Rifampin	1983
[Hepatitis caused by drugs. 4]. Revista espanola de las enfermedades del aparato digestivo, 1982, Volume: 62, Issue:4 Topics: Adult; Aminosalicylic Acid; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Halothane; Humans; Iproniazid; Isoniazid; Middle Aged; Nitrofurantoin; Phenytoin; Prognosis; Rifampin; Sulfonamides	1982
The effect of enzyme induction on the metabolism of disopyramide in man. British journal of clinical pharmacology, 1981, Volume: 11, Issue:3 Topics: Adult; Disopyramide; Enzyme Induction; Female; Humans; Male; Middle Aged; Phenytoin; Pyridines; Rifampin; Time Factors	1981
Plasma concentrations of isoniazid in children with tuberculous infections. Pediatrics, 1981, Volume: 67, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Injections, Intramuscular; Isoniazid; Male; Phenytoin; Rifampin; Tuberculin Test; Tuberculosis, Meningeal; Tuberculosis, Pulmonary	1981
[Effect of inducers of mixed-function microsomal oxidases on the immune response of mice induced by heterologous erythrocytes]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1981, Issue:4 Topics: Animals; Anti-Anxiety Agents; Antibody Formation; Benzodiazepines; Benzodiazepinones; Cytochrome P-450 Enzyme System; DDT; Diazepam; Enzyme Induction; Erythrocytes; Male; Methylcholanthrene; Mice; Phenobarbital; Phenytoin; Rifampin; Sheep	1981
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents. European journal of clinical pharmacology, 1980, Volume: 17, Issue:3 Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobarbital; Humans; Inactivation, Metabolic; Kinetics; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Phenytoin; Rifampin	1980
Phenytoin toxicity due to rifampicin induced hepatic dysfunction. The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:8 Topics: Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Phenytoin; Rifampin; Tuberculosis	1993
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:8 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases	1995
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Molecular pharmacology, 1996, Volume: 49, Issue:2 Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil	1996
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:2 Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifibrinolytic Agents; Blood Coagulation; Carbamazepine; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Phenytoin; Piperidines; Prothrombin Time; Rifampin; Sulfonamides; Thromboembolism; Thromboplastin; Vitamin K 1; Warfarin	1998
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3 Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics	1999
Clinical management of tacrolimus drug interactions in renal transplant patients. Transplantation proceedings, 1999, Volume: 31, Issue:6 Topics: Adult; Aged; Antifungal Agents; Candidiasis; Drug Interactions; Erythromycin; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Phenytoin; Postoperative Complications; Rifampin; Tacrolimus	1999
[Drug interactions with methadone]. Presse medicale (Paris, France : 1983), 1999, Sep-04, Volume: 28, Issue:25 Topics: Anticonvulsants; Antitubercular Agents; Antiviral Agents; Drug Interactions; Drug Therapy; Humans; Methadone; Phenytoin; Psychotropic Drugs; Rifampin	1999
Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin. Clinica chimica acta; international journal of clinical chemistry, 1999, Volume: 289, Issue:1-2 Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Chlordiazepoxide; Cytosol; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Griseofulvin; Inactivation, Metabolic; Liver; Male; Microsomes, Liver; Organ Size; Oxidoreductases, O-Demethylating; Phenytoin; Phosphatidate Phosphatase; Rats; Rats, Wistar; Rifampin; Triglycerides	1999
Paraquat detoxicative system in the mouse liver postmitochondrial fraction. Archives of biochemistry and biophysics, 2002, Jun-01, Volume: 402, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E	2002
Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Clotrimazole; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Gene Expression Regulation; Hepatocytes; Humans; Hydroxylation; Immunoblotting; Ligands; Oxidoreductases, N-Demethylating; Phenytoin; Polymerase Chain Reaction; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Rifampin; RNA, Messenger; Transcription Factors	2003
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin	2005
Paraneoplastic limbic encephalitis presenting as acute viral encephalitis. Journal of neuro-oncology, 2005, Volume: 75, Issue:2 Topics: Acute Disease; Acyclovir; Anti-Bacterial Agents; Anticonvulsants; Carcinoma, Renal Cell; Cerebrospinal Fluid; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalography; Encephalitis, Viral; Enoxaparin; Ethambutol; Follow-Up Studies; Herpesvirus 1, Human; Humans; Isoniazid; Limbic Encephalitis; Limbic System; Magnetic Resonance Imaging; Male; Meningoencephalitis; Methylprednisolone; Middle Aged; Nephrectomy; Neuropsychological Tests; Paraneoplastic Syndromes, Nervous System; Phenytoin; Rifampin; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Vancomycin	2005
Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:10 Topics: Algorithms; Carbamazepine; Cell Line; Cell Proliferation; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Nifedipine; Phenobarbital; Phenytoin; Pioglitazone; Reproducibility of Results; Rifampin; Rosiglitazone; Sulfinpyrazone; Thiazolidinediones	2006
Hepatocyte transplantation and drug-induced perturbations in liver cell compartments. Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:1 Topics: Animals; Antibiotics, Antitubercular; Anticonvulsants; Cell Proliferation; Dipeptidyl Peptidase 4; Endothelial Cells; Female; Hepatocytes; Liver; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Phenytoin; Rifampin; Time Factors; Transplants	2008
Exanthematous allergic drug reactions due to four chemically unrelated drugs. Dermatology online journal, 2008, Jan-15, Volume: 14, Issue:1 Topics: Adult; Antibiotics, Antitubercular; Anticonvulsants; Antitubercular Agents; Erythema; Ethambutol; Exanthema; Female; Humans; Phenobarbital; Phenytoin; Pruritus; Rifampin	2008
A 96-well plate assay for CYP4503A induction using cryopreserved human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:11 Topics: Biological Assay; Carbamazepine; Cell Culture Techniques; Cell Membrane; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Pharmaceutical Preparations; Phenytoin; Reverse Transcriptase Polymerase Chain Reaction; Rifampin	2010
Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. The American journal of pathology, 2011, Volume: 178, Issue:1 Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 CYP3A; DNA Damage; DNA Repair; DNA-Binding Proteins; Gene Expression; Hepatocytes; Liver Failure, Acute; Liver Regeneration; Mice; Mice, SCID; Monocrotaline; Phenytoin; Protein Serine-Threonine Kinases; Rats; Rats, Inbred F344; Rifampin; Signal Transduction; Tumor Suppressor Proteins	2011
Multicenter study of voriconazole pharmacokinetics and therapeutic drug monitoring. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antifungal Agents; Australia; Drug Interactions; Drug Monitoring; Female; Glucocorticoids; Humans; Male; Middle Aged; Mitosporic Fungi; Mycoses; Nucleic Acid Synthesis Inhibitors; Phenytoin; Pyrimidines; Retrospective Studies; Rifampin; Treatment Outcome; Triazoles; Voltage-Gated Sodium Channel Blockers; Voriconazole	2012
Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Australia; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Female; Fungi; Humans; Logistic Models; Male; Metoclopramide; Middle Aged; Mycoses; Phenytoin; Ranitidine; Retrospective Studies; Rifampin; Triazoles	2012
Phenytoin-rifampin drug interaction in a hypoalbuminemic, renal failure patient: a complex clinical case. Pharmacotherapy, 2013, Volume: 33, Issue:6 Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypoalbuminemia; Male; Middle Aged; Phenytoin; Renal Dialysis; Rifampin; Seizures; Severity of Illness Index; Tuberculosis, Meningeal	2013
[In vivo evaluation of the metabolic ratio of CYP2C9 and CYP1A2 drug markers after administration of afobazole in comparison to standard inducers and inhibitors of cytochromes]. Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:11 Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Benzimidazoles; Ciprofloxacin; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Enzyme Inhibitors; Fluconazole; Male; Morpholines; Phenytoin; Rats; Rifampin	2013
HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance. Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:8 Topics: Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Liver Neoplasms; Phenytoin; Rifampin	2014
Understanding variability in posaconazole exposure using an integrated population pharmacokinetic analysis. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Adult; Anti-HIV Agents; Anticonvulsants; Antiemetics; Antifungal Agents; Biological Availability; Carbamates; Drug Interactions; Drug Therapy, Combination; Furans; Healthy Volunteers; Humans; Metoclopramide; Nucleic Acid Synthesis Inhibitors; Organophosphates; Phenytoin; Proton Pump Inhibitors; Rifampin; Sulfonamides; Triazoles	2014
Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for atorvastatin and its metabolites. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2015, Sep-18, Volume: 77 Topics: Area Under Curve; Atorvastatin; Cimetidine; Clarithromycin; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Models, Biological; Phenytoin; Rifampin	2015
Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:2 Topics: Biological Transport; Cells, Cultured; Coculture Techniques; Cytochrome P-450 Enzyme System; Half-Life; Hepatocytes; Humans; Phenobarbital; Phenytoin; Rifampin; RNA, Messenger; Xenobiotics	2016
Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:6 Topics: Administration, Oral; Carbamazepine; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Gastrointestinal Tract; Hepatocytes; Humans; Liver; Models, Biological; Phenobarbital; Phenytoin; Rifampin; RNA, Messenger	2016
The Impact of Strong Inducers on Direct Oral Anticoagulant Levels. The American journal of medicine, 2021, Volume: 134, Issue:10 Topics: Administration, Oral; Aged; Anticoagulants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Drug Interactions; Drug Monitoring; Female; Humans; Male; Phenobarbital; Phenytoin; Retrospective Studies; Rifampin	2021