Compounds > phenytoin

phenytoin and busulfan

phenytoin has been researched along with busulfan in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19905 (16.67)18.7374
1990's5 (16.67)18.2507
2000's6 (20.00)29.6817
2010's12 (40.00)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andricopulo, AD; Moda, TL; Montanari, CA1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lippmann, M1
Majewski, F1
Cahn, JY; Flesch, M; Paintaud, G; Tiberghien, P1
Fitzsimmons, WE; Ghalie, R; Kaizer, H1
Grigg, AP; Phillips, GL; Shepherd, JD1
Whitcomb, ME1
Brettner, A; Heitzman, ER; Woodin, WG1
Bewermeier, P; Hossfeld, DK; Krüger, W; Mross, K; Stockschläder, M; Zander, A1
Björkholm, M; Hassan, M; Lindgren, M; Oberg, G; Wallin, I1
Ashley, S; Atra, A; Calvagna, V; Pinkerton, CR; Shankar, AG; Shepherd, V; Souhami, RL; Whelan, JS1
Arranz, R; de La Cámara, R; Díaz, MA; Fernández-Rañada, JM; Figuera, A; Granados, E; Madero, L; Martín-Regueira, P; Steegmann, JL1
Bekassy, A; Hassan, M; Hassan, Z; Jonsson, EN; Karlsson, MO; Ljungman, P; Nilsson, C; Oberg, G; Ringden, O; Sandström, M1
Bechtel, T; Sherry, JH1
Bacigalupo, A; Buzyn, A; Cahn, JY; Carreras, E; Kröger, N; Puozzo, C; Sanz, G; Vernant, JP1
Bajwa, RP; Gross, TG; Pai, V; Skeens, M; Soni, S; Termuhlen, AM1
Floeter, AE; McCune, JS1
Akiyama, K; Enami, T; Fukaya, M; Ikeda, T; Kume, T; Shiki, I; Shino, M; Tatara, R1
Aljurf, M; Beitinjaneh, A; Bo-Subait, K; Bubalo, J; Cahn, JY; Cerny, J; Chhabra, S; Cumpston, A; Dupuis, LL; Krem, MM; Lazarus, HM; Marks, DI; Martin, PJ; Maziarz, RT; McCune, JS; Mineishi, S; Norkin, M; Pasquini, M; Prestidge, T; Wang, T1
Garrity, L; Hughes, K; Lane, A; Nelson, AS; Teusink-Cross, A1
Artul, T; Efrati, E; Henig, I; Kurnik, D; Lurie, Y; Nassar, L; Scherb, I; Yehudai-Ofir, D; Zuckerman, T1

Reviews

4 review(s) available for phenytoin and busulfan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Pulmonary reactions to drugs.
    The Medical clinics of North America, 1977, Volume: 61, Issue:6

    Topics: Adrenal Cortex Hormones; Aged; Aminoglycosides; Bleomycin; Busulfan; Contraceptives, Oral; Female; Foreign Bodies; Humans; Hypertension, Pulmonary; Lung; Lung Diseases; Mercury; Methotrexate; Nitrofurantoin; Paraquat; Phenytoin; Pneumonia; Polymyxins; Radiation Injuries; Sulfonamides

1977
[On certain embryopathies induced by teratogenic agents (author's transl].
    Monatsschrift fur Kinderheilkunde, 1977, Volume: 125, Issue:6

    Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany, West; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Lysergic Acid Diethylamide; Mercaptopurine; Nicotine; Phenytoin; Radiation Injuries; Teratogens; Thalidomide; Trimethadione; Warfarin

1977
Drug-induced lung disease.
    Chest, 1973, Volume: 63, Issue:3

    Topics: Anti-Bacterial Agents; Anticoagulants; Antihypertensive Agents; Bleomycin; Busulfan; Chlorpropamide; Cyclophosphamide; Hemorrhage; Heroin; Humans; Hydrochlorothiazide; Hypertension, Pulmonary; Inhalation; Leukemia, Lymphoid; Lipids; Lung; Lung Diseases; Methotrexate; Methysergide; Nitrofurantoin; Phenytoin; Pulmonary Edema

1973

Trials

2 trial(s) available for phenytoin and busulfan

ArticleYear
Influence on Busilvex pharmacokinetics of clonazepam compared to previous phenytoin historical data.
    Anticancer research, 2010, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Alkylating Agents; Anticonvulsants; Busulfan; Clonazepam; Cyclophosphamide; Drug Interactions; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Phenytoin; Prospective Studies; Seizures; Transplantation Conditioning; Young Adult

2010
Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019, Volume: 25, Issue:7

    Topics: Adolescent; Adult; Aged; Allografts; Anticonvulsants; Busulfan; Child; Child, Preschool; Cyclophosphamide; Disease-Free Survival; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Middle Aged; Phenytoin; Seizures; Survival Rate; Transplantation Conditioning

2019

Other Studies

24 other study(ies) available for phenytoin and busulfan

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
More on high-dose busulfan and seizure prophylaxis.
    Bone marrow transplantation, 1992, Volume: 9, Issue:2

    Topics: Adult; Bone Marrow Purging; Bone Marrow Transplantation; Busulfan; Epilepsy; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Phenytoin; Seizures

1992
The effect of hepatic enzyme inducers on busulfan neurotoxicity and myelotoxicity.
    Cancer chemotherapy and pharmacology, 1990, Volume: 27, Issue:3

    Topics: Animals; Aroclors; Bone Marrow; Busulfan; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Female; Liver; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Phenytoin

1990
Busulphan and phenytoin.
    Annals of internal medicine, 1989, Dec-15, Volume: 111, Issue:12

    Topics: Adult; Busulfan; Humans; Phenytoin; Seizures

1989
Pulmonary complications of drug therapy.
    Radiology, 1970, Volume: 96, Issue:1

    Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Busulfan; Child; Drug-Related Side Effects and Adverse Reactions; Female; Hexamethonium Compounds; Humans; Hydrochlorothiazide; Lung Diseases; Male; Mecamylamine; Methotrexate; Methysergide; Middle Aged; Nitrofurantoin; Penicillins; Phenytoin; Pleural Effusion; Pneumonia, Pneumocystis; Procainamide; Pulmonary Edema; Pulmonary Fibrosis; Radiography; Sulfadimethoxine

1970
Pharmacokinetics of undiluted or diluted high-dose etoposide with or without busulfan administered to patients with hematologic malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Chromatography, High Pressure Liquid; Drug Interactions; Etoposide; Female; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasms; Phenytoin; Therapeutic Equivalency

1994
Influence of prophylactic anticonvulsant therapy on high-dose busulphan kinetics.
    Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:3

    Topics: Adult; Bone Marrow Transplantation; Busulfan; Combined Modality Therapy; Diazepam; Drug Interactions; Female; Half-Life; Hodgkin Disease; Humans; Leukemia; Male; Middle Aged; Phenytoin; Seizures

1993
High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma.
    Bone marrow transplantation, 1997, Volume: 20, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Busulfan; Child; Child, Preschool; Clonazepam; Combined Modality Therapy; Contraindications; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Male; Melphalan; Neoplasm Metastasis; Phenytoin; Remission Induction; Sarcoma, Ewing; Seizures; Survival Analysis; Transplantation Conditioning; Treatment Outcome

1997
Hematopoietic cell transplantation in acute lymphoblastic leukemia: better long term event-free survival with conditioning regimens containing total body irradiation.
    Haematologica, 2000, Volume: 85, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Phenytoin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Whole-Body Irradiation

2000
Population pharmacokinetic analysis resulting in a tool for dose individualization of busulphan in bone marrow transplantation recipients.
    Bone marrow transplantation, 2001, Volume: 28, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Area Under Curve; Bayes Theorem; Body Fluid Compartments; Body Weight; Bone Marrow Transplantation; Busulfan; Child; Child, Preschool; Clonazepam; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Genetic Variation; Humans; Infant; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Phenytoin; Seizures; Transplantation Conditioning; User-Computer Interface; Whole-Body Irradiation

2001
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Anticonvulsants; Bone Marrow Transplantation; Busulfan; Epilepsy; Humans; Phenytoin; Seizures; Therapeutic Equivalency

2005
Levetiracetam for busulfan-induced seizure prophylaxis in children undergoing hematopoietic stem cell transplantation.
    Pediatric blood & cancer, 2012, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Busulfan; Child; Child, Preschool; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Levetiracetam; Phenytoin; Piracetam; Seizures; Transplantation Conditioning; Young Adult

2012
Levetiracetam for the prevention of busulfan-induced seizures in pediatric hematopoietic cell transplantation recipients.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2017, Volume: 23, Issue:5

    Topics: Adolescent; Anticonvulsants; Busulfan; Child; Child, Preschool; Female; Graft Rejection; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Infant; Levetiracetam; Male; Myeloablative Agonists; Phenytoin; Piracetam; Recurrence; Retrospective Studies; Seizures; Transplantation Conditioning; Young Adult

2017
Comparison of levetiracetam with phenytoin for the prevention of intravenous busulfan-induced seizures in hematopoietic cell transplantation recipients.
    Cancer chemotherapy and pharmacology, 2018, Volume: 82, Issue:4

    Topics: Administration, Intravenous; Anticonvulsants; Busulfan; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Levetiracetam; Male; Middle Aged; Phenytoin; Retrospective Studies; Seizures; Transplantation Conditioning; Treatment Outcome

2018
Comparison of levetiracetam versus phenytoin/fosphenytoin for busulfan seizure prophylaxis at a pediatric institution.
    Pediatric transplantation, 2021, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Busulfan; Child; Child, Preschool; Drug Administration Schedule; Female; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Infant; Levetiracetam; Male; Myeloablative Agonists; Phenytoin; Retrospective Studies; Seizures; Transplantation Conditioning; Treatment Outcome; Young Adult

2021
Decreased Systemic Busulfan Exposure After Oral Dosing With Concomitant Levetiracetam Compared With Phenytoin.
    Therapeutic drug monitoring, 2022, 06-01, Volume: 44, Issue:3

    Topics: Adult; Anticonvulsants; Busulfan; Hematopoietic Stem Cell Transplantation; Humans; Levetiracetam; Phenytoin; Retrospective Studies; Transplantation Conditioning

2022