pd 145065 and bq 123
pd 145065 has been researched along with bq 123 in 22 studies
Compound Research Comparison
| Studies (pd 145065) | Trials (pd 145065) | Recent Studies (post-2010) (pd 145065) | Studies (bq 123) | Trials (bq 123) | Recent Studies (post-2010) (bq 123) |
|---|---|---|---|---|---|
| 76 | 1 | 5 | 1,391 | 63 | 152 |
Protein Interaction Comparison
| Protein | Taxonomy | pd 145065 (IC50) | bq 123 (IC50) |
|---|---|---|---|
| Endothelin-1 receptor | Homo sapiens (human) | 0.017 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 0.014 |
Research
Studies (22)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (63.64) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Corder, R; Cristol, JP; Thiemermann, C; Vane, JR; Warner, TD; Wellings, RP | 2 |
| Gulati, A; Murlas, CG; Najmabadi, F; Singh, G | 1 |
| Battistini, B; Farthing, MJ; Fournier, A; O'Donnell, LJ; Vane, JR; Warner, TD | 1 |
| Battistini, B; Fournier, A; Vane, JR; Warner, TD | 1 |
| Allcock, GH; Vane, JR; Warner, TD | 2 |
| Allcock, GH; Battistini, B; Vane, JR; Warner, TD | 1 |
| Karaki, H; Miasiro, N; Paiva, AC | 1 |
| Allcock, GH; Warner, TD | 1 |
| D'Amico, M; Falciani, M; Filippelli, A; Palla, A; Rossi, F; Vacca, C | 1 |
| Alexiou, K; Baumann, G; Dschietzig, T; Laule, M; Schrör, K; Stangl, K | 1 |
| Kelso, EJ; McDermott, BJ; Scholfield, CN; Silke, B; Spiers, JP | 1 |
| Held, B; Pearson, HA; Pocock, JM | 1 |
| Armour, CL; Black, JL; Johnson, PR; McKay, KO | 1 |
| Calaghan, SC; White, E | 1 |
| Bartoli, E; Bergamasco, L; Castello, L; Letizia, C; Sainaghi, PP | 2 |
| Cupples, WA; Lau, C; Shi, Y | 1 |
| Groenendijk, BC; Hierck, BP; Lindken, R; Nieuwstadt, FT; Poelmann, RE; Stekelenburg-de Vos, S; Ursem, NT; Vennemann, P; Westerweel, J; Wladimiroff, JW | 1 |
| Castro-Chaves, P; Fontes-Carvalho, R; Leite-Moreira, AF; Pimentel-Nunes, P; Pintalhao, M | 1 |
| Rapoport, RM; Yoon, S; Zuccarello, M | 1 |
Other Studies
22 other study(ies) available for pd 145065 and bq 123
| Article | Year |
|---|---|
Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065.
Topics: Amino Acid Sequence; Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; In Vitro Techniques; Indoles; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Rats; Renal Circulation; Vasoconstriction | 1993 |
Endothelin-1 stimulates proliferation of normal airway epithelial cells.
Topics: Amino Acid Sequence; Animals; Cell Division; Cells, Cultured; DNA; Endothelins; Epithelial Cells; Epithelium; Glycopeptides; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Swine; Trachea | 1995 |
Characterization of endothelin (ET) receptors in the isolated gall bladder of the guinea-pig: evidence for an additional ET receptor subtype.
Topics: Amino Acid Sequence; Animals; Endothelins; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Oligopeptides; Peptides, Cyclic; Receptors, Endothelin; Viper Venoms | 1994 |
Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney.
Topics: Amino Acid Sequence; Anesthesia; Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Indoles; Indomethacin; Male; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Rats; Rats, Wistar; Renal Circulation; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1994 |
Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Receptors, Endothelin; Respiratory Physiological Phenomena; Respiratory System | 1994 |
Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065.
Topics: Amino Acid Sequence; Animals; Aorta, Thoracic; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligopeptides; Peptides, Cyclic; Rats; Rats, Wistar; Renal Circulation; Vasoconstriction | 1994 |
Endothelin ETA and ETB receptors mediate vasoconstriction and prostanoid release in the isolated kidney of the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Sequence; Animals; Dinoprost; Dinoprostone; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Kidney; Male; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Prostaglandins; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1993 |
Heterogeneous endothelin receptors mediate relaxation and contraction in the guinea-pig ileum.
Topics: Amino Acid Sequence; Animals; Apamin; Endothelin Receptor Antagonists; Endothelins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Isometric Contraction; Male; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Receptors, Endothelin; Sodium | 1995 |
Roles of endothelin receptors in the regional and systemic vascular responses to ET-1 in the anaesthetized ganglion-blocked rat: use of selective antagonists.
Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Endothelin Receptor Antagonists; Endothelins; Ganglionic Blockers; Hemodynamics; Hexamethonium; In Vitro Techniques; Male; Microspheres; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Endothelin; Regional Blood Flow; Vascular Resistance | 1995 |
Inhibition of ETB receptors limits the efficacy of nonselective endothelin antagonists in vivo.
Topics: Animals; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Male; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin | 1995 |
Distribution of endothelin-1-receptor subtypes in rat portal vein.
Topics: Animals; Endothelin Receptor Antagonists; Endothelins; Male; Muscle, Smooth, Vascular; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Portal Vein; Potassium Chloride; Rats; Rats, Wistar; Receptors, Endothelin; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1996 |
Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arteriosclerosis; Aspartic Acid Endopeptidases; Atrasentan; Coronary Circulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Endothelium, Vascular; Glycopeptides; In Vitro Techniques; Male; Metalloendopeptidases; Myocardial Contraction; Oligopeptides; Peptides, Cyclic; Protein Precursors; Pulmonary Embolism; Pyrrolidines; Rabbits; Thromboxane B2; Vasoconstriction | 1998 |
Stimulation of L-type Ca2+ current by the endothelin receptor A-selective antagonist, BQ-123 in ventricular cardiomyocytes isolated from the rabbit myocardium.
Topics: Action Potentials; Animals; Calcium Channels; Cell Separation; Dioxoles; Endothelin Receptor Antagonists; Heart Ventricles; Male; Oligopeptides; Patch-Clamp Techniques; Peptides, Cyclic; Rabbits; Stimulation, Chemical | 1998 |
Endothelin-1 inhibits voltage-sensitive Ca2+ channels in cultured rat cerebellar granule neurones via the ET-A receptor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Cerebellum; Dose-Response Relationship, Drug; Endothelin-1; Male; Nerve Tissue Proteins; Neurons; Oligopeptides; Patch-Clamp Techniques; Peptides, Cyclic; Potassium; Potassium Chloride; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Cholinergic; Receptors, Endothelin; Second Messenger Systems; Viper Venoms | 1998 |
Parasympathetic neurotransmission in rabbit isolated bronchus is modulated at prejunctional sites via endothelinB receptor stimulation.
Topics: Animals; Autoradiography; Bronchi; Electric Stimulation; Endothelin Receptor Antagonists; Endothelin-3; Evoked Potentials; Ganglia, Parasympathetic; In Vitro Techniques; Oligopeptides; Peptides, Cyclic; Rabbits; Receptor, Endothelin B; Receptors, Endothelin; Receptors, Neurotransmitter; Viper Venoms | 2000 |
Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle.
Topics: Angiotensin II; Animals; Endothelin-1; Endothelium; Female; Ferrets; Kinetics; Losartan; Male; Muscle Spindles; Myocardial Contraction; Octoxynol; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Saralasin | 2001 |
Pathways of glomerular toxicity of cyclosporine-A: an "in vitro" study.
Topics: Angiotensin I; Angiotensin II; Animals; Cyclosporine; Endothelin-1; Female; Kidney Glomerulus; Oligopeptides; Organ Culture Techniques; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Swine; Time Factors | 2005 |
Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Data Interpretation, Statistical; Endothelin B Receptor Antagonists; Endothelins; Enzyme Inhibitors; Homeostasis; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; Peptides, Cyclic; Rats; Rats, Wistar; Receptor, Endothelin B; Renal Circulation; Vascular Resistance | 2007 |
The endothelin-1 pathway and the development of cardiovascular defects in the haemodynamically challenged chicken embryo.
Topics: Animals; Aspartic Acid Endopeptidases; Blood Flow Velocity; Cardiac Output; Cardiovascular Abnormalities; Cells, Cultured; Chick Embryo; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Gene Expression Regulation, Developmental; Heart; Heart Rate; Hemodynamics; Laser-Doppler Flowmetry; Ligation; Metalloendopeptidases; Myocardium; Oligopeptides; Peptides, Cyclic; Piperidines; Receptors, Endothelin; RNA, Messenger; Signal Transduction; Time Factors; Veins; Ventricular Function; Yolk Sac | 2008 |
In vitro effect of cyclosporine-A on angiotensins secretion by glomerular cells.
Topics: Angiotensin I; Angiotensin II; Animals; Cyclosporine; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Female; Immunosuppressive Agents; Kidney Glomerulus; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Swine; Time Factors; Tissue Culture Techniques; Up-Regulation | 2008 |
Angiotensin II-induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart.
Topics: Acetophenones; Angiotensin II; Animals; Diastole; Dose-Response Relationship, Drug; Endocardium; Endothelin Receptor Antagonists; Endothelin-1; Endothelium; Enzyme Inhibitors; In Vitro Techniques; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Rabbits; Receptors, Endothelin | 2009 |
EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ.
Topics: Animals; Antihypertensive Agents; Basilar Artery; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Male; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstrictor Agents; Vasodilator Agents; Viper Venoms | 2012 |