osthol and warfarin
osthol has been researched along with warfarin in 387 studies
Research
Studies (387)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (1.55) | 18.7374 |
| 1990's | 14 (3.62) | 18.2507 |
| 2000's | 54 (13.95) | 29.6817 |
| 2010's | 237 (61.24) | 24.3611 |
| 2020's | 76 (19.64) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Huang, TF; Ko, FN; Liou, MJ; Teng, CM; Wu, TS | 2 |
| Gao, H; Miao, ML; Sha, ZF; Sun, WJ | 1 |
| Gao, H; Sha, ZF; Sun, WJ | 1 |
| Chen, ZC; Duan, XB; Liu, KR | 1 |
| Fujimura, H; Kozuka, M; Nakano, K; Nohara, T; Sawada, T; Tomimatsu, T; Yamahara, J | 1 |
| Li, L; Yang, L; Zhang, CL; Zhao, DK; Zhao, GS; Zhuang, FE | 1 |
| Li, L; Zhao, DK; Zhao, GS; Zhuang, FE | 1 |
| Huang, TF; Ko, FN; Lin, CH; Teng, CM; Wu, TS | 1 |
| Qin, LP; Wang, HB; Zhang, JQ | 1 |
| Chang, C; Chen, CC; Chen, CF; Hsieh, DJ; Hu, CP; Huang, RL; Huang, YL | 1 |
| Chen, CC; Chen, CF; Tsai, TH; Tsai, TR | 1 |
| Guh, JH; Ko, FN; Teng, CM; Wu, TS; Yu, SM | 1 |
| Cui, L; Huang, LF; Li, CY; Li, QN; Liang, NC; Lin, BY; Wu, T | 1 |
| Qin, LP; Zhang, HM; Zhang, WD | 1 |
| Qin, LP; Shi, HP; Zhang, JQ | 1 |
| Chen, CC; Chen, CF; Chen, J; Chiou, WF | 1 |
| Kobayashi, T; Okabe, S; Okamoto, T; Yoshida, S | 1 |
| Ojala, T; Törnquist, K; Vuorela, H; Vuorela, P | 1 |
| Chen, CC; Chen, CF; Chiou, WF; Huang, YL | 1 |
| Chen, CC; Chiang, HT; Li, HF; Lo, YK; Wu, SN | 1 |
| Hara, I; Li, XX; Matsumiya, T | 1 |
| Ido, Y; Kubo, M; Matsuda, H; Tomohiro, N | 1 |
| Cai, Q; Sha, M; Yang, S | 1 |
| Anand Solomon, K; Gopalakrishnan, G; Kashinath, V; Rajan, SS; Santhana Krishnan, VP | 1 |
| Hino, O; Kawasaki, T; Okamoto, T | 1 |
| Jin, LQ; Shen, LX; Xue, GP; Zhang, DS | 1 |
| Lian, Q | 1 |
| ANAND, KK; CHOPRA, IC; JAMWAL, KS | 1 |
| ANAND, KK; CHOPRA, IC; JAMWAL, KS; SETHI, OP | 1 |
| Dawei, C; Hui, X; Pingtian, D; Ruhua, Z; Zhenting, Y | 1 |
| Jin, JL; Lee, S; Lee, YY; Yun-Choi, HS | 1 |
| An, F; Mu, JX; Wang, SH; Zhang, DS; Zhang, L | 1 |
| Ito, Y; Wei, Y; Zhang, T | 1 |
| Chen, CS; Hsieh, CL; Hsieh, MT; Lin, CJ; Wang, WH; Wu, CR | 1 |
| MAO, YD; PARKS, LM | 1 |
| Li, A; Xie, J; Yuan, J; Zhou, F | 1 |
| Du, LJ; Shi, Y; Wang, WH | 1 |
| Kobayashi, T; Okamoto, T; Yoshida, S | 2 |
| Chang, CH; Chang, JK; Hsu, YL; Kuo, PL | 1 |
| Liu, S; Yu, Z; Zhao, J | 1 |
| Mi, H; Qu, LL; Ren, YL | 1 |
| Li, F; Li, Y; Liu, H; Meng, F; Xiong, Z | 1 |
| Liu, PX; Zhou, ZW | 1 |
| Abouchala, N; Al Tufail, M; Al-Shouli, S; Bogusz, MJ; Thestrup-Pedersen, K | 1 |
| Lian, Q; Liu, J; Wang, X; Zhang, W; Zhou, L | 1 |
| Gu, ZL; Song, F; Xie, ML; Xue, J; Zhang, KP; Zhu, LJ | 1 |
| Chou, SY; Hsu, CS; Wang, CC; Wang, KT; Wang, MC | 1 |
| Gu, ZL; Xie, ML; Zhang, Y; Zhu, LJ | 1 |
| Baba, K; Kamisako, T; Ogawa, H; Sasai, N | 1 |
| Bai, L; Ding, L; Qu, C; Zhang, H | 1 |
| Gu, Z; Xie, M; Xue, J; Zhang, Y | 1 |
| Li, C; Li, F; Liu, H; Liu, M; Lu, X; Xiong, Z | 1 |
| Li, TA; Weng, DX | 1 |
| Sun, XL; Wang, SW; Zhou, J | 2 |
| Gu, ZL; Sun, F; Xie, ML; Xue, J; Zhu, LJ | 1 |
| Luan, LB; Wu, YN | 1 |
| Guo, QM; Wang, Y; Yang, XW | 1 |
| Konstantopoulou, MA; Mazomenos, BE; Siskos, EP | 1 |
| Cheng, C; Wang, G; Yang, Z; Yao, J; Zhou, Z | 1 |
| Huang, WJ; Lin, TY; Lu, CW; Wang, SJ | 3 |
| Kuo, ML | 1 |
| Chiu, PR; Chu, YT; Hung, CH; Jong, YJ; Lee, MS; Lee, WT | 1 |
| Andres-Mach, M; Cisowski, W; Czuczwar, SJ; Glowniak, K; Luszczki, JJ; Mazol, I | 1 |
| Hu, M; Wang, K; Xu, H; Yuan, Z; Zhao, Z | 1 |
| An, R; Feng, S; Wang, X; You, L | 1 |
| Andres-Mach, M; Cisowski, W; Czuczwar, SJ; Glensk, M; Glowniak, K; Luszczki, JJ; Wojda, E | 1 |
| Chao, CC; Chou, CH; Kuo, YH; Leung, YM; Lin, CH; Tsou, YH; Wong, KL | 1 |
| Chang, CC; Chen, NQ; Chen, YC; Hung, LF; Liang, HJ; Liang, YC; Liu, DZ; Suk, FM; Wang, CK | 1 |
| He, L; Hou, X; Jiang, Q; Wang, S; Zhou, M | 1 |
| Chen, X; Hu, X; Jiang, Y; Liu, M; Ma, X; Mao, X; Pi, R; Zou, Y | 1 |
| Sun, F; Wang, HB; Xie, ML; Xue, J | 1 |
| Hu, X; Wang, P; Zhang, L; Zhang, LF | 1 |
| Bai, SF; Cao, B; Chen, H; Hou, XH; Liu, HQ; Wang, YZ | 1 |
| Chen, H; Fan, YJ; Li, CX; Shi, ZQ; Wang, CM; Zhou, W | 1 |
| Chen, D; Cheng, SD; Harris, SE; Holz, J; Hou, W; Li, TF; Sheu, TJ; Shi, Q; Tang, DZ; Wang, YJ; Zhang, M; Zhou, Q | 1 |
| Chang, CI; Chao, SW; Chen, CC; Hsu, FL; Huang, WJ; Hung, MF; Lee, SS; Lu, YL | 1 |
| Chou, CH; Lin, HY; Lin, JN; Lin, VC; Lin, YC; Tang, CH; Way, TD; Yu, CC | 1 |
| Chen, NH; Chen, XY; Hu, JF; Ji, HJ; Wang, YH; Zhou, R | 1 |
| Fujitani, T; Kaneko, M; Murakami, N; Tamura, S | 1 |
| Fei, Z; Li, X; Liu, WB; Lu, CT; Qu, Y; Sun, XL; Xie, KL; Zhou, J | 1 |
| Gu, T; Ma, C; Tang, Q; Wang, T; Yang, D | 1 |
| Cai, C; Chen, H; Fan, YJ; Fang, S; Guan, W; Li, YQ; Shi, ZQ; Wang, CM | 1 |
| Qi, Z; Wang, H; Xie, M; Xue, J; Zhang, Y | 1 |
| Chao, LK; Chen, J; Chien, SC; Dong, WC; Ho, CL; Hua, KF; Jeyashoke, N; Kuo, YH; Lee, SC; Liao, PC; Wang, EI | 1 |
| Chao, X; Chen, T; Dong, W; Fei, Z; Ji, X; Jiang, X; Liu, W; Qu, Y; Zhen, H; Zhou, J | 1 |
| Chen, KM; Ge, BF; Li, ZF; Ma, HP; Ming, LG; Zhai, YK; Zhou, J | 1 |
| Wang, H; Xie, M; Xue, J; Zhang, J; Zhang, Y | 1 |
| An, R; Li, Y; Wang, X; You, L | 1 |
| Eickmeier, E; Hamburger, M; Hering, S; Rueda, DC; Zaugg, J | 1 |
| Lian, Q; Liu, J; Liu, M; Liu, P; Mao, X; Pi, R; Xu, S; Ye, M; Yin, W | 1 |
| Qin, LH; Yu, H | 1 |
| Jiang, T; Li, S; Qu, D; Xu, X; Zhang, Y | 1 |
| Chao, X; Chen, T; Fei, Z; Huo, J; Liu, W; Luo, P; Qu, Y; Xie, K; Zhang, L | 1 |
| Du, R; Wang, HB; Xie, ML; Xue, J; Zhang, Y | 1 |
| Chen, KM; Cheng, GZ; Ma, HP; Ming, LG; Zhou, J | 1 |
| Cheng, ZH; Liu, J; Qian, RJ; Wang, FQ; Zeng, P; Zhou, J | 1 |
| Baburin, I; Ecker, GF; Hering, S; Kopp, B; Singhuber, J | 1 |
| Chou, CH; Ho, CT; Hung, CM; Kuo, DH; Su, YC; Way, TD | 1 |
| Chen, XF; Sheng, L; Wu, CY | 1 |
| Chen, R; Xie, ML; Xue, J | 1 |
| He, QL; Liu, XG; Ren, ZH; Sun, LB; Wang, L; Wei, M; Zhang, JJ | 1 |
| Guo, BF; Han, XH; Liu, S; Ye, YY | 2 |
| Dien, PH; Le Thuy, HT; Nhan, NT; Quang, DN | 1 |
| Chen, YC; Lee, WH; Liang, YC; Lin, HM; Lin, RJ; Lin, SY | 1 |
| He, X; He, Y; Lin, W; Qu, S; Wang, J; Zhang, X; Zhen, H | 1 |
| Cuong, NM; Fusi, F; Ha, le M; Saponara, S; Sgaragli, G | 1 |
| Ahn, YJ; Kim, JR; Shu, S; Wang, M; Wang, Z | 1 |
| Bai, KJ; Bien, MY; Chang, JH; Chen, CK; Chien, MH; Kao, SJ; Su, JL; Yang, SF; Yu, MC | 1 |
| Chen, KM; Han, GQ; Ming, LG; Wang, MG; Zhou, J; Zhu, RQ | 1 |
| Deng, S; Hou, J; Huang, SS; Liu, KX; Lv, X; Ma, XC; Shu, XH; Tian, Y; Wang, CY; Yao, JH; Zhang, BJ; Zhang, HL; Zhen, YH | 1 |
| Chen, XW; Chen, Y; He, QL; Li, MN; Mo, SL; Qin, J; Sun, LB; Wei, M; Zhang, JJ; Zhou, SF; Zou, XN | 1 |
| He, Y; Hu, B; Jiang, G; Li, Y; Liang, G; Liu, H; Wu, Y; Yao, F; Zhang, L; Zhang, Y | 1 |
| Hao, B; Liu, GL; Liu, SP; Wang, GX | 1 |
| Gong, Q; Li, F; Shi, J; Wang, L | 1 |
| Gu, ZL; Xie, ML; Xue, J; Zhong, W; Zhou, F | 1 |
| Chen, Y; Feng, XW; Qu, D; Xu, XM; Zhang, Y; Zhao, L | 1 |
| Chen, Y; He, QL; Liu, XG; Mo, SL; Nabar, NR; Sun, LB; Wei, M; Zhang, JJ; Zhou, SF; Zou, XN | 1 |
| Chen, W; Fu, Q; He, X; Liu, J; Shi, J; Wang, XM; Yang, HP | 1 |
| Chen, J; Feng, H; Huang, Y; Li, Y; Lu, P; Yang, L; Yao, L; Zhang, D; Zhu, D | 1 |
| Chan, W; Li, J | 1 |
| Cao, YL; Ding, DF; Duan, TL; Li, XF; Wei, SP; Zhan, HS; Zhang, XG | 1 |
| Feng, DQ; Ke, CH; Wang, ZC | 1 |
| Chen, XJ; Dong, HY; Hui, YP; Li, ZC; Ma, SR; Shi, Y; Sun, RH; Wang, YX; Xu, DQ; Zhang, B | 1 |
| Bi, X; Di, L; Kang, A; Shan, J; Yun, F; Zhao, X | 1 |
| Chang, YX; Deng, YR; Gao, XM; Guo, XR; He, J; Li, J; Ma, L; Zhang, BL; Zhang, L; Zhang, P; Zhang, QH | 1 |
| Lu, M; Ma, L; Qiu, M; Wang, Y; Zhang, S; Zheng, Y | 1 |
| Lu, M; Ma, L; Ma, X; Qiu, M; Zhang, S; Zheng, Y | 1 |
| Bi, S; Dong, W; Liu, H; Liu, Z; Ma, T; Wang, X; Zhang, W; Zhang, Z | 1 |
| Guo, B; Han, X; Liu, S; Sun, Z; Ye, Y | 1 |
| Bao, ND; Chen, XJ; Dong, HY; Hou, SJ; Jin, FG; Li, ZC; Liu, ML; Shi, Y; Sun, RH; Wang, YX; Xu, DQ; Zhang, B | 1 |
| Dong, PP; Lan, R; Liu, D; Sun, XC; Wang, G; Wang, XB; Wu, ZM; Xi, RG; Xin, XL | 1 |
| Bi, SH; Dong, WP; Ma, T; Pan, ZG; Wang, J; Wang, XW; Wang, XY; Yu, H; Zhang, WD | 1 |
| Hwang, TL; Liu, FC; Tsai, YF; Yu, HP | 1 |
| Guo, N; Liang, J; Shi, Q; Tang, X; Wei, J; Yu, L; Yuan, P | 1 |
| Fei, Z; Feng, F; Fu, LA; Gao, DK; Li, L; Yuan, H; Zhou, YF | 1 |
| Ding, DF; Du, GQ; Gong, H; Li, LH; Wang, HH; Zhan, HS | 1 |
| Guo, X; Huo, L; Jiang, Z; Lei, M; Wang, X | 1 |
| An, Y; Chen, FM; Gao, LN; Jin, Y; Lei, M; Li, B; Lu, H; Yang, H | 1 |
| Bei, YY; Chen, WL; Fan, YJ; Hu, XJ; Liu, Y; Wang, ZL; You, BG; Zhang, CG; Zhang, XN; Zhou, XF; Zhu, AJ; Zhu, QL | 1 |
| Huang, WJ; Liang, YC; Lin, RJ; Lin, SY; Liu, LY | 1 |
| Bai, CH; Li, S; Liu, DY; Shi, XF | 1 |
| Chang, X; Chen, Y; Liu, C; Liu, S; Su, R; Wang, Q; Xu, M; Yan, R; Yang, C; Yu, X; Zeng, W; Zhang, L; Zhang, S | 1 |
| Chen, KM; Cheng, K; Gao, YH; Ge, BF; Guo, XY; Ma, XN; Shi, WG; Yan, LJ; Zhen, P; Zhou, J | 1 |
| Chang, JM; Chao, LK; Chen, A; Chen, HL; Hua, KF; Ka, SM; Kao, TY; Tsai, YJ; Yang, SM; Yang, SS | 1 |
| Ding, H; Ding, Y; Hu, X; Lu, X; Ma, J | 1 |
| Chao, X; Dong, C; Jin, T; Song, X; Zhang, W; Zheng, G; Zhou, X | 1 |
| Chi, CC; Chiu, PT; Ho, SJ; Hsu, MJ; Hsu, YF; Huang, YH; Lee, CF; Li, YS; Ou, G; Wang, CH; Yang, HY | 1 |
| Cao, Y; Ding, D; Du, G; Li, L; Song, Y; Wei, S; Zhan, H | 1 |
| Li, FF; Li, YX; Lu, MD; Zhang, Z | 1 |
| Chen, R; Xie, M; Xue, J | 1 |
| Hu, Y; Kang, T; Liang, W; Ren, L; Sun, D; Wen, Q; Yang, J; Zhang, N; Zhao, D | 1 |
| Gao, P; Gao, Z; Li, H; Wen, Q; Xia, Y; Yang, J; Zhang, N; Zou, S | 1 |
| Chen, N; Han, N; Hu, J; Ji, H; Li, Z; Song, X | 1 |
| Bi, X; Di, L; Kang, A; Li, J; Shan, J; Yun, F; Zhao, X | 1 |
| Chen, JH; Huang, SS; Lin, C; Lu, DY; Tsai, CF; Yeh, WL | 1 |
| Alabi, OD; Braun, E; Gunnink, SM; Kerk, SA; Kuiper, BD; Louters, LL | 1 |
| Chen, Y; Liu, KX; Mo, LQ; Song, L; Tang, N; Wang, XB; Wu, GM; Zhang, YY; Zhou, J | 1 |
| Chang, TC; Chen, Y; Ho, CT; Hung, CM; Kao, JY; Lin, JC; Lin, YC; Liu, LC; Way, TD | 1 |
| Chan, YL; Chang, JM; Chao, LK; Chen, A; Chen, HL; Feng-Ling, Y; Hsu, YJ; Hua, KF; Ka, SM; Tsai, CL; Tsai, YJ; Tsai, YL; Wang, YF; Wu, SH; Yang, SM | 1 |
| Li, YX; Pan, C; Wang, HZ; Zhang, Z | 1 |
| Chen, WL; Jin, Y; Liu, Y; Yang, SD; Yuan, ZQ; Zhang, CG; Zhang, XN; Zhou, XF; Zhou, Y; Zhu, AJ; Zhu, QL | 1 |
| Deng, M; Wang, XL; Xie, ML; Xue, J; Zhang, Y; Zhao, X | 1 |
| Hosseinzadeh, L; Mohammadi-Motlagh, HR; Moieni-Arya, M; Mostafaie, A; Shokoohinia, Y | 1 |
| Chen, DR; Huang, SM; Tsai, CF; Wang, MY; Yeh, WL | 1 |
| Farooq, S; Hamid, A; Hussain, A; Koul, S; Qurishi, MA | 1 |
| Jeon, HJ; Jun, DW; Kim, EK; Lee, JS; Nam, HH; Saeed, WK | 1 |
| Gong, PT; Gu, YF; Li, H; Li, JH; Li, WC; Liu, C; Luo, WW; Wu, N; Zhang, XC | 1 |
| Cui, G; Gu, G; Li, J; Liu, L; Ma, B; Ouyang, P; Sun, J; Tang, B; Wei, P; Yang, X; Yao, D; Zhang, Q; Zhu, J | 1 |
| Chen, KM; Cheng, K; Ge, BF; Ma, HP; Ma, XN; Song, P; Zhen, P; Zhou, J | 1 |
| Dmoszyńska-Graniczka, M; Grabarska, A; Jarząb, A; Jeleniewicz, W; Kiełbus, M; Polberg, K; Sieniawska, E; Skalicka-Woźniak, K; Stepulak, A | 1 |
| Chen, X; Chen, Z; Gao, X; He, W; Lian, Q; Liu, A; Liu, J; Liu, P; Mao, X; Pi, R; Xu, S; Ye, J; Ye, M | 1 |
| Han, XH; Hu, QW; Lin, G; Liu, S; Lu, JG; Ma, J; Wang, CL; Xie, Y; Zhang, XH | 1 |
| Cui, Y; Shang, X; Wang, XL; Xie, ML; Zhang, Y; Zhao, X | 1 |
| Huang, WJ; Lee, WH; Li, YN; Liang, YC; Lin, RJ; Lin, SY; Wu, HH | 1 |
| Wu, SJ | 1 |
| Chen, CN; Hsu, CY; Hua, KT; Huang, CY; Liao, CH; Pai, JT; Weng, MS; Yu, SY | 1 |
| Jiang, G; Liang, G; Liu, H; Wang, F; Wu, Y; Xu, H; Yao, F; Yu, X; Zhang, L | 1 |
| Deng, Y; Guo, X; Li, F; Li, N; Lu, Y; Xiong, Z; Zhao, L | 1 |
| Cieślińska, A; Jarmołowska, B; Karolina Kordulewska, N; Kostyra, E; Matysiewicz, M | 1 |
| Chen, MW; Chen, TJ; Li, Y; Ning, JJ; Ren, H; Yang, T; Zhang, S; Zhou, YF | 1 |
| Fu, Q; Gao, Z; Lin, K; Shang, B; Sui, S | 1 |
| Chien, MH; Hsiao, M; Lee, LM; Lee, WJ; Tan, P; Wen, YC; Yang, SF | 1 |
| Chiu, YT; Fu, SL; Huang, YT; Liu, YW | 1 |
| Jia, M; Li, HQ; Li, YM; Qin, LP; Rahman, K; Wen, X; Zhang, ND; Zhang, QY | 1 |
| Cao, Y; Ding, D; Du, G; Li, L; Song, Y; Wang, X; Wei, L; Xu, Q; Zhan, H; Zheng, Y | 1 |
| Hu, Y; Jiao, Y; Kong, L; Li, S; Yang, J; Yao, Y | 1 |
| Jiao, Y; Kong, L; Song, J; Tao, Z; Xia, Y; Yang, J; Yao, Y; You, Z | 1 |
| Liu, Z; Mao, X; Wang, Z; Zhou, H; Zhou, Y | 1 |
| Gong, D; Liu, H; Qi, L; Shi, H; Xue, X | 1 |
| Chen, CY; Chung, PJ; Hwang, TL; Kuo, LM; Leu, YL; Tsai, YF; Yu, HP | 1 |
| Qi, ZG; Xie, ML; Zhao, X; Zhong, W | 1 |
| Fang, Z; Liu, X; Lu, W; Pan, Z; Zhang, Y | 1 |
| Fan, J; Gan, M; Lv, S; Mao, H; Pan, C; Wang, G; Yan, M; Zhang, Y | 1 |
| Gao, Z; Jiao, Y; Kong, L; Li, S; Liang, W; Tao, Z; Yan, Y; Yang, J; Yao, Y | 1 |
| Dou, PC; Duan, J; Liu, H; Tan, SY; Yang, Y | 1 |
| Gao, C; Han, Y; Xu, H; Yan, M; Zhang, M | 1 |
| Chen, KM; Gao, YH; Ma, XN; Ren, XM; Shi, WG; Yan, LJ; Zhou, J | 1 |
| Hao, Y; Liu, Y | 1 |
| Acevedo, AC; Amorim, BR; Costa, CR; De Luca Canto, G; de Magalhães, P; Guerra, EN | 1 |
| Ding, D; Li, K; Zhang, M | 1 |
| Chen, JR; Jia, XH; Li, YJ; Wang, H; Wang, JY | 1 |
| Gao, R; Hao, Y; He, G; Shi, J; Tang, Y | 1 |
| Jiao, Y; Kong, L; Li, S; Tao, Z; Yan, Y; Yang, J; Yao, Y | 1 |
| Beom Kim, S; Hee Jo, Y; Hwang, BY; Joo Choi, H; Kim, C; Kyeong Lee, M; Kyum Kim, S; Liu, Q | 1 |
| Gegen, T; He, Q; Lan, L; Shi, H; Tang, K; Tang, M; Tang, ZX; Wang, CM; Wang, ZL; Wu, GY; Yang, NN; Yang, Y; Yu, G; Yuan, XL; Zhu, C | 1 |
| Bi, Z; Cao, Y; Chen, Y; Liu, T; Liu, Z; Lu, Y; Peng, Y; Shan, H; Wang, L; Yang, L; Zhou, Y | 1 |
| Liu, J; Xu, R; Zhao, X | 1 |
| Cao, Y; Chen, M; Dai, G; Ding, D; Du, G; Han, D; He, J; Hu, H; Wang, X; Zhao, Y; Zheng, Y | 1 |
| Jin, Y; Li, JX; Liu, DH; Meng, S; Shi, W; Wang, P; Zhang, C; Zhang, XW | 1 |
| Fang, ZQ; Liang, LL; Liu, XM; Lu, WL; Pan, ZQ; Zhang, YY | 1 |
| Gao, Z; Jiao, Y; Kong, L; Li, S; Song, J; Tao, Z; Xia, Y; Yan, Y; Yang, J; Yao, Y; Zhang, G | 1 |
| Hou, TT; Jia, M; Li, Y; Qin, LP; Xin, HL; Xu, HT; Zhang, ND; Zhang, QY | 1 |
| Gao, H; Jing, T; Luo, Y; Xin, Q; Yuan, M; Zhang, G | 1 |
| Chan, CW; Lai, YM; Leung, WN; Li, G; Zhang, Z | 1 |
| Wang, JQ; Wang, QQ; Yu, X; Zhang, MZ; Zhang, RR; Zhang, WH; Zhang, YL | 1 |
| Jiang, G; Li, M; Li, W; Liu, J; Liu, L; Owusu, L; Ren, B; Tang, Y; Zhang, J | 1 |
| Chen, Y; Huang, J; Li, X; Shi, Q; Shu, B; Tang, D; Wang, L; Wang, Y; Xue, C; Zhao, D; Zhao, Y | 1 |
| Li, HY; Li, SH; Lin, Y; Yan, YH; Yang, JX | 1 |
| Cieślińska, A; Fiedorowicz, E; Jarmołowska, B; Kordulewska, NK; Kostyra, E | 1 |
| Dai, X; Guo, S; Qiao, Y; Shi, X; Wan, G; Wang, R; Wu, Z; Yang, S | 1 |
| Cieślińska, A; Fiedorowicz, E; Kordulewska, NK; Kostyra, E; Matysiewicz, M; Sienkiewicz-Szłapka, E | 1 |
| Chen, L; Chen, R; Cheng, ZQ; Liu, JC; Qin, Q; Wang, F; Xie, ML | 1 |
| Deng, X; Li, G; Liu, B; Liu, S; Luo, ZQ; Qiu, J; Wang, J; Yang, Z; Zhang, B; Zhou, X | 1 |
| Fan, HY; Li, P; Qi, D; Qu, HL; Wang, L; Wang, XK; Yu, C; Zhang, YJ | 1 |
| Li, R; Song, Y; Wen, A; Wu, Y; Yao, M; Zhao, C | 1 |
| Dai, X; Guo, S; Qiao, Y; Shi, X; Wang, R; Wu, Z; Yang, S; Yin, Q | 1 |
| Fu, Y; Guo, C; He, X; Kou, J; Liu, W; Shi, M; Wang, J; Wei, Z; Yang, Z; Zhou, E | 1 |
| Chen, X; Feng, H; Lu, JJ; Pei, L; Wang, Y | 1 |
| Shen, Y; Wang, Z | 1 |
| Du, J; Gong, P; Jiang, GQ; Li, HM; Lin, ZK; Liu, J; Luo, HF; Ning, Z; Tan, G; Wang, ZY; Xin, Y | 1 |
| Wang, F; Xie, M; Zhao, X; Zhou, R; Zhu, Z | 1 |
| Fu, Q; Guan, J; Lv, T; Qu, S; Wei, X; Yuan, Y | 1 |
| Gonzalez, FJ; Li, F; Li, XM; Liu, HN; Zhao, Q | 1 |
| Han, MA; Kim, S; Kwon, TK; Min, KJ; Park, JW | 1 |
| Chen, XY; Liu, YH; Luo, DD; Su, ZR; Sun, CY; Wang, Q; Wang, XF; Zhan, JY; Zhang, ZB; Zheng, YF | 1 |
| Hu, S; Huang, CH; Huang, SC; Huang, WC; Liao, PC; Wu, SJ | 1 |
| Cao, MH; He, QL; Li, MN; Sun, LB; Wang, YM; Wei, M; Wu, HX; Xu, H | 1 |
| Grabarska, A; Jarząb, A; Skalicka-Woźniak, K; Stepulak, A | 1 |
| Cai, Y; Chen, H; Li, H; Lin, YD; Sun, W; Zhang, XX | 1 |
| Chai, D; Du, J; Guan, SX; Huang, XW; Jiang, YY; Li, DD; Sun, Y; Zhang, HY | 1 |
| Wang, Z | 1 |
| Chan, CW; Kong, SK; Leung, WN; Li, G; Lu, X; Wong, YM; Zhang, ZR | 1 |
| Gao, Y; Li, WN; Li, YL; Li, YQ; Qian, ZQ; Wang, JY; Yang, DL | 1 |
| Gao, P; Li, HY; Song, J; Tao, ZY; Yan, YH; Yang, JX | 1 |
| Li, Y; Qian, Z; Wang, Y; Yang, D; Zhu, L | 1 |
| Dong, Z; Fei, D; He, X; Jin, F; Jin, Y; Li, B; Sun, J; Yuan, L; Zhang, Y | 1 |
| Dong, Z; Huang, T | 1 |
| Cao, YB; Gu, LQ; Han, B; Jiang, YY; Li, LP; Shen, CY; Wang, XJ; Yang, QL; Yu, YQ; Zhang, JY; Zhang, LL | 1 |
| Li, L; Li, Q; Liu, L; Mao, J; Tang, Q; Wang, Q; Wu, G; Zhang, Z; Zhao, B | 1 |
| Kong, L; Liang, W; Lin, Y; Song, J; Wang, L; Xia, Y; Yan, Y; Yang, J; Yao, Y | 1 |
| He, W; Liu, F; Song, X; Xie, K; Zhang, X; Zhu, X | 1 |
| Chen, D; Jin, H; Jin, X; Luo, C; Mi, M; Tong, P; Wang, P; Xu, T; Ying, J; Zhang, L; Zhang, S | 1 |
| Gao, XC; Tong, Y | 1 |
| Li, L; Li, Y; Shi, F; Wang, L; Yang, D | 1 |
| Guz, M; Hałasa, M; Jarząb, A; Polberg, K; Skalicka-Woźniak, K; Smok-Kalwat, J; Stepulak, A; Łuszczki, J | 1 |
| Bazvandi, L; Bhattacharyya, P; Bishayee, A; Chow, N; Farooqi, AA; Farzaei, MH; Hosseinzadeh, L; Jafari, F; Mohammadi, Z; Nabavi, SM; Shokoohinia, Y; Yerer, MB | 1 |
| Chang, DC; Chen, MK; Chuang, YC; Hsi, YT; Hsieh, MJ; Lin, CC; Lin, SH; Liu, PY; Lo, YS | 1 |
| Bao, Y; Liu, F; Meng, X; Wang, F; Wang, H; Xie, G; Yang, J | 1 |
| Badr, AM; Khairy, H; Marie, MS; Saleh, H | 1 |
| Chikazawa, M; Sato, R | 1 |
| Li, T; Li, Z; Liu, L; Liu, X; Long, F; Lv, Y; Zhan, Q; Zhu, X | 1 |
| Qin, L; Shou, D; Wang, N; Wang, X; Wu, R; Xin, H; Xu, P; Zhang, Q; Zhang, Y | 1 |
| Liu, X; Xu, X; Zhang, Y | 1 |
| He, G; Liu, K; Ou, C; Wang, L; Yang, Y; Yao, L | 1 |
| Bhatti, R; Kesavan, A; Mannan, R; Singh, D; Singh, G; Singh, P | 1 |
| Hou, J; Huang, T; Liu, Z; Xu, R; Yang, M | 1 |
| Chen, J; Fang, W; Gao, S; Gui, Y; Guo, Y; Hu, R; Lu, W; Nie, X; Shen, Q; Sun, C; Wang, B | 1 |
| Dong, Y; Liu, S; Lu, S; Sha, N; Shi, Q; Shu, B; Tang, D; Wang, Q; Wang, Y; Zhang, H; Zhang, Y; Zhao, D; Zhao, Y | 1 |
| Liang, X; Lin, Y; Shi, Y; Yang, J; Yao, Y | 1 |
| Che, Y; Li, J; Li, Z; Wang, S; Yan, Y; Zou, K; Zou, L | 1 |
| Bao, X; Chen, X; Jin, Y; Ju, X; Li, L; Li, W; Liang, G; Qian, J; Wu, W; Xiao, Z; Zheng, S; Zhu, W | 1 |
| Gao, H; Liu, J; Qiu, C; Wang, B; Wang, X; Yang, L; Zhang, L; Zhang, Q; Zhang, Z; Zheng, X | 1 |
| Gao, Q; Qi, H; Sun, LL; Sun, XY; Wang, GX; Wang, K; Wei, NN | 1 |
| Liu, YQ; Peng, JM; Wang, DY; Wu, AL; Ye, JL; Yu, YJ | 1 |
| Gao, Y; Gong, Y; Jia, T; Li, G; Li, L; Li, S; Liang, S; Liu, H; Liu, S; Ouyang, S; Shi, L; Wu, B; Xu, H; Yang, R; Yi, Z; Yuan, H; Zhang, C; Zhao, S; Zou, L | 1 |
| Banday, JA; Farooq, S; Hamid, A; Hussain, A; Koul, S; Nazir, M; Qurishi, MA | 1 |
| Cai, Y; Li, H; Sun, W; Zhang, XX; Zhou, WB | 1 |
| Che, J; Shi, G; Tang, J; Wang, Y; Zhao, H | 1 |
| Hirose-Sugiura, T; Kato, Y; Makino, T; Matsuo, H; Sakai, R; Suzuki, H; Takada, T; Tashiro, Y | 1 |
| Chen, Y; Kong, L; Wang, Y; Yang, J; Yao, Y | 1 |
| Dai, X; Guo, G; Liang, G; Wang, O; Xiang, Y; Yin, C; Zhang, X; Zhang, Y; Zhao, C | 1 |
| Xie, M; Xue, J; Zhao, X | 1 |
| Chen, R; Geng, D; Wang, X; Wang, Y; Yao, R; Zhen, F; Zhou, Y | 1 |
| Chuang, LY; Guh, JY; Huang, JS; Hwang, JY; Kan, WC; Yang, YL; Ye, YL | 1 |
| Kong, L; Liang, X; Lin, Y; Ni, Y; Shi, Y; Wu, Y; Xiao, H; Yang, J; Yao, Y | 1 |
| Li, H; Li, L; Mo, Z; Wu, Y; Yu, H | 1 |
| Fu, X; Hong, C | 1 |
| Chen, J; Lu, H; Shen, Z | 1 |
| Deng, X; Guo, Y; Liu, S; Liu, X; Niu, X; Wang, J; Wang, Y; Zhou, Y | 1 |
| Chen, D; Fan, H; Gao, Z; Ji, K; Li, X; Liang, H; Liu, P; Liu, Y; Wang, X; Wu, J; Zhao, F | 1 |
| Du, M; Li, YZ; Lu, Y; Sun, Z; Xu, HR; Zeng, CQ | 1 |
| Liang, X; Lin, Y; Shi, Y; Xiao, H; Yang, J; Yao, Y | 1 |
| Chwała, B; Cieślińska, A; Fiedorowicz, E; Jarmołowska, B; Kordulewska, NK; Kostyra, E; Moszyńska, M | 1 |
| Gong, D; Hu, X; Liu, Y; Pan, J; Wang, R; Zhang, G | 1 |
| Li, X; Liu, Z; Su, J; Zhang, F | 1 |
| Kong, L; Liang, X; Ni, Y; Xia, Y; Yang, J; Yao, Y | 1 |
| Bjørklund, G; Chirumbolo, S | 1 |
| Chen, L; Gan, N; Shao, B; Yang, D; Yu, Y; Zheng, X | 1 |
| Gao, Y; Le Zou, T; Liu, YB; Ren, T; Shao, ZY; Wang, HF; Wang, XA; Yuan, RY; Zhang, YJ | 1 |
| Qu, Y; Sun, X; Wang, G; Wang, K | 1 |
| Cao, T; Chang, Z; Chu, Q; Liu, Y; Lu, J; Zhang, Y; Zhu, Y | 1 |
| Hu, J; Li, X; Mo, Y; Qiu, Z; Rao, H; Tian, X; Wu, D; Wu, Y; Zheng, G | 1 |
| Lim, W; Park, S; Park, W; Song, G | 1 |
| Chang, CL; Chang, WT; Chern, CM; Chiou, WF; Liou, KT; Shen, YC; Wang, YH; Yao, CH; Zhou, H | 1 |
| Fu, S; Hua, L; Li, YL; Li, YQ; Lv, JY; Wu, YT; Yang, DL; Yue, Y; Zhu, L | 1 |
| Cao, ZW; Gu, ZW; Jin, MZ; Ren, YY; Yang, J; Zhu, XJ | 1 |
| Duan, YY; Guo, HJ; Guo, J; Guo, XL; Huang, DY; Li, Z; Yang, Q; You, JM; Zou, ZL | 1 |
| An, DR; Chen, YH; Guo, DS; Liu, Y; Lu, MH; Shang, CM; Yue, JY; Zhao, MM | 1 |
| Hu, X; Huang, W; Xia, CH; Xiong, YQ | 1 |
| Jiang, Q; Li, JJ; Li, XM; Lu, C; Tao, SY; Yan, B; Zhang, QY | 1 |
| Dan, Y; Guo, J; Li, G; Liang, S; Peng, H; Sheng, X; Wu, B; Xu, Z; Zhang, Y | 1 |
| Huang, W; Huang, X; Li, H; Liang, J; Wang, X; Xu, Y; Zhou, J | 1 |
| Ashrafizadeh, M; Johnston, TP; Mohammadinejad, R; Sahebkar, A; Samarghandian, S; Yaribeygi, H | 1 |
| Guo, Y; Huang, G; Ma, Y; Pan, Y; Si, Y; Sun, J; Tu, P; Wang, L; Xu, G; Zheng, S | 1 |
| Chen, Y; Gao, J; Gao, Y; Huang, Y; Liu, P; Yang, Q; Yu, H; Zhang, C; Zhu, D | 1 |
| Cui, H; Fan, D; Huang, Y; Kong, L; Lü, C; Sun, M; Wang, Y; Zhai, H | 1 |
| Deng, Y; Kong, L; Li, H; Li, W; Li, Y; Liang, X; Lin, Y; Ni, Y; Wang, Y; Wu, Y; Xiao, H; Yang, J | 1 |
| Su, YR; Wang, XX; Yang, F; Yuan, WX; Zhang, J; Zhang, LN | 1 |
| Cao, H; Niu, Z; Ren, HH; Shi, L; Yang, YX; Yao, L | 1 |
| Cheng, L; Fu, M; Ju, RJ; Kong, L; Li, HY; Li, XT; Liu, JJ; Ni, YN; Wang, YY; Wu, YT; Xiao, HH; Yang, JX; Yao, YJ | 1 |
| Bądziul, D; Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Rzeski, W; Skalicka-Woźniak, K; Sumorek-Wiadro, J; Wertel, I; Zając, A | 1 |
| Che, P; Gen, Y; Guo, Y; Hou, E; Liu, Z; Ma, N; Yang, R | 1 |
| Hussain, G; Rasul, A; Riaz, A; Sarfraz, I; Sarker, SD; Selamoglu, Z; Shafiq, N; Shah, MA; Zafar, S; Zahoor, MK | 1 |
| Chen, Z; Guan, G; Guo, J; Li, Y; Liu, G; Liu, W; Luo, J; Ni, J; Qu, Z; Ren, Q; Tan, Y; Wang, J; Wu, Z; Xu, X; Yin, H | 1 |
| Aktar, S; Caruso, F; Davis, M; Gahn, C; Hefter Feuss, E; Roman-Holba, S; Rossi, M; Wen, K | 1 |
| Sun, D; Ye, J; Yu, J; Yu, Y | 1 |
| Bae, H; Lee, JY; Lim, W; Song, G; Song, J | 1 |
| Huang, W; Kong, L; Li, X; Mohammadtursun, N; Wang, G; Wang, L; Yang, Q | 1 |
| Cheng, L; Deng, Y; Ju, RJ; Kong, L; Li, HY; Li, WY; Li, XT; Li, Y; Liang, XC; Lin, Y; Ni, YN; Shi, Y; Wu, YT; Xiao, HH; Yang, JX | 1 |
| Hao, M; Li, S; Li, T; Lv, M; Ren, Z; Xu, H | 1 |
| Fan, Y; Guo, L; Guo, T; Sun, H; Wei, J; Xu, C; Zhao, S | 1 |
| Bhatti, R; Garg, S; Kaur, A; Singh, L | 1 |
| Chen, X; Gong, Q; Li, F; Liu, Y; Shi, J | 1 |
| Li, YZ; Sun, Z; Xu, HR; Zeng, CQ; Zhang, QG | 1 |
| Dou, X; Huang, C; Li, K; Shu, F; Tang, H; Zhao, Y | 1 |
| Fan, K; Guo, J; Li, H; Sun, N; Sun, P; Sun, Y; Wan, S; Xu, Y; Yin, W; Zheng, X | 1 |
| Gan, H; Ma, L; Sang, D; Su, L; Wang, R; Wu, Y; Yang, G; Zhang, L; Zhou, J | 1 |
| Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Rzeski, W; Skalicka-Woźniak, K; Sumorek-Wiadro, J; Zając, A | 1 |
| Abel, PW; Cao, Z; Casale, TB; Huang, YG; Huo, YW; Jiang, H; Jiao, HZ; Kuang, X; Li, Y; Panettieri, RA; Tu, Y; Wang, S; Wei, T; Wolff, DW; Xie, Y; Zou, X | 1 |
| Feng, Y; Li, Q; Qiu, D; Yang, L; Zhang, Y | 1 |
| Chen, X; Fu, M; Guan, X; Huangfu, M; Li, X; Liu, H; Qin, J; Wang, J; Wei, R; Yu, D | 1 |
| Florek-Łuszczki, M; Grabarska, A; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
| Hao, J; Hao, Q; Hou, X; Song, Y; Wang, J; Wang, X | 1 |
| Arellano-Buendía, AS; García-Arroyo, FE; Gonzaga-Sánchez, G; Johnson, RJ; Lanaspa, MA; Manterola-Romero, L; Muñoz-Jiménez, I; Osorio-Alonso, H; Pedraza-Chaverri, J; Roncal-Jiménez, CA; Sánchez-Lozada, LG; Tapia, E | 1 |
| Li, T; Lv, M; Ren, Z; Sun, Z; Xu, H; Zhang, S | 1 |
| Dai, X; Liao, Y; Sheng, M; Shi, X; Wu, X | 1 |
| Chen, L; Chen, M; Dou, L; Gao, J; Shao, B; Yang, D; Yang, S; Yu, Y | 1 |
| Hua, L; Li, YL; Qian, ZQ; Yang, DL; Yue, Y; Zhu, L | 1 |
| Chen, H; Du, X; Hu, Q; Jiang, Q; Shen, J; Wei, J; Yan, S; Yin, M | 1 |
| Chen, YQ; Han, XH; Liu, S; Luo, ZY; Ma, J; Song, HY; Wang, JY; Zhou, Y; Zhou, ZY | 1 |
| Nadezhdin, KD; Neuberger, A; Sobolevsky, AI; Zakharian, E | 1 |
| Liu, X; Sun, XY | 1 |
| Chen, J; Chen, Y; Fang, L; Gao, H; Lu, Y; Lv, R; Lyu, L; Wang, P; Wang, W; Xu, F; Yan, T; Zuo, A | 1 |
| Chen, JM; Fang, JS; Huang, MJ; Li, WR; Liang, Y; Lin, MJ; Liu, JM; Ma, CR; Wang, Q; Wu, FC; Yu, WQ; Zuo, X | 1 |
| Duan, P; Huang, M; Huang, Q; Mei, J; Pan, L; Wang, D; Zhang, X | 1 |
| Fu, M; Li, Y; Niu, Z; Ren, H; Yao, L; Zhang, X | 1 |
| Liu, N; Sun, N; Tian, H; Wang, S; Zhang, G | 1 |
| Jarmołowska, B; Kordulewska, NK; Rozmus, D; Topa, J | 1 |
| Jarmołowska, B; Kordulewska, NK; Stryiński, R; Topa, J | 1 |
| Cui, J; Huang, J; Huang, W; Huang, Y; Ma, L; Wu, Y; Zhu, F | 1 |
| Chou, TC; Peng, KY | 1 |
| Lv, M; Ren, Z; Xu, H | 1 |
| Böleken, ME; Çelik, H; Dörterler, ME; Günendi, T; Kocaman, OH; Koyuncu, I; Yumuşak, N | 1 |
| Fan, K; Huang, H; Xie, ML; Xie, T; Zhao, Y; Zhu, ZY | 1 |
| Chen, X; Dou, T; Guan, X; Han, M; Huangfu, M; Li, X; Liu, G; Liu, Y; Wang, J; Wei, R; Yu, D; Zhou, L | 1 |
| Hao, M; Li, H; Lv, M; Xu, H; Xu, J; Zhou, L | 1 |
| Lu, JH; Wang, WY; Wu, B; Yang, XQ; Zhu, XF | 1 |
| Chen, MY; Cheng, J; Chuang, TN; Lin, WY; Liu, CH; Liu, HP | 1 |
| Eberhardt, MM; Leffler, A; Pantke, S; Rudolf, D; Torres, KV | 1 |
| Jin, SY; Rao, DC; Wan, GY; Wang, FF; Yang, PM; Zhou, YM | 1 |
| Huang, H; Xie, ML; Xie, T; Xue, J | 1 |
| Han, D; Jiang, X; Li, F; Li, P; Liu, J; Lu, Z; Yu, J; Zhang, Q | 1 |
| Chu, W; Fu, Y; Ma, Z; Peng, L; Wang, P | 1 |
| Deng, X; Han, L; Li, X; Shi, Z; Wu, E; Zhang, C | 1 |
| Chang, LZ; Chang, MS; Chen, MY; Cheng, J; Chuang, TN; Hsieh, WT; Kuo, YH; Lin, WY; Liu, CH; Liu, HP; Wu, BT; Xiao, YR | 1 |
| Guo, DA; He, X; Li, J; Ma, X; Nie, M; Wang, C; Wang, M; Wei, X; Wu, S; Yao, C | 1 |
| Cheng, Y; Kang, J; Zhang, L; Zhou, X | 1 |
| Fan, Z; Shen, X; Wang, P; Wang, Y; Wei, W; Yan, X; Yang, C; Zhou, Z | 1 |
| Chen, R; Guo, Z; Hou, H; Yang, Y | 1 |
| Hayashi, T; Kamauchi, H; Kiba, Y; Kitamura, M; Seki, T; Suzuki, R; Tanikawa, T | 1 |
Reviews
11 review(s) available for osthol and warfarin
| Article | Year |
|---|---|
[Advances in the study of chemical constituents and pharmacological actions of Cnidium monnieri (L.) Cusson].
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cnidium; Coumarins; Drugs, Chinese Herbal; Plants, Medicinal; Trace Elements; Vasodilator Agents | 2003 |
Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Coumarins; Furocoumarins; Glycyrrhizic Acid; Hepatitis C, Chronic; Interferons; Mice; Structure-Activity Relationship | 2005 |
[Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri].
Topics: Antineoplastic Agents, Phytogenic; Cnidium; Coumarins; Drugs, Chinese Herbal; Furocoumarins; Molecular Structure | 2005 |
Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties.
Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Antifungal Agents; Antipruritics; Bone Density Conservation Agents; Cnidium; Coumarins; Female; Humans; Male; Phytotherapy; Sexual Dysfunction, Physiological; Skin Diseases; Structure-Activity Relationship | 2015 |
Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review.
Topics: Aloe; Cell Differentiation; Cell Proliferation; Centella; Coumarins; Epimedium; Flavonoids; Hesperidin; Humans; Mannans; Morinda; Osteogenesis; Periodontal Ligament; Plant Extracts; Triterpenes; Zanthoxylum | 2016 |
Pharmacological features of osthole.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cnidium; Coumarins; Humans; Neuroprotective Agents; Plant Extracts | 2017 |
Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Coumarins; Humans; Neoplasms; Signal Transduction | 2018 |
Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms.
Topics: Antineoplastic Agents; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2020 |
Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Biological Products; Cnidium; Coumarins; Humans | 2021 |
Osthole: Synthesis, Structural Modifications, and Biological Properties.
Topics: Cnidium; Coumarins | 2022 |
Effects of osthole on osteoporotic rats: a systematic review and meta-analysis.
Topics: Animals; Bone Density; Cnidium; Coumarins; Osteoporosis; Rats | 2022 |
Other Studies
376 other study(ies) available for osthol and warfarin
| Article | Year |
|---|---|
Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Coumarins; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; In Vitro Techniques; Inositol Phosphates; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Vasodilation | 1992 |
Determination of osthole and columbianetin acetate in Angelica pubescens by reversed phase HPLC.
Topics: Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Furocoumarins | 1991 |
[Determination of osthol and imperatorin in Cnidium monnieri (L.) cuss by fluorometry TLC scanning].
Topics: Chromatography, Thin Layer; Coumarins; Densitometry; Drugs, Chinese Herbal; Furocoumarins; Spectrometry, Fluorescence | 1990 |
Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Coumarins; Drugs, Chinese Herbal; Phosphatidylinositols; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thromboxane B2 | 1989 |
[The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson].
Topics: Animals; Asthma; Coumarins; Fruit; Guinea Pigs; In Vitro Techniques; Mast Cells; Mice; Muscle Contraction; Muscle, Smooth; Passive Cutaneous Anaphylaxis; Rats | 1988 |
Biologically active principles of crude drugs. Anti-allergic principles in "Cnidii monnieri".
Topics: Animals; Coumarins; Dermatitis, Contact; Furocoumarins; Guinea Pigs; Japan; Male; Mice; Passive Cutaneous Anaphylaxis; Plants, Medicinal | 1985 |
Effects of osthole on isolated guinea pig heart atria.
Topics: Animals; Calcium Channel Blockers; Calcium Chloride; Coumarins; Depression, Chemical; Guinea Pigs; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Plants, Medicinal; Verapamil | 1995 |
[Effects of osthole on the isolated guinea-pig ileum and taeniae coli].
Topics: Acetylcholine; Animals; Calcium; Colon; Coumarins; Female; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Verapamil | 1993 |
The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Coumarins; Cyclic AMP; Cyclic GMP; Drug Interactions; Drugs, Chinese Herbal; Epithelium; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Trachea | 1994 |
[Effects of osthol and total-coumarins from Cnidium monnieri on immunological function in kidney yang deficiency mice].
Topics: Adjuvants, Immunologic; Animals; Coumarins; Drugs, Chinese Herbal; Hemolysin Proteins; Hydrocortisone; Kidney Diseases; Macrophages, Peritoneal; Male; Mice; Phagocytosis; Yang Deficiency | 1995 |
Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro.
Topics: Antiviral Agents; Cell Line; Coumarins; Glycosylation; Hepatitis B Surface Antigens; Hepatitis B virus; Kinetics; Plants, Medicinal; RNA, Messenger; RNA, Viral; Tunicamycin; Virion | 1996 |
Pharmacokinetics of osthole in rat plasma using high-performance liquid chromatography.
Topics: Adjuvants, Immunologic; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Coumarins; Half-Life; Injections, Intravenous; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 1996 |
Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens.
Topics: Animals; Aorta; Calcium Channel Blockers; Cell Count; Colforsin; Coumarins; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Rats; Thymidine; Time Factors | 1996 |
[Quantitative study on the effect of osthole on proximal tibiae in ovariectomized (OVX) rats].
Topics: Animals; Bone Resorption; Calcium Channel Blockers; Coumarins; Delayed-Action Preparations; Female; Humans; Osteoporosis, Postmenopausal; Ovariectomy; Quinestrol; Random Allocation; Rats; Rats, Sprague-Dawley; Tibia | 1996 |
[Effect of osthol and total coumarins of fructus cnidii on thyroid hormone and thyrotropic hormone in kidney-yang deficiency rats].
Topics: Animals; Apiaceae; Coumarins; Hydrocortisone; Kidney Diseases; Male; Rats; Rats, Wistar; Thyrotropin; Thyroxine; Triiodothyronine; Yang Deficiency | 1996 |
[Effects of coumarins from cnidium monnieri on the function of pituitary-adrenocortical axis in kidney yang deficiency rats].
Topics: Adrenocorticotropic Hormone; Animals; Apiaceae; Corticosterone; Coumarins; Hydrocortisone; Kidney Diseases; Male; Pituitary Gland, Anterior; Pituitary-Adrenal System; Rats; Rats, Wistar; Yang Deficiency | 1997 |
Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro.
Topics: Animals; Coumarins; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Plants, Medicinal; Rabbits | 2000 |
Inhibition of concanavalin A-induced mice hepatitis by coumarin derivatives.
Topics: Alanine Transaminase; Animals; Anticoagulants; Concanavalin A; Coumarins; Female; Furocoumarins; Glycyrrhizic Acid; Hepatitis, Animal; Liver; Mice; Mice, Inbred BALB C | 2001 |
The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells.
Topics: Animals; Apiaceae; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cells, Cultured; Coumarins; Isotope Labeling; Methoxsalen; Phosphatidylinositols; Phytotherapy; Pituitary Gland; Potassium; Rats; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone; Tritium | 2001 |
Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.
Topics: Animals; Apiaceae; Biological Assay; Calcium Channel Blockers; Coumarins; Furocoumarins; Male; Methoxsalen; Papaverine; Penis; Phytotherapy; Plant Extracts; Plants, Medicinal; Rabbits; Vasodilation | 2001 |
Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Coumarins; Cyclic AMP; Cyclic GMP; Hybrid Cells; Membrane Potentials; Mice; Neurons; Nimodipine; omega-Conotoxin GVIA; Potassium Channels, Voltage-Gated; Rats; Thionucleotides | 2002 |
Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol.
Topics: Amino Acids; Animals; Biomarkers; Body Weight; Coumarins; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Femur Neck; Humans; Organ Size; Osteocalcin; Osteoporosis, Postmenopausal; Ovariectomy; Rats; Rats, Wistar; Spleen; Stress, Mechanical; Thymus Gland; Tibia; Uterus | 2002 |
Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cnidium; Coumarins; Dermatitis, Contact; Dinitrofluorobenzene; Diphenhydramine; Fruit; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Passive Cutaneous Anaphylaxis; Picryl Chloride; Plant Extracts; Prednisolone; Pruritus; Rats; Rats, Wistar; Skin | 2002 |
[Determination of columbianetin, columbianetin acetate and osthol in Angelica pubescens Maxim. f. biserrata Shan et Yuan by HPLC].
Topics: Angelica; Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Furocoumarins; Plant Roots; Plants, Medicinal | 1999 |
8-(2-bromo-3-methoxy-3-methylbutyl)-7-methoxycoumarin.
Topics: Anti-Inflammatory Agents; Antifungal Agents; Coumarins; Crystallography, X-Ray; Medicine, Chinese Traditional; Molecular Structure; Plants, Medicinal; Seeds; Structure-Activity Relationship; Umbelliferones | 2003 |
Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway.
Topics: Alanine Transaminase; Animals; Antibodies; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Coumarins; Disease Models, Animal; fas Receptor; Female; Mice; Mice, Inbred BALB C | 2003 |
[Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model].
Topics: Acute-Phase Reaction; Aging; Aluminum Chloride; Aluminum Compounds; Animals; Avoidance Learning; Brain; Chlorides; Cnidium; Coumarins; Female; Glutathione Peroxidase; Male; Memory Disorders; Mice; Plants, Medicinal; Random Allocation; Superoxide Dismutase | 2002 |
Pharmacological properties of a crystalline substance (Osthol) isolated from Prangos pabularia Lindl.
Topics: Cardiovascular System; Central Nervous System; Coumarins; Humans; Muscles; Nervous System; Respiration | 1962 |
7-METHOXY-8-ISO-PENTENYL COUMARIN (OSTHOL) -- TOXICITY AND ITS MECHANISM OF RESPIRATORY STIMULANT ACTION.
Topics: Aorta; Blood Pressure; Carotid Body; Coumarins; Decerebrate State; Denervation; Dogs; Pharmacology; Research; Respiration; Respiratory System Agents; Sensory Receptor Cells; Toxicology; Vagotomy | 1964 |
Effect of enhancers on percutaneous absorption of osthol across the excised full thickness rat skin.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Coumarins; Excipients; In Vitro Techniques; Rats; Skin Absorption | 2003 |
Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angelica; Animals; Arachidonic Acid; Aspirin; Benzopyrans; Blood Platelets; Butyrates; Collagen; Coumarins; Furocoumarins; Glucosides; Herbal Medicine; Heterocyclic Compounds, 3-Ring; Korea; Male; Medicine, East Asian Traditional; Methanol; Nephelometry and Turbidimetry; Plant Extracts; Plant Roots; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley | 2003 |
[Pharmacokinetics of osthole in rabbits].
Topics: Animals; Area Under Curve; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cnidium; Coumarins; Fruit; Male; Metabolic Clearance Rate; Plants, Medicinal; Rabbits; Tissue Distribution | 2003 |
Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.
Topics: Cnidium; Coumarins; Countercurrent Distribution; Furocoumarins; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2004 |
Osthole improves aspects of spatial performance in ovariectomized rats.
Topics: Animals; Cnidium; Coumarins; Drugs, Chinese Herbal; Estradiol; Female; Maze Learning; Mydriatics; Ovariectomy; Phytotherapy; Progesterone; Rats; Rats, Sprague-Dawley; Scopolamine; Spatial Behavior | 2004 |
Identification of osthole in Hseh Tsuang seed.
Topics: Coumarins; Humans; Pharmaceutical Preparations; Seeds | 1950 |
[Effects of osthol on androgen level and nitric oxide synthase activity in castrate rats].
Topics: Androgens; Animals; Cnidium; Coumarins; Disease Models, Animal; Drugs, Chinese Herbal; Follicle Stimulating Hormone; Gonadotropins; Luteinizing Hormone; Male; Nitric Oxide; Nitric Oxide Synthase; Orchiectomy; Rats; Rats, Wistar; Testosterone | 2004 |
[Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].
Topics: Angelica; Apiaceae; Capsules; Chromatography, High Pressure Liquid; Common Cold; Coumarins; Drug Combinations; Drugs, Chinese Herbal; Furocoumarins; Plants, Medicinal; Quality Control | 2004 |
Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells.
Topics: Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coumarins; DNA-Binding Proteins; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteoporosis; p38 Mitogen-Activated Protein Kinases; RNA, Small Interfering; Smad Proteins; Smad1 Protein; Trans-Activators; Transforming Growth Factor beta | 2005 |
[Determination of osthol in Shefengshi liqueur by HPLC].
Topics: Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Wine | 2005 |
[Study on extraction of coumarins in Cnidium monieri by supercritical CO2 and separation of compositions analysis].
Topics: Chromatography, Supercritical Fluid; Cnidium; Coumarins; Fruit; Furocoumarins; Plants, Medicinal | 2005 |
HPLC determination and pharmacokinetics of osthole in rat plasma after oral administration of Fructus Cnidii extract.
Topics: Administration, Oral; Animals; Apiaceae; Chromatography, High Pressure Liquid; Coumarins; Plant Extracts; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Toxic epidermal necrolysis associated with high intake of sildenafil and its response to infliximab.
Topics: Aged; Antibodies, Monoclonal; Coumarins; Dermatologic Agents; Drugs, Chinese Herbal; Humans; Infliximab; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Stevens-Johnson Syndrome; Sulfones | 2005 |
Anti-inflammatory effect and mechanism of osthole in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Coumarins; Dose-Response Relationship, Drug; Edema; Female; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase; Plants, Medicinal; Prostaglandins; Rats; Rats, Wistar | 2005 |
Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals.
Topics: Adjuvants, Immunologic; Animals; Cholesterol; Cholesterol, LDL; Coumarins; Fatty Liver; Fatty Liver, Alcoholic; Glutathione Peroxidase; Hyperlipidemias; Male; Malondialdehyde; Quail; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Triglycerides | 2006 |
Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cnidium; Coumarins; DNA Fragmentation; Dose-Response Relationship, Drug; Fruit; HeLa Cells; Humans; Inhibitory Concentration 50; Mice; Phytotherapy | 2007 |
Synthetic derivatives of osthole for the prevention of hepatitis.
Topics: Alanine Transaminase; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Concanavalin A; Coumarins; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indicators and Reagents; Mice; Mice, Inbred BALB C; T-Lymphocytes | 2007 |
Therapeutic effect of osthole on hyperlipidemic fatty liver in rats.
Topics: Animals; Antioxidants; Cnidium; Coumarins; Fatty Liver; Fenofibrate; Hyperlipidemias; Hypolipidemic Agents; Lipase; Lipids; Liver; Male; Mice; Rats; Rats, Sprague-Dawley | 2007 |
Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cholesterol; Cnidium; Coumarins; Fruit; Hydroxymethylglutaryl CoA Reductases; Lipid Metabolism; Liver; Male; Plant Extracts; Rats; Rats, Inbred SHR; RNA, Messenger; Stroke; Triglycerides | 2007 |
Fluorimetric and mass spectrometric study of the interaction of beta-cyclodextrin and osthole.
Topics: beta-Cyclodextrins; Coumarins; Kinetics; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization | 2007 |
Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
Topics: Animals; Cholesterol; Cnidium; Coumarins; Dietary Fats; DNA Primers; Fatty Liver; Fruit; Gene Expression Regulation; Hypolipidemic Agents; Male; Milk; Phytotherapy; Plant Extracts; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Triglycerides | 2007 |
Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS.
Topics: Animals; Chromatography, Liquid; Coumarins; Drug Stability; Drugs, Chinese Herbal; Female; Flavonoids; Male; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |
[Simultaneous determination of 5 active components in Fructus Cnidii by HPLC].
Topics: 5-Methoxypsoralen; Chromatography, High Pressure Liquid; Cnidium; Coumarins; Fruit; Furocoumarins; Methoxsalen; Plants, Medicinal; Reproducibility of Results | 2007 |
Determination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extraction.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Coumarins; Male; Molecular Structure; Rats; Rats, Wistar; Sodium Chloride; Surface-Active Agents; Temperature; Time Factors | 2008 |
Inhibitory effect of osthole on alcohol-induced fatty liver in mice.
Topics: Adjuvants, Immunologic; Animals; Coumarins; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver, Alcoholic; Glutathione; Lipid Metabolism; Liver; Male; Malondialdehyde; Mice; Organ Size; Superoxide Dismutase; Triglycerides; Tumor Necrosis Factor-alpha | 2009 |
[In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis].
Topics: Angelica; Animals; Chromatography, High Pressure Liquid; Colon; Coumarins; Drugs, Chinese Herbal; Duodenum; Furocoumarins; Ileum; Intestinal Absorption; Jejunum; Male; Perfusion; Plant Roots; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2008 |
[Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model].
Topics: Absorption; Angelica; Caco-2 Cells; Coumarins; Furocoumarins; Humans; Plant Roots; Umbelliferones | 2008 |
Isolation and identification of insecticidal components from Citrus aurantium fruit peel extract.
Topics: 5-Methoxypsoralen; Animals; Chemical Fractionation; Citrus; Coumarins; Fruit; Furocoumarins; Insecticides; Methoxsalen; Tephritidae | 2008 |
Micelle-mediated extraction and cloud-point preconcentration of osthole and imperatorin from Cnidium monnieri with analysis by high performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cnidium; Coumarins; Furocoumarins; Micelles; Molecular Structure; Reproducibility of Results | 2008 |
Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus.
Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Fish Diseases; Furocoumarins; Gills; Goldfish; Lethal Dose 50; Random Allocation; Time Factors; Treatment Outcome; Trematoda; Trematode Infections | 2008 |
Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals.
Topics: Amino Acid Transport System X-AG; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cnidium; Coumarins; Dose-Response Relationship, Drug; Exocytosis; Furocoumarins; Glutamic Acid; Hippocampus; Male; Phosphorylation; Plant Extracts; Potassium Channel Blockers; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Synaptic Vesicles; Synaptosomes | 2008 |
Attempts to bridge the gap between scientific mechanism-based medicine and Chinese herbal extract treatment for asthma.
Topics: Asthma; Coumarins; Drugs, Chinese Herbal; Humans | 2008 |
Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells.
Topics: Bronchi; Cell Line; Chemokines, CC; Coumarins; Drugs, Chinese Herbal; Epithelial Cells; Humans; Interleukin-4 | 2008 |
Osthole suppresses seizures in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Mice; Seizures; Time Factors | 2009 |
Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS.
Topics: Caco-2 Cells; Chromatography, High Pressure Liquid; Coumarins; Humans; Models, Biological; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2009 |
Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM).
Topics: Coumarins; Drug Discovery; Drugs, Chinese Herbal; HeLa Cells; Humans; Medicine, Chinese Traditional; Molecular Biology | 2009 |
Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study.
Topics: Angelica archangelica; Animals; Anticonvulsants; Behavior, Animal; Cnidium; Coumarins; Dogs; Dose-Response Relationship, Drug; Electroshock; Furocoumarins; Mice; Neurotoxicity Syndromes; Plant Roots; Postural Balance; Seizures; Valproic Acid | 2009 |
Osthol is a use-dependent blocker of voltage-gated Na+ channels in mouse neuroblastoma N2A cells.
Topics: Animals; Cell Line, Tumor; Coumarins; Drugs, Chinese Herbal; Ion Channel Gating; Magnoliopsida; Mice; Neoplasms; Neuroblastoma; Neuroprotective Agents; Phytotherapy; Sodium Channel Blockers; Sodium Channels | 2010 |
Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.
Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Adenylate Kinase; Adipocytes; Animals; Base Sequence; Cell Differentiation; Coumarins; DNA Primers; Dose-Response Relationship, Drug; Hyperglycemia; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Phosphorylation; PPAR alpha; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
A vascular smooth muscle/cell membrane chromatography-offline-gas chromatography/mass spectrometry method for recognition, separation and identification of active components from traditional Chinese medicines.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; Chromatography; Coumarins; Drugs, Chinese Herbal; Furocoumarins; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2009 |
Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin.
Topics: Animals; Biological Products; Brain; Coumarins; Culture Media, Conditioned; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Interferon-gamma; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Nerve Growth Factor; Peptide Fragments; Spleen | 2010 |
Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Agents; Coumarins; Cytochalasin D; Enzyme Inhibitors; Furocoumarins; Glutamic Acid; Hippocampus; Ionomycin; Male; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Synapsins; Synaptic Vesicles | 2010 |
Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine.
Topics: Animals; Cholesterol 7-alpha-Hydroxylase; Cnidium; Coumarins; Diacylglycerol O-Acyltransferase; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver, Alcoholic; Fruit; Gene Expression; Hepatocytes; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Phytotherapy; PPAR alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
[Metabolism of osthol in isolated hepatocytes of rat].
Topics: Animals; Cells, Cultured; Cnidium; Coumarins; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hepatocytes; Male; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Rifampin; Sulfaphenazole; Troleandomycin; Yohimbine | 2009 |
Effects of osthole on apoptosis and TGF-beta1 of hypertrophic scar fibroblasts.
Topics: Apoptosis; Cicatrix, Hypertrophic; Coumarins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibroblasts; Humans; Molecular Structure; Transforming Growth Factor beta1 | 2009 |
Efficacy of osthol, a potent coumarin compound, in controlling powdery mildew caused by Sphaerotheca fuliginea.
Topics: Ascomycota; Coumarins; Cucurbita; Molecular Structure; Plant Diseases | 2009 |
Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling.
Topics: Animals; beta Catenin; Biomechanical Phenomena; Bone Morphogenetic Protein 2; Bone Resorption; Cell Differentiation; Coumarins; Female; Mice; Osteoblasts; Osteogenesis; Ovariectomy; Rats; Signal Transduction; Wnt Proteins | 2010 |
Synthesis of N-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase.
Topics: Binding Sites; Catalytic Domain; Computer Simulation; Coumarins; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lymphoma, T-Cell; Vorinostat | 2010 |
Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
Topics: Breast Neoplasms; Cell Line, Tumor; Coumarins; Fatty Acid Synthases; Genes, erbB-2; Humans; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2010 |
Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus.
Topics: Animals; Antioxidants; Apoptosis; Carotid Artery, Common; Catalase; Cognition; Coumarins; Gene Expression Regulation; Glutathione Peroxidase; Hippocampus; In Vitro Techniques; Ligation; Malondialdehyde; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors | 2010 |
Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
Topics: Active Transport, Cell Nucleus; Adjuvants, Immunologic; Anti-HIV Agents; Coumarins; HeLa Cells; HIV-1; Humans; Plant Extracts; Plants, Medicinal; rev Gene Products, Human Immunodeficiency Virus; Structure-Activity Relationship | 2010 |
Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Nucleus; Cell Survival; Chromatography, High Pressure Liquid; Coumarins; Cytochromes c; DNA Fragmentation; Flow Cytometry; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; MPTP Poisoning; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; RNA, Messenger | 2010 |
Effects of osthole on migration and invasion in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Coumarins; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Promoter Regions, Genetic; Wound Healing | 2010 |
Antifungal activity of the osthol derivative JS-B against Phytophthora capsici.
Topics: Antifungal Agents; Coumarins; Microbial Sensitivity Tests; Molecular Structure; Phytophthora | 2010 |
Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.
Topics: Adiponectin; Animals; Blood Glucose; Cnidium; Coumarins; Dietary Fats; Dietary Sucrose; Fatty Liver; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Inflammation; Insulin; Insulin Resistance; Lipids; Liver; Male; Peroxisome Proliferator-Activated Receptors; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones | 2011 |
Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Cell Line; Cnidium; Coumarins; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Plant Extracts; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species; Seeds; Tumor Necrosis Factor-alpha | 2010 |
Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Coumarins; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2010 |
[Effect of Osthol on the proliferation and differentiate of osteoblasts in vitro].
Topics: Alkaline Phosphatase; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coumarins; Female; Male; Osteoblasts; Rats; Rats, Sprague-Dawley | 2010 |
Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress.
Topics: Animals; Cholesterol; Cholesterol, LDL; Cnidium; Coumarins; Cytochrome P-450 CYP2E1; Diacylglycerol O-Acyltransferase; Disease Models, Animal; Fatty Liver, Alcoholic; Fruit; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Malondialdehyde; Mice; Oxidative Stress; Superoxide Dismutase; Time Factors; Triglycerides | 2011 |
Discovery of novel osthole derivatives as potential anti-breast cancer treatment.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cnidium; Coumarins; Female; Humans | 2010 |
HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.
Topics: Angelica; Animals; Chlorides; Chromatography, High Pressure Liquid; Coumarins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; GABA Agonists; Heterocyclic Compounds, 3-Ring; Oocytes; Plant Roots; Receptors, GABA-A; Xenopus | 2011 |
Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats.
Topics: Animals; Cerebral Infarction; Coumarins; Enzyme Activation; Ischemic Attack, Transient; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Motor Activity; Rats; Rats, Sprague-Dawley | 2011 |
[Effect of water-soluble polymers on the inhibition of osthole crystallization].
Topics: Cellulose; Cnidium; Coumarins; Crystallization; Hypromellose Derivatives; Kinetics; Methylcellulose; Plants, Medicinal; Poloxamer; Polymers; Povidone; Solubility; Viscosity | 2010 |
Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway.
Topics: Apoptosis; bcl-Associated Death Protein; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Coumarins; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; G2 Phase; Humans; Lung Neoplasms; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Signal Transduction | 2011 |
Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Cerebral Cortex; Coumarins; Drug Interactions; Enzyme Inhibitors; Glucose; Hypoxia; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinases; Neurons; Neuroprotective Agents; Rats; Reperfusion; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors | 2011 |
Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.
Topics: Animals; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Coumarins; Dietary Fats; Fatty Acid Synthases; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Liver; Male; Mice; Milk; Non-alcoholic Fatty Liver Disease; Organ Size; Receptors, LDL; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Sterol Regulatory Element Binding Proteins; Triglycerides | 2011 |
Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro.
Topics: Alkaline Phosphatase; Animals; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Calcification, Physiologic; Calcium Channel Blockers; Cell Differentiation; Cell Proliferation; Cnidium; Collagen; Collagen Type I; Coumarins; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibroblasts; Fruit; Insulin-Like Growth Factor I; Models, Animal; Osteoblasts; Osteocalcin; Osteoporosis; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Preparations; Rats; Rats, Wistar; Skull; Transforming Growth Factor beta | 2011 |
Application of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasma.
Topics: Animals; Calcium Channel Blockers; Cerebral Infarction; Chromatography, High Pressure Liquid; Coumarins; Disease Models, Animal; Humans; Male; Rats; Rats, Wistar; Solid Phase Microextraction | 2011 |
Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Chlorides; Coumarins; Electric Conductivity; Furocoumarins; Models, Molecular; Molecular Conformation; Oocytes; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2011 |
Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells.
Topics: Breast Neoplasms; Coumarins; Epithelial-Mesenchymal Transition; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Signal Transduction; TOR Serine-Threonine Kinases | 2011 |
[Inhibitory acting mechanism of psoralen-osthole on bone metastasis of breast cancer--an expatiation viewing from OPG/RANKL/RANK system].
Topics: Animals; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Coumarins; Female; Ficusin; Interleukin-8; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Osteoprotegerin; Parathyroid Hormone-Related Protein; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B | 2011 |
Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.
Topics: Animals; Cardiotonic Agents; Collagen; Coumarins; Fibrosis; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart; Isoproterenol; Male; Mice; Myocardium; PPAR alpha; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1 | 2011 |
[Effects and mechanisms of osthole on sciatica induced by lumber disc herniation].
Topics: Analgesics; Animals; Behavior, Animal; Coumarins; Cyclooxygenase 2; Disease Models, Animal; Ganglia, Spinal; Injections, Epidural; Intervertebral Disc Displacement; Lumbar Vertebrae; Male; Nitric Oxide Synthase; Pain Measurement; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Sciatica; Spinal Nerve Roots | 2011 |
[Inhibitory effects of osthole, psoralen and aconitine on invasive activities of breast cancer MDA-MB-231BO cell line and the mechanisms].
Topics: Aconitine; Breast Neoplasms; Cell Line, Tumor; Coumarins; Female; Ficusin; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; NF-kappa B; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Smad Proteins | 2011 |
Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.
Topics: Cell Line, Tumor; Cell Proliferation; Cnidium; Coumarins; Furocoumarins; Hep G2 Cells; Humans; Plant Extracts; Seeds; Sitosterols | 2012 |
Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings.
Topics: Animals; Carbazoles; Coumarins; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Glutamic Acid; Guanylate Cyclase; Hippocampus; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Thionucleotides | 2012 |
Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Blood Glucose; Cell Line; Cnidium; Coumarins; Diabetes Mellitus, Experimental; Enzyme Activation; Glucose; Glucose Transporter Type 4; Hep G2 Cells; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Mice; Mice, Inbred ICR; Muscle, Skeletal; Phosphorylation; Taiwan | 2011 |
Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Cnidium; Coumarins; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley | 2012 |
[Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines].
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Synergism; Drugs, Chinese Herbal; Female; Humans; Neoplasm Invasiveness; Ophiopogon; Saponins; Sesquiterpenes; Triterpenes | 2012 |
Mechanism of osthole inhibition of vascular Ca(v)1.2 current.
Topics: Animals; Arteries; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cnidium; Coumarins; Male; Membrane Potentials; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Vasodilator Agents | 2012 |
Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti.
Topics: Aedes; Animals; Cnidium; Coumarins; Culex; Drug Resistance; Fruit; Furocoumarins; Insecticides; Larva; Quantitative Structure-Activity Relationship | 2012 |
Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
Topics: Adenocarcinoma; Binding Sites; Cell Line, Tumor; Cell Movement; Coumarins; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Medicine, Chinese Traditional; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; RNA, Messenger | 2012 |
[Effect of osthol on apoptosis and bone resorption of osteoclasts cultured in vitro].
Topics: Acid Phosphatase; Animals; Apoptosis; Bone Resorption; Cells, Cultured; Cnidium; Coumarins; Gene Expression; Isoenzymes; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Osteoclasts; Osteoprotegerin; Phosphorylation; Plants, Medicinal; Rabbits; RANK Ligand; Seeds; Signal Transduction; Tartrate-Resistant Acid Phosphatase | 2012 |
Isolation and identification of metabolites of osthole in rats.
Topics: Adjuvants, Immunologic; Animals; Cnidium; Coumarins; Male; Molecular Structure; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2012 |
Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.
Topics: Acid Sensing Ion Channels; Analgesics; Animals; Blotting, Western; Coumarins; Fluorescent Antibody Technique; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalgesia; Intervertebral Disc; Male; Membrane Potentials; Nerve Tissue Proteins; Neurons; Nociception; Pain; Pain Threshold; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Sodium Channels | 2012 |
Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Coumarins; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; NF-kappa B | 2012 |
Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish.
Topics: Animals; Antiplatyhelmintic Agents; Chemistry Techniques, Synthetic; Coumarins; Goldfish; Platyhelminths; Quantitative Structure-Activity Relationship; Safety; Toxicity Tests | 2012 |
Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats.
Topics: Animals; Anti-Inflammatory Agents; Cerebral Cortex; Coumarins; Cyclooxygenase 2; Infarction, Middle Cerebral Artery; Interleukin-1beta; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha | 2012 |
Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.
Topics: Animals; Cardiomegaly; Carnitine O-Palmitoyltransferase; Cnidium; Coumarins; Diacylglycerol O-Acyltransferase; Glutathione Peroxidase; Lipid Metabolism; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase | 2012 |
Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro.
Topics: Calcium Channel Blockers; Cell Line, Tumor; Cell Movement; Cnidium; Coumarins; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Plants, Medicinal | 2012 |
Modification of rat model of sciatica induced by lumber disc herniation and the anti-inflammatory effect of osthole given by epidural catheterization.
Topics: Animals; Anti-Inflammatory Agents; Catheterization; Coumarins; Cyclooxygenase 2; Disease Models, Animal; Injections, Epidural; Intervertebral Disc Displacement; Lumbar Vertebrae; Male; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Sciatica | 2012 |
Comparative study of pharmacokinetics and tissue distribution of osthole in rats after oral administration of pure osthole and Libanotis buchtormensis supercritical extract.
Topics: Administration, Oral; Analgesics; Animals; Apiaceae; Coumarins; Female; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2013 |
Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats.
Topics: Animals; Blotting, Western; Chromones; Coumarins; Dose-Response Relationship, Drug; Endothelial Cells; Female; Gene Expression Regulation; Humans; Male; Mesenteric Arteries; Middle Aged; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Species Specificity; Vasodilation | 2013 |
Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, Liquid; Cnidium; Coumarins; Female; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2013 |
[Inhibition effect of osthole on proliferation of rat chondrocytes].
Topics: Animals; Cell Proliferation; Cells, Cultured; Chondrocytes; Collagen Type II; Coumarins; Cyclin D1; Down-Regulation; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley | 2012 |
Coumarins from the Herb Cnidium monnieri and chemically modified derivatives as antifoulants against Balanus albicostatus and Bugula neritina larvae.
Topics: Animals; Bryozoa; Cnidium; Coumarins; Dose-Response Relationship, Drug; Furocoumarins; Larva; Lethal Dose 50; Models, Chemical; Molecular Structure; Plant Extracts; Thoracica | 2013 |
Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of angiotensin-converting enzyme 2.
Topics: Acute Lung Injury; Angiotensin I; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Line; Coumarins; Down-Regulation; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study.
Topics: Administration, Intravenous; Administration, Oral; Animals; Chromatography, Liquid; Coumarins; Drug Stability; Furocoumarins; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis e
Topics: 5-Methoxypsoralen; Acetates; Administration, Oral; Animals; Chromatography, Liquid; Coumarins; Drugs, Chinese Herbal; Ficusin; Furocoumarins; Liquid-Liquid Extraction; Male; Methoxsalen; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Scopoletin; Tandem Mass Spectrometry | 2013 |
Osthole ameliorates renal ischemia-reperfusion injury in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apiaceae; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Coumarins; Drug Evaluation, Preclinical; Enzyme Activation; Kidney; Male; Oxidative Stress; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response.
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Coumarins; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Inflammation; Interleukin-1beta; Kidney; Male; Monocytes; p38 Mitogen-Activated Protein Kinases; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2013 |
Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice.
Topics: Animals; Antioxidants; Coumarins; Disease Models, Animal; Intestines; Male; Mice; Neutrophil Infiltration; NF-kappa B; Nitric Oxide; Oxidative Stress; Reperfusion Injury; Signal Transduction | 2013 |
Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Coumarins; Gene Expression Regulation, Neoplastic; Humans; Mice; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Saponins; Smad Proteins; Transforming Growth Factor beta; Triterpenes | 2013 |
Osthole improves acute lung injury in mice by up-regulating Nrf-2/thioredoxin 1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Cell Line, Transformed; Cell Survival; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Organ Size; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; RNA, Small Interfering; Statistics, Nonparametric; Survival Analysis; Thioredoxins; Time Factors; Transfection; Up-Regulation | 2013 |
Biotransformation of osthole by Alternaria longipes.
Topics: Alternaria; Biotransformation; Coumarins; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular | 2013 |
Protective effects of osthole against myocardial ischemia/reperfusion injury in rats.
Topics: Animals; Calcium Channel Blockers; Catalase; Coumarins; Cytokines; Disease Models, Animal; Enzyme Activation; Hemodynamics; HMGB1 Protein; Inflammation Mediators; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Myocardium; NF-kappa B; Oxidative Stress; Rats; Superoxide Dismutase | 2013 |
Osthole attenuates hepatic injury in a rodent model of trauma-hemorrhage.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Coumarins; Hemorrhage; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Wounds and Injuries | 2013 |
DNA microarray gene expression profile of Mycobacterium tuberculosis when exposed to osthole.
Topics: Adjuvants, Immunologic; Coumarins; Gene Expression Regulation, Bacterial; Molecular Structure; Mycobacterium tuberculosis; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Ribosomes; Succinate Dehydrogenase; Transcriptome; Trehalose | 2013 |
Osthole attenuates spinal cord ischemia-reperfusion injury through mitochondrial biogenesis-independent inhibition of mitochondrial dysfunction in rats.
Topics: Animals; Calcium Channel Blockers; Cnidium; Coumarins; Drugs, Chinese Herbal; Hemodynamics; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord Injuries | 2013 |
[Effect of osthole on proliferation of neonatal rat osteoblast and the relative mechanism research].
Topics: Animals; Animals, Newborn; beta Catenin; Cell Differentiation; Cell Division; Cell Proliferation; Cells, Cultured; Coumarins; Female; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Signal Transduction | 2013 |
Simultaneous quantification of Kirenol and ent-16β,17-dihydroxy-kauran-19-oic acid from Herba Siegesbeckiae in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies.
Topics: Animals; Asteraceae; Chromatography, Liquid; Coumarins; Diterpenes; Diterpenes, Kaurane; Drug Stability; Linear Models; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
The effect of the coumarin-like derivative osthole on the osteogenic properties of human periodontal ligament and jaw bone marrow mesenchymal stem cell sheets.
Topics: Adolescent; Adult; Bone Marrow Cells; Cell Proliferation; Cell Survival; Cells, Cultured; Coumarins; Flow Cytometry; Humans; Jaw; Mesenchymal Stem Cells; Osteogenesis; Periodontal Ligament; Young Adult | 2013 |
Synthesis and characterization of low-toxicity N-caprinoyl-N-trimethyl chitosan as self-assembled micelles carriers for osthole.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chitosan; Coumarins; Diffusion; Drug Compounding; Humans; Micelles; Nanocapsules; Neoplasms, Experimental; Particle Size; Treatment Outcome | 2013 |
N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Colonic Neoplasms; Coumarins; DNA Damage; Down-Regulation; G2 Phase Cell Cycle Checkpoints; Humans; Hydroxamic Acids; M Phase Cell Cycle Checkpoints; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Signal Transduction; Up-Regulation | 2013 |
[Study on the chemical constituent from the dichloromethane extract of the pine needle of Cedrus deodara (II)].
Topics: Acetophenones; Biphenyl Compounds; Cedrus; Chromatography, Thin Layer; Coumaric Acids; Coumarins; Lignans; Methylene Chloride; Molecular Structure; Plant Leaves | 2013 |
Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses.
Topics: Administration, Oral; Alpinia; Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cnidium; Coumarins; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal; Fruit; Medicine, Chinese Traditional; Plant Extracts; Rats; Rats, Sprague-Dawley; Time Factors | 2014 |
[Effect of osthole on bone metabolism in rat femoral tissues in vitro].
Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 2; Calcium; Core Binding Factor Alpha 1 Subunit; Coumarins; Femur; In Vitro Techniques; Male; Osteoprotegerin; RANK Ligand; Rats; Rats, Sprague-Dawley | 2013 |
Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway.
Topics: Animals; Apoptosis; Blotting, Western; Calcium Channel Blockers; Carrier Proteins; Caspases; Coumarins; Glomerulonephritis, IGA; Inflammation; Kidney; Macrophages; Mesangial Cells; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Signal Transduction | 2013 |
Osthole inhibits proliferation and induces apoptosis in human osteosarcoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Bone Neoplasms; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cell Proliferation; Coumarins; Humans; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2 | 2014 |
Osthole induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Culture Techniques; Cell Proliferation; Cell Survival; Cnidium; Coumarins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fruit; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; M Phase Cell Cycle Checkpoints; Molecular Structure; Time Factors | 2014 |
Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.
Topics: Animals; Antineoplastic Agents; Capillaries; Cell Movement; Cell Proliferation; Coumarins; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; HCT116 Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2013 |
Osthole exhibits anti-cancer property in rat glioma cells through inhibiting PI3K/Akt and MAPK signaling pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coumarins; Down-Regulation; Glioma; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats | 2013 |
[Effects and mechanism of osthole on intestinal ischemia-reperfusion injury in mice].
Topics: Animals; Coumarins; Interleukin-1beta; Interleukin-2; Intestinal Diseases; Intestines; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II.
Topics: Angiotensin II; Animals; Cells, Cultured; Coumarins; Fibroblasts; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Myocardium; NF-kappa B; PPAR alpha; PPAR gamma; RNA, Messenger; Transcription Factor RelA; Transforming Growth Factor beta1 | 2013 |
Osthole reverses beta-amyloid peptide cytotoxicity on neural cells by enhancing cyclic AMP response element-binding protein phosphorylation.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; bcl-2-Associated X Protein; Cell Line, Tumor; Cells, Cultured; Coumarins; Cyclic AMP Response Element-Binding Protein; Humans; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Synapsins | 2013 |
Osthole augments therapeutic efficiency of neural stem cells-based therapy in experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents; Bone Marrow Transplantation; Cell Differentiation; Cells, Cultured; Coumarins; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Graft Survival; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; Neural Stem Cells; Neurons; Neuroprotective Agents; Oligodendroglia; Stem Cell Transplantation | 2014 |
Osthole attenuates the development of carrageenan-induced lung inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coumarins; Interleukin-1beta; Lung; Male; Peroxidase; Pleurisy; Pneumonia; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Preparation of osthole-polymer solid dispersions by hot-melt extrusion for dissolution and bioavailability enhancement.
Topics: Administration, Oral; Animals; Biological Availability; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Coumarins; Crystallography, X-Ray; Drug Carriers; Male; Polymers; Powder Diffraction; Powders; Rats, Sprague-Dawley; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical | 2014 |
Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cnidium; Coumarins; Dose-Response Relationship, Drug; Down-Regulation; Focal Adhesion Protein-Tyrosine Kinases; Fruit; Glioblastoma; Humans; Matrix Metalloproteinase 13; Phosphorylation; Tyrosine | 2014 |
Osthole activates glucose uptake but blocks full activation in L929 fibroblast cells, and inhibits uptake in HCLE cells.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Line, Transformed; Coumarins; Fibroblasts; Glucose; Humans; Mice | 2014 |
Osthole prevents intestinal ischemia-reperfusion-induced lung injury in a rodent model.
Topics: Acute Lung Injury; Animals; Blood Pressure; Calcium Channel Blockers; Coumarins; Disease Models, Animal; Interleukin-6; Lung; Male; Malondialdehyde; Organ Size; Oxidative Stress; Peroxidase; Pulmonary Gas Exchange; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2014 |
Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cnidium; Coumarins; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Glioblastoma; Humans; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis.
Topics: Active Transport, Cell Nucleus; Animals; Antioxidants; Apoptosis; Calcium Channel Blockers; Cnidium; Coumarins; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Female; Glomerulosclerosis, Focal Segmental; Glutathione Peroxidase; Heme Oxygenase-1; Inflammation; Macrophage Activation; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Plant Preparations; Podocytes; Proteinuria; Reactive Oxygen Species | 2014 |
Protective effects of osthole on intestinal ischemia-reperfusion injury in mice.
Topics: Animals; Antioxidants; Biomarkers; Coumarins; Cytoprotection; Disease Models, Animal; Ileum; Injections, Intravenous; Male; Mesenteric Ischemia; Mesenteric Vascular Occlusion; Mice; Oxidative Stress; Permeability; Reperfusion Injury | 2014 |
N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors.
Topics: Animals; Chitosan; Coumarins; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Lipoproteins; Mice; Mice, Nude; Nanocapsules; Nanoconjugates; Neoplasms, Experimental; Receptors, LDL; Treatment Outcome | 2014 |
Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cholesterol; Coumarins; Cytokines; Diet, High-Fat; Fatty Acid Synthases; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Lipid Metabolism; Lipoprotein Lipase; Liver; Male; NF-kappa B; Non-alcoholic Fatty Liver Disease; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Sucrose | 2014 |
Osthole attenuates doxorubicin-induced apoptosis in PC12 cells through inhibition of mitochondrial dysfunction and ROS production.
Topics: Adrenal Gland Neoplasms; Animals; Apiaceae; Apoptosis; bcl-2-Associated X Protein; Coumarins; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; PC12 Cells; Pheochromocytoma; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species | 2014 |
p53 is a key regulator for osthole-triggered cancer pathogenesis.
Topics: Apoptosis; Cell Proliferation; Coumarins; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; MAP Kinase Kinase 4; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2014 |
Click chemistry inspired synthesis and bioevaluation of novel triazolyl derivatives of osthol as potent cytotoxic agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Coumarins; Cytotoxins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Structure-Activity Relationship | 2014 |
Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance.
Topics: Animals; Biomarkers; Coumarins; Diet, High-Fat; Disease Models, Animal; Insulin Resistance; Liver; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; Time Factors; Triglycerides | 2014 |
[In vitro effect of osthole on ultrastructure of Giardia lamblia].
Topics: Animals; Cell Membrane; Coumarins; Cytoplasm; Giardia lamblia; In Vitro Techniques; Microscopy, Electron, Transmission | 2014 |
Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography-tandem mass spectrometry.
Topics: 5-Methoxypsoralen; Animals; Chromatography, Liquid; Coumarins; Female; Furocoumarins; Linear Models; Male; Methoxsalen; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tissue Distribution | 2014 |
[Comparative study on effect of osthole and genistein on peak bone mass in rats].
Topics: Acid Phosphatase; Animals; Body Weight; Bone Density; Coumarins; Female; Femur; Genistein; Isoenzymes; Osteocalcin; Radiography; Rats; Rats, Sprague-Dawley; Tartrate-Resistant Acid Phosphatase | 2014 |
Osthole induces apoptosis, suppresses cell-cycle progression and proliferation of cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Calcium Channel Blockers; Cell Cycle; Cell Proliferation; Cerebellar Neoplasms; Coumarins; Cyclin-Dependent Kinase Inhibitor p21; Flow Cytometry; Humans; Laryngeal Neoplasms; Medulloblastoma; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2014 |
Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: involvement of Nrf2 pathway.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Coumarins; Heme Oxygenase-1; Hippocampus; Ischemic Attack, Transient; Male; Malondialdehyde; Maze Learning; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-E2-Related Factor 2; Nootropic Agents; Superoxide Dismutase | 2015 |
Anti-metastatic effect and mechanisms of Wenshen Zhuanggu Formula in human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chemokine CCL5; Coculture Techniques; Coumarins; Female; Ficusin; Furocoumarins; Humans; Interleukin-17; Male; Medicine, Chinese Traditional; Mesenchymal Stem Cells; Plant Extracts; Rats, Sprague-Dawley; Serum | 2015 |
Osthole inhibits inflammatory cytokine release through PPARα/γ-mediated mechanisms in LPS-stimulated 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Angelica; Animals; Cell Survival; Coumarins; Cytokines; Inflammation Mediators; Lipopolysaccharides; Mice; PPAR alpha; PPAR gamma | 2015 |
N-hydroxycinnamide derivatives of osthole ameliorate hyperglycemia through activation of AMPK and p38 MAPK.
Topics: AMP-Activated Protein Kinases; Animals; Coumaric Acids; Coumarins; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Hypoglycemic Agents; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Rats; Streptozocin | 2015 |
Osthole Attenuates Inflammatory Responses and Regulates the Expression of Inflammatory Mediators in HepG2 Cells Grown in Differentiated Medium from 3T3-L1 Preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Inflammatory Agents; Apiaceae; Coumarins; Cyclooxygenase 2; Cytokines; Heme Oxygenase-1; Hep G2 Cells; Humans; I-kappa B Proteins; Inflammation; Inflammation Mediators; Interleukins; MAP Kinase Signaling System; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Phytotherapy; Plant Extracts; Signal Transduction | 2015 |
NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells.
Topics: Acetylation; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Coumarins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; G1 Phase; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Lung Neoplasms; Proteasome Endopeptidase Complex; Up-Regulation | 2015 |
Osthole promotes anti-tumor immune responses in tumor-bearing mice with hepatocellular carcinoma.
Topics: Adjuvants, Immunologic; Animals; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Coumarins; Immunity, Cellular; Liver Neoplasms, Experimental; Mice; T-Lymphocytes, Regulatory | 2015 |
Simultaneous determination of icariin, naringin and osthole in rat plasma by UPLC-MS/MS and its application for pharmacokinetic study after oral administration of Gushudan capsules.
Topics: Administration, Oral; Animals; Capsules; Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Female; Flavanones; Flavonoids; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2015 |
Impact of fexofenadine, osthole and histamine on peripheral blood mononuclear cell proliferation and cytokine secretion.
Topics: Adult; Cell Proliferation; Cells, Cultured; Coumarins; Cytokines; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Humans; Interleukin-10; Interleukin-6; Leukocytes, Mononuclear; Male; Terfenadine; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway.
Topics: Adjuvants, Immunologic; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cisplatin; Coumarins; Drug Synergism; Drug Therapy, Combination; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Respiratory Mucosa; RNA, Small Interfering; Signal Transduction | 2015 |
Osthole suppresses the proliferation and accelerates the apoptosis of human glioma cells via the upregulation of microRNA-16 and downregulation of MMP-9.
Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MicroRNAs; Neuroglia; Plant Extracts; Signal Transduction | 2015 |
By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer.
Topics: 3' Untranslated Regions; Animals; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Coumarins; Disease Progression; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Male; Mice; Mice, SCID; MicroRNAs; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Neoplasms; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Wound Healing | 2015 |
Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation.
Topics: Actins; Animals; Coumarins; Cytokines; Hepatic Stellate Cells; Liver Cirrhosis; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thioacetamide | 2015 |
Osthole Inhibits Proliferation and Induces Catabolism in Rat Chondrocytes and Cartilage Tissue.
Topics: ADAM Proteins; ADAMTS5 Protein; Animals; Biomarkers; Cartilage, Articular; Cell Proliferation; Cells, Cultured; Chondrocytes; Coumarins; Extracellular Matrix; Gene Expression Regulation; Glycosaminoglycans; Interleukin-1beta; Matrix Metalloproteinases; Rats, Sprague-Dawley; RNA, Messenger; Wnt Signaling Pathway | 2015 |
The Coumarin Derivative Osthole Stimulates Adult Neural Stem Cells, Promotes Neurogenesis in the Hippocampus, and Ameliorates Cognitive Impairment in APP/PS1 Transgenic Mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Proliferation; Cell Survival; Cognition Disorders; Coumarins; Hippocampus; Maze Learning; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Presenilin-1 | 2015 |
Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Caspase 3; Cerebral Cortex; Coumarins; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurologic Examination; Neuroprotective Agents; Peroxidase; RNA, Messenger; Time Factors | 2015 |
[Osthole ameliorates glutamate-induced toxicity in HT22 cells via activating PI3K/Akt signaling pathway].
Topics: Animals; Caspase 3; Cell Line; Cell Survival; Chromones; Coumarins; Glutamic Acid; Hippocampus; Mice; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
Osthole Upregulates BDNF to Enhance Adult Hippocampal Neurogenesis in APP/PS1 Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotrophic Factor; Coumarins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Neuroprotective Agents; Peptide Fragments; Presenilin-1; Up-Regulation | 2015 |
Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4.
Topics: Acute Lung Injury; Animals; CD11b Antigen; Coumarins; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Extracellular Signal-Regulated MAP Kinases; Humans; Immunoblotting; Male; Neutrophil Activation; Neutrophils; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Signal Transduction; Superoxides | 2015 |
Osthole improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle in fatty liver rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Coumarins; Dose-Response Relationship, Drug; Fatty Liver; Gene Targeting; Glucose; Lipid Metabolism; Liver; Male; Muscle, Skeletal; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley | 2016 |
Osthole, a coumadin analog from Cnidium monnieri (L.) Cusson, stimulates corticosterone secretion by increasing steroidogenic enzyme expression in mouse Y1 adrenocortical tumor cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasms; Animals; Cell Line, Tumor; Cell Survival; Cnidium; Corticosterone; Coumarins; Mice; Phosphoproteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Scavenger Receptors, Class B; Steroid 11-beta-Hydroxylase | 2015 |
Inhibition of osteolysis after local administration of osthole in a TCP particles-induced osteolysis model.
Topics: Adjuvants, Immunologic; Animals; Blotting, Western; Calcium Phosphates; Coumarins; Cytokines; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Osteoclasts; Osteolysis; Prostheses and Implants; Signal Transduction; Skull; Tartrate-Resistant Acid Phosphatase | 2016 |
Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; beta Catenin; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coumarins; Disease Models, Animal; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Neurons; Wnt Signaling Pathway | 2015 |
Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK.
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Cnidium; Coumarins; Cyclooxygenase 2; Gene Expression Regulation; Heart; Interleukin-1beta; Interleukin-6; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; NF-kappa B; Nod1 Signaling Adaptor Protein; Nod2 Signaling Adaptor Protein; Rats; Rats, Wistar; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
Protective role of Osthole on myocardial cell apoptosis induced by doxorubicin in rats.
Topics: Animals; Animals, Newborn; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; bcl-X Protein; Cardiotoxicity; Caspase 3; Cells, Cultured; Coumarins; Cytochromes c; Cytoprotection; Dose-Response Relationship, Drug; Doxorubicin; Eukaryotic Initiation Factor-2; Myocytes, Cardiac; NADP; NADPH Oxidases; Oxidative Stress; Phosphorylation; Rats, Sprague-Dawley; Superoxides | 2015 |
[Inhibition of osthole for resorption of rats femur tissue in vitro].
Topics: Acid Phosphatase; Animals; Bone Resorption; Coumarins; Estradiol; Femur; Glucose; Lactic Acid; Male; Rats; Rats, Sprague-Dawley | 2015 |
Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents; Bleomycin; Collagen; Coumarins; Cytokines; Edema; Lung; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Pulmonary Fibrosis; Rats, Sprague-Dawley; Transforming Growth Factor beta1 | 2016 |
Neuroprotection of Osthole against Cerebral Ischemia/Reperfusion Injury through an Anti-apoptotic Pathway in Rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Coumarins; DNA Fragmentation; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Reperfusion Injury; Water | 2016 |
Osthole shows the potential to overcome P-glycoprotein‑mediated multidrug resistance in human myelogenous leukemia K562/ADM cells by inhibiting the PI3K/Akt signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Coumarins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; K562 Cells; Leukemia, Myeloid; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rhodamine 123; Signal Transduction | 2016 |
Preparation and application of magnetic molecularly imprinted nanoparticles for the selective extraction of osthole in Libanotis Buchtomensis herbal extract.
Topics: Coumarins; Drugs, Chinese Herbal; Magnetite Nanoparticles; Medicine, Chinese Traditional; Molecular Imprinting; Particle Size; Plant Extracts; Surface Properties | 2016 |
Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Cell Line, Tumor; Cell Survival; Cerebral Cortex; Coumarins; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Neuroprotective Agents; Up-Regulation | 2016 |
Optimization of extraction conditions for osthol, a melanogenesis inhibitor from Cnidium monnieri fruits.
Topics: Animals; Cell Line, Tumor; Chemical Fractionation; Chromatography, High Pressure Liquid; Cnidium; Coumarins; Dose-Response Relationship, Drug; Fruit; Intramolecular Oxidoreductases; Melanins; Melanoma, Experimental; Mice; Oxidoreductases; Phytotherapy; Plant Extracts; Plants, Medicinal; Skin Lightening Preparations; Skin Pigmentation; Time Factors | 2016 |
Osthole inhibits histamine-dependent itch via modulating TRPV1 activity.
Topics: Animals; Antipruritics; Calcium; Calcium Channel Blockers; Capsaicin; Cells, Cultured; Coumarins; Ganglia, Spinal; Histamine; Ion Channel Gating; Male; Mice, Inbred C57BL; Neurons; Pruritus; TRPV Cation Channels | 2016 |
Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma.
Topics: Antineoplastic Agents, Phytogenic; Bone Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Coumarins; Humans; Neoplasm Invasiveness; Osteosarcoma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase | 2016 |
[Mechanisms for effect of osthole on inhibiting the growth and invasion of bladder cancer cells].
Topics: Caspase 3; CD13 Antigens; Cell Line, Tumor; Coumarins; Cyclooxygenase 2; ErbB Receptors; Humans; Matrix Metalloproteinase 2; NF-kappa B; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A | 2016 |
An Inhibitory Role of Osthole in Rat MSCs Osteogenic Differentiation and Proliferation via Wnt/β-Catenin and Erk1/2-MAPK Pathways.
Topics: Alkaline Phosphatase; Animals; beta Catenin; Cell Proliferation; Cells, Cultured; Coumarins; Drugs, Chinese Herbal; MAP Kinase Signaling System; Mesenchymal Stem Cells; Osteoblasts; Osteogenesis; Rats; Wnt Signaling Pathway | 2016 |
Preparation of osthole-loaded nano-vesicles for skin delivery: Characterization, in vitro skin permeation and preliminary in vivo pharmacokinetic studies.
Topics: Administration, Cutaneous; Animals; Blood Proteins; Coumarins; Drug Delivery Systems; Drug Liberation; Nanostructures; Particle Size; Rats, Sprague-Dawley; Skin; Skin Absorption; Solubility; Surface Properties; Swine | 2016 |
[Effect of Osthole on Adrenocortical Function in Y1 Mouse Adrenocortical Tumor Cells].
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Corticosterone; Coumarins; Gene Expression; Mice; RNA, Messenger; Tumor Cells, Cultured | 2016 |
Neuroprotective Effect of Osthole on Neuron Synapses in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9.
Topics: Alzheimer Disease; AMP-Activated Protein Kinase Kinases; Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Cells, Cultured; Coumarins; Guanine Nucleotide Exchange Factors; Humans; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Neuroprotective Agents; Protein Kinases; Synapses; Synapsins; Synaptophysin | 2016 |
Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells.
Topics: Alkaline Phosphatase; Cell Line, Tumor; Cell Proliferation; Cnidium; Coumarins; Drugs, Chinese Herbal; Furocoumarins; Humans; MCF-7 Cells; Osteoblasts; Phytoestrogens; Receptors, Estrogen | 2016 |
Efficacy of osthole for Echinococcus granulosus in vitro and Echinococcus multilocularis in vivo.
Topics: Albendazole; Animals; Antiprotozoal Agents; Blood Chemical Analysis; Calcium Channel Blockers; Cell Line; Coumarins; Echinococcosis; Echinococcus granulosus; Echinococcus multilocularis; Eosinophils; Female; Hep G2 Cells; Humans; Interleukin-4; Kidney; Leukocyte Count; Liver; Mice; Mice, Inbred BALB C; Random Allocation; Sheep | 2016 |
Osthole Promotes Endochondral Ossification and Accelerates Fracture Healing in Mice.
Topics: Adjuvants, Immunologic; Animals; Coumarins; Fracture Healing; Male; Mice; Mice, Inbred C57BL; Osteogenesis | 2016 |
Microwave-assisted synthesis and antifungal activity of novel fused Osthole derivatives.
Topics: Antifungal Agents; Chemistry Techniques, Synthetic; Coumarins; Drug Design; Fungi; Microwaves | 2016 |
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Coumarins; Cyclin B1; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Protease Inhibitors | 2016 |
Osteoprotective effects of osthole in a mouse model of 5/6 nephrectomy through inhibiting osteoclast formation.
Topics: Animals; Bone Resorption; Coumarins; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Nephrectomy; Osteoblasts; Osteoclasts; Osteoprotegerin; RANK Ligand | 2016 |
Osthole Protects Bone Marrow-Derived Neural Stem Cells from Oxidative Damage through PI3K/Akt-1 Pathway.
Topics: Animals; Bone Marrow; Cell Survival; Cells, Cultured; Coumarins; Cytoprotection; Dose-Response Relationship, Drug; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Neural Stem Cells; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2017 |
Cytokine production by PBMC and serum from allergic and non-allergic subjects following in vitro histamine stimulation to test fexofenadine and osthole anti-allergic properties.
Topics: Adult; Anti-Allergic Agents; Coumarins; Cytokines; Histamine; Humans; Hypersensitivity; Immunoglobulin E; Leukocytes, Mononuclear; Male; Terfenadine | 2016 |
A Multiscale Study on the Penetration Enhancement Mechanism of Menthol to Osthole.
Topics: Cell Membrane; Coumarins; Diffusion; Epidermis; Lipid Bilayers; Menthol; Molecular Conformation; Molecular Dynamics Simulation; Permeability; Skin Absorption | 2016 |
Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H
Topics: Adult; Case-Control Studies; Chemokine CCL5; Coumarins; Cyclooxygenase 2; Female; Gene Expression Regulation; Histamine; Humans; Hypersensitivity; Interleukin-1beta; Leukocytes, Mononuclear; Male; NF-kappa B; Receptors, Histamine H1; RNA, Messenger; Terfenadine | 2017 |
Osthole inhibits the expressions of collagen I and III through Smad signaling pathway after treatment with TGF-β1 in mouse cardiac fibroblasts.
Topics: Animals; Blotting, Western; Cardiomyopathies; Cells, Cultured; Collagen Type I; Collagen Type III; Coumarins; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression Regulation; Mice; Myocardium; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2017 |
The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia.
Topics: A549 Cells; Animals; Bacterial Toxins; Coumarins; Disease Models, Animal; Drug Therapy, Combination; Flavonoids; Gene Expression Regulation, Bacterial; Hemolysin Proteins; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Pneumonia, Staphylococcal | 2017 |
Osthole protects sepsis-induced acute kidney injury via down-regulating NF-κB signal pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Macrophages; Male; Mice; NF-kappa B; RAW 264.7 Cells; Sepsis; Signal Transduction; Treatment Outcome | 2017 |
Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain.
Topics: Analgesics; Angelica; Animals; Chromatography, High Pressure Liquid; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Inflammation Mediators; Male; Neuralgia; Pain Threshold; Phosphorylation; Phytotherapy; Plant Roots; Plants, Medicinal; Rats, Sprague-Dawley; Signal Transduction; Time Factors; TRPV Cation Channels | 2017 |
Influence of Temperature on Transdermal Penetration Enhancing Mechanism of Borneol: A Multi-Scale Study.
Topics: Administration, Cutaneous; Animals; Camphanes; Coumarins; Lipid Bilayers; Molecular Dynamics Simulation; Rats; Skin; Temperature | 2017 |
Anti-asthmatic activity of osthole in an ovalbumin-induced asthma murine model.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Coumarins; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoglobulin E; Mice; NF-kappa B; Ovalbumin | 2017 |
Osthole inhibited TGF β-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells.
Topics: A549 Cells; Cadherins; Coumarins; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; NF-kappa B; Proline; Snail Family Transcription Factors; Thiocarbamates; Transcription Factor RelA; Transforming Growth Factor beta | 2017 |
The Natural Product Osthole Attenuates Yeast Growth by Extensively Suppressing the Gene Expressions of Mitochondrial Respiration Chain.
Topics: Coumarins; Mitochondria; Oligonucleotide Array Sequence Analysis; Saccharomyces cerevisiae; Schizosaccharomyces | 2017 |
Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells.
Topics: Apoptosis; Blotting, Western; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Coumarins; Epithelial-Mesenchymal Transition; Humans; Liver Neoplasms; Signal Transduction; Tumor Cells, Cultured; Wound Healing | 2017 |
PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats.
Topics: Anilides; Animals; Coumarins; Fatty Acids, Nonesterified; Fatty Liver; Indoles; Inflammation; Lipid Metabolism; Liver; Male; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Triglycerides | 2018 |
Osthole prevents cerebral ischemia-reperfusion injury via the Notch signaling pathway.
Topics: Animals; Brain Ischemia; Coumarins; Male; Rats; Rats, Sprague-Dawley; Receptors, Notch; Reperfusion Injury; Signal Transduction | 2017 |
Metabolic map of osthole and its effect on lipids.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Coumarins; Hydrogenation; Hydroxylation; Inactivation, Metabolic; Lipids; Lysophosphatidylcholines; Lysophospholipids; Male; Metabolomics; Methylation; Mice; Microsomes, Liver; Molecular Structure; Peritoneal Absorption; Spectrometry, Mass, Electrospray Ionization | 2018 |
Osthole enhances TRAIL-mediated apoptosis through downregulation of c-FLIP expression in renal carcinoma Caki cells.
Topics: Apoptosis; Carcinoma, Renal Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coumarins; Down-Regulation; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Membrane Potential, Mitochondrial; TNF-Related Apoptosis-Inducing Ligand | 2017 |
Different effects of (+)‑borneol and (‑)‑borneol on the pharmacokinetics of osthole in rats following oral administration.
Topics: Administration, Oral; Animals; Area Under Curve; Camphanes; Coumarins; Drugs, Chinese Herbal; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley | 2017 |
Osthole attenuates lipid accumulation, regulates the expression of inflammatory mediators, and increases antioxidants in FL83B cells.
Topics: Adipogenesis; AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Death; Cell Line; Coumarins; Cyclooxygenase 2; Fatty Acid Synthases; Fatty Liver; Gene Expression Regulation; Hepatocytes; Hydrogen Peroxide; Inflammation Mediators; Lipids; Lipolysis; Mice; NF-kappa B; Phosphorylation; RNA, Messenger; Transcription Factors | 2017 |
Osthole, a Coumadin Analog from Cnidium monnieri (L.) Cusson, Ameliorates Nucleus Pulposus-Induced Radicular Inflammatory Pain by Inhibiting the Activation of Extracellular Signal-Regulated Kinase in Rats.
Topics: Analgesics; Animals; Blotting, Western; Cnidium; Coumarins; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Intervertebral Disc Displacement; Male; Nucleus Pulposus; Pain; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2017 |
Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways.
Topics: Animals; Blotting, Western; Colitis; Coumarins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Signal Transduction; Trinitrobenzenesulfonic Acid | 2017 |
Potent
Topics: Antifungal Agents; Candida albicans; Candidiasis; Coumarins; Drug Resistance, Fungal; Drug Synergism; Drug Therapy, Combination; Fluconazole; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Oxidative Stress; Reactive Oxygen Species | 2017 |
Plant-derived antifungal compounds trigger a common transcriptional response.
Topics: Antifungal Agents; Biphenyl Compounds; Coumarins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Lignans; Oxidative Stress; Plant Extracts; Resveratrol; Schizosaccharomyces; Stilbenes; Transcription, Genetic; Up-Regulation | 2017 |
Osthole Enhances Osteogenesis in Osteoblasts by Elevating Transcription Factor Osterix via cAMP/CREB Signaling In Vitro and In Vivo.
Topics: Alkaline Phosphatase; Animals; Calcium Channel Blockers; Cell Line; Cell Proliferation; Cell Survival; Coumarins; CREB-Binding Protein; Cyclic AMP; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Osteoblasts; Osteogenesis; Sp7 Transcription Factor | 2017 |
Osthole inhibits intimal hyperplasia by regulating the NF-κB and TGF-β1/Smad2 signalling pathways in the rat carotid artery after balloon injury.
Topics: Animals; Carotid Artery Injuries; Carotid Artery, Common; Coumarins; Gene Expression Regulation; Hyperplasia; Male; Neointima; NF-kappa B; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Time Factors; Transforming Growth Factor beta1 | 2017 |
Osthole Enhances the Therapeutic Efficiency of Stem Cell Transplantation in Neuroendoscopy Caused Traumatic Brain Injury.
Topics: Animals; Brain Injuries, Traumatic; Coumarins; Male; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neuroendoscopy; Stem Cell Transplantation | 2017 |
Osthole attenuates pulmonary arterial hypertension in monocrotaline‑treated rats.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Coumarins; Disease Models, Animal; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NF-kappa B; Organ Size; Pulmonary Artery; Rats, Sprague-Dawley | 2017 |
Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coumarins; Epigenesis, Genetic; Histones; Humans; Male; Mice; Mice, Nude; Osteogenesis; Periodontal Ligament; Periodontitis; Rats; Rats, Sprague-Dawley; Stem Cells; Young Adult | 2017 |
Osthole protects against inflammation in a rat model of chronic kidney failure via suppression of nuclear factor-κB, transforming growth factor-β1 and activation of phosphoinositide 3-kinase/protein kinase B/nuclear factor (erythroid-derived 2)-like 2 sig
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Biopsy; Chemokine CCL2; Coumarins; Cytokines; Disease Models, Animal; Gene Expression Regulation; Histocytochemistry; Inflammation Mediators; Kidney Failure, Chronic; Kidney Function Tests; Male; NF-E2-Related Factor 2; NF-kappa B; Phosphatidylinositol 3-Kinases; Rats; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Antifungal activity of osthol in vitro and enhancement in vivo through Eudragit S100 nanocarriers.
Topics: Administration, Oral; Animals; Antifungal Agents; Candida albicans; Candidiasis; Coumarins; Disease Models, Animal; Drug Carriers; Drug Synergism; Fluconazole; Mice; Plasma; Polymethacrylic Acids; Treatment Outcome | 2018 |
In vitro anticancer activities of osthole against renal cell carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coumarins; Down-Regulation; Epithelial-Mesenchymal Transition; Humans; Kidney Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Signal Transduction; Up-Regulation | 2017 |
Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury.
Topics: Animals; Behavior, Animal; Brain Injuries; Cell Proliferation; Cell Survival; Cognitive Dysfunction; Coumarins; Maze Learning; Mice, Inbred C57BL; Neural Stem Cells; Receptor, Notch1; RNA, Messenger; Signal Transduction; Transcription Factor HES-1; Up-Regulation | 2018 |
Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cholangiocarcinoma; Coumarins; Male; Membrane Potential, Mitochondrial; Mice, Nude; Mitochondria; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Tumor Stem Cell Assay | 2017 |
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes.
Topics: Animals; Bone Morphogenetic Proteins; Chondrocytes; Coumarins; Fracture Healing; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Osteogenesis; Signal Transduction; Tibial Fractures | 2017 |
[Effect of wintergreen oil on in vitro transdermal permeation of osthole and geniposide].
Topics: Administration, Cutaneous; Animals; Coumarins; Iridoids; Oils, Volatile; Plant Extracts; Rats; Salicylates; Skin; Skin Absorption | 2017 |
Osthole attenuates right ventricular remodeling via decreased myocardial apoptosis and inflammation in monocrotaline-induced rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Pressure; Caspase 3; Coumarins; Gene Expression Regulation; Heart Ventricles; I-kappa B Proteins; Interleukin-6; Male; Monocrotaline; Myocardium; Phosphorylation; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2018 |
Combination of Osthole and Cisplatin Against Rhabdomyosarcoma TE671 Cells Yielded Additive Pharmacologic Interaction by Means of Isobolographic Analysis.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Coumarins; Drug Synergism; Humans; Rhabdomyosarcoma | 2018 |
Osthole induces human nasopharyngeal cancer cells apoptosis through Fas-Fas ligand and mitochondrial pathway.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Caspases; Cell Line, Tumor; Cell Proliferation; Coumarins; Fas Ligand Protein; fas Receptor; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2018 |
Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Coumarins; Enzyme-Linked Immunosorbent Assay; Heme Oxygenase-1; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Medicine, Chinese Traditional; Mice; Microglia; NF-E2-Related Factor 2; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2018 |
Therapeutic efficacy of osthole against dinitrobenzene sulphonic acid induced-colitis in rats.
Topics: Animals; Antioxidants; Benzenesulfonates; Colitis; Coumarins; Cytokines; Disease Models, Animal; Male; Oxidative Stress; Rats, Sprague-Dawley | 2018 |
Identification of Functional Food Factors as β
Topics: Adrenergic beta-2 Receptor Agonists; Alkaloids; Animals; Coumarins; CREB-Binding Protein; Cyclic AMP; Functional Food; Gene Expression Regulation; HEK293 Cells; Humans; Indole Alkaloids; Injections, Intramuscular; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Receptors, Adrenergic, beta-2; Tyramine | 2018 |
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Coumarins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; G2 Phase; Humans; Mitosis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction | 2018 |
Comparative metabolites profiles of osthole in normal and osteoporosis rats using liquid chromatography quadrupole time-of-flight mass spectrometry.
Topics: Administration, Oral; Animals; Coumarins; Female; Mass Spectrometry; Metabolic Networks and Pathways; Osteoporosis; Plasma; Rats; Rats, Wistar | 2018 |
Osthole inhibits gastric cancer cell proliferation through regulation of PI3K/AKT.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Coumarins; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; M Phase Cell Cycle Checkpoints; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Stomach Neoplasms | 2018 |
Global Proteomics Deciphered Novel-Function of Osthole Against Pulmonary Arterial Hypertension.
Topics: Animals; Arterial Pressure; Coumarins; Disease Progression; Drug Discovery; Gene Expression Regulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Proteomics; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Vascular Remodeling | 2018 |
Osthole ameliorates neurogenic and inflammatory hyperalgesia by modulation of iNOS, COX-2, and inflammatory cytokines in mice.
Topics: Angelica; Animals; Behavior, Animal; Cnidium; Coumarins; Cyclooxygenase 2 Inhibitors; Cytokines; Enzyme Inhibitors; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Nitric Oxide Synthase Type II; Pain Management; Plants, Medicinal | 2019 |
Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Movement; Cell Proliferation; Coumarins; Hindlimb; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synoviocytes; Tumor Necrosis Factor-alpha | 2018 |
Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Coumarins; Crystallization; Drug Delivery Systems; Drug Evaluation, Preclinical; Emulsifying Agents; Emulsions; Excipients; Male; Particle Size; Polyethylene Glycols; Rabbits; Solubility | 2018 |
The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice.
Topics: Analysis of Variance; Animals; Bone Resorption; Cathepsin K; Cell Survival; Coumarins; Drug Discovery; Female; Humans; Injections, Intraperitoneal; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Osteoporosis, Postmenopausal; Ovariectomy; Proto-Oncogene Proteins c-fos; RANK Ligand; Signal Transduction; Tartrate-Resistant Acid Phosphatase | 2018 |
Osthole Delays Tert-Butyl Hydroperoxide-Induced Premature Senescence in Neural Stem Cells.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cell Cycle; Cells, Cultured; Cellular Senescence; Coumarins; Mice; Neural Stem Cells; Signal Transduction; tert-Butylhydroperoxide | 2018 |
Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF‑κB signaling.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Cnidium; Coumarins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Female; Humans; NF-kappa B; Radiation Tolerance; Signal Transduction; Uterine Cervical Neoplasms | 2018 |
Osthole Protects against Acute Lung Injury by Suppressing NF-
Topics: Active Transport, Cell Nucleus; Acute Lung Injury; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Coumarins; Enzyme-Linked Immunosorbent Assay; Inflammation; Lung Injury; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; NF-kappa B; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2018 |
Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Polarity; Coumarins; Disease Progression; Down-Regulation; Female; Immunologic Factors; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Pancreatic Neoplasms; RAW 264.7 Cells; STAT6 Transcription Factor; Tumor Microenvironment | 2018 |
Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin.
Topics: Animals; Antipruritics; Calcium Channel Blockers; Cell Line; Coumarins; HEK293 Cells; Humans; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus; Signal Transduction; Skin; TRPV Cation Channels | 2018 |
[Effects of Osthole on Apoptosis of HL-60 Cells Induced by TRAIL and Its Related Mechanism].
Topics: Apoptosis; Coumarins; HL-60 Cells; Humans; TNF-Related Apoptosis-Inducing Ligand | 2018 |
Osthole alleviated diabetic neuropathic pain mediated by the P2X
Topics: Analgesics; Animals; Coumarins; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; Neuralgia; Pain Threshold; Purinergic P2X Receptor Antagonists; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P2X4; Up-Regulation | 2018 |
Synthesis and Biological Evaluation of Novel Osthol Derivatives as Potent Cytotoxic Agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Coumarins; Humans; Membrane Potential, Mitochondrial | 2019 |
Osthole prevents tamoxifen-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Coumarins; Cytokines; Dose-Response Relationship, Drug; Estrogen Receptor Modulators; Hydrogen Peroxide; Inflammation; Liver; Male; Malondialdehyde; Mice, Inbred BALB C; Oxidative Stress; Tamoxifen | 2019 |
Osthole alleviates oxidized low-density lipoprotein-induced vascular endothelial injury through suppression of transforming growth factor-β1/Smad pathway.
Topics: Atherosclerosis; Cell Survival; Coumarins; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Vascular Cell Adhesion Molecule-1 | 2018 |
Effects of Osthol Isolated from
Topics: Cell Line; Chemical Fractionation; Cnidium; Coumarins; Fruit; Humans; Kinetics; Organic Anion Transporters; Plant Extracts | 2018 |
Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apoptosis; Coumarins; Glycogen Synthase Kinase 3 beta; Hippocampus; Memory; Mice, Inbred C57BL; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; tau Proteins | 2019 |
Osthole inhibits triple negative breast cancer cells by suppressing STAT3.
Topics: Animals; Apiaceae; Apoptosis; Coumarins; Female; Humans; Mice; STAT3 Transcription Factor; Triple Negative Breast Neoplasms | 2018 |
Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes.
Topics: Animals; Coumarins; Cytokines; Gene Silencing; Hepatocytes; Inflammation Mediators; Lipid Metabolism; Lipopolysaccharides; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oleic Acid; PPAR alpha; Rats; Signal Transduction | 2019 |
Osthole alleviates MPTP-induced Parkinson's disease mice by suppressing Notch signaling pathway.
Topics: Adjuvants, Immunologic; Animals; Coumarins; Male; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; Oxidative Stress; PC12 Cells; Random Allocation; Rats; Receptors, Notch; Signal Transduction | 2019 |
Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action.
Topics: Antigens, Neoplasm; Cell Cycle; Cell Line; Coumarins; Diabetic Nephropathies; Glucuronidase; Glycation End Products, Advanced; Humans; Hypertrophy; Janus Kinase 2; Kidney Tubules; Klotho Proteins; Mitogen-Activated Protein Kinases; STAT3 Transcription Factor; Suppressor of Cytokine Signaling Proteins | 2019 |
[Osthole suppresses amyloid precursor protein expression by up-regulating miRNA-101a-3p in Alzheimer's disease cell model].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Coumarins; Gene Expression Regulation; Humans; MicroRNAs | 2018 |
Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Blotting, Western; Cell Line; Coumarins; Dexamethasone; Esculin; Glucocorticoids; Hypoglycemic Agents; Male; Mice; Mice, Inbred ICR; Muscle, Skeletal; Proto-Oncogene Proteins c-akt; Signal Transduction | 2019 |
Osthole attenuates mouse atopic dermatitis by inhibiting thymic stromal lymphopoietin production from keratinocytes.
Topics: Adjuvants, Immunologic; Animals; CD4-Positive T-Lymphocytes; Coumarins; Cytokines; Dermatitis, Atopic; Enzyme-Linked Immunosorbent Assay; Interleukin-13; Interleukin-4; Keratinocytes; Mice; Mice, Inbred BALB C; Th1 Cells; Th17 Cells; Thymic Stromal Lymphopoietin | 2019 |
Osthole induced apoptosis in human normal liver cells by regulating cell proliferation and endoplasmic reticulum stress.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Culture Techniques; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cell Survival; Coumarins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Liver | 2019 |
Discovery of a potential MCR-1 inhibitor that reverses polymyxin activity against clinical mcr-1-positive Enterobacteriaceae.
Topics: Animals; Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Coumarins; Disease Models, Animal; Drug Resistance, Bacterial; Drug Synergism; Enzyme Inhibitors; Escherichia coli Infections; Ethanolaminephosphotransferase; Female; Klebsiella Infections; Mice, Inbred BALB C; Microbial Sensitivity Tests; Microbial Viability; Molecular Docking Simulation; Polymyxins; Treatment Outcome | 2019 |
The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways.
Topics: Animals; Anti-Inflammatory Agents; Cnidium; Colitis, Ulcerative; Coumarins; Dinoprostone; Disease Models, Animal; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; RAW 264.7 Cells; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Osthole inhibits proliferation and induces apoptosis in BV-2 microglia cells in kainic acid-induced epilepsy via modulating PI3K/AKt/mTOR signalling way.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Coumarins; Kainic Acid; Mice; Microglia; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
RETRACTED: Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calcium Channel Blockers; Coumarins; Disease Models, Animal; Gene Expression Regulation; Humans; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Neuroblastoma; Presenilin-1; Tumor Cells, Cultured; Up-Regulation | 2019 |
A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole.
Topics: Anti-Inflammatory Agents; Autism Spectrum Disorder; Child; Child, Preschool; Coumarins; Cyclooxygenase 2; Female; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Infant; Leukocytes, Mononuclear; Male; Terfenadine | 2019 |
New insights into the binding mechanism between osthole and β-lactoglobulin: Spectroscopic, chemometrics and docking studies.
Topics: Adjuvants, Immunologic; Calcium Channel Blockers; Circular Dichroism; Coumarins; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Lactoglobulins; Molecular Docking Simulation; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2019 |
Osthole promotes the suppressive effects of cisplatin on NRF2 expression to prevent drug-resistant cervical cancer progression.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Coumarins; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Mice; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Osthole alleviates inflammation by down-regulating NF-κB signaling pathway in traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Cell Line; Coumarins; Cytokines; Down-Regulation; Inflammation; Mice; NF-kappa B; Signal Transduction | 2019 |
Use of anti-histamines and osthole in autistic children.
Topics: Anti-Inflammatory Agents; Autism Spectrum Disorder; Autistic Disorder; Child; Coumarins; Histamine; Humans; Hypersensitivity | 2019 |
Osthole improves therapy for osteoporosis through increasing autophagy of mesenchymal stem cells.
Topics: Animals; Autophagy; Calcium Channel Blockers; Coumarins; Female; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteoporosis | 2019 |
Osthole inhibits the progression of human gallbladder cancer cells through JAK/STAT3 signal pathway both in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coumarins; Gallbladder Neoplasms; Humans; Janus Kinases; Male; Mice, Inbred BALB C; Mice, Nude; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2019 |
Inhibition of the Warm Temperature-Activated Ca
Topics: Administration, Topical; Animals; Coumarins; Cymenes; Dermatitis, Atopic; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Humans; Interleukin-6; Male; Mice; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2019 |
Studies on the Neuroprotection of Osthole on Glutamate-Induced Apoptotic Cells and an Alzheimer's Disease Mouse Model via Modulation Oxidative Stress.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Coumarins; Disease Models, Animal; Glutamic Acid; Mice; Mice, Transgenic; Neuroprotection; NF-E2-Related Factor 2; Oxidative Stress; Presenilin-1; Signal Transduction | 2020 |
Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Coumarins; Disease Models, Animal; Disease Progression; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Fatty Acid Synthase, Type I; Fatty Liver; Female; Humans; Lipogenesis; Liver; Liver Neoplasms; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors | 2020 |
Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coumarins; Endoplasmic Reticulum Stress; Female; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Signal Transduction | 2019 |
Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Basic Helix-Loop-Helix Transcription Factors; Cartilage, Articular; Coumarins; Down-Regulation; Drug Evaluation, Preclinical; Humans; Iodoacetic Acid; Male; Mice; Mice, Inbred ICR; NF-kappa B; Osteoarthritis; Protective Agents; Signal Transduction | 2020 |
Osthole inhibits cell proliferation by regulating the TGF-β1/Smad/p38 signaling pathways in pulmonary arterial smooth muscle cells.
Topics: Animals; Becaplermin; Cell Proliferation; Coumarins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Male; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Tumor Suppressor Protein p53 | 2020 |
Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cnidium; Coumarins; Cyclin B1; G2 Phase Cell Cycle Checkpoints; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Squamous Cell Carcinoma of Head and Neck | 2020 |
[Isolation and identification of pathogen of Dendrobium officinale gray mold and its prevention and control].
Topics: Alkaloids; Botrytis; Coumarins; Dendrobium; Eugenol; Fungicides, Industrial; Matrines; Plant Diseases; Plant Leaves; Quinolizines | 2019 |
Inhibitory Effect of Osthole from
Topics: Antiviral Agents; Capsid Proteins; Cnidium; Coumarins; Kinetics; Nicotiana; Plant Diseases; Tobacco Mosaic Virus; Virion | 2019 |
Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo.
Topics: Animals; Area Under Curve; Coumarins; Cytochrome P-450 CYP3A; Gene Expression Regulation, Enzymologic; Liver; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2020 |
Osthole: A Traditional Chinese Medicine for Ocular Anti-Angiogenic Therapy.
Topics: Adjuvants, Immunologic; Angelica; Animals; Cells, Cultured; Cornea; Corneal Neovascularization; Coumarins; Disease Models, Animal; Humans; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR | 2020 |
Osthole relieves diabetics cardiac autonomic neuropathy associated with P2X3 receptor in ratstellate ganglia.
Topics: Animals; Blood Pressure; Coumarins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Ganglia; Male; Molecular Docking Simulation; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Streptozocin | 2020 |
Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Coumarins; Female; Humans; Microtubule-Associated Proteins; Ovarian Neoplasms; Reactive Oxygen Species; Receptors, Estrogen | 2020 |
Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST) inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in rats.
Topics: Animals; Bone Resorption; Cell Differentiation; Chitosan; Coumarins; Female; Humans; Mice; Micelles; NF-kappa B; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; RANK Ligand; Rats; RAW 264.7 Cells; Signal Transduction | 2020 |
Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol-induced osteonecrosis of the femoral head.
Topics: Adipogenesis; Animals; beta Catenin; Cell Differentiation; Coumarins; Ethanol; Femur Head; Femur Head Necrosis; Human Umbilical Vein Endothelial Cells; Humans; Male; Mesenchymal Stem Cells; Osteocalcin; Osteogenesis; Osteonecrosis; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2020 |
Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats.
Topics: Angelica; Animals; Aorta, Thoracic; Calcium; Coumarins; Drugs, Chinese Herbal; Endothelial Cells; In Vitro Techniques; Male; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2019 |
Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognitive Dysfunction; Coumarins; Disease Models, Animal; Humans; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons | 2021 |
[Effect of osthole on periodontal remodeling during orthodontic tooth movement in rats].
Topics: Animals; Bone Remodeling; Coumarins; Male; Molar; Osteoclasts; Periodontal Ligament; Rats; Rats, Sprague-Dawley; Tooth Movement Techniques | 2019 |
Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats.
Topics: Animals; Coumarins; Disease Models, Animal; Down-Regulation; Lysophospholipids; Male; MicroRNAs; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Sphingosine; TOR Serine-Threonine Kinases | 2020 |
Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer's Disease-Related Pathology in APP/PS-1 Mice.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Brain; Cell Line; Coumarins; Humans; Liposomes; Mice, Transgenic; Neurons; Neuroprotective Agents; Polyethylene Glycols; Presenilin-1; Rats, Sprague-Dawley; Tissue Distribution; Transferrin | 2020 |
Coumarins modulate the anti-glioma properties of temozolomide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Movement; Coumarins; Gene Expression Regulation, Neoplastic; Glioma; Humans; Membrane Potential, Mitochondrial; Necrosis; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Temozolomide | 2020 |
Application of natural products as insecticide candidates: Semisynthesis and biological evaluation of some novel osthole-based esters.
Topics: Angelica; Animals; Biological Products; Cell Line; Cell Survival; Citrus; Cnidium; Coumarins; Dose-Response Relationship, Drug; Insecticides; Lepidoptera; Molecular Structure; Rats; Structure-Activity Relationship | 2020 |
Ultrasound-assisted extraction extracts from Stemona japonica (Blume) Miq. and Cnidium monnieri (L.) Cuss. could be used as potential Rhipicephalus sanguineus control agents.
Topics: Animals; Biological Assay; Cnidium; Coumarins; Furaldehyde; Gas Chromatography-Mass Spectrometry; Molting; Nicotiana; Nymph; Plant Extracts; Rabbits; Rhipicephalus sanguineus; Stemonaceae; Tick Control | 2020 |
The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies.
Topics: Catalytic Domain; Citrus paradisi; Coumarins; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Furocoumarins; Heme; Humans; Hydrogen Bonding | 2020 |
Osthole resensitizes CD133
Topics: AC133 Antigen; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cisplatin; Coumarins; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Oncogene Protein v-akt; Phosphorylation; PTEN Phosphohydrolase; Signal Transduction; Xenograft Model Antitumor Assays | 2020 |
Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Coumarins; Endoplasmic Reticulum; Female; Humans; Mitochondria; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Phosphatidylinositol 3-Kinase; Signal Transduction; Tumor Microenvironment; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays; Zebrafish | 2021 |
Osthole attenuates ovalbumin‑induced lung inflammation via the inhibition of IL‑33/ST2 signaling in asthmatic mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Coumarins; Disease Models, Animal; Drugs, Chinese Herbal; Female; Gene Expression Regulation; Inflammation; Interferon-gamma; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Interleukins; Lung; Lymphocyte Count; Mice; Mice, Inbred BALB C; Ovalbumin; Phytotherapy; Pulmonary Eosinophilia; Random Allocation; RNA, Messenger; Signal Transduction | 2020 |
Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Coumarins; Liposomes; Mice | 2021 |
Construction of oxime ester derivatives of osthole from Cnidium monnieri, and evaluation of their agricultural activities and control efficiency.
Topics: Animals; Cnidium; Coumarins; Molecular Structure; Oximes | 2020 |
Osthole Reduces Mouse IOP Associated With Ameliorating Extracellular Matrix Expression of Trabecular Meshwork Cell.
Topics: Animals; Blotting, Western; Cells, Cultured; Collagen Type IV; Coumarins; Extracellular Matrix; Fibronectins; Humans; Intraocular Pressure; Laminin; Male; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; Trabecular Meshwork; Transforming Growth Factor beta2 | 2020 |
Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation.
Topics: Animals; Behavior, Animal; Brain; Coumarins; Cytokines; Depression; Drug Therapy, Combination; Female; Maze Learning; Mice; Oxidative Stress; Pain; Pain Threshold; Reserpine; Serotonin; Umbelliferones | 2021 |
Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition via Inhibition NLRP3 Inflammasome.
Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Behavior Observation Techniques; Behavior, Animal; Brain; Cognitive Dysfunction; Coumarins; Dementia, Vascular; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inflammasomes; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats | 2020 |
Osthole inhibits proliferation of kainic acid‑activated BV‑2 cells by modulating the Notch signaling pathway.
Topics: Animals; Cell Line, Transformed; Cell Proliferation; Cnidium; Coumarins; Drugs, Chinese Herbal; Epilepsy; Kainic Acid; Mice; Microglia; Receptors, Notch; Signal Transduction | 2020 |
The neuroprotective effect of osthole against chronic sleep deprivation (CSD)-induced memory impairment in rats.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Coumarins; Disease Models, Animal; Male; Memory Disorders; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Sleep Deprivation | 2020 |
The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2.
Topics: Activating Transcription Factor 4; Alkaloids; Animals; Antiviral Agents; Apoptosis; Caspase 3; Cell Line; Circovirus; Coumarins; Drug Combinations; Drug Synergism; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Epithelial Cells; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Heat-Shock Proteins; Host-Pathogen Interactions; Kidney; Matrines; Proto-Oncogene Proteins c-bcl-2; Quinolizines; Signal Transduction; Swine; Transcription Factor CHOP; Viral Proteins | 2020 |
Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coumarins; Drug Design; Humans; Molecular Docking Simulation; Neuroprotective Agents; Peptide Fragments; Structure-Activity Relationship | 2020 |
Antiglioma Potential of Coumarins Combined with Sorafenib.
Topics: 4-Hydroxycoumarins; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Line, Tumor; Cell Proliferation; Coumarins; Esculin; Gene Expression Regulation; Glioblastoma; Humans; Magnoliopsida; Necrosis; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; raf Kinases; RNA, Small Interfering; Sorafenib; Umbelliferones | 2020 |
Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.
Topics: Animals; Asthma; Coumarins; Drugs, Chinese Herbal; Humans; Lung; Mice; Myocytes, Smooth Muscle; Phosphorylation; Signal Transduction | 2020 |
The Use of 1H-qNMR Method for Simultaneous Determination of Osthol, Columbianadin, and Isoimperatorin in Angelicae Pubescentis Radix.
Topics: Angelica; Coumarins; Furocoumarins | 2020 |
Osthole induces necroptosis via ROS overproduction in glioma cells.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Coumarins; Drug Screening Assays, Antitumor; Glioma; Humans; Leupeptins; Membrane Potential, Mitochondrial; Mitochondria; Necroptosis; Reactive Oxygen Species | 2021 |
Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Coumarins; Drug Synergism; Furocoumarins; Humans; Melanoma; Methoxsalen | 2021 |
Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Cell Line, Tumor; Cell Survival; Choline; Coumarins; Cytoprotection; Drug Liberation; Emulsions; Glutamic Acid; Lipids; Memory; Mice; Nanoparticles; Oxidative Stress; Particle Size; Phase Transition; Scopolamine; Solubility; Static Electricity; Surface-Active Agents; Water | 2021 |
Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet.
Topics: Animals; Coumarins; Diet, Carbohydrate Loading; Diet, High-Fat; Diet, Western; Fructokinases; Fructose; Kidney Diseases; Male; Metabolic Syndrome; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Rats; Rats, Wistar | 2021 |
Regioselective hemisynthesis and insecticidal activity of C8-hydrazones/acylhydrazones/sulfonylhydrazones coumarin-type derivatives of osthole.
Topics: Animals; Coumarins; Hydrazones; Insecticides; Molecular Structure; Moths; Toxicity Tests | 2021 |
Investigation on drug entrapment location in liposomes and transfersomes based on molecular dynamics simulation.
Topics: Coumarins; Drug Carriers; Fluorouracil; Liposomes; Molecular Dynamics Simulation; Pyrazines; Solubility | 2021 |
Osthole enhances the immunosuppressive effects of bone marrow-derived mesenchymal stem cells by promoting the Fas/FasL system.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Cells, Cultured; Colitis; Coumarins; Estrogens; Fas Ligand Protein; fas Receptor; Female; Immune Tolerance; Immunomodulation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteoporosis | 2021 |
Osthole improves pulmonary artery hypertension by inducing apoptosis in pulmonary artery smooth muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; bcl-2-Associated X Protein; Calcium Channel Blockers; Caspase 3; Coumarins; Disease Models, Animal; Hypertension, Pulmonary; Lung; MAP Kinase Kinase Kinase 5; Myocytes, Smooth Muscle; Organ Size; Pulmonary Artery; Rats; Signal Transduction; Treatment Outcome; Up-Regulation | 2021 |
Simple Osthole/Nanocarrier Pesticide Efficiently Controls Both Pests and Diseases Fulfilling the Need of Green Production of Strawberry.
Topics: Animals; Antifungal Agents; Aphids; Coumarins; Dendrimers; Drug Carriers; Fragaria; Insecticides; Sf9 Cells; Spodoptera; Tetranychidae | 2021 |
Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Coumarins; Female; Humans; Neoplasm Invasiveness; Zebrafish | 2022 |
Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
Topics: Coumarins; Humans; Keratinocytes; Skin; TRPV Cation Channels | 2021 |
[Effects of Osthole on Apoptosis and Autophagy of Human Tongue Cancer Tca8113 Cells].
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Coumarins; Humans; Tongue Neoplasms | 2021 |
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Differentiation; Cell Proliferation; Coumarins; Disease Models, Animal; Humans; Idiopathic Pulmonary Fibrosis; Lung; Male; Mice; Mice, Inbred C57BL; Myofibroblasts; NADPH Oxidase 4; Oxidative Stress; Reactive Oxygen Species; Smad3 Protein; Survival Rate; Transforming Growth Factor beta1 | 2021 |
Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma.
Topics: Animals; Antifungal Agents; Biological Availability; Coumarins; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Herb-Drug Interactions; Ketoconazole; Lignans; Male; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley | 2022 |
DCLK1 might be a therapeutic target of osthole against cervical cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Coumarins; Doublecortin-Like Kinases; Female; Humans; Intracellular Signaling Peptides and Proteins; Molecular Docking Simulation; Protein Serine-Threonine Kinases; Uterine Cervical Neoplasms | 2021 |
Osthole alleviates pulmonary vascular remodeling by modulating microRNA-22-3p mediated lipid metabolic reprogramming.
Topics: Animals; Cell Proliferation; Coumarins; Disease Models, Animal; Lipids; MicroRNAs; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2022 |
Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coumarins; Cyclobutanes; Humans; Organoplatinum Compounds; Transcriptome; Tumor Suppressor Protein p53 | 2021 |
Effects of Osthole on Inflammatory Gene Expression and Cytokine Secretion in Histamine-Induced Inflammation in the Caco-2 Cell Line.
Topics: Anti-Inflammatory Agents; Caco-2 Cells; Coumarins; Cytokines; Histamine; Humans; Inflammation | 2021 |
Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis.
Topics: Cells, Cultured; Chemokines; Coumarins; Cyclooxygenase 2; Dermatitis, Atopic; Epidermis; Gene Expression Regulation; Histamine; Humans; Inflammation; Lipopolysaccharides; Male; Models, Biological; Signal Transduction; Tight Junctions; Toll-Like Receptor 2 | 2021 |
Design and synthesis of Osthole-based compounds as potential Nrf2 agonists.
Topics: Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; NF-E2-Related Factor 2; Structure-Activity Relationship | 2022 |
Osthole Exerts Inhibitory Effects on Hypoxic Colon Cancer Cells via EIF2[Formula: see text] Phosphorylation-mediated Apoptosis and Regulation of HIF-1[Formula: see text].
Topics: Apoptosis; Cell Hypoxia; Colonic Neoplasms; Coumarins; Eukaryotic Initiation Factor-2; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Phosphorylation; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2022 |
Protective effect of osthole on testicular ischemia/reperfusion injury in rats.
Topics: Animals; Coumarins; Ischemia; Male; Rats; Rats, Wistar; Reperfusion Injury; Testis | 2022 |
Osthole Increases the Sensitivity of Liver Cancer to Sorafenib by Inhibiting Cholesterol Metabolism.
Topics: Animals; Cholesterol; Coumarins; Liver; Liver Neoplasms; Mice; Sorafenib; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2 | 2022 |
Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Coumarins; HeLa Cells; Humans; NAD(P)H Dehydrogenase (Quinone); Proteomics; Pyroptosis; Reactive Oxygen Species; Receptors, Estrogen | 2022 |
Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives.
Topics: Amides; Animals; Aphids; Biological Products; Coumarins; Esters; Molecular Structure; Pesticides; Structure-Activity Relationship; Tetranychidae | 2022 |
Imidacloprid Impairs Glutamatergic Synaptic Plasticity and Desensitizes Mechanosensitive, Nociceptive, and Photogenic Response of
Topics: Animals; Coumarins; Drosophila; Drosophila melanogaster; Drosophila Proteins; Neonicotinoids; Neuronal Plasticity; Nitro Compounds; Nociception; Oxidative Stress; Receptors, Glutamate | 2022 |
The coumarin osthole is a non-electrophilic agonist of TRPA1.
Topics: Animals; Antipruritics; Calcium; Coumarins; Cymenes; Ganglia, Spinal; HEK293 Cells; Humans; Menthol; Mice; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
[The effect of osthole on lipopolysaccharide-induced macrophages polarization and inflammatory reaction].
Topics: Coumarins; Humans; Inflammation; Interleukin-10; Lipopolysaccharides; Macrophages; Reactive Oxygen Species; Receptors, CCR7; Tumor Necrosis Factor-alpha | 2022 |
Errata: Osthole improves therapy for osteoporosis through increasing autophagy of mesenchymal stem cells.
Topics: Animals; Autophagy; Coumarins; Humans; Mesenchymal Stem Cells; Osteoporosis | 2022 |
Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis.
Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Glycogen Synthase Kinase 3 beta; Glycolysis; Humans; Lactic Acid; Liver Neoplasms; Radiation Tolerance; Signal Transduction; TOR Serine-Threonine Kinases | 2023 |
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cells, Cultured; Coumarins; Fibroblasts; Inflammasomes; Inflammation; Molecular Docking Simulation; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Synovial Membrane; Tumor Necrosis Factor-alpha | 2023 |
Osthole Alleviates D-Galactose-Induced Liver Injury
Topics: Chemical and Drug Induced Liver Injury, Chronic; Coumarins; Galactose; Humans; Liver; NF-kappa B; Toll-Like Receptor 4 | 2023 |
UPLC-Q-TOF/MS-Based Metabolomics Approach Reveals Osthole Intervention in Breast Cancer 4T1 Cells.
Topics: Biomarkers; Breast Neoplasms; Coumarins; Female; Humans; Metabolomics; TOR Serine-Threonine Kinases | 2023 |
Osthole Antagonizes Microglial Activation in an NRF2-Dependent Manner.
Topics: Animals; Cell Line; Coumarins; Drosophila; Lipopolysaccharides; Mice; Microglia; NF-E2-Related Factor 2 | 2023 |
Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites.
Topics: Cell Proliferation; Coumarins; Fungi; Humans; Molecular Structure | 2023 |
Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling.
Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Coumarins; Ferroptosis; Humans; Phenotype; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); TOR Serine-Threonine Kinases | 2023 |
Biosynthesis of the Plant Coumarin Osthole by Engineered
Topics: Coumarins; Fermentation; Metabolic Engineering; Saccharomyces cerevisiae; Signal Transduction | 2023 |
Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway.
Topics: Apoptosis; Autophagy; Coumarins; Humans; MAP Kinase Signaling System; Molecular Docking Simulation; Myocytes, Cardiac; TOR Serine-Threonine Kinases; Trastuzumab | 2023 |
Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains.
Topics: Coumarins; COVID-19; Furin; Humans; SARS-CoV-2 | 2023 |