nnc 112 and benzofurans
nnc 112 has been researched along with benzofurans in 30 studies
Compound Research Comparison
| Studies (nnc 112) | Trials (nnc 112) | Recent Studies (post-2010) (nnc 112) | Studies (benzofurans) | Trials (benzofurans) | Recent Studies (post-2010) (benzofurans) |
|---|---|---|---|---|---|
| 32 | 3 | 7 | 13,293 | 451 | 4,970 |
Research
Studies (30)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 15 (50.00) | 29.6817 |
| 2010's | 9 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wachtel, SR; White, FJ | 1 |
| Andersen, PH; Nielsen, EB | 1 |
| Andersen, PH; Braestrup, C; Grønvald, FC; Guddal, E; Hansen, LB; Hohlweg, R; Nielsen, EB | 1 |
| Chou, YH; Farde, L; Foged, C; Halldin, C; Karlsson, P; Sandell, J; Sedvall, G; Swahn, CG | 1 |
| Chou, YH; Farde, L; Halldin, C; Karlsson, P; Olsson, H | 1 |
| Gerlach, J; Jensen, G; Nicholson, K; Peacock, L | 1 |
| Abi-Dargham, A; Anjilvel, S; Foged, C; Guo, NN; Halldin, C; Hwang, DR; Laruelle, M; Lombardo, I; Mann, JJ; Martinez, D; Mawlawi, O; Pidcock, J; Simpson, N; Slifstein, M; Van Heertum, R | 1 |
| Laruelle, M; Slifstein, M | 1 |
| Abi-Dargham, A; Gil, R; Gorman, JM; Huang, Y; Hwang, DR; Keilp, J; Kochan, L; Laruelle, M; Lombardo, I; Martinez, D; Mawlawi, O; Van Heertum, R | 1 |
| Abi-Dargham, A; Guo, N; Huang, YY; Hwang, DR; Laruelle, M; Lo, ES | 1 |
| Cumming, P; Doudet, DJ; Rosa-Neto, P | 1 |
| Domino, EF; Fukumoto, D; Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H | 1 |
| Domino, EF; Fukumoto, D; Kakiuchi, T; Miyasato, K; Nishiyama, S; Tsukada, H | 1 |
| Abi-Dargham, A; Cooper, TB; Frankle, WG; Gil, R; Huang, Y; Hwang, DR; Keefe, R; Kegeles, LS; Khenissi, L; Laruelle, M; Martinez, D; Narendran, R; Slifstein, M; Talbot, PS | 1 |
| Cropley, VL; Fujita, M; Ghose, S; Hong, J; Innis, RB; Musachio, JL; Nathan, PJ; Pike, VW; Sangare, J | 1 |
| Chou, YH; Farde, L; Halldin, C | 1 |
| Abi-Dargham, A; Frankle, WG; Gonzales, R; Kegeles, LS; Laruelle, M; Slifstein, M; Xu, X | 1 |
| Abi-Dargham, A; Cheng, B; Duvall, M; Frankle, WG; Kolachana, B; Laruelle, M; Simpson, EH; Slifstein, M; Tabares, P; Weinberger, DR | 1 |
| Bara-Jimenez, W; Brown, AK; Cropley, VL; Fujita, M; Hallett, M; Herscovitch, P; Innis, RB; Nathan, PJ; Pike, VW; Sangare, J; Zhang, XY | 1 |
| Cannon, DM; Drevets, WC; Erickson, K; Klaver, JM; Peck, SA; Rallis-Voak, D | 1 |
| Abi-Dargham, A; Broft, A; Fischman, MW; Foltin, RW; Hwang, DR; Kleber, HD; Laruelle, M; Martinez, D; Narendran, R; Perez, A; Slifstein, M | 1 |
| Bullich, S; Catafau, AM; Farre, M; Gunn, RN; Herance, R; Laruelle, M; Rabiner, EA; Radua, J; Searle, GE | 1 |
| Fujimura, Y; Ito, H; Kishimoto, T; Kosaka, J; Matsumoto, R; Nozaki, S; Okubo, Y; Suhara, T; Takahashi, H; Takano, A; Yasuno, F | 1 |
| Abi-Dargham, A; Gil, R; Hwang, DR; Kegeles, LS; Laruelle, M; Narendran, R; Slifstein, M; Thompson, JL; Urban, N; Xu, X | 1 |
| Abi-Dargham, A; Girgis, RR; Poels, EM; Slifstein, M; Thompson, JL | 1 |
| Bang-Andersen, B; Christoffersen, CT; Farde, L; Finnema, SJ; Gulyás, B; Halldin, C; Jørgensen, M; Wikström, HV | 1 |
| Flores, HP; Karimi, M; Moerlein, SM; Perlmutter, JS; Su, Y; Videen, TO | 1 |
| Alexoff, D; Carter, P; Fowler, JS; Kang, Y; Kim, D; Kim, SW; King, P; Logan, J; Muench, L; Shea, C; Skolnick, P; Volkow, ND | 1 |
| Aisaborhale, E; Borra, RH; Granda, ML; Guimaraes, AR; Hooker, JM; Schauer, N; Schroeder, FA | 1 |
| Bilder, R; Borg, J; Brown, AK; Cannon, T; Ghahremani, DG; Ishibashi, K; London, ED; Mandelkern, MA; Robertson, CL; Sabb, F | 1 |
Trials
3 trial(s) available for nnc 112 and benzofurans
| Article | Year |
|---|---|
Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility.
Topics: Adult; Artifacts; Benzazepines; Benzofurans; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Dopamine Antagonists; Female; Humans; Kinetics; Male; Middle Aged; Neocortex; Radioligand Assay; Receptors, Dopamine D1; Reproducibility of Results; Tomography, Emission-Computed | 2000 |
Prefrontal dopamine D1 receptors and working memory in schizophrenia.
Topics: Adult; Age Factors; Benzazepines; Benzofurans; Binding, Competitive; Carbon Radioisotopes; Dopamine Antagonists; Female; Humans; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Predictive Value of Tests; Prefrontal Cortex; Principal Component Analysis; Receptors, Dopamine D1; Schizophrenia; Tomography, Emission-Computed | 2002 |
Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans.
Topics: Adult; Benzazepines; Benzofurans; Female; Humans; Male; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Radiation Dosage; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D1; Tissue Distribution; Whole Body Imaging; Whole-Body Counting | 2006 |
Other Studies
27 other study(ies) available for nnc 112 and benzofurans
| Article | Year |
|---|---|
The effect of continuous and repeated administration of D1 dopamine receptor antagonist on midbrain dopamine neurons.
Topics: Animals; Benzazepines; Benzofurans; Dopamine; Dopamine Antagonists; Male; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 | 1992 |
Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists.
Topics: Amphetamine; Animals; Behavior, Animal; Benzazepines; Benzofurans; Catalepsy; Dopamine; Male; Mice; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior | 1992 |
NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists.
Topics: Animals; Benzazepines; Benzofurans; Dopamine; Dopamine D2 Receptor Antagonists; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Serotonin | 1992 |
Carbon-11-NNC 112: a radioligand for PET examination of striatal and neocortical D1-dopamine receptors.
Topics: Adult; Animals; Benzazepines; Benzofurans; Binding, Competitive; Carbon Radioisotopes; Corpus Striatum; Dopamine Antagonists; Humans; Kinetics; Macaca fascicularis; Male; Neocortex; Radioligand Assay; Receptors, Dopamine D1; Sensitivity and Specificity; Stereoisomerism; Tomography, Emission-Computed | 1998 |
A PET study of D(1)-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain.
Topics: Algorithms; Amphetamine; Animals; Benzazepines; Benzofurans; Brain; Brain Chemistry; Cerebellum; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Ligands; Macaca fascicularis; Neocortex; Neostriatum; Receptors, Dopamine D1; Reserpine; Tomography, Emission-Computed | 1999 |
Extrapyramidal side effects during chronic combined dopamine D1 and D2 antagonist treatment in Cebus apella monkeys.
Topics: Animals; Basal Ganglia Diseases; Benzazepines; Benzofurans; Cebus; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Male; Raclopride; Receptors, Dopamine D1; Time Factors | 1999 |
Effects of statistical noise on graphic analysis of PET neuroreceptor studies.
Topics: Animals; Artifacts; Benzazepines; Benzofurans; Brain; Dopamine Antagonists; Humans; Models, Theoretical; Papio; Piperazines; Pyridines; Receptors, Dopamine D1; Receptors, Serotonin; Serotonin Antagonists; Statistics as Topic; Tomography, Emission-Computed | 2000 |
Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia.
Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Benzazepines; Benzofurans; Binding Sites; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; Hippocampus; Male; Prefrontal Cortex; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Schizophrenia; Time Factors; Tritium | 2003 |
Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET.
Topics: Animals; Benzazepines; Benzofurans; Binding Sites; Brain Mapping; Carbon Isotopes; Corpus Striatum; Dopamine Antagonists; Macaca mulatta; Male; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Swine; Swine, Miniature; Tissue Distribution; Tomography, Emission-Computed | 2004 |
Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys.
Topics: Animals; Behavior, Animal; Benzazepines; Benzofurans; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Macaca mulatta; Male; Memory Disorders; Memory, Short-Term; Microdialysis; Positron-Emission Tomography; Prefrontal Cortex; Protein Binding; Pyrrolidines; Radioligand Assay; Receptors, Dopamine D1; Salicylamides; Time Factors; Tritium; Wakefulness | 2005 |
Nicotine normalizes increased prefrontal cortical dopamine D1 receptor binding and decreased working memory performance produced by repeated pretreatment with MK-801: a PET study in conscious monkeys.
Topics: Animals; Benzazepines; Benzofurans; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Macaca mulatta; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Microdialysis; Nicotine; Nicotinic Agonists; Positron-Emission Tomography; Prefrontal Cortex; Pyrrolidines; Receptors, Dopamine D1; Salicylamides | 2005 |
Altered prefrontal dopaminergic function in chronic recreational ketamine users.
Topics: Adult; Analgesics; Benzazepines; Benzofurans; Carbon Radioisotopes; Dopamine; Female; Functional Laterality; Hair; Humans; Illicit Drugs; Ketamine; Male; Memory; Positron-Emission Tomography; Prefrontal Cortex; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Substance Abuse Detection; Substance-Related Disorders; Tissue Distribution; Up-Regulation | 2005 |
Clozapine binds preferentially to cortical D1-like dopamine receptors in the primate brain: a PET study.
Topics: Animals; Basal Ganglia; Benzazepines; Benzofurans; Cerebellum; Cerebral Cortex; Clozapine; Dopamine Agents; Macaca fascicularis; Models, Animal; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D1 | 2006 |
[11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjects.
Topics: Adult; Benzazepines; Benzofurans; Brain; Female; Health; Humans; Male; Positron-Emission Tomography; Receptors, Dopamine D1; Receptors, Serotonin; Risperidone | 2007 |
COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET.
Topics: Adult; Amino Acid Substitution; Benzazepines; Benzofurans; Brain Mapping; Catechol O-Methyltransferase; Cerebral Cortex; Corpus Striatum; Female; Genotype; Humans; Limbic System; Male; Medical History Taking; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Receptors, Dopamine D1 | 2008 |
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA.
Topics: Attention; Benzazepines; Benzofurans; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Color Perception; Corpus Striatum; Dihydroxyphenylalanine; Discrimination Learning; Dopamine; Fluorine Radioisotopes; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Mental Status Schedule; Nerve Net; Neuropsychological Tests; Parkinson Disease; Pattern Recognition, Visual; Positron-Emission Tomography; Presynaptic Terminals; Problem Solving; Psychomotor Performance; Receptors, Dopamine D1; Synaptic Membranes | 2008 |
Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112.
Topics: Adolescent; Adult; Basal Ganglia; Benzazepines; Benzofurans; Carbon Radioisotopes; Depressive Disorder, Major; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1; Sex Characteristics; Young Adult | 2009 |
Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine.
Topics: Adult; Benzazepines; Benzofurans; Brain Mapping; Choice Behavior; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1; Reinforcement Schedule; Self Administration | 2009 |
Imaging cortical dopamine D1 receptors using [11C]NNC112 and ketanserin blockade of the 5-HT 2A receptors.
Topics: Adult; Animals; Benzazepines; Benzofurans; Brain; Carbon Radioisotopes; Humans; Image Interpretation, Computer-Assisted; Ketanserin; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Receptors, Dopamine D1; Serotonin 5-HT2 Receptor Antagonists; Staining and Labeling; Young Adult | 2010 |
Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzazepines; Benzofurans; Brain; Cerebral Cortex; Cognition; Corpus Striatum; Female; Humans; Ligands; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1; Schizophrenia | 2010 |
Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112.
Topics: Adult; Antipsychotic Agents; Benzazepines; Benzofurans; Dopamine; Female; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Prefrontal Cortex; Radiopharmaceuticals; Receptors, Dopamine D1; Schizophrenia; Up-Regulation | 2012 |
In vivo binding of the dopamine-1 receptor PET tracers [¹¹C]NNC112 and [¹¹C]SCH23390: a comparison study in individuals with schizophrenia.
Topics: Adolescent; Adult; Benzazepines; Benzofurans; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Male; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals; Receptors, Dopamine D1; Schizophrenia; Young Adult | 2013 |
The dopamine D₁ receptor agonist (S)-[¹¹C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration--a positron emission tomography examination in the monkey brain.
Topics: Animals; Benzazepines; Benzofurans; Brain; CHO Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Agonists; Humans; Macaca fascicularis; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Receptors, Dopamine D1 | 2013 |
Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia.
Topics: Adult; Aged; Benzazepines; Benzofurans; Corpus Striatum; Dystonic Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1 | 2013 |
Therapeutic doses of buspirone block D3 receptors in the living primate brain.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzazepines; Benzofurans; Buspirone; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Functional Neuroimaging; Globus Pallidus; Injections, Intramuscular; Mesencephalon; Oxazines; Papio anubis; Positron-Emission Tomography; Raclopride; Radioligand Assay; Receptors, Dopamine D3 | 2014 |
First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring.
Topics: Animals; Benzazepines; Benzofurans; Disease Models, Animal; Dopamine; Dopamine Antagonists; Kidney; Papio anubis; Positron-Emission Tomography; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Renin-Angiotensin System | 2014 |
Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects.
Topics: Adult; Benzamides; Benzazepines; Benzofurans; Choice Behavior; Corpus Striatum; Female; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Inhibition, Psychological; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Receptors, Dopamine D1; Receptors, Dopamine D2; Regression Analysis; Young Adult | 2015 |