Page last updated: 2024-09-03

nnc 112 and benzofurans

nnc 112 has been researched along with benzofurans in 30 studies

Compound Research Comparison

Studies (nnc 112)	Trials (nnc 112)	Recent Studies (post-2010) (nnc 112)	Studies (benzofurans)	Trials (benzofurans)	Recent Studies (post-2010) (benzofurans)
32	3	7	13,293	451	4,970

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (20.00)	18.2507
2000's	15 (50.00)	29.6817
2010's	9 (30.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Wachtel, SR; White, FJ	1
Andersen, PH; Nielsen, EB	1
Andersen, PH; Braestrup, C; Grønvald, FC; Guddal, E; Hansen, LB; Hohlweg, R; Nielsen, EB	1
Chou, YH; Farde, L; Foged, C; Halldin, C; Karlsson, P; Sandell, J; Sedvall, G; Swahn, CG	1
Chou, YH; Farde, L; Halldin, C; Karlsson, P; Olsson, H	1
Gerlach, J; Jensen, G; Nicholson, K; Peacock, L	1
Abi-Dargham, A; Anjilvel, S; Foged, C; Guo, NN; Halldin, C; Hwang, DR; Laruelle, M; Lombardo, I; Mann, JJ; Martinez, D; Mawlawi, O; Pidcock, J; Simpson, N; Slifstein, M; Van Heertum, R	1
Laruelle, M; Slifstein, M	1
Abi-Dargham, A; Gil, R; Gorman, JM; Huang, Y; Hwang, DR; Keilp, J; Kochan, L; Laruelle, M; Lombardo, I; Martinez, D; Mawlawi, O; Van Heertum, R	1
Abi-Dargham, A; Guo, N; Huang, YY; Hwang, DR; Laruelle, M; Lo, ES	1
Cumming, P; Doudet, DJ; Rosa-Neto, P	1
Domino, EF; Fukumoto, D; Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H	1
Domino, EF; Fukumoto, D; Kakiuchi, T; Miyasato, K; Nishiyama, S; Tsukada, H	1
Abi-Dargham, A; Cooper, TB; Frankle, WG; Gil, R; Huang, Y; Hwang, DR; Keefe, R; Kegeles, LS; Khenissi, L; Laruelle, M; Martinez, D; Narendran, R; Slifstein, M; Talbot, PS	1
Cropley, VL; Fujita, M; Ghose, S; Hong, J; Innis, RB; Musachio, JL; Nathan, PJ; Pike, VW; Sangare, J	1
Chou, YH; Farde, L; Halldin, C	1
Abi-Dargham, A; Frankle, WG; Gonzales, R; Kegeles, LS; Laruelle, M; Slifstein, M; Xu, X	1
Abi-Dargham, A; Cheng, B; Duvall, M; Frankle, WG; Kolachana, B; Laruelle, M; Simpson, EH; Slifstein, M; Tabares, P; Weinberger, DR	1
Bara-Jimenez, W; Brown, AK; Cropley, VL; Fujita, M; Hallett, M; Herscovitch, P; Innis, RB; Nathan, PJ; Pike, VW; Sangare, J; Zhang, XY	1
Cannon, DM; Drevets, WC; Erickson, K; Klaver, JM; Peck, SA; Rallis-Voak, D	1
Abi-Dargham, A; Broft, A; Fischman, MW; Foltin, RW; Hwang, DR; Kleber, HD; Laruelle, M; Martinez, D; Narendran, R; Perez, A; Slifstein, M	1
Bullich, S; Catafau, AM; Farre, M; Gunn, RN; Herance, R; Laruelle, M; Rabiner, EA; Radua, J; Searle, GE	1
Fujimura, Y; Ito, H; Kishimoto, T; Kosaka, J; Matsumoto, R; Nozaki, S; Okubo, Y; Suhara, T; Takahashi, H; Takano, A; Yasuno, F	1
Abi-Dargham, A; Gil, R; Hwang, DR; Kegeles, LS; Laruelle, M; Narendran, R; Slifstein, M; Thompson, JL; Urban, N; Xu, X	1
Abi-Dargham, A; Girgis, RR; Poels, EM; Slifstein, M; Thompson, JL	1
Bang-Andersen, B; Christoffersen, CT; Farde, L; Finnema, SJ; Gulyás, B; Halldin, C; Jørgensen, M; Wikström, HV	1
Flores, HP; Karimi, M; Moerlein, SM; Perlmutter, JS; Su, Y; Videen, TO	1
Alexoff, D; Carter, P; Fowler, JS; Kang, Y; Kim, D; Kim, SW; King, P; Logan, J; Muench, L; Shea, C; Skolnick, P; Volkow, ND	1
Aisaborhale, E; Borra, RH; Granda, ML; Guimaraes, AR; Hooker, JM; Schauer, N; Schroeder, FA	1
Bilder, R; Borg, J; Brown, AK; Cannon, T; Ghahremani, DG; Ishibashi, K; London, ED; Mandelkern, MA; Robertson, CL; Sabb, F	1

Trials

3 trial(s) available for nnc 112 and benzofurans

Article	Year
Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:2 Topics: Adult; Artifacts; Benzazepines; Benzofurans; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Dopamine Antagonists; Female; Humans; Kinetics; Male; Middle Aged; Neocortex; Radioligand Assay; Receptors, Dopamine D1; Reproducibility of Results; Tomography, Emission-Computed	2000
Prefrontal dopamine D1 receptors and working memory in schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-01, Volume: 22, Issue:9 Topics: Adult; Age Factors; Benzazepines; Benzofurans; Binding, Competitive; Carbon Radioisotopes; Dopamine Antagonists; Female; Humans; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Predictive Value of Tests; Prefrontal Cortex; Principal Component Analysis; Receptors, Dopamine D1; Schizophrenia; Tomography, Emission-Computed	2002
Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2006, Volume: 47, Issue:1 Topics: Adult; Benzazepines; Benzofurans; Female; Humans; Male; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Radiation Dosage; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D1; Tissue Distribution; Whole Body Imaging; Whole-Body Counting	2006

Other Studies

27 other study(ies) available for nnc 112 and benzofurans

Article	Year
The effect of continuous and repeated administration of D1 dopamine receptor antagonist on midbrain dopamine neurons. Neurochemistry international, 1992, Volume: 20 Suppl Topics: Animals; Benzazepines; Benzofurans; Dopamine; Dopamine Antagonists; Male; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	1992
Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists. European journal of pharmacology, 1992, Aug-14, Volume: 219, Issue:1 Topics: Amphetamine; Animals; Behavior, Animal; Benzazepines; Benzofurans; Catalepsy; Dopamine; Male; Mice; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior	1992
NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists. European journal of pharmacology, 1992, Aug-14, Volume: 219, Issue:1 Topics: Animals; Benzazepines; Benzofurans; Dopamine; Dopamine D2 Receptor Antagonists; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Serotonin	1992
Carbon-11-NNC 112: a radioligand for PET examination of striatal and neocortical D1-dopamine receptors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:12 Topics: Adult; Animals; Benzazepines; Benzofurans; Binding, Competitive; Carbon Radioisotopes; Corpus Striatum; Dopamine Antagonists; Humans; Kinetics; Macaca fascicularis; Male; Neocortex; Radioligand Assay; Receptors, Dopamine D1; Sensitivity and Specificity; Stereoisomerism; Tomography, Emission-Computed	1998
A PET study of D(1)-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain. Psychopharmacology, 1999, Volume: 146, Issue:2 Topics: Algorithms; Amphetamine; Animals; Benzazepines; Benzofurans; Brain; Brain Chemistry; Cerebellum; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Ligands; Macaca fascicularis; Neocortex; Neostriatum; Receptors, Dopamine D1; Reserpine; Tomography, Emission-Computed	1999
Extrapyramidal side effects during chronic combined dopamine D1 and D2 antagonist treatment in Cebus apella monkeys. European archives of psychiatry and clinical neuroscience, 1999, Volume: 249, Issue:5 Topics: Animals; Basal Ganglia Diseases; Benzazepines; Benzofurans; Cebus; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Male; Raclopride; Receptors, Dopamine D1; Time Factors	1999
Effects of statistical noise on graphic analysis of PET neuroreceptor studies. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000, Volume: 41, Issue:12 Topics: Animals; Artifacts; Benzazepines; Benzofurans; Brain; Dopamine Antagonists; Humans; Models, Theoretical; Papio; Piperazines; Pyridines; Receptors, Dopamine D1; Receptors, Serotonin; Serotonin Antagonists; Statistics as Topic; Tomography, Emission-Computed	2000
Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:9 Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Benzazepines; Benzofurans; Binding Sites; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; Hippocampus; Male; Prefrontal Cortex; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Schizophrenia; Time Factors; Tritium	2003
Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET. NeuroImage, 2004, Volume: 22, Issue:3 Topics: Animals; Benzazepines; Benzofurans; Binding Sites; Brain Mapping; Carbon Isotopes; Corpus Striatum; Dopamine Antagonists; Macaca mulatta; Male; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Swine; Swine, Miniature; Tissue Distribution; Tomography, Emission-Computed	2004
Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:10 Topics: Animals; Behavior, Animal; Benzazepines; Benzofurans; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Macaca mulatta; Male; Memory Disorders; Memory, Short-Term; Microdialysis; Positron-Emission Tomography; Prefrontal Cortex; Protein Binding; Pyrrolidines; Radioligand Assay; Receptors, Dopamine D1; Salicylamides; Time Factors; Tritium; Wakefulness	2005
Nicotine normalizes increased prefrontal cortical dopamine D1 receptor binding and decreased working memory performance produced by repeated pretreatment with MK-801: a PET study in conscious monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:12 Topics: Animals; Benzazepines; Benzofurans; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Macaca mulatta; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Microdialysis; Nicotine; Nicotinic Agonists; Positron-Emission Tomography; Prefrontal Cortex; Pyrrolidines; Receptors, Dopamine D1; Salicylamides	2005
Altered prefrontal dopaminergic function in chronic recreational ketamine users. The American journal of psychiatry, 2005, Volume: 162, Issue:12 Topics: Adult; Analgesics; Benzazepines; Benzofurans; Carbon Radioisotopes; Dopamine; Female; Functional Laterality; Hair; Humans; Illicit Drugs; Ketamine; Male; Memory; Positron-Emission Tomography; Prefrontal Cortex; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Substance Abuse Detection; Substance-Related Disorders; Tissue Distribution; Up-Regulation	2005
Clozapine binds preferentially to cortical D1-like dopamine receptors in the primate brain: a PET study. Psychopharmacology, 2006, Volume: 185, Issue:1 Topics: Animals; Basal Ganglia; Benzazepines; Benzofurans; Cerebellum; Cerebral Cortex; Clozapine; Dopamine Agents; Macaca fascicularis; Models, Animal; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D1	2006
[11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjects. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:10 Topics: Adult; Benzazepines; Benzofurans; Brain; Female; Health; Humans; Male; Positron-Emission Tomography; Receptors, Dopamine D1; Receptors, Serotonin; Risperidone	2007
COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET. Molecular psychiatry, 2008, Volume: 13, Issue:8 Topics: Adult; Amino Acid Substitution; Benzazepines; Benzofurans; Brain Mapping; Catechol O-Methyltransferase; Cerebral Cortex; Corpus Striatum; Female; Genotype; Humans; Limbic System; Male; Medical History Taking; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Receptors, Dopamine D1	2008
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA. Psychiatry research, 2008, Jul-15, Volume: 163, Issue:2 Topics: Attention; Benzazepines; Benzofurans; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Color Perception; Corpus Striatum; Dihydroxyphenylalanine; Discrimination Learning; Dopamine; Fluorine Radioisotopes; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Mental Status Schedule; Nerve Net; Neuropsychological Tests; Parkinson Disease; Pattern Recognition, Visual; Positron-Emission Tomography; Presynaptic Terminals; Problem Solving; Psychomotor Performance; Receptors, Dopamine D1; Synaptic Membranes	2008
Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:5 Topics: Adolescent; Adult; Basal Ganglia; Benzazepines; Benzofurans; Carbon Radioisotopes; Depressive Disorder, Major; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1; Sex Characteristics; Young Adult	2009
Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:7 Topics: Adult; Benzazepines; Benzofurans; Brain Mapping; Choice Behavior; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1; Reinforcement Schedule; Self Administration	2009
Imaging cortical dopamine D1 receptors using [11C]NNC112 and ketanserin blockade of the 5-HT 2A receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:5 Topics: Adult; Animals; Benzazepines; Benzofurans; Brain; Carbon Radioisotopes; Humans; Image Interpretation, Computer-Assisted; Ketanserin; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Receptors, Dopamine D1; Serotonin 5-HT2 Receptor Antagonists; Staining and Labeling; Young Adult	2010
Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia. Life sciences, 2010, May-22, Volume: 86, Issue:21-22 Topics: Adult; Antipsychotic Agents; Benzazepines; Benzofurans; Brain; Cerebral Cortex; Cognition; Corpus Striatum; Female; Humans; Ligands; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1; Schizophrenia	2010
Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112. Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:6 Topics: Adult; Antipsychotic Agents; Benzazepines; Benzofurans; Dopamine; Female; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Prefrontal Cortex; Radiopharmaceuticals; Receptors, Dopamine D1; Schizophrenia; Up-Regulation	2012
In vivo binding of the dopamine-1 receptor PET tracers [¹¹C]NNC112 and [¹¹C]SCH23390: a comparison study in individuals with schizophrenia. Psychopharmacology, 2013, Volume: 228, Issue:1 Topics: Adolescent; Adult; Benzazepines; Benzofurans; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Male; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals; Receptors, Dopamine D1; Schizophrenia; Young Adult	2013
The dopamine D₁ receptor agonist (S)-[¹¹C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration--a positron emission tomography examination in the monkey brain. Synapse (New York, N.Y.), 2013, Volume: 67, Issue:9 Topics: Animals; Benzazepines; Benzofurans; Brain; CHO Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Agonists; Humans; Macaca fascicularis; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Receptors, Dopamine D1	2013
Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia. Movement disorders : official journal of the Movement Disorder Society, 2013, Volume: 28, Issue:14 Topics: Adult; Aged; Benzazepines; Benzofurans; Corpus Striatum; Dystonic Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D1	2013
Therapeutic doses of buspirone block D3 receptors in the living primate brain. The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:8 Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzazepines; Benzofurans; Buspirone; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Functional Neuroimaging; Globus Pallidus; Injections, Intramuscular; Mesencephalon; Oxazines; Papio anubis; Positron-Emission Tomography; Raclopride; Radioligand Assay; Receptors, Dopamine D3	2014
First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring. American journal of physiology. Renal physiology, 2014, Jul-01, Volume: 307, Issue:1 Topics: Animals; Benzazepines; Benzofurans; Disease Models, Animal; Dopamine; Dopamine Antagonists; Kidney; Papio anubis; Positron-Emission Tomography; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Renin-Angiotensin System	2014
Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-15, Volume: 35, Issue:15 Topics: Adult; Benzamides; Benzazepines; Benzofurans; Choice Behavior; Corpus Striatum; Female; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Inhibition, Psychological; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Receptors, Dopamine D1; Receptors, Dopamine D2; Regression Analysis; Young Adult	2015