naloxone and septide
naloxone has been researched along with septide* in 1 studies
Other Studies
1 other study(ies) available for naloxone and septide
| Article | Year |
|---|---|
Spinal nociceptin inhibits septide but not N-methyl-D-aspartate-induced nociceptive behavior in rats.
Nociceptin can induce spinal analgesia in rats. Here, we tested the ability of nociceptin to inhibit the nociceptive behavior (biting, scratching, licking) induced by intrathecal administration of N-methyl-D-aspartate (4 microg) or the tachykinin NK(1) receptor agonist, septide (0.5 microg), in rats. Intrathecal nociceptin (3-30 nmol) did not modify the NMDA-induced behavior. However, coadministration of nociceptin (1-10 nmol) inhibited the septide-induced excitatory response. This inhibition was unaffected by systemic (10 mg/kg) or intrathecal (30 nmol) administration of naloxone, but intrathecal coadministration of the ORL1 (opioid receptor-like type 1) receptor antagonist [Nphe(1)]nociceptin-(1-13)-NH(2) (30-90 nmol) prevented it, suggesting the involvement of ORL1 receptors. Topics: Animals; Behavior, Animal; Injections, Spinal; Male; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord; Substance P | 2002 |