Page last updated: 2024-09-05

ly 353381 and thiophenes

ly 353381 has been researched along with thiophenes in 68 studies

Compound Research Comparison

Studies (ly 353381)	Trials (ly 353381)	Recent Studies (post-2010) (ly 353381)	Studies (thiophenes)	Trials (thiophenes)	Recent Studies (post-2010) (thiophenes)
70	12	15	17,012	1,961	8,038

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (2.94)	18.2507
2000's	50 (73.53)	29.6817
2010's	16 (23.53)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adrian, MD; Bryant, HU; Rowley, E; Sato, M; Turner, CH; Wang, T	1
Rowley, E; Sato, M; Turner, CH; Zeng, GQ	1
Diaugustine, RP; Hewitt, SC; Klotz, DM; Korach, KS	1
Galid, A; Kubista, E; Seifert, M	1
Hurn, PD; Murphy, SJ; Rossberg, MI; Traystman, RJ	1
Booser, D; Buzdar, A; Dhingra, K; Enas, N; Hudis, C; Major, M; Melemed, A; Münster, PN; Ni, L; Norton, L; Seidman, A; Theriault, R	1
Neubauer, BL; Raghow, S; Steiner, MS	1
Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM	1
Bryant, HU; Burris, LL; Glasebrook, AL; Palkowitz, AD; Pearce, HL; Peer, C; Sporn, MB; Starling, JJ; Suh, N; Wang, Y; Williams, C	1
Bentrem, D; Dardes, RC; Jordan, VC; O'Regan, RM; Schafer, JM	1
Fabian, CJ; Kimler, BF	1
Elit, L; Hirte, H	1
Gajdos, C; Jordan, VC	1
Bethea, CL; Michelson, D; Mirkes, SJ; Su, A	1
Biskobing, DM; Downs, R; Novy, AM	1
Chan, S	2
Cox, DA; Hurn, PD; Littleton-Kearney, MT; Ostrowski, NL; Rossberg, MI	1
Farris, MR; Glasebrook, AL; Grese, TA; Heyman, RA; Lamph, WW; Palkowitz, AD; Risingsong, R; Sporn, MB; Suh, N; Williams, CR	1
Bryant, HU; Jee, WS; Ma, YL; Palkowitz, A; Sato, M; Turner, CH; Zeng, Q	1
Booser, DJ; Buzdar, A; Hudis, C; Jones, SE; Melemed, AS; Munster, PN; O'Shaughnessy, JA; Peterson, P; Pippen, JE; Winer, E	1
Bloss, J; Buller, R; Burke, T; Fowler, J; Gordon, A; McMeekin, DS; Melemed, A; Sabbatini, P	1
Burke, TW; Walker, CL	1
Baselga, J; Bellet, M; Carrasco, E; Enas, N; Guillem-Porta, V; Kayitalire, L; Kerbrat, P; Krejcy, K; Kuta, M; Llombart-Cussac, A; Lluch, A; Namer, M; Petruzelka, L; Vodvarka, P	1
DeGregorio, MW; Marchisano-Karpman, C	1
Fried, A; Segev, E; Wientroub, S; Zeitlin, L	1
Licun, W; Tannock, IF	1
A'Hern, R; Detre, S; Dowsett, M; Johnston, SR; Riddler, S; Salter, J	1
Bartholomaeussen, M; Freddie, CT; Larsen, SS; Lykkesfeldt, AE	1
Berchuck, A; Heyman, RA; Krajewski, S; Lamph, WW; Liby, K; Reed, JC; Rendi, MH; Risingsong, R; Royce, DB; Sporn, MB; Suh, N; Williams, CR	1
Christensen, GL; Freddie, CT; Lykkesfeldt, AE	1
Sporn, MB	1
Albain, KS; Anderson, J; Arneson, DW; Bacus, JW; Beenken, SW; Browne, D; Budd, GT; Burak, WE; Fabian, CJ; Fruehauf, JP; Ganz, PA; Grizzle, WE; Hyams, DM; Johnson, KA; Kimler, BF; Lagios, MD; Mayo, MS; O'Shaughnessy, JA; Sauter, ER; Tawfik, OW	1
Hede, K	1
Bolton, JL; Liu, H; Liu, J; Thatcher, GR; van Breemen, RB	1
David, E; Fournier dit Chabert, J; Lemaire, M; Pellet-Rostaing, S; Perrin, J	1
Johansen, AM	1
Tannock, IF; Wu, L	1
Munster, PN	1
Bolton, JL; Liu, H; Thatcher, GR	1
Brown, P; Kim, H; Krajewski, S; Labrie, F; Lamph, W; Liby, K; Rendi, M; Risingsong, R; Royce, DB; Sporn, MB; Suh, N; Williams, CR; Xu, X	1
Bolton, JL; Chandrasena, RE; Kastrati, I; Liu, H; Petukhov, PA; Qin, Z; Thatcher, GR; Yao, P	1
Bolton, JL; Liu, H; Qin, Z; Thatcher, GR	1
Asghodom, RT; Bolton, JL; Frasor, J; Kastrati, I; Lantvit, DD; Overk, CR; Peng, KW; Qin, Z; Thatcher, GR	1
Bolton, JL; Dietz, BM; Dunlap, T; Kastrati, I; Lantvit, DD; Overk, CR; Qin, Z; Thatcher, GR; Yao, P; Yu, B	1
Buzdar, AU; Deshmane, V; Krishnamurthy, S; Melemed, AS; Peterson, P	1
Ohta, H	1
Bolton, JL; Edirisinghe, P; Qin, Z; Thatcher, GR; Wijewickrama, GT; Yu, B	1
Alam, J; Bolognese, M; Broy, S; Feldman, R; Krege, JH; Lakshmanan, M; Meats, DL; Omizo, M; Utian, WH	1
Jalink, K; Mancini, MA; Michalides, R; Neefjes, J; Rondaij, M; Sharp, ZD; Zwart, W	1
Cox, DA; Downs, RW; Dowsett, SA; Ghosh, A; Harper, K; Moffett, AM	1
Bolton, JL; Lu, M; Peng, KW; Qin, Z; Thatcher, GR; Wang, H; Wang, Z; Wijewickrama, GT	1
Lewiecki, EM	1
Silverman, SL	1
Amewou-Atisso, M; Christiansen, C; Cox, D; Cummings, SR; McClung, M; Miller, P; Mitlak, B; Powles, T; Reginster, JY; Stock, J; Zanchetta, J	1
Dotterer, SK; Forbes, RA; Hammill, CL	1
Powles, T	1
Alam, J; Cox, DA; Dowsett, SA; Kendler, DL; Palacios, S; Stock, J; Zanchetta, J	1
Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H	1
Alam, J; Bhattoa, HP; Cox, DA; Dowsett, SA; Goldstein, SR; Muram, D; Neven, P; Sipos, A	1
Bolton, JL; Chandrasena, ER; Choi, J; Edirisinghe, PD; Hemachandra, LP; Kastrati, I; Thatcher, GR; Wang, YT	1
Chines, AA; Komm, BS	1
Agnusdei, D; Amewou-Atisso, M; Cox, DA; Cummings, SR; Diem, SJ; Dowsett, SA; Fabian, CJ; Muram, D; Neven, P; Powles, TJ; Wickerham, DL	1
Cuzick, J; Sestak, I	1
Calaf Alsina, J; Coronado Martín, PJ	1
Briarava, M; Mocellin, S; Nitti, D; Pilati, P	1
Arantes, HP; Bilezikian, JP; Chiang, AY; Gimeno, SG; Lazaretti-Castro, M	1
de Villiers, TJ	1

Reviews

19 review(s) available for ly 353381 and thiophenes

Article	Year
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. Annals of the New York Academy of Sciences, 2001, Volume: 952 Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Clinical Trials, Phase II as Topic; Cyclooxygenase Inhibitors; Disease Progression; Eflornithine; Endpoint Determination; Enzyme Inhibitors; Estrogens; Female; Fenretinide; Gonadotropin-Releasing Hormone; Humans; Hyperplasia; Isoflavones; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phenotype; Piperidines; Polyamines; Precancerous Conditions; Protein-Tyrosine Kinases; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Uterine Neoplasms	2001
Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer. Current opinion in obstetrics & gynecology, 2002, Volume: 14, Issue:1 Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Neoplasm Staging; Phosphoric Monoester Hydrolases; Piperidines; Progestins; PTEN Phosphohydrolase; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Survival Rate; Thiophenes; Tumor Suppressor Proteins	2002
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade. Clinical breast cancer, 2002, Volume: 2, Issue:4 Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome	2002
Novel therapeutic options for osteoporosis. Current opinion in rheumatology, 2002, Volume: 14, Issue:4 Topics: Animals; Controlled Clinical Trials as Topic; Diphosphonates; Disease Models, Animal; Evidence-Based Medicine; Fractures, Spontaneous; Glycoproteins; Humans; Ibandronic Acid; Imidazoles; Norpregnenes; Osteoporosis; Osteoprotegerin; Piperidines; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Selective Estrogen Receptor Modulators; Thiophenes; Zoledronic Acid	2002
A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer. Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 11 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Endometrial Neoplasms; Estradiol; Female; Fulvestrant; Humans; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2002
Selective estrogen receptor modulators: tissue actions and potential for CNS protection. CNS drug reviews, 2002,Fall, Volume: 8, Issue:3 Topics: Animals; Breast Neoplasms; Cardiovascular System; Central Nervous System; Cognition; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Receptors, Neurotransmitter; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	2002
Arzoxifene as therapy for endometrial cancer. Gynecologic oncology, 2003, Volume: 90, Issue:2 Pt 2 Topics: Antineoplastic Agents, Hormonal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Endometrial Neoplasms; Female; Humans; Multicenter Studies as Topic; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes	2003
Arzoxifene Eli Lilly. IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:9 Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Drugs, Investigational; Humans; Neoplasms; Piperidines; Technology, Pharmaceutical; Thiophenes	2003
Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-15, Volume: 10, Issue:16 Topics: Anticarcinogenic Agents; Breast Neoplasms; Female; Humans; Molecular Structure; Neoplasm Staging; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes	2004
Breast cancer chemoprevention: a review of selective estrogen receptor modulators. Clinical journal of oncology nursing, 2005, Volume: 9, Issue:3 Topics: Breast Neoplasms; Female; Humans; Piperidines; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2005
Arzoxifene: the development and clinical outcome of an ideal SERM. Expert opinion on investigational drugs, 2006, Volume: 15, Issue:3 Topics: Animals; Breast Neoplasms; Endometrial Neoplasms; Female; Humans; Piperidines; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Thiophenes; Treatment Outcome	2006
[Status of novel bone-targeting SERMs in development]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Nov-28, Volume: 65 Suppl 9 Topics: Animals; Bone and Bones; Bone Density; Clinical Trials as Topic; Drug Design; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Research; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes	2007
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis. Journal of women's health (2002), 2009, Volume: 18, Issue:10 Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Parathyroid Hormone; Piperidines; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Vitamin D; Women's Health	2009
New selective estrogen receptor modulators (SERMs) in development. Current osteoporosis reports, 2010, Volume: 8, Issue:3 Topics: Bone Density Conservation Agents; Breast Neoplasms; Female; Humans; Indoles; Osteoporosis; Piperidines; Pyrrolidines; Risk Factors; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes	2010
Preventive therapy for breast cancer: a consensus statement. The Lancet. Oncology, 2011, Volume: 12, Issue:5 Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles	2011
An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis. Maturitas, 2012, Volume: 71, Issue:3 Topics: Bone Density Conservation Agents; Breast; Endometrium; Female; Fractures, Bone; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes	2012
[Third generation selective estrogen receptor modulators: benefits beyond bone. II, endometrial action]. Medicina clinica, 2013, Mar-16, Volume: 140, Issue:6 Topics: Adenocarcinoma; Animals; Breast Neoplasms; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Hot Flashes; Humans; Indoles; Menopause; Multicenter Studies as Topic; Organ Specificity; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Thromboembolism	2013
Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials. Journal of the National Cancer Institute, 2016, Volume: 108, Issue:2 Topics: Adult; Aged; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Norpregnenes; Piperidines; Postmenopause; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes	2016
The quest for new drugs to prevent osteoporosis-related fractures. Climacteric : the journal of the International Menopause Society, 2017, Volume: 20, Issue:2 Topics: Benzoates; Biphenyl Compounds; Bone Density Conservation Agents; Drug Discovery; Humans; Osteoporosis; Osteoporotic Fractures; Piperidines; Propanolamines; Pyrrolidines; Tetrahydronaphthalenes; Thiophenes	2017

Trials

12 trial(s) available for ly 353381 and thiophenes

Article	Year
Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Apr-01, Volume: 19, Issue:7 Topics: Actuarial Analysis; Adult; Aged; Breast Neoplasms; Dose-Response Relationship, Drug; Endometrium; Estrogen Antagonists; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Piperidines; Thiophenes	2001
Phase II, randomized, double-blind study of two dose levels of arzoxifene in patients with locally advanced or metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Neoplasm; Endometrium; Estrogen Receptor Modulators; Female; Humans; Middle Aged; Patient Selection; Piperidines; Receptors, Estrogen; Survival Analysis; Tamoxifen; Thiophenes; Treatment Outcome	2003
A phase II trial of arzoxifene, a selective estrogen response modulator, in patients with recurrent or advanced endometrial cancer. Gynecologic oncology, 2003, Volume: 90, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Endometrial Neoplasms; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes	2003
Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:9 Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Endometrium; Female; Humans; Middle Aged; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes	2003
Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-15, Volume: 10, Issue:16 Topics: Anticarcinogenic Agents; Biopsy; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Hormones; Humans; Middle Aged; Patient Selection; Piperidines; Postmenopause; Reoperation; Selective Estrogen Receptor Modulators; Thiophenes	2004
Phase III double-blind trial of arzoxifene compared with tamoxifen for locally advanced or metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Nov-01, Volume: 25, Issue:31 Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Piperidines; Postmenopause; Receptors, Steroid; Survival Analysis; Tamoxifen; Thiophenes; Time Factors; Treatment Failure	2007
Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:7 Topics: Aged; Algorithms; Antineoplastic Agents; Bone and Bones; Bone Density; Breast Neoplasms; Carcinoma; Endometrium; Female; Humans; Middle Aged; Organ Size; Piperidines; Placebos; Postmenopause; Thiophenes	2009
Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010, Volume: 21, Issue:7 Topics: Aged; Biomarkers; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Humans; Lipids; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Vasomotor System	2010
Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011, Volume: 26, Issue:2 Topics: Aged; Aged, 80 and over; Bone Resorption; Breast Neoplasms; Diphosphonates; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Postmenopause; Selective Estrogen Receptor Modulators; Thiophenes	2011
Arzoxifene versus raloxifene: effect on bone and safety parameters in postmenopausal women with osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012, Volume: 23, Issue:3 Topics: Absorptiometry, Photon; Aged; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Double-Blind Method; Female; Femur Neck; Hip Joint; Hot Flashes; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Thiophenes; Treatment Outcome	2012
Gynecologic effects of arzoxifene in postmenopausal women with osteoporosis or low bone mass. Menopause (New York, N.Y.), 2012, Volume: 19, Issue:1 Topics: Aged; Aged, 80 and over; Endometrial Neoplasms; Endometrium; Female; Genital Diseases, Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Polyps; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Uterine Hemorrhage; Vaginitis; Vulvitis	2012
Breast cancer incidence in postmenopausal women with osteoporosis or low bone mass using arzoxifene. Breast cancer research and treatment, 2012, Volume: 134, Issue:1 Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Double-Blind Method; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Postmenopause; Risk Factors; Thiophenes	2012

Other Studies

37 other study(ies) available for ly 353381 and thiophenes

Article	Year
LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1 Topics: Animals; Biomechanical Phenomena; Body Weight; Bone and Bones; Cholesterol; Estrogen Antagonists; Female; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes; Uterus	1998
LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34). Endocrinology, 1998, Volume: 139, Issue:11 Topics: Animals; Biomechanical Phenomena; Body Weight; Bone Density; Estrogen Antagonists; Female; Humans; Organ Size; Osteoporosis, Postmenopausal; Ovariectomy; Parathyroid Hormone; Piperidines; Rats; Rats, Sprague-Dawley; Thiophenes; Tomography, X-Ray Computed	1998
Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha. Endocrinology, 2000, Volume: 141, Issue:9 Topics: Animals; Benzhydryl Compounds; Blotting, Northern; Estradiol Congeners; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Estrogens, Non-Steroidal; Female; Insulin-Like Growth Factor I; Mice; Mice, Knockout; Mitosis; Ovariectomy; Phenols; Piperidines; Precipitin Tests; Proliferating Cell Nuclear Antigen; Receptors, Estrogen; Ribonucleases; RNA, Messenger; Signal Transduction; Tamoxifen; Thiophenes; Uterus	2000
The oestrogen receptor and its selective modulators in gynaecological oncology. European journal of cancer (Oxford, England : 1990), 2000, Volume: 36 Suppl 4 Topics: Antineoplastic Agents, Hormonal; Cinnamates; Estrogen Antagonists; Female; Genital Neoplasms, Female; Humans; Norpregnenes; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Thiophenes; Toremifene	2000
LY353381.HCl, a selective estrogen receptor modulator, and experimental stroke. Stroke, 2000, Volume: 31, Issue:12 Topics: Animals; Antipyrine; Autoradiography; Brain Ischemia; Carbon Radioisotopes; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Humans; Ovariectomy; Piperidines; Rats; Rats, Wistar; Receptors, Estrogen; Thiophenes	2000
Selective estrogen receptor modulators for the chemoprevention of prostate cancer. Urology, 2001, Volume: 57, Issue:4 Suppl 1 Topics: Age Factors; Androgens; Anticarcinogenic Agents; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogens; Estrogens, Non-Steroidal; Humans; Isoflavones; Male; Phytoestrogens; Piperidines; Plant Preparations; Prostate; Prostatic Neoplasms; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2001
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:8 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2001
Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer research, 2001, Dec-01, Volume: 61, Issue:23 Topics: Animals; Anticarcinogenic Agents; Binding, Competitive; Cell Division; Drug Interactions; Estradiol; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Uterus	2001
Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12 Topics: Animals; Cell Division; Down-Regulation; Endometrial Neoplasms; Estrogen Antagonists; Female; Humans; Mice; Mice, Nude; Piperidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques. Psychoneuroendocrinology, 2002, Volume: 27, Issue:4 Topics: Animals; Carrier Proteins; Estradiol; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Gene Expression; Macaca mulatta; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Piperidines; Raloxifene Hydrochloride; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Estrogen Receptor Modulators; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Tryptophan Hydroxylase	2002
Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:10 Topics: Animals; Anticarcinogenic Agents; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Invasiveness; Nicotinic Acids; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Rats; Selective Estrogen Receptor Modulators; Stromal Cells; Tetrahydronaphthalenes; Thiophenes; Transforming Growth Factor beta	2002
Arzoxifene in breast cancer. European journal of cancer (Oxford, England : 1990), 2002, Volume: 38 Suppl 6 Topics: Breast Neoplasms; Double-Blind Method; Female; Humans; Piperidines; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Thiophenes	2002
Long-term dosing of arzoxifene lowers cholesterol, reduces bone turnover, and preserves bone quality in ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2002, Volume: 17, Issue:12 Topics: Animals; Body Weight; Bone Remodeling; Cholesterol; Female; Ovariectomy; Piperidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes	2002
Effects of long-term administration of N-3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice. Journal of cellular biochemistry, 2003, Oct-01, Volume: 90, Issue:2 Topics: Adipose Tissue; Animals; Body Weight; Bone Marrow Cells; Cholesterol; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Female; Fish Oils; Hypolipidemic Agents; Interleukin-1; Interleukin-10; Interleukin-6; Mice; Mice, Inbred BALB C; Ovariectomy; Ovary; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Skin; Spleen; Thiophenes; Triglycerides; Tumor Necrosis Factor-alpha	2003
Selective estrogen receptor modulators as inhibitors of repopulation of human breast cancer cell lines after chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-01, Volume: 9, Issue:12 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Methotrexate; Neoplasms, Hormone-Dependent; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Tumor Stem Cell Assay	2003
Comparison of the selective estrogen receptor modulator arzoxifene (LY353381) with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast cancer xenograft model. Cancer research, 2003, Oct-01, Volume: 63, Issue:19 Topics: Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Mice; Mice, Nude; Piperidines; Protein Biosynthesis; Proteins; Receptors, Estrogen; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2003
The effect of the new SERM arzoxifene on growth and gene expression in MCF-7 breast cancer cells. Molecular and cellular endocrinology, 2004, Apr-30, Volume: 219, Issue:1-2 Topics: Antineoplastic Agents; Breast Neoplasms; Cathepsin D; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Piperidines; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2004
The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. Cancer research, 2004, May-15, Volume: 64, Issue:10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Synergism; Mammary Neoplasms, Experimental; NF-kappa B; Nicotinic Acids; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes; Transfection; Transforming Growth Factor beta	2004
A new MCF-7 breast cancer cell line resistant to the arzoxifene metabolite desmethylarzoxifene. Molecular and cellular endocrinology, 2004, May-31, Volume: 220, Issue:1-2 Topics: Breast Neoplasms; Cathepsin D; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Piperidines; Proto-Oncogene Proteins c-bcl-2; Receptors, Progesterone; Repressor Proteins; RNA, Messenger; Tamoxifen; Thiophenes; Transcription Factors	2004
Rexinoids may be ready for prime time in prevention, but challenges remain. Journal of the National Cancer Institute, 2004, Dec-15, Volume: 96, Issue:24 Topics: Animals; Anticarcinogenic Agents; Bexarotene; Breast Neoplasms; Clinical Trials as Topic; Disease Models, Animal; Female; Humans; Nicotinic Acids; Piperidines; Retinoid X Receptors; Tetrahydronaphthalenes; Thiophenes	2004
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical research in toxicology, 2005, Volume: 18, Issue:2 Topics: Alkaline Phosphatase; Animals; Biotransformation; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Estradiol; Female; Glutathione; Humans; Kinetics; Microsomes, Liver; Molecular Structure; Oligodeoxyribonucleotides; Piperidines; Quinones; Rats; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes	2005
Efficient access to 2-aryl-3-substituted benzo[b]thiophenes. The Journal of organic chemistry, 2005, Apr-29, Volume: 70, Issue:9 Topics: Cyclization; Molecular Structure; Oxidation-Reduction; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes	2005
Effect of the selective estrogen receptor modulator arzoxifene on repopulation of hormone-responsive breast cancer xenografts between courses of chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-15, Volume: 11, Issue:22 Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunohistochemistry; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Piperidines; Receptors, Estrogen; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays	2005
Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator. Chemical research in toxicology, 2006, Volume: 19, Issue:6 Topics: Animals; Cell Proliferation; Cells, Cultured; DNA Damage; Estrogen Receptor Modulators; Estrogens; Genes, Reporter; Humans; Intestine, Small; Microsomes; Molecular Structure; Oxidation-Reduction; Piperidines; Rats; Thiophenes	2006
The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Oct-01, Volume: 12, Issue:19 Topics: Animals; Cell Division; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Nicotinic Acids; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Survival Rate; Tetrahydronaphthalenes; Thiophenes	2006
Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of medicinal chemistry, 2007, May-31, Volume: 50, Issue:11 Topics: Antioxidants; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Models, Molecular; Oxidation-Reduction; Piperidines; Radioligand Assay; Recombinant Proteins; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes	2007
Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene. Chemical research in toxicology, 2007, Volume: 20, Issue:11 Topics: Alkylation; Animals; Catalysis; Female; Glutathione; Horseradish Peroxidase; Indolequinones; Microsomes; Piperidines; Quinones; Raloxifene Hydrochloride; Rats; Selective Estrogen Receptor Modulators; Thiophenes; Uterus	2007
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. ChemMedChem, 2007, Volume: 2, Issue:10 Topics: Animals; Female; Lipids; Organ Size; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes; Uterus	2007
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular cancer therapeutics, 2007, Volume: 6, Issue:9 Topics: Animals; Antioxidants; Breast Neoplasms; Carcinoma, Hepatocellular; Chemoprevention; Female; Humans; Liver; Liver Neoplasms; Luciferases; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Peroxides; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Cells, Cultured	2007
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjugate chemistry, 2009, Volume: 20, Issue:4 Topics: Animals; Azides; Biotinylation; Cell Extracts; Cell Line, Tumor; Hepatocytes; Indicators and Reagents; Ligands; Mass Spectrometry; Oxidation-Reduction; Piperidines; Proteins; Quinones; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Staining and Labeling; Thiophenes; Xenobiotics	2009
Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1. Molecular endocrinology (Baltimore, Md.), 2009, Volume: 23, Issue:9 Topics: Cell Line, Tumor; Cell Proliferation; Cyclin D1; Drug Resistance; Estrogen Receptor alpha; Estrogen Receptor Modulators; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; HeLa Cells; Humans; Microscopy, Confocal; Models, Chemical; Piperidines; Thiophenes	2009
Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. ACS chemical biology, 2009, Dec-18, Volume: 4, Issue:12 Topics: Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Catechols; Cell Line, Tumor; DNA Damage; Female; Gene Deletion; Humans; Hydroquinones; Piperidines; Prodrugs; Protein Binding; Reactive Oxygen Species; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes	2009
Impact of metal-induced degradation on the determination of pharmaceutical compound purity and a strategy for mitigation. Journal of pharmaceutical and biomedical analysis, 2011, Apr-05, Volume: 54, Issue:5 Topics: Chromatography, High Pressure Liquid; Copper; Drug Contamination; Drug Stability; Indoles; Iron; Molecular Structure; Pharmaceutical Preparations; Piperidines; Solutions; Solvents; Spectrophotometry, Atomic; Thiophenes	2011
Prevention of breast cancer by newer SERMs in the future. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2011, Volume: 188 Topics: Breast Neoplasms; Female; Humans; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes	2011
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. PloS one, 2011, Volume: 6, Issue:11 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Breast; Catechols; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA Adducts; Enzyme Induction; Epithelial Cells; Estrogens; Female; Histone Deacetylase Inhibitors; Horses; Humans; Oxidation-Reduction; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes	2011
Preventive therapy for breast cancer. Current oncology reports, 2012, Volume: 14, Issue:6 Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Meta-Analysis as Topic; Middle Aged; Piperidines; Preventive Medicine; Pyrrolidines; Raloxifene Hydrochloride; Receptor, ErbB-2; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes	2012
Incidence of vertebral fractures in calcium and vitamin D-supplemented postmenopausal Brazilian women with osteopenia or osteoporosis: data from Arzoxifene Generations Trial. Archives of endocrinology and metabolism, 2016, Volume: 60, Issue:1 Topics: Age Distribution; Aged; Aged, 80 and over; Bone Diseases, Metabolic; Brazil; Calcium; Dietary Supplements; Female; Follow-Up Studies; Humans; Incidence; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Postmenopause; Randomized Controlled Trials as Topic; Risk Factors; Spinal Fractures; Thiophenes; Vitamin D	2016