ly 117018 has been researched along with tamoxifen in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (54.72) | 18.7374 |
| 1990's | 15 (28.30) | 18.2507 |
| 2000's | 9 (16.98) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blaszczak, LC; Crowell, TA; Goettel, ME; Jones, CD; Mabry, TE; Ruenitz, PC; Srivatsan, V; Suarez, T | 1 |
| Kon, OL; Ng, SC; Sim, KY; Teo, CC | 1 |
| Durani, S; Kapil, RS; Saeed, A; Sharma, AP | 2 |
| Black, LJ; Clemens, JA; Falcone, JF; Jevnikar, MG; Jones, CD; Peters, MK; Pike, AJ; Thompson, AR | 1 |
| Ballejo, G; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Koga, M; Sutherland, RL | 2 |
| Hagino, Y; Kohno, K; Kuwano, M; Mizoguchi, H; Uchiumi, T | 1 |
| Braunsberg, H; Coldham, NG; Patel, K | 1 |
| Durani, N; Durani, S; Jain, R; Kapil, RS; Saeed, A; Sharma, AP | 1 |
| Arnold, AP; Mathews, GA | 1 |
| Boundy, V; Komm, BS; Lyttle, CR; Sundstrom, SA; Xu, Q | 1 |
| Galman, MS; Lyttle, CR; Sundstrom, SA | 1 |
| Davidson, NE; Gelmann, EP; Kasid, A; Lippman, ME | 1 |
| Hölzel, F; May, FE; Westley, BR | 1 |
| Dickson, RB; Katz, D; Lippman, ME; Shima, TB; Thompson, EW; Wakeling, AE | 1 |
| Johnson, MD; Kastner, P; May, FE; Wakeling, AE; Westley, BR; Wiseman, LR | 1 |
| Katzenellenbogen, BS; Toney, TW | 1 |
| Giambiagi, N; Pasqualini, JR; Sumida, C | 1 |
| Crastes de Paulet, A; Cypriani, B; Descomps, B; Tabacik, C | 1 |
| Dey, SK; Huet, YM | 1 |
| Shimizu, S; Takeda, A | 1 |
| Bronzert, DA; Davidson, N; Lippman, M | 1 |
| Amara, JF; Dannies, PS | 1 |
| Amara, JF; Dannies, PS; Martinez-Campos, A | 1 |
| Donahoe, PK; Hutson, JM; MacLaughlin, DT | 1 |
| Campen, CA; Gorski, J; Jordan, VC | 1 |
| Bronzert, DA; Greene, GL; Lippman, ME | 1 |
| Jordan, VC | 1 |
| Green, LR; Newboult, E; Valcaccia, B; Wakeling, AE | 1 |
| Newboult, E; O'Connor, KM; Wakeling, AE | 1 |
| Valcaccia, B; Wakeling, AE | 1 |
| Gosden, B; Jordan, VC | 2 |
| Jordan, VC; Mueller, GC; Olsen, MR; Tate, AC; Van Oosbree, TR | 1 |
| Huff, KK; Lippman, ME; Scholl, SM | 1 |
| Keeping, HS; Lyttle, CR | 1 |
| Black, LJ; Goode, RL; Jones, CD | 1 |
| Black, LJ; Goode, RL | 2 |
| Borras, M; Bouhoute, A; Jin, L; Leclercq, G; Legros, N | 1 |
| Berthois, Y; Crastes de Paulet, A; Dussert, C; Martin, PM; Pons, M | 1 |
| De Caterina, R; Genazzani, AR; Simoncini, T | 1 |
| Acharya, A; Lei, J; Neugarten, J; Silbiger, S | 1 |
| Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM | 1 |
| Balaguer, P; Bonnet, S; Cavaillès, V; Duong, V; Escande, A; Margueron, R; Vignon, F | 1 |
| Barone, G; Bollati, A; Bonfanti, C; Burattin, A; Cozzi, R; Giustina, A; Poiesi, C; Tulipano, G; Turazzi, S; Valle, D | 1 |
| Levine, L | 1 |
| Body, JJ; Journé, F; Laurent, G; Leclercq, G; Nonclercq, D | 1 |
| Chin, WW; Dantzig, AH; Iversen, PW; Jin, S; Krishnan, V; Lesoon, A; Moore, RE; O'Brien, KA; Peek, VL; Perry, WL; Rolfe, M; Sampath, J; Shepard, RL; Shyjan, A; Tighe, M; Williamson, M; Yaden, B | 1 |
| Benjamins, JA; Deighton-Collins, S; Guzmán, CB; Kleerekoper, M; Martinez, A; Skafar, DF; Zhao, C | 1 |
| Clarke, R; Dai, P; Lou, MA; Lu, JF; Nazarov, V; Wong, LJ | 1 |
3 review(s) available for ly 117018 and tamoxifen
| Article | Year |
|---|---|
Pharmacodynamic and biological effects of anti-estrogens in different models.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Clomiphene; DNA-Binding Proteins; Estradiol; Estrogen Antagonists; Female; Growth Substances; Humans; Lipoproteins, LDL; Liver; Nafoxidine; Nitromifene; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Species Specificity; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1988 |
Estrogen and antiestrogen resistance in human breast cancer cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line; Diethylstilbestrol; Drug Resistance; Estradiol; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Humans; Molecular Weight; Pyrrolidines; Tamoxifen; Thiophenes; Time Factors | 1986 |
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes | 1983 |
50 other study(ies) available for ly 117018 and tamoxifen
| Article | Year |
|---|---|
Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone.
Topics: Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Calmodulin; Cell Division; Estradiol; Estrogen Antagonists; Humans; Molecular Structure; Phenols; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured | 1992 |
Synthesis of 2-(p-chlorobenzyl)-3-aryl-6-methoxybenzofurans as selective ligands for antiestrogen-binding sites. Effects on cell proliferation and cholesterol synthesis.
Topics: Benzofurans; Binding Sites; Binding, Competitive; Cell Division; Cell Line; Cholesterol; Estrogen Antagonists; Humans; Ligands; Receptors, Estrogen; Thymidine | 1992 |
Structure-activity relationship of antiestrogens. Phenolic analogues of 2,3-diaryl-2H-1-benzopyrans.
Topics: Animals; Benzopyrans; Binding, Competitive; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Mice; Molecular Structure; Organ Size; Phenols; Piperidines; Rats; Receptors, Estrogen; Structure-Activity Relationship; Uterus | 1990 |
Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone hydrochloride (LY156758), a remarkably effec
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Estrogen Antagonists; Female; Mammary Neoplasms, Experimental; Piperidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Structure-Activity Relationship; Uterus | 1984 |
Differential effects of estrogen and antiestrogen on transforming growth factor gene expression in endometrial adenocarcinoma cells.
Topics: Adenocarcinoma; Analysis of Variance; Cell Division; Cell Line; Dose-Response Relationship, Drug; Endometrial Neoplasms; ErbB Receptors; Estradiol; Estrogen Antagonists; Female; Gene Expression; Humans; Kinetics; Polyunsaturated Alkamides; Pyrrolidines; RNA, Messenger; Tamoxifen; Thiophenes; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1992 |
Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation.
Topics: Breast Neoplasms; Calcitriol; Cell Division; Cell Line; Clomiphene; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Calcitriol; Receptors, Estradiol; Receptors, Steroid; Tamoxifen; Thiophenes; Tretinoin | 1991 |
Counteraction of estradiol-induced activation of tissue-type plasminogen activator in a human breast cancer cell line by an anti-estrogen, LY117018.
Topics: Breast Neoplasms; Cell Division; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogen Antagonists; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Pyrrolidines; Receptors, Estrogen; RNA; Tamoxifen; Thiophenes; Tissue Plasminogen Activator | 1991 |
Hormone and cytotoxic drug responsiveness of cultured human breast cancer cells resistant to specific hormones.
Topics: Breast Neoplasms; Cell Division; Dexamethasone; Drug Resistance; Estradiol; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Methotrexate; Pyrrolidines; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Vincristine | 1990 |
Structure-activity relationship of antiestrogens. Studies on 2,3-diaryl-1-benzopyrans.
Topics: Animals; Benzopyrans; Biological Assay; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Molecular Structure; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1990 |
Structure-activity relationship of antiestrogens. Effect of the side chain and its position on the activity of 2,3-diaryl-2H-1-benzopyrans.
Topics: Animals; Benzopyrans; Binding, Competitive; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Mice; Microsomes, Liver; Molecular Structure; Organ Size; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1990 |
Antiestrogens fail to prevent the masculine ontogeny of the zebra finch song system.
Topics: Animals; Birds; Brain; Estrogen Antagonists; Female; Male; Pyrrolidines; Sex Differentiation; Stilbenes; Tamoxifen; Thiophenes; Vocalization, Animal | 1990 |
The stimulation of uterine complement component C3 gene expression by antiestrogens.
Topics: Animals; Complement C3; Drug Interactions; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Kinetics; Nucleic Acid Hybridization; Piperidines; Progesterone; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus | 1990 |
Antagonism of estrogen- and antiestrogen-induced uterine complement component C3 expression by ICI 164,384.
Topics: Animals; Complement C3; Epithelial Cells; Estradiol; Estrogen Antagonists; Female; Organ Size; Polyunsaturated Alkamides; Pyrrolidines; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus | 1990 |
Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells.
Topics: Amanitins; Breast Neoplasms; Cell Cycle; Cell Line; DNA; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation; Humans; Methylation; Pyrrolidines; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Thymidine; Thymidine Kinase; Time Factors | 1986 |
Effects of oestrogen and the antioestrogens, tamoxifen and LY117018, on four oestrogen-regulated RNAs in the EFM-19 breast cancer cell line.
Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Gene Expression Regulation; Humans; Nucleic Acid Hybridization; Pyrrolidines; Receptors, Estrogen; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1989 |
ICI 164,384, a pure antagonist of estrogen-stimulated MCF-7 cell proliferation and invasiveness.
Topics: Basement Membrane; Binding, Competitive; Breast Neoplasms; Cell Cycle; Estradiol; Estrogen Antagonists; Humans; Neoplasm Invasiveness; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Stimulation, Chemical; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1989 |
Regulation of progesterone receptor mRNA by oestradiol and antioestrogens in breast cancer cell lines.
Topics: Animals; Autoradiography; Blotting, Northern; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogen Antagonists; Mammary Neoplasms, Experimental; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Progesterone; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1989 |
An evaluation of the interactions of antiestrogens with pituitary and striatal dopamine receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Diethylamines; Estrogen Antagonists; Female; Nitromifene; Pituitary Gland, Anterior; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tamoxifen; Thiophenes | 1987 |
Role of estrogen receptors and antiestrogen binding sites in an early effect of antiestrogens, the inhibition of cholesterol biosynthesis.
Topics: Animals; Binding Sites; Cell Division; Cell Line; Cholesterol; Humans; Molecular Weight; Pyrrolidines; Rats; Receptors, Drug; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1988 |
Role of early and late oestrogenic effects on implantation in the mouse.
Topics: Animals; Clomiphene; Embryo Implantation; Embryo Implantation, Delayed; Estradiol; Estriol; Estrogens; Female; Mice; Mice, Inbred Strains; Nafoxidine; Nitromifene; Organ Size; Ovariectomy; Progesterone; Pyrrolidines; Tamoxifen; Thiophenes; Uterus | 1987 |
Molecular effects of antiestrogens (tamoxifen and LY117018) on estrogen-dependent glycoprotein (USP-1) synthesized and secreted by rat uterine epithelial cells.
Topics: Animals; Epithelium; Estradiol; Estrogen Antagonists; Female; Kinetics; Neoplasm Proteins; Ovariectomy; Pyrrolidines; Rats; Rats, Inbred Strains; Reference Values; Tamoxifen; Thiophenes; Uterus | 1988 |
Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth.
Topics: Breast Neoplasms; Cell Division; Cell Line; Clomiphene; Epidermal Growth Factor; Estrogen Antagonists; Humans; Pyrrolidines; Tamoxifen; Thiophenes | 1987 |
Characterization of antiestrogen stimulation of cell number and prolactin production.
Topics: Cell Cycle; Cell Line; Estradiol; Pituitary Gland; Prolactin; Pyrrolidines; Tamoxifen; Thiophenes | 1986 |
Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures.
Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Kinetics; Male; Pituitary Gland, Anterior; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes | 1986 |
Steroid modulation of Mullerian duct regression in the chick embryo.
Topics: Aminoglutethimide; Androstenedione; Animals; Anti-Mullerian Hormone; Chick Embryo; Drug Interactions; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Growth Inhibitors; Male; Mullerian Ducts; Norethindrone; Pyrrolidines; Tamoxifen; Testicular Hormones; Thiophenes | 1985 |
Opposing biological actions of antiestrogens in vitro and in vivo: induction of progesterone receptor in the rat and mouse uterus.
Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Female; In Vitro Techniques; Mice; Mice, Inbred ICR; Pyrrolidines; Rats; Receptors, Progesterone; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1985 |
Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Drug Resistance; Estradiol; Female; Humans; Molecular Weight; Phenotype; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes | 1985 |
Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line; Estrogen Antagonists; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus | 1984 |
Comparison of the biological effects of tamoxifen and a new antioestrogen (LY 117018) on the immature rat uterus.
Topics: Animals; Estradiol; Estrogen Antagonists; Female; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Sexual Maturation; Tamoxifen; Thiophenes; Uterus | 1983 |
Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens.
Topics: Animals; Estradiol; Estrogen Antagonists; Female; Mammary Neoplasms, Experimental; Organ Size; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes; Uterus | 1983 |
Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor.
Topics: Animals; Binding, Competitive; Estrogen Antagonists; Female; Kinetics; Organ Size; Promegestone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Sexual Maturation; Tamoxifen; Thiophenes; Uterus | 1983 |
An immobilized antiestrogen binds a specific uterine protein in addition to estrogen receptor proteins.
Topics: Agar; Animals; Carrier Proteins; Cytosol; Estrogen Antagonists; Female; Molecular Weight; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus | 1984 |
Inhibition of the uterotropic activity of estrogens and antiestrogens by the short acting antiestrogen LY117018.
Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Female; Mice; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1983 |
Antiestrogenic effects of LY 117018 in MCF-7 cells.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes | 1983 |
Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol.
Topics: Animals; Cytosol; Estradiol; Female; Organ Size; Peroxidases; Progesterone; Promegestone; Pyrrolidines; Rats; Receptors, Progesterone; Tamoxifen; Thiophenes; Uterus | 1982 |
Differential interaction of antiestrogens with cytosol estrogen receptors.
Topics: Animals; Binding, Competitive; Cytosol; Estradiol; Estrogen Antagonists; Female; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Temperature; Thiophenes; Uterus | 1981 |
Evidence for biological action of the antiestrogens LY117018 and tamoxifen by different mechanisms.
Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Female; Pyrrolidines; Rats; Receptors, Estradiol; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1981 |
Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice.
Topics: Aging; Animals; Biological Assay; Castration; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Female; Mice; Pyrrolidines; Rats; Species Specificity; Tamoxifen; Thiophenes; Uterus | 1980 |
Evaluation of estrogen receptor, antiestrogen binding sites and calmodulin for antiestrogen resistance of two clones derived from the MCF-7 breast cancer cell line.
Topics: Binding Sites; Calmodulin; Cell Division; Clone Cells; Drug Resistance; Estrogen Antagonists; Humans; Imidazoles; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1994 |
Agonist-antagonist activity of anti-estrogens in the human breast cancer cell line MCF-7: an hypothesis for the interaction with a site distinct from the estrogen binding site.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Estradiol; Estrogen Antagonists; Humans; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1994 |
Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells.
Topics: Cells, Cultured; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Gene Expression; Humans; Lipopolysaccharides; Pyrrolidines; Receptors, Estrogen; RNA, Messenger; Saphenous Vein; Tamoxifen; Thiophenes; Vascular Cell Adhesion Molecule-1 | 1999 |
Selective estrogen receptor modulators suppress mesangial cell collagen synthesis.
Topics: Angiotensin II; Animals; Cell Line, Transformed; Collagen; Endothelin-1; Estrogen Receptor beta; Estrogens; Glomerular Mesangium; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Pyrrolidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta; Up-Regulation | 2000 |
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens.
Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Fulvestrant; Genes, Reporter; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Pyrrolidines; Raloxifene Hydrochloride; Response Elements; Tamoxifen; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: In vitro studies.
Topics: Adenoma; Adult; Aged; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Middle Aged; Pituitary Gland; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Secretory Rate; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2004 |
Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Arachidonic Acid; Breast Neoplasms; Colonic Neoplasms; Cyclooxygenase 2; Epoprostenol; Estrogen Antagonists; Humans; Isoenzymes; Liver; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 2004 |
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.
Topics: Breast Neoplasms; Cycloheximide; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunoenzyme Techniques; Lactones; Leupeptins; Ligands; Macrolides; Molecular Chaperones; Proteasome Inhibitors; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Pyrrolidines; Signal Transduction; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 2004 |
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
Topics: Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estrogen Receptor beta; Etoposide; Female; Humans; Mitoxantrone; Ovarian Neoplasms; Pyrrolidines; RNA Splicing; RNA Splicing Factors; RNA-Binding Proteins; RNA, Catalytic; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection | 2005 |
Activity of estradiol and selective estrogen receptor modulators in the mouse N20.1 oligodendrocyte/astrocytes cell line.
Topics: Animals; Astrocytes; Blotting, Western; Cell Line; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression Regulation; Ligands; Luciferases; Mice; Neuroglia; Oligodendroglia; Plasmids; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection | 2005 |
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.
Topics: Acetyltransferases; Alleles; Breast Neoplasms; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Neoplasm; Estradiol; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Receptor Coactivator 3; Oncogene Proteins; Peptides; Polymerase Chain Reaction; Pyrrolidines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators; Sequence Analysis, DNA; Tamoxifen; Thiophenes; Trans-Activators | 2006 |