lu 135252 and bq 123
lu 135252 has been researched along with bq 123 in 6 studies
Compound Research Comparison
| Studies (lu 135252) | Trials (lu 135252) | Recent Studies (post-2010) (lu 135252) | Studies (bq 123) | Trials (bq 123) | Recent Studies (post-2010) (bq 123) |
|---|---|---|---|---|---|
| 196 | 13 | 14 | 1,391 | 63 | 152 |
Protein Interaction Comparison
| Protein | Taxonomy | lu 135252 (IC50) | bq 123 (IC50) |
|---|---|---|---|
| Endothelin-1 receptor | Homo sapiens (human) | 0.017 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 0.014 |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ | 1 |
| Ehrenreich, H; Hasselblatt, M; Jensen, N; Kamrowski-Kruck, H; Kratzin, H; Schilling, L; Sirén, AL | 1 |
| Lüscher, TF; Noll, G; Ruschitzka, FT; Spieker, LE | 1 |
| Lüscher, TF; Spieker, LE | 1 |
| Austin, PC; Lapointe, N; Lee, DS; Nguyen, QT; Ohlsson, A; Rouleau, JL; Stewart, DJ; Tu, JV | 1 |
| Miyauchi, T | 1 |
Reviews
4 review(s) available for lu 135252 and bq 123
| Article | Year |
|---|---|
Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?
Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Forecasting; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Myocardial Contraction; Peptides, Cyclic; Phenylpropionates; Predictive Value of Tests; Prognosis; Pyrimidines; Sulfonamides; Time Factors; Vascular Resistance; Vasoconstriction; Ventricular Function, Left | 2001 |
Will endothelin receptor antagonists have a role in heart failure?
Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome | 2003 |
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure.
Topics: Animals; Atrasentan; Cardiotonic Agents; Endothelin Receptor Antagonists; Heart Failure; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Risk; Survival Rate | 2003 |
[Endothelin and heart failure].
Topics: Animals; Biomarkers; Clinical Trials as Topic; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression; Heart Failure; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Pathologic; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Transcription Factors; Vasoconstriction; Ventricular Remodeling | 2004 |
Trials
1 trial(s) available for lu 135252 and bq 123
| Article | Year |
|---|---|
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones | 2004 |
Other Studies
1 other study(ies) available for lu 135252 and bq 123
| Article | Year |
|---|---|
ETA and ETB receptor antagonists synergistically increase extracellular endothelin-1 levels in primary rat astrocyte cultures.
Topics: Animals; Animals, Newborn; Astrocytes; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Hirudins; Kinetics; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Thrombin; Transcription, Genetic | 1998 |