lignans has been researched along with xanthone* in 1 studies
1 other study(ies) available for lignans and xanthone
| Article | Year |
|---|---|
Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense.
Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 μg/mL (8.4 μM) and 4 μg/mL (16.8 μM), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 μg/mL (100 μM). Topics: Animals; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Drugs, Chinese Herbal; Hypericum; Lignans; Mice; Microbial Sensitivity Tests; Molecular Structure; Multidrug Resistance-Associated Proteins; Norfloxacin; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Plant Leaves; Staphylococcus aureus; Tetracycline; Xanthones | 2010 |