lignans has been researched along with kakoul* in 2 studies
2 other study(ies) available for lignans and kakoul
Article | Year |
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Constituents of Asarum sieboldii with inhibitory activity on lipopolysaccharide (LPS)-induced NO production in BV-2 microglial cells.
Bioassay-guided fractionation of the root extract of Asarum sieboldii led to the isolation of the four active compounds (-)-sesamin (1), (2E,4E,8Z,10E)-N-(2-methylpropyl)dodeca-2,4,8,10-tetraenamide (2), kakuol (3), and '3,4,5-trimethoxytoluene' (=1,2,3-trimethoxy-5-methylbenzene; 4), in terms of inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Compounds 1-4 showed potent inhibition of NO production, with IC(50) values in the low nanomolar-to-micromolar range. Also isolated were the known compounds methylkakuol (5), '3,5-dimethoxytoluene', safrole, asaricin, methyleugenol, and (-)-asarinin, which were found to be inactive in the above assay. Among the ten known isolates, compounds 1, 2, and 5 were found for the first time in this plant. Topics: Animals; Aristolochiaceae; Cell Line; Dioxoles; Dose-Response Relationship, Drug; Lignans; Lipopolysaccharides; Mice; Microglia; Molecular Structure; Nitric Oxide; Plant Roots; Polyunsaturated Alkamides; Propiophenones; Stereoisomerism; Structure-Activity Relationship; Toluene | 2008 |
[Studies on the chemical constituents from Asarum Chinese Franch. f. fargesii (Franch.) C. Y. Cheng (II)].
Three compounds were isolated from the roots and stems of Asarum chinese Franch. f. fargesii (Franch.) C. Y. Cheng with column chromatography methods. Their structures were identified as kakuol (I), 2-methoxy-4,5-methylenedioxypropiophenone (II) and pluviatilol (III) on the basis of physicochemical and spectroscopic analysis. The compound II and III were isolated from the genus of Asarum for the first time. Topics: Asarum; Lignans; Molecular Structure; Plants, Medicinal; Propiophenones; Rhizome; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2006 |