lignans and carbene

lignans has been researched along with carbene* in 2 studies

Other Studies

2 other study(ies) available for lignans and carbene

Article	Year
Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver. Drug design, development and therapy, 2018, Volume: 12 Schisandrin B (Sch B) a main active component of. The present study determined and identifed the carbene reactive metabolite of Sch B in human and mice liver microsomes. Its roles in activating Nrf2 pathway and modifying macromolecules were further explored in human liver microsomes. Moreover the potential cytotoxicity and hepatoxicity of carbene on HepG-2 and mice were also investigated.. The present study revealed that CYP450s mediate the conversion of Sch B to carbene, which subsequently binds to Keap1 and elicits Nrf2 pathway, which could further increase the elimination of carbene and thus exhibit a less harmful effect on mice liver. Topics: Activation, Metabolic; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Lignans; Liver; Male; Methane; Mice; Microsomes, Liver; NF-E2-Related Factor 2; Polycyclic Compounds; Signal Transduction	2018
Improved stereoselective synthesis of optically active methylene lactone, key intermediate for the synthesis of 1,2-oxidized furofuran lignan, by direct alpha-methylenation to butanolide. Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:10 (3R)-3-[(1R)-1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl) methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L-glutamic acid by applying direct methylenation to butanolide. Topics: 4-Butyrolactone; Dioxoles; Furans; Hydrocarbons; Lignans; Magnetic Resonance Spectroscopy; Methane; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism	2000

Article

Year

Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver.

Drug design, development and therapy, 2018, Volume: 12

Schisandrin B (Sch B) a main active component of. The present study determined and identifed the carbene reactive metabolite of Sch B in human and mice liver microsomes. Its roles in activating Nrf2 pathway and modifying macromolecules were further explored in human liver microsomes. Moreover the potential cytotoxicity and hepatoxicity of carbene on HepG-2 and mice were also investigated.. The present study revealed that CYP450s mediate the conversion of Sch B to carbene, which subsequently binds to Keap1 and elicits Nrf2 pathway, which could further increase the elimination of carbene and thus exhibit a less harmful effect on mice liver.

Topics: Activation, Metabolic; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Lignans; Liver; Male; Methane; Mice; Microsomes, Liver; NF-E2-Related Factor 2; Polycyclic Compounds; Signal Transduction

2018

Improved stereoselective synthesis of optically active methylene lactone, key intermediate for the synthesis of 1,2-oxidized furofuran lignan, by direct alpha-methylenation to butanolide.

Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:10

(3R)-3-[(1R)-1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl) methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L-glutamic acid by applying direct methylenation to butanolide.

Topics: 4-Butyrolactone; Dioxoles; Furans; Hydrocarbons; Lignans; Magnetic Resonance Spectroscopy; Methane; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2000