lignans and cadinane

One unusual metal complex of cadinane sesquiterpene alkaloid (1), one new cadinane sesquiterpene alkaloid (2) and two new neolignan glycosides (3-4) along with six known cadinane sesquiterpene derivatives (5-10), nineteen known phenolic glycosides (11-29) were isolated from the aerial parts of Alangium alpinum. Structures of new crystals of metal complex were characterized by X-Ray diffraction and ICP-AES analysis. Other new compounds were elucidated by combined use and detailed analysis of HR-ESIMS, 1D and 2D NMR and CD spectroscopic method. In addition, all isolated compounds were tested for their inhibitory effects against TNF-α induced NF-κB activation in Hela cells and NO production in RAW 264.7 macrophages.

Topics: Alangiaceae; Alkaloids; Animals; Glycosides; HeLa Cells; Humans; Lignans; Metals; Mice; Molecular Structure; NF-kappa B; Nitric Oxide; Plant Components, Aerial; Polycyclic Sesquiterpenes; RAW 264.7 Cells; Sesquiterpenes; Tumor Necrosis Factor-alpha