lignans and apatinib
lignans has been researched along with apatinib* in 1 studies
Other Studies
1 other study(ies) available for lignans and apatinib
| Article | Year |
|---|---|
The synergistic anti-tumor effect of schisandrin B and apatinib.
The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migration and invasion, by means of wound-healing and transwell invasion assay. Flow cytometry results showed that Sch.B enhanced apoptosis induced by apatinib. The results were confirmed by western blot analysis of the proteins MMP-9, and Bax caspase-9, and -12. These results suggest that combining apatinib and Sch.B is an effective therapeutic strategy for preventing GC progression. [Formula: see text]. Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Lignans; Molecular Structure; Polycyclic Compounds; Pyridines | 2020 |