Page last updated: 2024-08-17

levodopa and prazosin

levodopa has been researched along with prazosin in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19904 (21.05)18.7374
1990's4 (21.05)18.2507
2000's7 (36.84)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Sternon, J1
Lizogub, VG; Piatak, OA; Yanovskii, GV1
Fukuda, H; Ono, H; Tanabe, M1
Ohno, Y; Sasa, M; Takaori, S; Yoshida, O; Yoshimura, N1
Maj, J; Michaluk, J; Rawłów, A; Rogóz, Z; Skuza, G1
Henning, M; Hermansson, LE; Johansson, P1
Cade, JR; Fregly, MJ; Hegland, D; Rossi, F; Sun, Z; Tümer, N; Yürekli, M1
Sickles, AE; Stehouwer, DJ; Taylor, LL; Van Hartesveldt, C1
Mueller, J; Poewe, W; Puschban, Z; Scherfler, C; Seppi, K; Stefanova, N; Wenning, GK1
Archer, T; Fredriksson, A1
Adamidis, K; Harkitis, P; Johnson, EO; Konstandi, M; Kostakis, D; Lang, MA; Marselos, M1
Brotchie, JM; Fox, SH; Johnston, TH; Millan, MJ; Visanji, NP1

Trials

1 trial(s) available for levodopa and prazosin

ArticleYear
The influence of adrenoreactive preparations on clinical and haemodynamic parameters in patients with ischaemic heart disease.
    Cor et vasa, 1991, Volume: 33, Issue:1

    Topics: Adult; Angina Pectoris; Coronary Artery Disease; Coronary Disease; Double-Blind Method; Exercise Test; Hemodynamics; Humans; Levodopa; Middle Aged; Nonachlazine; Oxprenolol; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta

1991

Other Studies

18 other study(ies) available for levodopa and prazosin

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[The practitioner and drug-induced, predominantly orthostatic hypotension].
    Acta clinica Belgica, 1978, Volume: 33, Issue:6

    Topics: Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Antipsychotic Agents; Barbiturates; Butyrophenones; Clonidine; Debrisoquin; Diazoxide; Diuretics; Ganglionic Blockers; Humans; Hydralazine; Hypotension, Orthostatic; Levodopa; Meprobamate; Methyldopa; Mineralocorticoids; Monoamine Oxidase Inhibitors; Phenothiazines; Prazosin; Psychotropic Drugs; Reserpine; Vasodilator Agents

1978
Spinal alpha 1- and alpha 2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.
    Japanese journal of pharmacology, 1990, Volume: 54, Issue:1

    Topics: Animals; Clonidine; Clorgyline; Levodopa; Male; Motor Neurons; Piperoxan; Prazosin; Premedication; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex, Monosynaptic; Spinal Cord; Synaptic Transmission

1990
Contraction of urinary bladder by central norepinephrine originating in the locus coeruleus.
    The Journal of urology, 1988, Volume: 139, Issue:2

    Topics: Animals; Cats; Electric Stimulation; Hypogastric Plexus; Levodopa; Locus Coeruleus; Muscle Contraction; Norepinephrine; Phentolamine; Prazosin; Pressure; Reserpine; Sotalol; Urinary Bladder; Yohimbine

1988
Central action of the antidepressant drug pirlindole.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:8

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Blepharoptosis; Body Temperature; Carbazoles; Cerebral Cortex; Clonidine; Dihydroalprenolol; Levodopa; Male; Mice; Norepinephrine; Prazosin; Rats; Reserpine; Serotonin

1986
Mediation and mechanisms of the hypotensive effect of L-dopa in the sea-gull: Larus argentatus.
    European journal of pharmacology, 1983, Jun-03, Volume: 90, Issue:2-3

    Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Birds; Blood Pressure; Heart Rate; Levodopa; Prazosin; Receptors, Dopamine; Time Factors; Vagotomy; Yohimbine

1983
Effect of chronic treatment with prazosin and L-arginine on the elevation of blood pressure during cold exposure.
    Pharmacology, 1994, Volume: 49, Issue:6

    Topics: Adrenal Glands; Angiotensin II; Animals; Arginine; Blood Pressure; Cardiomegaly; Cold Temperature; Epinephrine; Hypertension; Levodopa; Male; Prazosin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological; Thyroid Hormones; Tyrosine 3-Monooxygenase

1994
Noradrenergic alpha-1 and alpha-2 antagonists block L-dopa-induced air-stepping in neonatal rats.
    Brain research. Developmental brain research, 1994, Jun-17, Volume: 79, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Dioxanes; Female; Idazoxan; Levodopa; Locomotion; Male; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Stereotyped Behavior

1994
Overstimulation of the alpha1B-adrenergic receptor causes a "seizure plus" syndrome.
    Nature medicine, 2001, Volume: 7, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Brain; Cerebral Cortex; Disease Models, Animal; Dopamine Agents; Epilepsy, Tonic-Clonic; Humans; Inclusion Bodies; Levodopa; Mice; Nerve Tissue Proteins; Neurodegenerative Diseases; Parkinsonian Disorders; Prazosin; Receptors, Adrenergic, alpha-1; Shy-Drager Syndrome; Syndrome; Synucleins; Tyrosine 3-Monooxygenase

2001
An antihypokinesic action of alpha2-adrenoceptors upon MPTP-induced behaviour deficits in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Clonidine; Dopamine; Dopamine Agonists; Drug Interactions; Drug Therapy, Combination; Guanfacine; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neurons; Parkinsonian Disorders; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Yohimbine

2003
Benzo(alpha)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways.
    Life sciences, 2006, Jun-20, Volume: 79, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Benzo(a)pyrene; Catecholamines; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Dexmedetomidine; Epinephrine; Gene Expression Regulation, Enzymologic; Guanethidine; Levodopa; Male; Oxidoreductases; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic; Reserpine; RNA, Messenger; Signal Transduction; Sympatholytics; Up-Regulation

2006
Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic alpha-Antagonists; Animals; Benserazide; Brain Injuries; Dihydroxyphenylalanine; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; Prazosin; Receptors, Adrenergic, alpha

2009