Page last updated: 2024-08-21

isoxazoles and mofezolac

isoxazoles has been researched along with mofezolac in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.45)18.7374
1990's16 (51.61)18.2507
2000's7 (22.58)29.6817
2010's4 (12.90)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y1
Ichiki, T; Kodama, R; Kuwasaki, E; Kuwata, M; Satoh, K; Sone, H; Yamamoto, N; Yamashita, K1
Aoki, Y; Hashimoto, Y; Kiguchi, M; Kuwata, M; Okazaki, S; Shimpo, K; Takeuchi, M; Yamashita, K1
Araki, E; Ichiki, T; Katsuta, T; Kodama, R; Masunaga, A; Ohkubo, M; Yamashita, K1
Ikebuchi, K; Katayama, S; Koida, M; Shinomiya, M; Yamakita, O; Yoshida, R2
Fujii, S; Furukawa, S; Haguro, S; Morinaga, T; Morino, K; Toteno, I; Yamakita, O1
Fuchigami, K; Kodama, R; Matsunaga, K; Otsuka, T; Sameshima, K; Yamakita, O1
Furukawa, A; Ohuchida, A2
Katoh, S; Matsuo, K; Takemoto, M; Yoshida, R1
Iwata, M; Kiguchi, M; Nasu, Y; Shimpo, K; Takeuchi, M; Yada, H; Yamashita, K1
Furukawa, H; Ichiki, T; Kodama, R; Kuwata, M; Nasu, Y; Satoh, K; Sone, H; Yamashita, K1
Ogawa, K; Yamawaki, I1
Maniwa, M; Marunaka, T1
Kusuhara, H; Matsuyuki, H; Okumoto, T2
Goto, K; Imayoshi, T; Kusuhara, H; Matsuyuki, H; Ochi, H; Okumoto, T; Yasunaga, Y1
Itoh, M; Kawamori, T; Kitamura, T; Matsuura, M; Noda, T; Sugimura, T; Uchiya, N; Wakabayashi, K1
Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H1
Fujita, H; Morita, I; Sato, T; Tanaka, N1
Itoh, M; Kitamura, T; Matsuura, M; Noda, T; Wakabayashi, K1
Horiuchi, Y; Mano, Y; Morita, I; Muneta, T; Nakahama, K; Onodera, M1
Kitamura, T; Matsuura, M; Mutoh, M; Niho, N; Sato, H; Sugimura, T; Takahashi, M; Wakabayashi, K1
Fujikawa, Y; Itonaga, I; Kawashima, M; Takita, C; Tsumura, H1
Armen, RS; Cingolani, G; Di Mauro, G; Ferorelli, S; Fortuna, CG; Panella, A; Perrone, MG; Scilimati, A; Smith, WL; Vitale, P1
Boccarelli, A; Bonaccorso, C; Campanella, F; Coluccia, M; Di Mauro, G; Ferorelli, S; Fortuna, CG; Pannunzio, A; Perrone, MG; Scilimati, A; Vitale, P1
Boccarelli, A; Cabral, LM; de Pádula, M; Di Mauro, GD; Ferorelli, S; Fortuna, CG; Iaselli, M; Miciaccia, M; Pati, ML; Perrone, MG; Rodrigues Pereira da Silva, LC; Sathler, PC; Scilimati, A; Souza Domingos, TF; Vacca, A; Vitale, P1
Aleem, AM; Ferorelli, S; Fortuna, CG; Iaselli, MC; Marnett, LJ; Miciaccia, M; Pati, ML; Perrone, MG; Scilimati, A1
Azab, AN; Boyko, M; Ferorelli, S; Kaplanski, J; Perrone, MG; Rostevanov, IS; Scilimati, A; Zlotnik, A1
Araújo, CDCB; Bonaccorso, C; Cabral, LM; da Silva, LCRP; de Almeida, GS; de Pádula, M; Ferorelli, S; Fortuna, CG; Miciaccia, M; Perrone, MG; Sathler, PC; Scilimati, A; Souza Domingos, TF; Vitale, P1

Other Studies

31 other study(ies) available for isoxazoles and mofezolac

ArticleYear
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 95, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Isoxazoles; Mice; Organ Size; Oxazoles; Platelet Aggregation Inhibitors; Rabbits; Rats

1990
Acute toxicity tests of mofezolac (N-22) in mice and rats.
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Female; Gastrointestinal Diseases; Injections, Intraperitoneal; Injections, Subcutaneous; Isoxazoles; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Rats; Rats, Inbred Strains

1990
[Three-month oral subacute toxicity study of mofezolac (N-22) in rats].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Analysis; Drinking; Eating; Erythrocyte Count; Female; Ileal Diseases; Isoxazoles; Jejunal Diseases; Male; Organ Size; Rats; Rats, Inbred Strains; Ulcer; Weight Gain

1990
[Fifty two-week chronic oral toxicity study of mofezolac (N-22) in beagle dogs].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Female; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Isoxazoles; Male; Ulcer

1990
[Reproductive and developmental toxicity study of mofezolac (N-22) (1)--Study by oral administration of N-22 prior to and early stages of pregnancy in rats].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Embryonic and Fetal Development; Female; Fertility; Isoxazoles; Male; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Reproduction

1990
[Reproductive and developmental toxicity study of mofezolac (N-22) (2)--Study by oral administration of N-22 during the period of fetal organogenesis in rats].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Coccyx; Embryonic and Fetal Development; Female; Gestational Age; Isoxazoles; Pregnancy; Rats; Rats, Inbred Strains; Reproduction; Sternum

1990
[Reproductive and developmental toxicity study of mofezolac (N-22) (3)--Teratogenicity study in rabbits by oral administration].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Embryonic and Fetal Development; Female; Fetal Resorption; Gestational Age; Isoxazoles; Male; Pregnancy; Rabbits; Reproduction

1990
[Reproductive and developmental toxicity study of mofezolac (N-22) (4)--Study by oral administration of N-22 during the perinatal and lactation periods in rats].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Eating; Embryonic and Fetal Development; Female; Fetal Death; Isoxazoles; Lactation; Litter Size; Male; Postpartum Period; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Reproduction; Weight Gain

1990
Mutagenicity tests of mofezolac (N-22).
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Fibroblasts; Isoxazoles; Lung; Mutagenesis; Mutagenicity Tests; Salmonella typhimurium

1990
Micronucleus test of mofezolac (N-22).
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Erythrocytes, Abnormal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenesis

1990
[Antigenicity test of mofezolac (N-22)].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Female; Freund's Adjuvant; Guinea Pigs; Hemagglutination Tests; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Inbred Strains

1990
[Three-month subacute oral toxicity study of mofezolac (N-22) in dogs].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Body Weight; Dogs; Duodenal Ulcer; Erythrocyte Count; Female; Isoxazoles; Male; Organ Size; Stomach Ulcer

1990
[Fifty two-week chronic oral toxicity study of mofezolac (N-22) in rats].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 2

    Topics: Administration, Oral; Anemia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Gastrointestinal Diseases; Isoxazoles; Kidney Diseases; Liver; Male; Rats; Rats, Inbred Strains

1990
Synthesis and biological activity of the metabolites of [3,4-bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:8

    Topics: Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Oxazoles

1988
High-performance of liquid chromatographic determination of [3,4-di-(4-methoxyphenyl)-5-isoxazolyl]acetic acid and its metabolites in human plasma and urine.
    Journal of chromatography, 1987, Nov-27, Volume: 422

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Spectrophotometry, Ultraviolet

1987
Effects of nonsteroidal anti-inflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells.
    Prostaglandins, 1997, Volume: 54, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoxazoles; Leukocytes, Mononuclear; RNA, Messenger; Sialoglycoproteins

1997
Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
    Prostaglandins & other lipid mediators, 1998, Volume: 55, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Pain; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; RNA, Messenger

1998
Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
    Prostaglandins & other lipid mediators, 1998, Volume: 56, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Inbred Strains; Pain; Prostaglandin-Endoperoxide Synthases; Time Factors

1998
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
    Carcinogenesis, 2002, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Genes, APC; Intestinal Neoplasms; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides

2002
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:10

    Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:3

    Topics: Cell Differentiation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Fetal Blood; Hematopoietic Stem Cells; Humans; Infant, Newborn; Isoenzymes; Isoxazoles; Megakaryocytes; Membrane Proteins; Nitrobenzenes; Platelet Count; Pluripotent Stem Cells; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stem Cell Factor; Sulfonamides; Thrombopoiesis; Thrombopoietin; Thromboxane A2

2004
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.
    International journal of cancer, 2004, Apr-20, Volume: 109, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Genes, APC; Indomethacin; Intestinal Neoplasms; Intestinal Polyps; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Knockout; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2004
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2004, Volume: 53, Issue:6

    Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Dexamethasone; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Interleukin-1; Isoenzymes; Isoxazoles; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Synovial Membrane; Time Factors

2004
Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.
    Cancer science, 2006, Volume: 97, Issue:10

    Topics: Animals; Azoxymethane; Carcinoma; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Isoxazoles; Male; Membrane Proteins; Rats; Rats, Inbred F344

2006
The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro.
    Modern rheumatology, 2009, Volume: 19, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Celecoxib; Cell Growth Processes; Cell Survival; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Humans; Indomethacin; Isoxazoles; Macrophage Colony-Stimulating Factor; Osteoclasts; Pyrazoles; RANK Ligand; Stem Cells; Sulfonamides; Time Factors

2009
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship

2017
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.
    European journal of medicinal chemistry, 2017, Dec-01, Volume: 141

    Topics: Animals; Blood-Brain Barrier; Cell Line; Central Nervous System; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Galactose; Glucose Transporter Type 1; Humans; Isoxazoles; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship

2017
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
    European journal of medicinal chemistry, 2019, Feb-15, Volume: 164

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Multiple Myeloma; Platelet Aggregation Inhibitors; Protein Binding; Structure-Activity Relationship

2019
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection.
    European journal of medicinal chemistry, 2019, Oct-01, Volume: 179

    Topics: Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Fluorescent Dyes; HEK293 Cells; Humans; Isoxazoles; Molecular Structure; Optical Imaging; Ovarian Neoplasms; Structure-Activity Relationship

2019
Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats.
    Neuroscience letters, 2020, 10-15, Volume: 737

    Topics: Animals; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Ischemic Stroke; Isoxazoles; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2020
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Coagulation; Chlorocebus aethiops; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Erythrocytes; Humans; Isoxazoles; Models, Molecular; Protein Binding; Protein Multimerization; Structure-Activity Relationship; Thrombosis; Vero Cells

2021
chemdatabank.com