isoxazoles and mofezolac
isoxazoles has been researched along with mofezolac in 31 studies
Research
Studies (31)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (6.45) | 18.7374 |
1990's | 16 (51.61) | 18.2507 |
2000's | 7 (22.58) | 29.6817 |
2010's | 4 (12.90) | 24.3611 |
2020's | 2 (6.45) | 2.80 |
Authors
Authors | Studies |
---|---|
Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y | 1 |
Ichiki, T; Kodama, R; Kuwasaki, E; Kuwata, M; Satoh, K; Sone, H; Yamamoto, N; Yamashita, K | 1 |
Aoki, Y; Hashimoto, Y; Kiguchi, M; Kuwata, M; Okazaki, S; Shimpo, K; Takeuchi, M; Yamashita, K | 1 |
Araki, E; Ichiki, T; Katsuta, T; Kodama, R; Masunaga, A; Ohkubo, M; Yamashita, K | 1 |
Ikebuchi, K; Katayama, S; Koida, M; Shinomiya, M; Yamakita, O; Yoshida, R | 2 |
Fujii, S; Furukawa, S; Haguro, S; Morinaga, T; Morino, K; Toteno, I; Yamakita, O | 1 |
Fuchigami, K; Kodama, R; Matsunaga, K; Otsuka, T; Sameshima, K; Yamakita, O | 1 |
Furukawa, A; Ohuchida, A | 2 |
Katoh, S; Matsuo, K; Takemoto, M; Yoshida, R | 1 |
Iwata, M; Kiguchi, M; Nasu, Y; Shimpo, K; Takeuchi, M; Yada, H; Yamashita, K | 1 |
Furukawa, H; Ichiki, T; Kodama, R; Kuwata, M; Nasu, Y; Satoh, K; Sone, H; Yamashita, K | 1 |
Ogawa, K; Yamawaki, I | 1 |
Maniwa, M; Marunaka, T | 1 |
Kusuhara, H; Matsuyuki, H; Okumoto, T | 2 |
Goto, K; Imayoshi, T; Kusuhara, H; Matsuyuki, H; Ochi, H; Okumoto, T; Yasunaga, Y | 1 |
Itoh, M; Kawamori, T; Kitamura, T; Matsuura, M; Noda, T; Sugimura, T; Uchiya, N; Wakabayashi, K | 1 |
Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H | 1 |
Fujita, H; Morita, I; Sato, T; Tanaka, N | 1 |
Itoh, M; Kitamura, T; Matsuura, M; Noda, T; Wakabayashi, K | 1 |
Horiuchi, Y; Mano, Y; Morita, I; Muneta, T; Nakahama, K; Onodera, M | 1 |
Kitamura, T; Matsuura, M; Mutoh, M; Niho, N; Sato, H; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
Fujikawa, Y; Itonaga, I; Kawashima, M; Takita, C; Tsumura, H | 1 |
Armen, RS; Cingolani, G; Di Mauro, G; Ferorelli, S; Fortuna, CG; Panella, A; Perrone, MG; Scilimati, A; Smith, WL; Vitale, P | 1 |
Boccarelli, A; Bonaccorso, C; Campanella, F; Coluccia, M; Di Mauro, G; Ferorelli, S; Fortuna, CG; Pannunzio, A; Perrone, MG; Scilimati, A; Vitale, P | 1 |
Boccarelli, A; Cabral, LM; de Pádula, M; Di Mauro, GD; Ferorelli, S; Fortuna, CG; Iaselli, M; Miciaccia, M; Pati, ML; Perrone, MG; Rodrigues Pereira da Silva, LC; Sathler, PC; Scilimati, A; Souza Domingos, TF; Vacca, A; Vitale, P | 1 |
Aleem, AM; Ferorelli, S; Fortuna, CG; Iaselli, MC; Marnett, LJ; Miciaccia, M; Pati, ML; Perrone, MG; Scilimati, A | 1 |
Azab, AN; Boyko, M; Ferorelli, S; Kaplanski, J; Perrone, MG; Rostevanov, IS; Scilimati, A; Zlotnik, A | 1 |
Araújo, CDCB; Bonaccorso, C; Cabral, LM; da Silva, LCRP; de Almeida, GS; de Pádula, M; Ferorelli, S; Fortuna, CG; Miciaccia, M; Perrone, MG; Sathler, PC; Scilimati, A; Souza Domingos, TF; Vitale, P | 1 |
Other Studies
31 other study(ies) available for isoxazoles and mofezolac
Article | Year |
---|---|
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Isoxazoles; Mice; Organ Size; Oxazoles; Platelet Aggregation Inhibitors; Rabbits; Rats | 1990 |
Acute toxicity tests of mofezolac (N-22) in mice and rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Female; Gastrointestinal Diseases; Injections, Intraperitoneal; Injections, Subcutaneous; Isoxazoles; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Rats; Rats, Inbred Strains | 1990 |
[Three-month oral subacute toxicity study of mofezolac (N-22) in rats].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Analysis; Drinking; Eating; Erythrocyte Count; Female; Ileal Diseases; Isoxazoles; Jejunal Diseases; Male; Organ Size; Rats; Rats, Inbred Strains; Ulcer; Weight Gain | 1990 |
[Fifty two-week chronic oral toxicity study of mofezolac (N-22) in beagle dogs].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Female; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Isoxazoles; Male; Ulcer | 1990 |
[Reproductive and developmental toxicity study of mofezolac (N-22) (1)--Study by oral administration of N-22 prior to and early stages of pregnancy in rats].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Embryonic and Fetal Development; Female; Fertility; Isoxazoles; Male; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Reproduction | 1990 |
[Reproductive and developmental toxicity study of mofezolac (N-22) (2)--Study by oral administration of N-22 during the period of fetal organogenesis in rats].
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Coccyx; Embryonic and Fetal Development; Female; Gestational Age; Isoxazoles; Pregnancy; Rats; Rats, Inbred Strains; Reproduction; Sternum | 1990 |
[Reproductive and developmental toxicity study of mofezolac (N-22) (3)--Teratogenicity study in rabbits by oral administration].
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Embryonic and Fetal Development; Female; Fetal Resorption; Gestational Age; Isoxazoles; Male; Pregnancy; Rabbits; Reproduction | 1990 |
[Reproductive and developmental toxicity study of mofezolac (N-22) (4)--Study by oral administration of N-22 during the perinatal and lactation periods in rats].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Eating; Embryonic and Fetal Development; Female; Fetal Death; Isoxazoles; Lactation; Litter Size; Male; Postpartum Period; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Reproduction; Weight Gain | 1990 |
Mutagenicity tests of mofezolac (N-22).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Fibroblasts; Isoxazoles; Lung; Mutagenesis; Mutagenicity Tests; Salmonella typhimurium | 1990 |
Micronucleus test of mofezolac (N-22).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Erythrocytes, Abnormal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenesis | 1990 |
[Antigenicity test of mofezolac (N-22)].
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Female; Freund's Adjuvant; Guinea Pigs; Hemagglutination Tests; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Inbred Strains | 1990 |
[Three-month subacute oral toxicity study of mofezolac (N-22) in dogs].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Body Weight; Dogs; Duodenal Ulcer; Erythrocyte Count; Female; Isoxazoles; Male; Organ Size; Stomach Ulcer | 1990 |
[Fifty two-week chronic oral toxicity study of mofezolac (N-22) in rats].
Topics: Administration, Oral; Anemia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Gastrointestinal Diseases; Isoxazoles; Kidney Diseases; Liver; Male; Rats; Rats, Inbred Strains | 1990 |
Synthesis and biological activity of the metabolites of [3,4-bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid.
Topics: Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Oxazoles | 1988 |
High-performance of liquid chromatographic determination of [3,4-di-(4-methoxyphenyl)-5-isoxazolyl]acetic acid and its metabolites in human plasma and urine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Spectrophotometry, Ultraviolet | 1987 |
Effects of nonsteroidal anti-inflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoxazoles; Leukocytes, Mononuclear; RNA, Messenger; Sialoglycoproteins | 1997 |
Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Pain; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; RNA, Messenger | 1998 |
Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Inbred Strains; Pain; Prostaglandin-Endoperoxide Synthases; Time Factors | 1998 |
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Genes, APC; Intestinal Neoplasms; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides | 2002 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis.
Topics: Cell Differentiation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Fetal Blood; Hematopoietic Stem Cells; Humans; Infant, Newborn; Isoenzymes; Isoxazoles; Megakaryocytes; Membrane Proteins; Nitrobenzenes; Platelet Count; Pluripotent Stem Cells; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stem Cell Factor; Sulfonamides; Thrombopoiesis; Thrombopoietin; Thromboxane A2 | 2004 |
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Genes, APC; Indomethacin; Intestinal Neoplasms; Intestinal Polyps; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Knockout; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2004 |
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Dexamethasone; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Interleukin-1; Isoenzymes; Isoxazoles; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Synovial Membrane; Time Factors | 2004 |
Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.
Topics: Animals; Azoxymethane; Carcinoma; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Isoxazoles; Male; Membrane Proteins; Rats; Rats, Inbred F344 | 2006 |
The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Celecoxib; Cell Growth Processes; Cell Survival; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Humans; Indomethacin; Isoxazoles; Macrophage Colony-Stimulating Factor; Osteoclasts; Pyrazoles; RANK Ligand; Stem Cells; Sulfonamides; Time Factors | 2009 |
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).
Topics: Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship | 2017 |
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.
Topics: Animals; Blood-Brain Barrier; Cell Line; Central Nervous System; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Galactose; Glucose Transporter Type 1; Humans; Isoxazoles; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2017 |
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Multiple Myeloma; Platelet Aggregation Inhibitors; Protein Binding; Structure-Activity Relationship | 2019 |
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection.
Topics: Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Fluorescent Dyes; HEK293 Cells; Humans; Isoxazoles; Molecular Structure; Optical Imaging; Ovarian Neoplasms; Structure-Activity Relationship | 2019 |
Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats.
Topics: Animals; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Ischemic Stroke; Isoxazoles; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2020 |
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Coagulation; Chlorocebus aethiops; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Erythrocytes; Humans; Isoxazoles; Models, Molecular; Protein Binding; Protein Multimerization; Structure-Activity Relationship; Thrombosis; Vero Cells | 2021 |