Page last updated: 2024-08-21

isoxazoles and hp 873

isoxazoles has been researched along with hp 873 in 100 studies

Research

Studies (100)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (9.00)	18.2507
2000's	24 (24.00)	29.6817
2010's	55 (55.00)	24.3611
2020's	12 (12.00)	2.80

Authors

Authors	Studies
Brecher, MB; Chi, E; Grasing, K; Hubbard, JW; Sainati, SM	1
Conway, PG; Corbett, R; Cornfeldt, M; Rush, DK; Strupczewski, JT; Szewczak, MR; Wilmot, CA	1
Mutlib, AE; Strupczewski, JT	1
Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT	1
Bordeau, KJ; Chiang, Y; Conway, PG; Corbett, R; Glamkowski, EJ; Hartman, HB; Helsley, GC; Strupczewski, JT; Szewczak, MR; Wilmot, CA	1
Chesson, SM; Mutlib, AE; Strupczewski, JT	1
Brougham, LR; Conway, PG; Ellis, DB; Roehr, JE; Szczepanik, AM; Wilmot, CA	1
Cai, J; Hartman, HB; Kerman, LL; Kongsamut, S; Roehr, JE; Sandrasagra, A; Tang, L; Weissensee, P	1
Klein, JT; Mutlib, AE	1
Jain, KK	1
Hoyer, D; Kalkman, HO; Subramanian, N	1
Albert, MJ; Baldessarini, RJ; Centorrino, F; Kelleher, JP	1
Kalkman, HO; Subramanian, N	1
Dai, J; Ichikawa, J; Li, Z; Meltzer, HY	1
Kalkman, HO; Loetscher, E	1
Enz, A; Gemperle, AY; Lüthi, A; Olpe, HR; Pozza, MF	1
Feuerbach, D; Kalkman, HO; Lötscher, E; Schoeffter, P	1
Gemperle, AY; McAllister, KH; Olpe, HR	1
Barr, AM; Geyer, MA; Markou, A; Powell, SB	1
Albers, LJ; Musenga, A; Raggi, MA	1
Lavedan, C; Polymeropoulos, MH; Volpi, S; Wolfgang, CD	1
Potkin, SG	1
Cutler, AJ; Polymeropoulos, MH; Weiden, PJ; Wolfgang, CD	1
Cutler, AJ; Hamilton, J; Kalali, AH; Weiden, PJ; Wolfgang, CD	1
Di Marino, M; Kane, JM; Laska, E; Lauriello, J; Wolfgang, CD	1
Litman, RE; Potkin, SG; Torres, R; Wolfgang, CD	1
Hamilton, J; Heaton, C; Lannan, R; Lavedan, C; Licamele, L; Mack, K; Polymeropoulos, MH; Thompson, A; Volpi, S; Wolfgang, CD	1
Hamilton, JB; Heaton, C; Lannan, R; Lavedan, C; Licamele, L; Mack, K; Polymeropoulos, MH; Volpi, S; Wolfgang, CD	1
Kumar, R; Sachdev, PS	1
Lavedan, C; Licamele, L; Malhotra, AK; Potkin, SG; Volpi, S	1
Citrome, L	5
Scott, LJ	1
Cutler, AJ	1
Lavedan, C; Thompson, A; Volpi, S	1
Caccia, S; Nobili, A; Pasina, L	1
Caballero, J; Marino, J	1
Janicak, PG; Rado, J	1
Bishop, DL; Bishop, JR	1
Richelson, E	1
Roman, MW	1
Dopheide, JA	1
Arif, SA; Mitchell, MM	1
Howland, RH	1
Crabtree, BL; Montgomery, J	1
Citrome, L; Hochfeld, M; Meng, X	1
Conley, RR; Fijal, BA; Hoffmann, VP; Houston, JP; Kinon, BJ; Stauffer, VL; Witte, MM; Zhao, F	1
Grant, JS; Keltner, NL; Moore, RL	1
Bhosale, SH; Dash, RC; Kanhed, AM; Mahadik, KR; Shelke, SM; Suryawanshi, MR	1
Citrome, L; Hochfeld, M; Meng, X; Stahl, SM	1
Knoepflmacher, D; Shapley, L; Turner, EH	1
Weiden, PJ	1
Drolet, B; Patoine, D; Pilote, S; Simard, C; Vigneault, P	1
Cvelich, RG; Kincaid, BR; Muzyk, AJ; Preud'homme, XA	1
Hopkins, CR	1
Stahl, SM; Tarazi, FI	1
Correll, CU; De Hert, M; Detraux, J; Sweers, K; van Winkel, R; Yu, W	1
Bobo, WV	1
Hochfeld, M; Meng, X; Potkin, SG; Preskorn, S	1
Cutler, AJ; Kalali, AH; Kunovac, J; Mattingly, GW; Meng, X	1
Barr, AM; Boyda, HN; Hawkes, E; Honer, WG; Jin, CH; Pang, CC; Procyshyn, RM; Wong, D	1
Freeman, SA	1
Parekh, JM; Sanyal, M; Shrivastav, PS; Yadav, M	1
Amrutheshwar, R; Dkhar, SA; George, M; Kattimani, S; Rajkumar, RP	1
Fan, Y; He, X; Jia, M; Li, J; Li, W; Liu, M; Zhou, Y	1
Preskorn, SH	1
Dargani, NV; Malhotra, AK	1
Stahl, SM	1
Mandpe, L; Pokharkar, V	1
Alva, G; Brams, M; Citrome, L; Glick, ID; Hochfeld, M; Jackson, R; Kianifard, F; Mattingly, G; Meng, X; Pestreich, L; Weiden, PJ; Winseck, A	1
Morrissette, DA; Stahl, SM	1
Alva, G; Citrome, L; Glick, ID; Jackson, R; Kianifard, F; Mattingly, G; Meng, X; Weiden, PJ; Winseck, A	1
Blackford, M; Gunkelman, S; Pfeiffer, S	1
Geerts, H; Potkin, S; Roberts, P; Spiros, A	1
Mandrioli, R; Mercolini, L; Protti, M	1
Green, AI; Khokhar, JY	1
Hartwig, J; Kirschning, A	1
Ahmed, S; Han, G; Mancione, L; Manning, R; Mayo, MG; Ryan, JM; Weiden, PJ; Wolfgang, CD	1
Arnold, JG; Bowden, CL; Martinez, M; Prihoda, TJ; Singh, V	1
Klein-Schwartz, W; Stassinos, G	1
Ballon, JS; Contreras, I; Freyberg, R; Freyberg, Z; Leibel, RL; Lieberman, JA; Mayer, LE; Pajvani, UB; Rosenbaum, M	1
Gangu Naidu, C; Madhusudhan Rao, V; Nagesh Kumar, K; Nageswara Rao, R; Padiya, R; Prasada Rao, AV	1
Beulah, TE; Maheswari, E; Singh, H; Subeesh, V; Swaroop, AM	1
Bhasin, B; Londhe, VY	1
Joshi, SV; Kalyankar, GG; Lodha, SR; Patel, EP; Vyas, BA	1
Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S	1
Narala, A; Suram, D; Veerabrahma, K	2
Danek, PJ; Daniel, WA; Wójcikowski, J	2
Asamoah, AL; Gosal, R; Grossberg, GT; Nair, A; Salem, A	1
Hewitt, T; Khokhar, JY; Lalonde, J; Perreault, ML; St-Denis, M; Thériault, RK	1
Danek, PJ; Daniel, WA; Kuban, W	1
Choi, BH; Choi, JS; Hahn, SJ; Lee, HJ	1
Chubanov, V; Gudermann, T; Hill, K; Nörenberg, W; Rössig, A; Schaefer, M; Weidenbach, S; Zierler, S	1
Earle, RR; Gadela, VR	1

Reviews

30 review(s) available for isoxazoles and hp 873

Article	Year
An assessment of iloperidone for the treatment of schizophrenia. Expert opinion on investigational drugs, 2000, Volume: 9, Issue:12 Topics: Animals; Antipsychotic Agents; Clinical Trials as Topic; Humans; Isoxazoles; Piperidines; Schizophrenia	2000
Advances in atypical antipsychotics for the treatment of schizophrenia: new formulations and new agents. CNS drugs, 2002, Volume: 16, Issue:4 Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dosage Forms; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quinolones; Risperidone; Schizophrenia; Thiazoles	2002
Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert opinion on investigational drugs, 2008, Volume: 17, Issue:1 Topics: Animals; Antipsychotic Agents; Clinical Trials as Topic; Drug Design; Drug Evaluation, Preclinical; Humans; Isoxazoles; Marketing; Piperidines; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Schizophrenia; Structure-Activity Relationship	2008
Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2 Suppl 1 Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Double-Blind Method; Female; Humans; Isoxazoles; Long QT Syndrome; Male; Middle Aged; Patient Dropouts; Piperidines; Prospective Studies; Psychotic Disorders; Randomized Controlled Trials as Topic; Schizophrenia; Weight Gain	2008
Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2 Suppl 1 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Drug Administration Schedule; Female; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperidines; Prospective Studies; Randomized Controlled Trials as Topic; Schizophrenia	2008
Akathisia and second-generation antipsychotic drugs. Current opinion in psychiatry, 2009, Volume: 22, Issue:3 Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Prevalence; Psychomotor Agitation; Psychotic Disorders; Quetiapine Fumarate; Quinolones; Risk Factors; Risperidone; Sulpiride; Thiazoles	2009
Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialised second-generation antipsychotic. International journal of clinical practice, 2009, Volume: 63, Issue:8 Topics: Antipsychotic Agents; Clinical Trials, Phase III as Topic; Drug Labeling; Humans; Isoxazoles; Piperidines; Randomized Controlled Trials as Topic; Sample Size; Schizophrenia; Treatment Outcome	2009
Iloperidone: in schizophrenia. CNS drugs, 2009, Volume: 23, Issue:10 Topics: Humans; Internationality; Isoxazoles; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic; Schizophrenia; Schizophrenic Psychology	2009
Iloperidone: a new option for the treatment of schizophrenia. Expert review of neurotherapeutics, 2009, Volume: 9, Issue:12 Topics: Antipsychotic Agents; Brief Psychiatric Rating Scale; Clinical Trials as Topic; Confidence Intervals; Humans; Isoxazoles; Kaplan-Meier Estimate; Longitudinal Studies; Piperidines; Schizophrenia	2009
New atypical antipsychotics for schizophrenia: iloperidone. Drug design, development and therapy, 2010, Feb-18, Volume: 4 Topics: Antipsychotic Agents; Clinical Trials as Topic; Humans; Isoxazoles; Piperidines; Schizophrenia	2010
Iloperidone for the treatment of schizophrenia. The Annals of pharmacotherapy, 2010, Volume: 44, Issue:5 Topics: Antipsychotic Agents; Humans; Isoxazoles; Piperidines; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome	2010
Iloperidone for schizophrenia. Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:12 Topics: Animals; Antipsychotic Agents; Dopamine Antagonists; Drug Approval; Humans; Isoxazoles; Pharmacogenetics; Piperidines; Schizophrenia; Serotonin Antagonists; Treatment Outcome	2010
Iloperidone for the treatment of schizophrenia. Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:8 Topics: Animals; Antipsychotic Agents; Drug Interactions; Evidence-Based Medicine; Humans; Isoxazoles; Pharmacogenetics; Piperidines; Precision Medicine; Schizophrenia; Schizophrenic Psychology; Treatment Outcome	2010
New antipsychotic drugs: how do their receptor-binding profiles compare? The Journal of clinical psychiatry, 2010, Volume: 71, Issue:9 Topics: Antipsychotic Agents; Brain; Clozapine; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; Paliperidone Palmitate; Piperidines; Pyrimidines; Receptors, Neurotransmitter	2010
Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion. Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:12 Topics: Adult; Animals; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Half-Life; Humans; Isoxazoles; Piperidines; Receptors, Adrenergic, alpha-1; Schizophrenia	2010
Iloperidone: A new drug for the treatment of schizophrenia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, Feb-15, Volume: 68, Issue:4 Topics: Antipsychotic Agents; Drug Administration Schedule; Drug Interactions; Humans; Isoxazoles; Piperidines; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Schizophrenia	2011
Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics. Postgraduate medicine, 2011, Volume: 123, Issue:2 Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles	2011
Iloperidone for the management of adults with schizophrenia. Clinical therapeutics, 2011, Volume: 33, Issue:3 Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Humans; Isoxazoles; Piperidines; Schizophrenia; Treatment Outcome	2011
Iloperidone: a clinical overview. The Journal of clinical psychiatry, 2011, Volume: 72 Suppl 1 Topics: Antipsychotic Agents; Electrocardiography; Heart Rate; Humans; Isoxazoles; Long QT Syndrome; Piperidines; Schizophrenia; Treatment Outcome; Weight Gain	2011
Iloperidone for the treatment of schizophrenia: an updated clinical review. Clinical schizophrenia & related psychoses, 2012, Volume: 6, Issue:1 Topics: Ambulatory Care; Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Approval; Hospitalization; Humans; Isoxazoles; Piperidines; Schizophrenia; Schizophrenic Psychology; Secondary Prevention; Treatment Outcome	2012
ACS chemical neuroscience molecule spotlight on Fanapt. ACS chemical neuroscience, 2010, Jun-16, Volume: 1, Issue:6 Topics: Antipsychotic Agents; Clinical Trials, Phase III as Topic; Device Approval; Dopamine Agonists; Humans; Isoxazoles; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT2 Receptor Antagonists; United States; United States Food and Drug Administration	2010
Iloperidone, asenapine and lurasidone: a primer on their current status. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:13 Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles; United States; United States Food and Drug Administration	2012
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis. CNS drugs, 2012, Sep-01, Volume: 26, Issue:9 Topics: Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lipid Metabolism; Lurasidone Hydrochloride; Paliperidone Palmitate; Piperidines; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Weight Gain	2012
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults. Expert review of clinical pharmacology, 2013, Volume: 6, Issue:1 Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles	2013
Newer antipsychotics and upcoming molecules for schizophrenia. European journal of clinical pharmacology, 2013, Volume: 69, Issue:8 Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperazines; Piperidines; Schizophrenia; Thiazoles	2013
Safety profile of iloperidone in the treatment of schizophrenia. Expert opinion on drug safety, 2014, Volume: 13, Issue:2 Topics: Antipsychotic Agents; Humans; Isoxazoles; Piperidines; Schizophrenia; Treatment Outcome	2014
Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy. CNS spectrums, 2014, Volume: 19, Issue:5 Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Clozapine; Dibenzocycloheptenes; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Humans; Impulsive Behavior; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Polypharmacy; Psychotic Disorders; Quetiapine Fumarate; Receptors, Dopamine D2; Risperidone; Thiazoles; Violence	2014
Novel Atypical Antipsychotics: Metabolism and Therapeutic Drug Monitoring (TDM). Current drug metabolism, 2015, Volume: 16, Issue:2 Topics: Animals; Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Drug Design; Drug Monitoring; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; United States; United States Food and Drug Administration	2015
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia. The American journal of psychiatry, 2020, 04-01, Volume: 177, Issue:4 Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes	2020
An update on the efficacy and safety of iloperidone as a schizophrenia therapy. Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:15 Topics: Antipsychotic Agents; Humans; Isoxazoles; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Schizophrenia; Weight Gain	2020

Trials

17 trial(s) available for isoxazoles and hp 873

Article	Year
Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. Journal of clinical pharmacology, 1995, Volume: 35, Issue:7 Topics: Adolescent; Adult; Antipsychotic Agents; Biological Availability; Drug Tolerance; Food-Drug Interactions; Half-Life; Humans; Intestinal Absorption; Isoxazoles; Male; Metabolic Clearance Rate; Piperidines; Time Factors	1995
Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. Pharmacogenomics, 2008, Volume: 9, Issue:3 Topics: Adult; Antipsychotic Agents; Ciliary Neurotrophic Factor; Double-Blind Method; Female; Humans; Isoxazoles; Male; Piperidines; Placebos; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Racial Groups; Schizophrenia; Schizophrenic Psychology	2008
Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2 Suppl 1 Topics: Acute Disease; Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Schizophrenia; Thiazoles; Treatment Outcome	2008
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. Molecular psychiatry, 2009, Volume: 14, Issue:8 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; Double-Blind Method; Female; Genome-Wide Association Study; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Isoxazoles; Male; Middle Aged; Nerve Tissue Proteins; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Pseudogenes; Receptors, AMPA; Schizophrenia; Tenascin; Thiazoles; Transcription Factors; Young Adult	2009
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. Molecular psychiatry, 2009, Volume: 14, Issue:11 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Carrier Proteins; CELF Proteins; Cytoskeletal Proteins; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Linear Models; Linkage Disequilibrium; Long QT Syndrome; Male; Middle Aged; Neuregulins; Organic Anion Transporters; Pharmacogenetics; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Piperidines; Polymorphism, Single Nucleotide; RNA-Binding Proteins; Schizophrenia; Thiazoles; Young Adult	2009
Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. The Journal of clinical psychiatry, 2009, Volume: 70, Issue:6 Topics: Adult; Alleles; Antipsychotic Agents; Double-Blind Method; Female; Genetic Markers; Genotype; Humans; Isoxazoles; Likelihood Functions; Male; Middle Aged; Odds Ratio; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Probability; Psychiatric Status Rating Scales; Psychometrics; Schizophrenia; Thiazoles; Treatment Outcome	2009
Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone. Psychiatry research, 2010, Feb-28, Volume: 175, Issue:3 Topics: Analysis of Variance; Antipsychotic Agents; Female; Follow-Up Studies; Gene Frequency; Genotype; Humans; Isoxazoles; Male; Piperazines; Piperidines; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Schizophrenia; Thiazoles; Weight Gain	2010
Efficacy of iloperidone in schizophrenia: a PANSS five-factor analysis. Schizophrenia research, 2011, Volume: 131, Issue:1-3 Topics: Adolescent; Adult; Age Factors; Aged; Antipsychotic Agents; Cognition Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Factor Analysis, Statistical; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Treatment Outcome; Young Adult	2011
Analysis of gene variants previously associated with iloperidone response in patients with schizophrenia who are treated with risperidone. The Journal of clinical psychiatry, 2012, Volume: 73, Issue:3 Topics: Adult; Antipsychotic Agents; Apoptosis Regulatory Proteins; Benzodiazepines; Biomarkers, Pharmacological; Black or African American; Drug Resistance; Genotype; Humans; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Olanzapine; Piperidines; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Receptors, AMPA; Risperidone; Schizophrenia; White People	2012
Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials. Human psychopharmacology, 2012, Volume: 27, Issue:1 Topics: Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Labeling; Female; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Thiazoles; Treatment Outcome; Young Adult	2012
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone. Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:1 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult	2013
Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial. CNS spectrums, 2013, Volume: 18, Issue:1 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Female; Humans; India; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Piperazines; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Thiazoles; Time Factors; Treatment Outcome; United States; Young Adult	2013
A trial evaluating gradual- or immediate-switch strategies from risperidone, olanzapine, or aripiprazole to iloperidone in patients with schizophrenia. Schizophrenia research, 2014, Volume: 153, Issue:1-3 Topics: Adolescent; Adult; Analysis of Variance; Antipsychotic Agents; Aortic Bodies; Aripiprazole; Benzodiazepines; Cohort Studies; Drug Administration Schedule; Drug Substitution; Female; Humans; Isoxazoles; Male; Middle Aged; Olanzapine; Piperazines; Piperidines; Psychiatric Status Rating Scales; Quinolones; Risperidone; Schizophrenia; Surveys and Questionnaires; Treatment Outcome; Young Adult	2014
Switching to iloperidone: An omnibus of clinically relevant observations from a 12-week, open-label, randomized clinical trial in 500 persons with schizophrenia. Clinical schizophrenia & related psychoses, 2015, Volume: 8, Issue:4 Topics: Adult; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Dizziness; Female; Humans; Isoxazoles; Male; Olanzapine; Piperazines; Piperidines; Quinolones; Risperidone; Schizophrenia; Treatment Outcome	2015
A Randomized Trial of Iloperidone for Prevention of Relapse in Schizophrenia: The REPRIEVE Study. CNS drugs, 2016, Volume: 30, Issue:8 Topics: Adult; Antipsychotic Agents; Double-Blind Method; Female; Humans; Isoxazoles; Male; Piperidines; Recurrence; Schizophrenia; Secondary Prevention; Treatment Outcome	2016
An Open Trial of Iloperidone for Mixed Episodes in Bipolar Disorder. Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:5 Topics: Adult; Antipsychotic Agents; Arrhythmias, Cardiac; Bipolar Disorder; Female; Humans; Isoxazoles; Male; Piperidines; Treatment Outcome; Urinary Incontinence; Urinary Incontinence, Urge; Young Adult	2017
Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo. Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:5 Topics: Adolescent; Adult; Antipsychotic Agents; Blood Glucose; Body Weight; Double-Blind Method; Dyslipidemias; Eating; Energy Metabolism; Female; Glucose Tolerance Test; Healthy Volunteers; Humans; Insulin; Insulin Resistance; Isoxazoles; Lipids; Male; Obesity; Olanzapine; Piperidines; Weight Gain; Young Adult	2018

Other Studies

53 other study(ies) available for isoxazoles and hp 873

Article	Year
The pharmacological profile of iloperidone, a novel atypical antipsychotic agent. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3 Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Clozapine; Dopamine Antagonists; Haloperidol; Isoxazoles; Male; Mice; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Risperidone; Saimiri; Serotonin Antagonists	1995
Picogram determination of iloperidone in human plasma by solid-phase extraction and by high-performance liquid chromatography-selected-ion monitoring electrospray mass spectrometry. Journal of chromatography. B, Biomedical applications, 1995, Jul-21, Volume: 669, Issue:2 Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Isoxazoles; Mass Spectrometry; Piperidines; Reproducibility of Results	1995
Effects of atypical antipsychotic agents on social behavior in rodents. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior	1993
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873). Journal of medicinal chemistry, 1995, Mar-31, Volume: 38, Issue:7 Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine Antagonists; In Vitro Techniques; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship	1995
Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:9 Topics: Animals; Antipsychotic Agents; Bile; Biotransformation; Chromatography, Liquid; Dogs; Humans; In Vitro Techniques; Isoxazoles; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Piperidines; Rats; Rats, Wistar; Spectrophotometry, Infrared; Subcellular Fractions	1995
Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotic with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2 Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Brain; Dihydroxyphenylalanine; Dopamine Antagonists; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Serotonin Antagonists	1996
Iloperidone binding to human and rat dopamine and 5-HT receptors. European journal of pharmacology, 1996, Dec-19, Volume: 317, Issue:2-3 Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; CHO Cells; Cricetinae; Humans; Isoxazoles; Kinetics; Piperidines; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Receptors, Dopamine D5; Receptors, Serotonin	1996
Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3 Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Isoxazoles; Mass Spectrometry; Microsomes, Liver; Mixed Function Oxygenases; Piperidines	1998
Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:6 Topics: Animals; Antipsychotic Agents; Cattle; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Guinea Pigs; Humans; In Vitro Techniques; Isoxazoles; Male; Membranes; Piperidines; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Muscarinic; Receptors, Serotonin; Serotonin Receptor Agonists	2001
Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Progress in neuro-psychopharmacology & biological psychiatry, 2002, Volume: 26, Issue:3 Topics: 3T3 Cells; Animals; Antipsychotic Agents; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Humans; Isoxazoles; Male; Mice; Piperidines; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin	2002
Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain research, 2002, Nov-29, Volume: 956, Issue:2 Topics: Acetylcholine; Animals; Antipsychotic Agents; Butyrophenones; Clozapine; Dibenzothiazepines; Dopamine; Haloperidol; Isoxazoles; Male; Microdialysis; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1	2002
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs. European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine	2003
Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study. Neuroscience, 2003, Volume: 117, Issue:3 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Haloperidol; In Vitro Techniques; Isoxazoles; Magnesium; Male; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Time Factors	2003
Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors. Life sciences, 2003, Jul-18, Volume: 73, Issue:9 Topics: Animals; Antipsychotic Agents; Cell Line; Cricetinae; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Isoxazoles; Piperidines; Receptors, Biogenic Amine; Transfection	2003
Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm. Psychopharmacology, 2003, Volume: 169, Issue:3-4 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Choice Behavior; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Isoxazoles; Male; Memory, Short-Term; Muscarinic Antagonists; Nose; Piperidines; Rats; Reaction Time; Scopolamine; Time Factors	2003
Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology, 2006, Volume: 51, Issue:3 Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Gait Disorders, Neurologic; Imidazoles; Isoxazoles; Male; Neural Inhibition; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Reflex, Startle	2006
New advances in the treatment of schizophrenia. Introduction. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2 Suppl 1 Topics: Antipsychotic Agents; Humans; Isoxazoles; Piperidines; Schizophrenia	2008
Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2 Suppl 1 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Endpoint Determination; Female; Humans; Isoxazoles; Male; Middle Aged; Piperidines; Psychotic Disorders; Randomized Controlled Trials as Topic; Schizophrenia	2008
Iloperidone redux: a dissection of the Drug Approval Package for this newly commercialised second-generation antipsychotic. International journal of clinical practice, 2010, Volume: 64, Issue:6 Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Drug Approval; Humans; Isoxazoles; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Treatment Outcome; United States; United States Food and Drug Administration	2010
Iloperidone (Fanapt)--another second-generation antipsychotic. The Medical letter on drugs and therapeutics, 2010, Feb-22, Volume: 52, Issue:1332 Topics: Antipsychotic Agents; Humans; Isoxazoles; Piperidines; Schizophrenia	2010
Atypical antipsychotics: the two new arrivals. Issues in mental health nursing, 2011, Volume: 32, Issue:1 Topics: Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; Piperidines; Safety; Schizophrenia; Treatment Outcome; United States; United States Food and Drug Administration	2011
Iloperidone: Does it have a meaningful place in therapy? American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, Feb-15, Volume: 68, Issue:4 Topics: Antipsychotic Agents; Drug Administration Schedule; Drug Costs; Humans; Isoxazoles; Piperidines; Schizophrenia	2011
Update on newer antipsychotic drugs. Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:4 Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Pregnancy; Schizophrenia; Thiazoles; Treatment Outcome	2011
Biological perspectives: update on newer antipsychotic drugs: are they evidence based? Perspectives in psychiatric care, 2011, Volume: 47, Issue:4 Topics: Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Dibenzocycloheptenes; Evidence-Based Medicine; Heterocyclic Compounds, 4 or More Rings; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoindoles; Isoxazoles; Lactones; Lurasidone Hydrochloride; Piperidines; Psychotic Disorders; Pyridines; Serotonin Receptor Agonists; Sulfones; Thiazoles	2011
Scaffold hopping for identification of novel D(2) antagonist based on 3D pharmacophore modelling of illoperidone analogs. Molecular diversity, 2012, Volume: 16, Issue:2 Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Isoxazoles; Models, Molecular; Molecular Conformation; Piperidines; Quantitative Structure-Activity Relationship	2012
Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database. PLoS medicine, 2012, Volume: 9, Issue:3 Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Databases, Factual; Dibenzothiazepines; Humans; Isoxazoles; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Publication Bias; Pyrimidines; Quetiapine Fumarate; Quinolones; Risperidone; United States; United States Food and Drug Administration	2012
Iloperidone (Fanapt®), a novel atypical antipsychotic, is a potent HERG blocker and delays cardiac ventricular repolarization at clinically relevant concentration. Pharmacological research, 2012, Volume: 66, Issue:1 Topics: Action Potentials; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography, Ambulatory; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Conduction System; HEK293 Cells; Humans; Isoxazoles; Male; Patch-Clamp Techniques; Perfusion; Piperidines; Potassium Channel Blockers; Risk Assessment; Telemetry; Time Factors; Transfection	2012
Angioedema occurring in patient prescribed iloperidone and haloperidol: a cross-sensitivity reaction to antipsychotics from different chemical classes. The Journal of neuropsychiatry and clinical neurosciences, 2012,Spring, Volume: 24, Issue:2 Topics: Adult; Angioedema; Antipsychotic Agents; Drug Hypersensitivity; Haloperidol; Humans; Isoxazoles; Male; Piperidines	2012
Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine. PloS one, 2013, Volume: 8, Issue:1 Topics: Animals; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Dibenzocycloheptenes; Fasting; Female; Glucose Clamp Technique; Glucose Tolerance Test; Heterocyclic Compounds, 4 or More Rings; Hyperinsulinism; Insulin Resistance; Isoxazoles; Metabolism; Olanzapine; Piperidines; Rats; Rats, Sprague-Dawley	2013
Iloperidone-induced retrograde ejaculation. International clinical psychopharmacology, 2013, Volume: 28, Issue:3 Topics: Antipsychotic Agents; Capgras Syndrome; Ejaculation; Humans; Isoxazoles; Male; Piperidines; Schizophrenia; Sexual Dysfunctions, Psychological; Young Adult	2013
Stable-isotope dilution LC-MS/MS assay for determination of iloperidone and its two major metabolites, P 88 and P 95, in human plasma: application to a bioequivalence study. Bioanalysis, 2013, Volume: 5, Issue:6 Topics: Antipsychotic Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Deuterium; Half-Life; Humans; Isotope Labeling; Isoxazoles; Piperidines; Solid Phase Extraction; Tandem Mass Spectrometry; Therapeutic Equivalency	2013
Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Jun-01, Volume: 928 Topics: Antipsychotic Agents; Chromatography, Liquid; Dopamine D2 Receptor Antagonists; Humans; Isoxazoles; Liquid-Liquid Extraction; Male; Piperidines; Sensitivity and Specificity; Serotonin 5-HT2 Receptor Antagonists; Tandem Mass Spectrometry	2013
Complexities of personalized medicine: how genes, drug-drug interactions, dosing schedules, and other factors can combine to produce clinically meaningful differences in a drug's effect. Journal of psychiatric practice, 2013, Volume: 19, Issue:5 Topics: Affective Disorders, Psychotic; Aged; Antipsychotic Agents; Depressive Disorder, Major; Dizziness; Drug Interactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Isoxazoles; Male; Paroxetine; Pharmacogenetics; Piperidines; Precision Medicine	2013
Role of α1 adrenergic antagonism in the mechanism of action of iloperidone: reducing extrapyramidal symptoms. CNS spectrums, 2013, Volume: 18, Issue:6 Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Basal Ganglia Diseases; Corpus Striatum; Dopamine; Humans; Isoxazoles; Piperidines; Serotonin 5-HT2 Receptor Antagonists	2013
Quality by design approach to understand the process of optimization of iloperidone nanostructured lipid carriers for oral bioavailability enhancement. Pharmaceutical development and technology, 2015, Volume: 20, Issue:3 Topics: Administration, Oral; Animals; Antipsychotic Agents; Biological Availability; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Isoxazoles; Lipids; Male; Nanoparticles; Particle Size; Piperidines; Rats; Rats, Wistar; Solubility; Surface-Active Agents	2015
Psychotropic exposures in pediatric patients: Symptomatic iloperidone and vilazodone ingestions. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:3 Topics: Age Factors; Benzofurans; Child, Preschool; Female; Humans; Indoles; Infant; Isoxazoles; Male; Piperazines; Piperidines; Poisoning; Psychotropic Drugs; Risk Factors; Time Factors; Vilazodone Hydrochloride	2015
Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: application to iloperidone. Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:4 Topics: Antipsychotic Agents; Computer Simulation; Genotype; Humans; Isoxazoles; Models, Biological; Molecular Targeted Therapy; Neurobiology; Pharmacogenetics; Piperazines; Piperidines; Schizophrenia; Thiazoles	2015
Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. Neuropharmacology, 2016, Volume: 105 Topics: Adrenergic Uptake Inhibitors; Alcohol Drinking; Animals; Antipsychotic Agents; Clozapine; Cricetinae; Desipramine; Isoxazoles; Male; Mesocricetus; Piperidines	2016
Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone. Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Feb-24, Volume: 22, Issue:9 Topics: Antipsychotic Agents; Isoxazoles; Piperidines; Temperature; Water	2016
Asenapine, iloperidone and lurasidone exposures in young children reported to U.S. poison centers. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:5 Topics: Antipsychotic Agents; Child, Preschool; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Infant; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Poison Control Centers; Retrospective Studies; United States	2018
Supported liquid extraction and LC-MS-MS determination of iloperidone and olanzapine in rat plasma: Application to a pharmacokinetic study. Journal of chromatographic science, 2018, Nov-01, Volume: 56, Issue:10 Topics: Animals; Chromatography, Liquid; Isoxazoles; Limit of Detection; Linear Models; Male; Olanzapine; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry	2018
Novel Adverse Events of Iloperidone: A Disproportionality Analysis in US Food and Drug Administration Adverse Event Reporting System (FAERS) Database. Current drug safety, 2019, Volume: 14, Issue:1 Topics: Adverse Drug Reaction Reporting Systems; Akathisia, Drug-Induced; Antipsychotic Agents; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Isoxazoles; Piperidines; United States; United States Food and Drug Administration	2019
Transdermal lipid vesicular delivery of iloperidone: Formulation, in vitro and in vivo evaluation. Colloids and surfaces. B, Biointerfaces, 2019, Nov-01, Volume: 183 Topics: Acrylic Resins; Administration, Cutaneous; Animals; Antipsychotic Agents; Biological Availability; Cholesterol; Dermis; Drug Compounding; Ear; Ethylene Glycols; Gels; Isoxazoles; Liposomes; Particle Size; Permeability; Piperidines; Rats; Rats, Wistar; Skin Absorption; Swine	2019
Repurposing of Iloperidone: Antihypertensive and ocular hypotensive activity in animals. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Feb-15, Volume: 143 Topics: Animals; Antihypertensive Agents; Antipsychotic Agents; Blood Pressure; Desoxycorticosterone Acetate; Drug Repositioning; Female; Hypertension; Intraocular Pressure; Isoxazoles; Male; Molecular Docking Simulation; Piperidines; Rats, Wistar; Receptors, Adrenergic, alpha-1; Rotarod Performance Test	2020
Development, characterization, comparative pharmacokinetic and pharmacodynamic studies of iloperidone solid SMEDDS and liquisolid compact. Drug development and industrial pharmacy, 2020, Volume: 46, Issue:4 Topics: Administration, Oral; Animals; Antipsychotic Agents; Biological Availability; Chemistry, Pharmaceutical; Dizocilpine Maleate; Drug Carriers; Emulsions; Excipients; Humans; Isoxazoles; Locomotion; Male; Models, Animal; Particle Size; Piperidines; Rats; Schizophrenia; Solubility; Surface-Active Agents; Suspensions; Tablets	2020
The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions. Pharmacological reports : PR, 2020, Volume: 72, Issue:6 Topics: Animals; Antipsychotic Agents; Baculoviridae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Insecta; Isoxazoles; Lurasidone Hydrochloride; Microsomes, Liver; Piperidines	2020
Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy. Toxicology and applied pharmacology, 2020, 11-01, Volume: 406 Topics: Antipsychotic Agents; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dibenzocycloheptenes; Drug Interactions; Hepatocytes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoxazoles; L-Lactate Dehydrogenase; Lurasidone Hydrochloride; Piperidines; RNA, Messenger	2020
Pharmacokinetic and pharmacodynamic studies of iloperidone-loaded lipid nanoemulsions via oral route of administration. Drug development and industrial pharmacy, 2021, Volume: 47, Issue:4 Topics: Administration, Oral; Animals; Biological Availability; Isoxazoles; Lipids; Nanoparticles; Particle Size; Piperidines; Rats	2021
Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia. International journal of molecular sciences, 2021, May-24, Volume: 22, Issue:11 Topics: Animals; Animals, Newborn; Antipsychotic Agents; Cannabidiol; Cell Culture Techniques; Cerebral Cortex; Disease Models, Animal; Female; Isoxazoles; Male; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics	2021
The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms. International journal of molecular sciences, 2021, Aug-06, Volume: 22, Issue:16 Topics: Animals; Antipsychotic Agents; Cytochrome P-450 Enzyme System; Gene Expression; Isoxazoles; Liver; Male; Microsomes, Liver; Piperidines; Rats; Rats, Wistar; Schizophrenia	2021
Effects of iloperidone on hERG 1A/3.1 heterotetrameric channels. Neuroreport, 2021, 11-02, Volume: 32, Issue:16 Topics: Biotinylation; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Isoxazoles; Piperidines; Potassium Channel Blockers	2021
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7. Cell calcium, 2022, Volume: 106 Topics: Animals; Humans; Isoxazoles; Magnesium; Mice; Piperidines; Protein Serine-Threonine Kinases; Purine Nucleosides; Transient Receptor Potential Channels; TRPM Cation Channels	2022
Optimization and characterization of self-nanoemulsifying drug delivery system of iloperidone using box-behnken design and desirability function. Annales pharmaceutiques francaises, 2023, Volume: 81, Issue:1 Topics: Administration, Oral; Drug Delivery Systems; Emulsions; Isoxazoles; Nanoparticles; Particle Size; Solubility; Surface-Active Agents	2023

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