Page last updated: 2024-08-24

irinotecan and sn 38

irinotecan has been researched along with sn 38 in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.11)18.2507
2000's7 (38.89)29.6817
2010's7 (38.89)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL1
Akiyama, SI; Chen, ZS; Furukawa, T; Ono, K; Seto, K; Sumizawa, T; Ueda, K1
Beijnen, JH; de Jong, LA; Hausheer, FH; Maliepaard, M; Pluim, D; Schellens, JH; Tohgo, A; van Gastelen, MA; van Waardenburg, RC1
Akiyama, S; Baba, M; Furukawa, T; Nitanda, T; Okamoto, M; Sugimoto, Y; Wang, X1
Goto, A; Nakajima, M; Nezu, J; Nozawa, T; Sugiura, S; Tamai, I; Tsuji, A; Yokoi, T1
Minami, H; Nozawa, T; Sugiura, S; Tamai, I; Tsuji, A1
Chen, Y; Ding, J; Gao, H; Li, C; Lu, W; Pang, T; Shen, H; Sun, J; Xu, C; Zhang, X1
Dansette, PM; Fontana, E; Poli, SM1
Endo, M; Fukuda, H; Kawashima, A; Kobayashi, K; Kohchi, M; Miyazaki, Y; Morikami, K; Murasaki, C; Murata, T; Nakano, K; Nanba, E; Niizuma, S; Ogawa, K; Ohwada, J; Okabe, H; Ozawa, S; Shimma, N; Suda, H; Takasuka, T; Tanimura, H; Tsukazaki, M; Umeda, I; Ura, M; Yoshinari, K1
Akiyama, Y; Ando, Y; Fujita, K; Hirose, T; Ichikawa, W; Ishida, H; Kawara, K; Miwa, K; Miya, T; Mizuno, K; Nagashima, F; Narabayashi, M; Saji, S; Sasaki, Y; Sugiyama, M; Sunakawa, Y; Yamamoto, W; Yamashita, K1
Alloatti, D; Badaloni, E; Cabri, W; Castorina, M; Giannini, G; Pisano, C; Vesci, L1
Chang, LC; Goto, M; Hung, HY; Kuo, DH; Kuo, SC; Lee, KH; Liu, YQ; Morris-Natschke, SL; Nan, X; Pan, SL; Qian, K; Teng, CM; Wang, CY; Wang, MJ; Wu, TS; Wu, YC; Yang, JS; Yang, L; Yang, XM; Zhao, XB; Zhao, YL1
Chen, Y; Lu, W; Ma, L; Wang, L; Xie, S1
Benetti, E; Centamore, A; Collina, S; Della Volpe, S; Martino, E; Sakaj, M; Sala, A; Terribile, E1
Chen, Y; Li, J; Lu, W; Shen, Q; Su, M; Yu, X; Zhang, Q; Zhou, Y; Zhu, Q1
Fujimoto, M; Fukuda, T; Ishibashi, F; Iwao, M; Nanjo, Y; Natsui, Y; Okazaki, F; To, H; Yoshida, K1
Chen, Y; Fang, Y; Gao, Y; Lu, W; Shen, Q; Wang, L; Zhu, S1
Bednarek, E; Bocian, W; Górecki, M; Kozerski, L; Lubelska, K; Milczarek, M; Naumczuk, B; Sitkowski, J; Urbanowicz, M; Wiktorska, K1

Reviews

2 review(s) available for irinotecan and sn 38

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
The long story of camptothecin: From traditional medicine to drugs.
    Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptotheca; Camptothecin; DNA Topoisomerases, Type I; Humans; Medicine, Traditional; Neoplasms; Structure-Activity Relationship

2017

Trials

1 trial(s) available for irinotecan and sn 38

ArticleYear
Delayed elimination of SN-38 in cancer patients with severe renal failure.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Female; Genotype; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Prospective Studies; Renal Dialysis; Renal Insufficiency

2011

Other Studies

15 other study(ies) available for irinotecan and sn 38

ArticleYear
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous

1991
ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P.
    Molecular pharmacology, 1999, Volume: 55, Issue:5

    Topics: Adenosine Triphosphate; Anion Transport Proteins; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Biological Transport; Buthionine Sulfoximine; Camptothecin; Carrier Proteins; Cell Line; Cell Survival; Culture Media; Cyclic P-Oxides; DNA Topoisomerases, Type I; Drug Resistance, Multiple; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Irinotecan; Isoenzymes; KB Cells; Multidrug Resistance-Associated Proteins; Nicotinic Acids; Propionates; Quinolines

1999
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:4

    Topics: Acridines; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Survival; Drug Interactions; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Neoplasm Proteins; Tetrahydroisoquinolines; Tumor Cells, Cultured

2001
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.
    Molecular pharmacology, 2003, Volume: 63, Issue:1

    Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; CD4-Positive T-Lymphocytes; Cells, Cultured; Doxorubicin; Drug Resistance, Neoplasm; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Indoles; Lamivudine; Microbial Sensitivity Tests; Neoplasm Proteins; Reverse Transcriptase Inhibitors; Zidovudine

2003
Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:3

    Topics: Biological Transport, Active; Chemical and Drug Induced Liver Injury; Chromans; Cloning, Molecular; DNA, Complementary; Estrone; Hepatocytes; Humans; Hypoglycemic Agents; Molecular Sequence Data; Oocytes; Organic Anion Transporters; Pioglitazone; Protein Binding; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Troglitazone

2004
Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Cells, Cultured; Estrone; Female; Glucuronides; Humans; Irinotecan; Liver; Liver-Specific Organic Anion Transporter 1; Oocytes; Polymorphism, Single Nucleotide; Topoisomerase I Inhibitors; Xenopus

2005
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
    Bioorganic & medicinal chemistry letters, 2005, Jul-01, Volume: 15, Issue:13

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; Humans; Mice; Sarcoma 180; Structure-Activity Relationship; Topoisomerase I Inhibitors

2005
Synthesis of new camptothecin analogs with improved antitumor activities.
    Bioorganic & medicinal chemistry letters, 2009, Apr-01, Volume: 19, Issue:7

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; DNA Topoisomerases, Type I; Humans; Mice; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transplantation, Heterologous

2009
Camptothecins in tumor homing via an RGD sequence mimetic.
    Bioorganic & medicinal chemistry letters, 2012, Oct-15, Volume: 22, Issue:20

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Integrins; Male; Oligopeptides; Ovarian Neoplasms; Prostatic Neoplasms; Rats

2012
Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents.
    Journal of medicinal chemistry, 2014, Jul-24, Volume: 57, Issue:14

    Topics: Amidines; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; HCT116 Cells; Humans; KB Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Conformation; Neoplasms, Experimental; Structure-Activity Relationship; Sulfonamides; Topoisomerase I Inhibitors

2014
Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents.
    Bioorganic & medicinal chemistry, 2015, May-01, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; HT29 Cells; Humans; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2015
A series of camptothecin prodrugs exhibit HDAC inhibition activity.
    Bioorganic & medicinal chemistry, 2018, 09-01, Volume: 26, Issue:16

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Stability; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Isoenzymes; Mice; Prodrugs; Structure-Activity Relationship

2018
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
    Bioorganic & medicinal chemistry, 2019, 01-15, Volume: 27, Issue:2

    Topics: Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Coumarins; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Male; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors

2019
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation.
    Journal of medicinal chemistry, 2020, 05-28, Volume: 63, Issue:10

    Topics: A549 Cells; Animals; Antineoplastic Agents; Drug Delivery Systems; Drug Design; HCT116 Cells; HSP90 Heat-Shock Proteins; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays

2020
New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology.
    Bioorganic & medicinal chemistry letters, 2021, 08-15, Volume: 46

    Topics: Antineoplastic Agents; Camptothecin; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2021