irinotecan and sn 38
irinotecan has been researched along with sn 38 in 18 studies
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL | 1 |
| Akiyama, SI; Chen, ZS; Furukawa, T; Ono, K; Seto, K; Sumizawa, T; Ueda, K | 1 |
| Beijnen, JH; de Jong, LA; Hausheer, FH; Maliepaard, M; Pluim, D; Schellens, JH; Tohgo, A; van Gastelen, MA; van Waardenburg, RC | 1 |
| Akiyama, S; Baba, M; Furukawa, T; Nitanda, T; Okamoto, M; Sugimoto, Y; Wang, X | 1 |
| Goto, A; Nakajima, M; Nezu, J; Nozawa, T; Sugiura, S; Tamai, I; Tsuji, A; Yokoi, T | 1 |
| Minami, H; Nozawa, T; Sugiura, S; Tamai, I; Tsuji, A | 1 |
| Chen, Y; Ding, J; Gao, H; Li, C; Lu, W; Pang, T; Shen, H; Sun, J; Xu, C; Zhang, X | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Endo, M; Fukuda, H; Kawashima, A; Kobayashi, K; Kohchi, M; Miyazaki, Y; Morikami, K; Murasaki, C; Murata, T; Nakano, K; Nanba, E; Niizuma, S; Ogawa, K; Ohwada, J; Okabe, H; Ozawa, S; Shimma, N; Suda, H; Takasuka, T; Tanimura, H; Tsukazaki, M; Umeda, I; Ura, M; Yoshinari, K | 1 |
| Akiyama, Y; Ando, Y; Fujita, K; Hirose, T; Ichikawa, W; Ishida, H; Kawara, K; Miwa, K; Miya, T; Mizuno, K; Nagashima, F; Narabayashi, M; Saji, S; Sasaki, Y; Sugiyama, M; Sunakawa, Y; Yamamoto, W; Yamashita, K | 1 |
| Alloatti, D; Badaloni, E; Cabri, W; Castorina, M; Giannini, G; Pisano, C; Vesci, L | 1 |
| Chang, LC; Goto, M; Hung, HY; Kuo, DH; Kuo, SC; Lee, KH; Liu, YQ; Morris-Natschke, SL; Nan, X; Pan, SL; Qian, K; Teng, CM; Wang, CY; Wang, MJ; Wu, TS; Wu, YC; Yang, JS; Yang, L; Yang, XM; Zhao, XB; Zhao, YL | 1 |
| Chen, Y; Lu, W; Ma, L; Wang, L; Xie, S | 1 |
| Benetti, E; Centamore, A; Collina, S; Della Volpe, S; Martino, E; Sakaj, M; Sala, A; Terribile, E | 1 |
| Chen, Y; Li, J; Lu, W; Shen, Q; Su, M; Yu, X; Zhang, Q; Zhou, Y; Zhu, Q | 1 |
| Fujimoto, M; Fukuda, T; Ishibashi, F; Iwao, M; Nanjo, Y; Natsui, Y; Okazaki, F; To, H; Yoshida, K | 1 |
| Chen, Y; Fang, Y; Gao, Y; Lu, W; Shen, Q; Wang, L; Zhu, S | 1 |
| Bednarek, E; Bocian, W; Górecki, M; Kozerski, L; Lubelska, K; Milczarek, M; Naumczuk, B; Sitkowski, J; Urbanowicz, M; Wiktorska, K | 1 |
Reviews
2 review(s) available for irinotecan and sn 38
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
The long story of camptothecin: From traditional medicine to drugs.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptotheca; Camptothecin; DNA Topoisomerases, Type I; Humans; Medicine, Traditional; Neoplasms; Structure-Activity Relationship | 2017 |
Trials
1 trial(s) available for irinotecan and sn 38
| Article | Year |
|---|---|
Delayed elimination of SN-38 in cancer patients with severe renal failure.
Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Female; Genotype; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Prospective Studies; Renal Dialysis; Renal Insufficiency | 2011 |
Other Studies
15 other study(ies) available for irinotecan and sn 38
| Article | Year |
|---|---|
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous | 1991 |
ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P.
Topics: Adenosine Triphosphate; Anion Transport Proteins; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Biological Transport; Buthionine Sulfoximine; Camptothecin; Carrier Proteins; Cell Line; Cell Survival; Culture Media; Cyclic P-Oxides; DNA Topoisomerases, Type I; Drug Resistance, Multiple; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Irinotecan; Isoenzymes; KB Cells; Multidrug Resistance-Associated Proteins; Nicotinic Acids; Propionates; Quinolines | 1999 |
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Topics: Acridines; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Survival; Drug Interactions; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Neoplasm Proteins; Tetrahydroisoquinolines; Tumor Cells, Cultured | 2001 |
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; CD4-Positive T-Lymphocytes; Cells, Cultured; Doxorubicin; Drug Resistance, Neoplasm; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Indoles; Lamivudine; Microbial Sensitivity Tests; Neoplasm Proteins; Reverse Transcriptase Inhibitors; Zidovudine | 2003 |
Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.
Topics: Biological Transport, Active; Chemical and Drug Induced Liver Injury; Chromans; Cloning, Molecular; DNA, Complementary; Estrone; Hepatocytes; Humans; Hypoglycemic Agents; Molecular Sequence Data; Oocytes; Organic Anion Transporters; Pioglitazone; Protein Binding; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Troglitazone | 2004 |
Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Cells, Cultured; Estrone; Female; Glucuronides; Humans; Irinotecan; Liver; Liver-Specific Organic Anion Transporter 1; Oocytes; Polymorphism, Single Nucleotide; Topoisomerase I Inhibitors; Xenopus | 2005 |
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; Humans; Mice; Sarcoma 180; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2005 |
Synthesis of new camptothecin analogs with improved antitumor activities.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; DNA Topoisomerases, Type I; Humans; Mice; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transplantation, Heterologous | 2009 |
Camptothecins in tumor homing via an RGD sequence mimetic.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Integrins; Male; Oligopeptides; Ovarian Neoplasms; Prostatic Neoplasms; Rats | 2012 |
Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents.
Topics: Amidines; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; HCT116 Cells; Humans; KB Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Conformation; Neoplasms, Experimental; Structure-Activity Relationship; Sulfonamides; Topoisomerase I Inhibitors | 2014 |
Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; HT29 Cells; Humans; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2015 |
A series of camptothecin prodrugs exhibit HDAC inhibition activity.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Stability; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Isoenzymes; Mice; Prodrugs; Structure-Activity Relationship | 2018 |
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Coumarins; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Male; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2019 |
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation.
Topics: A549 Cells; Animals; Antineoplastic Agents; Drug Delivery Systems; Drug Design; HCT116 Cells; HSP90 Heat-Shock Proteins; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays | 2020 |
New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology.
Topics: Antineoplastic Agents; Camptothecin; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2021 |