inositol and sorbinil

inositol has been researched along with sorbinil in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (57.69)	18.7374
1990's	30 (38.46)	18.2507
2000's	3 (3.85)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Luheshi, GN; Zar, MA	1
Cammarata, PR; Chen, HQ; Yang, J; Yorio, T	2
Cammarata, PR; Tse, D; Yorio, T	2
Andaloro, VJ; Crews, FT; Guzman, NJ; Kurian, P; Tisher, CC	1
Engerman, RL; Kern, TS	1
Flam, BR; Sawicki, DR; Sredy, J	1
Wasada, T	1
Coleman, BD; Plurad, SB; Schmidt, RE; Tilton, RG; Williamson, JR	1
Futterweit, S; Hammer, E; Oates, P; Siegel, TW; Trachtman, H	1
Giblin, FJ; Kador, PF; Kinoshita, JH; Lin, LR; Reddy, VN	1
Brennan, MC; Del Monte, MA; Diaz, TC; Greene, DA; Lattimer, SA; Nakamura, J; Rabbani, R	1
Goldfarb, S; Kern, EF; Simmons, DA; Ziyadeh, FN	1
Arimura, T; Ebata, K; Haneda, M; Horide, N; Kikkawa, R; Maeda, S; Sawada, T; Shigeta, Y; Togawa, M	1
Gerbitz, KD; Olgemöller, B; Schleicher, ED; Schwaabe, S	1
Cook, WR; Lowitt, S; Malone, JI	1
Cohen, RA; Epstein, FH; MacGregor, LC; Silva, P; Spokes, KC	1
Carroll, PB; Fernstrom, JD; Finegold, DN; Greene, DA; Lattimer, SA	1
Brenner, RM; Gullans, SR; Heilig, CW; Kone, BC; Yu, AS	1
Greene, DA	1
Robinson, JP; Tomlinson, DR; Willars, GB	1
Calthrop-Owen, EF; Tomlinson, DR; Willars, GB	1
Calcutt, NA; Clarke, HE; Compton, AM; Keen, P; Macdonald, IA; Tomlinson, DR; Willars, GB	1
Calcutt, NA; Compton, AM; Keen, P; Tomlinson, DR; Willars, GB	1
Dunlap, JA; Yorek, MA	1
Plurad, SB; Schmidt, RE; Sherman, WR; Tilton, RG; Williamson, JR	1
Dunlap, JA; Leeney, EM; Yorek, MA	1
Simmons, DA; Winegrad, AI	1
Li, WY	1
Ashton, MA; Beyer, TA; Goddu, KJ; Hutson, NJ; Rafford, CE; Yeh, LA	1
Fujimori, S; Hirata, Y; Okada, K	1
Dunlap, JA; Ginsberg, BH; Yorek, MA	2
Hawthorne, JN; Simpson, CM	1
Mayer, JH; Tomlinson, DR	1
Cohen, MP; Dasmahapatra, A; Shapiro, E	1
Greene, DA; Lattimer, SA	2
MacGregor, LC; Matschinsky, FM	2
Greene, DA; Mackway, AM	1
Carroll, PB; Greene, DA; Thornton, BM	1
Cheng, HM; Kawaba, T; Kinoshita, JH	1
Cohen, M	1
Cameron, NE; Leonard, MB; Ross, IS; Whiting, PH	1
Chan, LS; Khatami, M; Li, W; Rockey, JH	1
Goldfarb, S; Kern, EF; Simmons, DA	1
Dyck, PJ; Karnes, JL; Minnerath, SR; Poduslo, JF; Vilen, TH; Yao, JK; Zimmerman, BR	1
Khatami, M; Rockey, JH	1
Ross, IS; Whiting, PH	1
Dunlop, ME; Hill, MA; Larkins, RG	1
Gregersen, G	1
Beyer-Mears, A; Cruz, E	1
Burgess, SE; Cheng, H; Crabbe, MJ; Petchey, M	1
Clements, RS	1
Ackermann, KE; Chang, K; Kilo, C; Marvel, J; Rowold, E; Sherman, WR; Tomlinson, M; Williamson, JR	2
Mayer, JH; Moriarty, RJ; Tomlinson, DR	1
Bernstein, M; Finegold, D; Greene, DA; Lattimer, SA; Nolle, S	1
Gillon, KR; Hawthorne, JN; Tomlinson, DR	1
Beyer-Mears, A; Cohen, MP; Ku, L	1
Handelsman, DJ; Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK	1
Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA	1
Gillon, KR; Hawthorne, JN	1
Albrecht, BN; Florkiewicz, RZ; Lowe, WL; Spanheimer, RG; Yorek, MA	1
Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG	1
Cammarata, PR; Chen, HQ	1
Greene, DA; Henry, DN; Killen, PD; Stevens, MJ; Thomas, TP	1
Greene, DA; Kamijo, M; Lattimer, SA; Sima, AA; Stevens, MJ; Van Huysen, C	1
Conner, CE; Davidson, EP; Dunlap, JA; Greene, DA; Kamijo, M; Lattimer, SA; Sima, AA; Stefani, MR; Wiese, TJ; Yorek, MA	1
Berti-Mattera, L; Day, N; Eichberg, J; Peterson, RG	1
Lowe, WL; Matsushita, K; Stokes, JB; Wiese, TJ; Yorek, MA	1
Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K	1
Chopra, JS; Joshi, K; Karihaloo, AK	1
Fathallah, L; Obrosova, IG	1
Coppey, LJ; Davidson, EP; Dunlap, JA; Gellett, JS; Yorek, MA	1
Ziegler, D	1

Reviews

2 review(s) available for inositol and sorbinil

Article	Year
Somatic neurophysiology in diabetes. Basic observations and the effect of treatment. Clinical physiology (Oxford, England), 1985, Volume: 5 Suppl 5 Topics: Adolescent; Adult; Aged; Animals; Calcium; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Inositol; Insulin; Ischemia; Middle Aged; Neural Conduction; Perception; Peripheral Nerves; Potassium; Vibration	1985
Review of myo-inositol and sorbinil studies. Clinical physiology (Oxford, England), 1985, Volume: 5 Suppl 5 Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetic Neuropathies; Diet; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Inositol; Middle Aged; Neural Conduction; Peripheral Nerves; Polymers; Random Allocation	1985

Trials

3 trial(s) available for inositol and sorbinil

Article	Year
The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction. Experimental eye research, 1985, Volume: 40, Issue:1 Topics: Aged; Aldehyde Reductase; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; Diabetes Mellitus; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Review of myo-inositol and sorbinil studies. Clinical physiology (Oxford, England), 1985, Volume: 5 Suppl 5 Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetic Neuropathies; Diet; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Inositol; Middle Aged; Neural Conduction; Peripheral Nerves; Polymers; Random Allocation	1985
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment. Diabetologia, 1984, Volume: 27, Issue:5 Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Female; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases	1984

Other Studies

74 other study(ies) available for inositol and sorbinil

Article	Year
Effect of streptozotocin diabetes on motor and inhibitory transmission in rat anococcygeus. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:10 Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electric Stimulation; Guanethidine; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Male; Muscle Contraction; Muscle, Smooth; Neural Inhibition; Norepinephrine; Rats; Rats, Wistar; Synaptic Transmission	1992
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. I. Restoration of myo-inositol uptake by aldose reductase inhibition. Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:13 Topics: Aldehyde Reductase; Animals; Biological Transport; Cattle; Cells, Cultured; Deoxyglucose; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Meglumine; Sodium; Sorbitol	1992
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. II. Characterization of high- and low-affinity myo-inositol transport sites. Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:13 Topics: Aldehyde Reductase; Animals; Binding Sites; Biological Transport; Cattle; Cells, Cultured; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Sorbitol	1992
Uncoupling of attenuated myo-[3H]inositol uptake and dysfunction in Na(+)-K(+)-ATPase pumping activity in hypergalactosemic cultured bovine lens epithelial cells. Diabetes, 1991, Volume: 40, Issue:6 Topics: Aldehyde Reductase; Animals; Biological Transport, Active; Cattle; Diabetic Retinopathy; Epithelium; Galactose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Kinetics; Lens, Crystalline; Models, Biological; Rubidium; Sodium-Potassium-Exchanging ATPase; Tritium	1991
Effects of glucose on receptor-mediated phosphoinositide hydrolysis and second messenger generation in rat glomerular mesangial cells. Journal of the American Society of Nephrology : JASN, 1991, Volume: 2, Issue:2 Topics: Animals; Diglycerides; Enzyme Activation; Glomerular Mesangium; Glucose; Hydrolysis; Imidazoles; Imidazolidines; Inositol; Phosphatidylinositols; Phospholipids; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Second Messenger Systems	1991
Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor. Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:13 Topics: Aldehyde Reductase; Alloxan; Animals; Chromatography, Gas; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Erythrocytes; Galactitol; Galactosemias; Imidazoles; Imidazolidines; Inositol; Muscles; Retina	1991
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 197, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sucrose	1991
[Diabetic neuropathy--pathogenesis and precipitating factors]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Alcohol Drinking; Animals; Diabetic Neuropathies; Energy Metabolism; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Risk Factors; Smoking; Sodium-Potassium-Exchanging ATPase; Sorbitol	1991
Effects of sorbinil, dietary myo-inositol supplementation, and insulin on resolution of neuroaxonal dystrophy in mesenteric nerves of streptozocin-induced diabetic rats. Diabetes, 1991, Volume: 40, Issue:5 Topics: Aldehyde Reductase; Animals; Autonomic Nervous System; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Imidazoles; Imidazolidines; Inositol; Insulin; Male; Mesentery; Rats; Rats, Inbred Strains; Reference Values	1991
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states. Life sciences, 1991, Volume: 49, Issue:9 Topics: Aldehyde Reductase; Analysis of Variance; Animals; Brain; Electrolytes; Hypernatremia; Hyponatremia; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Vasopressins; Water-Electrolyte Balance	1991
Polyol accumulation in cultured human lens epithelial cells. Experimental eye research, 1991, Volume: 52, Issue:1 Topics: Aldehyde Reductase; Cells, Cultured; Epithelial Cells; Epithelium; Fluorenes; Galactitol; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Microscopy, Electron; Microscopy, Phase-Contrast; Polymers; Reference Values; Stereoisomerism; Vacuoles	1991
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications. Diabetes, 1991, Volume: 40, Issue:10 Topics: Adult; Aldehyde Reductase; Cells, Cultured; Diabetic Retinopathy; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Middle Aged; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Sorbitol	1991
Effects of polyol-pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats. Diabetes, 1991, Volume: 40, Issue:4 Topics: Animals; Blood Glucose; Blood Pressure; Captopril; Diabetes Mellitus, Experimental; Diet; Dietary Proteins; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Male; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Sugar Alcohols	1991
Glucose inhibits myo-inositol uptake and reduces myo-inositol content in cultured rat glomerular mesangial cells. Metabolism: clinical and experimental, 1990, Volume: 39, Issue:1 Topics: Aldehyde Reductase; Animals; Cells, Cultured; Culture Media; Cytochalasin B; Dose-Response Relationship, Drug; Glomerular Mesangium; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Ouabain; Rats; Rats, Inbred Strains; Sodium	1990
Competitive inhibition by glucose of myo-inositol incorporation into cultured porcine aortic endothelial cells. Biochimica et biophysica acta, 1990, Apr-09, Volume: 1052, Issue:1 Topics: Aldehyde Reductase; Animals; Aorta, Thoracic; Biological Transport; Cells, Cultured; Cytochalasin B; Endothelium, Vascular; Glucose; Hexoses; Imidazoles; Imidazolidines; Inositol; Insulin; Kinetics; Ouabain; Sodium; Swine	1990
Nonosmotic diabetic cataracts. Pediatric research, 1990, Volume: 27, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Taurine	1990
Sorbinil prevents the hypergalactosemic-induced reduction in [3H]-myo-inositol uptake and decreased [3H]-myo-inositol incorporation into the phosphoinositide cycle in bovine lens epithelial cells in vitro. Current eye research, 1990, Volume: 9, Issue:6 Topics: Aldehyde Reductase; Animals; Cattle; Cells, Cultured; Chromatography, Ion Exchange; Epithelium; Galactitol; Galactose; Imidazoles; Imidazolidines; Inositol; Inositol Phosphates; Lens, Crystalline; Phosphatidylinositols; Phospholipids; Sugar Alcohol Dehydrogenases	1990
Effect of myo-inositol on renal Na-K-ATPase in experimental diabetes. Metabolism: clinical and experimental, 1990, Volume: 39, Issue:10 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Inositol; Kidney; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase	1990
A defect in sodium-dependent amino acid uptake in diabetic rabbit peripheral nerve. Correction by an aldose reductase inhibitor or myo-inositol administration. The Journal of clinical investigation, 1990, Volume: 85, Issue:5 Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Insulin; Kinetics; Male; Ouabain; Rabbits; Reference Values; Sodium; Tibial Nerve	1990
Modulation of osmolytes in MDCK cells by solutes, inhibitors, and vasopressin. The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 2 Topics: Animals; Cell Line; Glucose; Glycerylphosphorylcholine; Imidazoles; Imidazolidines; Inositol; Kidney; Phlorhizin; Sodium Chloride; Sorbitol; Vasopressins; Water-Electrolyte Balance	1990
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazoles; Imidazolidines; Inositol; Ion Channels; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred BB; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol	1986
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Phospholipids; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1986
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway. Experimental neurology, 1987, Volume: 96, Issue:1 Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Peripheral Nerves; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Sorbitol	1987
Effects of sorbinil treatment in rats with chronic streptozotocin-diabetes; changes in lens and in substance P and catecholamines in the iris. Current eye research, 1989, Volume: 8, Issue:4 Topics: Animals; Blood Glucose; Body Weight; Catecholamines; Diabetes Mellitus, Experimental; Epinephrine; Imidazoles; Imidazolidines; Inositol; Iris; Lens, Crystalline; Male; Norepinephrine; Rats; Rats, Inbred Strains; Sciatic Nerve; Substance P; Time Factors; Trigeminal Ganglion	1989
Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tract of rats with long-term diabetes mellitus. Effects of aldose reductase inhibition. Journal of the neurological sciences, 1989, Volume: 91, Issue:1-2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Digestive System; Heart Atria; Imidazoles; Imidazolidines; Inositol; Male; Myocardium; Peripheral Nerves; Rats; Rats, Inbred Strains; Skin; Streptozocin; Substance P; Time Factors	1989
The effect of elevated glucose levels on myo-inositol metabolism in cultured bovine aortic endothelial cells. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:1 Topics: Aldehyde Reductase; Animals; Aorta; Cattle; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Phospholipids; Sorbitol	1989
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats. Diabetes, 1989, Volume: 38, Issue:5 Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactose; Ganglia, Sympathetic; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases	1989
Effect of galactose and glucose levels and sorbinil treatment on myo-inositol metabolism and Na+-K+ pump activity in cultured neuroblastoma cells. Diabetes, 1989, Volume: 38, Issue:8 Topics: Aldehyde Reductase; Animals; Cell Line; Galactose; Glucose; Imidazoles; Imidazolidines; Inositol; Mice; Neuroblastoma; Phosphatidylinositols; Polymers; Potassium Channels; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured	1989
Mechanism of glucose-induced (Na+, K+)-ATPase inhibition in aortic wall of rabbits. Diabetologia, 1989, Volume: 32, Issue:7 Topics: Aldehyde Reductase; Animals; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Rabbits; Sodium-Potassium-Exchanging ATPase	1989
[Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1989, Volume: 11, Issue:6 Topics: Aldehyde Reductase; Animals; Cattle; Cell Line; Diabetic Retinopathy; Glucose; Imidazoles; Imidazolidines; Inositol; Phosphatidylinositols; Sorbitol	1989
Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats. Diabetes, 1987, Volume: 36, Issue:12 Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glutathione; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Male; Ouabain; Rats; Rats, Inbred Strains; Rubidium; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1987
Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats. Metabolism: clinical and experimental, 1988, Volume: 37, Issue:2 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1988
Effect of increased glucose levels on Na+/K+-pump activity in cultured neuroblastoma cells. Journal of neurochemistry, 1988, Volume: 51, Issue:2 Topics: Aldehyde Reductase; Animals; Cell Line; Glucose; Imidazoles; Imidazolidines; Inositol; Mice; Neuroblastoma; Rubidium; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured	1988
Reduced Na+ + K+-ATPase activity in peripheral nerve of streptozotocin-diabetic rats: a role for protein kinase C? Diabetologia, 1988, Volume: 31, Issue:5 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Reference Values; Rubidium; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase	1988
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Motor Neurons; Neural Conduction; Rats; Sorbitol	1985
Reduced glomerular sodium/potassium adenosine triphosphatase activity in acute streptozocin diabetes and its prevention by oral sorbinil. Diabetes, 1985, Volume: 34, Issue:11 Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Male; Ouabain; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase	1985
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor. The American journal of medicine, 1985, Nov-15, Volume: 79, Issue:5A Topics: Aldehyde Reductase; Animals; Biological Transport; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Inositol; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidazoles; Imidazolidines; Inositol; Pigment Epithelium of Eye; Rabbits; Rats; Retina; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol	1986
Decreased myo-inositol content and Na+-K+-ATPase activity in superior cervical ganglion of STZ-diabetic rat and prevention by aldose reductase inhibition. Diabetes, 1986, Volume: 35, Issue:10 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Ganglia, Sympathetic; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sugar Alcohol Dehydrogenases	1986
Glutathione redox state is not the link between polyol pathway activity and myo-inositol-related Na+-K+-ATPase defect in experimental diabetic neuropathy. Diabetes, 1986, Volume: 35, Issue:11 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glutathione; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sugar Alcohol Dehydrogenases	1986
The accumulation of myoinositol and rubidium ions in galactose-exposed rat lens. Investigative ophthalmology & visual science, 1986, Volume: 27, Issue:10 Topics: Aldehyde Reductase; Animals; Cataract; Galactose; Hypertonic Solutions; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Radioisotopes; Rats; Rubidium; Sodium-Potassium-Exchanging ATPase	1986
Aldose reductase inhibition, glomerular metabolism, and diabetic nephropathy. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1985
The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat. Diabetologia, 1986, Volume: 29, Issue:3 Topics: Age Factors; Aldehyde Reductase; Animals; Axons; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Neural Conduction; Peripheral Nerves; Polymers; Rats; Rats, Inbred Strains; Sciatic Nerve; Sugar Alcohol Dehydrogenases	1986
Non-competitive inhibition of myo-inositol transport in cultured bovine retinal capillary pericytes by glucose and reversal by Sorbinil. Biochimica et biophysica acta, 1986, May-28, Volume: 857, Issue:2 Topics: 3-O-Methylglucose; Adenosine Triphosphate; Aldehyde Reductase; Animals; Biological Transport, Active; Calcium; Capillaries; Cattle; Cells, Cultured; Deoxyglucose; Galactose; Glucose; Hexoses; Imidazoles; Imidazolidines; Inositol; Kinetics; Manganese; Methylglucosides; Retina	1986
Amelioration of glomerular hyperfiltration in acute experimental diabetes mellitus by dietary myo-inositol supplementation and aldose reductase inhibition. Transactions of the Association of American Physicians, 1986, Volume: 99 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases	1986
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy. The New England journal of medicine, 1988, Sep-01, Volume: 319, Issue:9 Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Myelin Sheath; Nerve Regeneration; Nerve Tissue; Sorbitol; Sural Nerve	1988
Regulation of uptake of inositol by glucose in cultured retinal pigment epithelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, Volume: 66, Issue:9 Topics: Aldehyde Reductase; Animals; Carbohydrates; Cattle; Cell Count; Cell Survival; Cells, Cultured; Culture Media; DNA; Extracellular Space; Glucose; Imidazoles; Imidazolidines; Inositol; Lactates; Phlorhizin; Pigment Epithelium of Eye; Pyruvates	1988
Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil. British journal of experimental pathology, 1988, Volume: 69, Issue:5 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Time Factors	1988
The influence of insulin and sorbinil on myoinositol uptake in peripheral nerve from normal and diabetic rats and a neuroblastoma cell line (N1E-115). Diabetes research (Edinburgh, Scotland), 1988, Volume: 8, Issue:2 Topics: Aldehyde Reductase; Animals; Cell Line; Diabetes Mellitus, Experimental; Femoral Nerve; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Insulin; Kinetics; Male; Neuroblastoma; Phloretin; Rats; Rats, Inbred Strains; Reference Values	1988
Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels. Journal of neurochemistry, 1988, Volume: 51, Issue:2 Topics: Animals; Cell Line; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Mice; Neuroblastoma; Sorbitol; Tumor Cells, Cultured	1988
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes, 1985, Volume: 34, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats. The Journal of clinical investigation, 1985, Volume: 76, Issue:2 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Imidazoles; Imidazolidines; Inositol; Male; Pigment Epithelium of Eye; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Adolescent; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Granulation Tissue; Humans; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Stereoisomerism	1986
Sorbinil prevents diabetes-induced increases in vascular permeability but does not alter collagen cross-linking. Diabetes, 1985, Volume: 34, Issue:7 Topics: Albumins; Animals; Blood Glucose; Capillary Permeability; Collagen; Diabetes Mellitus, Experimental; Humans; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains	1985
Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity. Diabetes, 1984, Volume: 33, Issue:8 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Ouabain; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase	1984
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. Diabetes, 1984, Volume: 33, Issue:5 Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1984
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy. Diabetes, 1983, Volume: 32, Issue:11 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohols	1983
Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition. Diabetologia, 1983, Volume: 25, Issue:4 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1983
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil. Diabetes, 1984, Volume: 33, Issue:6 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Male; Proteins; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1984
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats. Metabolism: clinical and experimental, 1984, Volume: 33, Issue:12 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; Imidazoles; Imidazolidines; Inositol; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1984
Sorbitol, inositol and nerve conduction in diabetes. Life sciences, 1983, Apr-25, Volume: 32, Issue:17 Topics: Animals; Diabetes Mellitus; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Mice; Mice, Inbred C57BL; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1983
Regulation of growth factor mRNA levels in the eyes of diabetic rats. Metabolism: clinical and experimental, 1995, Volume: 44, Issue:8 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retinopathy; Eye; Fibroblast Growth Factor 2; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Insulin-Like Growth Factor I; Kidney; Lens, Crystalline; Lung; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Streptozocin	1995
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes, 1993, Volume: 42, Issue:2 Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea	1993
Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 1: A hypertonicity-induced protein enhances myo-inositol transport. Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:3 Topics: Aldehyde Reductase; Animals; Biological Transport; Carrier Proteins; Cattle; Cells, Cultured; Cycloheximide; Epithelium; Galactitol; Galactose; Heat-Shock Proteins; Hypertonic Solutions; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Membrane Proteins; Symporters; Water-Electrolyte Balance	1994
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells. The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1 Topics: Aldehyde Reductase; Blood Glucose; Cell Line; Fructose; Gene Expression; Glucose; Humans; Hyperglycemia; Imidazoles; Imidazolidines; Inositol; Mannitol; Osmolar Concentration; Osmosis; Pigment Epithelium of Eye; Sorbitol; Time Factors; Water-Electrolyte Balance	1993
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat. Diabetologia, 1993, Volume: 36, Issue:7 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Osmolar Concentration; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Taurine	1993
Reduced motor nerve conduction velocity and Na(+)-K(+)-ATPase activity in rats maintained on L-fucose diet. Reversal by myo-inositol supplementation. Diabetes, 1993, Volume: 42, Issue:10 Topics: Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dietary Carbohydrates; Dose-Response Relationship, Drug; Fucose; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Ouabain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Streptozocin; Time Factors	1993
An aldose reductase inhibitor but not myo-inositol blocks enhanced polyphosphoinositide turnover in peripheral nerve from diabetic rats. Metabolism: clinical and experimental, 1996, Volume: 45, Issue:3 Topics: Aldehyde Reductase; Animals; Blood Glucose; Carbohydrates; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Imidazoles; Imidazolidines; Inositol; Male; Peripheral Nerves; Phosphatidylinositol Phosphates; Rats; Rats, Sprague-Dawley; Streptozocin	1996
Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats. Kidney international, 1996, Volume: 50, Issue:4 Topics: 3-O-Methylglucose; Aldehyde Reductase; Animals; Base Sequence; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Heat-Shock Proteins; Hypoglycemic Agents; Imidazoles; Imidazolidines; In Situ Hybridization; Inositol; Insulin, Isophane; Kidney Cortex; Kidney Medulla; Loop of Henle; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Symporters; Time Factors	1996
Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx. Pharmacology, 1997, Volume: 54, Issue:2 Topics: Aldehyde Reductase; Animals; Benzothiazoles; Carbohydrate Metabolism; Carbohydrates; Culture Media; Enzyme Inhibitors; Galactose; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Lens, Crystalline; Male; Phthalazines; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol; Thiazoles	1997
Effect of sorbinil and ascorbic acid on myo-inositol transport in cultured rat Schwann cells exposed to elevated extracellular glucose. Journal of neurochemistry, 1997, Volume: 69, Issue:5 Topics: Aldehyde Reductase; Animals; Animals, Newborn; Ascorbic Acid; Biological Transport; Cells, Cultured; Enzyme Inhibitors; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Phospholipids; Rats; Rats, Wistar; Schwann Cells; Sciatic Nerve	1997
Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study. Diabetologia, 2000, Volume: 43, Issue:8 Topics: Adenine Nucleotides; Adenosine Triphosphatases; Aldehyde Reductase; Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; NAD; NADP; Proton-Translocating ATPases; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sorbitol	2000
Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. International journal of experimental diabetes research, 2002, Volume: 3, Issue:1 Topics: Aldehyde Reductase; Animals; Arginine; Arterioles; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Imidazoles; Imidazolidines; Inositol; Lysine; Male; Neural Conduction; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Superoxides	2002
Treatment of diabetic neuropathy and neuropathic pain: how far have we come? Diabetes care, 2008, Volume: 31 Suppl 2 Topics: Aldehyde Reductase; Analgesics, Opioid; Clinical Trials as Topic; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazolidines; Incidence; Inositol; Polyneuropathies; Sodium Channel Blockers; Sodium-Potassium-Exchanging ATPase	2008