inositol has been researched along with lithium in 225 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 80 (35.56) | 18.7374 |
| 1990's | 100 (44.44) | 18.2507 |
| 2000's | 33 (14.67) | 29.6817 |
| 2010's | 8 (3.56) | 24.3611 |
| 2020's | 4 (1.78) | 2.80 |
| Authors | Studies |
|---|---|
| Allison, JH; Blisner, ME; Hipps, PP; Holland, WH; Sherman, WR | 1 |
| Allison, JH; Blisner, ME | 1 |
| Bloch-Faure, M; Chabardès, D; Guillon, G; Meneton, P; Morel, F; Rajerison, RM | 1 |
| Iriuchijima, T; Michimata, T; Mizuma, H; Mori, M; Murakami, M; Ogiwara, T; Yamada, M | 1 |
| Anderson, K; Woodcock, EA | 1 |
| Challiss, RA; Jenkinson, S; Nahorski, SR | 1 |
| DasGupta, K; Weiler, MH | 1 |
| Belyavskyi, M; Sauer, HW | 1 |
| Collins, M; Klug, S; Merker, HJ; Nagao, T; Neubert, D | 1 |
| Dixon, JF; Hokin, LE; Lee, CH; Los, GV | 1 |
| Belmaker, RH; Bersudskey, Y; Kofman, O; Revazov, A | 1 |
| Rehn, M; Tayag, A; Tio, D; Warburton, D | 1 |
| Gobran, LI; Griese, M; Rooney, SA | 1 |
| Buxton, IL; Doggwiler, KO; Schiemann, WP | 1 |
| Freinkel, N; Lewis, NJ; Tanigawa, K | 1 |
| Jackson, A; Oles, RJ; Singh, L; Tricklebank, MD | 1 |
| Bognár, R; Kiss, A; Koncz, C; Pelyvás, I; Schablik, M; Szabó, G; Sztaricskai, F | 1 |
| Hirvonen, MR | 1 |
| Challiss, RA; Nahorski, SR; Ragan, CI | 1 |
| Adelson, JR; Monaco, ME | 1 |
| Hirvonen, MR; Savolainen, K | 1 |
| Lin, TN; Navidi, M; Sun, GY; Yoa, FG | 1 |
| Morin, D; Querol-Ferrer, V; Sapena, R; Tillement, JP; Zini, R | 1 |
| Alpert, C; Belmaker, RH; Fuchs, I; Grisaru, N; Katz, V; Kofman, O; Rigler, O | 1 |
| Aronson, JK; Brearley, CJ; Jenkins, RJ | 1 |
| Belmaker, RH; Kofman, O | 3 |
| Crawford, ML; Young, JM | 2 |
| Fu, DX; Zhu, PH | 2 |
| Kato, R; Nakaki, T; Sasakawa, N | 1 |
| Cubitt, AB; Geras-Raaka, E; Gershengorn, MC | 1 |
| Desrues, L; Tonon, MC; Vaudry, H | 1 |
| Sanborn, BB; Schneider, AS | 1 |
| Heal, DJ; Kendall, DA; Whitworth, P | 1 |
| Challiss, RA; Kennedy, ED; Nahorski, SR; Ragan, CI | 1 |
| Bartolami, S; Guiramand, J; Lenoir, M; Mayat, E; Pujol, R; Récasens, M; Rumigny, JF | 1 |
| Godfrey, PP; Shipman, L; Watson, SP | 1 |
| Zhang, L | 1 |
| Brown, JH; Brunton, LL; Buxton, IL | 1 |
| Derian, CK; Jessen, ME; Kuo, C; Leeman, SE; Moskowitz, MA | 1 |
| van Woerkom, AE | 1 |
| Godfrey, PP; Grahame-Smith, DG; McClue, SJ; White, AM; Wood, AJ | 1 |
| Gibson, GE; Huang, HM | 1 |
| Busa, WB; Gimlich, RL | 1 |
| Rasmussen, H; Zawalich, KC; Zawalich, WS | 1 |
| Johnson, BG; Schoepp, DD | 1 |
| Godfrey, PP | 1 |
| Bonincontro, A; Cametti, C; elGendy, H; Hausman, RE; Indovina, PL; Santini, MT | 1 |
| Casebolt, TL; Johnson, GV; Jope, RS | 1 |
| Nånberg, E; Nedergaard, J | 1 |
| Monaco, ME | 1 |
| McLeod, JK; Smith, AI; White, LB; Woodcock, EA | 1 |
| Wolniak, SM | 1 |
| Chaudhry, A; Laychock, SG; Rubin, RP | 1 |
| Huang, HM; Sun, GY | 1 |
| Aspley, S; Baker, R; Barnaby, RJ; Billington, DC; Gee, NS; Jackson, RG; Leeson, PD; Ragan, CI; Reid, GG; Watling, KJ | 1 |
| Belmaker, RH; Kaplan, Z; Schreiber, G | 1 |
| Gurpide, E; Weiss, DJ | 1 |
| Graf, P; Sies, H; vom Dahl, S | 1 |
| Parries, GS; Racker, E; Volonté, C | 1 |
| Litosch, I; Pijuan, V | 1 |
| Den Hertog, A; Nelemans, A | 1 |
| Conrad, HE; Fedarko, NS; Ishihara, M | 1 |
| Brown, JH; Masters, SB; Quinn, MT | 1 |
| Montague, W; Morgan, NG; Prince, CA; Rumford, GM | 1 |
| Jackowski, S; Rettenmier, CW; Rock, CO; Sherr, CJ | 1 |
| Davis, JS; Farese, RV; West, LA | 1 |
| Morrow, C; Murphy, S; Pearce, B | 1 |
| Hines, KG; Leigh, JS; Renshaw, CE; Renshaw, PF; Summers, JJ | 1 |
| Andersson, LC; Iivanainen, A; Mustelin, T; Pösö, H | 1 |
| Majerus, PW; Ross, TS | 1 |
| Eisenberg, F; Parthasarathy, R | 1 |
| Dumont, JE; Erneux, C; Graff, I; Laurent, E; Mockel, J | 1 |
| Ananth, US; Hauser, G; Leli, U | 1 |
| Flint, AP; Leat, WM; Sheldrick, EL; Stewart, HJ | 1 |
| Strosznajder, J; Sun, GY; Wikiel, H | 1 |
| Fuchs, A; Malik, Z; Nordenberg, J; Novogrodsky, A; Panet, C; Stenzel, KH; Wasserman, L | 1 |
| Hatanaka, I; Kikkawa, R; Miyamoto, Y; Shigeta, Y; Terada, M; Yamashita, M; Yasuda, H | 1 |
| Kendall, DA; Nahorski, SR | 1 |
| Drachman, DB; Pestronk, A | 1 |
| Martin, TF | 1 |
| Baranes, D; Liu, FT; Razin, E | 1 |
| Drummond, AH; Hughes, PJ; Joels, LA | 1 |
| Andersson, LC; Eloranta, T; Gynther, J; Järvinen, T; Lapinjoki, S; Mustelin, T; Pessa, T | 1 |
| Bennardini, F; Capanni, L; Corti, V; Ledda, F; Mantelli, L; Matucci, R | 1 |
| Andersson, LC; Eloranta, T; Mustelin, T; Pösö, H; Ståhls, A | 1 |
| Catt, KJ; Chang, JP; Morgan, RO | 1 |
| Emura-Yamaguchi, N; Ito, F; Oku, N; Shibamoto, S; Yamaguchi, N | 1 |
| Forer, A; Sillers, PJ | 2 |
| Downes, CP; Stone, MA | 1 |
| Read, AM; Schrey, MP; Steer, PJ | 1 |
| Hasegawa-Sasaki, H | 1 |
| Creba, JA; Doyle, VM; Rüegg, UT | 1 |
| Siess, W | 1 |
| Zatz, M | 1 |
| Batty, I; Nahorski, SR | 1 |
| Lepkifker, E; Lewin, LM; Szeinberg, A | 1 |
| Kaufman, HW; Kleinberg, I | 1 |
| Allison, JH; Stewart, MA | 1 |
| Hauser, G | 1 |
| Roufogalis, BD; Sekar, MC | 1 |
| Hallcher, LM; Honchar, MP; Leavitt, AL; Phillips, BE; Sherman, WR | 1 |
| Honchar, MP; Olney, JW; Sherman, WR | 1 |
| Munsell, LY; Sherman, WR; Wong, YH | 1 |
| Bushfield, M; Drummond, AH; Macphee, CH | 1 |
| Hokin-Neaverson, M; Sadeghian, K | 1 |
| Brown, E; Kendall, DA; Nahorski, SR | 1 |
| Alexander, J; Thomas, AP; Williamson, JR | 1 |
| Daum, PR; Downes, CP; Young, JM | 1 |
| Drummond, AH; Raeburn, CA | 1 |
| Roberts, ML; Tennes, KA | 1 |
| Balla, T; Enyedi, P; Hunyady, L; Spät, A | 1 |
| Berridge, MJ; Downes, CP; Hanley, MR | 1 |
| Allison, JH; Boshans, RL; Hallcher, LM; Packman, PM; Sherman, WR | 1 |
| Curran, EM; Engler, KS; Grady, LH; Taylor, JA; Welshons, WV | 1 |
| Jope, RS; Williams, MB | 2 |
| Batty, IH; Downes, CP | 2 |
| Jope, RS; Li, X | 1 |
| Kofman, O; Levin, U | 1 |
| Agam, G; Belmaker, RH; Benjamin, J; Bersudsky, Y; Kofman, O; Levine, J | 1 |
| Agam, G; Belmaker, RH; Bersudsky, Y; Kofman, O; Shapiro, Y | 1 |
| Belmaker, RH; Katz, V; Kofman, O; Sherman, WR | 1 |
| Bevilacqua, JA; Downes, CP; Lowenstein, PR | 1 |
| Baraban, JM | 1 |
| Atack, JR; Fletcher, SR; McKernan, R; Prior, AM; Quirk, K; Ragan, CI | 1 |
| Géraud, G; Kubiak, J; Lefèvre, B; Maro, B; Pesty, A; Tesarik, J | 1 |
| Belmaker, RH; Grisaru, N | 1 |
| Anelli, R; Calissano, P; D'Mello, SR | 1 |
| Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I | 1 |
| Atack, JR; Griffith, D; Prior, AM; Ragan, CI | 1 |
| Lakin-Thomas, PL | 1 |
| Atack, JR; Cook, SM; Fletcher, SR; Ragan, CI; Watt, AP | 1 |
| Agranoff, BW; Heacock, AM; Seguin, EB | 1 |
| Allan, CJ; Exton, JH | 1 |
| Bakker, AV; Faraci, WS; Jackson, E; Pratt, K; Zorn, SH | 1 |
| Irvine, RF; Wreggett, KA | 1 |
| Batty, I; Bramham, J; Downes, CP; Gani, D | 1 |
| Challiss, RA; Jenkinson, S; Nahorski, SR; Patel, N | 1 |
| Brami, BA; Hauser, G; Leli, U | 1 |
| Downes, CP; Sillence, DJ | 1 |
| Agranoff, BW; Stubbs, EB | 1 |
| Chandler, LJ; Crews, FT; Kurian, P; Narang, N | 1 |
| Häussinger, D; Warskulat, U; Wettstein, M | 1 |
| del Río, E; Downes, CP; Nicholls, DG | 1 |
| Bergsma, JC; De Vries, B; Hiemstra, HS; Van Der Kaay, J; Van Dijken, P; Van Haastert, PJ | 1 |
| Sjöholm, A | 1 |
| Agam, G; Belmaker, RH; Bersudsky, Y; Kofman, O; Levine, J | 1 |
| Ballejo, G; Mataqueiro, MI; Queiroz-Neto, A | 1 |
| Duarte, EP; Oliveira, CR; Rego, AC | 1 |
| Lenox, RH; Watson, DG | 1 |
| Bornemann, A; Guder, WG; Schmolke, M | 1 |
| Allen, PS; Fabian, J; Hanstock, CC; Silverstone, PH; Staab, R | 1 |
| Belmaker, RH; Bersudsky, Y; Chen, G; Manji, HK; Potter, WZ | 1 |
| Moldover, NH; Monaco, ME | 1 |
| Duffy, C; Kane, MT | 1 |
| Belmaker, RH; Richards, MH | 1 |
| Conrad, LJ; Hedgepeth, CM; Huang, HC; Klein, PS; Lee, VM; Zhang, J | 1 |
| Greenberg, ML; Murray, M | 2 |
| Agam, G; Belmaker, RH; Berger, M; Kofman, O; Lubrich, B; Patishi, Y; van Calker, D | 1 |
| Belmaker, RH; Hertz, E; Hertz, L; Wolfson, M | 1 |
| del Río, E; Downes, CP; Nicholls, DG; Shinomura, T; van der Kaay, J | 1 |
| Belmaker, RH; Einat, H; Itkin, O; Kofman, O; Lewitan, RJ | 1 |
| Agam, G; Belmaker, RH; Gavrilov, V; Levine, J | 1 |
| Agam, G; Belmaker, RH; Kofman, O; Richards, MH; van Calker, D | 1 |
| Chuang, DM; Katsube, N; Nonaka, S | 1 |
| Fujimoto, S; Kawakami, N; Shimohama, S; Tanino, H; Tsuda, J | 1 |
| Dreyer, EB; Gorla, M; Katowitz, W; Levin, LA; Simon, P; Vorwerk, CK; Zurakowski, D | 1 |
| Gil-Mascarell, R; Leube, M; Lopez, F; Navarro-Aviñó, JP; Serrano, R | 1 |
| Bannigan, JG; Giles, JJ | 1 |
| Fauroux, CM; Freeman, S | 1 |
| Lubrich, B; van Calker, D | 1 |
| Arfken, CL; Bebchuk, JM; Faulk, MW; Manji, HK; Moore, GJ; Parrish, JK; Strahl-Bevacqua, J | 1 |
| Hasegawa, K; Kinoshita, T; Shiraishi, T | 1 |
| Hanstock, CC; Pukhovsky, A; Rotzinger, S; Silverstone, PH | 1 |
| Inoue, T; Mashimo, T; Shibata, M; Shimizu, T; Wakisaka, S; Yoshiya, I | 1 |
| Balbo, A; Chikhale, EG; Galdzicki, Z; Huang, W; Rapoport, SI; Schapiro, MB; van Gelderen, P | 1 |
| Hall, AC; Lucas, FR; Salinas, PC | 1 |
| Agranoff, BW; Fisher, SK; Novak, JE | 1 |
| Ikonomov, OC; Manji, HK; Petrov, T; Shisheva, A; Soden, K | 1 |
| Belin, T; Davanzo, P; McCracken, J; Oshiro, T; Strober, M; Thomas, MA; Yue, K | 1 |
| Buttenfield, J; Chengappa, KN; Gershon, S; Hardan, A; Kupfer, DJ; Levine, J; Luther, J; Mallinger, AG; Pollock, B; Vagnucci, A; Verfaille, S | 1 |
| Ding, D; Greenberg, ML; Peterson, B; Vaden, DL | 1 |
| Guo, S; Odom, AR; Spiegelberg, BD; Stolz, LE; York, JD | 1 |
| Besra, GS; Nigou, J | 1 |
| Belmaker, RH; Ding, D; Greenberg, ML; Ju, S; Shaldubina, A; Vaden, DL | 1 |
| Besra, GS; Dover, LG; Nigou, J | 1 |
| Agranoff, BW; Fisher, SK | 1 |
| Klár, I; Patocka, J; Strunecká, A | 1 |
| Asghar, SJ; Hanstock, CC; O'Donnell, T; Silverstone, PH; Ulrich, M; Wu, RH | 2 |
| Agam, G; Greenberg, ML; Shaltiel, G; Shamir, A | 1 |
| Steen, VM | 1 |
| Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M | 1 |
| Agam, G; Harwood, AJ | 1 |
| Koyama, T; Nakagawa, S | 1 |
| Pilcher, HR | 1 |
| Gillaspy, GE; Keddie, J; Spence, J; Styer, JC | 1 |
| Berry, GT; Buccafusca, R; Eccleston, E; Greer, JJ | 1 |
| Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M | 1 |
| Agam, G; Dalton, EC; Eickholt, B; Harwood, AJ; Ryves, WJ; Shaltiel, G; Williams, R | 1 |
| Berger, Z; Cook, LJ; Cordenier, A; Floto, RA; Imarisio, S; Pasco, M; Rubinsztein, DC; Sarkar, S | 1 |
| Ding, D; Geiger, JH; Greenberg, ML; Ju, S; Shi, Y; Vaden, DL | 1 |
| King, LS; Phatak, P; Regenold, WT; Shaldivin, A; Shapiro, P | 1 |
| Agam, G; Belmaker, RH; Berry, GT; Bersudsky, Y; Buccafusca, R; Johanson, RA; Klein, PS; O'Brien, WT; Shaldubina, A | 1 |
| Gurling, HM; McQuillin, A; Rizig, M | 1 |
| Geschwind, DH; Palmer, TD; Wexler, EM | 1 |
| Aley, PK; Antoniadou, I; Baldwin, R; Churchill, GC; Halliday, AC; Kuznetsova, OV; Sharp, T; Singh, N; Thomas, JM; Vasudevan, SR; Woon, EC | 1 |
| Agam, G; Belmaker, RH; Berry, GT; Bersudsky, Y; Buccafusca, R; Chalifa-Caspi, V; Moechars, D; Plaschkes, I; Toker, L | 1 |
| Agam, G; Belmaker, RH; Bersudsky, Y; Einat, H; Hadas, I; Kara, N; Toker, L | 1 |
| Bellivier, F; Etain, B; Geoffroy, PA; Leboyer, M | 1 |
| Gondo, Y; Hida, A; Iwayama, Y; Mishima, K; Murata, T; Ohba, H; Ohnishi, T; Watanabe, A; Yoshikawa, T | 1 |
| Churchill, GC; Cowen, PJ; Emir, UE; Gluck, MA; Harmer, CJ; Herzallah, MM; Masaki, C; Sharp, T; Sharpley, AL; Singh, N; Vasudevan, SR | 1 |
| Anghelescu, IG; Correll, CU; Gao, K; Normann, C; Reis, C; Schaffer, A; Solmi, M; van der Loos, ML; Veronese, N; Zaninotto, L | 1 |
| Gonnade, RG; Sardessai, RS; Sarkar, N; Shashidhar, MS; Tamboli, MI | 1 |
| De Sousa, RT; Fernandes, F; Leite, CC; Machado-Vieira, R; Otaduy, MC; Scotti-Muzzi, E; Soeiro-de-Souza, MG | 1 |
| Iwata, N; Kishi, T; Sakuma, K | 1 |
| Greenberg, ML; Lazcano, P; Onu, CJ; Schmidtke, MW | 1 |
| Cantelmi, T; Lepore, E; Unfer, V; Unfer, VR | 1 |
22 review(s) available for inositol and lithium
| Article | Year |
|---|---|
Disruption of phosphoinositide signalling by lithium.
Topics: Animals; Cerebral Cortex; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Phosphatidylinositols; Signal Transduction | 1992 |
Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences.
Topics: Animals; Humans; Inositol; Lithium; Phosphatidylinositols | 1991 |
Myo-inositol attenuates two specific behavioral effects of acute lithium in rats.
Topics: Animals; Behavior, Animal; Inositol; Lithium; Rats | 1991 |
The inositol phospholipids: a stereochemical view of biological activity.
Topics: Inositol; Inositol Phosphates; Lithium; Models, Molecular; Molecular Conformation; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Stereoisomerism | 1986 |
Manipulation of inositol-linked second messenger systems as a therapeutic strategy in psychiatry.
Topics: Animals; Humans; Inositol; Lithium; Mental Disorders; Second Messenger Systems | 1995 |
Toward a crystal-clear view of lithium's site of action.
Topics: Animals; Biological Transport; Brain; Humans; Inositol; Inositol Phosphates; Lithium; Membrane Lipids; Phosphatidylinositols; Phosphoric Monoester Hydrolases | 1994 |
Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression.
Topics: Adult; Aged; Animals; Behavior, Animal; Bipolar Disorder; Brain; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Inositol; Lithium; Male; Middle Aged; Phosphoric Monoester Hydrolases; Rats; Schizophrenia; Second Messenger Systems | 1993 |
Lithium and brain signal transduction systems.
Topics: Animals; Brain; GTP-Binding Proteins; Humans; Inositol; Lithium; Phosphatidylinositols; Receptors, Cholinergic; Second Messenger Systems; Signal Transduction | 1994 |
Lithium and myo-inositol homeostasis.
Topics: Homeostasis; Humans; Inositol; Kinetics; Lithium; Models, Chemical; Phosphoric Monoester Hydrolases | 1993 |
How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Blood-Brain Barrier; Brain; Depressive Disorder; Diuresis; Dose-Response Relationship, Drug; Drinking; Humans; Inositol; Lithium; Rats | 1996 |
Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle: depletion by chronic lithium of brain inositol is specific to hypothalamus, and inositol levels may be abnormal in postmortem br
Topics: Aged; Animals; Antimanic Agents; Behavior; Behavior, Animal; Bipolar Disorder; Brain Chemistry; Female; Humans; Hypothalamus; Inositol; Inositol Phosphates; Isomerism; Lithium; Male; Middle Aged; Rats | 1998 |
Inhibitors of inositol monophosphatase.
Topics: Inositol; Lithium; Organophosphonates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Prodrugs; Psychotropic Drugs; Signal Transduction; Terpenes; Tropolone | 1999 |
An expanded view of inositol signaling.
Topics: Animals; Cell Membrane; Cell Nucleus; Cytoskeleton; Humans; Inositol; Inositol Phosphates; Lithium; Multigene Family; Phytic Acid; RNA, Messenger; Saccharomycetales; Signal Transduction | 2001 |
Inositol, lithium, and the brain.
Topics: Animals; Brain Chemistry; History, 19th Century; History, 20th Century; Humans; Inositol; Lithium; Signal Transduction | 2001 |
[Molecular mechanisms of biological effects of lithium].
Topics: Animals; Bipolar Disorder; Brain; Enzyme Inhibitors; Glycogen; Humans; Inositol; Lithium | 2002 |
Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs.
Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Blood Cells; Enzyme Inhibitors; Eukaryotic Cells; Humans; Inositol; Lithium; Models, Biological; Phosphoric Monoester Hydrolases; Prefrontal Cortex; Saccharomyces cerevisiae; Valproic Acid | 2002 |
Search for a common mechanism of mood stabilizers.
Topics: Affect; Animals; Anticonvulsants; Antimanic Agents; Carbamazepine; Glycogen Synthase Kinase 3; Humans; Inositol; Lithium; Mood Disorders; Signal Transduction; Valproic Acid | 2003 |
[Mechanism and clinical effects of drugs for mood disorder].
Topics: Antidepressive Agents; Antimanic Agents; Biogenic Monoamines; Humans; Inositol; Lithium; Meta-Analysis as Topic; Mood Disorders; Secondary Prevention; Synapses; Treatment Outcome; Valproic Acid | 2003 |
A molecular cell biology of lithium.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Cytoskeleton; Glycogen Synthase Kinase 3; Growth Cones; Humans; Inositol; Lithium; Microtubules; Models, Biological; Neurons | 2004 |
Can the response to mood stabilizers be predicted in bipolar disorder?
Topics: Antimanic Agents; Bipolar Disorder; Circadian Rhythm Signaling Peptides and Proteins; Genetic Association Studies; Genome-Wide Association Study; Humans; Inositol; Lithium; Neurotransmitter Agents; Pharmacogenetics; Phenotype; Valproic Acid | 2014 |
Lamotrigine compared to placebo and other agents with antidepressant activity in patients with unipolar and bipolar depression: a comprehensive meta-analysis of efficacy and safety outcomes in short-term trials.
Topics: Anticonvulsants; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Citalopram; Depression; Depressive Disorder, Major; Drug Combinations; Fluoxetine; Humans; Inositol; Lamotrigine; Lithium; Triazines; Vitamin B Complex | 2016 |
Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis.
Topics: Acetylcysteine; Adult; Double-Blind Method; Female; Humans; Inositol; Lithium; Male; Obsessive-Compulsive Disorder; Randomized Controlled Trials as Topic | 2022 |
7 trial(s) available for inositol and lithium
| Article | Year |
|---|---|
Chronic lithium does not alter human myo-inositol or phosphomonoester concentrations as measured by 1H and 31P MRS.
Topics: Brain; Double-Blind Method; Humans; Inositol; Lithium; Magnetic Resonance Spectroscopy | 1996 |
Effects of lithium and amphetamine on inositol metabolism in the human brain as measured by 1H and 31P MRS.
Topics: Adolescent; Adult; Brain; Central Nervous System Stimulants; Dextroamphetamine; Double-Blind Method; Female; Humans; Inositol; Lithium; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphorus Isotopes; Reference Values; Tritium | 1999 |
Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder.
Topics: Adolescent; Area Under Curve; Aspartic Acid; Bipolar Disorder; Child; Creatine; Demography; Drug Administration Schedule; Female; Gyrus Cinguli; Humans; Inositol; Lithium; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome | 2001 |
Inositol as an add-on treatment for bipolar depression.
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Blood-Brain Barrier; Carbamazepine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Inositol; Lithium; Male; Middle Aged; Pilot Projects; Treatment Outcome; Valproic Acid | 2000 |
Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients.
Topics: Adult; Algorithms; Antimanic Agents; Bipolar Disorder; Brain Chemistry; Female; Frontal Lobe; Humans; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphatidylinositols; Psychiatric Status Rating Scales; Temporal Lobe; Valproic Acid | 2002 |
Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Cerebral Cortex; Choline; Creatine; Drug Administration Schedule; Female; Humans; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Valproic Acid | 2003 |
Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.
Topics: Adult; Antioxidants; Azoles; Brain; Cross-Over Studies; Double-Blind Method; Emotions; Female; Healthy Volunteers; Humans; Inositol; Isoindoles; Learning; Lithium; Male; Organoselenium Compounds; Reinforcement, Psychology; Sleep; Surveys and Questionnaires; Time Factors; Young Adult | 2016 |
196 other study(ies) available for inositol and lithium
| Article | Year |
|---|---|
Increased brain myo-inositol 1-phosphate in lithium-treated rats.
Topics: Animals; Atropine; Brain; Chromatography, Gas; Inositol; Lithium; Male; Mass Spectrometry; Organophosphorus Compounds; Rats; Sodium Chloride | 1976 |
Inhibition of the effect of lithium on brain inositol by atropine and scopolamine.
Topics: Animals; Atropine; Atropine Derivatives; Cerebral Cortex; Inositol; Lithium; Male; Rats; Scopolamine; Scopolamine Derivatives | 1976 |
Cholinergic stimulation of phosphoinositide metabolism in isolated rat glomeruli.
Topics: Animals; Carbachol; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol; Inositol Phosphates; Kidney Glomerulus; Lithium; Male; Mathematics; Parasympathomimetics; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1992 |
Thyroid hormone affects the hydrolysis of inositol phospholipids in the rat hypothalamus.
Topics: Animals; Chlorides; Hydrolysis; Hypothalamus; Hypothyroidism; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Male; Ouabain; Phosphatidylinositols; Rats; Rats, Inbred Strains; Reference Values; Thyroid Gland; Thyroidectomy; Thyroxine | 1992 |
Isolation of adult cardiomyocytes initiates a return of inositol trisphosphate phosphorylating activity.
Topics: Animals; Cells, Cultured; Chlorides; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Lithium Chloride; Myocardium; Norepinephrine; Phosphorylation; Propranolol; Rats; Stimulation, Chemical; Tritium | 1992 |
Age-related differences in the phosphoinositide system in rat neostriatum.
Topics: Aging; Animals; Corpus Striatum; In Vitro Techniques; Inositol; Lithium; Male; Oxotremorine; Phosphatidylinositols; Rats; Rats, Inbred F344 | 1992 |
Intrinsic fluctuations of phosphoinositol levels are involved in the progression of the naturally synchronous cell cycle in Physarum polycephalum.
Topics: Animals; Cell Cycle; Chlorides; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Lithium Chloride; Phosphatidylinositols; Physarum polycephalum; Tritium | 1992 |
Effect of lithium on rat embryos in culture: growth, development, compartmental distribution and lack of a protective effect of inositol.
Topics: Animals; Body Fluid Compartments; Chlorides; Culture Media; Embryo, Mammalian; Embryonic and Fetal Development; Female; Inositol; Kinetics; Lithium; Lithium Chloride; Male; Organ Culture Techniques; Rats; Rats, Wistar | 1992 |
Lithium enhances accumulation of [3H]inositol radioactivity and mass of second messenger inositol 1,4,5-trisphosphate in monkey cerebral cortex slices.
Topics: Acetylcholine; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Macaca mulatta; Second Messenger Systems; Tritium | 1992 |
Inositol passes the blood brain behavior sufficiently to reverse lithium effects on behavior in rats.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Chemistry; Convulsants; Inositol; Lithium; Male; Mannitol; Pilocarpine; Rats | 1992 |
Role of inositol triphosphate isomer formation in type II pneumocyte signal transduction.
Topics: Adenosine Triphosphate; Animals; Calcimycin; Calcium; Cells, Cultured; Chlorides; Chromatography, High Pressure Liquid; Egtazic Acid; Fluorescent Dyes; Indoles; Inositol; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium; Lithium Chloride; Lung; Male; Rats; Signal Transduction | 1991 |
ATP-stimulated inositol phospholipid metabolism and surfactant secretion in rat type II pneumocytes.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cells, Cultured; Chlorides; Choline; Diglycerides; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Lung; Male; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Pulmonary Surfactants; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Action of adenosine in estrogen-primed nonpregnant guinea pig myometrium: characterization of the smooth muscle receptor and coupling to phosphoinositide metabolism.
Topics: Adenosine; Animals; Estrogens; Female; Guinea Pigs; Inositol; Lithium; Muscle, Smooth; Myometrium; Phenylisopropyladenosine; Phosphatidylinositols; Prostaglandins; Receptors, Purinergic; Xanthines | 1991 |
Inositol cycling and phosphoinositide metabolism in rat pancreatic islets.
Topics: Animals; Cells, Cultured; Chlorides; Drug Antagonism; Glucose; Hydrolysis; In Vitro Techniques; Inositol; Inositol Phosphates; Islets of Langerhans; Lithium; Lithium Chloride; Phosphatidylinositols; Rats; Rats, Inbred Strains; Type C Phospholipases | 1991 |
Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain.
Topics: Animals; Brain; Chlorides; Convulsants; Dose-Response Relationship, Drug; Inositol; Lithium; Lithium Chloride; Male; Mice; Mice, Inbred Strains; Phosphoric Monoester Hydrolases; Reaction Time | 1991 |
A new cyclitol derivative influences inositol metabolism in Neurospora crassa.
Topics: Cell Division; Cyclohexanones; Inositol; Lithium; Myo-Inositol-1-Phosphate Synthase; Neurospora crassa; Phosphoric Monoester Hydrolases | 1991 |
Cerebral lithium, inositol and inositol monophosphates.
Topics: Animals; Brain Chemistry; Chlorides; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Male; Mass Spectrometry; Rats; Rats, Inbred Strains | 1991 |
Evidence for coupling of resynthesis to hydrolysis in the phosphoinositide cycle.
Topics: Animals; Chlorides; Hydrolysis; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Mammary Neoplasms, Experimental; Phosphates; Phosphatidylinositols; Rats; Tumor Cells, Cultured; Vasopressins | 1991 |
Lithium-induced decrease of brain inositol and increase of brain inositol-1-phosphate is transient.
Topics: Analysis of Variance; Animals; Brain; Chlorides; Dose-Response Relationship, Drug; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Male; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Effects of acute and chronic ethanol administration on phosphoinositide metabolism in mouse brain.
Topics: Animals; Brain; Drug Administration Schedule; Ethanol; Inositol; Lithium; Mice; Mice, Inbred C57BL; Models, Biological; Phosphatidylinositol Phosphates; Phosphatidylinositols; Tritium | 1991 |
A method to measure simultaneously cyclic AMP and inositol phosphate accumulation in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cerebral Cortex; Cyclic AMP; Evaluation Studies as Topic; Inositol; Inositol Phosphates; Lithium; Male; Methods; Norepinephrine; Rats; Rats, Inbred Strains | 1991 |
Increases in Na/K pump numbers in isolated human lymphocytes exposed to lithium in vitro. Reversal by myo-inositol and by inhibitors of protein kinase C and the Na/H antiport.
Topics: Adult; Alkaloids; Amiloride; Carrier Proteins; Female; Humans; Inositol; Lithium; Lymphocytes; Male; Ouabain; Potassium; Protein Kinase C; Rubidium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Staurosporine | 1991 |
Intracerebroventricular myo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Chlorides; Injections, Intraventricular; Inositol; Lithium; Lithium Chloride; Male; Motor Activity; Rats; Reference Values | 1990 |
Potentiation by gamma-aminobutyric acid of alpha 1-agonist-induced accumulation of inositol phosphates in slices of rat cerebral cortex.
Topics: Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inositol; Inositol Phosphates; Lithium; Male; Norepinephrine; Phospholipids; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors | 1990 |
Effect of prolonged in vitro lithium treatment on calcium transients in frog twitch muscle fibres and its reversal by exogenous myo-inositol.
Topics: Animals; Calcium; Evoked Potentials; In Vitro Techniques; Inositol; Kinetics; Lithium; Muscles; Ranidae | 1990 |
Stimulus-responsive and rapid formation of inositol pentakisphosphate in cultured adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Egtazic Acid; Endothelins; Inositol; Inositol Phosphates; Kinetics; Lithium; Marine Toxins; Nicotine; Nifedipine; Oxocins; Platelet-Derived Growth Factor; Potassium; Tetradecanoylphorbol Acetate; Veratridine | 1990 |
Thyrotropin-releasing hormone receptor occupancy determines the fraction of the responsive pool of inositol lipids hydrolysed in rat pituitary tumour cells.
Topics: Animals; Chlorides; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Phosphatidylinositols; Pituitary Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1990 |
Thyrotrophin-releasing hormone stimulates polyphosphoinositide metabolism in the frog neurointermediate lobe.
Topics: alpha-MSH; Animals; Chlorides; Inositol; Lithium; Lithium Chloride; Male; Membrane Lipids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Pituitary Gland, Anterior; Rana ridibunda; Second Messenger Systems; Thyrotropin-Releasing Hormone | 1990 |
Muscarinic receptor-mediated inositol tetrakisphosphate response in bovine adrenal chromaffin cells.
Topics: 2,3-Diphosphoglycerate; Adrenal Medulla; Animals; Atropine; Cattle; Cells, Cultured; Chlorides; Diphosphoglyceric Acids; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Muscarine; Receptors, Muscarinic; Second Messenger Systems | 1990 |
The effects of acute and chronic lithium treatment on pilocarpine-stimulated phosphoinositide hydrolysis in mouse brain in vivo.
Topics: Animals; Atropine; Brain; Diet; Hydrolysis; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositols; Pilocarpine | 1990 |
Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices.
Topics: Animals; Cerebral Cortex; In Vitro Techniques; Inositol; Inositol Phosphates; Lithium; Male; Rats; Rats, Inbred Strains | 1990 |
A M3 muscarinic receptor coupled to inositol phosphate formation in the rat cochlea?
Topics: Animals; Carbachol; Cells, Cultured; Cochlea; Inositol; Inositol Phosphates; Lithium; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium | 1990 |
Lithium research: state of the art.
Topics: Animals; Bipolar Disorder; Brain; Depressive Disorder; Humans; Inositol; Inositol Phosphates; Lithium; Orphan Drug Production | 1990 |
Lithium potentiates agonist formation of [3H]CDP-diacylglycerol in human platelets.
Topics: Blood Platelets; Cytidine; Cytidine Diphosphate Diglycerides; Humans; In Vitro Techniques; Inositol; Lithium; Nucleoside Diphosphate Sugars; Phosphatidylinositols; Thrombin | 1990 |
Effects of inositol, 1,4,5-trisphosphate injections into cat spinal motoneurons.
Topics: Anesthesia; Animals; Calcium; Cats; Chelating Agents; Decerebrate State; Electric Stimulation; Injections; Inositol; Inositol 1,4,5-Trisphosphate; Iontophoresis; Lithium; Motor Neurons; Potassium Channels; Spinal Cord | 1990 |
Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.
Topics: Animals; Calcimycin; Calcium; Carbachol; Chlorides; Heart; Hydrolysis; Inositol; Inositol Phosphates; Ion Channels; Kinetics; Lithium; Lithium Chloride; Male; Myocardium; Norepinephrine; Phosphatidylinositols; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1985 |
Desensitization to substance P-induced vasodilation in vitro is not shared by endogenous tachykinin neurokinin A.
Topics: Animals; Atropine; Basilar Artery; Brain; Carotid Arteries; Chlorides; Dogs; In Vitro Techniques; Indomethacin; Inositol; Lithium; Lithium Chloride; Neurokinin A; Neuropeptides; Propranolol; Radioimmunoassay; Substance P; Tachykinins; Vasodilation | 1987 |
The end organ defect in cystic fibrosis; a hypothesis: disinhibited inositol cycle activation?
Topics: Blood Proteins; Calcium; Cell Membrane Permeability; Chlorides; Ciliary Motility Disorders; Cystic Fibrosis; Humans; Inositol; Ion Channels; Lithium; Models, Biological; Phosphatidylinositols | 1987 |
Subacute and chronic in vivo lithium treatment inhibits agonist- and sodium fluoride-stimulated inositol phosphate production in rat cortex.
Topics: Animals; Carbachol; Cell Membrane; Cerebral Cortex; Chlorides; Cyclic AMP; Inositol; Inositol Phosphates; Isoproterenol; Kinetics; Lithium; Lithium Chloride; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Serotonin; Serotonin; Sodium Fluoride; Sugar Phosphates; Type C Phospholipases | 1989 |
Phosphatidylinositol metabolism during in vitro hypoxia.
Topics: Animals; Calcium; Cerebral Cortex; Chlorides; Hypoxia; Inositol; Lithium; Lithium Chloride; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Potassium Chloride; Potassium Cyanide; Rats; Rats, Inbred Strains | 1989 |
Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog.
Topics: Abnormalities, Drug-Induced; Animals; Blastomeres; Central Nervous System; Diglycerides; Exocrine Glands; Eye; Glycerides; Inositol; Lithium; Microelectrodes; Microinjections; Mutation; Phosphatidylinositol Phosphates; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Xenopus laevis | 1989 |
Interactions between lithium, inositol and mono-oleoylglycerol in the regulation of insulin secretion from isolated perifused rat islets.
Topics: Animals; Cell Separation; Chlorides; Glycerides; Inositol; Insulin; Insulin Secretion; Islets of Langerhans; Lithium; Lithium Chloride; Male; Rats; Rats, Inbred Strains | 1989 |
Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus by 2-amino-3-phosphonopropionate.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Carbachol; Chlorides; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Inositol; Kainic Acid; Kinetics; Lithium; Lithium Chloride; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol.
Topics: Animals; Carbachol; Cerebral Cortex; Cytidine Diphosphate Diglycerides; In Vitro Techniques; Inositol; Lithium; Male; Nucleoside Diphosphate Sugars; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1989 |
Rescue of the Li+-induced delay of embryonic myogenesis in vitro by added inositol.
Topics: Animals; Cell Adhesion; Cell Aggregation; Cell Differentiation; Cell Membrane; Cells, Cultured; Chick Embryo; Electric Conductivity; Inositol; Kinetics; Lithium; Muscles | 1989 |
Modulation of carbachol-stimulated inositol phospholipid hydrolysis in rat cerebral cortex.
Topics: Animals; Carbachol; Cell Membrane; Cerebral Cortex; Chlorides; Guanosine Triphosphate; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Male; Phosphatidylinositols; Rats; Sugar Phosphates; Tritium | 1987 |
Alpha 1-adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent.
Topics: Adipose Tissue, Brown; Animals; Cells, Cultured; Cricetinae; Egtazic Acid; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Mesocricetus; Norepinephrine; Oxygen Consumption; Receptors, Adrenergic, alpha; Sodium; Sugar Phosphates | 1987 |
Inositol metabolism in WRK-1 cells. Relationship of hormone-sensitive to -insensitive pools of phosphoinositides.
Topics: Animals; Cell Line; Chlorides; Inositol; Kinetics; Lithium; Lithium Chloride; Phosphates; Phosphatidylinositols; Phosphorus Radioisotopes; Tritium; Vasopressins | 1987 |
Stimulation of phosphatidylinositol metabolism in the isolated, perfused rat heart.
Topics: Animals; Atropine; Bucladesine; Calcium; Carbachol; Chlorides; Heart Atria; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Lithium Chloride; Male; Mast Cells; Myocardium; Norepinephrine; Perfusion; Phosphatidylinositols; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1987 |
Lithium alters mitotic progression in stamen hair cells of Tradescantia in a time-dependent and reversible fashion.
Topics: Anaphase; Calcium Chloride; Chlorides; Inositol; Lithium; Lithium Chloride; Metaphase; Mitosis; Plant Cells; Prophase; Time Factors | 1987 |
The effects of fatty acids on phosphoinositide synthesis and myo-inositol accumulation in exocrine pancreas.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carbachol; Chlorides; Fatty Acids; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Male; Pancreas; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1987 |
Effects of ATP on phosphatidylinositol-phospholipase C and inositol 1-phosphate accumulation in rat brain synaptosomes.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium; Cell Membrane; Cell Membrane Permeability; Chlorides; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Lysophospholipids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Sugar Phosphates; Synaptosomes | 1988 |
The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate.
Topics: Animals; Brain; Chlorides; Chromatography, High Pressure Liquid; Hydrolysis; In Vitro Techniques; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Liver; Phosphoric Monoester Hydrolases; Rats; Sugar Phosphates | 1988 |
Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity. Short note.
Topics: Animals; Antidotes; Chlorides; Colforsin; Dose-Response Relationship, Drug; Inositol; Lithium; Lithium Chloride; Male; Mice; Mice, Inbred BALB C | 1988 |
Regulation of phosphoinositide hydrolysis in transformed human endometrial cells.
Topics: Acetylcholine; Adenocarcinoma; Atropine; Carbachol; Cell Differentiation; Chlorides; Endometrium; Female; Humans; Hydrolysis; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Phorbol Esters; Phosphatidylinositols; Receptors, Muscarinic; Tamoxifen; Tumor Cells, Cultured; Uterine Neoplasms | 1988 |
Hepatic inositol release upon hormonal stimulation of perfused rat liver.
Topics: Angiotensin II; Animals; Bucladesine; Calcium; Chlorides; Glucagon; Hormones; Inositol; Lithium; Lithium Chloride; Liver; Lypressin; Male; Oxygen Consumption; Phenylephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1988 |
Stimulation of inositol incorporation into lipids of PC12 cells by nerve growth factor and bradykinin.
Topics: Adrenal Gland Neoplasms; Animals; Bradykinin; Calcimycin; Chlorides; Inositol; Inositol Phosphates; Lipid Metabolism; Lithium; Lithium Chloride; Nerve Growth Factors; Pheochromocytoma; Phosphatidylinositols; Rats; Tumor Cells, Cultured | 1988 |
GABAB receptor-mediated inhibition of histamine H1-receptor-induced inositol phosphate formation in slices of rat cerebral cortex.
Topics: Animals; Baclofen; Carbachol; Cerebral Cortex; gamma-Aminobutyric Acid; Histamine; Inositol; Inositol Phosphates; Isonicotinic Acids; Kinetics; Lithium; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Histamine H1; Sugar Phosphates | 1988 |
Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta.
Topics: Animals; Aorta, Thoracic; Chlorides; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Male; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Inbred Strains; Reference Values; Sugar Phosphates | 1988 |
Changes in membrane potential and phosphoinositides during alpha 1-adrenoceptor stimulation in smooth muscle cells of guinea-pig taenia caeci.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Cecum; Epinephrine; Female; Guinea Pigs; In Vitro Techniques; Inositol; Lithium; Male; Membrane Potentials; Muscle, Smooth; Phosphatidylinositols | 1987 |
Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparan sulfate metabolism and hepatocyte growth.
Topics: Animals; Biological Transport, Active; Cell Line; Chondroitin Sulfate Proteoglycans; Contact Inhibition; Extracellular Matrix; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Inositol; Inositol Phosphates; Insulin; Lithium; Liver; Phosphatidylinositols; Proteoglycans; Rats | 1987 |
Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.
Topics: Astrocytoma; Calcium; Carbachol; Cell Line; Chromatography, Ion Exchange; Humans; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; N-Methylscopolamine; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1985 |
Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans.
Topics: Animals; Carbohydrates; Chlorides; Egtazic Acid; Glucose; In Vitro Techniques; Inositol; Islets of Langerhans; Lithium; Lithium Chloride; Male; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1985 |
A guanine nucleotide-dependent phosphatidylinositol 4,5-diphosphate phospholipase C in cells transformed by the v-fms and v-fes oncogenes.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chlorides; Epithelium; Guanine Nucleotides; Inositol; Kinetics; Lithium; Lithium Chloride; Lung; Mink; Oncogenes; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphotransferases; Retroviridae; Sarcoma Viruses, Feline; Type C Phospholipases | 1986 |
Gonadotropin-releasing hormone (GnRH) rapidly stimulates the formation of inositol phosphates and diacyglycerol in rat granulosa cells: further evidence for the involvement of Ca2+ and protein kinase C in the action of GnRH.
Topics: Animals; Calcium; Chlorides; Diglycerides; Female; Glycerides; Gonadotropin-Releasing Hormone; Granulosa Cells; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Inbred Strains; Sugar Phosphates | 1986 |
Receptor-mediated inositol phospholipid hydrolysis in astrocytes.
Topics: Animals; Astrocytes; Calcimycin; Calcium; Carbachol; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Hydrolysis; Inositol; Inositol Phosphates; Lithium; Membrane Lipids; Norepinephrine; Phosphatidylinositols; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Time Factors | 1986 |
Changes in the 31P-NMR spectra of cats receiving lithium chloride systemically.
Topics: Animals; Cerebral Cortex; Chlorides; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Phosphates; Phosphoric Monoester Hydrolases; Rats; Sugar Phosphates | 1986 |
myo-Inositol reverses Li+-induced inhibition of phosphoinositide turnover and ornithine decarboxylase induction during early lymphocyte activation.
Topics: Chlorides; Depression, Chemical; Enzyme Induction; Humans; Inositol; Lithium; Lithium Chloride; Lymphocyte Activation; Ornithine Decarboxylase; Phosphatidylinositols; T-Lymphocytes | 1986 |
Isolation of D-myo-inositol 1:2-cyclic phosphate 2-inositolphosphohydrolase from human placenta.
Topics: Annexin A3; Calcium; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Female; Humans; Inositol; Inositol Phosphates; Kinetics; Lithium; Magnesium; Manganese; Molecular Weight; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Placenta; Pregnancy; Zinc | 1986 |
Carbachol and sodium fluoride, but not TSH, stimulate the generation of inositol phosphates in the dog thyroid.
Topics: Animals; Atropine; Carbachol; Chlorides; Dogs; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Phorbol 12,13-Dibutyrate; Phorbol Esters; Sodium Fluoride; Sugar Phosphates; Thyroid Gland; Thyrotropin; Tritium | 1987 |
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphates; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Serotonin; Spiperone | 1987 |
Stimulation of phosphoinositide hydrolysis by oxytocin and the mechanism by which oxytocin controls prostaglandin synthesis in the ovine endometrium.
Topics: Animals; Chlorides; Endometrium; Female; Hydrolysis; Inositol; Lipoprotein Lipase; Lithium; Lithium Chloride; Oxytocin; Phosphatidylinositols; Prostaglandins; Sheep; Stimulation, Chemical; Uterus | 1986 |
Effects of cerebral ischemia on [3H]inositol lipids and [3H]inositol phosphates of gerbil brain and subcellular fractions.
Topics: Animals; Brain; Gerbillinae; Inositol; Inositol Phosphates; Ischemic Attack, Transient; Lithium; Phosphatidylinositols; Sugar Phosphates; Synaptosomes; Tritium | 1987 |
The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Chlorides; Clone Cells; Humans; Inositol; Lithium; Lithium Chloride; Melanoma; Mice; Mice, Inbred C57BL; NADH Dehydrogenase; Neoplasm Transplantation | 1987 |
Thyrotropin-releasing hormone reduces myo-inositol content in rat cerebellum pretreated with lithium.
Topics: Animals; Cerebellum; Cerebral Cortex; Chlorides; Inositol; Lithium; Lithium Chloride; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Thyrotropin-Releasing Hormone | 1987 |
Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex.
Topics: Animals; Carbachol; Cerebral Cortex; Histamine; Hydrolysis; Inositol; Lithium; Male; Norepinephrine; Phosphatidylinositols; Potassium; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Mechanism of action of lithium on acetylcholine receptor metabolism in skeletal muscle.
Topics: Animals; Bucladesine; Calcimycin; Calcium; Cells, Cultured; Inositol; Lithium; Muscles; Receptors, Cholinergic | 1987 |
Measurement of phospholipid turnover in cultured hormone responsive pituitary cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chromatography, Thin Layer; Diglycerides; Fatty Acids, Nonesterified; Glycerol; Inositol; Lithium; Phosphates; Phospholipids; Phosphorus Radioisotopes; Pituitary Neoplasms; Radioisotope Dilution Technique; Rats; Thyrotropin-Releasing Hormone; Tritium | 1986 |
Thrombin and IgE antigen induce formation of inositol phosphates by mouse E-mast cells.
Topics: Animals; Antigens; Calcium; Cells, Cultured; Chondroitin; Chondroitin Sulfates; Immunoglobulin E; Inositol; Inositol Phosphates; Lithium; Mast Cells; Mice; Sugar Phosphates; Thrombin | 1986 |
The interaction of lithium ions with inositol lipid signalling systems.
Topics: Animals; Cell Line; Inositol; Inositol Phosphates; Kinetics; Lithium; Models, Biological; Sugar Phosphates; Thyrotropin-Releasing Hormone | 1987 |
Two phases of ornithine decarboxylase activation during lymphocyte mitogenesis.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Chlorides; Chromatography, Gas; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; In Vitro Techniques; Inositol; Lithium; Lymphocyte Activation; Mass Spectrometry; Ornithine Decarboxylase; Polyamines; Precipitin Tests; Protein Kinase C; T-Lymphocytes | 1988 |
Influence of lithium on the positive inotropic effect of phenylephrine and isoprenaline in guinea-pig heart.
Topics: Animals; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Inositol; Isoproterenol; Lithium; Male; Myocardial Contraction; Phenylephrine; Phosphatidylinositols; Stimulation, Chemical | 1988 |
Transduction of mitogenic signals in T lymphocytes. Role of inositol phospholipids for the rapid activation of ornithine decarboxylase.
Topics: Enzyme Activation; Humans; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Lymphocyte Activation; Ornithine Decarboxylase; Phosphatidylinositols; Putrescine; T-Lymphocytes | 1987 |
Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Gonadotropin-Releasing Hormone; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Phosphates; Pituitary Gland, Anterior; Rats; Sugar Phosphates; Type C Phospholipases | 1987 |
Distinct effects of Na+ and Li+ on the induction of morphological changes in A431 cells mediated by epidermal growth factor.
Topics: Carcinoma, Squamous Cell; Cell Line; Cytoplasm; Epidermal Growth Factor; Humans; Inositol; Lithium; Microscopy, Phase-Contrast; Phosphates; Potassium; Skin Neoplasms; Sodium; Vanadium | 1987 |
The role of the phosphatidylinositol cycle in mitosis in sea urchin zygotes. Lithium inhibition is overcome by myo-inositol but not by other cyclitols or sugars.
Topics: Animals; Cell Cycle; Fertilization; Inositol; Lithium; Mitosis; Phosphatidylinositols; Sea Urchins; Sugar Alcohols; Zygote | 1987 |
Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland.
Topics: Animals; Carbachol; In Vitro Techniques; Inositol; Intracellular Fluid; Lithium; Parotid Gland; Phosphatidylinositols; Rats; Receptors, Muscarinic; Stimulation, Chemical | 1986 |
Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidua cells.
Topics: Arginine Vasopressin; Calcium; Decidua; Female; Humans; Hydrolysis; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Myometrium; Oxytocin; Phosphatidylinositols; Pregnancy; Sugar Phosphates | 1986 |
Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Dinoprostone; Fibroblasts; Glycerides; Inositol; Lipid Metabolism; Lithium; Mice; Phosphatidic Acids; Phosphatidylinositols; Platelet-Derived Growth Factor; Prostaglandins E | 1985 |
Platelet-activating factor mobilizes intracellular calcium in vascular smooth muscle cells.
Topics: Animals; Aorta; Calcium; Cell Line; Inositol; Inositol Phosphates; Kinetics; Lithium; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Sugar Phosphates | 1986 |
CA++ in fertilization and mitosis: the phosphatidylinositol cycle in sea urchin gametes and zygotes is involved in control of fertilization and mitosis.
Topics: Animals; Calcium; Female; Fertilization; Inositol; Lithium; Male; Mitosis; Phosphatidylinositols; Sea Urchins; Seawater | 1985 |
Evidence for the formation of inositol 4-monophosphate in stimulated human platelets.
Topics: Blood Platelets; Chromatography, High Pressure Liquid; Humans; Inositol; Inositol Phosphates; Kinetics; Lithium; Sugar Phosphates; Thrombin; Vasopressins | 1985 |
Denervation supersensitivity of the rat pineal to norepinephrine-stimulated [3H]inositide turnover revealed by lithium and a convenient procedure.
Topics: Animals; Denervation; Inositol; Inositol Phosphates; Kinetics; Lithium; Male; Norepinephrine; Phosphatidylinositols; Pineal Gland; Rats; Rats, Inbred Strains | 1985 |
Differential effects of lithium on muscarinic receptor stimulation of inositol phosphates in rat cerebral cortex slices.
Topics: Animals; Carbachol; Carbon Radioisotopes; Cerebral Cortex; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Male; Rats; Receptors, Muscarinic; Sugar Phosphates; Tritium | 1985 |
Gas chromatography measurement of myo-inositol in human blood, cerebrospinal fluid and seminal fluid.
Topics: Adult; Aged; Child, Preschool; Chromatography, Gas; Chromatography, Ion Exchange; Creatine Kinase; Depression; Drug Stability; Female; Hot Temperature; Humans; Hyperbilirubinemia; Hyperglycemia; Infant; Inositol; Lithium; Male; Middle Aged; Semen; Time Factors; Uremia | 1973 |
The effect of pH on the adsorption properties of the phytate molecule.
Topics: Adsorption; Chemical Phenomena; Chemistry, Physical; Chlorides; Dental Caries; Hydrogen-Ion Concentration; Inositol; Ion Exchange Resins; Lithium; Plants; Sodium; Soil | 1970 |
Reduced brain inositol in lithium-treated rats.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Injections, Intraperitoneal; Inositol; Lithium; Male; Rats; Time Factors | 1971 |
Myo-inositol transport in slices of rat kidney cortex. II. Effect of the ionic composition of the medium.
Topics: Adenosine Triphosphate; Ammonia; Animals; Calcium; Cesium; Choline; Culture Media; Glucose; In Vitro Techniques; Inositol; Kidney; Lithium; Magnesium; Ouabain; Potassium; Rats; Rubidium; Sodium | 1969 |
Muscarinic-receptor stimulation enhances polyphosphoinositide breakdown in guinea-pig ileum smooth muscle.
Topics: Animals; Atropine; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Inositol; Lithium; Muscle, Smooth; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Receptors, Muscarinic; Stimulation, Chemical | 1984 |
Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat.
Topics: Animals; Cerebral Cortex; Chlorides; Inositol; Inositol Phosphates; Isomerism; Lithium; Lithium Chloride; Male; Phosphoric Monoester Hydrolases; Rats; Sugar Phosphates | 1981 |
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Topics: Animals; Atropine; Brain Chemistry; Chlorides; Drug Interactions; Humans; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Male; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Substance-Related Disorders | 1983 |
Differential uptake of lithium isotopes by rat cerebral cortex and its effect on inositol phosphate metabolism.
Topics: Animals; Biological Transport; Cerebral Cortex; Chlorides; Inositol; Inositol Phosphates; Isotopes; Lithium; Lithium Chloride; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Studies with lithium.
Topics: Animals; Calcimycin; Cell Line; Inositol; Lithium; Phosphatidylinositols; Pituitary Gland; Rats; Thyrotropin-Releasing Hormone | 1984 |
Lithium-induced accumulation of inositol 1-phosphate during cholecystokinin octapeptide- and acetylcholine-stimulated phosphatidylinositol breakdown in dispersed mouse pancreas acinar cells.
Topics: Acetylcholine; Animals; Inositol; Inositol Phosphates; Kinetics; Lithium; Male; Mice; Mice, Inbred Strains; Pancreas; Phosphatidylinositols; Sincalide | 1984 |
Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterisation.
Topics: Animals; Cerebral Cortex; Histamine; In Vitro Techniques; Inositol; Kinetics; Lithium; Male; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Serotonin | 1984 |
Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.
Topics: Animals; Calcimycin; Calcium; Chlorides; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Liver; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylase a; Rats; Rats, Inbred Strains; Sugar Phosphates; Vasopressins | 1984 |
Histamine stimulation of inositol 1-phosphate accumulation in lithium-treated slices from regions of guinea pig brain.
Topics: Animals; Brain; Cyclic AMP; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Inositol; Inositol Phosphates; Lithium; Male; Pyrilamine; Receptors, Histamine H1; Time Factors | 1984 |
The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation.
Topics: Animals; Cell Line; Diglycerides; Glycerides; Inositol; Lipid Metabolism; Lithium; Phospholipids; Pituitary Neoplasms; Rats; Thyrotropin-Releasing Hormone | 1984 |
The contribution of inositol exchange to agonist-stimulated breakdown of myo- [2-3H] inositol-labelled phosphatidylinositol in mouse exocrine pancreas.
Topics: Animals; Carbachol; In Vitro Techniques; Inositol; Lithium; Mice; Pancreas; Phosphatidylinositols | 1984 |
Effects of lithium on angiotensin-stimulated phosphatidylinositol turnover and aldosterone production in adrenal glomerulosa cells: a possible causal relationship.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Animals; Inositol; Inositol Phosphates; Lithium; Male; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1984 |
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.
Topics: Animals; Cerebral Cortex; Diptera; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Inositol; Inositol Phosphates; Lithium; Male; Phosphatidylinositols; Rats; Rats, Inbred Strains; Salivary Glands | 1982 |
The effects of lithium on myo-inositol levels in layers of frontal cerebral cortex, in cerebellum, and in corpus callosum of the rat.
Topics: Animals; Cerebellum; Corpus Callosum; Frontal Lobe; Inositol; Lithium; Male; Rats; Receptors, Cholinergic | 1980 |
Lithium-stimulated proliferation and alteration of phosphoinositide metabolites in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Survival; Epidermal Growth Factor; Growth Substances; Humans; In Vitro Techniques; Inositol; Inositol Phosphates; Lithium; Mitogens; Phosphatidylinositols; Tumor Cells, Cultured | 1995 |
Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats.
Topics: Amphetamines; Animals; Cholinergic Agents; Drug Synergism; Inositol; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Serotonin Receptor Agonists | 1995 |
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+.
Topics: Astrocytoma; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; Enzyme Activation; Inositol; Lithium; Osmolar Concentration; Phosphatidylinositols; Receptors, Muscarinic; Transferases (Other Substituted Phosphate Groups); Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Selective inhibition of the expression of signal transduction proteins by lithium in nerve growth factor-differentiated PC12 cells.
Topics: Animals; Cell Differentiation; GTP-Binding Proteins; Inositol; Lithium; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein Kinase C; Rats; Signal Transduction; Type C Phospholipases; Tyrosine | 1995 |
Myo-inositol attenuates the enhancement of the serotonin syndrome by lithium.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Colforsin; Drug Interactions; Inositol; Lithium; Male; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 1995 |
High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Chromatography, Gas; Glucose; Injections, Intraperitoneal; Injections, Intraventricular; Inositol; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Inositol; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus.
Topics: Animals; Autoradiography; Carbachol; Cerebral Cortex; Cycloleucine; Cytidine Monophosphate; Female; Glycerophospholipids; Hippocampus; In Vitro Techniques; Inositol; Lithium; Neurons; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Wistar; Stimulation, Chemical | 1994 |
Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.
Topics: Animals; Carbachol; Cell Membrane Permeability; Cerebral Cortex; CHO Cells; Cricetinae; Cytidine; Cytidine Monophosphate; Diphosphonates; Glycerophospholipids; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Male; Phosphatidic Acids; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Prodrugs; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Tritium | 1994 |
Mouse oocyte maturation is affected by lithium via the polyphosphoinositide metabolism and the microtubule network.
Topics: Actin Cytoskeleton; Animals; Chromosomes; Female; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Mice; Microtubules; Oocytes; Oogenesis; Phosphatidylinositol Phosphates | 1994 |
The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells.
Topics: Culture Media; Humans; Inositol; Lithium; Phosphatidylinositols; Receptors, Muscarinic; Tumor Cells, Cultured; Type C Phospholipases | 1994 |
Lithium dosage and inositol levels.
Topics: Bipolar Disorder; Dose-Response Relationship, Drug; Humans; Inositol; Lithium; Male; Middle Aged; Psoriasis | 1994 |
Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Inositol; Lithium; Neurons; Potassium; Rats; Signal Transduction | 1994 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Synergism; Glucose; Inositol; Lithium; Male; Motor Activity; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior | 1993 |
Characterization of the effects of lithium on phosphatidylinositol (PI) cycle activity in human muscarinic m1 receptor-transfected CHO cells.
Topics: Animals; Carbachol; CHO Cells; Cricetinae; Cytidine Monophosphate; Humans; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Phosphatidylinositols; Radioligand Assay; Receptors, Muscarinic; Second Messenger Systems; Transfection | 1993 |
Evidence against a direct role for inositol phosphate metabolism in the circadian oscillator and the blue-light signal transduction pathway in Neurospora crassa.
Topics: Circadian Rhythm; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Light; Lithium; Neurospora crassa; Signal Transduction | 1993 |
Depression of calcium transients after exposure to high K+ solution in Li(+)-loaded frog twitch muscle fibres and its reversal by exogenous myo-inositol.
Topics: Animals; Calcium; In Vitro Techniques; Inositol; Lithium; Membrane Potentials; Muscles; Potassium; Ranidae | 1993 |
In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.
Topics: Animals; Brain; Cattle; CHO Cells; Cricetinae; Diphosphonates; Dose-Response Relationship, Drug; Frontal Lobe; Humans; Inositol; Inositol Phosphates; Kidney; Kinetics; Lithium; Liver; Male; Mice; Organophosphonates; Phosphoric Monoester Hydrolases; Rats; Recombinant Proteins; Testis | 1993 |
Measurement of receptor-activated phosphoinositide turnover in rat brain: nonequivalence of inositol phosphate and CDP-diacylglycerol formation.
Topics: Animals; Brain; Cytidine Diphosphate Diglycerides; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface | 1993 |
Quantification of inositol phospholipid breakdown in isolated rat hepatocytes.
Topics: Animals; Diglycerides; Ethanol; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Liver; Male; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Vasopressins | 1993 |
Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation.
Topics: Animals; Beryllium; Binding, Competitive; Brain; Cattle; Humans; Hydrolysis; Inositol; Inositol Phosphates; Kinetics; Lithium; Neuroblastoma; Phosphoric Monoester Hydrolases; Rats; Tumor Cells, Cultured | 1993 |
Evidence for receptor-specific regulation of the metabolism of the second messenger, inositol trisphosphate, in human endothelial cells.
Topics: Cells, Cultured; Chlorides; Chromatography, Ion Exchange; Endothelium, Vascular; Histamine; Humans; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isomerism; Kinetics; Lithium; Lithium Chloride; Models, Biological; Second Messenger Systems; Thrombin; Time Factors; Umbilical Veins | 1993 |
Comparative effects of lithium on the phosphoinositide cycle in rat cerebral cortex, hippocampus, and striatum.
Topics: Animals; Carbachol; Cerebral Cortex; Corpus Striatum; Cytidine Monophosphate; Hippocampus; Inositol; Inositol Phosphates; Lithium; Male; Osmolar Concentration; Phosphatidic Acids; Phosphatidylinositols; Rats | 1993 |
Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells.
Topics: Animals; Bradykinin; Cytidine Monophosphate; Diglycerides; Glioma; Hybrid Cells; Inositol; Lithium; Neuroblastoma; Phosphatidic Acids; Tumor Cells, Cultured | 1993 |
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
Topics: Astrocytoma; Carbachol; Humans; Inositol; Lithium; Phosphatidylinositols; Propranolol; Tumor Cells, Cultured | 1993 |
Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells.
Topics: Atropine; Carbachol; Cytidine Diphosphate Diglycerides; Humans; Inositol; Kinetics; Lithium; Neuroblastoma; Receptors, Muscarinic; Tumor Cells, Cultured | 1993 |
Radio-label and mass determinations of inositol 1,3,4,5-tetrakisphosphate formation in rat cerebral cortical slices: differential effects of myo-inositol.
Topics: Animals; Carbachol; Cerebral Cortex; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Male; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Betaine is an osmolyte in RAW 264.7 mouse macrophages.
Topics: Aminoisobutyric Acids; Animals; Betaine; Biological Transport; Carrier Proteins; Cell Line; Chlorides; Choline; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Inositol; Lithium; Macrophages; Mice; Osmolar Concentration; RNA, Messenger; Sodium | 1995 |
Characterization of the effects of lithium and inositol on phosphoinositide turnover in cerebellar granule cells in primary culture.
Topics: Animals; Cells, Cultured; Cerebellum; Cytidine Monophosphate; Extracellular Space; Glycerophospholipids; Inositol; Lithium; Lithium Chloride; Neurons; Phosphatidic Acids; Phosphatidylinositols; Rats | 1996 |
Dictyostelium discoideum contains three inositol monophosphatase activities with different substrate specificities and sensitivities to lithium.
Topics: Animals; Chromatography, Ion Exchange; Dictyostelium; Inositol; Lithium; Phosphoric Monoester Hydrolases; Substrate Specificity | 1996 |
Lithium stimulation of rat pancreatic beta-cell replication is mediated through pertussis toxin-sensitive GTP-binding proteins and occurs independently of Ca2+ influx, cAMP, or protein kinase C activation.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Cyclic AMP; DNA; Enzyme Activation; GTP-Binding Proteins; Inositol; Insulin; Insulin Secretion; Islets of Langerhans; Lithium; Mitogens; Pertussis Toxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Virulence Factors, Bordetella | 1996 |
Effects of lithium and myoinositol on the rat bisected vas deferens.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol; Lithium; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Rats, Wistar; Vas Deferens | 1995 |
Oxidative stress in acidic conditions increases the production of inositol phosphates in chick retinal cells in culture.
Topics: Animals; Ascorbic Acid; Calcium; Carbachol; Cells, Cultured; Chick Embryo; Ferrous Compounds; Glutamic Acid; Hydrogen-Ion Concentration; Inositol; Inositol Phosphates; Kinetics; Lithium; Muscarine; Oxidative Stress; Potassium; Retina; Tritium | 1996 |
Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: potentiation by muscarinic receptor activation.
Topics: Animals; Carbachol; Cell Division; Cells, Cultured; Down-Regulation; Hippocampus; Inositol; Intracellular Signaling Peptides and Proteins; Lithium; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Protein Kinase C; Proteins; Receptors, Muscarinic | 1996 |
Site-specific regulation of organic osmolytes along the rat nephron.
Topics: Animals; Diuretics; Drinking; Furosemide; Inositol; Lithium; Male; Nephrons; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sorbitol; Urine; Water-Electrolyte Balance | 1996 |
Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol.
Topics: Animals; Frontal Lobe; Hippocampus; Inositol; Isoenzymes; Lithium; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1996 |
Evidence for a single pool of myo-inositol in hormone-responsive WRK-1 cells.
Topics: Animals; Inositol; Inositol Phosphates; Lithium; Phosphatidylinositols; Rats; Tumor Cells, Cultured; Vasopressins | 1995 |
Investigation of the role of inositol and the phosphatidylinositol signal transduction system in mouse embryonic stem cells.
Topics: Animals; Cell Division; Cell Line; Glucosamine; Inositol; Inositol Phosphates; Lithium; Mice; Phosphatidylinositols; Signal Transduction; Stem Cells | 1996 |
Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA). Short communication.
Topics: Animals; CHO Cells; Cricetinae; Cytidine Monophosphate; Glycerophospholipids; In Vitro Techniques; Inositol; Isomerism; Lithium; Phosphatidic Acids; Rats; Receptors, Muscarinic; Transfection | 1996 |
Activation of the Wnt signaling pathway: a molecular mechanism for lithium action.
Topics: Animals; beta Catenin; Calcium-Calmodulin-Dependent Protein Kinases; Cytoskeletal Proteins; Drosophila Proteins; Embryonic Induction; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Inositol; Larva; Lithium; Oocytes; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcription Factor AP-1; Wnt1 Protein; Xenopus; Xenopus Proteins | 1997 |
Regulation of inositol monophosphatase in Saccharomyces cerevisiae.
Topics: Enzyme Inhibitors; Ethanol; Glucose; Glycerol; Inositol; Lithium; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Saccharomyces cerevisiae; Second Messenger Systems; Signal Transduction | 1997 |
Lithium-induced inositol depletion in rat brain after chronic treatment is restricted to the hypothalamus.
Topics: Animals; Brain; Hypothalamus; Inositol; Lithium; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Chronic treatment with lithium and pretreatment with excess inositol reduce inositol pool size in astrocytes by different mechanisms.
Topics: Animals; Antidepressive Agents; Astrocytes; Cells, Cultured; Inositol; Kinetics; Lithium; Mice; Time Factors; Tritium | 1998 |
Disruption by lithium of phosphoinositide signalling in cerebellar granule cells in primary culture.
Topics: Animals; Carbachol; Cells, Cultured; Cerebellum; Diglycerides; Extracellular Space; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Muscarinic Agonists; Neurons; Phosphatidylinositols; Potassium Chloride; Rats; Signal Transduction | 1998 |
Augmentation of lithium's behavioral effect by inositol uptake inhibitors.
Topics: Animals; Depsipeptides; Drug Synergism; Fucose; Injections, Intraventricular; Inositol; Lithium; Male; Peptides, Cyclic; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Lithium enhancement of the prolactin response to 5-hydroxytryptophan is not reversible by inositol.
Topics: 5-Hydroxytryptophan; Animals; Antipsychotic Agents; Drug Synergism; Inositol; Lithium; Male; Prolactin; Rats; Rats, Sprague-Dawley | 1998 |
Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine.
Topics: 5'-Nucleotidase; Animals; Anticonvulsants; Carbamazepine; Cells, Cultured; Cerebellum; Inositol; Lithium; Neuroprotective Agents; Phenytoin; Phosphatidylinositol 3-Kinases; Potassium; Rats; Rats, Sprague-Dawley | 1998 |
myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity.
Topics: Acid Phosphatase; Animals; Brain; Cattle; Chromatography; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Inositol; Lithium; Metals; Phosphoric Monoester Hydrolases; Precipitin Tests; Protein Tyrosine Phosphatases; Second Messenger Systems; Substrate Specificity; Vanadates; Zinc | 1998 |
Pilocarpine toxicity in retinal ganglion cells.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Inositol; Lithium; Pilocarpine; Rats; Rats, Long-Evans; Retinal Ganglion Cells | 1999 |
The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair.
Topics: Amino Acid Sequence; Calcium; Cloning, Molecular; Gene Deletion; Genes, Fungal; Inositol; Lithium; Molecular Sequence Data; Phosphoric Monoester Hydrolases; Plasmids; Recombinant Proteins; Saccharomyces cerevisiae; Sodium | 1999 |
The effects of lithium on vascular development in the chick area vasculosa.
Topics: Animals; Antidepressive Agents; Blood Vessels; Chick Embryo; Culture Techniques; Dose-Response Relationship, Drug; Endothelium, Vascular; Inositol; Lithium; Time Factors | 1999 |
Inhibition of the high affinity myo-inositol transport system: a common mechanism of action of antibipolar drugs?
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Antimanic Agents; Astrocytes; Biological Transport; Brain; Carbamazepine; Carrier Proteins; Heat-Shock Proteins; Humans; Inositol; Lithium; Membrane Proteins; Rats; Rats, Wistar; RNA, Messenger; Symporters; Time Factors; Tumor Cells, Cultured; Valproic Acid | 1999 |
Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness.
Topics: Adult; Analysis of Variance; Bipolar Disorder; Depression, Chemical; Female; Frontal Lobe; Humans; Inositol; Lithium; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Parietal Lobe; Temporal Lobe; Time Factors; Treatment Outcome | 1999 |
Xoom: a novel oocyte membrane protein maternally expressed and involved in the gastrulation movement of Xenopus embryos.
Topics: Amino Acid Sequence; Animals; Base Sequence; Embryo, Nonmammalian; Gastrula; Inositol; Larva; Lithium; Membrane Proteins; Molecular Sequence Data; Oocytes; Organ Specificity; RNA, Messenger; Signal Transduction; Transcription, Genetic; Ultraviolet Rays; Xenopus laevis; Xenopus Proteins | 1999 |
Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy.
Topics: Animals; Chronic Disease; Cold Temperature; Drug Interactions; Hot Temperature; Hyperalgesia; Injections, Spinal; Inositol; Lithium; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Disease Models, Animal; Down Syndrome; Female; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Mutant Strains; Protons | 2000 |
Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.
Topics: Animals; Axons; Biological Factors; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Cerebellar Cortex; Coculture Techniques; Culture Media, Conditioned; Culture Media, Serum-Free; Dendrites; Glycogen Synthase Kinase 3; Glycoproteins; Growth Cones; Inositol; Intracellular Signaling Peptides and Proteins; Lithium; Mice; Mice, Knockout; Microtubule-Associated Proteins; Nerve Fibers; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Phosphorylation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Signal Transduction; Synapses; Synapsins; Transfection; Wnt Proteins | 2000 |
Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate.
Topics: Amino Acid Sequence; Animals; Carbon; Cattle; Escherichia coli; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Genotype; Humans; Inositol; Lithium; Molecular Sequence Data; Open Reading Frames; Phosphoric Monoester Hydrolases; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Valproic Acid; Xenopus laevis | 2000 |
Regulation of Myo-inositol homeostasis in differentiated human NT2-N neurons.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Biological Transport; Calcium; Cell Differentiation; Cyclic GMP; Enzyme Activation; Humans; Hypotonic Solutions; Inositol; Ionomycin; Lithium; Neurons; Oxotremorine; Protein Kinase C; Second Messenger Systems; Signal Transduction; Teratocarcinoma; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured | 2000 |
Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO.
Topics: Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Blotting, Northern; Blotting, Western; Brain; Carrier Proteins; Cell Size; Chickens; Cloning, Molecular; Female; Ganglia, Parasympathetic; Genotype; Heart Rate, Fetal; Humans; Inositol; Lithium; Membrane Proteins; Molecular Sequence Data; Phenotype; Pregnancy | 2000 |
Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis.
Topics: Basic Helix-Loop-Helix Transcription Factors; DNA-Binding Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Inositol; Lithium; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Valproic Acid | 2001 |
Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis.
Topics: Cations, Divalent; Enzyme Activation; Enzyme Inhibitors; Genome, Bacterial; Inositol; Kinetics; Lithium; Mycobacterium smegmatis; Mycobacterium tuberculosis; Phosphoric Monoester Hydrolases; Sodium | 2002 |
Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase.
Topics: Anticonvulsants; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Inositol; Isomerism; Lithium; Myo-Inositol-1-Phosphate Synthase; Saccharomyces cerevisiae; Valproic Acid | 2002 |
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
Topics: Amino Acid Sequence; Cloning, Molecular; Dose-Response Relationship, Drug; Enzyme Activation; Escherichia coli; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hydrolysis; Inhibitory Concentration 50; Inositol; Kinetics; Lithium; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Mycobacterium tuberculosis; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 2002 |
Does inositol signalling have a role in disease susceptibility and drug treatment of bipolar disorder?
Topics: Bipolar Disorder; Disease Susceptibility; Humans; Inositol; Lithium; Phosphoric Monoester Hydrolases; Signal Transduction | 2002 |
Chronic lithium and sodium valproate both decrease the concentration of myoinositol and increase the concentration of inositol monophosphates in rat brain.
Topics: Animals; Anticonvulsants; Brain Chemistry; Central Nervous System Stimulants; Creatine; Dextroamphetamine; Glucose-6-Phosphate; Glycine; Inositol; Inositol Phosphates; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Valproic Acid | 2003 |
Drug research: the ups and downs of lithium.
Topics: Affect; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Glycogen Synthase Kinase 3; Humans; Inositol; Lithium; Male; Neurons; Second Messenger Systems; Stem Cells | 2003 |
Genomic organization and regulation of the LeIMP-1 and LeIMP-2 genes encoding myo-inositol monophosphatase in tomato.
Topics: Animals; DNA, Plant; Exons; Genes, Plant; Glucuronidase; Inositol; Introns; Isoenzymes; Lithium; Molecular Sequence Data; Phosphoric Monoester Hydrolases; Phylogeny; Plants, Genetically Modified; Promoter Regions, Genetic; Recombinant Fusion Proteins; Sequence Analysis, DNA; Solanum lycopersicum | 2004 |
Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain.
Topics: Animals; Brain; In Vitro Techniques; Inositol; Lithium; Mice; Mice, Knockout; Mood Disorders; Phosphatidylinositols; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Symporters; Tissue Extracts | 2004 |
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.
Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid | 2004 |
Lithium induces autophagy by inhibiting inositol monophosphatase.
Topics: alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Humans; Huntingtin Protein; Inositol; Lithium; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Phosphoric Monoester Hydrolases; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases | 2005 |
Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis.
Topics: Amino Acid Sequence; Base Sequence; DNA Primers; Glycolysis; Inositol; Lithium; Molecular Sequence Data; Mutation; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Triose-Phosphate Isomerase; Valproic Acid | 2005 |
Lithium and inositol: effects on brain water homeostasis in the rat.
Topics: Animals; Cerebellum; Frontal Lobe; Hippocampus; Homeostasis; Inositol; Lithium; Male; Rats; Rats, Sprague-Dawley; Water | 2006 |
SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Brain; Genotype; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Inositol; Lithium; Mice; Symporters | 2006 |
A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder.
Topics: Affect; Animals; Bipolar Disorder; Brain; Gene Expression Profiling; Inositol; Lithium; Lithium Carbonate; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neurobiology; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Software | 2007 |
Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation.
Topics: Adult Stem Cells; Animals; Antipsychotic Agents; beta Catenin; Bromodeoxyuridine; Cell Differentiation; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Green Fluorescent Proteins; Hippocampus; Humans; Inositol; Lithium; Nerve Tissue Proteins; Neurons; Rats; Rats, Inbred F344; Signal Transduction; Transfection; Wnt Proteins | 2008 |
A safe lithium mimetic for bipolar disorder.
Topics: Animals; Azoles; Behavior, Animal; Bipolar Disorder; Blood-Brain Barrier; Enzyme Inhibitors; Humans; Inositol; Isoindoles; Lithium; Male; Mice; Mice, Inbred C57BL; Molecular Mimicry; Organoselenium Compounds; Phosphoric Monoester Hydrolases | 2013 |
Inositol-related gene knockouts mimic lithium's effect on mitochondrial function.
Topics: Animals; Gene Knockout Techniques; Inositol; Lithium; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mitochondria | 2014 |
Acute intracerebroventricular inositol does not reverse the effect of chronic lithium treatment in the forced swim test.
Topics: Animals; Brain; Drug Interactions; Injections, Intraventricular; Inositol; Lithium; Male; Mice; Mice, Inbred ICR; Stress, Psychological; Swimming | 2013 |
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bipolar Disorder; Brain; Brain Diseases; Circadian Rhythm; Disease Models, Animal; Ethylnitrosourea; Female; Gene Library; Genotype; Homozygote; Humans; Inositol; Lithium; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; Mutation; Mutation, Missense; Phosphoric Monoester Hydrolases; Recombinant Proteins; Sequence Homology, Amino Acid; Time Factors | 2014 |
Lithium hydride as an efficient reagent for the preparation of 1,2-anhydro inositols: Does the reaction proceed through 'axial rich' conformation?
Topics: Epoxy Compounds; Indicators and Reagents; Inositol; Lithium; Models, Molecular; Molecular Structure; Stereoisomerism; X-Ray Diffraction | 2018 |
Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal
Topics: Aspartic Acid; Bipolar Disorder; Brain; Choline; Creatine; Gyrus Cinguli; Humans; Inositol; Lithium; Proton Magnetic Resonance Spectroscopy | 2021 |
Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase.
Topics: AMP-Activated Protein Kinases; Animals; Fibroblasts; Glucose; Humans; Inositol; Lithium; Mammals; Mice; Phosphatidic Acids; Phospholipase D; Phosphotransferases (Phosphate Group Acceptor); Valproic Acid | 2022 |
Safety of inositol supplementation in patients taking lithium or valproic acid: a pilot clinical study.
Topics: Adolescent; Adult; Dietary Supplements; Glucose; Humans; Inositol; Insulin; Lactalbumin; Lithium; Pilot Projects; Quality of Life; Thyrotropin; Triglycerides; Valproic Acid | 2022 |