Compounds > indazoles
Page last updated: 2024-08-21

indazoles and serine

indazoles has been researched along with serine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (14.29)18.2507
2000's5 (35.71)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aharony, D; Fedyna, JS; Krell, RD; Redkar-Brown, D; Snyder, DW1
Abram, TS; Cuthbert, NJ; Gardiner, PJ1
Bäck, M; Cotgreave, IA; Dahlén, SE; Kumlin, M1
Han, X; Hua, Y; Jiang, J; Lu, YM; Luo, CX; Zhou, QG; Zhu, DY; Zhu, XJ1
Giranda, VL; Han, EK; Hunter, T; Leverson, JD; Luo, Y; McGonigal, T; Shah, OJ; Woods, KW1
Hatano, N; Ihara, H; Kambe, T; Kume, K; Miyamoto, Y; Song, T; Sugimoto, K; Tokuda, M; Watanabe, Y; Yamaguchi, F; Yamamoto, H1
Acierno, R; Amelio, D; Gattuso, A; Guerrieri, A; Mannarino, C; Tota, B1
Belvin, M; Boggs, J; Burton, B; Chan, E; Chan, J; Choo, E; Gancia, E; Heald, RA; Jackson, P; Jones, M; Merchant, M; Newman, R; Price, S; Rudewicz, P; Savy, P; Ultsch, M; Wiesmann, C; Yue, Q1
Alessi, DR; Najafov, A; Shpiro, N1
Aggarwal, A; Ajamie, RT; Carballares, S; Cronier, DM; de Dios, A; Donoho, GP; Du, J; Fales, KR; Foreman, RT; Gaynor, RB; Halstead, BW; Iversen, PW; Kreklau, EL; Lallena, MJ; Li, S; Lin, AB; Meier, TI; Qian, Y; Sissons, SE; Starling, JJ; Torrres, R; Wishart, GN; Wu, S; Ye, XS; Yin, T; Zeckner, D1
Busija, DW; Dutta, S; Gordon, AO; Grovenburg, SM; Katakam, PV; Peterson, NR; Rutkai, I; Sure, VN1
Balogh, GT; Ferenczy, GG; Ilas, J; Keserű, GM; Kovács, P; Monostory, K; Németh, K; Rácz, A; Szabó, P; Szilágyi, B; Szökő, É; Tábi, T; Vincze, I; Visy, J1
Augelli-Szafran, C; Boddu, R; Kelly, K; Liu, Z; Moukha-Chafiq, O; Wang, S; West, AB1
Koizumi, K; Nabeta, R; Nakamura, Y; Oka, JI; Sasaki-Hamada, S1

Other Studies

14 other study(ies) available for indazoles and serine

ArticleYear
Pharmacologic characterization of the contractile activity of peptide leukotrienes in guinea-pig pulmonary artery.
    Prostaglandins, 1990, Volume: 39, Issue:5

    Topics: Acetophenones; Animals; Borates; Drug Synergism; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Pulmonary Artery; Receptors, Immunologic; Receptors, Leukotriene; Serine; SRS-A; Tetrazoles

1990
Evidence for two leukotriene receptor types in the guinea-pig isolated ileum.
    European journal of pharmacology, 1990, Jul-03, Volume: 182, Issue:2

    Topics: Animals; Borates; Chromones; Cyclooxygenase Inhibitors; Cysteine; Dicarboxylic Acids; Guinea Pigs; Ileum; In Vitro Techniques; Indazoles; Indomethacin; Leukotriene E4; Male; Receptors, Immunologic; Receptors, Leukotriene; Serine; SRS-A; Stereoisomerism

1990
An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea.
    British journal of pharmacology, 2001, Volume: 133, Issue:7

    Topics: Animals; Borates; Cysteine; Dicarboxylic Acids; Dose-Response Relationship, Drug; Glutathione; Guinea Pigs; In Vitro Techniques; Indazoles; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Male; Membrane Proteins; Muscle Contraction; Propionates; Quinolines; Receptors, Leukotriene; Serine; SRS-A; Trachea

2001
Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation.
    Neuroscience, 2006, Aug-25, Volume: 141, Issue:2

    Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Dizocilpine Maleate; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type I; Phosphorylation; Serine

2006
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.
    Oncogene, 2007, Aug-16, Volume: 26, Issue:38

    Topics: Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Indazoles; Indoles; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Serine; Time Factors; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins

2007
Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.
    The Biochemical journal, 2008, Jun-01, Volume: 412, Issue:2

    Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Cysteine; Enzyme Activation; Hippocampus; Hydrazines; Indazoles; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Protein Kinase Inhibitors; Rats; S-Nitroso-N-Acetylpenicillamine; Serine; Sulfonamides; Thyrotropin-Releasing Hormone

2008
Nitric oxide modulates the frog heart ventricle morphodynamics.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2008, Volume: 151, Issue:1

    Topics: Animals; Anura; Arginine; Cyclic GMP; Female; Heart Ventricles; In Vitro Techniques; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perfusion; Serine; Software; Ventricular Function

2008
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Benzofurans; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Female; Hydrogen Bonding; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Rats; Serine; Structure-Activity Relationship; Transplantation, Heterologous

2012
Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
    The Biochemical journal, 2012, Dec-01, Volume: 448, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Enzyme Activation; HEK293 Cells; Humans; Indazoles; Mechanistic Target of Rapamycin Complex 2; Mice; Molecular Sequence Data; Multiprotein Complexes; Mutation; Neoplasms; Phosphatidylinositol Phosphates; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Recombinant Proteins; Ribosomal Protein S6 Kinases; Serine; TOR Serine-Threonine Kinases

2012
A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclohexylamines; Humans; Indazoles; Leukemia; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Serine

2014
Depolarization of mitochondria in neurons promotes activation of nitric oxide synthase and generation of nitric oxide.
    American journal of physiology. Heart and circulatory physiology, 2016, 05-01, Volume: 310, Issue:9

    Topics: Animals; Benzopyrans; Cells, Cultured; Cerebral Arteries; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indazoles; Male; Membrane Potential, Mitochondrial; Mitochondria; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Paracrine Communication; Phosphorylation; Potassium Channels; Primary Cell Culture; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine; Signal Transduction; Vasodilation

2016
Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.
    Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8

    Topics: Animals; D-Amino-Acid Oxidase; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hepatocytes; Humans; Indazoles; Male; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Serine; Structure-Activity Relationship

2018
The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
    Experimental neurology, 2018, Volume: 309

    Topics: Adenosine Triphosphate; Animals; Brain; Female; Glycine; Humans; Indazoles; Kidney; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lung; Lysosomes; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Serine

2018
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like Peptide 2; Indazoles; Male; Methylene Blue; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sildenafil Citrate; Swimming

2019