indazoles and mk 2206
indazoles has been researched along with mk 2206 in 8 studies
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bressanin, D; Buontempo, F; Chiarini, F; Evangelisti, C; Martelli, AM; McCubrey, JA; Melchionda, F; Pagliaro, P; Pession, A; Ricci, F; Tabellini, G; Tazzari, PL | 1 |
| Chen, S; Cohen-Sola, KA; Goydos, JS; Jeong, BS; Koo, J; Li, J; Lin, Y; Mehnert, JM; Shin, SS; Wen, Y | 1 |
| Erlichman, C; Flatten, KS; Gálvez-Peralta, M; Kaufmann, SH; Loegering, DA; Peterson, KL; Schneider, PA | 1 |
| Avril, N; Hagemann, T; Hudson, CD; Mather, SJ | 1 |
| Fukutake, S; Kurosu, T; Miura, O; Nagao, T; Nogami, A; Okada, K; Oshikawa, G; Umezawa, Y | 1 |
| Akutagawa, J; Braun, BS; Chang, T; Cottonham, CL; Dail, M; Epstein, I; Friedman, LS; Huang, TQ; Quirindongo-Crespo, M; Sampath, D; Slusher, BS | 1 |
| Chen, Y; Han, Z; Hou, X; Qian, Z; Wang, Y; Wu, T; Yuan, J; Zhu, D; Zou, J | 1 |
| Chorner, PM; Moorehead, RA | 1 |
Other Studies
8 other study(ies) available for indazoles and mk 2206
| Article | Year |
|---|---|
Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels.
Topics: Adult; Caspase 3; Cell Line, Tumor; Child; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Indazoles; Molecular Targeted Therapy; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinolines; Signal Transduction; Sulfonamides; T-Lymphocytes; TOR Serine-Threonine Kinases | 2012 |
Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression.
Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Inhibitor of Apoptosis Proteins; Interleukin-8; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Metabotropic Glutamate; Riluzole; Signal Transduction; Sirolimus; Skin Neoplasms; Survivin; Tumor Burden; Vascular Endothelial Growth Factor A | 2014 |
Context-dependent antagonism between Akt inhibitors and topoisomerase poisons.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; HCT116 Cells; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Indoles; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Poisons; Proto-Oncogene Proteins c-akt; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2014 |
Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Axitinib; Cell Membrane; Cell Proliferation; Cell Shape; Cell Survival; Clone Cells; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Glucose; Glucose Transporter Type 1; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Indazoles; Mice; Mitosis; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt | 2014 |
FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Caspase 9; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Eukaryotic Initiation Factors; fms-Like Tyrosine Kinase 3; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Leukemia, Myeloid, Acute; Mice; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Pimozide; Proto-Oncogene Proteins c-akt; STAT5 Transcription Factor; Sulfonamides; TOR Serine-Threonine Kinases | 2015 |
Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras.
Topics: Animals; Heterocyclic Compounds, 3-Ring; Indazoles; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; MAP Kinase Signaling System; Mice; Myelodysplastic Syndromes; Myeloproliferative Disorders; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; ras Proteins; Signal Transduction; Sulfonamides | 2016 |
CLOCK-BMAL1 regulate the cardiac L-type calcium channel subunit CACNA1C through PI3K-Akt signaling pathway.
Topics: Action Potentials; Animals; ARNTL Transcription Factors; Calcium Channels, L-Type; Cells, Cultured; Circadian Rhythm; CLOCK Proteins; Guinea Pigs; Heterocyclic Compounds, 3-Ring; Indazoles; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction | 2016 |
A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 2; Down-Regulation; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Lung Neoplasms; Pyridines | 2018 |