Compounds > indazoles
Page last updated: 2024-08-21

indazoles and mk 2206

indazoles has been researched along with mk 2206 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bressanin, D; Buontempo, F; Chiarini, F; Evangelisti, C; Martelli, AM; McCubrey, JA; Melchionda, F; Pagliaro, P; Pession, A; Ricci, F; Tabellini, G; Tazzari, PL1
Chen, S; Cohen-Sola, KA; Goydos, JS; Jeong, BS; Koo, J; Li, J; Lin, Y; Mehnert, JM; Shin, SS; Wen, Y1
Erlichman, C; Flatten, KS; Gálvez-Peralta, M; Kaufmann, SH; Loegering, DA; Peterson, KL; Schneider, PA1
Avril, N; Hagemann, T; Hudson, CD; Mather, SJ1
Fukutake, S; Kurosu, T; Miura, O; Nagao, T; Nogami, A; Okada, K; Oshikawa, G; Umezawa, Y1
Akutagawa, J; Braun, BS; Chang, T; Cottonham, CL; Dail, M; Epstein, I; Friedman, LS; Huang, TQ; Quirindongo-Crespo, M; Sampath, D; Slusher, BS1
Chen, Y; Han, Z; Hou, X; Qian, Z; Wang, Y; Wu, T; Yuan, J; Zhu, D; Zou, J1
Chorner, PM; Moorehead, RA1

Other Studies

8 other study(ies) available for indazoles and mk 2206

ArticleYear
Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels.
    Oncotarget, 2012, Volume: 3, Issue:8

    Topics: Adult; Caspase 3; Cell Line, Tumor; Child; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Indazoles; Molecular Targeted Therapy; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinolines; Signal Transduction; Sulfonamides; T-Lymphocytes; TOR Serine-Threonine Kinases

2012
Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression.
    Cancer research, 2014, May-01, Volume: 74, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Inhibitor of Apoptosis Proteins; Interleukin-8; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Metabotropic Glutamate; Riluzole; Signal Transduction; Sirolimus; Skin Neoplasms; Survivin; Tumor Burden; Vascular Endothelial Growth Factor A

2014
Context-dependent antagonism between Akt inhibitors and topoisomerase poisons.
    Molecular pharmacology, 2014, Volume: 85, Issue:5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; HCT116 Cells; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Indoles; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Poisons; Proto-Oncogene Proteins c-akt; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2014
Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma.
    Cell death & disease, 2014, Apr-10, Volume: 5

    Topics: Adenocarcinoma; Animals; Axitinib; Cell Membrane; Cell Proliferation; Cell Shape; Cell Survival; Clone Cells; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Glucose; Glucose Transporter Type 1; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Indazoles; Mice; Mitosis; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt

2014
FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia.
    Oncotarget, 2015, Apr-20, Volume: 6, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Caspase 9; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Eukaryotic Initiation Factors; fms-Like Tyrosine Kinase 3; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Leukemia, Myeloid, Acute; Mice; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Pimozide; Proto-Oncogene Proteins c-akt; STAT5 Transcription Factor; Sulfonamides; TOR Serine-Threonine Kinases

2015
Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras.
    Leukemia, 2016, Volume: 30, Issue:6

    Topics: Animals; Heterocyclic Compounds, 3-Ring; Indazoles; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; MAP Kinase Signaling System; Mice; Myelodysplastic Syndromes; Myeloproliferative Disorders; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; ras Proteins; Signal Transduction; Sulfonamides

2016
CLOCK-BMAL1 regulate the cardiac L-type calcium channel subunit CACNA1C through PI3K-Akt signaling pathway.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:9

    Topics: Action Potentials; Animals; ARNTL Transcription Factors; Calcium Channels, L-Type; Cells, Cultured; Circadian Rhythm; CLOCK Proteins; Guinea Pigs; Heterocyclic Compounds, 3-Ring; Indazoles; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction

2016
A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206.
    PloS one, 2018, Volume: 13, Issue:2

    Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 2; Down-Regulation; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Lung Neoplasms; Pyridines

2018