Compounds > indazoles
Page last updated: 2024-08-21

indazoles and kw 2449

indazoles has been researched along with kw 2449 in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's8 (72.73)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Abe, A; Akinaga, S; Akiyama, T; Ishii, K; Ishikawa, Y; Kanda, Y; Kiyoi, H; Maeda, H; Minami, Y; Mori, Y; Naoe, T; Ozeki, K; Sato, Y; Shimizu, M; Shiotsu, Y; Tanizaki, R; Umehara, H1
Levis, M; Murphy, KM; Pratz, KW; Rajkhowa, T; Sato, T; Stine, A1
Kiyoi, H1
Burnett, A; Galkin, S; Knapper, S; Levis, M; Sato, T; Small, D; Smith, BD; White, P; Yang, X1
Attkisson, E; Dai, Y; Grant, S; Jordan, N; Kolluri, N; Kramer, L; Muschen, M; Nguyen, N; Nguyen, T1
Coumar, MS; Sarvagalla, S1
Fuse, E; Hosogi, J; Kuwabara, T; Maeda, H; Ohashi, R; Tashiro, S; Yamamoto, Y1
Fujita, K; Hosogi, J; Imamura, T; Kuwabara, T; Maeda, H; Ohashi, R; Ushiki, J; Yamamoto, Y1
Liu, Y; Lyu, J; Miao, Z; Poon, TCW; Shim, JS; Tan, K; Wu, C; Yang, EJ; Zhang, B1
Abbaspour, A; Afraei, S; Ahmadabad, HN; Azizi, G; Bagheri, Y; Di Fiore, MM; Goudarzvand, M; Hossein-Khannazer, N; Kamali, AN; Miladi, H; Panahi, Y; Tahmasebi, S; Yazdani, R1
Cai, Z; Chen, G; Chen, X; Qin, X; Ren, W; Rui, C; Shi, SN; Wang, HY; Yu, J; Zhuang, C1

Reviews

2 review(s) available for indazoles and kw 2449

ArticleYear
[FLT3 kinase inhibitors for the treatment of acute leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2010, Volume: 51, Issue:6

    Topics: Acute Disease; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Indazoles; Leukemia; Mutation; Piperazines; Quinazolines; Signal Transduction; Staurosporine

2010
Structural Biology Insight for the Design of Sub-type Selective Aurora Kinase Inhibitors.
    Current cancer drug targets, 2015, Volume: 15, Issue:5

    Topics: Animals; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Binding Sites; Humans; Indazoles; Piperazines; Protein Kinase Inhibitors; Protein Structure, Secondary; Pyrazoles

2015

Other Studies

9 other study(ies) available for indazoles and kw 2449

ArticleYear
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.
    Blood, 2009, Aug-20, Volume: 114, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; fms-Like Tyrosine Kinase 3; Fusion Proteins, bcr-abl; HL-60 Cells; Humans; Indazoles; Isoleucine; K562 Cells; Leukemia; Male; Mice; Mice, Inbred C3H; Mice, SCID; Mutation, Missense; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcr; Threonine; Translocation, Genetic

2009
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.
    Blood, 2010, Feb-18, Volume: 115, Issue:7

    Topics: Alleles; Antineoplastic Agents; Benzenesulfonates; Benzothiazoles; Carbazoles; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Furans; Humans; Indazoles; Indoles; Leukemia, Myeloid, Acute; Mutation; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Pyridines; Pyrroles; Sorafenib; Staurosporine; Sunitinib

2010
FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo.
    Blood, 2011, Mar-24, Volume: 117, Issue:12

    Topics: Antineoplastic Agents; Benzenesulfonates; Carbazoles; Cells, Cultured; Drug Antagonism; fms-Like Tyrosine Kinase 3; Furans; Humans; Indazoles; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Membrane Proteins; Multicenter Studies as Topic; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Sorafenib; Staurosporine; Treatment Outcome

2011
HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, May-15, Volume: 17, Issue:10

    Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Imatinib Mesylate; Indazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Mice, SCID; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Xenograft Model Antitumor Assays

2011
Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
    Drug metabolism and pharmacokinetics, 2017, Volume: 32, Issue:5

    Topics: Aldehyde Oxidase; Animals; Cytochrome P-450 Enzyme System; Dogs; Hepatocytes; Humans; Imines; Indazoles; Ions; Macaca fascicularis; Microsomes, Liver; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Piperazine; Piperazines; Rats

2017
An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
    Biopharmaceutics & drug disposition, 2018, Volume: 39, Issue:3

    Topics: Aldehyde Oxidase; Animals; Carbon Isotopes; Humans; Indazoles; Macaca fascicularis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Piperazines; Protein Binding; Proteins; Radioligand Assay; Sodium Cyanide

2018
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A.
    Cancer letters, 2018, 11-01, Volume: 436

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aurora Kinase A; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; fms-Like Tyrosine Kinase 3; HCT116 Cells; Humans; Indazoles; Mice, Nude; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrazoles; Pyrimidines; Signal Transduction; Xenograft Model Antitumor Assays

2018
Anti-Inflammatory Effect of KW-2449 on Autoimmune Encephalomyelitis: An Experimental Study on Mice.
    Endocrine, metabolic & immune disorders drug targets, 2021, Volume: 21, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Brain; Chemotaxis, Leukocyte; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Indazoles; Inflammation Mediators; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Piperazines

2021
The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis.
    Biochemical pharmacology, 2021, Volume: 188

    Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Dose-Response Relationship, Drug; Drug Delivery Systems; HT29 Cells; Humans; Indazoles; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Necroptosis; Piperazines; Protein Kinase Inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases

2021