Page last updated: 2024-08-21

indazoles and heme

indazoles has been researched along with heme in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (19.05)	18.2507
2000's	11 (52.38)	29.6817
2010's	6 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Friebe, A; Koesling, D	1
Alderton, WK; Boyhan, A; Lowe, PN	1
Behrends, S; Harteneck, C; Koesling, D; Russwurm, M	1
Apeler, H; Becker, EM; Gerzer, R; Hoenicka, M; Schröder, H; Sirichoke, T; Stasch, JP	1
Karaczyn, A; Keppler, BK; Kozłowski, H; Trynda-Lemiesz, L	1
Alonso-Alija, C; Apeler, H; Becker, EM; Dembowsky, K; Feurer, A; Gerzer, R; Minuth, T; Perzborn, E; Pleiss, U; Schramm, M; Schröder, H; Schroeder, W; Stahl, E; Stasch, JP; Steinke, W; Straub, A	1
Lee, YC; Martin, E; Murad, F	1
Counts Gerber, N; Kosarikov, DN; Lee, JM; Uversky, VN	1
Behrends, S; Koglin, M	1
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP	1
Kitagawa, T; Li, Z; Ohta, T; Pal, B; Takenaka, S; Tsuyama, S	1
Czarnecki, K; Jayaraman, V; Kincaid, J; Martin, E; Murad, F	1
Derbyshire, ER; Marletta, MA; Martin, NI	1
Hobbs, AJ; Stasch, JP	1
Acuña-Castroviejo, D; Claramunt, RM; Elguero, J; Escames, G; López, C; Pérez-Medina, C; Pérez-Torralba, M	1
Derbyshire, ER; Ibrahim, M; Marletta, MA; Spiro, TG	1
Baskaran, P; Beuve, A; Heckler, EJ; van den Akker, F	1
Bytzek, AK; Dömötör, O; Enyedy, EA; Hartinger, CG; Keppler, BK; Kiss, T	1
Campbell, E; David, CL; Fritz, BG; Gage, MJ; Garcin, ED; Hausrath, AC; Issaian, A; Montfort, WR; Purohit, R; Rassouli-Taylor, L; The, J; Weichsel, A	1
He, T; He, Y; Li, G; Qian, S; Wang, W; Wang, Z; Yang, L; Zhang, M	1
Akai, S; Katsuda, M; Kawano, Y; Maeda, S; Masuda, S; Meguro, K; Saiki, T; Takada, K; Takagi, A; Tsujino, H; Uno, T; Yamashita, T	1

Reviews

1 review(s) available for indazoles and heme

Article	Year
NO-independent, haem-dependent soluble guanylate cyclase stimulators. Handbook of experimental pharmacology, 2009, Issue:191 Topics: Acrylamides; Animals; Cardiovascular Diseases; Clinical Trials as Topic; Enzyme Activators; Guanylate Cyclase; Heme; Humans; Indazoles; Nitric Oxide; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase	2009

Other Studies

20 other study(ies) available for indazoles and heme

Article	Year
Mechanism of YC-1-induced activation of soluble guanylyl cyclase. Molecular pharmacology, 1998, Volume: 53, Issue:1 Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Nitrogen Oxides; Photosensitizing Agents; Platelet Aggregation Inhibitors; Protoporphyrins; Solubility	1998
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay. The Biochemical journal, 1998, May-15, Volume: 332 ( Pt 1) Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins	1998
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. The Biochemical journal, 1998, Oct-01, Volume: 335 ( Pt 1) Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera	1998
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide. Journal of molecular medicine (Berlin, Germany), 1999, Volume: 77, Issue:1 Topics: Animals; Baculoviridae; Carbon Monoxide; Cell Line; Copper; Enzyme Activation; Guanylate Cyclase; Heme; Hydrazines; Indazoles; Mass Spectrometry; Nitric Oxide; Nitrogen Oxides; Recombinant Proteins; Spodoptera	1999
Studies on the interactions between human serum albumin and trans-indazolium (bisindazole) tetrachlororuthenate(III). Journal of inorganic biochemistry, 2000, Volume: 78, Issue:4 Topics: Bilirubin; Chromatography; Circular Dichroism; Dextrans; Heme; Humans; Indazoles; Models, Chemical; Organometallic Compounds; Protein Binding; Protein Conformation; Serum Albumin; Spectrometry, Fluorescence; Spectrophotometry; Ultraviolet Rays; Warfarin	2000
NO-independent regulatory site on soluble guanylate cyclase. Nature, 2001, Mar-08, Volume: 410, Issue:6825 Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cyclic N-Oxides; Cysteine; Disease Models, Animal; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Imidazoles; In Vitro Techniques; Indazoles; Molecular Sequence Data; Nitric Oxide; Photoaffinity Labels; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Rats; Solubility	2001
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proceedings of the National Academy of Sciences of the United States of America, 2001, Nov-06, Volume: 98, Issue:23 Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility	2001
Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase. Journal of inorganic biochemistry, 2001, Dec-15, Volume: 87, Issue:4 Topics: Acrylamide; Circular Dichroism; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Models, Chemical; Models, Molecular; Nitric Oxide; Nitric Oxide Donors; Protein Conformation; Protein Structure, Secondary; Spectrometry, Fluorescence; Tryptophan	2001
A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding. The Journal of biological chemistry, 2003, Apr-04, Volume: 278, Issue:14 Topics: Animals; Cattle; Cell Line; Cloning, Molecular; Enzyme Activation; Enzyme Activators; Gene Deletion; Guanylate Cyclase; Heme; Humans; Indazoles; Nitric Oxide; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Spodoptera	2003
Preparation of heme-free soluble guanylate cyclase. Protein expression and purification, 2003, Volume: 31, Issue:1 Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc	2003
Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP. Journal of inorganic biochemistry, 2004, Volume: 98, Issue:5 Topics: Animals; Cattle; Drug Synergism; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Heme; Imidazoles; In Vitro Techniques; Indazoles; Solubility; Spectrum Analysis, Raman	2004
Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase. Journal of the American Chemical Society, 2005, Apr-06, Volume: 127, Issue:13 Topics: Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Protein Conformation; Pyrazoles; Pyridines; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Structure-Activity Relationship	2005
Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic & medicinal chemistry letters, 2007, Sep-01, Volume: 17, Issue:17 Topics: Alcohols; Chemistry, Pharmaceutical; Drug Design; Electrons; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Indazoles; Kinetics; Models, Chemical; Nitric Oxide; Organophosphonates; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Temperature	2007
Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorganic & medicinal chemistry, 2009, Sep-01, Volume: 17, Issue:17 Topics: Animals; Enzyme Inhibitors; Halogenation; Heme; Indazoles; Male; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar	2009
Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. Biochemistry, 2010, May-11, Volume: 49, Issue:18 Topics: Animals; Binding Sites; Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrum Analysis, Raman	2010
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation. Biochemistry, 2011, May-24, Volume: 50, Issue:20 Topics: Alanine; Animals; Aspartic Acid; Chlorocebus aethiops; COS Cells; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase	2011
Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2013, Volume: 18, Issue:1 Topics: Antineoplastic Agents; Bilirubin; Binding, Competitive; Heme; Humans; Indazoles; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Serum Albumin; Spectrometry, Fluorescence	2013
YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry, 2014, Jan-14, Volume: 53, Issue:1 Topics: Allosteric Regulation; Animals; Carbon Monoxide; Cattle; Guanylate Cyclase; Heme; Indazoles; Manduca; Models, Molecular; Nitric Oxide; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Surface Plasmon Resonance	2014
Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties. Bioorganic & medicinal chemistry, 2016, 12-01, Volume: 24, Issue:23 Topics: Benzylamines; Binding Sites; Drug Discovery; Heme; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Indazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Molecular Docking Simulation; Structure-Activity Relationship	2016
Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity. Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19 Topics: Binding Sites; Enzyme Inhibitors; Heme; Humans; Indazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Molecular Docking Simulation; Protein Conformation	2019