indazoles and heme
indazoles has been researched along with heme in 21 studies
Research
Studies (21)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Friebe, A; Koesling, D | 1 |
| Alderton, WK; Boyhan, A; Lowe, PN | 1 |
| Behrends, S; Harteneck, C; Koesling, D; Russwurm, M | 1 |
| Apeler, H; Becker, EM; Gerzer, R; Hoenicka, M; Schröder, H; Sirichoke, T; Stasch, JP | 1 |
| Karaczyn, A; Keppler, BK; Kozłowski, H; Trynda-Lemiesz, L | 1 |
| Alonso-Alija, C; Apeler, H; Becker, EM; Dembowsky, K; Feurer, A; Gerzer, R; Minuth, T; Perzborn, E; Pleiss, U; Schramm, M; Schröder, H; Schroeder, W; Stahl, E; Stasch, JP; Steinke, W; Straub, A | 1 |
| Lee, YC; Martin, E; Murad, F | 1 |
| Counts Gerber, N; Kosarikov, DN; Lee, JM; Uversky, VN | 1 |
| Behrends, S; Koglin, M | 1 |
| Schmidt, P; Schramm, M; Schröder, H; Stasch, JP | 1 |
| Kitagawa, T; Li, Z; Ohta, T; Pal, B; Takenaka, S; Tsuyama, S | 1 |
| Czarnecki, K; Jayaraman, V; Kincaid, J; Martin, E; Murad, F | 1 |
| Derbyshire, ER; Marletta, MA; Martin, NI | 1 |
| Hobbs, AJ; Stasch, JP | 1 |
| Acuña-Castroviejo, D; Claramunt, RM; Elguero, J; Escames, G; López, C; Pérez-Medina, C; Pérez-Torralba, M | 1 |
| Derbyshire, ER; Ibrahim, M; Marletta, MA; Spiro, TG | 1 |
| Baskaran, P; Beuve, A; Heckler, EJ; van den Akker, F | 1 |
| Bytzek, AK; Dömötör, O; Enyedy, EA; Hartinger, CG; Keppler, BK; Kiss, T | 1 |
| Campbell, E; David, CL; Fritz, BG; Gage, MJ; Garcin, ED; Hausrath, AC; Issaian, A; Montfort, WR; Purohit, R; Rassouli-Taylor, L; The, J; Weichsel, A | 1 |
| He, T; He, Y; Li, G; Qian, S; Wang, W; Wang, Z; Yang, L; Zhang, M | 1 |
| Akai, S; Katsuda, M; Kawano, Y; Maeda, S; Masuda, S; Meguro, K; Saiki, T; Takada, K; Takagi, A; Tsujino, H; Uno, T; Yamashita, T | 1 |
Reviews
1 review(s) available for indazoles and heme
| Article | Year |
|---|---|
NO-independent, haem-dependent soluble guanylate cyclase stimulators.
Topics: Acrylamides; Animals; Cardiovascular Diseases; Clinical Trials as Topic; Enzyme Activators; Guanylate Cyclase; Heme; Humans; Indazoles; Nitric Oxide; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2009 |
Other Studies
20 other study(ies) available for indazoles and heme
| Article | Year |
|---|---|
Mechanism of YC-1-induced activation of soluble guanylyl cyclase.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Nitrogen Oxides; Photosensitizing Agents; Platelet Aggregation Inhibitors; Protoporphyrins; Solubility | 1998 |
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins | 1998 |
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera | 1998 |
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide.
Topics: Animals; Baculoviridae; Carbon Monoxide; Cell Line; Copper; Enzyme Activation; Guanylate Cyclase; Heme; Hydrazines; Indazoles; Mass Spectrometry; Nitric Oxide; Nitrogen Oxides; Recombinant Proteins; Spodoptera | 1999 |
Studies on the interactions between human serum albumin and trans-indazolium (bisindazole) tetrachlororuthenate(III).
Topics: Bilirubin; Chromatography; Circular Dichroism; Dextrans; Heme; Humans; Indazoles; Models, Chemical; Organometallic Compounds; Protein Binding; Protein Conformation; Serum Albumin; Spectrometry, Fluorescence; Spectrophotometry; Ultraviolet Rays; Warfarin | 2000 |
NO-independent regulatory site on soluble guanylate cyclase.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cyclic N-Oxides; Cysteine; Disease Models, Animal; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Imidazoles; In Vitro Techniques; Indazoles; Molecular Sequence Data; Nitric Oxide; Photoaffinity Labels; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Rats; Solubility | 2001 |
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility | 2001 |
Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase.
Topics: Acrylamide; Circular Dichroism; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Models, Chemical; Models, Molecular; Nitric Oxide; Nitric Oxide Donors; Protein Conformation; Protein Structure, Secondary; Spectrometry, Fluorescence; Tryptophan | 2001 |
A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.
Topics: Animals; Cattle; Cell Line; Cloning, Molecular; Enzyme Activation; Enzyme Activators; Gene Deletion; Guanylate Cyclase; Heme; Humans; Indazoles; Nitric Oxide; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Spodoptera | 2003 |
Preparation of heme-free soluble guanylate cyclase.
Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc | 2003 |
Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP.
Topics: Animals; Cattle; Drug Synergism; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Heme; Imidazoles; In Vitro Techniques; Indazoles; Solubility; Spectrum Analysis, Raman | 2004 |
Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.
Topics: Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Protein Conformation; Pyrazoles; Pyridines; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Structure-Activity Relationship | 2005 |
Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
Topics: Alcohols; Chemistry, Pharmaceutical; Drug Design; Electrons; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Indazoles; Kinetics; Models, Chemical; Nitric Oxide; Organophosphonates; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Temperature | 2007 |
Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.
Topics: Animals; Enzyme Inhibitors; Halogenation; Heme; Indazoles; Male; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2009 |
Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
Topics: Animals; Binding Sites; Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrum Analysis, Raman | 2010 |
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.
Topics: Alanine; Animals; Aspartic Acid; Chlorocebus aethiops; COS Cells; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase | 2011 |
Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies.
Topics: Antineoplastic Agents; Bilirubin; Binding, Competitive; Heme; Humans; Indazoles; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Serum Albumin; Spectrometry, Fluorescence | 2013 |
YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.
Topics: Allosteric Regulation; Animals; Carbon Monoxide; Cattle; Guanylate Cyclase; Heme; Indazoles; Manduca; Models, Molecular; Nitric Oxide; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Surface Plasmon Resonance | 2014 |
Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties.
Topics: Benzylamines; Binding Sites; Drug Discovery; Heme; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Indazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Molecular Docking Simulation; Structure-Activity Relationship | 2016 |
Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity.
Topics: Binding Sites; Enzyme Inhibitors; Heme; Humans; Indazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Molecular Docking Simulation; Protein Conformation | 2019 |