indazoles and gsk343
indazoles has been researched along with gsk343 in 32 studies
Research
Studies (32)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 24 (75.00) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Amatangelo, MD; Conejo-Garcia, JR; Garipov, A; Li, H; Speicher, DW; Zhang, R | 1 |
| Hsiao, HH; Liu, TP; Lo, HL; Wei, LS; Yang, PM | 1 |
| Chen, J; Ding, M; Gao, Y; Li, Z; Shi, L; Wang, C; Xu, D; Zhang, H | 1 |
| Beijnen, JH; Buil, LC; de Gooijer, MC; Li, G; van Tellingen, O; Zhang, P | 1 |
| Archin, NM; Burch, BD; Margolis, DM; McManamy, ME; Tripathy, MK | 1 |
| Kim, KH; Roberts, CW | 1 |
| Cao, W; Dai, L; Liang, W; Liu, Z; Qin, S; Xiong, X; Ye, D; Zhang, J | 1 |
| Andrews, C; Biron, VL; Côté, DW; Harris, J; Idris, S; Kostiuk, M; Lindsay, C; O'Connell, DA; Seikaly, H | 1 |
| Dong, P; Hanley, SJ; Hirata, N; Ihira, K; Konno, Y; Kudo, M; Noguchi, M; Sakuragi, N; Suizu, F; Watari, H; Xiong, Y; Yamada, T | 1 |
| Bertoni, F; Bujisic, B; Chelbi, S; De Gassart, A; Demaria, O; Gilliet, M; Martinon, F; Tallant, R; Zaffalon, L | 1 |
| Carcaboso, AM; Comet, I; de Torres, C; Helin, K; Højfeldt, JW; Jensen, ON; Johansen, JV; Lavarino, C; Leblanc, B; Mohammad, F; Mora, J; Olaciregui, NG; Pandey, DP; Porse, BT; Rapin, N; Suñol, M; Tvardovskiy, A; Weissmann, S; Zheng, C | 1 |
| Anderson, L; daSilva, LF; Gomes, MR; Mourão, MM; Pereira, ADSA; Pierce, R; Romier, C; Verjovski-Almeida, S | 1 |
| Cong, Z; Dan, T; Liyuan, F; Shijun, L; Zhongchao, W | 1 |
| Biron, VL; Harris, J; Kostiuk, MA; Lindsay, CD; O'Connell, DA; Seikaly, H | 1 |
| Dai, J; Hu, Y; Li, X; Wang, Y; Williams, BR; Xu, D; Xu, P; Yan, F; Ying, L; Zhao, Y | 1 |
| Bulic, M; Dupéré-Richer, D; Ezponda, T; Huang, X; Keats, J; Kelleher, N; Licht, JD; Maji, S; Nabet, B; Occhionorelli, M; Oyer, J; Patel, T; Popovic, R; Riva, A; Shah, MY; Small, EC; Tonon, G; Varghese, N; Will, CM; Zheng, Y | 1 |
| Colón-Caraballo, M; Flores, I; Lessey, B; Mendoza, A; Soto-Vargas, JL; Torres-Reverón, A; Urrutia, R; Young, SL | 1 |
| Isselbacher, EM; Jaffer, FA; Jassar, AS; Kessinger, CW; Lindsay, ME; Lino Cardenas, CL; MacDonald, C | 1 |
| Amaral, MS; Angeli, CB; Asif, H; Carneiro, VC; daSilva, LF; Fantappie, MR; Morales-Vicente, DA; Palmisano, G; Pereira, ASA; Pierce, RJ; Pires, DS; Setubal, JC; Vasconcelos, EJR; Verjovski-Almeida, S | 1 |
| Ma, L; Paulson, EE; Ross, PJ; Schultz, RM; Wang, H | 1 |
| Chen, P; Cui, D; He, J; Huang, D; Jiang, L; Li, L; Ma, T; Qi, J; Schmitt, CA; Shao, S; Tao, R; Wang, J; Wu, C; Xiong, J; Yu, D; Yu, Y; Zhou, B | 1 |
| Huang, J; Huang, S; Li, QJ; Long, H; Symonds, ALJ; Tang, X; Wan, YY; Wang, Z; Xu, L; Zhou, J; Zhu, B | 1 |
| Akritidou, MA; Anagnostopoulos, A; Belloni, D; Chartomatsidou, E; Ferrero, E; Ghia, P; Kotta, K; Ntoufa, S; Papakonstantinou, N; Rosenquist, R; Rovida, A; Stamatopoulos, K; Stavroyianni, N; Trangas, T | 1 |
| Dai, L; Li, A; Li, X; Liu, W; Liu, Z; Qin, S; Wang, P; Xiong, X; Zhang, J; Zhang, Z | 1 |
| Alexandre, PA; Cordeiro, YG; Fukumasu, H; Müller, S; Pires, PRL; Saranholi, BH; Silva, ER; Xavier, PLP | 1 |
| Liu, D; Wang, Q; Wang, R; Xu, L; Zhang, X | 1 |
| Appleyard, CB; Flores, I; Luna, N; Seguinot-Tarafa, I; Suarez, E | 1 |
| Chen, C; Chen, J; Gong, H; Li, W; Li, Y; Liu, C; Liu, H; Liu, M; Shi, R; Yuan, Y; Zhang, H; Zhang, Z | 1 |
| Damle, M; Kim, J; Kingston, RE; Miller, SA | 1 |
| Bugide, S; Green, MR; Gupta, R; Wajapeyee, N | 1 |
| Li, Y; Wang, X; Yan, H; Yin, J; Yu, M | 1 |
| Abraham, MJ; Del Rincón, SV; Dupéré-Richer, D; Emond, A; Johnson, NA; Kinal, M; Licht, JD; Mann, KK; Miller, WH; Pettersson, F; Preston, SEJ; Riva, A; Rys, RN | 1 |
Reviews
1 review(s) available for indazoles and gsk343
| Article | Year |
|---|---|
Targeting EZH2 in cancer.
Topics: Benzamides; Biphenyl Compounds; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Indoles; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasms; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Pyridones | 2016 |
Other Studies
31 other study(ies) available for indazoles and gsk343
| Article | Year |
|---|---|
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.
Topics: Antineoplastic Agents; Carcinoma, Ovarian Epithelial; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Female; Humans; Indazoles; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polycomb Repressive Complex 2; Pyridones; Tumor Microenvironment | 2013 |
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Knockdown Techniques; Hep G2 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Indazoles; Niacinamide; Phenylurea Compounds; Polycomb Repressive Complex 2; Pyridones; S-Adenosylmethionine; Sorafenib | 2015 |
The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer.
Topics: Animals; Cadherins; Carcinogenesis; Cell Movement; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Indazoles; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Polycomb Repressive Complex 2; Pyridones; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2015 |
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Benzamides; Biological Availability; Biphenyl Compounds; Blood-Brain Barrier; Cell Line; Dogs; Drug Evaluation, Preclinical; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Indazoles; Indoles; Madin Darby Canine Kidney Cells; Mice; Mice, Knockout; Morpholines; Polycomb Repressive Complex 2; Pyridones | 2015 |
H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells.
Topics: Analysis of Variance; CD4-Positive T-Lymphocytes; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Enzyme-Linked Immunosorbent Assay; Histones; HIV; Humans; Hydroxamic Acids; Immunoblotting; Indazoles; Methylation; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Proviruses; Pyridones; RNA, Small Interfering; Vorinostat | 2015 |
Fuse-binding protein 1 is a target of the EZH2 inhibitor GSK343, in osteosarcoma cells.
Topics: Apoptosis; Autophagy; Bone Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; DNA Helicases; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Indazoles; Osteosarcoma; Proto-Oncogene Proteins c-myc; Pyridones; RNA-Binding Proteins | 2016 |
Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Humans; Immunohistochemistry; Indazoles; Oropharyngeal Neoplasms; Papillomavirus Infections; Polymerase Chain Reaction; Pyridones; Tumor Cells, Cultured | 2016 |
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis.
Topics: Animals; Cell Line, Tumor; Disease Progression; Endometrial Neoplasms; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Humans; Indazoles; Mice; Mice, Inbred BALB C; MicroRNAs; Nuclear Proteins; Pyridones; Transfection; Twist-Related Protein 1; Xenograft Model Antitumor Assays | 2017 |
Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Endoribonucleases; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Germinal Center; Histones; Humans; Indazoles; Leupeptins; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, 129 Strain; Plasma Cells; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyridones; RNA, Messenger; Signal Transduction; X-Box Binding Protein 1; Xenograft Model Antitumor Assays | 2017 |
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
Topics: Animals; Benzamides; Biphenyl Compounds; Brain Neoplasms; Brain Stem Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Chromatography, Liquid; CRISPR-Cas Systems; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Gene Knockout Techniques; Glioblastoma; Glioma; Histones; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Indazoles; Mice; Mice, SCID; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasm Transplantation; Neural Stem Cells; Polycomb Repressive Complex 2; Pyridones; Tandem Mass Spectrometry; Tumor Suppressor Protein p14ARF | 2017 |
Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.
Topics: Acetylation; Animals; Chromatin; DNA Replication; Down-Regulation; Female; Genome, Helminth; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Indazoles; Male; Molecular Docking Simulation; Promoter Regions, Genetic; Pyridones; Schistosoma mansoni; Transcriptome; Up-Regulation | 2017 |
[Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation].
Topics: Arginase; Cell Differentiation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Indazoles; Interleukin-10; Lipopolysaccharides; Macrophages; Nitric Oxide Synthase Type II; Periodontitis; Phagocytosis; Pyridones; Tumor Necrosis Factor-alpha | 2017 |
Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclin D1; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; ErbB Receptors; Gene Expression Regulation, Neoplastic; Histones; Humans; Indazoles; Methylation; Oropharyngeal Neoplasms; Papillomavirus Infections; Pyridones | 2017 |
(-)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Catechin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Neoplasm Invasiveness; Pyridones | 2018 |
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
Topics: Animals; Carcinogenesis; Cell Adhesion; Cell Dedifferentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Indazoles; Interferon Regulatory Factors; Lysine; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Mutation; Nuclear Proteins; Phenotype; Pyridones; Transcription, Genetic | 2017 |
Effects of histone methyltransferase inhibition in endometriosis.
Topics: Adult; Cell Line; Cell Movement; Cell Proliferation; Endometriosis; Endometrium; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Humans; Indazoles; Middle Aged; Pyridones | 2018 |
Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm.
Topics: Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Disease Models, Animal; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibrillin-1; Gene Knockout Techniques; Histones; Humans; Indazoles; Losartan; Marfan Syndrome; Mice; Mice, Knockout; Microfilament Proteins; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pyridones; RNA, Small Interfering | 2018 |
Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.
Topics: Animals; DNA Replication; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Gene Expression Regulation; Indazoles; Locomotion; Male; Metabolic Networks and Pathways; Microscopy, Electron, Scanning; Oviposition; Pyridones; RNA, Untranslated; Schistosoma mansoni; Survival Analysis | 2018 |
Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity.
Topics: Animals; Blastocyst; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Developmental; Histones; Indazoles; Male; Mice; Paternal Inheritance; Pyridones; Transcriptome | 2019 |
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cancer Survivors; Cell Line, Tumor; Cellular Senescence; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Delivery Systems; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Nude; Mixed Function Oxygenases; Proto-Oncogene Proteins; Pyridones; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
Topics: Animals; Cell Differentiation; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Histone Code; Histones; In Vitro Techniques; Indazoles; Indoles; Inflammatory Bowel Diseases; Methylation; Mice; Myeloid-Derived Suppressor Cells; Pyridones | 2019 |
Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia.
Topics: Adenine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; B-Lymphocytes; Bridged Bicyclo Compounds, Heterocyclic; Down-Regulation; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histones; Humans; Indazoles; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Piperidines; Purines; Pyrazoles; Pyridones; Pyrimidines; Quinazolinones; Signal Transduction; Sulfonamides; Tumor Microenvironment | 2019 |
GSK343 induces programmed cell death through the inhibition of EZH2 and FBP1 in osteosarcoma cells.
Topics: Apoptosis; Biomarkers, Tumor; Bone Neoplasms; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Fructose-Bisphosphatase; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Osteosarcoma; Pyridones; Tumor Cells, Cultured | 2020 |
An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells.
Topics: Animals; Antineoplastic Agents; Azepines; Biomarkers, Tumor; Carcinogenesis; Cell Proliferation; Dog Diseases; Dogs; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Testing; Indazoles; Mammary Neoplasms, Animal; Multigene Family; Neoplastic Stem Cells; Pyridones; Transcription Factors; Triazoles | 2019 |
GSK343, an inhibitor of EZH2, mitigates fibrosis and inflammation mediated by HIF-1α in human peritoneal mesothelial cells treated with high glucose.
Topics: Anti-Inflammatory Agents; Cell Line; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Fibrosis; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Inflammation; MicroRNAs; Peritoneum; Pyridones | 2020 |
Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis.
Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Indazoles; Pyridones; Rats; Rats, Sprague-Dawley | 2020 |
EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells.
Topics: Adenosine; Adult; Aged; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-1; Humans; Indazoles; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Protein Kinase Inhibitors; Pyridones; RNA Interference; RNA, Neoplasm; RNA, Small Interfering; Signal Transduction | 2020 |
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
Topics: Animals; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Histones; Indazoles; Lysine; Methylation; Mice; Phenotype; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Pyridones; Transcriptome | 2021 |
EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
Topics: Animals; Benzopyrans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Decitabine; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Indazoles; Indoles; Killer Cells, Natural; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phenols; Pyridones; Sulfones; Triazoles | 2021 |
Enhanced Calcium Signal Induces NK Cell Degranulation but Inhibits Its Cytotoxic Activity.
Topics: Benzamides; Calcium; Calcium Signaling; Cell Degranulation; Cell Line; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Indazoles; Killer Cells, Natural; Lymphocyte Activation; Methylation; Piperazines; Pyridones; TRPP Cation Channels | 2022 |
Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Lymphoma, Large B-Cell, Diffuse; Phenotype; Pyridones | 2022 |