Compounds > indazoles
Page last updated: 2024-08-21

indazoles and gsk343

indazoles has been researched along with gsk343 in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's24 (75.00)24.3611
2020's8 (25.00)2.80

Authors

AuthorsStudies
Amatangelo, MD; Conejo-Garcia, JR; Garipov, A; Li, H; Speicher, DW; Zhang, R1
Hsiao, HH; Liu, TP; Lo, HL; Wei, LS; Yang, PM1
Chen, J; Ding, M; Gao, Y; Li, Z; Shi, L; Wang, C; Xu, D; Zhang, H1
Beijnen, JH; Buil, LC; de Gooijer, MC; Li, G; van Tellingen, O; Zhang, P1
Archin, NM; Burch, BD; Margolis, DM; McManamy, ME; Tripathy, MK1
Kim, KH; Roberts, CW1
Cao, W; Dai, L; Liang, W; Liu, Z; Qin, S; Xiong, X; Ye, D; Zhang, J1
Andrews, C; Biron, VL; Côté, DW; Harris, J; Idris, S; Kostiuk, M; Lindsay, C; O'Connell, DA; Seikaly, H1
Dong, P; Hanley, SJ; Hirata, N; Ihira, K; Konno, Y; Kudo, M; Noguchi, M; Sakuragi, N; Suizu, F; Watari, H; Xiong, Y; Yamada, T1
Bertoni, F; Bujisic, B; Chelbi, S; De Gassart, A; Demaria, O; Gilliet, M; Martinon, F; Tallant, R; Zaffalon, L1
Carcaboso, AM; Comet, I; de Torres, C; Helin, K; Højfeldt, JW; Jensen, ON; Johansen, JV; Lavarino, C; Leblanc, B; Mohammad, F; Mora, J; Olaciregui, NG; Pandey, DP; Porse, BT; Rapin, N; Suñol, M; Tvardovskiy, A; Weissmann, S; Zheng, C1
Anderson, L; daSilva, LF; Gomes, MR; Mourão, MM; Pereira, ADSA; Pierce, R; Romier, C; Verjovski-Almeida, S1
Cong, Z; Dan, T; Liyuan, F; Shijun, L; Zhongchao, W1
Biron, VL; Harris, J; Kostiuk, MA; Lindsay, CD; O'Connell, DA; Seikaly, H1
Dai, J; Hu, Y; Li, X; Wang, Y; Williams, BR; Xu, D; Xu, P; Yan, F; Ying, L; Zhao, Y1
Bulic, M; Dupéré-Richer, D; Ezponda, T; Huang, X; Keats, J; Kelleher, N; Licht, JD; Maji, S; Nabet, B; Occhionorelli, M; Oyer, J; Patel, T; Popovic, R; Riva, A; Shah, MY; Small, EC; Tonon, G; Varghese, N; Will, CM; Zheng, Y1
Colón-Caraballo, M; Flores, I; Lessey, B; Mendoza, A; Soto-Vargas, JL; Torres-Reverón, A; Urrutia, R; Young, SL1
Isselbacher, EM; Jaffer, FA; Jassar, AS; Kessinger, CW; Lindsay, ME; Lino Cardenas, CL; MacDonald, C1
Amaral, MS; Angeli, CB; Asif, H; Carneiro, VC; daSilva, LF; Fantappie, MR; Morales-Vicente, DA; Palmisano, G; Pereira, ASA; Pierce, RJ; Pires, DS; Setubal, JC; Vasconcelos, EJR; Verjovski-Almeida, S1
Ma, L; Paulson, EE; Ross, PJ; Schultz, RM; Wang, H1
Chen, P; Cui, D; He, J; Huang, D; Jiang, L; Li, L; Ma, T; Qi, J; Schmitt, CA; Shao, S; Tao, R; Wang, J; Wu, C; Xiong, J; Yu, D; Yu, Y; Zhou, B1
Huang, J; Huang, S; Li, QJ; Long, H; Symonds, ALJ; Tang, X; Wan, YY; Wang, Z; Xu, L; Zhou, J; Zhu, B1
Akritidou, MA; Anagnostopoulos, A; Belloni, D; Chartomatsidou, E; Ferrero, E; Ghia, P; Kotta, K; Ntoufa, S; Papakonstantinou, N; Rosenquist, R; Rovida, A; Stamatopoulos, K; Stavroyianni, N; Trangas, T1
Dai, L; Li, A; Li, X; Liu, W; Liu, Z; Qin, S; Wang, P; Xiong, X; Zhang, J; Zhang, Z1
Alexandre, PA; Cordeiro, YG; Fukumasu, H; Müller, S; Pires, PRL; Saranholi, BH; Silva, ER; Xavier, PLP1
Liu, D; Wang, Q; Wang, R; Xu, L; Zhang, X1
Appleyard, CB; Flores, I; Luna, N; Seguinot-Tarafa, I; Suarez, E1
Chen, C; Chen, J; Gong, H; Li, W; Li, Y; Liu, C; Liu, H; Liu, M; Shi, R; Yuan, Y; Zhang, H; Zhang, Z1
Damle, M; Kim, J; Kingston, RE; Miller, SA1
Bugide, S; Green, MR; Gupta, R; Wajapeyee, N1
Li, Y; Wang, X; Yan, H; Yin, J; Yu, M1
Abraham, MJ; Del Rincón, SV; Dupéré-Richer, D; Emond, A; Johnson, NA; Kinal, M; Licht, JD; Mann, KK; Miller, WH; Pettersson, F; Preston, SEJ; Riva, A; Rys, RN1

Reviews

1 review(s) available for indazoles and gsk343

ArticleYear
Targeting EZH2 in cancer.
    Nature medicine, 2016, Volume: 22, Issue:2

    Topics: Benzamides; Biphenyl Compounds; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Indoles; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasms; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Pyridones

2016

Other Studies

31 other study(ies) available for indazoles and gsk343

ArticleYear
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.
    Cell cycle (Georgetown, Tex.), 2013, Jul-01, Volume: 12, Issue:13

    Topics: Antineoplastic Agents; Carcinoma, Ovarian Epithelial; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Female; Humans; Indazoles; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polycomb Repressive Complex 2; Pyridones; Tumor Microenvironment

2013
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.
    Anti-cancer drugs, 2015, Volume: 26, Issue:2

    Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Knockdown Techniques; Hep G2 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Indazoles; Niacinamide; Phenylurea Compounds; Polycomb Repressive Complex 2; Pyridones; S-Adenosylmethionine; Sorafenib

2015
The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer.
    Clinical and experimental pharmacology & physiology, 2015, Volume: 42, Issue:5

    Topics: Animals; Cadherins; Carcinogenesis; Cell Movement; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Indazoles; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Polycomb Repressive Complex 2; Pyridones; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2015
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
    International journal of cancer, 2015, Oct-15, Volume: 137, Issue:8

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Benzamides; Biological Availability; Biphenyl Compounds; Blood-Brain Barrier; Cell Line; Dogs; Drug Evaluation, Preclinical; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Indazoles; Indoles; Madin Darby Canine Kidney Cells; Mice; Mice, Knockout; Morpholines; Polycomb Repressive Complex 2; Pyridones

2015
H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells.
    Journal of virology, 2015, Volume: 89, Issue:16

    Topics: Analysis of Variance; CD4-Positive T-Lymphocytes; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Enzyme-Linked Immunosorbent Assay; Histones; HIV; Humans; Hydroxamic Acids; Immunoblotting; Indazoles; Methylation; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Proviruses; Pyridones; RNA, Small Interfering; Vorinostat

2015
Fuse-binding protein 1 is a target of the EZH2 inhibitor GSK343, in osteosarcoma cells.
    International journal of oncology, 2016, Volume: 49, Issue:2

    Topics: Apoptosis; Autophagy; Bone Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; DNA Helicases; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Indazoles; Osteosarcoma; Proto-Oncogene Proteins c-myc; Pyridones; RNA-Binding Proteins

2016
Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2016, Oct-28, Volume: 45, Issue:1

    Topics: Adenosine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Humans; Immunohistochemistry; Indazoles; Oropharyngeal Neoplasms; Papillomavirus Infections; Polymerase Chain Reaction; Pyridones; Tumor Cells, Cultured

2016
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis.
    Oncotarget, 2017, Feb-21, Volume: 8, Issue:8

    Topics: Animals; Cell Line, Tumor; Disease Progression; Endometrial Neoplasms; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Humans; Indazoles; Mice; Mice, Inbred BALB C; MicroRNAs; Nuclear Proteins; Pyridones; Transfection; Twist-Related Protein 1; Xenograft Model Antitumor Assays

2017
Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.
    Blood, 2017, 04-27, Volume: 129, Issue:17

    Topics: Animals; B-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Endoribonucleases; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Germinal Center; Histones; Humans; Indazoles; Leupeptins; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, 129 Strain; Plasma Cells; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyridones; RNA, Messenger; Signal Transduction; X-Box Binding Protein 1; Xenograft Model Antitumor Assays

2017
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
    Nature medicine, 2017, Volume: 23, Issue:4

    Topics: Animals; Benzamides; Biphenyl Compounds; Brain Neoplasms; Brain Stem Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Chromatography, Liquid; CRISPR-Cas Systems; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Gene Knockout Techniques; Glioblastoma; Glioma; Histones; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Indazoles; Mice; Mice, SCID; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasm Transplantation; Neural Stem Cells; Polycomb Repressive Complex 2; Pyridones; Tandem Mass Spectrometry; Tumor Suppressor Protein p14ARF

2017
Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.
    PLoS neglected tropical diseases, 2017, Volume: 11, Issue:4

    Topics: Acetylation; Animals; Chromatin; DNA Replication; Down-Regulation; Female; Genome, Helminth; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Indazoles; Male; Molecular Docking Simulation; Promoter Regions, Genetic; Pyridones; Schistosoma mansoni; Transcriptome; Up-Regulation

2017
[Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2017, Jun-01, Volume: 35, Issue:3

    Topics: Arginase; Cell Differentiation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Indazoles; Interleukin-10; Lipopolysaccharides; Macrophages; Nitric Oxide Synthase Type II; Periodontitis; Phagocytosis; Pyridones; Tumor Necrosis Factor-alpha

2017
Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas.
    Clinical epigenetics, 2017, Volume: 9

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclin D1; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; ErbB Receptors; Gene Expression Regulation, Neoplastic; Histones; Humans; Indazoles; Methylation; Oropharyngeal Neoplasms; Papillomavirus Infections; Pyridones

2017
(-)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells.
    Clinical and experimental pharmacology & physiology, 2018, Volume: 45, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Catechin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Neoplasm Invasiveness; Pyridones

2018
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
    Cell reports, 2017, Oct-17, Volume: 21, Issue:3

    Topics: Animals; Carcinogenesis; Cell Adhesion; Cell Dedifferentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Indazoles; Interferon Regulatory Factors; Lysine; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Mutation; Nuclear Proteins; Phenotype; Pyridones; Transcription, Genetic

2017
Effects of histone methyltransferase inhibition in endometriosis.
    Biology of reproduction, 2018, 08-01, Volume: 99, Issue:2

    Topics: Adult; Cell Line; Cell Movement; Cell Proliferation; Endometriosis; Endometrium; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Humans; Indazoles; Middle Aged; Pyridones

2018
Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm.
    JCI insight, 2018, 03-08, Volume: 3, Issue:5

    Topics: Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Disease Models, Animal; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibrillin-1; Gene Knockout Techniques; Histones; Humans; Indazoles; Losartan; Marfan Syndrome; Mice; Mice, Knockout; Microfilament Proteins; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pyridones; RNA, Small Interfering

2018
Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:10

    Topics: Animals; DNA Replication; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Gene Expression Regulation; Indazoles; Locomotion; Male; Metabolic Networks and Pathways; Microscopy, Electron, Scanning; Oviposition; Pyridones; RNA, Untranslated; Schistosoma mansoni; Survival Analysis

2018
Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity.
    Epigenetics, 2019, Volume: 14, Issue:1

    Topics: Animals; Blastocyst; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Developmental; Histones; Indazoles; Male; Mice; Paternal Inheritance; Pyridones; Transcriptome

2019
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer.
    Theranostics, 2019, Volume: 9, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cancer Survivors; Cell Line, Tumor; Cellular Senescence; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Delivery Systems; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Nude; Mixed Function Oxygenases; Proto-Oncogene Proteins; Pyridones; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2019
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
    Nature communications, 2019, 06-03, Volume: 10, Issue:1

    Topics: Animals; Cell Differentiation; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Histone Code; Histones; In Vitro Techniques; Indazoles; Indoles; Inflammatory Bowel Diseases; Methylation; Mice; Myeloid-Derived Suppressor Cells; Pyridones

2019
Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia.
    Blood advances, 2019, 06-25, Volume: 3, Issue:12

    Topics: Adenine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; B-Lymphocytes; Bridged Bicyclo Compounds, Heterocyclic; Down-Regulation; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histones; Humans; Indazoles; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Piperidines; Purines; Pyrazoles; Pyridones; Pyrimidines; Quinazolinones; Signal Transduction; Sulfonamides; Tumor Microenvironment

2019
GSK343 induces programmed cell death through the inhibition of EZH2 and FBP1 in osteosarcoma cells.
    Cancer biology & therapy, 2020, Volume: 21, Issue:3

    Topics: Apoptosis; Biomarkers, Tumor; Bone Neoplasms; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Fructose-Bisphosphatase; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Osteosarcoma; Pyridones; Tumor Cells, Cultured

2020
An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells.
    Scientific reports, 2019, 11-22, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents; Azepines; Biomarkers, Tumor; Carcinogenesis; Cell Proliferation; Dog Diseases; Dogs; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Testing; Indazoles; Mammary Neoplasms, Animal; Multigene Family; Neoplastic Stem Cells; Pyridones; Transcription Factors; Triazoles

2019
GSK343, an inhibitor of EZH2, mitigates fibrosis and inflammation mediated by HIF-1α in human peritoneal mesothelial cells treated with high glucose.
    European journal of pharmacology, 2020, Aug-05, Volume: 880

    Topics: Anti-Inflammatory Agents; Cell Line; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Fibrosis; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Inflammation; MicroRNAs; Peritoneum; Pyridones

2020
Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis.
    Reproductive sciences (Thousand Oaks, Calif.), 2020, Volume: 27, Issue:9

    Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Indazoles; Pyridones; Rats; Rats, Sprague-Dawley

2020
EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells.
    BMC cancer, 2020, Dec-04, Volume: 20, Issue:1

    Topics: Adenosine; Adult; Aged; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-1; Humans; Indazoles; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Protein Kinase Inhibitors; Pyridones; RNA Interference; RNA, Neoplasm; RNA, Small Interfering; Signal Transduction

2020
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
    Development (Cambridge, England), 2021, 04-01, Volume: 148, Issue:7

    Topics: Animals; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Histones; Indazoles; Lysine; Methylation; Mice; Phenotype; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Pyridones; Transcriptome

2021
EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 07-27, Volume: 118, Issue:30

    Topics: Animals; Benzopyrans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Decitabine; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Indazoles; Indoles; Killer Cells, Natural; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phenols; Pyridones; Sulfones; Triazoles

2021
Enhanced Calcium Signal Induces NK Cell Degranulation but Inhibits Its Cytotoxic Activity.
    Journal of immunology (Baltimore, Md. : 1950), 2022, 01-15, Volume: 208, Issue:2

    Topics: Benzamides; Calcium; Calcium Signaling; Cell Degranulation; Cell Line; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Indazoles; Killer Cells, Natural; Lymphocyte Activation; Methylation; Piperazines; Pyridones; TRPP Cation Channels

2022
Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype.
    Molecular cancer therapeutics, 2022, 04-01, Volume: 21, Issue:4

    Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Lymphoma, Large B-Cell, Diffuse; Phenotype; Pyridones

2022