imipramine has been researched along with prazosin in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (23.29) | 18.7374 |
| 1990's | 18 (24.66) | 18.2507 |
| 2000's | 20 (27.40) | 29.6817 |
| 2010's | 17 (23.29) | 24.3611 |
| 2020's | 1 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Colau, D; Dolusić, E; Frédérick, R; Larrieu, P; Masereel, B; Moineaux, L; Pilotte, L; Pochet, L; Stroobant, V; Van den Eynde, B; Wouters, J | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Collu, M; D'Aquila, PS; Gessa, GL; Serra, G | 1 |
| Hayakawa, H; Shimizu, M; Yamawaki, S | 1 |
| Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 2 |
| Barrett, JE; Zhang, L | 1 |
| Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV | 1 |
| Cai, B; Matsumoto, K; Ohta, H; Satoh, T; Watanabe, H | 1 |
| Maj, J; Rogóz, Z; Skuza, G | 1 |
| Ferrari, RA; Hamel, LT; Haubrich, DR; Perrone, MH | 1 |
| Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC | 1 |
| Barkai, AI; Butler, PD; Edwards, E | 1 |
| Chiu, A; Li, PP; Sibony, D; Warsh, JJ | 1 |
| Müller, WE; Rick-Brand, S | 1 |
| Wein, AJ | 1 |
| Hong, KW; Lee, WS; Rhim, BY | 1 |
| Caplan, NB; Cubeddu, LX; Ferry, DG | 1 |
| Harris, JC; Newman, JD | 1 |
| Reny-Palasse, V; Rips, R | 1 |
| Arbilla, S; Bartholini, G; Claustre, Y; Dedek, J; Dennis, T; Langer, SZ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Wood, M | 1 |
| Danti, S; Martin, P; Poncelet, M; Simon, P; Soubrié, P | 1 |
| Pilc, A; Vetulani, J | 1 |
| Antkiewicz-Michaluk, L; Rokosz-Pelc, A; Vetulani, J | 1 |
| Insel, PA; Motulsky, HJ | 1 |
| Górka, Z; Maj, J; Melzacka, M; Pilc, A; Rawłów, A | 1 |
| Amabeoku, G; Chandomba, R | 1 |
| Hayakawa, H; Nishida, A; Shimizu, M; Yamawaki, S | 1 |
| Amabeoku, GJ | 1 |
| Frew, R; Lundy, PM | 1 |
| Breese, GR; Duncan, GE; Johnson, KB; Knapp, DJ | 1 |
| Endoh, M; Morinobu, S; Okuyama, N; Totsuka, S | 1 |
| Al-Damluji, S; Kopin, IJ | 1 |
| Duman, RS; Morinobu, S; Strausbaugh, H; Terwilliger, R | 1 |
| Chang, HC; Cheng, JT; Hsieh, CH; Hsieh, JT; Law, HS | 1 |
| Sahebgharani, M; Zarrindast, MR | 1 |
| Ghiasvand, M; Homayoun, H; Khavandgar, S; Rostami, P; Shafaghi, B; Zarrindast, MR | 1 |
| Sahebgharani, M; Vousooghi, N; Zarrindast, MR | 1 |
| Torkaman-Boutorabi, A; Zarrindast, MR | 1 |
| Antunes, E; De Nucci, G; Okuyama, CE; Priviero, FB; Teixeira, CE | 1 |
| Dhingra, D; Sharma, A | 1 |
| Hirano, S; Kamei, J; Miyata, S; Onodera, K | 1 |
| Costentin, J; Do Rego, JC; Müller, LG; Nunes, JM; Rates, SM; Stein, AC; Stolz, ED; Viana, AF; von Poser, GL | 1 |
3 review(s) available for imipramine and prazosin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Pharmacologic treatment of lower urinary tract dysfunction in the female patient.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Bethanechol; Bethanechol Compounds; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Muscle Relaxants, Central; Muscle, Smooth; Parasympatholytics; Phenoxybenzamine; Prazosin; Receptors, Adrenergic; Urethra; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder Neck Obstruction; Urination Disorders; Urologic Diseases | 1985 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Cardiac Surgical Procedures; Chlorpromazine; Dipyridamole; Disopyramide; Etidocaine; Female; Fentanyl; Half-Life; Humans; Imipramine; Kidney Diseases; Lidocaine; Liver; Mathematics; Meperidine; Methadone; Myocardial Infarction; Orosomucoid; Prazosin; Pregnancy; Propranolol; Protein Binding; Quinidine; Serum Albumin; Sex Factors | 1986 |
70 other study(ies) available for imipramine and prazosin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Line; Drug Design; Enzyme Inhibitors; Humans; Immunologic Factors; Indoles; Kinetics; Mice; Neoplasms; Structure-Activity Relationship; Tryptophan Oxygenase | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Role of alpha 1 receptors in the behavioural supersensitivity to D2 agonists induced by chronic treatment with imipramine.
Topics: Adrenergic alpha-Antagonists; Animals; Dopamine Agents; Ergolines; Imipramine; Male; Motor Activity; Prazosin; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2 | 1992 |
The effects of electroconvulsive shock or imipramine on subtypes of alpha 1-adrenoceptors in the frontal cortex of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Clonidine; Dioxanes; Electroshock; Hippocampus; Imipramine; In Vitro Techniques; Kinetics; Male; Prazosin; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1992 |
The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist.
Topics: Animals; Antidepressive Agents; Benzazepines; Citalopram; Dizocilpine Maleate; Fluoxetine; Imipramine; Isomerism; Male; Maprotiline; Motor Activity; Prazosin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Sulpiride | 1992 |
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Dizocilpine Maleate; Haloperidol; Imipramine; Male; Mianserin; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Swimming | 1992 |
Involvement of 5-HT1A activity in the discriminative stimulus effects of imipramine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Columbidae; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Imipramine; Male; Piperazines; Prazosin; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1991 |
Effects of thyroid status on the characteristics of alpha 1-, alpha 2-, beta, imipramine and GABA receptors in the rat brain.
Topics: Animals; Brain; Dihydroalprenolol; Hyperthyroidism; Hypothyroidism; Imipramine; Kinetics; Male; Muscimol; Organ Specificity; Prazosin; Propylthiouracil; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, GABA-A; Reference Values; Thyroid Gland; Triiodothyronine; Yohimbine | 1991 |
Desipramine enhances isolation-induced aggressive behavior in mice.
Topics: Aggression; Animals; Clonidine; Desipramine; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Activity; Phentolamine; Prazosin; Social Isolation; Yohimbine | 1991 |
Antidepressant drugs increase the locomotor hyperactivity induced by MK-801 in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Dizocilpine Maleate; Drug Interactions; Haloperidol; Imipramine; Male; Mianserin; Motor Activity; Prazosin; Rats; Rats, Inbred Strains | 1991 |
Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro.
Topics: Adrenergic alpha-Antagonists; Amino Acids; Animals; Brain; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Prazosin; Rats; Receptors, Adrenergic, alpha; Synaptosomes; Vas Deferens | 1990 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors | 1988 |
Imipramine and tetrabenazine: effects on monoamine receptor binding sites and phosphoinositide hydrolysis.
Topics: Animals; Dihydroalprenolol; Hydrolysis; Imipramine; Inositol Phosphates; Ketanserin; Kinetics; Male; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Tetrabenazine | 1989 |
Assessment of rat brain alpha 1-adrenoceptor binding and activation of inositol phospholipid turnover following chronic imipramine treatment.
Topics: Animals; Cerebral Cortex; Desipramine; Imipramine; In Vitro Techniques; Inositol Phosphates; Iodocyanopindolol; Norepinephrine; Pindolol; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Sugar Phosphates | 1988 |
Direct and indirect effects of alprazolam and imipramine on alpha 1- and alpha 2-adrenoceptors in mouse forebrain.
Topics: Alprazolam; Animals; Binding, Competitive; Brain Chemistry; Clonidine; Imipramine; Male; Mice; Prazosin; Receptors, Adrenergic, alpha | 1988 |
Enhancement of central and peripheral alpha 1-adrenoceptor sensitivity and reduction of alpha 2-adrenoceptor sensitivity following chronic imipramine treatment in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Female; Imipramine; In Vitro Techniques; Kinetics; Male; Muscle, Smooth, Vascular; Muscles; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein.
Topics: Adrenergic alpha-Antagonists; Antidepressive Agents; Antidepressive Agents, Tricyclic; Binding, Competitive; Chromatography, Liquid; Dialysis; Drug Interactions; Humans; Imipramine; Orosomucoid; Prazosin; Protein Binding | 1986 |
Mediation of separation distress by alpha 2-adrenergic mechanisms in a non-human primate.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety, Separation; Clonidine; Imipramine; Male; Prazosin; Receptors, Adrenergic, alpha; Saimiri; Vocalization, Animal; Yohimbine | 1987 |
Potentiation by TRH of the effect of imipramine on the forced-swimming test.
Topics: Animals; Drug Synergism; Drug Tolerance; Imipramine; Male; Mice; Morphine; Naloxone; Phenoxybenzamine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Opioid; Swimming; Thyrotropin-Releasing Hormone; Yohimbine | 1985 |
Fengabine, a novel antidepressant GABAergic agent. II. Effect on cerebral noradrenergic, serotonergic and GABAergic transmission in the rat.
Topics: Animals; Antidepressive Agents; Brain; Chlorophenols; Clonidine; Dihydroalprenolol; gamma-Aminobutyric Acid; Imipramine; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Spiperone; Synaptic Transmission | 1987 |
Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profile of GABA agonists and imipramine-like drugs in animals.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Imipramine; Male; Muscimol; Norepinephrine; Penbutolol; Picrotoxin; Prazosin; Rats; Rats, Inbred Strains | 1987 |
Postdecapitation convulsions in the rat measured with an Animex motility meter: relation to central alpha-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Brain; Imipramine; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Seizures; Spinal Cord | 1982 |
Chronic administration of antidepressant drugs increases the density of cortical [3H]prazosin binding sites in the rat.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Binding Sites; Cerebral Cortex; Chlorprothixene; Citalopram; Imipramine; Male; Methotrimeprazine; Prazosin; Propylamines; Quinazolines; Rats; Rats, Inbred Strains; Spiperone | 1984 |
[3H]Dihydroergocryptine binding to alpha-adrenergic receptors of human platelets. A reassessment using the selective radioligands [3H]prazosin, [3H]yohimbine, and [3H]rauwolscine.
Topics: Binding, Competitive; Blood Platelets; Dihydroergotoxine; Humans; Imipramine; In Vitro Techniques; Phenoxybenzamine; Prazosin; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Yohimbine | 1982 |
Chronic treatment with imipramine: further functional evidence for the enhanced noradrenergic transmission in flexor reflex activity.
Topics: Animals; Desipramine; Hindlimb; Imipramine; Male; Norepinephrine; Phenoxybenzamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex; Spinal Cord; Synaptic Transmission | 1983 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipramine; Male; Mice; Pargyline; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic; Reserpine; Seizures; Strychnine | 1994 |
[Effects of repeated treatment with electroconvulsive shock or imipramine on [3H]prazosin binding sites in the rat frontal cortex].
Topics: Animals; Binding Sites; Cerebral Cortex; Electroshock; Imipramine; Male; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1994 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Droxidopa; Drug Synergism; Idazoxan; Imipramine; Male; Methyltyrosines; Mice; Norepinephrine; Pargyline; Phentolamine; Physostigmine; Prazosin; Reserpine; Seizures; Serotonin | 1993 |
Evidence of mammalian Ca2+ channel inhibitors in venom of the spider Plectreurys tristis.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Imipramine; In Vitro Techniques; Male; Muscle, Smooth; Prazosin; Rats; Rats, Sprague-Dawley; Spider Venoms; Synaptic Transmission; Synaptosomes; Vas Deferens | 1993 |
Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.
Topics: Animals; Antidepressive Agents; Brain; Deoxyglucose; Imipramine; Male; Prazosin; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stress, Physiological; Swimming | 1996 |
Enhancement of 5-hydroxytryptamine-stimulated phosphoinositide hydrolysis in the rat cerebral cortex by repeated immobilization stress.
Topics: Animals; Body Weight; Cerebral Cortex; Hydrolysis; Imipramine; Immobilization; Ketanserin; Male; Phosphatidylinositols; Prazosin; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Stress, Physiological | 1995 |
Binding and competitive inhibition of amine uptake at postsynaptic neurones (transport-P) by tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Cell Line; Gonadotropin-Releasing Hormone; Imipramine; Neurons; Prazosin | 1996 |
Regulation of c-Fos and NGF1-A by antidepressant treatments.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Blotting, Western; Dizocilpine Maleate; DNA-Binding Proteins; Dopamine Antagonists; Early Growth Response Protein 1; Electroshock; Excitatory Amino Acid Antagonists; Frontal Lobe; Genes, fos; Genes, Immediate-Early; Haloperidol; Imipramine; Immediate-Early Proteins; Ketanserin; Male; Prazosin; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Transcription Factors; Transcription, Genetic; Tranylcypromine | 1997 |
In vivo evaluation of serotonergic agents and alpha-adrenergic blockers on premature ejaculation by inhibiting the seminal vesicle pressure response to electrical nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clomipramine; Dose-Response Relationship, Drug; Ejaculation; Electric Stimulation; Fluoxetine; Imipramine; Male; Prazosin; Pressure; Rats; Rats, Wistar; Seminal Vesicles; Serotonin; Serotonin Agents; Sexual Dysfunction, Physiological; Splanchnic Nerves; Sympatholytics | 1998 |
Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Clonidine; Dose-Response Relationship, Drug; Formaldehyde; Imipramine; Injections, Intraventricular; Male; Nociceptors; Pain; Pain Measurement; Prazosin; Rats; Rats, Wistar; Yohimbine | 2002 |
Adrenoceptor mechanisms underlying imipramine-induced memory deficits in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Imipramine; Male; Memory; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Yohimbine | 2003 |
Imipramine-induced antinociception in the formalin test. Receptor mechanisms involved and effect of swim stress.
Topics: Animals; Dose-Response Relationship, Drug; Imipramine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naloxone; Nociceptors; Pain; Pain Measurement; Prazosin; Stress, Physiological; Swimming; Yohimbine | 2003 |
Effects of imipramine on the expression and development of morphine dependence in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clonidine; Dose-Response Relationship, Drug; Imipramine; Injections, Subcutaneous; Male; Mice; Morphine; Morphine Dependence; Motor Activity; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Yohimbine | 2003 |
Pharmacological characterization of the presynaptic activity of Tityus serrulatus venom in the rat anococcygeus muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Carbachol; Cholinergic Antagonists; Electric Stimulation; Guanethidine; Imipramine; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Skeletal; Nitrergic Neurons; Phentolamine; Prazosin; Presynaptic Terminals; Rats; Rats, Wistar; Scorpion Venoms; Scorpions; Tetrodotoxin; Tyramine | 2003 |
Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Dopamine Antagonists; Drug Interactions; Fenclonine; Fluoxetine; Hexanes; Imipramine; Male; Mice; Motor Activity; Myristica; Plant Extracts; Prazosin; Seeds; Serotonin Antagonists; Sulpiride; Swimming | 2006 |
Involvement of dopamine D1 receptors and alpha1-adrenoceptors in the antidepressant-like effect of chlorpheniramine in the mouse tail suspension test.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Benzazepines; Chlorpheniramine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Hindlimb Suspension; Histamine H1 Antagonists; Imipramine; Male; Mice; Mice, Inbred ICR; Motor Activity; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D1; Time Factors | 2007 |
Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs.
Topics: Animals; Antidepressive Agents; Benzazepines; Biogenic Monoamines; Bupropion; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fenclonine; Fluoxetine; Hypericum; Imipramine; Immobility Response, Tonic; Locomotion; Male; Mice; Mice, Inbred Strains; Phloroglucinol; Plant Extracts; Prazosin; Rats; Rats, Wistar; Receptors, Catecholamine; Sulpiride; Vesicular Monoamine Transport Proteins; Yohimbine | 2012 |