imipramine has been researched along with naloxone in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (31.25) | 18.7374 |
| 1990's | 9 (18.75) | 18.2507 |
| 2000's | 14 (29.17) | 29.6817 |
| 2010's | 10 (20.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Celsen, B; Huppertz, A; Kuschinsky, K | 1 |
| Alvarez, L; Asher, K; Bergman, SA; Thut, PD; Wynn, RL | 1 |
| Martin, P; Massol, J; Puech, AJ | 1 |
| Ehrensing, RH; Kastin, AJ; McLean, JH; Olson, GA; Olson, RD; Pignatiello, MF | 1 |
| Ebert, DM; Giardina, WJ | 1 |
| de Ceballos, ML; de Felipe, MC; Fuentes, JA | 1 |
| Garcia, MC; Kenney, RM; McDonnell, SM | 1 |
| Reny-Palasse, V; Rips, R | 1 |
| Buéno, L; Fioramonti, J; Sorraing, JM | 1 |
| Paz, MM; Takahashi, RN | 1 |
| Caffrey, JL; Gaugl, JF; Wooldridge, CB | 1 |
| Bell, S; Jhamandas, K; Sutak, M | 1 |
| Colhoun, E; Dubas, T; Lundy, P; Parker, JM | 1 |
| Kamei, C; Shimomura, K; Ueki, S | 1 |
| Ciofalo, FR | 1 |
| Angioi, RM; Curreli, V; De Montis, GM; Devoto, P; Tagliamonte, A | 1 |
| De Montis, GM; Devoto, P; Tagliamonte, A | 1 |
| Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P | 1 |
| Bastide, P; Coudert, P; Rubat, C; Tronche, P | 1 |
| Fukase, H; Fukuzaki, K; Koja, T; Lukas, SE; Nagata, R | 1 |
| Atcheson, R; Lambert, DG; Rowbotham, DJ | 1 |
| Mendez, M; Miranda, HF; Pinardi, G; Sierralta, F | 1 |
| Besson, A; Eschalier, A; Fialip, J; Privat, AM | 1 |
| Miyata, K; Yamano, M; Yasuda, S; Yuki, H | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 1 |
| Sahebgharani, M; Shaverdian, S; Zarrindast, MR | 1 |
| Sahebgharani, M; Vousooghi, N; Zarrindast, MR | 1 |
4 review(s) available for imipramine and naloxone
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
44 other study(ies) available for imipramine and naloxone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Studies on dopamine kinetics in rat brain tissue under the influence of morphine.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Dopamine; Humans; Imipramine; In Vitro Techniques; Kinetics; Morphine; Morphine Dependence; Naloxone; Potassium; Rats; Sensory Receptor Cells; Stereotyped Behavior | 1975 |
Imipramine-fentanyl antinociception in a rabbit tooth pulp model.
Topics: Analgesics; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Electric Stimulation; Female; Fentanyl; Imipramine; Injections, Intravenous; Kinetics; Male; Morphine; Naloxone; Nociceptors; Rabbits; Respiration | 1991 |
Captopril as an antidepressant? Effects on the learned helplessness paradigm in rats.
Topics: Animals; Antidepressive Agents; Arousal; Avoidance Learning; Captopril; Dose-Response Relationship, Drug; Escape Reaction; Helplessness, Learned; Imipramine; Male; Motor Activity; Naloxone; Rats; Rats, Inbred Strains | 1990 |
MIF-1 is active in a chronic stress animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Imipramine; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Stress, Physiological | 1989 |
Positive effects of captopril in the behavioral despair swim test.
Topics: Animals; Arousal; Captopril; Dose-Response Relationship, Drug; Escape Reaction; Imipramine; Methamphetamine; Mianserin; Mice; Mice, Inbred Strains; Motivation; Naloxone; Swimming | 1989 |
Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin.
Topics: Amitriptyline; Animals; Antidepressive Agents; Dibenzazepines; Drug Tolerance; Endorphins; Fenclonine; Imipramine; Iprindole; Male; Methysergide; Mice; Mice, Inbred ICR; Naloxone; Pain; Protease Inhibitors; Serotonin | 1986 |
Pharmacological manipulation of sexual behaviour in stallions.
Topics: Animals; Clomipramine; Diazepam; Ejaculation; Fenclonine; Horses; Imipramine; Male; Naloxone; Penile Erection; Pituitary Hormone-Releasing Hormones; Sexual Behavior, Animal; Yohimbine | 1987 |
Potentiation by TRH of the effect of imipramine on the forced-swimming test.
Topics: Animals; Drug Synergism; Drug Tolerance; Imipramine; Male; Mice; Morphine; Naloxone; Phenoxybenzamine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Opioid; Swimming; Thyrotropin-Releasing Hormone; Yohimbine | 1985 |
Central and peripheral serotonergic control of forestomach motility in sheep.
Topics: Animals; Atropine; Electrophysiology; Female; Gastrointestinal Motility; Imipramine; Injections, Intravenous; Injections, Intraventricular; Methysergide; Naloxone; Receptors, Muscarinic; Receptors, Opioid; Serotonin; Serotonin Antagonists; Sheep; Stomach, Ruminant | 1985 |
Influence of naloxone on analgesic effects of antidepressants in mice.
Topics: Animals; Hot Temperature; Imipramine; Male; Mianserin; Mice; Mice, Inbred Strains; Naloxone; Nociceptors; Nomifensine; Thermoreceptors | 1987 |
Naloxone enhances myocardial responses to isoproterenol in dog isolated heart-lung.
Topics: Animals; Dogs; Female; Heart; Imipramine; In Vitro Techniques; Isoproterenol; Male; Naloxone | 1986 |
Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.
Topics: Animals; Atropine; Autonomic Nervous System; Diphenhydramine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Imipramine; Mecamylamine; Morphine; Morphine Dependence; Naloxone; Neurotransmitter Agents; Physostigmine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Substance Withdrawal Syndrome; Synaptic Transmission; Tolazoline | 1973 |
Investigation of mechanisms involved in toxic effects of narcotic analgesics.
Topics: Analgesics; Animals; Brain; Brain Chemistry; Catecholamines; Dextropropoxyphene; Drug Interactions; Female; Fenclonine; Heroin; Imipramine; Lethal Dose 50; Morphine; Naloxone; Narcotics; Norepinephrine; Pargyline; Rats; Reserpine; Tranylcypromine; Tyrosine | 1972 |
Significance of withdrawal jumping response in predicting physical dependence in mice.
Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imipramine; Male; Mephenesin; Methamphetamine; Mice; Morphine Dependence; Naloxone; Pentobarbital; Perphenazine; Phenytoin; Reserpine; Substance Withdrawal Syndrome | 1973 |
Methadone inhibition of 3H-5-hydroxytryptamine uptake by synaptosomes.
Topics: Animals; Brain; Centrifugation, Density Gradient; Cold Temperature; Dinitrophenols; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Kinetics; Male; Methadone; Monoamine Oxidase Inhibitors; Morphine; Naloxone; Ouabain; Potassium Chloride; Rabbits; Serotonin; Serotonin Antagonists; Sucrose; Synaptosomes; Tritium | 1974 |
In utero exposure to methadone produces a stable decrease of the cortex 5-HT transport system in rats.
Topics: Animals; Biological Transport; Cerebral Cortex; Female; Imipramine; Methadone; Naloxone; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Muscarinic; Receptors, Serotonin; Serotonin; Synaptosomes | 1983 |
Possible antidepressant activity of methadone.
Topics: Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Imipramine; In Vitro Techniques; Membranes; Methadone; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Serotonin | 1982 |
Implication of endogenous opioid system in the learned helplessness model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blepharoptosis; Citalopram; Clomipramine; Drug Interactions; Fluoxetine; Hypothermia; Imipramine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Models, Molecular; Motor Activity; Naloxone; Piperazines; Pyridazines; Reserpine; Structure-Activity Relationship; Swimming; Trazodone; Yohimbine | 1995 |
Effects of morphine, naloxone, buprenorphine, butorphanol, haloperidol and imipramine on morphine withdrawal signs in cynomolgus monkeys.
Topics: Animals; Behavior, Animal; Buprenorphine; Butorphanol; Haloperidol; Imipramine; Macaca fascicularis; Male; Morphine; Morphine Dependence; Naloxone; Psychotropic Drugs; Substance Withdrawal Syndrome | 1994 |
Fentanyl inhibits the uptake of [3H]noradrenaline in cultured neuronal cells.
Topics: Adrenal Gland Neoplasms; Animals; Dose-Response Relationship, Drug; Fentanyl; Humans; Imipramine; Morphine; Naloxone; Neuroblastoma; Neurons; Norepinephrine; Pheochromocytoma; Rats; Time Factors; Tumor Cells, Cultured | 1993 |
Interaction of opioids with antidepressant-induced antinociception.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Drug Combinations; Female; Imipramine; Male; Maprotiline; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Random Allocation; Selective Serotonin Reuptake Inhibitors; Zimeldine | 1995 |
Dopaminergic and opioidergic mediations of tricyclic antidepressants in the learned helplessness paradigm.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Desipramine; Dibenzocycloheptenes; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Escape Reaction; Haloperidol; Helplessness, Learned; Imipramine; Male; Motor Activity; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Wistar | 1999 |
Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Behavior, Animal; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Imipramine; Indomethacin; Interferon-alpha; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Time Factors | 2000 |
Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Imidazoles; Imipramine; Indoles; Isoindoles; Male; Mice; Naloxone; Organophosphorus Compounds; Receptors, Adrenergic, alpha-2; Yohimbine | 2000 |
Effect of imipramine on tolerance to morphine antinociception in the formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Disinfectants; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Formaldehyde; Imipramine; Injections, Intraperitoneal; Male; Mice; Morphine; Naloxone; Pain | 2000 |
Imipramine-induced antinociception in the formalin test. Receptor mechanisms involved and effect of swim stress.
Topics: Animals; Dose-Response Relationship, Drug; Imipramine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naloxone; Nociceptors; Pain; Pain Measurement; Prazosin; Stress, Physiological; Swimming; Yohimbine | 2003 |