idazoxan has been researched along with naloxone in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (28.85) | 18.7374 |
| 1990's | 19 (36.54) | 18.2507 |
| 2000's | 10 (19.23) | 29.6817 |
| 2010's | 8 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Griffin, IJ; Jackson, HC; Nutt, DJ | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Midgley, LP | 1 |
| Assenmacher, I; Barbanel, G; Gaillet, S; Malaval, F; Pelletier, G; Szafarczyk, A | 1 |
| Bianchi, G | 1 |
| Boublik, JH; Brown, MR; Hua, XY; Rivier, JE; Spicer, MA; Yaksh, TL | 1 |
| Clarke, RW; Ford, TW; Harris, J; Neal, RI; Taylor, JS | 1 |
| Connelly, CD; Hollingworth, RM; Orr, N; Raffa, RB | 1 |
| al-Damluji, S; Besser, M; Bouloux, P; White, A | 1 |
| Couture, R; Dorais, J; Laneuville, O | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Simonato, M; Spalluto, P; Tanganelli, S; Tomasini, C | 1 |
| Clarke, RW; Ford, TW; Taylor, JS | 2 |
| Adamson, P; Brammer, MJ; Campbell, IC; Mantzourides, T; Xiang, JZ | 1 |
| Couture, R; Laneuville, O; Reader, TA | 1 |
| Berthold, H; Engel, G; Fozard, JR | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Mantzouridis, T; Xiang, JZ | 1 |
| Aston-Jones, G; Ennis, M | 1 |
| Puurunen, J | 1 |
| Agnati, LF; Fuxe, K; Härfstrand, A; Kalia, M | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Baxter, AJ; Read, NW; Welch, IM | 1 |
| Dean, HG; Furman, BL; Sidey, FM | 1 |
| Lester, BR; Sun, Z; Wilcox, GL; Wu, HH | 1 |
| Beleslin, DB; Jovanović-Mićić, D; Samardzić, R | 1 |
| Anton, F; Dubner, R; Kenshalo, DR; Thomas, DA; Williams, GM | 1 |
| Agnati, LF; Frasoldati, A; Grimaldi, R; Marrama, P; Pich, EM; Zini, I | 1 |
| Bouaziz, H; Eisenach, JC; Hood, DD; Tong, C; Yoon, Y | 1 |
| Davies, A; Gent, JP; Goodchild, CS; Guo, Z | 1 |
| Feigenbaum, JJ; Howard, SG | 1 |
| Carón, RW; Deis, RP; Salicioni, AM | 1 |
| Mason, R; Mundey, MK; Wilson, VG | 1 |
| Gray, AM; Nevinson, MJ; Sewell, RD | 1 |
| Fukuhara, N; Ishikawa, T; Kinoshita, H; Nakanishi, O; Xiong, L | 1 |
| Alvarez, I; Andreu, F; Buxens, J; Colombo, M; Dordal, A; Farré, AJ; Fort, M; Gutiérrez, B | 1 |
| Clarke, RW; Eves, S; Harris, J; Peachey, JE; Stuart, E | 1 |
| Aricioglu, F; Dulger, G; Ercil, E | 1 |
| Aricioglu, F; Utkan, T | 1 |
| Galligan, JJ; Ren, J | 1 |
| Grandoso, L; Pineda, J; Torrecilla, M; Ugedo, L | 1 |
| Cardinaletti, C; Carrieri, A; Gentili, F; Ghelfi, F; Mattioli, L; Perfumi, M; Pigini, M; Vesprini, C | 1 |
| Berrocoso, E; Mico, JA | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Bhalla, S; Gulati, A; Rapolaviciute, V | 1 |
| Andurkar, SV; Gulati, A | 1 |
| Athayde, ML; Boligon, AA; Bonacorso, HG; Calixto, JB; Ferreira, J; Machado, P; Martins, MA; Oliveira, SM; Rosa, F; Rossato, MF; Rubin, MA; Silva, CR; Tonello, R; Trevisan, G; Walker, CI; Zanatta, N | 1 |
| Caselli, G; Ferrari, F; Lanza, M; Menghetti, I; Tremolada, D | 1 |
| Berrocoso, E; Borges, GDS; Mico, JA; Torres-Sanchez, S | 1 |
| Araki, M; Nakamura, S; Nonaka, T; Yamamoto, T; Yoshida, K | 1 |
1 trial(s) available for idazoxan and naloxone
| Article | Year |
|---|---|
The role of alpha-2-adrenoceptors in the control of ACTH secretion; interaction with the opioid system.
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Blood Pressure; Catecholamines; Dioxanes; Dioxins; Double-Blind Method; Heart Rate; Humans; Hydrocortisone; Idazoxan; Male; Naloxone; Random Allocation; Receptors, Adrenergic, alpha; Receptors, Opioid | 1990 |
51 other study(ies) available for idazoxan and naloxone
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Endogenous opioids may be involved in idazoxan-induced food intake.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Eating; Endorphins; Idazoxan; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1992 |
Characterization of phencyclidine-induced effects on neuropeptide Y systems in the rat caudate-putamen.
Topics: 4-Aminobutyrate Transaminase; Adrenergic beta-Antagonists; Aminocaproates; Aminooxyacetic Acid; Animals; Benzazepines; Carbazoles; Corpus Striatum; Dioxanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Idazoxan; Male; Naloxone; Neuropeptide Y; Phencyclidine; Prazosin; Psychotropic Drugs; Putamen; Pyrimidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors; Vigabatrin | 1992 |
Inhibitory interactions between alpha 2-adrenergic and opoid but not NPY mechanisms controlling the CRF-ACTH axis in the rat.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Dioxanes; Female; Hormones; Hypothalamo-Hypophyseal System; Idazoxan; Injections, Intraventricular; Naloxone; Neuropeptide Y; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Drug; Receptors, Opioid; Stress, Physiological | 1991 |
Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Benzomorphans; Dioxanes; Diuresis; Dose-Response Relationship, Drug; Idazoxan; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Injections, Spinal; Male; Motor Activity; Naloxone; Neuropeptide Y; Pain; Parasympathomimetics; Peptide Fragments; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Prolonged inhibition of a spinal reflex after intense stimulation of distant peripheral nerves in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Median Nerve; Naloxone; Peroneal Nerve; Rabbits; Reflex; Spinal Cord; Time Factors | 1991 |
XAMI and DCDM, agonists at cAMP-associated octopamine receptors in cockroach nerve cord, produce centrally mediated antinociception in mice.
Topics: Adenylyl Cyclase Inhibitors; Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Chlorphenamidine; Cyclic AMP; Dioxanes; Drug Interactions; Idazoxan; Imidazoles; In Vitro Techniques; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Naloxone; Octopamine; Periplaneta; Phenylephrine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Biogenic Amine; Yohimbine | 1991 |
Characterization of the effects produced by neurokinins and three agonists selective for neurokinin receptor subtypes in a spinal nociceptive reflex of the rat.
Topics: Adrenalectomy; Animals; Bradykinin; Dioxanes; Hot Temperature; Idazoxan; Male; Naloxone; Neurokinin A; Neurokinin B; Neuropeptides; Nociceptors; Pain Measurement; Peptide Fragments; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1988 |
Changes in cortical acetylcholine and gamma-aminobutyric acid outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors.
Topics: Acetylcholine; Animals; Clonidine; Dioxanes; Female; gamma-Aminobutyric Acid; Guinea Pigs; Idazoxan; Locus Coeruleus; Male; Morphine; Naloxone; Prazosin; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome | 1989 |
Activation by high intensity peripheral nerve stimulation of adrenergic and opioidergic inhibition of a spinal reflex in the decerebrated rabbit.
Topics: Action Potentials; Animals; Decerebrate State; Dioxanes; Dioxins; Electric Stimulation; Female; Idazoxan; Male; Naloxone; Peripheral Nerves; Rabbits; Receptors, Adrenergic, alpha; Receptors, Opioid; Reflex; Spinal Cord | 1989 |
Presynaptic alpha 2-adrenoceptor and kappa-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzofurans; Calcium; Calcium Channels; Clonidine; Dioxanes; Fura-2; Idazoxan; In Vitro Techniques; Male; Mollusk Venoms; Naloxone; Neurons; Nifedipine; omega-Conotoxin GVIA; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptosomes | 1989 |
Intrathecal bradykinin acts presynaptically on spinal noradrenergic terminals to produce antinociception in the rat.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Biogenic Monoamines; Bradykinin; Catecholamines; Catheters, Indwelling; Dioxanes; Endorphins; Hydroxydopamines; Idazoxan; Injections, Spinal; Kallidin; Male; Naloxone; Oxidopamine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord; Yohimbine | 1989 |
5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Buspirone; Dioxanes; Female; Fenclonine; Idazoxan; Indoles; Mice; Morphine Dependence; Naloxone; Prazosin; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Caffeine; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Fluorescent Dyes; Fura-2; Homeostasis; Idazoxan; Male; Naloxone; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Synaptosomes | 1989 |
GABA-mediated inhibition of locus coeruleus from the dorsomedial rostral medulla.
Topics: Animals; Bicuculline; Dioxanes; Evoked Potentials; gamma-Aminobutyric Acid; Idazoxan; Iontophoresis; Locus Coeruleus; Male; Medulla Oblongata; Naloxone; Neural Inhibition; Picrotoxin; Rats; Rats, Inbred Strains | 1989 |
Role of putative neurotransmitters in the central gastric antisecretory effect of prostaglandin E2 in rats.
Topics: 5,6-Dihydroxytryptamine; Adrenergic alpha-Antagonists; Animals; Dinoprostone; Dioxanes; Female; Fenclonine; Gastric Juice; Histamine Antagonists; Hydroxydopamines; Idazoxan; Injections, Intraventricular; Male; Naloxone; Neurotransmitter Agents; Oxidopamine; Phentolamine; Propranolol; Prostaglandins E; Rats; Rats, Inbred Strains; Sulpiride; Theophylline | 1985 |
Somatostatin induced apnoea: prevention by central and peripheral administration of the opiate receptor blocking agent naloxone.
Topics: Animals; Apnea; Brain; Cisterna Magna; Dioxanes; Idazoxan; Injections; Injections, Intravenous; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Respiration; Somatostatin | 1985 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Decerebrate State; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Male; Naloxone; Norepinephrine; Rabbits; Reflex; Sural Nerve | 1988 |
Effect of naloxone, domperidone and idazoxan on the delay in gastric emptying induced by ileal lipid.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Dioxanes; Domperidone; Emulsions; Gastric Emptying; Humans; Idazoxan; Ileum; Intubation, Gastrointestinal; Lipid Metabolism; Male; Naloxone | 1987 |
Role of the adrenal medulla in stress-induced hyperinsulinaemia in normal mice and in mice infected with Bordetella pertussis or treated with pertussis toxin.
Topics: Adrenal Medulla; Animals; Dioxanes; Ether; Female; Hexamethonium Compounds; Idazoxan; Insulin; Mice; Naloxone; Pertussis Toxin; Propranolol; Rats; Rats, Inbred Strains; Stress, Physiological; Virulence Factors, Bordetella; Whooping Cough | 1988 |
Antinociception following implantation of mouse B16 melanoma cells in mouse and rat spinal cord.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Catecholamines; Cell Transplantation; Desipramine; Dioxanes; Idazoxan; Injections, Spinal; Male; Melanoma, Experimental; Mice; Mice, Inbred ICR; Morphine; Naloxone; Neoplasm Transplantation; Nociceptors; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P; Transplantation, Heterotopic | 1994 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Dioxanes; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Hemicholinium 3; Idazoxan; Injections, Intraventricular; Male; Mecamylamine; Methyltyrosines; Methysergide; Naloxone; Oxidopamine; Prazosin; Reserpine; Tolazoline; Tyrosine 3-Monooxygenase; Vomiting; Yohimbine | 1995 |
Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Electrophysiology; Hot Temperature; Idazoxan; Macaca fascicularis; Macaca mulatta; Male; Medulla Oblongata; Microinjections; Naloxone; Norepinephrine; Pain; Physical Stimulation; Receptors, Opioid | 1993 |
Involvement of alpha 2-receptors in the analgesia induced by transient forebrain ischemia in rats.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain; Carotid Artery, Common; Clonidine; Dioxanes; Endorphins; Idazoxan; Ischemic Attack, Transient; Male; Methysergide; Naloxone; Norepinephrine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Yohimbine | 1993 |
Intravenous opioids stimulate norepinephrine and acetylcholine release in spinal cord dorsal horn. Systematic studies in sheep and an observation in a human.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Dialysis; Dioxanes; Dopamine; Female; Fentanyl; Humans; Idazoxan; Imidazoles; Injections, Intravenous; Male; Microchemistry; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-2; Sheep; Spinal Cord; Stimulation, Chemical | 1996 |
Antinociceptive actions of intrathecal xylazine: interactions with spinal cord opioid pathways.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Fentanyl; Idazoxan; Imidazoles; Male; Naloxone; Nociceptors; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Xylazine | 1996 |
Naloxone reverses the inhibitory effect of gamma-hydroxybutyrate on central DA release in vivo in awake animals: a microdialysis study.
Topics: 5-Hydroxytryptophan; Animals; Dopamine; Dose-Response Relationship, Drug; Idazoxan; Male; Microdialysis; Naloxone; Rats; Rats, Sprague-Dawley; Sodium Oxybate | 1996 |
Participation of both adrenergic and opioidergic systems in the negative feedback of adrenal progesterone on LH secretion.
Topics: Adrenal Glands; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Estradiol; Feedback; Female; Hormone Antagonists; Idazoxan; Luteinizing Hormone; Metoprolol; Mifepristone; Naloxone; Ovariectomy; Prazosin; Progesterone; Propanolamines; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Opioid | 1997 |
Selective potentiation by ouabain of naloxone-induced withdrawal contractions of isolated guinea-pig ileum following acute exposure to morphine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Ouabain; Receptors, Adrenergic, alpha-2; Sodium-Potassium-Exchanging ATPase; Substance Withdrawal Syndrome | 1998 |
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Central noradrenergic mediation of nitrous oxide-induced analgesia in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Drug Synergism; Idazoxan; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Nitrous Oxide; Rats; Rats, Wistar; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Receptors, Presynaptic; Spinal Cord; Synaptic Transmission | 1998 |
Pharmacology of cizolirtine: a new analgesic agent.
Topics: Analgesics; Animals; Desipramine; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Idazoxan; Male; Mice; Naloxone; Pyrazoles; Rats; Rats, Wistar | 2000 |
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Decerebrate State; Dexmedetomidine; Dizocilpine Maleate; Drug Synergism; Efferent Pathways; Electric Stimulation; Excitatory Amino Acid Antagonists; Idazoxan; Imidazoles; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Neurons, Afferent; Rabbits; Reflex; Skin; Sural Nerve; Tarsus, Animal | 2002 |
Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Idazoxan; Ileum; Male; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Yohimbine | 2003 |
Inhibitory effect of harmane on morphine-dependent Guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Guinea Pigs; Harmine; Idazoxan; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Yohimbine | 2003 |
Dynamics of fast synaptic excitation during trains of stimulation in myenteric neurons of guinea-pig ileum.
Topics: Acetylcholine; Action Potentials; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Animals; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Estriol; Excitatory Postsynaptic Potentials; GABA Antagonists; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Iontophoresis; Male; Mecamylamine; Myenteric Plexus; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurons; Nicotinic Antagonists; Peptides; Picrotoxin; Piperazines; Platelet Aggregation Inhibitors; Pyridoxal Phosphate; Serotonin 5-HT1 Receptor Antagonists; Theophylline; Time Factors | 2005 |
alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Methiothepin; Naloxone; Narcotic Antagonists; Neurons; Norepinephrine; Oxazines; Piperazines; Piperidines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 2005 |
Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Benzofurans; CHO Cells; Cricetinae; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Models, Molecular; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Opioid, mu; Yohimbine | 2006 |
In vivo effect of venlafaxine on locus coeruleus neurons: role of opioid, alpha(2)-adrenergic, and 5-hydroxytryptamine(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Cyclohexanols; Idazoxan; Locus Coeruleus; Male; Naloxone; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Serotonin; Venlafaxine Hydrochloride | 2007 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine | 2011 |
Assessment of the analgesic effect of centhaquin in mouse tail flick and hot-plate tests.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Antihypertensive Agents; Body Temperature; Drug Interactions; Endothelin A Receptor Antagonists; Hot Temperature; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Piperazines; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Yohimbine | 2011 |
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Benzofurans; Diterpenes; Drug Administration Routes; Drug Evaluation, Preclinical; Idazoxan; Male; Mice; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrazoles; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Tritium; TRPV Cation Channels | 2013 |
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Binding Sites; Drug Synergism; Female; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Morphine; Naloxone; Narcotic Antagonists; Pain, Postoperative; Quinazolines; Rats, Sprague-Dawley; Yohimbine | 2014 |
Opioid and noradrenergic contributions of tapentadol to the inhibition of locus coeruleus neurons in the streptozotocin rat model of polyneuropathic pain.
Topics: Action Potentials; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Idazoxan; Locus Coeruleus; Male; Naloxone; Neural Inhibition; Neurons; Pain Measurement; Rats; Tapentadol | 2018 |
Microinjection of 26RFa, an endogenous ligand for the glutamine RF-amide peptide receptor (QRFP receptor), into the rostral ventromedial medulla (RVM), locus coelureus (LC), and periaqueductal grey (PAG) produces an analgesic effect in rats.
Topics: Analgesics; Animals; Drug Antagonism; Idazoxan; Locus Coeruleus; Male; Microinjections; Naloxone; Neuropeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled | 2019 |