hydrazine and guanine
hydrazine has been researched along with guanine in 50 studies
Research
Studies (50)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (70.00) | 18.7374 |
| 1990's | 4 (8.00) | 18.2507 |
| 2000's | 6 (12.00) | 29.6817 |
| 2010's | 5 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gilbert, W; Maxam, AM | 1 |
| Schleich, HG; Wintermeyer, W; Zachau, HG | 2 |
| Autrup, H; Harris, CC; McDowell, EM; Schafer, P; Stoner, GD; Trump, BF | 1 |
| Likhachev, AJ; Margison, GP; Montesano, R | 1 |
| Pratviel, G; Sartorelli, AC; Shyam, K | 1 |
| Lambert, CE; Shank, RC | 1 |
| Shank, RC | 3 |
| Bosan, WS; Gaworski, CL; MacEwen, JD; Newberne, PM; Shank, RC | 1 |
| Bosan, WS; Lambert, CE; Shank, RC | 2 |
| Loth, L; Mihich, E; Mulhern, AI; Simpson, CL | 1 |
| Hakala, MT | 1 |
| Küchler, C; Küchler, W; Schulze, W | 1 |
| Hawks, A; Magee, PN | 1 |
| Pine, MJ | 1 |
| Cashmore, AR; Petersen, GB | 1 |
| Hawks, A; Magee, PN; Swann, PF | 1 |
| Hakala, MT; Weiss, L | 1 |
| Aviado, M; Ruiz, R | 1 |
| Kreis, W | 1 |
| Ehrke, MJ; Mihich, E; Soucek, J | 1 |
| Mutschler, E; Springer, J; Wassermann, O | 1 |
| Chan, GW; Colwell, WT; Henry, DW; Horner, JK; Parkhurst, RM | 1 |
| Bernhard, HV; Kreis, W; Piepho, SB | 1 |
| Ellery, BW; Symons, RH | 1 |
| Sartorelli, AC; Tsunamura, S | 1 |
| Jaffe, JJ; Waterbury, LD | 1 |
| Roy, JE; Roy, KL | 1 |
| Paz-Neri, LL; Quintero-Ruiz, A; Villa-Treviño, S | 1 |
| Bosan, WS; Shank, RC | 1 |
| Barrows, LR; Becker, RA; Shank, RC | 1 |
| Mathison, BH; Murphy, SE; Shank, RC | 1 |
| Leakakos, T; Shank, RC | 1 |
| Baan, RA; de Groot, AJ; Eberle-Adamkiewicz, G; Rajewsky, MF; Steenwinkel, MJ; Thomale, J; van Delft, JH; van Zeeland, AA | 1 |
| Fiala, ES; Sodum, RS | 1 |
| Brenk, R; Garcia, GA; Gerber, HD; Grädler, U; Klebe, G; Naerum, L; Reuter, K; Stubbs, MT | 1 |
| EHMER, A; JAHR, K; KUSCHINSKY, G; LUELLMANN, H; MUTSCHLER, E; WOLLERT, U | 1 |
| Daft, JR; Epperson, JD; Gannett, PM; Greenbaum, NL; Heavner, S; Shaughnessy, KH | 1 |
| Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K | 1 |
| Baumann, RP; Penketh, PG; Sartorelli, AC; Seow, HA; Shyam, K | 1 |
| Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Seow, HA; Shyam, K | 1 |
| El-Gendy, Bel-D; Ghiviriga, I; Katritzky, AR; Steel, PJ | 1 |
| Gaffney, BL; Hou, X; Jones, RA; Wang, G | 1 |
| Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, YL | 1 |
| Baumann, RP; Liu, MC; Luo, MZ; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R | 1 |
| Baumann, RP; Ishiguro, K; Patridge, EV; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R | 1 |
| Baumann, RP; Ishiguro, K; Patridge, E; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R | 1 |
Reviews
1 review(s) available for hydrazine and guanine
| Article | Year |
|---|---|
Toxicity-induced aberrant methylation of DNA and its repair.
Topics: Alkylation; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; DNA; DNA Repair; Formaldehyde; Guanine; Hydrazines; Methylation; Methylhydrazines; S-Adenosylmethionine | 1984 |
Other Studies
49 other study(ies) available for hydrazine and guanine
| Article | Year |
|---|---|
A new method for sequencing DNA.
Topics: Adenine; Base Sequence; Biochemical Phenomena; Biochemistry; Cytosine; DNA; DNA Restriction Enzymes; Guanine; Hydrazines; Methods; Nucleic Acid Hybridization; Thymine | 1977 |
Replacement of wybutine by hydrazines and its effect on the active conformation of yeast tRNAPhe.
Topics: Escherichia coli; Guanine; Hydrazines; Kinetics; Phenylalanine; Phenylalanine-tRNA Ligase; Poly U; Purinones; Ribosomes; RNA, Transfer; Saccharomyces cerevisiae | 1978 |
Incorporation of amines or hydrazines into tRNA replacing wybutine or dihydrouracil.
Topics: Amines; Borohydrides; Guanine; Hydrazines; Kinetics; Oxidation-Reduction; Phenylalanine; Purinones; RNA, Transfer; Uracil | 1979 |
Metabolism of dimethylnitrosamine and 1,2-dimethylhydrazine in cultured human bronchi.
Topics: Biotransformation; Bronchi; Culture Techniques; Dimethylhydrazines; Dimethylnitrosamine; DNA; Guanine; Humans; Hydrazines; Methylation; Mutation; Nitrosamines; Protein Binding | 1977 |
Alkylated purines in the DNA of various rat tissues after administration of 1,2-dimethylhydrazine.
Topics: Animals; Colon; Dimethylhydrazines; DNA; Guanine; Hydrazines; Liver; Male; Methylation; Organ Specificity; Rats | 1977 |
Cytotoxic and DNA-damaging effects of 1,2-bis(sulfonyl)hydrazines on human cells of the Mer+ and Mer- phenotype.
Topics: Alkylating Agents; Alkylation; Colonic Neoplasms; DNA Damage; DNA Repair; DNA, Neoplasm; Guanine; Humans; Hydrazines; Methylation; Methyltransferases; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Sulfones; Tumor Cells, Cultured | 1989 |
Role of formaldehyde hydrazone and catalase in hydrazine-induced methylation of DNA guanine.
Topics: Amines; Animals; Catalase; DNA; Formaldehyde; Guanine; Heterocyclic Compounds; Hydrazines; Hydrazones; Magnetic Resonance Spectroscopy; Male; Methimazole; Methylation; Rats; Rats, Inbred Strains | 1988 |
Comparative study on the indirect methylation of liver DNA guanine by the 1-carbon pool in hepatotoxicity.
Topics: Animals; Chemical Phenomena; Chemistry; Cricetinae; DNA; Formaldehyde; Guanine; Hydrazines; Liver; Liver Neoplasms, Experimental; Male; Mesocricetus; Methylation; Mice; Species Specificity | 1987 |
Methylation of DNA guanine during the course of induction of liver cancer in hamsters by hydrazine or dimethylnitrosamine.
Topics: Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; Guanine; Hydrazines; Liver; Liver Neoplasms, Experimental; Male; Mesocricetus; Methylation; Tissue Distribution | 1987 |
The role of formaldehyde in hydrazine-induced methylation of liver DNA guanine.
Topics: Aldehydes; Animals; Cricetinae; Cytosol; DNA; Formaldehyde; Guanine; Hydrazines; Liver; Male; Mesocricetus; Methylation; Microsomes, Liver | 1986 |
Tetraformyltrisazine and hydrazine-induced methylation of liver DNA guanine.
Topics: Alkylating Agents; Animals; DNA; Dose-Response Relationship, Drug; Drug Combinations; Formaldehyde; Guanine; Heterocyclic Compounds; Hydrazines; Liver; Male; Methylation; Rats | 1986 |
Toxic and patologic effects of 4,4'-diacetyl-diphenyl-urea-bis(guanylhydrazone), a new antileukemic agent.
Topics: Alopecia; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dogs; Drug Eruptions; Guanine; Haplorhini; Hydrazines; Hypoglycemia; Injections, Intravenous; Leukemia, Experimental; Mice; Paralysis; Rabbits; Rats; Urea | 1969 |
Uptake and distribution of 4,4'-diacetyl-diphenyl-urea-bis-guanylhydrazone in sensitive and resistant sarcoma 180 cells in vitro.
Topics: Acetamides; Aldehydes; Anilides; Animals; Azo Compounds; Biological Transport; Carbon Isotopes; Cell Fractionation; Cell Line; Cell Nucleus; Cerebrosides; Choline; Dinitrophenols; Drug Synergism; Guanine; Hydrazines; Hydrochloric Acid; Imidazoles; Iodoacetates; Kinetics; Microsomes; Mitochondria; Mutation; Phenazines; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Polyamines; Sarcoma 180; Sodium Hydroxide; Spermine; Sphingomyelins; Temperature; Thermodynamics; Urea; Vincristine | 1971 |
Antiviral effect of methylglyoxal-bis-guanylhydrazone.
Topics: Animals; Antiviral Agents; Chick Embryo; Culture Techniques; Cytopathogenic Effect, Viral; Extraembryonic Membranes; Guanine; Hemagglutination; Hemagglutinins, Viral; Herpesviridae; Hydrazines; Mice; Newcastle disease virus; Vaccinia virus | 1968 |
The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine.
Topics: Alkylation; Animals; Bile; Carbon Dioxide; Colon; Dimethylhydrazines; Female; Guanine; Hydrazines; Liver; Male; Mice; Monomethylhydrazine; Nucleic Acids; Rats | 1974 |
Studies on the antimicrobial action of terephthalanilide and related drugs.
Topics: Amino Acids; Anilides; Antiprotozoal Agents; Bacterial Proteins; Carbon Isotopes; Cell Membrane Permeability; Cell-Free System; Chloramphenicol; Chlorine; Dinitrophenols; Escherichia coli; Guanine; Hydrazines; Imidazoles; Isoleucine; Lipids; Oxygen Consumption; Peptide Biosynthesis; Phenylalanine; Protein Binding; Ribosomes; RNA, Bacterial; RNA, Transfer; Spermine; Stilbamidines; Streptomycin; Thiosemicarbazones; Trypanosoma | 1968 |
The degradation of DNA by hydrazine: a critical study of the suitability of the reaction for the quantitative determination of purine nucleotide sequences.
Topics: Adenine; Adenine Nucleotides; Aldehydes; Animals; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Paper; Cytosine Nucleotides; DNA; DNA, Bacterial; Escherichia coli; Guanine; Hydrazines; Nucleotides; Pentoses; Phosphates; Purines; Temperature; Thymus Gland; Time Factors | 1969 |
Probable methylation of nucleic acids of mouse colon by 1,2-dimethylhydrazine in vivo.
Topics: Adenine; Alkylating Agents; Animals; Carbon Isotopes; Carcinogens; Chromatography, Ion Exchange; Colon; DNA; Female; Fossil Fuels; Guanine; Hydrazines; Liver; Methylation; Mice; Mice, Inbred Strains; Nucleic Acids; RNA | 1972 |
The anionic nature of sarcoma 180 cell surfaces, and sensitivity to 4,4'-diacetyldiphenylurea-bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line; Cell Membrane; Depression, Chemical; Electrophoresis; Guanine; Hydrazines; In Vitro Techniques; Membrane Potentials; Mice; Neuraminidase; Ribonucleases; Sarcoma 180; Surface Properties; Urea | 1971 |
Pharmacology of new antimalarial drugs: three guanylhydrazones.
Topics: Animals; Antimalarials; Aorta; Arrhythmias, Cardiac; Benzophenones; Blood Pressure; Chloroform; Dogs; Electrocardiography; Guanine; Hydrazines; Lung Compliance; Male; Membrane Potentials; Mice; Muscle Contraction; Pulmonary Artery; Rats; Vascular Resistance | 1970 |
Metabolism of an antineoplastic methylhydrazine derivative in a P815 mouse neoplasm.
Topics: Adenine; Animals; Antineoplastic Agents; Benzoates; Carbon Isotopes; Cell Line; Chromatography, Paper; Chromatography, Thin Layer; Cytoplasm; Cytosine; Female; Guanine; Hydrazines; Male; Methionine; Mice; Neoplasms, Experimental; RNA, Neoplasm; Thymine; Tritium | 1970 |
Effects of 4,4'-diacetyldiphenylurea-bis-(guanylhydrazone) on the incorporation of precursors into nucleic acid and protein of leukemia L1210.
Topics: Animals; Carbon Isotopes; Culture Techniques; Depression, Chemical; DNA Nucleotidyltransferases; DNA, Neoplasm; Guanine; Hydrazines; Injections, Intraperitoneal; Leukemia L1210; Mice; Neoplasm Proteins; Phenylalanine; RNA, Neoplasm; Thymidine; Urea; Uridine | 1970 |
Guanylhydrazones, another class of monoamine oxidase inhibitors.
Topics: Animals; Chemical Phenomena; Chemistry; Guanine; Guinea Pigs; Hydrazines; In Vitro Techniques; Iproniazid; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxygen Consumption; Serotonin; Tyramine | 1970 |
Preparation and antimalarial activity of compounds related to dypnone guanylhydrazone.
Topics: Animals; Antimalarials; Guanine; Hydrazines; Mice | 1971 |
Studies on the metabolic fate of the C14 labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia.
Topics: Adenine; Alkylation; Animals; Carbon Isotopes; DNA; Formates; Guanine; Hydrazines; Hypoxanthines; Leukemia, Experimental; Mice | 1966 |
Loss of adenine during the hydrazine degradation of deoxyribonucleic acid.
Topics: Adenine; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Paper; Cytosine; DNA; Guanine; Hydrazines; Hydroxides; Pyrimidines; Temperature; Thymine | 1966 |
Studies on the biochemical mode of action of a cytotoxic methylhydrazine derivative, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide.
Topics: Adenine; Amines; Animals; Antineoplastic Agents; Carbon Isotopes; DNA; Formates; Guanine; Hydrazines; Imidazoles; Leucine; Lymphoma; Male; Mice; Neoplasms, Experimental; Nucleosides; Nucleotides; Orotic Acid; Protein Biosynthesis; Purines; RNA; Thymidine; Thymidine Kinase; Tritium | 1966 |
Comparative effects of methylglyoxal-bis (guanylhydrazone), phenformin, and insulin upon the metabolism of glucose and acetate by rat epididymal fat pads in vitro.
Topics: Acetates; Adipose Tissue; Animals; Carbon Isotopes; Epididymis; Glucose; Guanine; Hydrazines; In Vitro Techniques; Insulin; Male; Mice; Phenformin; Rats | 1967 |
The mechanism and specificity of guanine deaminase.
Topics: Aminohydrolases; Animals; Azaguanine; Chemical Phenomena; Chemistry; Chemistry, Organic; Chlorine; Enzymes; Fishes; Guanine; Hydrazines; Kinetics; Organic Chemistry Phenomena; Purines; Spectrophotometry | 1967 |
Indirect alkylation of CBA mouse liver DNA and RNA by hydrazine in vivo. A possible mechanism of action as a carcinogen.
Topics: Alkylating Agents; Animals; Carcinogens; DNA; Guanine; Hydrazines; Liver; Male; Methylation; Mice; Mice, Inbred CBA; RNA | 1981 |
Methylation of liver DNA guanine in hamsters given hydrazine.
Topics: Animals; Cricetinae; DNA; Dose-Response Relationship, Drug; Glutathione; Guanine; Hydrazines; Liver; Male; Mesocricetus; Methylation; Monomethylhydrazine; S-Adenosylmethionine; Time Factors | 1983 |
Evidence for indirect genetic damage as methylation of DNA guanine in response to cytotoxicity.
Topics: Animals; Carcinogens; DNA; Dose-Response Relationship, Drug; Guanine; Guinea Pigs; Hydrazines; Liver; Methylation; Mice; Rats; Rats, Inbred Strains | 1983 |
Methylation of liver DNA guanine in hydrazine hepatotoxicity: dose-response and kinetic characteristics of 7-methylguanine and O6-methylguanine formation and persistence in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; DNA; Dose-Response Relationship, Drug; Guanine; Hydrazines; Kinetics; Liver; Male; Methylation; Rats | 1981 |
Hydralazine and other hydrazine derivatives and the formation of DNA adducts.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; DNA; Dose-Response Relationship, Drug; Formaldehyde; Guanine; Hydralazine; Hydrazines; Liver; Male; Methylation; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley | 1994 |
Hydrazine genotoxicity in the neonatal rat.
Topics: Animals; Animals, Newborn; Base Sequence; Blotting, Southern; Chromatography, High Pressure Liquid; DNA; Formaldehyde; Guanine; Hydrazines; Liver; Molecular Sequence Data; Rats; Rats, Sprague-Dawley | 1994 |
Determination of N7- and O6-methylguanine in rat liver DNA after oral exposure to hydrazine by use of immunochemical and electrochemical detection methods.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; Electrochemistry; Guanine; Hydrazines; Immunochemistry; Liver; Rats; Rats, Wistar | 1997 |
N2-amination of guanine to 2-hydrazinohypoxanthine, a novel in vivo nucleic acid modification produced by the hepatocarcinogen 2-nitropropane.
Topics: Amination; Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; Guanine; Hydrazines; Hypoxanthines; Liver Neoplasms, Experimental; Male; Nitroparaffins; Nucleic Acids; Propane; Rats; Rats, Inbred F344; RNA, Messenger; Spectrophotometry, Ultraviolet | 1998 |
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.
Topics: Binding Sites; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Databases, Factual; Enzyme Inhibitors; Guanine; Hydrazines; Ligands; Models, Molecular; Molecular Conformation; Pentosyltransferases; Piperidines; Pterins; Pyrazoles; Pyridazines; Quantum Theory; Structure-Activity Relationship; Zymomonas | 2003 |
[ON THE CARDIAC EFFECTS OF SIMPLE BISGUANYL HYDRAZONES].
Topics: Animals; Guanine; Guinea Pigs; Heart; Hydrazines; Hydrazones; Ketones; Pharmacology; Rats; Research | 1964 |
Synthesis, properties, and NMR studies of a C8-phenylguanine modified oligonucleotide that preferentially adopts the Z DNA conformation.
Topics: Base Pairing; Circular Dichroism; Deoxyguanosine; DNA, Z-Form; Guanine; Hydrazines; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Protons; Temperature | 2003 |
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
Topics: Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Blotting, Western; Cell Line; Cell Line, Tumor; Disease Progression; DNA Methylation; DNA, Complementary; Dose-Response Relationship, Drug; Gene Silencing; Glycerol; Guanine; Hematopoietic Stem Cells; Hydrazines; Inhibitory Concentration 50; Mice; Models, Chemical; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Sulfonamides; Transfection; Tumor Suppressor Protein p53 | 2005 |
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Drug Synergism; Guanine; HL-60 Cells; Humans; Hydrazines; Isocyanates; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Sulfonamides; Transfection | 2005 |
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cross-Linking Reagents; Cytosine; DNA; Ethane; Guanine; HL-60 Cells; Humans; Hydrazines; Leukemia; Mice; Sulfonamides; U937 Cells | 2008 |
Tautomerism of guanidines studied by (15)N NMR: 2-hydrazono-3-phenylquinazolin-4(3H)-ones and related compounds.
Topics: Analgesics; Anti-Inflammatory Agents; Benzimidazoles; Crystallography, X-Ray; Drug Discovery; Guanine; Hydrazines; Isomerism; Magnetic Resonance Spectroscopy; Pyrimidines; Quinazolinones | 2009 |
Preparation of DNA and RNA fragments containing guanine N(2)-thioalkyl tethers.
Topics: Dicarboxylic Acids; Disulfides; DNA; Guanine; Hydrazines; Organophosphorus Compounds; RNA; Sulfhydryl Compounds | 2010 |
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Guanine; Humans; Hydrazines; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sulfonamides; Temozolomide | 2010 |
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Line, Tumor; DNA; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Hydrazines; Mice; NADPH-Ferrihemoprotein Reductase; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Solubility; Structure-Activity Relationship; Sulfonamides; Xanthine Oxidase | 2011 |
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.
Topics: Antineoplastic Agents; Cell Hypoxia; Cell Line; Enzyme Inhibitors; Guanine; HL-60 Cells; Humans; Hydrazines; Hydrogen Peroxide; O(6)-Methylguanine-DNA Methyltransferase; Oxidation-Reduction; Oxygen; Purines; Sulfonamides; Superoxides | 2012 |
Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine.
Topics: Alkylation; Animals; Antineoplastic Agents; Cell Line, Tumor; DNA; DNA Modification Methylases; DNA Repair Enzymes; Glutathione; Glutathione Transferase; Guanine; Hydrazines; Mice; Prodrugs; Recombinant Proteins; Sulfonamides; Tumor Suppressor Proteins | 2014 |