Compounds > huperzine a

huperzine a and soman

huperzine a has been researched along with soman in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's8 (50.00)29.6817
2010's4 (25.00)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Ashani, Y; Doctor, BP; Grunwald, J; Raveh, L1
Aubriot, S; Baubichon, D; Burckhart, MF; Lallement, G; Masqueliez, C; Veyret, J1
Lallement, G; Masqueliez, C; Monmaur, P; Testylier, G; Tonduli, LS1
Baubichon, D; Carpentier, P; Dorandeu, F; Foquin, A; Lallement, G1
Baubichon, D; Clarençon, D; Demoncheaux, JP; Dorandeu, F; Foquin, A; Galonnier, M; Lallement, G1
Aisen, PS; Doctor, BP; Feaster, SR; Garcia, GE; Gordon, RK; Haigh, JR; Lenz, DE; Riel, MA1
Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA1
Eckert, S; Eyer, P; Worek, F1
Aisen, PS; Doctor, BP; Garcia, GE; Gordon, RK; Haigh, JR; Johnston, SR; Mattern, PJ; Peppernay, A1
Adler, M; Akkerman, M; Albuquerque, EX; Aracava, Y; Pereira, EF1
Doctor, BP; Jensen, N; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y1
Doctor, BP; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y1
Doctor, BP; Gunosewoyo, H; Kozikowski, AP; Nambiar, MP; Pieroni, M; Tipparaju, SK; Wang, Y1
Hamilton, LR; Myers, TM; Schachter, SC1
Kassa, J; Zdarova Karasova, J1
Chen, X; Cui, Y; Jin, Q; Li, L; Shi, J; Shi, T; Wang, C; Zhang, R1

Trials

1 trial(s) available for huperzine a and soman

ArticleYear
Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
    Chemico-biological interactions, 2008, Sep-25, Volume: 175, Issue:1-3

    Topics: Acetylcholinesterase; Administration, Oral; Aged; Alkaloids; Butyrylcholinesterase; Dose-Response Relationship, Drug; Erythrocytes; Humans; Sesquiterpenes; Soman

2008

Other Studies

15 other study(ies) available for huperzine a and soman

ArticleYear
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
    Life sciences, 1994, Volume: 54, Issue:14

    Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Binding Sites; Brain; Cholinesterase Inhibitors; Injections, Intraperitoneal; Kinetics; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Physostigmine; Poisoning; Sesquiterpenes; Soman; Time Factors

1994
Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality.
    Fundamental & clinical pharmacology, 1997, Volume: 11, Issue:5

    Topics: Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Hippocampus; Male; Neuroprotective Agents; Pyridostigmine Bromide; Receptors, N-Methyl-D-Aspartate; Seizures; Sesquiterpenes; Soman

1997
Effects of Huperzine used as pre-treatment against soman-induced seizures.
    Neurotoxicology, 2001, Volume: 22, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Kinetics; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Sesquiterpenes; Soman

2001
Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
    Drug and chemical toxicology, 2001, Volume: 24, Issue:2

    Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Male; Neuroprotective Agents; Physostigmine; Pyridostigmine Bromide; Scopolamine; Seizures; Sesquiterpenes; Soman; Time Factors

2001
Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
    Drug and chemical toxicology, 2002, Volume: 25, Issue:3

    Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Macaca fascicularis; Male; Pyridostigmine Bromide; Seizures; Sesquiterpenes; Soman

2002
Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
    Chemico-biological interactions, 2005, Dec-15, Volume: 157-158

    Topics: Administration, Oral; Alkaloids; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Humans; Neuroprotective Agents; Pyridostigmine Bromide; Sesquiterpenes; Soman

2005
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Aug-29, Volume: 103, Issue:35

    Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors

2006
Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
    Toxicology, 2007, Apr-20, Volume: 233, Issue:1-3

    Topics: Acetylcholinesterase; Alkaloids; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; In Vitro Techniques; Sesquiterpenes; Soman; Time Factors

2007
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:3

    Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Chemical Warfare Agents; Donepezil; Dose-Response Relationship, Drug; Galantamine; Guinea Pigs; Indans; Lethal Dose 50; Male; Phenylcarbamates; Piperidines; Poisoning; Rivastigmine; Sesquiterpenes; Soman; Time Factors; Toxicity Tests, Acute

2009
[+]-Huperzine A protects against soman toxicity in guinea pigs.
    Neurochemical research, 2011, Volume: 36, Issue:12

    Topics: Acetylcholinesterase; Alkaloids; Animals; Blood-Brain Barrier; Body Temperature; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Male; Neuroprotective Agents; Pyridostigmine Bromide; Seizures; Sesquiterpenes; Soman; Stereoisomerism

2011
A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Male; Neuroprotective Agents; Rats; Seizures; Sesquiterpenes; Soman; Stereoisomerism

2013
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Guinea Pigs; Neuroprotective Agents; Sesquiterpenes; Soman; Survival Analysis

2013
Time Course, Behavioral Safety, and Protective Efficacy of Centrally Active Reversible Acetylcholinesterase Inhibitors in Cynomolgus Macaques.
    Neurochemical research, 2017, Volume: 42, Issue:7

    Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Macaca fascicularis; Male; Pyridostigmine Bromide; Reaction Time; Seizures; Sesquiterpenes; Soman; Time Factors; Treatment Outcome

2017
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice.
    Toxicology mechanisms and methods, 2023, Volume: 33, Issue:7

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Memantine; Mice; Oximes; Poisons; Procyclidine; Pyridinium Compounds; Receptors, N-Methyl-D-Aspartate; Soman; Survival Rate

2023
Study of Huperzine A derivatives with extended protection against soman intoxication.
    Toxicology and applied pharmacology, 2023, 09-15, Volume: 475

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Mice; Molecular Docking Simulation; Nerve Agents; Soman

2023