huperzine a and soman
huperzine a has been researched along with soman in 16 studies
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ashani, Y; Doctor, BP; Grunwald, J; Raveh, L | 1 |
| Aubriot, S; Baubichon, D; Burckhart, MF; Lallement, G; Masqueliez, C; Veyret, J | 1 |
| Lallement, G; Masqueliez, C; Monmaur, P; Testylier, G; Tonduli, LS | 1 |
| Baubichon, D; Carpentier, P; Dorandeu, F; Foquin, A; Lallement, G | 1 |
| Baubichon, D; Clarençon, D; Demoncheaux, JP; Dorandeu, F; Foquin, A; Galonnier, M; Lallement, G | 1 |
| Aisen, PS; Doctor, BP; Feaster, SR; Garcia, GE; Gordon, RK; Haigh, JR; Lenz, DE; Riel, MA | 1 |
| Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA | 1 |
| Eckert, S; Eyer, P; Worek, F | 1 |
| Aisen, PS; Doctor, BP; Garcia, GE; Gordon, RK; Haigh, JR; Johnston, SR; Mattern, PJ; Peppernay, A | 1 |
| Adler, M; Akkerman, M; Albuquerque, EX; Aracava, Y; Pereira, EF | 1 |
| Doctor, BP; Jensen, N; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y | 1 |
| Doctor, BP; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y | 1 |
| Doctor, BP; Gunosewoyo, H; Kozikowski, AP; Nambiar, MP; Pieroni, M; Tipparaju, SK; Wang, Y | 1 |
| Hamilton, LR; Myers, TM; Schachter, SC | 1 |
| Kassa, J; Zdarova Karasova, J | 1 |
| Chen, X; Cui, Y; Jin, Q; Li, L; Shi, J; Shi, T; Wang, C; Zhang, R | 1 |
Trials
1 trial(s) available for huperzine a and soman
| Article | Year |
|---|---|
Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Topics: Acetylcholinesterase; Administration, Oral; Aged; Alkaloids; Butyrylcholinesterase; Dose-Response Relationship, Drug; Erythrocytes; Humans; Sesquiterpenes; Soman | 2008 |
Other Studies
15 other study(ies) available for huperzine a and soman
| Article | Year |
|---|---|
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Binding Sites; Brain; Cholinesterase Inhibitors; Injections, Intraperitoneal; Kinetics; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Physostigmine; Poisoning; Sesquiterpenes; Soman; Time Factors | 1994 |
Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality.
Topics: Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Hippocampus; Male; Neuroprotective Agents; Pyridostigmine Bromide; Receptors, N-Methyl-D-Aspartate; Seizures; Sesquiterpenes; Soman | 1997 |
Effects of Huperzine used as pre-treatment against soman-induced seizures.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Kinetics; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Sesquiterpenes; Soman | 2001 |
Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Male; Neuroprotective Agents; Physostigmine; Pyridostigmine Bromide; Scopolamine; Seizures; Sesquiterpenes; Soman; Time Factors | 2001 |
Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Macaca fascicularis; Male; Pyridostigmine Bromide; Seizures; Sesquiterpenes; Soman | 2002 |
Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
Topics: Administration, Oral; Alkaloids; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Humans; Neuroprotective Agents; Pyridostigmine Bromide; Sesquiterpenes; Soman | 2005 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors | 2006 |
Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
Topics: Acetylcholinesterase; Alkaloids; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; In Vitro Techniques; Sesquiterpenes; Soman; Time Factors | 2007 |
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Chemical Warfare Agents; Donepezil; Dose-Response Relationship, Drug; Galantamine; Guinea Pigs; Indans; Lethal Dose 50; Male; Phenylcarbamates; Piperidines; Poisoning; Rivastigmine; Sesquiterpenes; Soman; Time Factors; Toxicity Tests, Acute | 2009 |
[+]-Huperzine A protects against soman toxicity in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Blood-Brain Barrier; Body Temperature; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Male; Neuroprotective Agents; Pyridostigmine Bromide; Seizures; Sesquiterpenes; Soman; Stereoisomerism | 2011 |
A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Male; Neuroprotective Agents; Rats; Seizures; Sesquiterpenes; Soman; Stereoisomerism | 2013 |
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Guinea Pigs; Neuroprotective Agents; Sesquiterpenes; Soman; Survival Analysis | 2013 |
Time Course, Behavioral Safety, and Protective Efficacy of Centrally Active Reversible Acetylcholinesterase Inhibitors in Cynomolgus Macaques.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Macaca fascicularis; Male; Pyridostigmine Bromide; Reaction Time; Seizures; Sesquiterpenes; Soman; Time Factors; Treatment Outcome | 2017 |
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Memantine; Mice; Oximes; Poisons; Procyclidine; Pyridinium Compounds; Receptors, N-Methyl-D-Aspartate; Soman; Survival Rate | 2023 |
Study of Huperzine A derivatives with extended protection against soman intoxication.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Mice; Molecular Docking Simulation; Nerve Agents; Soman | 2023 |