honokiol and lignans
honokiol has been researched along with lignans in 708 studies
Research
Studies (708)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (1.55) | 18.7374 |
| 1990's | 29 (4.10) | 18.2507 |
| 2000's | 129 (18.22) | 29.6817 |
| 2010's | 408 (57.63) | 24.3611 |
| 2020's | 131 (18.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sheng, J; Yu, Q | 1 |
| Hu, M; Tang, X; Zhao, Z | 1 |
| Feng, L; Han, G; Yang, J | 1 |
| Jia, M; Zhou, G | 1 |
| Zhang, GD | 1 |
| Cui, JF; Song, WZ; Zhang, GD | 1 |
| Hou, YM; Li, Z; Lin, X; Zhang, M | 1 |
| Chen, CC; Kao, LS; Liu, PS | 1 |
| Li, AJ | 1 |
| Chen, CC; Chen, YP; Hsu, HY; Huang, TF; Ko, FN; Lee, LG; Teng, CM | 1 |
| Fujimura, H; Matsuda, H; Miki, S; Yamahara, J | 1 |
| Chen, JM; Ji, CY; Song, WZ | 1 |
| Goto, Y; Hagino, K; Watanabe, H; Watanabe, K; Yamaguchi, M; Yamamoto, N | 1 |
| Hagino, K; Watanabe, H; Watanabe, K | 1 |
| Cheng, DC; Liu, JW | 1 |
| Chen, CF; Lee, TF; Tsai, TH; Wang, LC; Westly, J | 1 |
| Chen, CF; Chou, CJ; Tsai, TH | 1 |
| Homma, M; Itoh, H; Niitsuma, T; Oka, K | 1 |
| Chen, CF; Cheng, FC; Chou, CJ; Tsai, TH | 1 |
| Chen, CC; Chen, CF; Hong, CY; Lo, YC; Teng, CM | 1 |
| Kawai, T; Kinoshita, K; Koyama, K; Takahashi, K | 1 |
| Fujii, I; Kuroyanagi, M; Miwa, M; Sugatani, J; Suzuki, Y; Ueno, A; Umehara, K; Yamazaki, R | 1 |
| Asaka, N; Hayashi, Y; Hirose, Y; Momma, N; Ohsawa, K; Tanaka, I; Ueda, J; Yasuda, T | 1 |
| Momma, N; Ohsawa, K; Ueda, J | 1 |
| Chang, Z; Zhou, F | 1 |
| Hamasaki, Y; Ichimaru, T; Kobayashi, I; Matsuo, M; Miyanji, S; Miyazaki, S; Muro, E; Sato, R; Tasaki, H; Yamamoto, S; Zaitu, M | 1 |
| Hong, CY; Huang, SS; Tsai, SK | 1 |
| Fukuda, A; Haraguchi, H; Ishikawa, H; Shirataki, N | 1 |
| Chiu, JH; Ho, CT; Hong, CY; Lui, WY; Wei, YH | 1 |
| Kuribara, H; Maruyama, Y; Morita, M; Weintraub, ST; Yuzurihara, M | 1 |
| Bae, K; Chang, B; Chung, C; Ku, Y; Lee, Y | 1 |
| Kuribara, H; Maruyama, Y; Stavinoha, WB | 2 |
| Achiwa, Y; Hasegawa, M; Hibasami, H; Imai, K; Ishii, Y; Katsuzaki, H; Komiya, T; Nakanishi, K; Yoshioka, K | 1 |
| Hong, CY; Huang, CH; Huang, SS; Hung, LM; Tsai, SK | 1 |
| Hattori, N; Kishi, E; Kuribara, H; Maruyama, Y; Yuzurihara, M | 1 |
| Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR | 1 |
| Bae, KH; Bang, KH; Kim, YK; Lee, JP; Min, BS; Na, MK; Rhee, YH | 1 |
| Kashimoto, T; Tachikawa, E; Takahashi, M | 1 |
| Lee, HJ; Ryu, JH; Son, HJ; Yun-Choi, HS | 1 |
| Chao, PD; Chen, SY; Hou, YC | 1 |
| Kimura, M; Kishi, E; Kuribara, H; Maruyama, Y; Weintraub, ST | 1 |
| Hattori, N; Kishi, E; Kuribara, H; Maruyama, Y; Okada, M | 1 |
| Chen, CP; Ho, KY; Huang, JS; Lin, CC; Tsai, CC | 1 |
| Ai, J; Nielsen, M; Wang, X | 1 |
| Hu, X; Kuang, L; Li, F; Pan, Z; Wu, Z; Zhang, G | 1 |
| Ikeda, K; Nagase, H; Sakai, Y | 1 |
| Hattori, N; Ikarashi, Y; Maruyama, Y; Nakai, Y; Sakakibara, I; Yuzurihara, M | 1 |
| Fukuyama, Y; Minoshima, Y; Mitsumoto, Y; Nakade, K; Yokoyama, R; Zhai, H | 1 |
| Hsieh, MT; Hsu, SL; Tsai, TH; Yang, SE | 1 |
| Liu, Y; Lu, J; Pei, X; Tang, C | 1 |
| Si, JP; Tong, ZK; Zeng, YR | 1 |
| Du, K; Wang, JX; Yuan, C; Zhu, LQ | 1 |
| Bae, K; Kim, YH; Lee, BH; Na, M; Park, EJ; Sohn, DH; Zhao, YZ | 1 |
| Pan, X; Si, J; Tong, Z; Zeng, Y | 1 |
| Pan, X; Si, J; Tong, Z; Zeng, Y; Zhu, Y | 1 |
| Si, J | 1 |
| Jiang, X; Liu, R; Si, J; Tong, Z; Zeng, Y | 1 |
| Chih, CL; Huang, SS; Lin, SM; Liou, KT; Tsai, SK | 1 |
| Arbiser, JL; Bai, X; Battle, T; Campbell, PM; Cerimele, F; Der, CJ; Dubiel, W; Frank, DA; Govindarajan, B; Murad, E; Soff, G; Ushio-Fukai, M; Waqas, M; Ye, K | 1 |
| Chan, MH; Chen, HH; Ko, CH; Lin, YR | 4 |
| Fukuyama, Y; Mitsumoto, Y; Nakade, K; Zhai, H | 1 |
| Chen, CF; Liou, KT; Shen, YC; Tsai, SK; Tsao, CM | 2 |
| Chan, MH; Chen, HH; Ko, CH; Lin, YR; Lu, YC | 1 |
| Chen, SZ; Jia, H; Wang, H; Wu, YH | 1 |
| Esumi, T; Fukuyama, Y; Makado, G; Mitsumoto, Y; Shimizu, Y; Zhai, H | 1 |
| Geng, Y; Li, F; Wang, X; Wang, Y; Zheng, C | 1 |
| Chen, F; Chen, Z; Hu, X; Wang, T; Wu, YF; Xu, XL; Zheng, S | 1 |
| Jung, E; Jung, K; Kim, J; Kim, K; Lee, J; Park, B; Park, D; Park, E; Park, J; Park, Y | 1 |
| Fong, WF; Poon, KH; Tse, AK; Wang, C | 1 |
| Jifang, S; Jun, L; Miaoquan, L; Xihong, X; Yingyan, L | 1 |
| Chen, F; Gu, Y; Hu, X; Wang, T; Wu, YF; Xu, XL; Zheng, S | 1 |
| Kong, ZL; Liu, YC; Tzeng, SC | 1 |
| Kim, YH; Lee, BH; Park, EJ; Sohn, DH; Zhao, YZ | 1 |
| Hakamata, H; Jin, D; Kojima, S; Kotani, A; Kusu, F | 1 |
| Arbiser, J; Battle, TE; Frank, DA | 1 |
| Hong, S; Jung, E; Jung, K; Kim, J; Lee, J; Lee, S; Park, D; Park, E; Park, J; Park, S | 1 |
| Anderson, KC; Arbiser, J; Chauhan, D; Hamasaki, M; Hideshima, H; Hideshima, T; Ishitsuka, K; Kumar, S; Le Gouill, S; Podar, K; Raje, N; Richardson, P; Roccaro, AM; Shiraishi, N; Tamura, K; Yasui, H | 1 |
| Akagi, M; Fukuyama, Y; Mitsumoto, Y; Nakade, K; Oda, M; Sakurai, J; Zhai, H | 1 |
| Cao, H; Li, Y; Sun, QS; Tian, F; Wang, MW; Wang, XQ; Zhang, WW | 1 |
| Chen, SZ; Hu, H; Wang, YY; Zhang, XX | 1 |
| Guo, BL; Huang, WH; Si, JP | 1 |
| Fong, WF; Shen, XL; Tse, AK; Wan, CK; Yang, M | 1 |
| Cao, AH; King, RG; Vo, LT | 1 |
| Hanawa, T; Ito, G; Koyama, H; Oikawa, T | 1 |
| Hu, X; Lu, Q; Xu, D | 1 |
| Chen, X; Fan, L; Hu, Z; Liu, L; Wu, X | 1 |
| Lu, Y; Pan, Y; Sun, C | 1 |
| Chou, FP; Lin, TM; Ou, HC; Sheu, WH; Yang, CH | 1 |
| Lin, LC; Tsai, TH; Wu, YT | 1 |
| Chen, G; Xu, X; Yang, P; Zhang, L; Zhu, Y | 1 |
| Amblard, F; Arbiser, JL; Delinsky, D; Schinazi, RF | 1 |
| Kim, SY; Park, EJ; Sohn, DH; Zhao, YZ | 1 |
| Chiang, CK; Hung, KY; Liu, SH; Sheu, ML; Wu, KD | 1 |
| Chen, G; Xu, X; Yang, P; Yao, X | 1 |
| Kim, CH; Lee, B; Moon, SK | 1 |
| Aggarwal, BB; Ahn, KS; Arbiser, JL; Sethi, G; Shishodia, S; Sung, B | 1 |
| Li, K; Su, W; Yuan, J | 1 |
| Chen, S; Wang, Y; Zhang, X | 1 |
| Chen, L; Fan, L; Fisher, D; Garrard, I; Ignatova, S; Sutherland, IA; Tang, J; Yang, G; Zhang, Q | 1 |
| Chang, HT; Chang, PL; Chen, CL; Kuo, CH; Lee, SS; Peng, FC | 1 |
| Arbiser, JL; Chung, LW; Fujisawa, M; Gotoh, A; Johnstone, PA; Shigemura, K; Sun, SY; Weksler, B; Zayzafoon, M; Zhau, HE | 1 |
| Han, J; Wang, WZ; Wu, LZ; Zhang, P; Zheng, P | 1 |
| Ke, XH; Lin, SF; Wei, G | 1 |
| Bae, K; Cui, HS; Huang, LS; Kwon, BM; Shin, J; Sok, DE; Youn, UJ | 1 |
| Amblard, F; Arbiser, JL; Karlan, BY; Koeffler, HP; Nguyen, A; O'Kelly, J; Wakimoto, N; Wolf, I | 1 |
| Gu, Y; Han, W; Hu, X; Jin, J; Li, L; Lu, Q; Luo, J; Qiu, S | 1 |
| Amblard, F; Arbiser, JL; Detorio, M; Govindarajan, B; Lefkove, B; Rapp, KL; Schinazi, RF | 1 |
| Feng, J; Li, JY; Zhou, XD | 1 |
| Arbiser, JL; Bishop, GA; Munroe, ME | 1 |
| Chen, CM; Lin-Shiau, SY; Liu, SH | 1 |
| Chen, J; Li, N; Roberts, A; Song, Y; Wang, W; Wong, AW; Zhang, W | 1 |
| Arbiser, JL; Bhandarkar, S; Cance, WG; Funa, NS; Kurenova, EV; Reddy, K; Welsh, M; Yang, L | 1 |
| Hahm, ER; Singh, SV | 1 |
| Lan, KH; Liu, SH; Sheu, ML | 1 |
| Bae, EA; Bae, KH; Han, SJ; Kim, DH; Trinh, HT; Yang, JH; Youn, UJ | 1 |
| Chen, H; Chen, L; Fu, A; Fu, J; Luo, H; Luo, Y; Peng, A; Peng, C; Shi, J; Wei, Y; Xie, D; Xu, Y; Yang, S; Ye, H | 1 |
| Kong, LD; Li, JM; Li, YC; Pan, Y; Wang, CP; Wang, X; Xu, Q; Yi, LT | 1 |
| Chen, LJ; Huang, CH; Liang, SF; Ling, B; Liu, XY; Tang, MH; Wei, YQ; Xu, YH; Zhao, X; Zhao, XY | 1 |
| Cho, JY; Kim, BH | 1 |
| Dai, M; Gong, CY; Gou, ML; Li, XY; Qian, ZY; Wang, K; Wang, XH; Wei, YQ; Xie, Y; Zhao, X | 1 |
| Arlotti, JA; Hahm, ER; Marynowski, SW; Singh, SV | 1 |
| Chen, LJ; Fu, AF; Lin, HG; Luo, H; Qi, XR; Wei, YQ; Yang, F; Yang, HS; Zhao, X; Zhong, Q | 1 |
| Dong, H; Liu, Y; Song, R; Tian, Y; Xu, F; Zhang, Z | 1 |
| Baile, CA; Della-Fera, MA; Rayalam, S; Yang, JY | 1 |
| Chiang, CK; Ho, FM; Liu, SH; Sheu, ML; Tsai, KS; Weng, TI; Wu, HY | 1 |
| Chen, L; Huang, C; Li, Z; Liu, Y; Pan, X; Wei, Y; Yin, R; Zhao, X | 1 |
| Chen, L; Dai, M; Deng, H; Gong, C; Gou, M; Li, X; Qian, Z; Wang, X; Wei, Y; Xie, Y; Zhao, X | 1 |
| Chan, SS; Che, CT; Fong, HH; Lao, L; Zhao, M | 1 |
| Chen, J; Deng, J; Geng, L; Jiang, G; Qian, Y; Wang, X; Xie, H; Yan, S; Zheng, S; Zhou, L | 1 |
| Chen, L; Chen, X; Hou, W; Hu, J; Jiang, Q; Tang, M; Wang, X; Wei, Y; Wen, J; Yang, G; Yuan, Y; Zhong, Z; Zhou, H | 1 |
| Elstner, E; Emde, A; Eucker, J; Kühnl, A; Liu, H; Planas-Silva, MD; Possinger, K; Rosche, M; Schulz, CO; Zang, C | 1 |
| Arbiser, JL; Bar-Sagi, D; Brown, HA; Fan, J; Foster, DA; Garcia, A; Shraibman, N; Toschi, A; Zhao, C; Zheng, Y | 1 |
| Lan, XQ; Liao, CL; Lin, XM; Shi, L; Yang, HB; Zhan, YH | 1 |
| Huang, X; Jiang, L; Qin, E; Ren, P; Su, WJ | 1 |
| Arbiser, JL; Dikalov, S; Losik, T | 1 |
| Acker, TM; Arbiser, JL; Chen, S; Khuri, FR; Lefkove, B; Raja, SM; Sun, SY; Yue, P | 1 |
| Chen, LJ; Fan, LY; Guo, WH; Hou, WL; Jiang, QQ; Wei, YQ; Yang, GL | 1 |
| Sy, HN; Wang, SJ; Wang, WF; Wu, SL | 1 |
| Chen, LJ; Fu, AF; Hou, WL; Yang, GL; Yin, XH; Zhong, ZH | 1 |
| Chen, S; Gu, X; Huang, X; Qin, F; Ren, P; Zhang, H | 1 |
| Chen, L; Fu, S; Gong, C; Gou, M; Men, K; Qian, Z; Qiu, L; Shi, S; Wei, X; Zeng, S; Zheng, X | 1 |
| Guo, BL; Jiang, YF; Lv, D; Si, JP; Tong, ZK; Zhu, YQ | 1 |
| Chen, LJ; Chen, PL; Chen, X; Hou, WL; Hu, J; Liu, L; Tang, MH; Wang, XH; Wei, YQ; Yang, G; Zhang, F; Zhao, X | 1 |
| Bae, K; Chung, HJ; Hong, JY; Hung, TM; Kang, SS; Kang, YJ; Kim, YS; Lee, SK; Min, HY; Park, EJ; Youn, UJ | 1 |
| Ajani, JA; Chen, G; Demizu, Y; Guha, S; Huang, P; Hung, MC; Izzo, J; Wang, F; Wu, X | 1 |
| Arbiser, JL; Fried, LE | 1 |
| Dong, PW; Fu, SZ; Gong, CY; Guo, G; Qian, ZY; Shi, S; Wei, YQ; Yang, JL; Zheng, XL | 1 |
| Chen, LJ; Chen, P; Chen, XC; Fu, AF; Li, J; Lu, Y; Shao, XM; Tang, MH; Wang, YS; Wei, YQ; Wen, J; Xie, XJ; Yang, GL; Zhao, X | 1 |
| Bae, BK; Choi, GJ; Choi, JE; Choi, NH; Choi, YH; Jang, KS; Kang, MS; Kim, JC; Min, BS; Park, MS | 1 |
| Kapoor, S | 1 |
| Chen, CC; Chiang, J; Hou, YC; Juan, CW; Liao, JF; Liou, KT; Shen, YC; Wang, YH; Yu, MC | 1 |
| Chung, YS; Kim, YC; Lee, BH; Shin, YK; Yin, HQ | 1 |
| Chen, L; Gou, M; Guo, G; Luo, F; Men, K; Peng, X; Qian, Z; Wei, Y; Zeng, S; Zhao, X; Zheng, L; Zheng, X | 1 |
| Chen, L; Guo, Q; Kong, X; Li, X; Qian, Z; Shi, S; Wei, Y; Zhao, X; Zheng, X | 1 |
| Chen, L; Gong, C; Gou, M; Gu, Y; Guo, G; Luo, F; Qian, Z; Wang, X; Wei, Y; Zhang, J; Zhao, X | 1 |
| Chen, L; Dong, P; Fu, S; Gong, C; Qian, Z; Shi, S; Wang, X; Wang, Y; Wei, Y; Zhao, X | 1 |
| Chen, L; Deng, H; Ding, Z; Gou, L; Lai, S; Li, J; Liu, H; Mao, Y; Nie, C; Wang, Y; Wei, Y; Yan, F; Yuan, Z; Zhao, X; Zhao, Y | 1 |
| Chen, L; Han, J; Hu, J; Huang, W; Li, R; Luo, Y; Peng, C; Peng, M; Shi, J; Wei, Y; Xie, D; Xu, G; Xu, Y; Yang, S | 1 |
| He, S; Lei, ZJ; Zhang, SY; Zhang, ZY | 1 |
| Chávez-Avila, VM; Chivez, M; Cruz-Sosa, F; Domínguez, F; Garduñ-Ramírez, ML; Mata, M | 1 |
| Kong, LD; Pan, Y; Qiang, LQ; Wang, CP; Wang, FM; Yi, LT; Zhang, X | 1 |
| Cho, JY; Lee, SY | 1 |
| Chan, MH; Chen, HH; Ko, CH; Lin, YC; Lin, YR | 1 |
| Chen, YJ; Fong, YC; Hsu, SF; Li, TM; Liu, JF; Liu, SH; Su, YC; Tang, CH; Wu, CL | 1 |
| Chen, L; Fang, F; Gong, C; Gou, M; Gu, Y; Guo, G; Liu, J; Luo, F; Qian, Z; Wei, Y; You, C; Zhang, X; Zhang, Y; Zhao, X; Zhou, L | 1 |
| Chen, L; Dai, M; Gong, C; Gou, M; Guo, G; Li, X; Qian, Z; Wang, X; Wei, X; Wei, Y; Zheng, X | 1 |
| Chen, L; Fu, S; Gou, M; Kan, B; Luo, F; Men, K; Qian, Z; Wei, Y; Zhang, J; Zhao, X; Zhao, Y; Zheng, X | 1 |
| He, S; Lei, Z; Xu, F; Zhang, S; Zhang, Z | 1 |
| Chen, L; Fu, A; Liang, S; Tang, M; Wei, Y; Zhang, Q; Zhou, J | 1 |
| Chen, L; Gou, M; Luo, F; Men, K; Qian, Z; Wang, X; Wei, Y; Zhang, J; Zhao, X; Zheng, X | 1 |
| Luo, JD; Luo, MS; Wang, RJ; Zhang, GP; Zhang, GS; Zhang, HN | 1 |
| Ahn, JY; Cha, BY; Hasegawa, S; Nagai, K; Takami, M; Teruya, T; Woo, JT; Yagasaki, K; Yonezawa, T | 1 |
| Hwang, W; Kim, YS; Lee, J; Lee, JY; Park, D; Park, J | 1 |
| Chao, LK; Chiu, HW; Chuang, CC; Ho, CL; Hua, KF; Hung, LB; Liao, PC; Wang, EI | 1 |
| Chávez, M; Chávez-Avila, VM; Cruz-Sosa, F; Domínguez, F; Garduño-Ramírez, ML; Mata, M | 1 |
| Wang, Y; Yang, Z; Zhao, X | 1 |
| Chen, L; He, S; Li, S; Luo, Y; Peng, A; Peng, M; Shi, J; Wei, Y; Xu, G; Ye, H; Zhong, S | 1 |
| Arbiser, JL; Bhola, NE; Cai, Q; Grandis, JR; Joyce, SC; Leeman-Neill, RJ; Neill, DB; Thomas, SM | 1 |
| Chilampalli, S; Dwivedi, C; Fahmy, H; Hildreth, MB; Kaushik, RS; Zeman, D; Zhang, X | 1 |
| Gong, C; Guo, G; Luo, F; Mao, Y; Qian, Z; Wang, X; Wang, Y; Wei, X | 1 |
| Wang, X; Zhang, L | 1 |
| Cheng, LF; Wu, F; Wu, JP; Xie, JJ; Yao, HP; Zhang, W; Zhao, Y | 1 |
| Cha, BY; Horike, H; Hosono, T; Iida, K; Jung, CG; Michikawa, M; Uhm, KO; Woo, JT; Yamaguchi, T; Yamauchi, R | 1 |
| Chueh, JT; Lee, TC; Lin, KL; Liu, SH; Pan, HC; Shen, CC; Sheu, ML; Tsai, JJ; Wang, CC; Yi, YC | 1 |
| Kunert, O; Schuehly, W; Teppner, H; Voith, W | 1 |
| Deng, X; Ding, Y; Guo, N; Jin, J; Li, L; Liang, J; Tang, X; Yu, L; Zhang, J | 1 |
| Inoue, M; Kotani, H; Makishima, M; Mizukami, H; Tanabe, H | 1 |
| Chang-Mu, C; Jen-Kun, L; Shing-Hwa, L; Shoei-Yn, LS | 1 |
| Chun, KS; Chung, WY; Kim, KR; Park, KK | 1 |
| Chen, L; He, S; Li, S; Peng, A; Shi, J; Ye, H; Zhong, S | 1 |
| Hu, Y; Li, H; Wang, X | 1 |
| Katiyar, SK; Sharma, SD; Vaid, M | 1 |
| Chen, DC; Chen, WC; Chen, YH; Cheng, YW; Chou, MC; Huang, PH; Liu, PL; Man, KM; Shen, JL | 1 |
| Baum, L; Chow, AH; Ho, YP; Hoi, CP | 1 |
| Bishop, GA; Businga, TR; Kline, JN; Munroe, ME | 1 |
| Tang, X; Yang, Y; Yao, H; Yao, K; Zhang, L | 1 |
| Cai, LL; Chen, L; Qiu, N; Song, H; Wang, G; Wu, W; Xie, D; Yin, H; Zhang, Y | 1 |
| Chen, LJ; Gou, ML; Guo, QF; Huang, MJ; Kan, B; Liang, SF; Luo, F; Men, K; Qian, ZY; Shi, S; Wang, XH; Wei, YQ; Zhao, X | 1 |
| Chen, L; Gong, C; Gou, M; Luo, F; Qian, Z; Wang, B; Wang, X; Wei, X; Yang, L; Zhao, Y; Zheng, X | 1 |
| Li, H; Li, L; Shao, X; Wu, F; Zhang, W; Zheng, F; Zhou, J | 1 |
| Katiyar, SK; Singh, T | 2 |
| Chen, MW; Chiang, CK; Hung, KY; Lin, YW; Liu, SH; Sheu, ML; Wu, CT; Wu, KD; Yang, CC | 1 |
| Kuo, CW; Liu, SH; Weng, TI; Wu, HY | 1 |
| Chen, L; Fu, A; Hu, J; Luo, Y; Ma, Y; Peng, M; Wang, T; Wei, Y; Zhu, W | 1 |
| Cha, BY; Choi, SS; Iida, K; Lee, YS; Nagai, K; Sato, M; Teruya, T; Woo, JT; Yonezawa, T | 1 |
| Cai, L; Chen, L; Deng, C; Deng, L; Duan, X; Wang, X; Wei, Y; Zhang, X; Zhao, X; Zheng, H | 1 |
| Cai, LL; Chen, LJ; Deng, CY; Deng, LY; Wang, XH; Wei, YQ; Wen, JL; Zhang, XY; Zhao, X; Zheng, H | 1 |
| Böhmdorfer, M; Hering, S; Hüfner, A; Jäger, W; Maier-Salamon, A; Reznicek, G; Schühly, W; Taferner, B; Thalhammer, T | 1 |
| Chen, XR; Dan, HX; Ji, N; Li, XY; Liao, G; Lu, R; Zhou, M | 1 |
| Mannal, PW; McDonald, D; McFadden, DW; Schneider, J; Tangada, A | 1 |
| Chen, MY; Hsu, FC; Lan, KH; Lan, KL; Liu, RS; Sheu, ML; Shih, YS; Wang, HM; Yen, SH | 1 |
| Alonso-Castro, AJ; Domínguez, F; García-Carrancá, A; Salazar-Olivo, LA; Zapata-Bustos, R | 1 |
| Fang, M; Feng, T; Jin, C; Li, J; Shao, X; Wu, L; Wu, N; Yao, H | 1 |
| Chen, L; Deng, C; Deng, L; Duan, X; Peng, C; Wang, N; Wang, X; Wei, Y; Wen, J; Yang, G; Zhang, X; Zhao, X; Zheng, H | 1 |
| Fan, CH; Ku, TH; Lee, YJ; Tien, LT; Wang, SJ | 1 |
| Choi, EM | 2 |
| Chang, HZ; Chao, LK; Chen, ST; Cheng, WC; Chiang, CS; Fang, SH; Ho, CL; Hsu, IC; Hua, KF; Kuo, YH; Li, CY; Liao, PC; Tsai, ML; Wang, SC | 1 |
| Baburin, I; Ecker, GF; Hering, S; Huefner, A; Schuehly, W; Taferner, B; Wiesner, K | 1 |
| Liu, ZQ; Zhao, C | 1 |
| Arora, S; Bhardwaj, A; McClellan, S; Singh, AP; Singh, S; Srivastava, SK; Wang, B | 1 |
| Abbasi, T; Ahn, KS; Kapoor, S; Kumar, AP; Li, F; Rajendran, P; Sethi, G; Shanmugam, MK; Vali, S | 1 |
| Cha, BY; Cho, HJ; Kim, IK; Seok, YM; Woo, JT | 1 |
| Anant, S; Dhar, A; He, Z; Postier, RG; Ramalingam, S; Subramaniam, D; Umar, S; Zhang, Y | 1 |
| Chen, J; Lai, X; Wu, A; Zeng, B | 1 |
| Chen, J; Chen, L; Jie, S; Li, S; Liang, X; Luo, Y; Ma, L; Peng, A; Peng, M; Wang, T; Wang, X; Wei, Y; Zhu, W | 1 |
| Guo, D; He, R; Li, Q; Li, R; Lin, X; Qiao, X; Xiang, C; Ye, M | 1 |
| Arbiser, JL; Weitzmann, MN; Yamaguchi, M | 1 |
| Chandrasekher, G; Chilampalli, C; Dwivedi, C; Fahmy, H; Guillermo, R; Kaushik, RS; Young, A | 1 |
| Alonso-Castro, AJ; Domínguez, F; Garcia-Carranca, A; Gonzalez-Espindola, LA; Gonzalez-Martinez, Mdel R; Jacobo-Salcedo, Mdel R | 1 |
| Arbiser, J; Arlt, MJ; Banke, IJ; Born, W; Fuchs, B; Langsam, B; Muff, R; Steinmann, P; Walters, DK; Ziegler, U | 1 |
| Fu, S; Ren, Y; Sun, C; Tao, X | 1 |
| Baek, BJ; Koh, YW; Kwon, BM; Lee, BD; Lee, JD; Lee, JY; Lee, WS; Lee, YJ | 1 |
| Hung, LR; Lan, KH; Lan, KL; Lee, SD; Lee, WP; Lin, HC; Tseng, SH; Wang, YW; Yen, SH | 1 |
| Chen, W; Lin, GW; Zhang, Q | 1 |
| Chan, MH; Chen, C; Tripathi, S | 1 |
| Chakravarty, S; Chandrasekhar, S; Gajendra Reddy, R; Grée, R; Praveen Kumar, V; Vo, DD | 1 |
| Amagaya, S; Inoue, M; Kotani, H; Mizukami, H; Tanabe, H | 1 |
| Chen, BL; Liu, SH; Weng, TI; Wu, HY | 1 |
| Chen, JT; Chen, RM; Hong, CY; Lai, GM; Lin, JW; Lin, YL; Wang, KT; Yao, CJ | 1 |
| Chan, MH; Chen, HH; Fujita-Hamabe, W; Harada, S; Kishimoto, M; Kobayashi, M; Nakamoto, K; Tokuyama, S | 1 |
| Chen, SC; Huang, HY; Huang, KD; Huang, KH; Lin, WC; Liu, SH; Weng, TI | 1 |
| Gao, Y; Han, P; Liu, H; Luan, F; Yan, X | 1 |
| Chen, H; Deng, SP; Guan, XL; Li, J; Niu, XT; Su, XJ; Tang, MT; Wu, Q; Yang, RY | 1 |
| Anant, S; He, Z; Mammen, JM; Ponnurangam, S; Ramalingam, S; Subramaniam, D; Umar, S; Zhang, Y | 1 |
| Arbiser, JL; Bonner, MY; Nagalingam, A; Saxena, NK; Sharma, D | 1 |
| Alexeev, M; Fisher, JL; Grosenbaugh, DK; Mott, DD | 1 |
| Arbiser, JL; Ishikawa, C; Mori, N | 1 |
| Cheng, Z | 1 |
| Amin, S; Lin, JM; Prakasha Gowda, AS; Sharma, AK | 1 |
| Chen, CR; Fan, K; Hou, YP; Huang, ZL; Qu, WM; Sun, Y; Urade, Y; Yue, XF | 1 |
| Du, J; Huang, C; Huang, S; Huang, W; Li, Y | 1 |
| Mitra, AK; Mukherji, M; Pal, D; Ponnaluri, VK; Vadlapatla, RK; Vavilala, DT | 1 |
| Anavi-Goffer, S; Gertsch, J | 1 |
| Arbiser, JL; Cheng, E; Huo, X; Souza, RF; Spechler, SJ; Wang, DH; Yu, C; Zhang, HY; Zhang, Q; Zhang, X | 1 |
| Hu, W; Luo, Q; Qu, W; Xiong, X; Zhang, P; Zhang, S | 1 |
| Gong, YP; Guo, Y; Lin, J; Shan, QQ; Yang, X; Zhou, RQ | 1 |
| Arora, S; Contreras, CM; Panyam, J; Piazza, GA; Singh, AP; Singh, S | 1 |
| Bae, K; Bae, SY; Kim, GD; Lee, SK; Park, HJ | 1 |
| Chilampalli, C; Dwivedi, C; Fahmy, H; Guillermo, RF; Zeman, D; Zhang, X | 1 |
| Chang, KC; Jeong, JJ; Kim, HJ; Lee, JH | 1 |
| Chen, GY; Gong, HL; Huang, X; Tang, WF; Wang, J | 1 |
| Chen, YC; Cheng, HC; Lan, KH; Lee, WJ; Liao, KK; Liu, SH; Pan, HC; Peng, YC; Shen, CC; Sheu, ML; Wang, KB; Wu, SM | 1 |
| Bernard, P; Do, QT; Scior, T | 1 |
| Han, HK; Van Anh, LT | 1 |
| Deng, YC; Tian, W; Xu, D | 1 |
| Bian, X; Chen, S; Hu, Z; Liu, X; Wang, K; Wang, Y; Zhang, X; Zhu, Y | 1 |
| Katiyar, SK; Prasad, R; Singh, T | 2 |
| Anant, S; Kaushik, G; Mammen, JM; Protti, P; Ramalingam, S; Rammamoorthy, P; Rangarajan, P; Subramaniam, D | 1 |
| Deng, Y; He, H; Li, L; Sun, J; Tian, W; Xu, D | 1 |
| Li, MM; Shi, L; Yang, HB; Yu, JJ | 1 |
| Chen, S; Liu, X; Wang, Y; Zhang, P; Zhou, D; Zhu, Y | 1 |
| Wang, Y; Yang, Z; Zhao, X; Zhu, X | 1 |
| Chan, MH; Chuang, DY; Cui, J; Folk, WR; Fritsche, KL; Gu, Z; He, Y; Jiang, JH; Lee, JC; Lubahn, DB; Sheng, W; Simonyi, A; Sun, AY; Sun, GY; Zong, Y | 1 |
| Al-Suwayeh, SA; Fang, JY; Huang, YL; Hung, YY; Hwang, TL; Lin, CF | 1 |
| Chen, Q; Hou, X; Wang, S; Yuan, X; Zhang, B | 1 |
| Aronstam, RS; Chan, MH; Chao, PK; Huang, YW; Martin, AG; Martin, AL; Reichard, RA; Wang, HJ | 1 |
| Li, Q; Sun, M; Tang, Y; Wang, Y; Zhao, Y; Zheng, J; Zhou, J | 1 |
| Lee, JY; Lee, T; Park, SH; Song, KS; Yang, EJ | 1 |
| Cai, H; Chen, H; Chen, J; Deng, YC; Han, W; He, H; Tian, W; Xu, D; Zhou, M | 1 |
| Chae, JI; Jeon, YJ; Shim, JH | 1 |
| Chen, J; Dong, JX; Li, R; Liu, Y; Yu, QL; Yuan, L; Zhao, GY | 1 |
| Cai, L; Chen, L; Dong, Y; Lai, H; Li, Y; Liu, J; Ma, L; Qiu, N; Tang, M; Xie, C; Ye, H | 1 |
| Li, YL; Liang, N; Luo, HJ; Wang, GC; Wu, X; Yang, XX; Yang, YT | 1 |
| Chaudhary, A; Kumar Singh, U; Kumar, A | 1 |
| Chen, HC; Hwang, TL; Kuo, PC; Lee, EJ; Lee, KH; Shih, HC; Wu, TS | 1 |
| Foller, M; Herrmann, T; Jilani, K; Lang, F; Lupescu, A; Yang, W; Zbidah, M | 1 |
| Arbiser, JL; Banerjee, P; Basu, A; Pal, S | 1 |
| Chen, W; Hua, H; Shen, L; Sheng, Q; Teng, L | 1 |
| Chen, L; Dong, Y; Lai, H; Li, S; Liu, J; Ma, L; Peng, A; Qiu, N; Song, H; Tang, M; Yang, J; Zhang, Y | 1 |
| Arbiser, JL; Bonner, MY; Brady, C; Hawkins, AR; Lamb, HK; Lefkove, B; Lovat, PE; Martin, S; Redfern, CP; Thompson, P | 1 |
| Atanasov, AG; Baumgartner, L; Bu, J; Dirsch, VM; Fakhrudin, N; Gu, SP; Heiss, EH; Kramer, MP; Ladurner, A; Malainer, C; Noha, SM; Rollinger, JM; Schuster, D; Schwaiger, S; Stuppner, H; Vuorinen, A; Wang, JN | 1 |
| Chiu, CS; Lai, DW; Lan, KH; Pan, HC; Shen, CC; Sheu, ML; Wang, KB; Wu, SM | 1 |
| Chae, JI; Cho, SD; Cho, YS; Choi, JY; Choi, NJ; Jeon, YJ; Kim, DW; Ko, SM; Moon, HS; Noh, YW; Park, SM; Seo, KS; Shim, JH; Shin, JC | 1 |
| Cha, BY; Choi, MS; Jung, UJ; Kim, SR; Kim, YJ; Park, YB; Woo, JT | 1 |
| Chilampalli, C; Dwivedi, C; Fahmy, H; Hildreth, MB; Kaushik, RS; Young, A; Zeman, D; Zhang, X | 1 |
| Mukherji, M; O'Bryhim, BE; Ponnaluri, VK; Radel, J; Symons, RC; Vavilala, DT; White, RS | 1 |
| Chen, S; Fan, S; Li, X; Lin, J; Qi, G; Shan, J | 1 |
| Cho, YY; Choi, JH; Hong, SW; Jeong, HU; Kong, TY; Kwon, SS; Lee, HS; Lee, JY; Yeon, SH | 1 |
| Deng, KY; Liu, HY; Peng, T; Yu, JW; Zhu, BY | 1 |
| Chang, KC; Eun, SY; Joo, YN; Kim, HJ; Lee, JH; Park, SW | 1 |
| Kim, SK; Kim, YH; Lee, GH; Lee, JY; Lee, SY; Ma, JY; Oh, SJ | 1 |
| Arbiser, JL; Bonner, MY; Hahm, ER; Karlsson, AI; Singh, SV | 1 |
| Fan, BY; He, Y; Kong, LY; Wang, XB | 1 |
| Hu, C; Hu, J; Li, Z; Wang, Z; Zhu, X | 1 |
| Chan, DC; Chen, CF; Chen, YJ; Lan, KC; Liu, SH; Tsai, KS; Yang, RS | 1 |
| Alonso-Castro, AJ; Cerbón, MA; Domínguez, F; García-Carrancá, A; García-Regalado, A; González-Sánchez, I | 1 |
| Bauer, R; Bernaskova, M; Huefner, A; Kretschmer, N; Schuehly, W; Weis, R | 1 |
| Guo, Y; Han, M; Kuang, H; Wang, X; Wang, Y; Yu, X | 1 |
| Bai, P; Bian, Y; Cheng, Z; Liang, L; Wan, J; Wang, F; Wang, S; Xue, F | 1 |
| Arbiser, JL; Avtanski, DB; Bonner, MY; Nagalingam, A; Saxena, NK; Sharma, D | 2 |
| Fang, M; Li, L; Li, N; Lin, H; Wang, J; Xie, H; Yang, N | 1 |
| Chen, L; Dong, Y; Li, R; Qiu, N; Song, H; Tang, M; Wang, C; Wei, Y; Ye, H; Zhang, Y | 1 |
| Amin, AR; Arbiser, JL; Beitler, JJ; Bonner, M; Chen, ZG; Huang, W; Koenig, L; Lee, MJ; Nannapaneni, S; Shin, DM; Shin, HJ; Wang, H; Wang, X | 1 |
| Fan, JX; Guo, KY; Hung, YX; Wang, J; Xu, XJ; Ye, YB; Zhang, MW | 1 |
| Bu, Q; Liu, X; Liu, Y; Wang, Y; Zhu, Y | 1 |
| Cai, D; Cong, H; Hong, B; Li, G; Liu, J; Mu, G; Zhang, Q | 1 |
| An, Q; Chen, S; Cui, G; Liang, Y; Lin, Z; Wang, H; Wang, X; Zhang, W | 1 |
| Liu, S; Liu, Y; Liu, Z; Niu, X; Qi, Z; Wang, H; Wang, S; Xia, X | 1 |
| Chen, K; Chen, L; He, L; Li, S; Peng, A; Tang, H; Wang, W; Yang, J; Ye, H | 1 |
| An, C; Li, W; Liang, H; Ma, D; Ma, L; Su, Q; Wang, Q | 1 |
| Boelens, R; Brunsveld, L; Fuchs, S; Hirsch, AK; in het Panhuis, L; Lam, CV; Leysen, S; Milroy, LG; Nieto, L; Ottmann, C; Scheepstra, M; van Boeckel, CA; Wienk, H | 1 |
| Chao, JI; Lai, YJ; Lin, CI; Wang, CL | 1 |
| Baur, R; Schuehly, W; Sigel, E | 1 |
| Huo, G; Liao, Z; Shi, Q; Sun, X; Tang, X; Tang, Z; Wang, H; Xie, Y; Zhi, X | 1 |
| Hahm, ER; Sakao, K; Singh, SV | 1 |
| Li, N; Li, W; Sheng, YL; Shi, CH; Xu, HY; Xu, JH; Zhang, XR; Zhao, YQ | 1 |
| Chang, HT; Cheng, JS; Chiang, NN; Chou, CT; Jan, CR; Ko, KC; Kuo, DH; Liang, WZ; Shieh, P; Wu, RF | 1 |
| Cho, IJ; Jang, EJ; Jegal, KH; Jung, JY; Kang, SH; Kim, SC; Kim, YW; Ku, SK; Lee, JH; Lee, JR; Moon, SY; Park, SJ; Zhao, RJ | 1 |
| Jiang, G; Jiang, Z; Li, G; Liu, Q; Ren, X; Shi, M; Su, Q; Wang, H; Zhang, Y | 1 |
| Chen, CQ; Gao, SM; He, LC; Li, HY; Wu, JB; Ye, HG; Yin, LH | 1 |
| Hong, YS; Huo, Q; Lee, JK; Li, HM; Liu, H; Ma, T; Wu, CZ; Zhao, SR | 1 |
| Fan, T; He, L; Hu, J; Zhang, L | 1 |
| Gao, CF; Hu, J; Li, C; Ma, L; Rajput, NA; Wang, MH; Xiao, Y; Yang, J; Ye, YH; Zhang, YY | 1 |
| Kalyanaraman, B; Komas, SM; Liu, Q; Lubet, RA; Pan, J; Wang, Y; You, M; Zhang, Q | 1 |
| Deng, P; Hu, W; Jia, Y; Tang, Y; Tian, R; Xu, C; Zhang, L | 1 |
| Cho, YY; Jeong, HU; Kim, JH; Lee, HS | 1 |
| Kanjilal, D; Mukherji, M; Ponnaluri, VK; Vavilala, DT | 1 |
| Börtzler, J; Efferth, T; Greten, HJ; Kadioglu, O; Khalid, H; Kuete, V; Saeed, M | 1 |
| Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K | 1 |
| Anant, S; Jensen, RA; Kaushik, G; Kwatra, D; Mammen, JM; Subramaniam, D | 1 |
| Baur, R; Fuchs, A; Müller, CE; Schoeder, C; Sigel, E | 1 |
| Coppola, M; Mondola, R | 1 |
| An, Q; Chen, S; Jin, H; Li, J; Wang, A; Wen, J; Zhang, Q; Zhang, W | 1 |
| Anant, S; Jensen, RA; Kaushik, G; Mammen, JM; Ramamoorthy, P; Standing, D; Subramaniam, D; Umar, S; Venugopal, A | 1 |
| Ernst, M; Mihovilovic, MD; Puthenkalam, R; Rycek, L; Schnürch, M | 1 |
| Fan, JX; Guo, KY; Li, YM; Li, ZQ; Weng, GY; Wu, JW; Zeng, YJ; Zheng, R | 1 |
| Choi, EJ; Jun, SY; Kang, SH; Kim, HI; Kim, JA; Kim, Y; Park, DJ; Shin, OS; Son, SJ | 1 |
| Chao, TH; Chiu, CS; Jan, YJ; Lai, DW; Lee, WJ; Liu, CY; Liu, SH; Pan, HC; Peng, YC; Sheu, ML; Tien, HR; Wu, SM | 1 |
| Agacayak, E; Alabalik, U; Findik, FM; Gul, T; Icen, MS; Tunc, SY; Yuksel, H | 1 |
| Liao, K; Sun, L; Wang, D | 2 |
| Akae, H; Akagi, M; Akagi, R; Fukuishi, N; Fukuyama, Y; Hirashima, N; Matsui, N | 1 |
| Chang, KC; Kim, HJ; Kim, JH; Park, SW; Seo, MS | 1 |
| Chuang, SE; Hu, TS; Lai, GM; Lai, IC; Lai, TY; Lui, TN; Shih, PH; Wang-Peng, J; Yao, CJ; Yeh, CT | 1 |
| Deng, Y; Han, X; Kang, J; Tan, Z; Tang, S; Wang, M; Xiao, W; Zhou, C | 1 |
| Liu, J; Liu, Z; Sun, T; Xiang, Z; Zhang, C; Zhang, J | 1 |
| Chen, M; Cong, S; Ding, W; Hou, X; Lei, J; Li, G; Li, X; Meng, Y; Zhang, Y | 1 |
| Castillo, V; Cheng, S; Eliaz, I; Sliva, D | 1 |
| Arbiser, JL; Bonner, MY; Gius, D; Gupta, MP; Jones, DP; Kim, G; Pillai, VB; Raghuraman, H; Samant, S; Sundaresan, NR; Walker, DI | 1 |
| Xu, H; Yang, C; Zhi, X | 3 |
| Chae, JI; Chen, H; Cho, JH; Dong, Z; Jeon, YJ; Jung, S; Lee, TH; Park, H; Park, SM; Ryu, J; Shim, JH; Shin, JC | 1 |
| Chen, JN; Ip, SP; Lai, XP; Lin, ZX; Mao, QQ; Su, ZR; Xian, YF | 1 |
| Lai, R; Liu, T; Pan, Y | 1 |
| Jing-Ya, C; Jun-Jun, W; Xiao-Lei, M; Yong, C | 1 |
| Chen, JJ; Chien, CR; Lee, TY; Liao, HR; Lin, SZ; Tseng, CP | 1 |
| Guo, M; Liang, J; Meng, J; Wu, D; Wu, S | 1 |
| Gupta, NA; Katiyar, SK; Prasad, R; Singh, T; Velu, SE; Xu, S | 1 |
| Arbiser, JL; Avtanski, DB; Bonner, MY; Kuppusamy, P; Nagalingam, A; Saxena, NK; Sharma, D | 1 |
| Du, G; Guo, Y; Hu, K; Lu, Y; Yang, D; Yang, S; Zhou, H | 1 |
| Chen, SZ; Liu, F; Lv, X; Shang, Y | 1 |
| Li, S; Qiu, L; Qu, Y; Sheng, H; Wang, S; Wu, J; Xu, R | 1 |
| Feng, F; Liu, Y; Shi, Q; Wang, D; Yang, G | 1 |
| Chen, L; Cheng, X; Li, S; Pei, H; Qiu, N; Wang, W; Wang, X; Wen, J; Xie, C | 1 |
| Bian, ZX; Han, QB; Ho, HM; Hu, DD; Huang, T; Li, YH; Lin, CY; Lin, SH; Mi, H; Tan, HS; Xu, HX; Zhang, M; Zhao, L; Zhong, LL | 1 |
| Chen, T; Liao, H; Liu, M; Wang, J; Zhang, LY | 1 |
| Cheng, B; Guo, C; Huang, K; Ma, L; Peng, A; Zhao, Y; Zheng, L; Zhou, Q | 1 |
| Gao, WF; Wang, XD; Wang, YL | 1 |
| Chen, T; Hu, W; Jia, Y; Tang, Y; Tian, R; Yuan, P; Zhang, L; Zhang, Y | 1 |
| Jahng, KY; Jeong, SI; Kim, J; Kim, SY; Yu, KY | 1 |
| Chen, CL; Chen, SJ; Fang, CY; Huang, KJ; Lee, YR; Lin, CY; Ping, YH; Shiuan, D; Wu, HN | 1 |
| Baburin, I; Bernaskova, M; Hering, S; Hufner, A; Schoeffmann, A; Schuehly, W | 1 |
| Guo, N; Li, J; Li, W; Li, X; Liu, T; Liu, Z; Ma, W; Meng, R; Nie, D; Shi, C; Wang, W; Yu, L; Zhao, X; Zhao, Z | 1 |
| Amorati, R; Baschieri, A; Valgimigli, L; Zotova, J | 1 |
| Chang, YA; Chen, RM; Lin, CJ; Wang, JJ; Wang, W; Yeh, PS | 1 |
| Chen, M; Cong, S; Ding, W; Hou, X; Lei, J; Li, G; Li, X; Liu, Y; Meng, Y; Zhang, Y | 1 |
| Bi, L; Gao, S; Hong, G; Lu, Z; Wu, J; Yu, K; Yu, Z | 1 |
| Chang, C; Cui, Y; Eliaz, I; Guo, H; Huang, R; Huang, X; Li, Y; Shen, B; Shen, L; Song, J; Yan, J; Ye, C; Ying, H; Zhang, Q; Zhao, W; Zhuang, J | 1 |
| Alitongbieke, G; Cai, L; Chen, QC; Jiang, F; Liu, J; Meng, M; Ren, A; Shi, X; Su, Y; Wang, G; Wang, J; Xie, L; Xu, Y; Zeng, Z; Zhang, X; Zhang, XK; Zhou, H; Zhou, Y | 1 |
| Chen, D; Espinera, A; García, PS; Gu, X; Lee, JH; Wei, L; Woodbury, A; Yu, SP; Zhang, J | 1 |
| Domon, H; Fukuyama, Y; Kubo, M; Oda, M; Okiji, T; Sakaue, Y; Takenaka, S; Terao, Y | 1 |
| Guo, X; Huo, Q; Jin, W; Li, H; Li, J; Li, N; Ma, T; Wu, C | 1 |
| Bao, J; Chen, S; Jin, H; Li, W; Peng, B; Wang, A; Wang, L; Wei, J; Ye, X; Zhang, Q; Zhang, Y | 1 |
| Han, J; Li, YQ; Wang, GC; Zhang, XJ; Zuo, GY | 1 |
| Antoine, MH; Bunel, V; Duez, P; Nortier, J; Stévigny, C | 1 |
| Baruah, CC; Dwivedi, S; Gurjar, SS; Jangra, A; Kwatra, M; Lahkar, M; Sriram, CS; Sulakhiya, K | 1 |
| Li, M; Su, N; Xu, Y; Yu, H; Yu, Y; Zhang, Z; Zhao, H | 1 |
| Chen, CH; Chiang, CJ; Kuo, YJ; Tsai, TH; Wu, LC; Yang, CH | 1 |
| Guo, LP; Ming, MD; Shi, L; Yang, HB; Zhang, CC; Zhu, SD | 1 |
| Fu, X; Gao, X; Guo, Y; Hu, X; Huo, B; Li, W; Liu, Y; Sun, J; Wang, Y | 1 |
| Wu, JG; Wu, JY; Wu, YB; Yi, J | 1 |
| Choi, EM; Chon, S; Suh, KS | 1 |
| Kappes, JC; Katiyar, SK; Prasad, R | 1 |
| Das, S; Musgrave, IF; Pukala, T; Smid, SD; Stark, L | 1 |
| Jiang, LL; Liu, Z; Wang, Y; Wu, JF | 1 |
| Arbiser, JL; Arnold, RS; Bonner, MY; Karlsson, I; Rodolfo, M; Vergani, E | 1 |
| Deng, Y; Shen, H; Tian, W; Xiong, J; Xu, D; Zhu, S | 1 |
| Choi, WG; Jeong, HU; Kim, JH; Kong, TY; Lee, HS | 1 |
| Chao, WJ; Chen, RM; Chuang, SE; Huang, JS; Lai, GM; Lee, LM; Whang-Peng, J; Yao, CJ; Yeh, CT | 1 |
| Agacayak, E; Alabalik, U; Ekinci, A; Ekinci, C; Goruk, NY; Gul, T; Icen, MS; Togrul, C; Turgut, A; Yaman Tunc, S | 1 |
| Chang, CK; Chang, YA; Chen, RM; Lin, CJ; Lin, YL; Liu, SH | 1 |
| Chen, JY; Chen, Y; Cheng, YC; Huang, HY; Hueng, DY | 1 |
| Chang, YF; Chen, HC; Chi, CW; Hsia, CY; Hsu, HT; Lee, HC; Weng, JW | 1 |
| Hu, H; Hua, W; Wang, Z; You, Y; Zou, L | 1 |
| Ip, SP; Lin, ZX; Mao, QQ; Xian, YF | 1 |
| Mukherji, M; Subhani, S; Vavilala, DT | 1 |
| Chen, CY; Chen, PJ; Hwang, TL; Kuo, LM; Lin, CF; Shen, JJ; Tsai, YF; Wang, YL | 1 |
| Johnson, AB; Thulasiraman, P | 1 |
| Chen, RM; Chen, TL; Hsieh, MH; Lin, CJ; Lin, YW; Tseng, YY; Wu, GJ | 1 |
| Lee, Y; Pan, J; Wang, Y; You, M | 1 |
| Guo, N; Huang, YJ; Li, WL; Meng, RZ; Shi, C; Yu, L; Zhao, XC; Zhao, ZW; Zhu, XZ | 1 |
| Hahm, ER; Singh, KB; Singh, SV | 1 |
| Cai, ZJ; Chen, H; Lu, Y; Wang, XY; Wang, YD; Xiang, MX | 1 |
| Anandharaj, A; Hong, KH; Kassie, F; Kim, JH; Kirtane, AR; Panyam, J; Song, JM; Upadhyaya, P | 1 |
| Chen, F; Chen, Q; Deng, P; Feng, M; Ji, N; Jiang, L; Li, J; Li, L; Liao, G; Lin, Y; Liu, J; Xu, H; Zeng, X | 1 |
| Arbiser, JL; Bonner, MY; Cebula-Obrzut, B; Majchrzak, A; Mędra, A; Robak, T; Smolewski, P; Witkowska, M | 1 |
| Chen, SZ; Lv, XQ; Qiao, XR; Su, L | 1 |
| Ahmad, A; Arora, S; Averett, C; Bhardwaj, A; Carter, JE; Khan, MA; Khushman, M; Singh, AP; Singh, S; Srivastava, SK | 1 |
| Katiyar, SK; Prasad, R | 1 |
| Carda, M; Falomir, E; Marco, JA; Murga, J; Sánchez-Peris, M | 1 |
| Lee, Y; Pan, J; Wan, TC; Wang, Y; Xiong, D; You, M; Zhang, Q | 1 |
| Chen, L; Garrard, I; Hewitson, P; Ignatova, S; Peng, A; Sutherland, I; Ye, H; Zu, L | 1 |
| Katiyar, SK | 1 |
| Chang, YS; Chen, SH; Lee, YR; Lim, YP; Liu, YW; Lu, CH; Wu, JY; Yu, HI | 1 |
| Fang, J; Feng, J; Gao, S; Li, H; Lu, Z; Wu, J; Xing, C; Ye, H; Zhou, B | 1 |
| Chang, CC; Geraldine, P; Lee, TY; Li, JY; Lin, KH; Lu, WJ; Sheu, JR; Yen, TL | 1 |
| Gowda, AS; Spratt, TE; Suo, Z | 1 |
| Hang, C; Liao, K; Sun, L; Wang, D | 1 |
| Dwivedi, C; Guillermo-Lagae, R; Kaushik, RS; Santha, S; Stevens, J; Thomas, M; Zoelle, E | 1 |
| Arbiser, J; Bonner, MY; Costa, A; da Silva, MS; Eberlin, S; Facchini, G; Pinheiro, ALTA | 1 |
| Chen, X; Hao, K; Hu, Y; Shan, L; Wang, GX; Yu, X | 1 |
| Gao, X; Guo, G; Hu, X; Liu, X; Liu, Y; Mao, Q; Wang, X; Xu, G; You, C; Yu, T; Zhou, L | 1 |
| Doddapaneni, R; Godugu, C; Singh, M | 1 |
| Gong, C; He, T; Nie, S; Song, L; Wang, N; Wang, Z; Wu, Q; Yang, S; Yang, X; Yi, C | 1 |
| Arbiser, J; Fang, YH; Gupta, MP; Kanwal, A; Pillai, VB; Samant, S; Sharp, WW | 1 |
| Chen, H; Deng, F; Hu, W; Tang, Y; Zhang, L | 1 |
| Bu, P; Huang, C; Li, J; Li, N; Liu, H; Shan, X; Yan, X; Yang, Y; Zhang, C; Zhang, J; Zhang, P; Zhang, Y | 1 |
| Endo, M; Hori, M; Kaji, N; Mihara, T; Mikawa, S; Oikawa, T; Ozaki, H; Tong-Rong, J | 1 |
| Li, Y; Liang, Y; Zhu, X; Zou, S | 1 |
| Baccarin, J; Corkery, JM; Guarino, V; Orsolini, L; Papanti, DG; Schifano, F | 1 |
| Afthinos, A; Arbiser, JL; Begum, A; Bonner, MY; Cho, S; Győrffy, B; Huang, CY; Konstantopoulos, K; Korangath, P; Kuppusamy, P; Lanoue, D; Marignani, PA; Matsui, W; Merino, VF; Mistriotis, P; Muniraj, N; Nagalingam, A; Saxena, NK; Sengupta, S; Sharma, D; Shriver, M; Sukumar, S | 1 |
| Chen, GR; Cheng, L; Gu, LY; Ju, RJ; Li, XT; Liu, S; Song, XL; Wang, X; Xiao, Y; Zhang, SM | 1 |
| Wang, Z | 1 |
| Chan, S; Deora, GS; Dighe, SN; Kantham, S; Khabbazi, S; McColl, G; Miles, JA; Parat, MO; Ross, BP; Veliyath, SK | 1 |
| Liu, H; Zhong, X | 1 |
| Hu, C; Jiang, Q; Pan, H; Schachner, M; Shen, H; Xu, J | 1 |
| Balan, M; Chakraborty, S; Flynn, E; Pal, S; Zurakowski, D | 1 |
| He, BC; Jiang, HT; Liao, YP; Liu, RX; Ma, Y; Ren, WY; Sun, WJ; Wang, H; Wu, K; Zhu, JH | 1 |
| Chang, SH; Fang, JY; Hwang, TL; Lee, YT; Lin, CF; Liu, FC; Syu, YT; Yu, HP | 1 |
| Barreca, D; Braidy, N; Listos, J; Nabavi, SF; Nabavi, SM; Sureda, A; Talarek, S; Tellone, E | 1 |
| Deng, Y; He, C; Jin, Y; Li, X; Liu, Y; Qu, X; Wang, D; Wang, Z; Zhou, Y; Zou, Y | 1 |
| Li, Y; Ni, C; Song, G; Wang, M | 1 |
| Li, F; Qiu, Y; Wang, L; Wu, H; Yin, Z | 1 |
| Chen, H; Chen, YL; Gao, WY; Jin, ZX; Wang, L; Wang, SP; Zhang, JZ | 1 |
| Chen, L; Guo, Y; Huang, F; Huang, K; Huang, L; Long, Q; Yang, K; Yang, Q; Zhang, F; Zhang, K | 1 |
| Liu, Q; Qin, P; Shi, L; Wang, Q; Zhang, J | 1 |
| Arbiser, JL; Burd, EM; Chen, CW; Coopersmith, CM; Farris, AB; Ford, ML; Klingensmith, NJ; Liang, Z | 1 |
| Arbiser, JL; Iida, M; Kimple, RJ; McDaniel, NK; Nickel, KP; Orbuch, RA; Pearson, HE; Wheeler, DL | 1 |
| Chen, W; Wang, T; Wu, J | 1 |
| Lone, J; Yun, JW | 1 |
| Jiang, ZH; Li, CG; Li, CJ; Li, Z; Ni, CL; Sun, B; Tang, YZ; Yang, M; Zhu, YJ | 1 |
| Liao, K; Sun, LM | 1 |
| Li, G; Sheng, A; Zhang, G; Zhang, Y | 1 |
| Arbiser, JL; Beitler, JJ; Chen, AY; Chen, G; Chen, Z; Chen, ZG; Deng, X; Huang, W; Kim, S; Magliocca, K; Nannapaneni, S; Patel, MR; Qian, G; Saba, NF; Shin, DM; Wang, X; Zhang, J | 1 |
| Chen, X; Dong, H; Li, M; Li, Z; Liu, Y; Ma, M; Wu, Y; Zhao, Y | 1 |
| Kozlowski, MC; Lee, YE; Ochoa, C; Paniak, T; Solinski, AE; Wuest, WM | 1 |
| Lu, P; Sheng, J; Wang, Y; Zhao, D | 1 |
| Adamek, D; Amin, R; Briggs, G; Dhanasekaran, M; Govindarajulu, M; Heiner, J; Jones, E; Lynd, T; Majrashi, M; Moore, T; Ramesh, S; Suppiramaniam, V | 1 |
| Cheng, L; Ju, RJ; Li, CQ; Li, XT; Liu, S; Peng, XM; Qiu, X; Song, XL; Wang, T | 1 |
| Hur, HJ; Hwang, JT; Jeon, EJ; Jeong, YH; Lee, AS; Lee, KW; Park, SJ; Sung, MJ | 1 |
| Chen, SH; Huang, KJ; Kuo, CH; Lee, YR; Lin, CY | 1 |
| Arbiser, JL; Benevolenskaya, EV; Gaponenko, V; Gartel, AL; Halasi, M; Hitchinson, B; Khan, I; Shah, BN; Váraljai, R | 1 |
| Jiang, D; Yang, J; Zou, Y | 1 |
| Chen, T; Fu, Y; Gong, T; Huang, T; Li, W; Liu, X; Yang, Q; Zhang, Z | 1 |
| Deng, P; Feng, R; Ge, D; Song, Z; Sun, J; Teng, F; Wen, Y; Xu, H; Zhou, F | 1 |
| Chen, K; Chen, LJ; Cheng, XJ; Fu, SH; Lian, M; Peng, AH; Tang, H; Wang, ZL; Wu, B; Ye, HY; Zhang, Q | 1 |
| Chen, Y; Fang, X; Huang, K; Ma, Y; Shen, S; Wu, Y; Zhang, R | 1 |
| Basoli, V; Carta, P; Cruciani, S; Delogu, G; Dettori, MA; Fabbri, D; Maioli, M; Serra, PA | 1 |
| Liu, W; Zhu, X | 1 |
| Chen, K; Chen, LJ; Fu, J; Peng, A; Tang, H; Tang, MH; Wang, L; Wu, W; Xue, LL; Ye, H | 1 |
| Chen, Y; Wang, J; Zhai, T | 1 |
| Krahn, MP; Kullmann, L | 1 |
| Chang, CK; Chen, KY; Chen, RM; Chio, CC; Chuang, JY; Liu, CC; Liu, SH | 1 |
| Fan, SW; Gu, JM; Gu, Y; Hu, ZJ; Huang, KM; Jiang, XS; Jie, ZW; Tang, P; Wang, JY; Xie, ZA | 1 |
| Chen, S; Li, J; Qin, X; Wen, J; Yin, J; Zhang, W | 1 |
| Duan, W; Jiang, L; Jin, Z; Li, B; Li, K; Liang, H; Liu, Z; Yang, J; Yi, D; Yi, W; Yu, S; Zhai, M; Zhang, B; Zhang, M | 1 |
| Li, H; Pu, H; Sun, Q; Tang, B; Tang, P; Yang, H | 1 |
| Qiao, R; Xie, K; Xie, M | 1 |
| Deng, Y; Han, S; He, C; Jin, Y; Li, X; Liu, Y; Zhou, C; Zhou, Y; Zou, Y | 1 |
| Deng, Y; Han, X; Li, C; Tan, Z; Tang, S; Xiao, W | 1 |
| Ai, W; Gan, D; Liao, M; Liao, X; Wang, C; Wu, J | 1 |
| Chen, SZ | 1 |
| Hou, T; Jia, J; Li, H; Tian, Y; Wang, W; Wang, X; Wei, Y; Wu, Q; Xu, L | 1 |
| Chan, HL; Chien, YA; Chou, HC; Chuang, HH; Lee, YR; Liao, EC; Lin, LH; Lu, CH; Su, YC; Tsai, YT; Wei, YS; Yang, YT; Yu, HI; Yu, XR | 1 |
| Chan, MH; Chang, PC; Chen, C; Chen, HH | 1 |
| Liao, K; Sun, L | 2 |
| Hong, SH; Kim, BK; Kim, DD; Kim, KS; Kim, SB; Park, JW; Ryu, HM; Yoon, IS | 1 |
| Diomede, L; Kirika, N; Romeo, M; Salmona, M; Sarrica, A | 1 |
| Fang, J; Hou, Y; Li, X; Peng, S; Xu, J; Yao, J | 1 |
| Hong, T; Hui, Z; Liang, XZ; Lixing, Y; Min, H; Yuejian, L | 1 |
| Lin, LG; Liu, JX; Shen, SN; Tong, Q; Wang, YT | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Ozaki, K | 1 |
| Luo, H; Wu, Q; Yi, T; Zhang, M | 1 |
| Cheng, L; Fu, M; Ju, RJ; Li, XT; Liu, JJ; Wang, X; Xiao, Y; Xie, HJ | 1 |
| Chang, MT; Fang, CY; Hsieh, PL; Lee, SP; Liao, YW; Liu, CM; Lu, MY; Tsai, LL; Yu, CC | 1 |
| Ahmad, N; Al-Showiman, SS; Arshad, MU; Elsharkawy, E; Imran, M; Maalik, A; Mabkhot, YN; Patel, S; Rauf, A; Saeed, F | 1 |
| Cai, J; Li, D; Li, Y; Liang, Y; Wu, Z; Xie, Z; Zhou, F; Zhou, Y; Zhu, X | 1 |
| Han, F; Lu, X; Xu, J | 1 |
| Chen, L; Li, W; Lu, L; Qi, D; Wang, D; Zhang, Z | 1 |
| Arnold, P; Cossais, F; Heimke, M; Lucius, R; Preuße-Prange, A; Rickert, U; Wilms, H | 1 |
| Lappas, M; Wijesuriya, YK | 1 |
| Chen, RM; Chio, CC; Liu, SH; Mohanraj, M; Tai, YT; Yang, ST | 1 |
| Chan, MH; Chang, PC; Chen, C; Chen, HH; Chen, PM; Wey, SP | 1 |
| Liu, P; Wang, L; Wang, S; Wu, W; Zhao, X; Zu, Y | 1 |
| Bernaskova, M; Hufner, A; Miller, GW; Schuehly, W; Stout, K | 1 |
| Chen, L; Lei, SQ; Lu, YY; Peng, M; Xia, ZY; Ye, JS | 2 |
| Dang, L; Dong, CL; Xiao, G; Yang, R | 1 |
| Huang, Y; Li, S; Liu, C; Liu, S; Liu, Z; Wang, Y | 1 |
| Arbiser, JL; Chiu, CS; Hsieh, MS; Hsing, HY; Jan, YJ; Lai, DW; Lin, WY; Sheu, ML; Tsai, CH; Tsai, SC; Wu, SM | 1 |
| Chen, D; Duan, Y; Hu, J; Huang, C; Huang, Q; Jin, H; Lin, D; Nisar, M; Pan, X; Tian, N; Wang, J; Wang, K; Wang, X; Wu, C; Yan, Y; Zhang, X; Zheng, G | 1 |
| Chen, L; Hewitson, P; Ignatova, S; Peng, A; Sutherland, I | 1 |
| Jung, JK; Kim, SY; Lim, D; Seo, SY; Subedi, L; Yuan, Y | 1 |
| Bao, Z; Cen, M; Cui, L; Fang, L; Lu, G; Yang, G; Yao, Y; Zhou, J | 1 |
| Chen, L; Li, W; Wang, D | 1 |
| Chen, J; Du, GH; Hu, AX; Lian, WW; Lin, D; Liu, AL; Xiao, MW; Ye, J; Yi, YJ | 1 |
| Chen, J; Guan, J; Huang, Z; Liu, X; Qian, J; Qu, W; Wang, J; Wang, T; Xu, X; Yang, Y; Zhan, C | 1 |
| Fan, S; Li, N; Lin, H; Liu, H; Lu, Z; Wang, H; Xia, S | 1 |
| Guo, Y; Han, M; Liu, B; Wang, X; Yu, R; Zou, Y | 1 |
| Feng, J; Gao, W; Xu, S; Zhao, G; Zhu, J | 1 |
| Duan, Q; Li, Q; Ma, C; Mao, M; Wang, X; Xiao, D; Zhang, L; Zheng, X; Zhu, D | 1 |
| Deng, S; Ma, L; Yang, L; Zhang, C | 1 |
| Xiang, L; Zhang, T | 1 |
| Çetin, A; Deveci, E | 1 |
| Eble, JA; Heemskerk, JWM; Nagy, M; Onselaer, MB; Pallini, C; Perrella, G; Pike, JA; Poulter, NS; Quintanilla, LG; Watson, SP | 1 |
| Cha, EY; Ko, YB; Lee, JS; Lee, MS; Park, JB; Sul, JY | 1 |
| Li, L; Liang, X; Liu, S; Tan, L | 1 |
| Fu, Q; Guo, K; Shi, S; Tong, C; Xiao, Y; Xu, J | 1 |
| Ali, H; Khalid, S; Khan, A; Khan, S; Kim, YS; Shal, B | 1 |
| Ding, D; Kai, L; Sun, L; Ye, X | 1 |
| Arfuso, F; Banik, K; Bordoloi, D; Deshpande, V; Fan, L; Kunnumakkara, AB; Nalawade, SP; Padmavathi, G; Ranaware, AM; Sailo, BL; Sethi, G; Shanmugam, MK | 1 |
| Bao, J; Chen, S; Jin, H; Li, H; Li, W; Wang, A; Wei, J; Yang, C; Zhang, Q | 1 |
| Chen, A; He, S; Ling, Y; Liu, H; Song, X; Tan, Z; Wang, S; Wang, X; Yan, J; Yan, Y | 1 |
| Chen, JT; Chen, RM; Lee, YW; Lin, MC; Lin, YW; Liu, SH; Tseng, YY | 1 |
| Guo, N; Hao, K; Liu, C; Liu, Z; Wang, J; Yan, Z | 1 |
| Wu, JW; Yu, FL; Zhu, H | 1 |
| Chang, HS; Hu, KL; Li, LN; Lu, Y; Wang, PP; Yu, X; Zhang, B | 1 |
| An, DR; Chen, YH; Guo, DS; Lu, MH; Miao, D; Yuan, CH; Yue, JY; Zhai, YY; Zhao, MM | 1 |
| Ding, Z; Fu, R; Shen, W; Wan, Y; Zhang, J; Zhang, Y; Zhen, Y | 1 |
| Chen, SZ; Li, Y; Shang, Y; Wang, WD | 1 |
| Do, HTT; Fei, X; Lee, C; Lee, SH; Rhee, I; Seo, SY | 1 |
| Chen, A; Hu, A; Lin, D; Liu, J; Peng, J; Wu, X; Yan, Z; Ye, J | 1 |
| Gao, CY; Guo, S; Han, JY; Wei, N; Xu, JJ; Xu, PS; Xue, R | 1 |
| Bayan, P; Jiraviriyakul, A; Kaewthet, P; Pongcharoen, S; Songjang, W; Tanawatkitichai, P | 1 |
| Balmas, V; Carta, P; Delogu, G; Dettori, MA; Fabbri, D; Malbrán, I; Migheli, Q; Oufensou, S; Pani, G; Scherm, B | 1 |
| Hardisty, S; Kerr, K; McAlister, K; McCullough, I; Thulasiraman, P; Wistner, A | 1 |
| Dekarske, MM; Kozlowski, MC; Nowlan, M; Ochoa, C; Solinski, AE; Wuest, WM | 1 |
| Hiratsuka, A; Izawa, T; Masuda, Y; Nishiyama, T; Ogura, K; Ohnuma, T | 1 |
| Fu, J; Huang, PP; Liu, HX; Liu, LH; Liu, Y; Qi, BL; Qi, BM; Wu, KF | 1 |
| Teng, X; Wang, S; Wang, Y; Yuan, Y; Zhou, X | 1 |
| El-Demerdash, E; Elfeky, MG; Fawzy, HM; Gad, AM; Mantawy, EM | 1 |
| Kubatka, P; Kwon, TK; Min, KJ; Seo, SU; Woo, SM | 1 |
| Dai, Y; Huang, X; Li, B; Li, HM; Li, Y; Ma, H; Wang, H; Wu, CZ; Zhu, M | 1 |
| Deng, X; Guo, Y; Lu, N; Lv, X; Wang, J; Wang, Y; Zhou, Y | 1 |
| Cai, N; Jin, X; Yang, Q; Zhang, Z | 1 |
| Lu, X; Lv, H; Zhang, Z | 1 |
| Jin, J; Kang, KP; Kim, W; Park, SK; Park, W; Quan, Y | 1 |
| Chen, T; Cui, X; Li, B; Ma, D; Tian, S; Xu, Y; Zhang, Z | 1 |
| Arbiser, J; Fan, S; Owonikoko, TK; Qian, G; Ramalingam, SS; Sun, SY; Zang, H | 1 |
| Chen, HT; Hsiao, YP; Hsu, CC; Huang, CH; Huang, KH; Jan, TR; Liang, HJ; Liang, YC; Wang, TE | 1 |
| Bale, S; Godugu, C; Pulivendala, G | 1 |
| Aghi, MK; Chandra, A; Chen, W; Diaz, AA; Garcia, JH; Gilbert, LA; Jahangiri, A; Jain, S; Joshi, RS; Kumar, S; Lin, JG; Müller, S; Nguyen, AT; Pereira, MP; Rick, JW; Shah, SS; Wadhwa, H; Weiss, J; Wolf, KJ; Yagnik, G | 1 |
| Barresi, V; Cardullo, N; Condorelli, DF; D'Amico, M; Muccilli, V; Spampinato, G; Tringali, C | 1 |
| Copmans, D; de Witte, P; Hunyadi, B; Li, J; Luyten, W; Partoens, M | 1 |
| He, K; Jiang, M; Li, J; Liu, Q; Qiu, T; Sun, J; Yang, M; Zhan, S; Zhang, X | 1 |
| Feng, N; Guo, J; Guo, T; He, Y; He, Z; Hou, X; Liu, Y; Zhang, J; Zhang, Y | 1 |
| Cao, H; Jiang, LY; Li, T; Song, LL; Wang, Y; Yang, C; Zhi, XY | 1 |
| Chen, RM; Wu, GJ; Yang, ST | 1 |
| Hafiz, AA; Haggag, YA; Ibrahim, RR | 1 |
| Bennett, B; Bui, D; Cheng, G; Feng, L; Hu, M; Kalyanaraman, B; Kim, YH; Myers, CR; Pan, J; Schmainda, K; Shin, SS; Wang, Y; Xiong, D; You, M; Zhang, Q; Zielonka, J | 1 |
| Huang, J; Lai, W; Li, CM; Li, M; Li, Y; Lou, TQ; Peng, H; Ye, ZC | 1 |
| Gao, H; Huan, Y; Lin, J; Peng, X; Zhan, L; Zhang, Y; Zhao, G; Zhu, Y | 1 |
| Cheng, P; Liu, Y; Wu, AH | 1 |
| Arbiser, JL; Colombo, G; Elsey, J; Ferraro, M; Masgras, I; Menon, D; Moroni, E; Rasola, A; Sanchez-Martin, C | 1 |
| Benigni, A; Bolognini, S; Cassis, P; Corna, D; Locatelli, M; Novelli, R; Perico, L; Remuzzi, G; Villa, S; Zanchi, C; Zoja, C | 1 |
| Chen, J; Li, D; Lv, B; Qin, S; Wang, D; Xu, D; Xu, F; Zhang, W; Zhang, Y; Zhang, Z | 1 |
| Cai, D; Fan, L; Guan, S; Liu, D; Wang, J; Zhang, Q; Zhu, W | 1 |
| Caballero, EP; Corral, RS; Mariz-Ponte, N; Rigazio, CS; Santamaría, MH | 1 |
| Chan, MH; Chen, HH; Lo, YC; Wu, SN | 1 |
| Fulczyk, A; Kowalska, T; Móricz, ÁM; Ott, PG; Sajewicz, M; Łata, E | 1 |
| Chen, P; Hu, Y; Zhang, H; Zhou, J | 1 |
| Chi, Z; Guo, E; Kim, D; Kim, JH; Le, TPH; Lee, S; Lee, SK; Lee, SY; Seo, SY | 1 |
| Chen, C; Chen, P; Chen, Y; Li, M; Lu, H; Zhu, S | 1 |
| Im, E; Jung, JH; Kim, SH; Lee, HJ; Lee, IH; Lee, JH; Park, JE; Shim, BS; Sim, DY | 1 |
| Wu, W; Xue, W | 1 |
| Fang, Z; Lu, P; Sheng, J; Wang, Y; Wei, X | 1 |
| Chen, A; Hsu, WH; Hua, KF; Ka, SM; Liu, FC; Shang, HS; Wu, CY; Yang, SR | 1 |
| Chen, W; Jin, X; Li, F; Li, H; Li, Q; Liu, B | 1 |
| Mao, G; Xu, J; Yan, Y | 1 |
| Aparicio, CNM; Heather, LC; Kerr, M; Miller, JJ; Scott, I; Stiewe, S; Thapa, D; Timm, KN; Tyler, DJ | 1 |
| Chen, L; Qu, Z; Tang, K; Zhang, Y | 1 |
| He, BC; Li, Q; Liu, XL; Ma, Y; Mu, L; Sun, WJ; Wu, K | 1 |
| Chen, CG; Jiang, Q; Li, J; Li, XQ; Long, WG; Ren, J; Su, JY; Wang, Y; Zhu, YM | 1 |
| Di, G; Fan, J; Guo, C; Li, Q; Wang, J; Wei, D; Wu, X; Yang, H | 1 |
| Chiu, KC; Hsia, SM; Jhuang, HS; Lan, WC; Li, PJ; Shen, YW; Shieh, TM; Shih, YH; Wang, TH; Yuan-Chien Chen, M | 1 |
| Du, SS; He, YH; Hu, GF; Li, HX; Liu, H; Liu, YQ; Qin, F; Shang, XF; Wang, YL; Wu, TL; Yan, YF; Yang, CJ; Zhao, WB; Zhao, ZM; Zhou, R | 1 |
| Fan, P; Li, C; Lou, H; Shi, X; Song, H; Zhang, T | 1 |
| Chang, HS; Duan, XH; Hu, KL; Li, LN; Li, Y; Liu, M; Yu, X; Zhang, B | 1 |
| Cassaidy, BJ; Chon, AC; Escalante-Buendia, Y; Esser-Kahn, AP; Moser, BA; Naorem, N; Nguyen, MH; Rosenberger, MG; Steinhardt, RC; Tran, NT | 1 |
| Li, X; Liao, G; Yang, H; Zhao, Z | 1 |
| Huang, W; Li, Y; Liu, H; Mai, G | 1 |
| Han, X; Jin, H; Liu, C; Qi, F; Qian, T; Sun, J; Wang, Q; Xu, D; Zeng, W | 1 |
| Das, S; Jovcevski, B; Pukala, TL; Smid, S | 1 |
| Chu, C; Jiang, L; Li, J; Liu, C; Wang, S; Weng, L; Yan, J; Zhang, H | 1 |
| Feng, Y; Guo, J; Guo, M; Liu, Y; Ren, C; Tan, Y; Wang, J; Wu, X | 1 |
| Balan, M; Bhowmick, S; Chakraborty, S; Hamedani, Y; Pal, S; Sabarwal, A | 1 |
| Chen, Y; Liu, Y; Qian, K; Xiong, Y; Xu, W; Zhai, T | 1 |
| Andrews, NG; Deb, A; Raghavan, V | 1 |
| Buabeid, M; Dhanasekaran, M; Dwyer, D; Fabbrini, M; Fujihashi, A; Govindarajulu, M; Lynd, T; Mohanakumar, KP; Moore, T; Neel, L; Ramesh, S; Shah, K; Smith, F | 1 |
| Cai, Y; Cao, Y; Chai, Y; Chen, L; Chen, X; Hong, Z; Liu, Y; Shi, Y; Wang, D; Zhu, Z | 1 |
| Gopala, S; Jayakumari, NR; Parambil, ST; Rajendran, RS; Reghuvaran, AC; Sivasailam, A; Sreelatha, HV | 1 |
| Lou, L; Wang, J; Xiong, J; Yi, X; Zhou, S | 1 |
| Bian, Y; Cai, D; Gu, Y; Li, Y; Liu, X; Xue, M; Zhang, L; Zhang, Z; Zhao, Y | 1 |
| Choe, W; Ha, J; Jeong, S; Kang, I; Kim, KY; Kim, S; Lee, YS; Yoon, JS; Yoon, KS | 1 |
| An, J; Dong, Z; Guo, C; He, C | 1 |
| Gan, S; Gong, R; Ma, L; Mou, KJ; Sun, S; Tan, Y; Wu, J; Xu, S; Xue, J; Yu, H | 1 |
| Biagi, M; Borgonetti, V; Galeotti, N; Governa, P; Manetti, F; Miraldi, E | 1 |
| Meng, Y; Ye, H | 1 |
| Chen, PY; Ho, DC; Hsieh, PL; Liao, YW; Lu, KH; Su, SH; Tsai, LL; Yu, CC | 1 |
| Abbaszadeh, H; Mottaghi, S | 1 |
| Jia, J; Jia, L; Jiao, H; Kong, C; Li, B; Li, W; Li, Y; Pang, Y; Qin, W; Wang, S; Wang, Y; Xu, L; Zhang, H | 1 |
| Li, J; Liang, K; Liao, L; Tao, S; Yang, J; Yang, X; Zeng, S; Zhang, M; Zhou, J | 1 |
| Bai, L; Chen, Z; Gao, K; Liu, M; Luo, S; Ma, K; Wang, H; Wang, T; Wu, S; Xiao, Q; Yang, F | 1 |
| Anant, S; Dandawate, P; Jensen, RA; Kwatra, D; Ponnurangam, S; Ramalingam, S; Subramaniam, D; Umar, S; Weir, SJ | 1 |
| Chen, C; Lin, LG; Ye, Y; Zhang, QW | 1 |
| Chen, Y; Hu, X; Li, J; Li, Y; Qu, J; Wang, D; Wang, Z; Xia, M; Yuan, R; Zhang, H; Zhang, Y | 1 |
| Alhumaydhi, FA; Aljohani, ASM; Emran, TB; Imran, M; Kamal, MA; Khan, SA; Khayrullin, M; Mitra, S; Olatunde, A; Rauf, A; Rebezov, M; Shariati, MA; Uddin, MS | 1 |
| Hu, Q; Lou, GG; Luo, YT; Xie, LP; Yao, HP | 1 |
| Bai, LP; Guo, Y; Jin, J; Liu, J; Liu, Z; Tian, W; Xu, T; Zhang, Q | 1 |
| ElMeshad, A; Ezzeldeen, Y; Sebak, A; Swidan, S | 1 |
| Cao, H; Ding, H; He, W; Jiang, L; Luo, J; Wen, P; Yang, J; Zen, K; Zhang, Y; Zhou, Y | 1 |
| Dong, Z; Guo, Y; Han, M; Qiu, H; Wang, R; Wang, X | 1 |
| Abu-Serie, MM; Darwish, AI; Haiba, NS; Khalil, HH; Khattab, SN; Osman, HA; Teleb, M | 1 |
| Abdel-Ghaffar, HA; Abdellatif, H; Ashry, R; Elhussiny, M; Elkashty, O; Gaballa, ET; Mousa, SA | 1 |
| Jiang, D; Liu, J; Liu, X; Pan, Y; Qiu, Y; Shi, Y; Wan, H; Wang, P; Ying, K; Zhu, Y | 1 |
| Kurutas, EB; Secinti, IE; Secinti, KD | 1 |
| Cai, H; Li, Y; Liu, X; Wang, L; Yang, Q; Zhao, X | 1 |
| Aleksandrov, AG; Gomzina, NA; Kiseleva, MM; Kuzmich, NN; Kuznetsova, OF; Sivak, KV; Stosman, KI; Vaulina, DD; Viktorov, NB | 1 |
| Chen, C; Fu, P; Guo, F; Lan, X; Li, L; Luo, R; Ma, L; Wang, Y; Zhang, C | 1 |
| Wu, W; Xu, H | 1 |
| Chen, SY; Hou, YC; Li, PY; Lin, SP; Yu, CP | 1 |
| Balan, M; Briscoe, DM; Chakraborty, S; Flynn, E; Liu, K; Pal, S; Sabarwal, A; Wedel, J; Zurakowski, D | 1 |
| Huang, YF; Ip, SP; Li, QP; Lin, ZX; Qu, C; Su, ZR; Xian, YF; Xie, YL; Xu, QQ; Yang, W; Yuan, QJ | 1 |
| Gao, W; Han, X; Huang, L; Ji, H; Li, X; Liu, C; Wang, J; Wang, W; Zhang, X | 1 |
| Im, DS; Lee, JH | 1 |
| Cai, D; Guan, S; Li, D; Liu, D; Wang, J; Xing, G; Yue, L; Zhang, Q | 1 |
| Bai, G; Gao, J; Jiang, M; Niu, L; Shen, F; Wang, J | 1 |
| Cheng, P; Cheng, TT; Huang, AL; Ji, XL; Liao, DY; Ma, L; Peng, DD; Xia, XG; Yang, F; Zhang, L; Zhou, L | 1 |
| Cao, Y; Dai, X; Li, X; Liang, Y; Liu, K; Lu, J; Wang, X; Xie, L; Zhang, X | 1 |
| Chen, H; Chen, Y; He, A; Hu, Y; Li, X; Luo, M; Lv, D; Sasmita, BR; Shen, J; Yu, H; Zhuang, R | 1 |
| Kalyanaraman, B | 1 |
| He, SP; Lan, JG; Mao, RW; Zhu, WZ | 1 |
| Chen, B; Kong, Q; Li, Z; Lv, L; Zhang, Y | 1 |
| Lu, X; Lv, H; Yang, P; Zhang, Z | 1 |
| Du, K; Jia, Y; Li, Y; Liu, Y; Luo, Y; Wang, B; Wang, Z; Yang, J; Yang, S; Zhu, B | 1 |
| Bai, LP; Cheng, W; Chu, J; Guo, Y; Liu, JZ; Ma, N; Meng, JR; Xu, T; Zhang, Q | 1 |
| Elbarbry, F; Moshirian, N | 1 |
| Hu, S; Hu, Y; Luo, Z; Pan, L; Shen, C; Wang, S; Xu, T; Yang, C; Yao, Y; Zhao, Y | 1 |
| Li, Y; Liang, C; Zhou, X | 1 |
| Cao, L; Fan, H; Hao, X; Ma, Y; Wang, D; Wang, G; Zhou, X | 1 |
| Chen, F; Chen, J; Ji, L; Liu, F; Qin, Y; Wang, S; Wang, Y; Wu, P; Xue, J | 1 |
| Hou, L; Kang, L; Li, H; Nan, T; Rong, P; Sun, J; Wang, W; Yang, B; Yang, W; Zhang, J | 1 |
| Adhya, I; Chakrabarti, R; Chall, S; Delacroix, T; Errasti, G; Ghosh, A; Gitton, G; Guan, X; Krishna Dumpati, R; Reverdy, C; Roy, S | 1 |
| Hu, Y; Li, B; Lv, Y; Wei, S; Zhang, S; Zhang, W | 1 |
| Deng, Y; Hu, T; Lei, L; Ren, S; Xia, M; Yang, Y; Zuo, Y | 1 |
| Amorati, R; Baschieri, A; Cardullo, N; Monti, F; Muccilli, V | 1 |
| Biotti, G; Budriesi, R; Buzzi, R; Corazza, I; Fontana, R; Frosini, M; Gotti, R; Manfredini, S; Marconi, P; Mattioli, LB; Micucci, M; Vertuani, S | 1 |
| Cardullo, N; Di Francesco, A; Muccilli, V; Pulvirenti, L; Sciacca, C | 1 |
| Hu, Y; Liu, B; Tang, Y; Wang, T; Wang, Z; Zhang, J; Zhang, M; Zheng, J | 1 |
| Mu, HJ; Sun, YL; Wang, J; Wang, Y; Yuan, B | 1 |
| Prasher, P; Sharma, M | 1 |
| Gao, Y; Heng, W; Huang, M; Pang, Z; Qian, S; Su, M; Wei, Y; Zhang, J | 1 |
| Feng, YF; Hu, ZQ; Ming-Xin Guo, MM; Wu, X | 1 |
| Fan, XC; Lu, TL; Mao, CQ; Qi, YF; Su, YA; Wang, SC; Zhang, KW | 1 |
| Alshahrani, AM; Ateşşahin, DA; Calina, D; Fatima, R; Prasher, P; Sharifi-Rad, J; Sharma, M; Tynybekov, B | 1 |
| He, X; Wang, S; Wei, F; Zhang, M | 1 |
| Deng, Q; Shang, J; Wang, X; Wei, D; Yang, J; Yang, L; Ye, Y; Zhong, Z; Zhou, M | 1 |
Reviews
31 review(s) available for honokiol and lignans
| Article | Year |
|---|---|
[A brief review of chemical studies of the medicinal plant houpo].
Topics: Alkaloids; Biphenyl Compounds; Chromatography; Drugs, Chinese Herbal; Lignans; Oils, Volatile | 1989 |
Honokiol, a multifunctional antiangiogenic and antitumor agent.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antiviral Agents; Biphenyl Compounds; Cell Line, Tumor; Lignans; Mice; Reactive Oxygen Species | 2009 |
Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.
Topics: Antioxidants; Biphenyl Compounds; Dermatologic Agents; Drugs, Chinese Herbal; Humans; Lignans; Skin Diseases | 2010 |
Honokiol: a novel natural agent for cancer prevention and therapy.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; ErbB Receptors; Humans; Lignans; Magnolia; Mice; Neoplasms; NF-kappa B; Plant Preparations; Rats; Signal Transduction; STAT3 Transcription Factor; TOR Serine-Threonine Kinases | 2012 |
Honokiol, a multifunctional tumor cell death inducer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Death; Cell Movement; Drug Resistance, Neoplasm; Humans; Lignans | 2012 |
Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Caspases; Humans; Lignans; Magnolia; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Signal Transduction; Structure-Activity Relationship; TOR Serine-Threonine Kinases | 2013 |
Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biphenyl Compounds; Cells, Cultured; Dietary Supplements; Hippocampus; Humans; Lignans; Magnolia; Mice; Molecular Weight; Nerve Growth Factors; Neurodegenerative Diseases; Neurogenesis; Phytotherapy; Polyphenols; Rats; Structure-Activity Relationship; Zingiberales | 2015 |
Advances on Semisynthesis, Total Synthesis, and Structure-Activity Relationships of Honokiol and Magnolol Derivatives.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line; Humans; Isomerism; Lignans; Magnolia; Plant Bark; Structure-Activity Relationship | 2016 |
HIF inhibitors for ischemic retinopathies and cancers: options beyond anti-VEGF therapies.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Anthracyclines; Biphenyl Compounds; Cardiac Glycosides; Humans; Hypoxia-Inducible Factor 1; Indazoles; Lignans; Models, Biological; Neoplasms; Neovascularization, Pathologic; Retinal Neovascularization; Vascular Endothelial Growth Factors | 2016 |
Honokiol targets mitochondria to halt cancer progression and metastasis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Humans; Lignans; Magnolia; Mitochondria; Neoplasms; Plant Extracts; Polyphenols | 2016 |
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Topics: Animals; Biphenyl Compounds; Cardiovascular Diseases; Enzyme Induction; Humans; Lignans; Oxidative Stress; Reactive Oxygen Species; Sirtuin 3 | 2016 |
Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Proliferation; Humans; Lignans; Neoplasms; Signal Transduction; Ultraviolet Rays | 2016 |
Emerging Phytochemicals for the Prevention and Treatment of Head and Neck Cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Catechin; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Evaluation, Preclinical; Head and Neck Neoplasms; Humans; Lignans; Magnolia; Polyphenols; Proanthocyanidins; Squamous Cell Carcinoma of Head and Neck; Tea; Vitis | 2016 |
Is there a potential of misuse for Magnolia officinalis compounds/metabolites?
Topics: Biphenyl Compounds; Humans; Lignans; Magnolia; Plant Bark; Plant Extracts; Substance-Related Disorders | 2017 |
Neuroprotective effects of honokiol: from chemistry to medicine.
Topics: Amyloid beta-Peptides; Antioxidants; Biological Products; Biological Transport; Biphenyl Compounds; Blood-Brain Barrier; Central Nervous System; Cytokines; Gene Expression Regulation; Humans; Lignans; Magnolia; Nerve Growth Factors; Neurodegenerative Diseases; Neuroprotective Agents; Plant Bark; Receptors, Glutamate | 2017 |
Controlling the master-upstream regulation of the tumor suppressor LKB1.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Biphenyl Compounds; Calcium-Binding Proteins; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lignans; Lung Neoplasms; Lysosomes; Mutation; Peutz-Jeghers Syndrome; Phosphorylation; Protein Serine-Threonine Kinases; Sumoylation; Ubiquitination | 2018 |
[Research progress in anticancer effects and molecular targets of honokiol in experimental therapy].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Synergism; Humans; Lignans; Neoplasms; Signal Transduction; Therapies, Investigational | 2016 |
Safety and Toxicology of Magnolol and Honokiol.
Topics: Animals; Biphenyl Compounds; Drug Interactions; Humans; Lignans; Magnolia; Mutagenicity Tests; Plant Extracts; Tissue Distribution | 2018 |
Honokiol: An anticancer lignan.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Humans; Lignans; Treatment Outcome | 2018 |
Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Humans; Lignans; Magnolia; Molecular Targeted Therapy; Neoplasms | 2019 |
Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis.
Topics: Biphenyl Compounds; Humans; Lignans; Magnolia; Medicine, Chinese Traditional | 2020 |
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Biphenyl Compounds; Dietary Supplements; Drug Delivery Systems; Enzyme Inhibitors; Glucosides; Humans; Hydrazines; Indazoles; Lignans; Neuroprotection; Phenols; Sirtuin 3 | 2021 |
Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review.
Topics: Antineoplastic Agents; Biphenyl Compounds; Humans; Lignans | 2022 |
Honokiol: A review of its pharmacological potential and therapeutic insights.
Topics: Animals; Biphenyl Compounds; Humans; Lignans; Magnolia; Plant Extracts | 2021 |
The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms.
Topics: Biphenyl Compounds; Humans; Lignans; Signal Transduction | 2023 |
Exploiting the tumor immune microenvironment and immunometabolism using mitochondria-targeted drugs: Challenges and opportunities in racial disparity and cancer outcome research.
Topics: Atovaquone; Biphenyl Compounds; Black People; Health Status Disparities; Hispanic or Latino; Humans; Immune Checkpoint Inhibitors; Lignans; Mitochondria; Neoplasms; Oxidative Phosphorylation; Tumor Microenvironment | 2022 |
The application prospects of honokiol in dermatology.
Topics: Allyl Compounds; Antioxidants; Biphenyl Compounds; Dermatology; Humans; Lignans; Phenols; Skin Diseases | 2022 |
Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism.
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Lignans; Lung Neoplasms; Signal Transduction | 2023 |
Research Progress on the Structural Modification of Magnolol and Honokiol and the Biological Activities of Their Derivatives.
Topics: Biphenyl Compounds; Lignans; Magnolia; Structure-Activity Relationship | 2023 |
Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship.
Topics: Biphenyl Compounds; Cell Line, Tumor; Humans; Lignans; Neoplasms; Phenols; Structure-Activity Relationship | 2023 |
Nanotechnology-Based Drug Delivery Systems for Honokiol: Enhancing Therapeutic Potential and Overcoming Limitations.
Topics: Biphenyl Compounds; Drug Delivery Systems; Lignans; Micelles; Nanoparticles; Nanotechnology | 2023 |
Trials
1 trial(s) available for honokiol and lignans
| Article | Year |
|---|---|
Modulating testosterone pathway: a new strategy to tackle male skin aging?
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Aromatase; Biphenyl Compounds; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Lignans; Magnolia; Male; Middle Aged; Skin Aging; Structure-Activity Relationship; Testosterone | 2012 |
Other Studies
676 other study(ies) available for honokiol and lignans
| Article | Year |
|---|---|
[Determination of magnolol and honokiol in different processed samples of houpo by HPLC method].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hot Temperature; Lignans; Technology, Pharmaceutical | 1992 |
[Determination of magnolol and honokiol in 3 species of houpo (corter Magnoliae) of different ages by HPLC].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans; Plants, Medicinal; Quality Control; Species Specificity; Time Factors | 1992 |
[Quality standard of kaixiong shunqi pills].
Topics: Biphenyl Compounds; Chromatography, Thin Layer; Densitometry; Drug Combinations; Drugs, Chinese Herbal; Lignans; Quality Control | 1991 |
[Pharmacognostical studies on flos Houpo produced in Yunnan Province].
Topics: Biphenyl Compounds; Lignans; Oils, Volatile; Pharmacognosy; Plants, Medicinal; Trees | 1990 |
[Studies on the medicinal plants of Magnoliaceae tu-hou-po of Manglietia].
Topics: Biphenyl Compounds; Drugs, Chinese Herbal; Isoquinolines; Lignans; Neuromuscular Nondepolarizing Agents; Plants, Medicinal | 1989 |
[A study of the quality of Fujian native Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils].
Topics: Biphenyl Compounds; Lignans; Plants, Medicinal; Quality Control; Time Factors | 1989 |
Multiple effects of honokiol on catecholamine secretion from adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Barium; Biphenyl Compounds; Calcium; Carbachol; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Digitonin; Dimethylphenylpiperazinium Iodide; Exocytosis; Lignans; Potassium; Receptors, Cholinergic; Trifluoperazine | 1989 |
[Determination of magnolod and honokiol in different parts of Magnolia officinalis and the effect of processing on their content].
Topics: Biphenyl Compounds; Hot Temperature; Lignans; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plants, Medicinal; Tissue Distribution | 1985 |
Two antiplatelet agents from Magnolia officinalis.
Topics: Animals; Biphenyl Compounds; Calcium; In Vitro Techniques; Lignans; Medicine, Chinese Traditional; Platelet Aggregation Inhibitors; Platelet Function Tests; Rabbits; Thromboxane B2 | 1988 |
[Screening test for calcium antagonists in natural products. The active principles of Magnolia obovata].
Topics: Animals; Aorta, Thoracic; Biphenyl Compounds; Calcium Channel Blockers; In Vitro Techniques; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Muscle Contraction; Muscle, Smooth, Vascular; Plants, Medicinal; Rats; Rats, Inbred Strains | 1986 |
[Studies on the medicinal plants of Magnoliaceae. II. Botanical origins and resource utilization of a Chinese drug "hou pu"].
Topics: Biphenyl Compounds; China; Lignans; Plants, Medicinal | 1984 |
Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects.
Topics: Animals; Biphenyl Compounds; Central Nervous System Depressants; Chickens; Lignans; Male; Mice; Rats; Rats, Inbred Strains | 1983 |
Chemostructural requirement for centrally acting muscle relaxant effect of magnolol and honokiol, neolignane derivatives.
Topics: Animals; Biphenyl Compounds; Chemical Phenomena; Chemistry; Chickens; Eugenol; Lignans; Male; Mephenesin; Mice; Muscle Contraction; Muscle Relaxants, Central; Reflex; Spinal Cord; Structure-Activity Relationship | 1983 |
[Quantitative analysis of magnolol and honokiol in the bark of Magnolia officinalis Rehd et Wils and Magnolia rostrata WW Smith].
Topics: Biphenyl Compounds; China; Lignans; Plants, Medicinal | 1982 |
Effects of honokiol and magnolol on acetylcholine release from rat hippocampal slices.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Central Nervous System Depressants; Hippocampus; In Vitro Techniques; Lignans; Rats; Rats, Sprague-Dawley | 1995 |
Glucuronidation of magnolol assessed using HPLC/fluorescence.
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucuronidase; Lignans; Male; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1995 |
A novel 11 beta-hydroxysteroid dehydrogenase inhibitor contained in saiboku-to, a herbal remedy for steroid-dependent bronchial asthma.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Antineoplastic Agents, Phytogenic; Asthma; Biphenyl Compounds; Chromatography, High Pressure Liquid; Cortisone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glucocorticoids; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hydrocortisone; Hydroxysteroid Dehydrogenases; Immunosuppressive Agents; Lignans; Liver; Male; Medicine, Kampo; Rats; Rats, Wistar | 1994 |
Pharmacokinetics of honokiol after intravenous administration in rats assessed using high-performance liquid chromatography.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Indicators and Reagents; Injections, Intravenous; Lignans; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 1994 |
Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.
Topics: Animals; Antioxidants; Biphenyl Compounds; Lignans; Lipid Peroxidation; Male; Malondialdehyde; Mitochondria, Heart; Oxygen Consumption; Phytotherapy; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Vitamin E | 1994 |
Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome.
Topics: Animals; Antiemetics; Anura; Biphenyl Compounds; Catechols; Fatty Alcohols; Female; Lignans; Male; Plants, Medicinal | 1994 |
Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex.
Topics: Acetyltransferases; Animals; Biphenyl Compounds; Humans; In Vitro Techniques; Lignans; Male; Plant Extracts; Rats; Rats, Wistar; Reproducibility of Results | 1994 |
[A simultaneous determination of honokiol and mangolol in Oriental pharmaceutical decoctions containing magnolia bark by ion-pair high-performance liquid chromatography. II].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans | 1993 |
[A simultaneous determination of honokiol and magnolol in oriental pharmaceutical decoctions containing magnolia bark by ion-pair high-performance liquid chromatography].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans | 1993 |
[Quantitative determination of magnolol and honokiol in baoji pill by HPLC].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Gastrointestinal Agents; Lignans; Quality Control | 1995 |
Inhibition of leukotriene synthesis by honokiol in rat basophilic leukemia cells.
Topics: Animals; Anti-Allergic Agents; Biphenyl Compounds; Leukemia, Basophilic, Acute; Leukotriene Antagonists; Leukotrienes; Lignans; Rats; Tumor Cells, Cultured | 1996 |
Myocardial protective effect of honokiol: an active component in Magnolia officinalis.
Topics: Animals; Anti-Arrhythmia Agents; Biphenyl Compounds; Drugs, Chinese Herbal; Heart; Lignans; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley | 1996 |
Antiperoxidative activity of neolignans from Magnolia obovata.
Topics: Animals; Antioxidants; Biphenyl Compounds; Drugs, Chinese Herbal; Erythrocytes; Hemolysis; Lignans; Lipid Peroxidation; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Wistar; Trees | 1997 |
In vitro and in vivo protective effect of honokiol on rat liver from peroxidative injury.
Topics: Animals; Biphenyl Compounds; Gastrointestinal Agents; Lignans; Lipid Peroxidation; Liver; Liver Diseases; Male; Malondialdehyde; Mitochondria, Liver; Oxidation-Reduction; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vitamin E | 1997 |
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Biphenyl Compounds; Drugs, Chinese Herbal; Lignans; Male; Medicine, Kampo; Mice; Mice, Inbred Strains; Plant Extracts | 1998 |
Antimicrobial activity of magnolol and honokiol against periodontopathic microorganisms.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Biphenyl Compounds; Capnocytophaga; Cells, Cultured; Epithelial Cells; Fibroblasts; Gingiva; Humans; Lignans; Porphyromonas gingivalis; Prevotella; Veillonella | 1998 |
Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Bicuculline; Biphenyl Compounds; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Injections, Subcutaneous; Lignans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Tetragastrin; Therapeutic Equivalency | 1998 |
Honokiol induces apoptosis in human lymphoid leukemia Molt 4B cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Division; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Lignans; Tumor Cells, Cultured | 1998 |
Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Biphenyl Compounds; Diazepam; Hexobarbital; Learning; Lignans; Male; Memory; Mice; Mice, Inbred BALB C; Sleep; Substance-Related Disorders | 1999 |
Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: influence of L-NAME and aspirin.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Biphenyl Compounds; Blood Pressure; Coronary Disease; Enzyme Inhibitors; Lignans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1999 |
Application of the elevated plus-maze test in mice for evaluation of the content of honokiol in water extracts of magnolia.
Topics: Animals; Biphenyl Compounds; Lignans; Male; Maze Learning; Mice; Plant Extracts; Plants, Medicinal; Water | 1999 |
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium | 1999 |
Antifungal activity of magnolol and honokiol.
Topics: Antifungal Agents; Biphenyl Compounds; Humans; Lignans; Microbial Sensitivity Tests | 2000 |
Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Glands; Animals; Biphenyl Compounds; Calcium; Camphanes; Catecholamines; Cattle; Chromaffin Cells; In Vitro Techniques; Lignans; Magnoliopsida; Plant Extracts; Potassium; Sesquiterpenes, Eudesmane; Sodium; Terpenes | 2000 |
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Cell Line; Enzyme Inhibitors; Lignans; Lipopolysaccharides; Macrophage Activation; Macrophages; Magnetic Resonance Spectroscopy; Magnoliopsida; Mice; Nitric Oxide; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha | 2000 |
Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Drugs, Chinese Herbal; Hippocampus; Lignans; Male; Rats; Rats, Sprague-Dawley | 2000 |
Comparative assessment of the anxiolytic-like activities of honokiol and derivatives.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Biphenyl Compounds; Diazepam; Drug Evaluation, Preclinical; Drug Therapy, Combination; Lignans; Male; Mice | 2000 |
The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Lignans; Male; Maze Learning; Mice; Plant Extracts | 2000 |
Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis.
Topics: Actinobacillus; Anti-Bacterial Agents; Bacillus; Bacteria; Biphenyl Compounds; Drugs, Chinese Herbal; Humans; Lignans; Magnoliopsida; Microbial Sensitivity Tests; Micrococcus; Periodontal Diseases; Plants, Medicinal; Porphyromonas; Prevotella | 2001 |
Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro.
Topics: Animals; Biphenyl Compounds; Cell Line; Cerebellum; Drugs, Chinese Herbal; Flunitrazepam; GABA Agonists; GABA Modulators; Hippocampus; Humans; Insecta; Lignans; Male; Muscimol; Nitric Oxide Synthase; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Recombinant Proteins; Tritium | 2001 |
[Quality control for huoxiang-zhengqi liquid].
Topics: Asteraceae; Biphenyl Compounds; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Citrus; Drug Combinations; Drugs, Chinese Herbal; Lignans; Magnoliopsida; Quality Control | 1998 |
Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Fibrosarcoma; Humans; Lignans; Magnoliaceae; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Phytotherapy; Plant Bark; Tumor Cells, Cultured | 2001 |
Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats.
Topics: Animals; Biphenyl Compounds; Drugs, Chinese Herbal; Histamine H1 Antagonists; Histamine Release; Lignans; Magnoliaceae; Mast Cells; Medicine, Kampo; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Plant Bark; Plant Extracts; Rats | 2001 |
Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Lignans; Neurites; Neurons; Rats | 2002 |
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Biphenyl Compounds; Caspases; Cytochrome c Group; Enzyme Activation; Humans; Lignans; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
[Study on HPLC-FPS of cortex magnoliae officinalis].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans; Magnoliaceae; Quality Control | 2002 |
[A study on bark quality of Magnolia officinalis Rehd. et Wils].
Topics: Biphenyl Compounds; Lignans; Magnolia; Plant Bark; Plants, Medicinal; Quality Control | 2000 |
[Simultaneous determination of magnolol and honokiol in serum and urine by high performance liquid chromatography].
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans; Magnolia; Male; Platelet Aggregation Inhibitors; Rats; Rats, Wistar | 2000 |
Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Galactosamine; Hepatocytes; Lignans; Liver; Male; Protective Agents; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide | 2003 |
[Study on the relationship between provenance, leaf type and quality in Magnolia officinalis].
Topics: Biphenyl Compounds; China; Chromatography, High Pressure Liquid; Lignans; Magnolia; Plant Leaves; Plants, Medicinal; Quality Control; Species Specificity | 1998 |
[A study on the relationship between tree age and bark quality in Magnolia officinalis].
Topics: Age Factors; Biphenyl Compounds; China; Chromatography, High Pressure Liquid; Lignans; Magnolia; Plant Bark; Plant Leaves; Plants, Medicinal | 1999 |
[Study on genuineness of traditional Chinese medicine cortex Magnoliae officinalis].
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans; Magnolia; Plant Leaves; Plants, Medicinal; Quality Control | 2000 |
[Quality evaluation and utilization of germplasm resources of Magnolia officinalis].
Topics: Biphenyl Compounds; China; Drugs, Chinese Herbal; Ecosystem; Lignans; Magnolia; Phenols; Plant Bark; Plants, Medicinal; Quality Control; Seeds; Species Specificity | 2002 |
Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Biphenyl Compounds; Brain Ischemia; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Lignans; Magnolia; Male; Phytotherapy; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Long-Evans | 2003 |
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Biphenyl Compounds; Cell Division; Cell Line; Cell Line, Transformed; Endothelium, Vascular; Hemangiosarcoma; Humans; Lignans; Magnolia; MAP Kinase Signaling System; Mice; Mice, Nude; Phytotherapy; Plant Extracts; Transplantation, Heterologous | 2003 |
Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea.
Topics: Animals; Asthma; Biphenyl Compounds; Bronchodilator Agents; Calcium; Carbachol; Dose-Response Relationship, Drug; Lignans; Magnolia; Male; Muscle Contraction; Muscle, Smooth; Phytotherapy; Potassium Chloride; Swine; Trachea; Verapamil | 2003 |
Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells.
Topics: Animals; Biphenyl Compounds; Calcium; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Female; Humans; Lignans; Neuroblastoma; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley | 2003 |
The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Lignans; Male; Neutrophils; Rats; Rats, Long-Evans; Reactive Oxygen Species | 2003 |
The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus.
Topics: Animals; Biphenyl Compounds; Calcium; Carbachol; Central Nervous System Depressants; Dinoprost; Female; Fluorescent Dyes; Fura-2; In Vitro Techniques; Lignans; Muscarinic Agonists; Myometrium; Oxytocics; Oxytocin; Potassium Chloride; Rats; Uterine Contraction; Uterus | 2003 |
Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production.
Topics: Animals; Biphenyl Compounds; Brain Ischemia; Calcium; Calcium Signaling; Cell Adhesion; Cerebral Infarction; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Lignans; Lipid Peroxidation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neuroprotective Agents; Neutrophils; Rats; Rats, Long-Evans; Reactive Oxygen Species; Reperfusion Injury; Tetradecanoylphorbol Acetate | 2003 |
[Pharmacokinetics of honokiol in rats].
Topics: Animals; Biphenyl Compounds; Drugs, Chinese Herbal; Lignans; Rats; Rats, Sprague-Dawley | 2004 |
Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cerebral Cortex; Fetus; Lignans; Nerve Growth Factors; Neurites; Neurodegenerative Diseases; Neurons; Rats; Structure-Activity Relationship | 2004 |
Isolation and purification of honokiol and magnolol from cortex Magnoliae officinalis by high-speed counter-current chromatography.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Lignans; Magnetic Resonance Spectroscopy; Magnolia | 2004 |
Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Colorectal Neoplasms; Humans; Lignans; Tumor Suppressor Protein p53 | 2004 |
In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.
Topics: Adult; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Line; Dose-Response Relationship, Drug; Female; Humans; Lignans; Microbial Sensitivity Tests; Propionibacterium; Skin Irritancy Tests | 2004 |
Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Calcitriol; Calcium Channel Agonists; CD11b Antigen; Cell Differentiation; G1 Phase; HL-60 Cells; Humans; Lignans; Lipopolysaccharide Receptors; MAP Kinase Signaling System; Resting Phase, Cell Cycle; Tretinoin | 2005 |
Effects of Magnolol and Honokiol on the activities of streptococcal glucosyltransferases both in solution and adsorbed on an experimental pellicle.
Topics: Adsorption; Biphenyl Compounds; Enzyme Inhibitors; Glucans; Glucosyltransferases; Lignans; Microspheres; Streptococcus | 2004 |
Honokiol: a potent chemotherapy candidate for human colorectal carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Division; Cell Line, Tumor; Colorectal Neoplasms; DNA Fragmentation; Drugs, Chinese Herbal; Humans; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays | 2004 |
Cytotoxic neolignans: an SAR study.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Humans; Lignans; Structure-Activity Relationship | 2005 |
Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Caspases; Cytochromes c; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Flow Cytometry; Hepatocytes; Lignans; Magnolia; Male; Phytotherapy; Rats; Rats, Sprague-Dawley | 2005 |
Determination of honokiol and magnolol by micro HPLC with electrochemical detection and its application to the distribution analysis in branches and leaves of Magnolia obovata.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Electrochemistry; Lignans; Magnolia; Medicine, Kampo; Microfluidics; Plant Components, Aerial; Plant Extracts; Plant Leaves | 2005 |
The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Caspases; Chlorambucil; Cladribine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; In Vitro Techniques; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Lignans; Magnolia; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Vidarabine | 2005 |
Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biphenyl Compounds; Cytokines; Humans; Interleukin-8; Lignans; Magnolia; MAP Kinase Kinase Kinase 1; Microbial Sensitivity Tests; Monocytes; NF-kappa B; Phytotherapy; Picrates; Plant Extracts; Propionibacterium acnes; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2005 |
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Bone Marrow Cells; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Endothelial Cells; Humans; Insulin-Like Growth Factor I; Interleukin-6; Lignans; Multiple Myeloma; Neovascularization, Pathologic; Stromal Cells; Structure-Activity Relationship | 2005 |
Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Calcium; Cells, Cultured; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ion Channels; Lignans; Mice; N-Methylaspartate; Neurons; Platelet Aggregation Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Sodium | 2005 |
Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).
Topics: Animals; Benzylamines; Biphenyl Compounds; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Chromones; Diglycerides; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Female; Fetus; Flavonoids; Inositol 1,4,5-Trisphosphate; Lignans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Morpholines; Neurites; Neurons; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pregnancy; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides | 2005 |
Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Drugs, Chinese Herbal; Female; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Motility; Guinea Pigs; Lignans; Male; Mice; Muscle, Smooth; Rats | 2005 |
Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Biphenyl Compounds; Carotid Artery Thrombosis; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Epoprostenol; Fibrinolytic Agents; Lignans; Magnolia; Male; Nitric Oxide; Plants, Medicinal; Platelet Aggregation; Rabbits; Rats; Rats, Sprague-Dawley | 2005 |
[Studies on HPLC chromatogram of phenolic constituents of Cortex Magnoliae Officinalis].
Topics: Biphenyl Compounds; China; Chromatography, High Pressure Liquid; Ecosystem; Lignans; Magnolia; Plant Bark; Plants, Medicinal; Quality Control | 2005 |
Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Gene Expression; Genes, Reporter; Humans; I-kappa B Kinase; Lignans; Lipopolysaccharides; Luciferases; Lymphotoxin-alpha; NF-kappa B; NF-kappa B p50 Subunit; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2005 |
Honokiol protects against carbon tetrachloride induced liver damage in the rat.
Topics: Animals; Bilirubin; Biphenyl Compounds; Carbon Tetrachloride; Hepatic Veno-Occlusive Disease; Lignans; Liver; Liver Cirrhosis, Experimental; Magnolia; Male; Microscopy, Confocal; Rats; Rats, Long-Evans | 2005 |
Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia.
Topics: Adult; Biphenyl Compounds; Catechols; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Dyspepsia; Fatty Alcohols; Female; Gastric Emptying; Humans; Lignans; Male; Medicine, Kampo; Middle Aged; Phytotherapy; Statistics, Nonparametric; Ultrasonography | 2005 |
Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Drugs, Chinese Herbal; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lignans; Magnolia; Rhodamine 123; RNA, Messenger; Time Factors | 2006 |
Separation and determination of honokiol and magnolol in herbal medicines by flow injection-capillary electrophoresis.
Topics: Biphenyl Compounds; Buffers; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Electrophoresis, Capillary; Equipment Design; Herbal Medicine; Hydrogen-Ion Concentration; Lignans; Magnolia; Models, Chemical; Phosphates; Plant Extracts; Regression Analysis; Time Factors | 2006 |
A comparative study of upright counter-current chromatography and high-performance liquid chromatograpohy for preparative isolation and purification ofphenolic compounds from Magnoliae officinalis.
Topics: Biphenyl Compounds; Chromatography; Lignans; Magnetic Resonance Spectroscopy; Magnolia; Molecular Structure; Solvents | 2006 |
Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells.
Topics: Antioxidants; Apoptosis; Biphenyl Compounds; Calcium; Caspase 3; Caspases; Cell Adhesion; Cell Line; Cytochromes c; E-Selectin; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Lignans; Lipoproteins, LDL; Membrane Potentials; Mitochondria; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Vascular Cell Adhesion Molecule-1 | 2006 |
Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Lignans; Magnolia; Mass Spectrometry; Molecular Structure; Plant Bark; Reproducibility of Results | 2006 |
Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hydrogen Peroxide; L-Lactate Dehydrogenase; Lignans; Mitochondria; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin E | 2006 |
Determination of honokiol and magnolol in cortex Magnoliae Officinalis by capillary electrophoresis with electrochemical detection.
Topics: Anti-Arrhythmia Agents; Biphenyl Compounds; Drugs, Chinese Herbal; Electrochemistry; Electrodes; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Lignans; Magnolia; Plant Bark; Regression Analysis | 2006 |
Facile purification of honokiol and its antiviral and cytotoxic properties.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biphenyl Compounds; Cell Line, Tumor; Chlorocebus aethiops; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lignans; Vero Cells | 2006 |
Honokiol reduces oxidative stress, c-jun-NH2-terminal kinase phosphorylation and protects against glycochenodeoxycholic acid-induced apoptosis in primary cultured rat hepatocytes.
Topics: Animals; Apoptosis; Biphenyl Compounds; Caspases; Cells, Cultured; Glycochenodeoxycholic Acid; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Lignans; Magnolia; Oxidative Stress; Phosphorylation; Plant Bark; Poly(ADP-ribose) Polymerases; Rats | 2006 |
Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis.
Topics: Animals; Apoptosis; Biphenyl Compounds; Cell Proliferation; Chemokine CCL2; Disease Models, Animal; Extracellular Matrix Proteins; Gastrointestinal Agents; Glomerulonephritis, Membranoproliferative; Intercellular Adhesion Molecule-1; Lignans; Male; Proliferating Cell Nuclear Antigen; Proteinuria; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thy-1 Antigens | 2006 |
Carbon nanotube/poly(methyl methacrylate) composite electrode for capillary electrophoretic measurement of honokiol and magnolol in Cortex Magnoliae Officinalis.
Topics: Biphenyl Compounds; Catalysis; Drugs, Chinese Herbal; Electrodes; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Lignans; Magnolia; Nanotubes, Carbon; Polymethyl Methacrylate; Sensitivity and Specificity | 2006 |
Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells.
Topics: Antineoplastic Agents, Phytogenic; Atherosclerosis; Base Sequence; Biphenyl Compounds; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Humans; Imidazoles; Lignans; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinases; Pyridines; Sequence Deletion | 2006 |
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
Topics: Animals; Apoptosis; Biphenyl Compounds; Carrier Proteins; Cyclin D1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Synergism; Genes, myc; Humans; I-kappa B Proteins; Lignans; Matrix Metalloproteinase 9; Membrane Glycoproteins; Membrane Proteins; Mice; Molecular Structure; NF-kappa B; NF-KappaB Inhibitor alpha; Osteoclasts; Osteogenesis; Phosphorylation; Promoter Regions, Genetic; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Synaptotagmin I; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2006 |
Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Furocoumarins; Glucosides; Hesperidin; Lignans; Reproducibility of Results; Solutions; Thymol | 2006 |
Honokiol up-regulates prostacyclin synthease protein expression and inhibits endothelial cell apoptosis.
Topics: Animals; Apoptosis; Biphenyl Compounds; Caspase 3; Cells, Cultured; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Endothelial Cells; Epoprostenol; Fibrinolytic Agents; Gene Expression Regulation, Enzymologic; Indomethacin; Intramolecular Oxidoreductases; Lignans; Male; Rats; Rats, Sprague-Dawley; Tranylcypromine; Up-Regulation | 2007 |
Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Lignans; Pilot Projects | 2007 |
Analysis of magnolol and honokiol in biological fluids by capillary zone electrophoresis.
Topics: Animals; Biphenyl Compounds; Electrophoresis, Capillary; Fluorescence; Humans; Lignans; Microsomes, Liver; Rats; Reference Standards; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Blotting, Western; Bone Marrow Cells; Bone Neoplasms; Caspases; Cell Proliferation; Docetaxel; Drugs, Chinese Herbal; Flow Cytometry; Humans; Immunoenzyme Techniques; Lignans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostate-Specific Antigen; Prostatic Neoplasms; Radiography; Taxoids; Tumor Cells, Cultured | 2007 |
[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
Topics: Biphenyl Compounds; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Citric Acid; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Lignans; Pinellia; Plants, Medicinal; Polyethylene Glycols; Sodium Bicarbonate; Tablets; Technology, Pharmaceutical | 2006 |
[Investigate into of effective constituent transference of herba Ephedrae and cortex Magnoliae officinalis in preparation course of Shujin Kechuan capsule].
Topics: Asthma; Biphenyl Compounds; Capsules; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Ephedra sinica; Ephedrine; Lignans; Magnolia; Plant Structures; Plants, Medicinal; Technology, Pharmaceutical | 2006 |
Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Brain; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Lignans; Magnolia; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Phytotherapy; Plant Bark; Plant Extracts | 2007 |
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Doxorubicin; Drug Synergism; Female; Humans; Hydroxamic Acids; In Vitro Techniques; Lignans; Mice; Mice, Nude; Paclitaxel; Tamoxifen; Vorinostat | 2007 |
Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Apoptosis Inducing Factor; Biphenyl Compounds; Cell Death; Cell Line, Tumor; Cell Nucleus; Cyclophilins; Female; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Lignans; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Neoplasms; Reactive Oxygen Species | 2007 |
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
Topics: Antineoplastic Agents; Antiviral Agents; Biphenyl Compounds; HIV-1; Lignans; Molecular Structure | 2007 |
[Effects of the active compounds of M. officinalis on cariogenic bacteria].
Topics: Acids; Bacteria; Biofilms; Biphenyl Compounds; Dental Caries; Lignans; Magnolia; Plant Extracts | 2007 |
Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis.
Topics: Animals; Anti-Allergic Agents; Arthritis, Experimental; B-Lymphocytes; Biphenyl Compounds; CD40 Antigens; Cell Line; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation; Lignans; Magnolia; Mice; Mice, Transgenic; NF-kappa B; Phytotherapy; Plant Preparations; TNF Receptor-Associated Factor 2; Transcription Factor AP-1 | 2007 |
Honokiol, a neuroprotectant against mouse cerebral ischaemia, mediated by preserving Na+, K+-ATPase activity and mitochondrial functions.
Topics: Animals; Anti-Anxiety Agents; Biphenyl Compounds; Brain Ischemia; Lignans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred ICR; Neuroprotective Agents; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2007 |
Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Bone Marrow Cells; Chromatography, High Pressure Liquid; Cyclophosphamide; Dose-Response Relationship, Drug; Escherichia coli; Female; Lignans; Magnolia; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutation; Plant Bark; Plant Extracts; Reproducibility of Results; Salmonella typhimurium | 2007 |
Effects of honokiol and magnolol on acute and inflammatory pain models in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Central Nervous System Depressants; Disease Models, Animal; Drug Evaluation, Preclinical; Fixatives; Formaldehyde; Inflammation; Lignans; Lumbosacral Region; Magnolia; Memory; Mice; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos | 2007 |
Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cisplatin; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Hemangiosarcoma; In Vitro Techniques; Lignans; Mice; Mice, Nude; Mutagenesis; Neoplasm Transplantation; Neovascularization, Pathologic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine | 2008 |
Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Biphenyl Compounds; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; E2F1 Transcription Factor; G1 Phase; Humans; Immunoprecipitation; Lignans; Luciferases; Male; Phosphorylation; Prostatic Neoplasms; Reactive Oxygen Species; Resting Phase, Cell Cycle; Retinoblastoma Protein; RNA, Small Interfering; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Calpain; Cell Line, Tumor; Endoplasmic Reticulum Chaperone BiP; Glucose; Humans; Kinetics; Lignans; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Models, Biological; Stomach Neoplasms | 2007 |
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors.
Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Biphenyl Compounds; Cell Line, Tumor; Dose-Response Relationship, Drug; Immunoglobulin E; Inhibitory Concentration 50; Lignans; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Molecular Structure; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Pruritus; Rats | 2007 |
Preparative purification of anti-tumor derivatives of honokiol by high-speed counter-current chromatography.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2008 |
Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biphenyl Compounds; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Exploratory Behavior; Hindlimb Suspension; Hydroxyindoleacetic Acid; Lignans; Magnolia; Male; Mice; Mice, Inbred ICR; Phytotherapy; Rats; Rats, Wistar; Serotonin; Stress, Physiological; Swimming | 2008 |
Differential proteomic analysis of HeLa cells treated with Honokiol using a quantitative proteomic strategy.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Proliferation; Cytotoxins; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lignans; Magnolia; Neoplasm Proteins; Proteome; Proteomics; Time Factors | 2008 |
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Topics: Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line; Cell Proliferation; Dinoprostone; Fibronectins; Humans; Lignans; Lipopolysaccharides; Lymphocytes; Mitogens; Nitric Oxide; Oncogene Protein v-akt; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2008 |
Preparation and characterization of honokiol nanoparticles.
Topics: Biphenyl Compounds; Chemistry, Pharmaceutical; Crystallization; Drugs, Chinese Herbal; Emulsions; Lignans; Macromolecular Substances; Materials Testing; Molecular Conformation; Nanomedicine; Nanostructures; Particle Size; Solvents | 2008 |
Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Biphenyl Compounds; Cell Line, Tumor; Humans; Immunoblotting; Lignans; Magnolia; Male; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2008 |
Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Immunohistochemistry; Lignans; Liposomes; Mice; Mice, Nude; Ovarian Neoplasms | 2008 |
Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction.
Topics: Administration, Oral; Animals; Anthraquinones; Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Emodin; Female; Lignans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2008 |
Enhanced effects of xanthohumol plus honokiol on apoptosis in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Caspase 3; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Lignans; Mice; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Propiophenones; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction | 2008 |
Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis.
Topics: Apoptosis; Biphenyl Compounds; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Glucose; Humans; Lignans; NADPH Oxidases; NF-kappa B; Oxidative Stress; Phosphorylation; rac1 GTP-Binding Protein; Reactive Oxygen Species; Signal Transduction; Umbilical Veins | 2008 |
Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Lignans; Mice; Mice, Nude; Neovascularization, Pathologic; Ovarian Neoplasms | 2008 |
A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel.
Topics: Animals; Biphenyl Compounds; Delayed-Action Preparations; Drug Delivery Systems; Emulsions; Excipients; Hydrogels; Hydrophobic and Hydrophilic Interactions; Injections, Subcutaneous; Lignans; Mice; Nanoparticles; Poloxamer; Polyesters; Polyethylene Glycols; Solvents; Temperature | 2008 |
Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Ileum; Lignans; Magnolia; Molecular Structure; Muscle Contraction; Muscle, Smooth; Plant Extracts | 2008 |
Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2).
Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Imidazoles; Lignans; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tetrazolium Salts; Thiazoles | 2008 |
Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Drugs, Chinese Herbal; Female; Lignans; Liposomes; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Xenograft Model Antitumor Assays | 2008 |
Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Lignans; Magnolia; Medicine, Chinese Traditional; Quinazolines; Signal Transduction; Sirolimus; Time Factors | 2008 |
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Enzyme Activation; Humans; Lignans; Mice; Models, Chemical; Neoplasm Transplantation; Neoplasms; Phospholipase D; ras Proteins; Signal Transduction | 2008 |
[Phenols in seedling cortex of Magnolia officinalis from Enshi].
Topics: Age Factors; Biphenyl Compounds; China; Chromatography, High Pressure Liquid; Lignans; Magnolia; Plant Bark; Plant Stems; Plants, Medicinal; Seedlings | 2008 |
[Pharmacokinetics of honokiol in rat after oral administration of Cortex of Magnolia officinalis and its compound preparation Houpu Sanwu Decoction].
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Biphenyl Compounds; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Lignans; Magnolia; Male; Rats; Rats, Wistar | 2008 |
Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Humans; Kinetics; Lignans; Peroxides; Spin Labels; Superoxides | 2008 |
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
Topics: Apoptosis; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Humans; JNK Mitogen-Activated Protein Kinases; Lignans; Lung Neoplasms; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Receptors, Death Domain; TNF-Related Apoptosis-Inducing Ligand; Ubiquitin | 2008 |
Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cisplatin; Humans; In Situ Nick-End Labeling; Lignans; Liposomes; Lung Neoplasms; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Plant Extracts; Platelet Endothelial Cell Adhesion Molecule-1 | 2008 |
Mechanisms underlying the honokiol inhibition of evoked glutamate release from glutamatergic nerve terminals of the rat cerebral cortex.
Topics: Animals; Biphenyl Compounds; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Lignans; Male; Neural Inhibition; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptosomes | 2008 |
[Effects of honokiol on proliferation and apoptosis of human cervical carcinoma cell line Hela in vitro].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flow Cytometry; HeLa Cells; Humans; Lignans; Time Factors | 2008 |
Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.
Topics: Acetophenones; Benzoates; Biphenyl Compounds; Bridged-Ring Compounds; Coumaric Acids; Drugs, Chinese Herbal; Flavanones; Glucosides; Glycyrrhizic Acid; Hesperidin; Iridoids; Isoflavones; Lignans; Medicine, Chinese Traditional; Molecular Structure; Monoterpenes; Quality Control; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2008 |
Self-assembled honokiol-loaded micelles based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymer.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Humans; Lasers; Lignans; Lung Neoplasms; Micelles; Microscopy, Atomic Force; Particle Size; Polyesters; Polyethylene Glycols; Temperature | 2009 |
[Effects of storage time on magnolol and honokiol contents in bark of Magnolia officinalis].
Topics: Biphenyl Compounds; Drug Storage; Drugs, Chinese Herbal; Lignans; Magnolia; Plant Bark; Time Factors | 2008 |
Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Biphenyl Compounds; Carcinoma, Lewis Lung; Cell Cycle; Cell Line, Tumor; Combined Modality Therapy; Humans; Lignans; Liposomes; Lung Neoplasms; Magnolia; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Radiation Tolerance; Transplantation, Heterologous | 2008 |
Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; Down-Regulation; ErbB Receptors; Female; Humans; Lignans; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Tumor Suppressor Proteins | 2009 |
Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol.
Topics: Adenocarcinoma; Base Sequence; Bile Acids and Salts; Biphenyl Compounds; Cell Line, Transformed; Cyclophilins; Epithelial Cells; Esophageal Neoplasms; Esophagus; Humans; Lignans; Oxidation-Reduction; Peptidyl-Prolyl Isomerase F; RNA, Small Interfering | 2009 |
In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) copolymer.
Topics: Biocompatible Materials; Biphenyl Compounds; Cell Line; Cell Survival; Drug Delivery Systems; Humans; Hydrogels; Lignans; Poloxamer; Polyesters; Polyethylene Glycols; Temperature; Vitamin B 12 | 2009 |
Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Lewis Lung; Cell Line; Endothelial Cells; Female; Humans; Lignans; Liposomes; Lymphangiogenesis; Lymphatic Metastasis; Mice; Mice, Inbred C57BL; Vascular Endothelial Growth Factor D; Vascular Endothelial Growth Factor Receptor-3; Xenograft Model Antitumor Assays | 2009 |
Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi.
Topics: Allyl Compounds; Antifungal Agents; Biphenyl Compounds; Chromatography, Thin Layer; Fungi; Lignans; Magnolia; Microbial Sensitivity Tests; Mycelium; Phenyl Ethers; Plant Bark; Plant Diseases; Plant Extracts | 2009 |
Antineoplastic effects of Magnoliae officinalis in tumours other than hepatomas.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Humans; Lignans; Magnolia; Neoplasms; Plant Extracts | 2009 |
Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation.
Topics: Animals; Biphenyl Compounds; Chemokine CCL2; Creatinine; Cyclooxygenase 2; Dose-Response Relationship, Drug; Gene Expression; Inflammation; Interleukin-1beta; Interleukin-6; Lignans; Lipid Peroxidation; Male; Muscle, Skeletal; Oxidative Stress; Physical Conditioning, Animal; Poly(ADP-ribose) Polymerases; Proteins; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes.
Topics: Active Transport, Cell Nucleus; Animals; Biphenyl Compounds; Cell Line, Tumor; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; fas Receptor; Fatty Acids; Fatty Liver, Alcoholic; Genes, Reporter; Glutathione; Lignans; Lipogenesis; Liver; Male; Promoter Regions, Genetic; Protective Agents; Rats; Rats, Wistar; Sterol Regulatory Element Binding Protein 1; Transcription, Genetic; Transfection; Triglycerides; Tumor Necrosis Factor-alpha | 2009 |
Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) nanoparticles for honokiol delivery in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line; Cell Line, Tumor; Drug Carriers; Drugs, Chinese Herbal; Erythrocytes; Female; Hemolysis; Humans; Lignans; Nanoparticles; Ovarian Neoplasms; Particle Size; Polyesters; Polyethylene Glycols; Rabbits; Solvents | 2009 |
Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery.
Topics: Administration, Inhalation; Administration, Intranasal; Biphenyl Compounds; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Stability; Excipients; Lignans; Lung; Mannitol; Nanoparticles; Powders; Respiratory Mucosa; Technology, Pharmaceutical | 2009 |
Polymeric matrix for drug delivery: honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel.
Topics: Animals; Biocompatible Materials; Biphenyl Compounds; Drug Delivery Systems; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrophobic and Hydrophilic Interactions; Lignans; Mice; Nanoparticles; Polyesters; Polyethylene Glycols; Temperature | 2010 |
Novel composite drug delivery system for honokiol delivery: self-assembled poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) micelles in thermosensitive poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel.
Topics: Animals; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Hydrogels; Lignans; Mice; Polyesters; Polyethylene Glycols; Temperature | 2009 |
Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Carcinoma, Lewis Lung; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Female; Genetic Therapy; Humans; In Situ Nick-End Labeling; Lignans; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide Synthase; Tumor Cells, Cultured | 2009 |
Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lignans; Structure-Activity Relationship | 2009 |
[Micronization of magnolia bark extract by RESS as well as dissolution and pharmacokinetics evaluation].
Topics: Administration, Oral; Animals; Area Under Curve; Biphenyl Compounds; Drug Compounding; Drugs, Chinese Herbal; Lignans; Magnolia; Male; Microspheres; Particle Size; Plant Bark; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Solubility | 2009 |
Production of honokiol and magnolol in suspension cultures of Magnolia dealbata Zucc.
Topics: Anti-Anxiety Agents; Antineoplastic Agents, Phytogenic; Biomass; Biphenyl Compounds; Carbohydrates; Cells, Cultured; Chromatography, High Pressure Liquid; Kinetics; Lignans; Magnolia; Mexico | 2009 |
Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Brain; Cholecystokinin; Depression; Drug Synergism; Drug Therapy, Combination; Gastric Mucosa; Gastrins; Lignans; Male; Oils, Volatile; Rats; Rats, Wistar; Serotonin; Swimming; Zingiber officinale | 2009 |
Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes.
Topics: Anti-Allergic Agents; Biphenyl Compounds; Carcinogens; Cells, Cultured; Humans; Interleukin-1beta; Lignans; Lipopolysaccharides; Macrophages; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2009 |
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
Topics: Analgesics; Animals; Anti-Infective Agents; Biphenyl Compounds; Dinoprostone; Excitatory Amino Acid Agents; Glycine; Immunohistochemistry; Inflammation; Lignans; Male; Mice; N-Methylaspartate; Phenylacetates; Proto-Oncogene Proteins c-fos; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2009 |
Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Bone Neoplasms; Calcium; Calpain; Cell Line, Tumor; Chondrosarcoma; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Lignans; Male; Mice; Mice, Inbred BALB C; Mitochondria; Xenograft Model Antitumor Assays | 2010 |
Honokiol nanoparticles in thermosensitive hydrogel: therapeutic effects on malignant pleural effusion.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Crystallization; Drug Carriers; Hydrogels; Lignans; Macromolecular Substances; Materials Testing; Mice; Mice, Inbred C57BL; Molecular Conformation; Nanomedicine; Nanoparticles; Particle Size; Pleural Effusion, Malignant; Radiography; Surface Properties; Temperature; Treatment Outcome | 2009 |
A novel composite drug delivery system: honokiol nanoparticles in thermosensitive hydrogel based on chitosan.
Topics: Biphenyl Compounds; Chitosan; Chromatography, High Pressure Liquid; Drug Delivery Systems; Hydrogels; Lignans; Microscopy, Atomic Force; Nanoparticles; Temperature | 2009 |
Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemistry, Pharmaceutical; Chromatography, Gel; Dose-Response Relationship, Drug; Drug Carriers; Female; Hemolysis; Humans; Kinetics; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Molecular Weight; Nanoparticles; Nanotechnology; Ovarian Neoplasms; Particle Size; Polyesters; Polyethylene Glycols; Solubility; Solvents; Surface Properties; Technology, Pharmaceutical | 2010 |
Micronization of magnolia bark extract with enhanced dissolution behavior by rapid expansion of supercritical solution.
Topics: Biphenyl Compounds; Calorimetry, Differential Scanning; Carbon Dioxide; Drugs, Chinese Herbal; Equipment Design; Lignans; Magnolia; Molecular Structure; Particle Size; Plant Bark; Solubility; Solutions; Spectrophotometry, Infrared; Technology, Pharmaceutical; Time Factors | 2010 |
Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; cdc42 GTP-Binding Protein; Cell Movement; Down-Regulation; Hep G2 Cells; Histocytochemistry; Humans; Isotope Labeling; Lignans; Mice; Mice, Nude; Proteome; Proteomics; rac1 GTP-Binding Protein; ras GTPase-Activating Proteins; Reproducibility of Results; Statistics, Nonparametric; Tumor Burden | 2010 |
A novel transdermal honokiol formulation based on Pluronic F127 copolymer.
Topics: Administration, Cutaneous; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Excipients; Hydrogels; Lignans; Micelles; Particle Size; Permeability; Poloxamer; Rats; Rats, Sprague-Dawley; Skin Absorption; Temperature | 2010 |
Effects of chronic treatment with honokiol in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Antioxidants; Aorta; Biphenyl Compounds; Blood Pressure; Elastin; Hypertension; Lignans; Liver; Magnolia; Malondialdehyde; Nitrates; Nitrites; Nitroprusside; Plant Extracts; Rats; Rats, Inbred SHR; Vasodilator Agents | 2010 |
Honokiol inhibits osteoclast differentiation and function in vitro.
Topics: Acid Phosphatase; Actins; Animals; Biphenyl Compounds; Bone Density Conservation Agents; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Dentin; Isoenzymes; Lignans; Magnolia; Mice; Mitogen-Activated Protein Kinases; NFATC Transcription Factors; Osteoclasts; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-fos; RANK Ligand; Tartrate-Resistant Acid Phosphatase | 2010 |
Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents.
Topics: Anti-Infective Agents; Antifungal Agents; Bacteria; Biphenyl Compounds; Escherichia coli; Fungi; Lignans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Solubility | 2010 |
Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line; Cells, Cultured; Down-Regulation; Humans; Lignans; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Protein Kinase C; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Honokiol and magnolol production by in vitro micropropagated plants of Magnolia dealbata, an endangered endemic Mexican species.
Topics: Biphenyl Compounds; Conservation of Natural Resources; Culture Media; Lignans; Magnolia; Mexico; Plant Roots; Plant Shoots; Tissue Culture Techniques | 2010 |
Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Biphenyl Compounds; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Drug Administration Schedule; Drug Synergism; Humans; Imatinib Mesylate; Leukemia; Lignans; Piperazines; Pyrimidines; Vacuoles | 2010 |
Purification of honokiol derivatives from one-pot synthesis by high-performance counter-current chromatography.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Lignans; Magnetic Resonance Spectroscopy | 2010 |
Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal; ErbB Receptors; Erlotinib Hydrochloride; Head and Neck Neoplasms; Humans; Lignans; Mice; Mice, Nude; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2010 |
Chemopreventive effects of honokiol on UVB-induced skin cancer development.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Caspases; Disease Models, Animal; Female; Lignans; Mice; Neoplasms, Radiation-Induced; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2010 |
Biodegradable self-assembled PEG-PCL-PEG micelles for hydrophobic honokiol delivery: I. Preparation and characterization.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Drug Screening Assays, Antitumor; Drug Stability; Drugs, Chinese Herbal; Humans; Lignans; Lung Neoplasms; Mice; Micelles; Microscopy, Electron, Transmission; Particle Size; Polyesters; Polyethylene Glycols; Solubility; Sonication; X-Ray Diffraction | 2010 |
Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.
Topics: Biphenyl Compounds; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Imidazoles; Ionic Liquids; Lignans; Magnolia; Molecular Structure; Solvents; Ultrasonics | 2010 |
Honokiol: an effective inhibitor of high-glucose-induced upregulation of inflammatory cytokine production in human renal mesangial cells.
Topics: Animals; Anti-Allergic Agents; Biphenyl Compounds; Cell Survival; Cells, Cultured; Cytokines; Glucose; Humans; Lignans; Mesangial Cells; Up-Regulation | 2010 |
Honokiol increases ABCA1 expression level by activating retinoid X receptor beta.
Topics: ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Base Sequence; Biphenyl Compounds; Blotting, Western; Cell Line, Tumor; DNA Primers; Humans; In Situ Nick-End Labeling; Ligands; Lignans; Promoter Regions, Genetic; Retinoid X Receptor beta | 2010 |
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Arachidonate 15-Lipoxygenase; Biphenyl Compounds; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lignans; Linoleic Acids; Male; Mice; Mice, Inbred BALB C; Mice, Nude; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Stomach Neoplasms; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Substituted dineolignans from Magnolia garrettii.
Topics: Austria; Biphenyl Compounds; Lignans; Magnolia; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenyl Ethers; Plant Leaves | 2010 |
The synergy of honokiol and fluconazole against clinical isolates of azole-resistant Candida albicans.
Topics: Animals; Antifungal Agents; Biphenyl Compounds; Candida albicans; Candidiasis; Colony Count, Microbial; Drug Resistance, Fungal; Drug Synergism; Fluconazole; Humans; Lignans; Mice; Microbial Sensitivity Tests; Microbial Viability; Treatment Outcome | 2010 |
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Bexarotene; Biphenyl Compounds; Cholesterol; Humans; Ligands; Lignans; Macrophages; Magnolia; Male; Mice; Mice, Inbred Strains; Molecular Structure; Plant Bark; Plants, Medicinal; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Tetrahydronaphthalenes | 2010 |
Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Ca(2+) Mg(2+)-ATPase; Calcium; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Flavonoids; Lignans; Linear Models; Male; Membrane Potential, Mitochondrial; Mice; Motor Activity; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phenols; Phytotherapy; Polyphenols; Psychomotor Performance; Reactive Oxygen Species; Rotarod Performance Test; Silver Staining; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2010 |
Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage.
Topics: Animals; Arthritis, Experimental; Biphenyl Compounds; Cattle; Cytokines; Disease Progression; Inflammation; Inflammation Mediators; Lignans; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred DBA; Oxidation-Reduction; Oxidative Stress | 2010 |
Separation of honokiol and magnolol by intermittent counter-current extraction.
Topics: Biphenyl Compounds; Chemical Fractionation; Countercurrent Distribution; Drugs, Chinese Herbal; Lignans; Models, Chemical | 2010 |
Distinct photoacidity of honokiol from magnolol.
Topics: Acids; Biphenyl Compounds; Hydrogen-Ion Concentration; Lignans; Magnetic Resonance Spectroscopy; Photochemistry; Spectrometry, Fluorescence | 2011 |
Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Biphenyl Compounds; Blotting, Western; Cell Cycle; Cell Transformation, Neoplastic; Cyclin-Dependent Kinases; Cyclooxygenase 2; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Immunoenzyme Techniques; Inflammation Mediators; Lignans; Magnolia; Mice; Mice, Hairless; Papilloma; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Ultraviolet Rays | 2010 |
Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Biphenyl Compounds; Calcium; Caspase 3; Cell Survival; Drugs, Chinese Herbal; Lignans; Magnolia; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species | 2010 |
Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Biphenyl Compounds; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Female; Fluorescent Antibody Technique; Hypersensitivity; Lignans; Lung; Mice; Mice, Inbred C57BL; Th2 Cells | 2010 |
Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways.
Topics: Apoptosis; Biphenyl Compounds; Caspase 3; Caspase 9; Cell Line; Down-Regulation; Enzyme Activation; Epithelial Cells; Humans; Hydrogen Peroxide; Lens, Crystalline; Lignans; Mitogen-Activated Protein Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Transcription Factor RelA; Up-Regulation | 2011 |
Synthesis, structural and in vitro studies of well-dispersed monomethoxy-poly(ethylene glycol)-honokiol conjugate micelles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Colloids; Diffusion; Dogs; Drug Compounding; Lignans; Materials Testing; Micelles; Nanocapsules; Particle Size; Plasma; Polyethylene Glycols | 2010 |
A novel drug and gene co-delivery system based on Poly(epsilon-caprolactone)-Poly(ethylene glycol)-Poly(epsilon-caprolactone) grafted polyethyleneimine micelle.
Topics: Biphenyl Compounds; Cell Survival; DNA; Drug Delivery Systems; Gene Transfer Techniques; HEK293 Cells; Humans; Lignans; Micelles; Nanoconjugates; Particle Size; Polyesters; Polyethylene Glycols; Polyethyleneimine; Temperature | 2010 |
Co-delivery honokiol and doxorubicin in MPEG-PLA nanoparticles.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Doxorubicin; Humans; Lactic Acid; Lignans; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers | 2010 |
Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells.
Topics: Anti-Inflammatory Agents; Biphenyl Compounds; Cell Survival; Cyclooxygenase 2; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Inflammation Mediators; Lignans; Lipopolysaccharides; Mesangial Cells; Nitric Oxide Synthase Type II; Phosphorylation; Signal Transduction | 2011 |
Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Cyclooxygenase 2; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Female; Humans; Lignans; Magnolia; Mice; Models, Biological; Molecular Targeted Therapy; Nitric Oxide; Phytotherapy | 2011 |
Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro.
Topics: Actins; Animals; Biphenyl Compounds; Cell Line; Chemokine CCL2; Connective Tissue Growth Factor; Extracellular Matrix Proteins; Fibrosis; Genes, Reporter; Intercellular Adhesion Molecule-1; Kidney; Kidney Tubules; Lignans; Luciferases; Male; Phosphorylation; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Ureteral Obstruction | 2011 |
Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation.
Topics: Acute Lung Injury; Animals; Anti-Infective Agents; Biphenyl Compounds; Endotoxemia; Inflammation; Lignans; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Sepsis | 2011 |
5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway.
Topics: Actins; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Embryo, Nonmammalian; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; Neovascularization, Physiologic; Signal Transduction; Umbilical Veins; Wound Healing; Zebrafish | 2011 |
Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biphenyl Compounds; Cell Differentiation; Immunoblotting; Insulin; Lignans; Magnetic Resonance Spectroscopy; Magnolia; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
Preparation, characterization, pharmacokinetics, and bioactivity of honokiol-in-hydroxypropyl-β-cyclodextrin-in-liposome.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Biphenyl Compounds; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Crystallization; Drug Carriers; Drug Compounding; Drug Stability; Hep G2 Cells; Humans; Injections, Intravenous; Lignans; Liposomes; Male; Microscopy, Electron, Transmission; Particle Size; Rats; Rats, Sprague-Dawley; Solubility; Surface Properties; X-Ray Diffraction | 2011 |
Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol.
Topics: Animals; Area Under Curve; Biphenyl Compounds; Blood Proteins; Female; Half-Life; Humans; Injections, Intravenous; Lignans; Liposomes; Male; Mice; Mice, Inbred BALB C; Particle Size; Polyethylene Glycols; Protein Binding; Solubility | 2011 |
In vitro metabolism and disposition of honokiol in rat and human livers.
Topics: Animals; Bile; Biotransformation; Biphenyl Compounds; Chromatography, High Pressure Liquid; Cytosol; Glucuronic Acid; Humans; In Vitro Techniques; Insecta; Lignans; Liver; Magnolia; Male; Metabolic Detoxication, Phase I; Microsomes, Liver; Perfusion; Rats; Rats, Wistar; Species Specificity; Sulfuric Acids; Tissue Distribution | 2011 |
Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drugs, Chinese Herbal; Flow Cytometry; Fluorouracil; Humans; In Situ Nick-End Labeling; Lignans; Magnolia; Mouth Neoplasms; Phytotherapy; Plant Extracts | 2011 |
Honokiol produces anti-neoplastic effects on melanoma cells in vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Blotting, Western; Caspases; Cell Proliferation; Cytochromes c; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Lignans; Melanoma; Tumor Cells, Cultured | 2011 |
Honokiol inhibits hypoxia-inducible factor-1 pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cobalt; Enzyme-Linked Immunosorbent Assay; Female; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Lignans; Luciferases; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms | 2011 |
Magnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathway.
Topics: 3T3 Cells; 4-Chloro-7-nitrobenzofurazan; Adipocytes; Adipogenesis; Animals; Biphenyl Compounds; Cell Survival; Deoxyglucose; Drug Synergism; Glucose; Humans; Hypoglycemic Agents; Insulin; Lignans; Lipid Metabolism; Magnolia; Mice; Plant Extracts; Signal Transduction | 2011 |
Honokiol: an effective inhibitor of tumor necrosis factor-α-induced up-regulation of inflammatory cytokine and chemokine production in human synovial fibroblasts.
Topics: Biphenyl Compounds; Blotting, Western; Cells, Cultured; Chemokines; Cytokines; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fluorescent Antibody Technique; Humans; Inflammation Mediators; Lignans; Synovial Membrane; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cerebrospinal Fluid; Chromatography, High Pressure Liquid; Female; Glioma; Gliosarcoma; Humans; Lignans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 2011 |
Effect of honokiol on activity of GAD(65) and GAD(67) in the cortex and hippocampus of mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Biphenyl Compounds; Central Nervous System Depressants; Cerebral Cortex; Diazepam; Glutamate Decarboxylase; Hippocampus; Humans; Lignans; Magnolia; Male; Maze Learning; Mice; Mice, Inbred ICR; Phytotherapy; Plant Bark; Plant Extracts | 2011 |
Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators.
Topics: Alkaline Phosphatase; Animals; Antimycin A; Biphenyl Compounds; Bone Resorption; Calcification, Physiologic; Cell Growth Processes; Cell Line; Collagen; Glutathione; Humans; Interleukin-6; Lignans; Magnolia; Mice; Osteoblasts; Osteoporosis; Osteoprotegerin; Phytotherapy; RANK Ligand; Tumor Necrosis Factor-alpha | 2011 |
Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells.
Topics: Biphenyl Compounds; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dendritic Cells; Endocytosis; Enzyme Activation; Humans; Inflammation; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phenotype; Th1 Cells; Th2 Cells | 2011 |
Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship.
Topics: Animals; Biphenyl Compounds; Lignans; Models, Molecular; Oocytes; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2011 |
Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA.
Topics: Antioxidants; Biphenyl Compounds; DNA; Free Radical Scavengers; Lignans | 2011 |
Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Biphenyl Compounds; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Screening Assays, Antitumor; Drug Synergism; G1 Phase; Gemcitabine; Humans; Lignans; NF-kappa B; Pancreatic Neoplasms; Protein Transport | 2011 |
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; CSK Tyrosine-Protein Kinase; G1 Phase; Genes, Reporter; Humans; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Lignans; Liver Neoplasms; Models, Biological; Poly(ADP-ribose) Polymerases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor | 2012 |
Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antioxidants; Biphenyl Compounds; Cell Survival; Cyclic AMP Response Element-Binding Protein; Lignans; Magnolia; Membrane Potential, Mitochondrial; Mice; Mitochondria; Osteoblasts; Oxidative Stress; Oxygen; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Superoxides | 2011 |
Honokiol attenuates vascular contraction through the inhibition of the RhoA/Rho-kinase signalling pathway in rat aortic rings.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Biphenyl Compounds; Dose-Response Relationship, Drug; Lignans; Magnolia; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Plant Extracts; Pyridones; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sodium Fluoride; Vasoconstriction; Vasodilator Agents | 2011 |
Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; DNA Mismatch Repair; HCT116 Cells; Humans; Lignans; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2011 |
[Study on transport characteristics of honokiol in Caco-2 cell model by HPLC].
Topics: Biological Transport; Biphenyl Compounds; Caco-2 Cells; Chromatography, High Pressure Liquid; Diffusion; Humans; Lignans; Permeability | 2011 |
Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship.
Topics: Allyl Compounds; Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Benzaldehydes; Biphenyl Compounds; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Endothelial Cells; Endothelium, Vascular; Humans; In Vitro Techniques; Lignans; Magnolia; Neovascularization, Pathologic; Neovascularization, Physiologic; Structure-Activity Relationship; Zebrafish | 2011 |
Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry.
Topics: Animals; Area Under Curve; Biphenyl Compounds; Chromatography, Liquid; Curcumin; Diarylheptanoids; Drug Delivery Systems; Drug Stability; Lignans; Linear Models; Lipids; Male; Mice; Mice, Inbred ICR; Nanoparticles; Neoplasm Transplantation; Neoplasms; Reproducibility of Results; Tandem Mass Spectrometry | 2011 |
Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Blotting, Western; Bone Morphogenetic Protein 2; Bone Resorption; Cell Differentiation; Cell Line; Drugs, Chinese Herbal; Humans; Lignans; Magnolia; Mice; NF-kappa B; Osteoclasts; Osteogenesis; Osteoporosis; Signal Transduction; Smad Proteins; Tumor Necrosis Factor-alpha | 2011 |
Honokiol, a chemopreventive agent against skin cancer, induces cell cycle arrest and apoptosis in human epidermoid A431 cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin D2; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; DNA Fragmentation; Gene Expression Regulation, Neoplastic; Humans; Lignans; Mice; Skin Neoplasms | 2011 |
Antimicrobial activity and cytotoxic effects of Magnolia dealbata and its active compounds.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Biphenyl Compounds; Fungi; Humans; Leukocytes, Mononuclear; Lignans; Magnolia; Plant Extracts | 2011 |
Antimetastatic activity of honokiol in osteosarcoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Bone Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Lignans; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred C3H; Osteosarcoma | 2012 |
Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes.
Topics: Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line; Drugs, Chinese Herbal; Flavonoids; Humans; Interleukin-8; Keratinocytes; Lignans; Propionibacterium acnes; Triterpenes; Ursolic Acid | 2012 |
The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Proliferation; Humans; Lignans; Neuroma, Acoustic; Tumor Cells, Cultured | 2012 |
Multiple effects of Honokiol on the life cycle of hepatitis C virus.
Topics: Antiviral Agents; Biphenyl Compounds; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Gene Expression Regulation, Viral; Genes, Reporter; Genotype; HEK293 Cells; Hepacivirus; Humans; Interferon-alpha; Lignans; Magnolia; Phenotype; Plants, Medicinal; Protein Biosynthesis; Transfection; Viral Proteins; Virus Internalization; Virus Replication | 2012 |
[Honokiol-induced apoptosis of human non-Hodgkin lymphoma Raji cells and its possible mechanism].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-Associated Death Protein; Biphenyl Compounds; Burkitt Lymphoma; Caspase 8; Cell Line, Tumor; Cell Proliferation; Humans; Lignans; Lymphoma, Non-Hodgkin | 2011 |
An expedient synthesis of honokiol and its analogues as potential neuropreventive agents.
Topics: Biphenyl Compounds; Catalysis; Cell Death; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Design; Humans; Lignans; Models, Chemical; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Time Factors | 2012 |
Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Humans; Immunohistochemistry; Lignans; Molecular Structure; Nerve Growth Factors; Neurites; Neurogenesis; Small Molecule Libraries; Structure-Activity Relationship | 2012 |
A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.
Topics: 3T3-L1 Cells; Animals; Anticarcinogenic Agents; Bexarotene; Biphenyl Compounds; Caco-2 Cells; Dimerization; Humans; Lignans; Liver X Receptors; Magnolia; Mice; Orphan Nuclear Receptors; Plant Extracts; PPAR gamma; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; RNA, Messenger; Rosiglitazone; Signal Transduction; Tetrahydronaphthalenes; Thiazolidinediones | 2012 |
Honokiol attenuates the severity of acute pancreatitis and associated lung injury via acceleration of acinar cell apoptosis.
Topics: Acinar Cells; Acute Disease; Acute Lung Injury; Amylases; Animals; Apoptosis; Biphenyl Compounds; Caspase 3; Disease Models, Animal; Endoplasmic Reticulum; Enzyme Inhibitors; HMGB1 Protein; Interleukin-1beta; Lignans; Lipase; Lung; Male; Mice; Mice, Inbred BALB C; Pancreas; Pancreatitis; Time Factors; Transcription Factor CHOP; Tumor Necrosis Factor-alpha | 2012 |
Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Blood-Brain Barrier; Brain Neoplasms; Caspases; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cytochromes c; DNA Fragmentation; Endothelial Cells; Humans; Lignans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred ICR; Mitochondria; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Tight Junctions | 2012 |
Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Brain Ischemia; Glucose Intolerance; Infarction, Middle Cerebral Artery; Insulin; Lignans; Male; Mice; Phosphoenolpyruvate Carboxykinase (ATP) | 2012 |
Honokiol attenuates torsion/detorsion-induced testicular injury in rat testis by way of suppressing endoplasmic reticulum stress-related apoptosis.
Topics: Animals; Apoptosis; Biphenyl Compounds; Drugs, Chinese Herbal; Endoplasmic Reticulum; Lignans; Male; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Spermatogenesis | 2012 |
Separation and determination of honokiol and magnolol in Chinese traditional medicines by capillary electrophoresis with the application of response surface methodology and radial basis function neural network.
Topics: Biphenyl Compounds; Computational Biology; Drugs, Chinese Herbal; Electrophoresis, Capillary; Lignans; Magnolia; Models, Statistical; Neural Networks, Computer; Plant Bark; Reproducibility of Results | 2012 |
Anti-HBV activities of Streblus asper and constituents of its roots.
Topics: Antiviral Agents; Biphenyl Compounds; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Humans; Inhibitory Concentration 50; Lamivudine; Lignans; Molecular Structure; Moraceae; Phytotherapy; Plant Extracts; Plant Roots; Plant Structures | 2012 |
Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells.
Topics: Animals; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Down-Regulation; Drugs, Chinese Herbal; HCT116 Cells; Humans; Immunohistochemistry; Lignans; Male; Mice; Mice, Nude; Neoplastic Stem Cells; Nitric Oxide Synthase; Signal Transduction; Transfection; Xenograft Model Antitumor Assays | 2012 |
Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Biphenyl Compounds; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Enzyme Activation; Female; Gene Expression; Humans; Lignans; Mice; Mice, Nude; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Spheroids, Cellular; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.
Topics: Animals; Biphenyl Compounds; Drugs, Chinese Herbal; GABA Agents; HEK293 Cells; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Lignans; Neurons; Rats; Receptors, GABA-A; Synaptic Transmission | 2012 |
Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Electrophoretic Mobility Shift Assay; Female; Humans; Leukemia-Lymphoma, Adult T-Cell; Lignans; Mice; Mice, Inbred ICR; Mice, SCID; NF-kappa B; Signal Transduction; Tumor Cells, Cultured | 2012 |
Comparative studies on the interactions of honokiol and magnolol with human serum albumin.
Topics: Biphenyl Compounds; Circular Dichroism; Humans; Hydrophobic and Hydrophilic Interactions; Lignans; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Static Electricity | 2012 |
In vitro growth inhibition of human cancer cells by novel honokiol analogs.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Inhibitory Concentration 50; Lignans; Lung Neoplasms; Molecular Structure; Structure-Activity Relationship | 2012 |
Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Flumazenil; GABA Modulators; Gene Expression; Injections, Intraperitoneal; Lignans; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Receptors, GABA-A; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Time Factors | 2012 |
Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Camptothecin; Cell Line, Tumor; Coloring Agents; Dimethyl Sulfoxide; Drug Screening Assays, Antitumor; Emodin; Gene Expression; Humans; Lignans; Naphthoquinones; Rotenone; Tetrazolium Salts; Thiazoles; Transcriptional Activation; Tumor Suppressor Protein p53; Zebrafish | 2012 |
Honokiol inhibits HIF pathway and hypoxia-induced expression of histone lysine demethylases.
Topics: Angiogenesis Inhibitors; Biphenyl Compounds; Cell Hypoxia; Cell Line; Cell Line, Tumor; Gene Expression; Histone Demethylases; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Lignans; Neovascularization, Pathologic; Oxygen | 2012 |
Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?
Topics: Alzheimer Disease; Animals; Biphenyl Compounds; Humans; Inflammation; Lignans; Plants, Medicinal; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2012 |
Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Barrett Esophagus; Biphenyl Compounds; Cell Line, Tumor; Cell Transformation, Neoplastic; Esophageal Neoplasms; Humans; Lignans; Signal Transduction; STAT3 Transcription Factor | 2012 |
Surface enhancement of WO3 nanowires toward the oxidation and electrochemical detection of honokiol in traditional Chinese medicine.
Topics: Biphenyl Compounds; Carbon; Drugs, Chinese Herbal; Electrochemical Techniques; Electrodes; Humans; Hydrogen-Ion Concentration; Lignans; Limit of Detection; Medicine, Chinese Traditional; Microscopy, Electron, Scanning; Nanowires; Oxidation-Reduction; Oxides; Surface Properties; Tungsten | 2012 |
[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
Topics: Abietanes; Acetophenones; Antineoplastic Agents, Phytogenic; Benzylisoquinolines; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Curcumin; Diterpenes, Kaurane; Drugs, Chinese Herbal; HL-60 Cells; Humans; K562 Cells; Leukemia; Lignans; Plants, Medicinal | 2012 |
Honokiol inhibits vascular vessel formation of mouse embryonic stem cell-derived endothelial cells via the suppression of PECAM and MAPK/mTOR signaling pathway.
Topics: Angiogenesis Inhibitors; Animals; Biphenyl Compounds; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Endothelial Cells; Lignans; Mice; Mitogen-Activated Protein Kinase Kinases; Platelet Endothelial Cell Adhesion Molecule-1; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Time and dose-response effects of honokiol on UVB-induced skin cancer development.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Lignans; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Skin Neoplasms; Tumor Burden; Ultraviolet Rays; Weight Gain | 2012 |
Honokiol exerts an anticancer effect in T98G human glioblastoma cells through the induction of apoptosis and the regulation of adhesion molecules.
Topics: Apoptosis; Biphenyl Compounds; Blood-Brain Barrier; Brain Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Lignans; Magnolia; Plant Extracts; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2012 |
Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.
Topics: Administration, Oral; Animals; Anthraquinones; Biphenyl Compounds; Drug Incompatibility; Emodin; Flavanones; Hesperidin; Lignans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley | 2012 |
Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.
Topics: Animals; Apoptosis; Biphenyl Compounds; Calpain; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Mice; Neovascularization, Pathologic; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Stomach Neoplasms; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Line, Tumor; Daunorubicin; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lignans; Magnolia; Plant Extracts | 2012 |
Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction.
Topics: Animals; Biphenyl Compounds; Bisbenzimidazole; Blotting, Western; Cell Hypoxia; Cells, Cultured; Central Nervous System Depressants; Cerebral Cortex; Coloring Agents; Cytosol; Disks Large Homolog 4 Protein; Glucose; Glutamic Acid; Immunoprecipitation; In Vitro Techniques; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Lignans; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Translocation, Genetic | 2013 |
Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo.
Topics: Acetylation; Animals; Biphenyl Compounds; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Lignans; Liver Neoplasms; Mice; Mice, Nude; Proteasome Endopeptidase Complex; Proteolysis; Valproic Acid; Xenograft Model Antitumor Assays | 2013 |
Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells.
Topics: Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents, Phytogenic; Autophagy; Biomarkers, Tumor; Biphenyl Compounds; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Down-Regulation; Immunoblotting; Lignans; Melanoma; Mice; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death.
Topics: Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cyclophilins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Female; Humans; Lignans; MCF-7 Cells; Peptidyl-Prolyl Isomerase F | 2013 |
[The relationship between the quality and the leaf shape of Magnolia officinalis produced in Hubei enshi].
Topics: Biphenyl Compounds; China; Chromatography, High Pressure Liquid; Lignans; Magnolia; Plant Bark; Plant Leaves; Plants, Medicinal; Quality Control | 2012 |
Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Biphenyl Compounds; Brain Edema; Brain Ischemia; Capillary Permeability; Chemokine CCL5; Coculture Techniques; Cytokines; Drugs, Chinese Herbal; Female; Inflammation; Lignans; Male; Mice; Microglia; Neuroglia; NF-kappa B; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2013 |
Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells.
Topics: Apoptosis; Biphenyl Compounds; Caspases; Cell Line, Tumor; Cell Membrane; Cytoplasm; Endoplasmic Reticulum; Humans; Leukemia; Lignans; Metabolic Networks and Pathways; Necrosis; Phosphatidylserines; Reactive Oxygen Species; Vacuoles | 2013 |
Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biphenyl Compounds; Cell Line, Transformed; Cells, Cultured; Inflammation; Inflammation Mediators; Lignans; Magnolia; Mice; Microglia; Neurons; Oxidative Stress; Polyphenols; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Survival; Cells, Cultured; Female; Humans; In Vitro Techniques; Keratinocytes; Lignans; Mice; Mice, Nude; Neutrophils; Pancreatic Elastase; Skin; Skin Absorption; Skin Irritancy Tests; Superoxides; Swine; Young Adult | 2013 |
Screening active anti-breast cancer compounds from Cortex Magnolia officinalis by 2D LC-MS.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Humans; Lignans; Magnolia; Mass Spectrometry | 2013 |
Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling.
Topics: Animals; Biphenyl Compounds; Calcium; Calcium Signaling; CHO Cells; Cricetinae; Cytoplasm; Gene Expression Regulation; Humans; Inositol 1,4,5-Trisphosphate; Ion Transport; Lignans; Receptor, Muscarinic M3 | 2013 |
Characterization, pharmacokinetics, tissue distribution and antitumor activity of honokiol submicron lipid emulsions in tumor-burdened mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Biphenyl Compounds; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drug Compounding; Drug Stability; Electrochemistry; Emulsions; Hydrogen-Ion Concentration; Injections, Intravenous; Lignans; Mice; Neoplasms, Experimental; Osmolar Concentration; Particle Size; Reproducibility of Results; Soybean Oil; Tissue Distribution | 2013 |
Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; BH3 Interacting Domain Death Agonist Protein; Biphenyl Compounds; Cell Death; Cell Line; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; JNK Mitogen-Activated Protein Kinases; Lignans; Magnoliaceae; Membrane Potential, Mitochondrial; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenyl Ethers; Phosphorylation; Picrates; Plant Extracts; Reactive Oxygen Species; Signal Transduction | 2013 |
Cyclophilin D modulates cell death transition from early apoptosis to programmed necrosis induced by honokiol.
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cyclophilins; Humans; Lignans; Necrosis; Peptidyl-Prolyl Isomerase F; Receptor-Interacting Protein Serine-Threonine Kinases | 2013 |
Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Humans; Lignans; Mesothelioma; Pleural Neoplasms; Signal Transduction; Sp1 Transcription Factor | 2013 |
Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE₂-mediated activation of β-catenin signaling.
Topics: beta Catenin; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drugs, Chinese Herbal; Gene Knockdown Techniques; Humans; Lignans; Lung Neoplasms; Neoplasm Invasiveness; RNA Interference; Signal Transduction; Sulfonamides; Transcription Factor RelA | 2013 |
Mitochondrial dysfunction induced by honokiol.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Lignans; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Membranes; Oxygen Consumption; Permeability; Rats; Rats, Wistar | 2013 |
Identification of metabolites of honokiol in rat urine using 13C stable isotope labeling and liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
Topics: Animals; Biotransformation; Biphenyl Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Isotope Labeling; Lignans; Magnolia; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2013 |
[Study on the chemical constituents of Elephantopus mollis].
Topics: Asteraceae; Betulinic Acid; Biphenyl Compounds; Dibutyl Phthalate; Flavonoids; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Pentacyclic Triterpenes; Triterpenes | 2012 |
Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carbon; Dimerization; Ethanol; Humans; Inhibitory Concentration 50; Lignans; Magnolia; Neutrophils; Pancreatic Elastase; Plant Roots; Superoxides; Young Adult | 2013 |
Effect of honokiol on erythrocytes.
Topics: Biphenyl Compounds; Calcium; Cell Death; Cell Size; Cells, Cultured; Erythrocytes; Hemolysis; Humans; Lignans; Phosphatidylserines | 2013 |
The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways.
Topics: Apoptosis; Biphenyl Compounds; Calcineurin; Calcineurin Inhibitors; Cell Line, Tumor; Cell Proliferation; Cyclosporine; Down-Regulation; Gene Expression Regulation; Genes, ras; Heme Oxygenase-1; Humans; Kidney Neoplasms; Lignans; Phosphorylation; Proto-Oncogene Mas; raf Kinases; ras Proteins; Signal Transduction; Transcriptional Activation; Transfection; Vascular Endothelial Growth Factor A | 2013 |
Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Blotting, Western; Caspase 3; Cell Line; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; HT29 Cells; Humans; Lignans; NF-kappa B; Organoplatinum Compounds; Oxaliplatin; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A | 2013 |
Identification of honokiol metabolites in rats by the method of stable isotope cluster technique and ultra-high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Glucuronides; Glutamates; Isotope Labeling; Lignans; Male; Mass Spectrometry; Metabolic Networks and Pathways; Rats; Rats, Sprague-Dawley | 2013 |
Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Catechin; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Lignans; Molecular Targeted Therapy; Molecular Weight; Neoplasms; Protein Binding | 2013 |
Honokiol: a non-adipogenic PPARγ agonist from nature.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Biological Products; Biphenyl Compounds; Cell Differentiation; Diabetes Mellitus, Experimental; HEK293 Cells; Humans; Lignans; Mice; Molecular Docking Simulation; PPAR gamma | 2013 |
Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Immunoprecipitation; Lignans; Luciferases; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Phytotherapy; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured | 2013 |
Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Lignans; Mouth Neoplasms; Plants; Sp1 Transcription Factor | 2013 |
Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.
Topics: Adipogenesis; Adiponectin; Adipose Tissue, White; Adiposity; Animals; Biphenyl Compounds; Blood Glucose; Body Weight; Chemokine CCL2; Cholesterol; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Glucose Tolerance Test; Inflammation; Insulin Resistance; Interleukin-10; Interleukin-6; Lignans; Liver; Male; Mice; Mice, Inbred C57BL; Triglycerides; Tumor Necrosis Factor-alpha | 2013 |
Chemopreventive effects of combination of honokiol and magnolol with α-santalol on skin cancer developments.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Biphenyl Compounds; Cell Proliferation; Drug Therapy, Combination; Female; Lignans; Mice; Neoplasms, Radiation-Induced; Polycyclic Sesquiterpenes; Sesquiterpenes; Skin Neoplasms; Ultraviolet Rays | 2013 |
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model.
Topics: Animals; Antibiotics, Antineoplastic; Biphenyl Compounds; Cell Line; Digoxin; Doxorubicin; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1; Lignans; Mice; Mice, Inbred C57BL; Oxygen; Retina; Retinal Neovascularization; Transcriptional Activation | 2013 |
Honokiol inhibits tumor necrosis factor-α-stimulated rat aortic smooth muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis.
Topics: Animals; Aorta; Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Caspases; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cytochromes c; Drugs, Chinese Herbal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; JNK Mitogen-Activated Protein Kinases; Lignans; Male; Membrane Potential, Mitochondrial; Mitochondria; Muscle, Smooth, Vascular; Nitric Oxide Synthase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2014 |
Effect of honokiol on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes.
Topics: Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Bupropion; Drugs, Chinese Herbal; Enzyme Inhibitors; Ethanolamines; Glucuronosyltransferase; Herb-Drug Interactions; Humans; Hydroxylation; Inactivation, Metabolic; Inhibitory Concentration 50; Lignans; Liver; Microsomes, Liver; Phenacetin | 2013 |
[Simultaneous determination of six ingredients in Huoxiang Zhengqi oral liquid by UPLC].
Topics: Administration, Oral; Biphenyl Compounds; Chromatography, High Pressure Liquid; Disaccharides; Drugs, Chinese Herbal; Flavanones; Glucosides; Hesperidin; Lignans; Pharmaceutical Solutions | 2013 |
Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition.
Topics: Apoptosis; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Membrane Permeability; Endothelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lignans; Neoplasm Invasiveness; Vascular Cell Adhesion Molecule-1 | 2014 |
Discovery of soluble epoxide hydrolase inhibitors from natural products.
Topics: Biological Products; Biphenyl Compounds; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Epoxide Hydrolases; Fluorometry; Lignans; Oleanolic Acid; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2014 |
Honokiol inhibits androgen receptor activity in prostate cancer cells.
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Down-Regulation; Humans; Lignans; Male; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction | 2014 |
Honokiol trimers and dimers via biotransformation catalyzed by Momordica charantia peroxidase: novel and potent α-glucosidase inhibitors.
Topics: alpha-Glucosidases; Biocatalysis; Biphenyl Compounds; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Lignans; Molecular Structure; Momordica charantia; Peroxidase; Saccharomyces cerevisiae; Structure-Activity Relationship | 2014 |
Honokiol suppresses TNF-α-induced migration and matrix metalloproteinase expression by blocking NF-κB activation via the ERK signaling pathway in rat aortic smooth muscle cells.
Topics: Animals; Aorta; Biphenyl Compounds; Lignans; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2014 |
Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes.
Topics: Aged; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Survival; Chondrocytes; Collagen Type II; Drugs, Chinese Herbal; Humans; I-kappa B Kinase; Lignans; Magnolia; Matrix Metalloproteinase 13; Middle Aged; NF-kappa B; Osteoarthritis; Signal Transduction | 2014 |
Magnolia dealbata seeds extract exert cytotoxic and chemopreventive effects on MDA-MB231 breast cancer cells.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; In Situ Nick-End Labeling; Inhibitory Concentration 50; Lignans; Magnolia; Mammary Neoplasms, Experimental; Mice, Nude; Seeds | 2014 |
Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; Glioblastoma; HCT116 Cells; Humans; Inhibitory Concentration 50; Leukemia; Lignans; Methylation; Microwaves | 2014 |
Honokiol nanosuspensions: preparation, increased oral bioavailability and dramatically enhanced biodistribution in the cardio-cerebro-vascular system.
Topics: Administration, Oral; Animals; Biological Availability; Biphenyl Compounds; Calorimetry, Differential Scanning; Cell Line, Tumor; Cerebrovascular Circulation; Coronary Circulation; Kidney; Lignans; Liver; Lung; Male; Mice; Mice, Inbred ICR; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Surface Properties; Suspensions | 2014 |
[Honokiol inhibits the invasion and angiogenesis of U937 leukemia cells].
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Lignans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neovascularization, Pathologic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast; Breast Neoplasms; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Homeodomain Proteins; Humans; Lignans; Magnolia; Signal Transduction; STAT3 Transcription Factor; Transcription Factors; Zinc Finger E-box-Binding Homeobox 1 | 2014 |
Effects of honokiol on sepsis-induced acute kidney injury in an experimental model of sepsis in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Biphenyl Compounds; Cytokines; Disease Models, Animal; Inflammation; Kidney; Lignans; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction | 2014 |
Characterization of metabolic profile of honokiol in rat feces using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and (13)C stable isotope labeling.
Topics: Animals; Biomarkers; Biphenyl Compounds; Carbon Isotopes; Chromatography, Liquid; Feces; Isotope Labeling; Lignans; Male; Metabolome; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Humans; Ki-67 Antigen; Lignans; Mitochondria; Neoplasms; Paclitaxel; Receptors, Death Domain; Signal Transduction; STAT3 Transcription Factor | 2014 |
[Honokiol combined with Gemcitabine synergistically inhibits the proliferation of human Burkitt lymphoma cells and induces their apoptosis].
Topics: Apoptosis; Biphenyl Compounds; Burkitt Lymphoma; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Lignans; Proto-Oncogene Proteins c-bcl-2 | 2014 |
w007B protects brain against ischemia-reperfusion injury in rats through inhibiting inflammation, apoptosis and autophagy.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Body Weight; Cerebrovascular Circulation; Disease Models, Animal; Female; Inflammation; Lignans; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sex Factors; Time Factors | 2014 |
Multiwalled-carbon-nanotubes-based matrix solid-phase dispersion extraction coupled with high-performance liquid chromatography for the determination of honokiol and magnolol in Magnoliae Cortex.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Lignans; Magnolia; Nanotubes, Carbon; Plant Extracts; Solid Phase Extraction | 2014 |
Pharmacokinetics of honokiol after intravenous guttae in beagle dogs assessed using ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Administration, Intravenous; Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dogs; Female; Lignans; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2014 |
Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid.
Topics: Animals; Antidiarrheals; Berberine; Biphenyl Compounds; Coptis; Diarrhea; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Intestines; Lignans; Magnolia; Male; Peristalsis; Phytotherapy; Swine | 2014 |
Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations.
Topics: Antineoplastic Agents; Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drug Compounding; Drug Contamination; Lignans; Quercetin; Solvents | 2014 |
Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Proliferation; Epithelial-Mesenchymal Transition; Homeodomain Proteins; Humans; Kidney Neoplasms; Lignans; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplastic Stem Cells; Repressor Proteins; Signal Transduction; Tumor Burden; Zinc Finger E-box Binding Homeobox 2 | 2014 |
A natural-product switch for a dynamic protein interface.
Topics: Binding Sites; Biological Products; Biphenyl Compounds; Crystallography, X-Ray; Ligands; Lignans; Models, Biological; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors | 2014 |
Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Inhibitor of Apoptosis Proteins; Lignans; Signal Transduction; Survivin; Tumor Suppressor Protein p53 | 2014 |
Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.
Topics: Animals; Biphenyl Compounds; GABA-A Receptor Agonists; Gastrointestinal Agents; Humans; Lignans; Magnolia; Membrane Potentials; Plant Bark; Receptors, GABA-A; Xenopus laevis | 2014 |
Intravenous administration of Honokiol provides neuroprotection and improves functional recovery after traumatic brain injury through cell cycle inhibition.
Topics: Administration, Intravenous; Animals; Apoptosis; Biphenyl Compounds; Brain Injuries; Cell Cycle; Cell Survival; Cerebral Cortex; Cognition; Disease Models, Animal; Hippocampus; Lignans; Male; Motor Activity; Neurons; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Recovery of Function | 2014 |
Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells.
Topics: Animals; Autophagy; Biphenyl Compounds; Cell Line, Tumor; Cytoprotection; Drugs, Chinese Herbal; Humans; Lignans; Male; Mice; Mice, Transgenic; Prostatic Neoplasms; Reactive Oxygen Species | 2014 |
UPLC-MS/MS-ESI assay for simultaneous determination of magnolol and honokiol in rat plasma: application to pharmacokinetic study after administration emulsion of the isomer.
Topics: Administration, Intravenous; Administration, Oral; Animals; Biphenyl Compounds; Chromatography, Liquid; Emulsions; Lignans; Male; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Calcium; Calcium Signaling; Cell Line, Tumor; Cell Survival; Estrenes; Glioblastoma; Homeostasis; Humans; Lignans; Phosphodiesterase Inhibitors; Pyrrolidinones; Up-Regulation | 2014 |
Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway.
Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Line; Diet, High-Fat; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fatty Liver; Hepatocytes; Humans; Lignans; Lipogenesis; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2015 |
Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lignans; MAP Kinase Signaling System; STAT3 Transcription Factor | 2014 |
Honokiol induces cell cycle arrest and apoptosis via inhibiting class I histone deacetylases in acute myeloid leukemia.
Topics: Acute Disease; Adult; Aged; Animals; Apoptosis; bcl-2-Associated X Protein; Biocatalysis; Biphenyl Compounds; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; Female; Histone Deacetylases; Humans; K562 Cells; Leukemia, Myeloid; Lignans; Male; Mice, Nude; Middle Aged; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
A new dimeric neolignan from Magnolia grandiflora L. seeds.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Screening Assays, Antitumor; Humans; Lignans; Magnolia; Molecular Conformation; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Seeds | 2015 |
Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans; Magnolia; Polyethylene Glycols; Ultrasonics | 2015 |
Construction of an immobilised acetylcholinesterase column and its application in screening insecticidal constituents from Magnolia officinalis.
Topics: Acetylcholinesterase; Alkaloids; Animals; Biphenyl Compounds; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Female; Hemiptera; Insecticides; Lignans; Magnolia; Plant Extracts; Sesquiterpenes | 2015 |
Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Anticarcinogenic Agents; Apoptosis; Biphenyl Compounds; Bronchi; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Caspase 3; Caspase 7; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Humans; Lignans; Lung Neoplasms; Mice; Mitochondria; Neoplasm Transplantation; Oxidation-Reduction; Reactive Oxygen Species | 2014 |
Investigation of inclusion complex of honokiol with sulfobutyl ether-β-cyclodextrin.
Topics: Animals; beta-Cyclodextrins; Biological Availability; Biphenyl Compounds; Calorimetry, Differential Scanning; Drug Delivery Systems; Drug Liberation; Freeze Drying; Lignans; Male; Rats; Solubility; Spectroscopy, Fourier Transform Infrared | 2014 |
Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes.
Topics: Biphenyl Compounds; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Hepatocytes; Humans; Lignans; Pharmaceutical Preparations; RNA, Messenger; Sulfotransferases | 2014 |
Evaluation of anti-HIF and anti-angiogenic properties of honokiol for the treatment of ocular neovascular diseases.
Topics: Angiogenesis Inhibitors; Biphenyl Compounds; Cell Line; Cell Movement; Cell Proliferation; Endothelium, Vascular; Eye Diseases; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Lignans; Luciferases; Neovascularization, Pathologic; Retinal Pigment Epithelium | 2014 |
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lignans; Magnolia; Molecular Docking Simulation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Signal Transduction; Transcriptome; Tumor Suppressor Protein p53 | 2014 |
Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disease Models, Animal; Glutathione; Hippocampus; Inflammation; Interleukin-1beta; Interleukin-6; Lignans; Lipid Peroxidation; Lipopolysaccharides; Mice; Nitrites; Oxidative Stress; Prefrontal Cortex; Tumor Necrosis Factor-alpha | 2014 |
Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Immunoblotting; Lignans; Melanoma; Melanoma, Cutaneous Malignant; Microscopy, Electron, Scanning; Signal Transduction; Skin Neoplasms | 2014 |
Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors.
Topics: Allosteric Regulation; Animals; Biological Products; Biphenyl Compounds; Lignans; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Isoforms; Receptors, GABA-A; Structure-Activity Relationship; Xenopus | 2014 |
Potential use of Magnolia officinalis bark polyphenols in the treatment of cannabis dependence.
Topics: Animals; Biphenyl Compounds; Cannabis; Humans; Inflammation; Lignans; Magnolia; Marijuana Abuse; Plant Bark; Plant Extracts; Polyphenols; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2014 |
Acute and sub-chronic toxicity studies of honokiol microemulsion.
Topics: Animals; Biphenyl Compounds; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Emulsions; Injections, Intravenous; Lethal Dose 50; Lignans; Mice, Inbred ICR; No-Observed-Adverse-Effect Level; Rats, Sprague-Dawley; Risk Assessment; Time Factors; Toxicity Tests, Acute; Toxicity Tests, Subchronic | 2015 |
Honokiol inhibits melanoma stem cells by targeting notch signaling.
Topics: ADAM Proteins; ADAM17 Protein; Amyloid Precursor Protein Secretases; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Homeodomain Proteins; Humans; Lignans; Melanoma; Neoplastic Stem Cells; Receptor, Notch2; Receptors, Notch; Signal Transduction; Transcription Factor HES-1 | 2015 |
Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; GABA Modulators; Lignans; Metals; Molecular Structure; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 2015 |
[Effect of honokiol on proliferation and apoptosis in HL-60 cells and its potential mechanism].
Topics: Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Caspase 3; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; HL-60 Cells; Humans; Lignans; Oncogene Proteins; Signal Transduction | 2014 |
The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA).
Topics: Animals; Anti-Bacterial Agents; Biphenyl Compounds; Caenorhabditis elegans; Cytokines; Humans; Lignans; Macrophages; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mice; Plant Extracts; Plants, Medicinal; Staphylococcal Infections; Staphylococcus aureus | 2015 |
Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition.
Topics: Adult; Animals; Biomarkers, Tumor; Biphenyl Compounds; Calpain; Calreticulin; Cell Death; Cell Line, Tumor; Down-Regulation; Endoplasmic Reticulum Stress; Epithelial-Mesenchymal Transition; Female; Gene Knockdown Techniques; Humans; Lignans; Macrophages; Male; Methylnitronitrosoguanidine; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Neoplasm Invasiveness; Phagocytosis; PPAR gamma; Promoter Regions, Genetic; Protein Binding; Stomach Neoplasms; Up-Regulation | 2015 |
Honokiol decreases intra-abdominal adhesion formation in a rat model.
Topics: Animals; Antioxidants; Biphenyl Compounds; Disease Models, Animal; Female; Lignans; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tissue Adhesions; Uterus | 2015 |
Effects of magnolol and honokiol on adhesion, yeast-hyphal transition, and formation of biofilm by Candida albicans.
Topics: Animals; Antifungal Agents; Biofilms; Biphenyl Compounds; Caenorhabditis elegans; Candida albicans; Cell Adhesion; Cell Line; Drugs, Chinese Herbal; Fungal Proteins; Hyphae; Lignans; Microscopy, Confocal; Models, Animal; Rats; Signal Transduction; Titanium; Virulence | 2015 |
Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Line, Tumor; Diet, High-Fat; Fatty Acid Synthases; Fatty Acids, Nonesterified; Hep G2 Cells; Hepatocytes; Humans; Lignans; Lipid Metabolism; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Stearoyl-CoA Desaturase; Sterol Regulatory Element Binding Protein 1; Triglycerides | 2015 |
Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by Honokiol in glioblastoma multiforme cells.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Biphenyl Compounds; Brain Neoplasms; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Glioblastoma; Homeodomain Proteins; Humans; Lignans; Neoplastic Stem Cells; Receptor, Notch3; Receptors, Notch; Temozolomide; Transcription Factor HES-1; Tumor Cells, Cultured | 2015 |
Magnolol and honokiol regulate the calcium-activated potassium channels signaling pathway in Enterotoxigenic Escherichia coli-induced diarrhea mice.
Topics: Animals; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Chlorides; Diarrhea; Enterotoxigenic Escherichia coli; Escherichia coli Infections; Ileum; Inositol 1,4,5-Trisphosphate Receptors; Lignans; Male; Mice; Potassium; Potassium Channels, Calcium-Activated; Protein Kinase C; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Sodium | 2015 |
Honokiol downregulates Kruppel-like factor 4 expression, attenuates inflammation, and reduces histopathology after spinal cord injury in rats.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cytokines; Down-Regulation; Female; Inflammation; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lignans; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2015 |
Co-delivery of honokiol, a constituent of Magnolia species, in a self-microemulsifying drug delivery system for improved oral transport of lipophilic sirolimus.
Topics: Administration, Oral; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biphenyl Compounds; Caco-2 Cells; Drug Delivery Systems; Emulsions; Humans; Intestinal Absorption; Lignans; Magnolia; Permeability; Sirolimus; Solubility | 2016 |
Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Kisspeptins; Lignans; Neoplasm Invasiveness; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Signal Transduction | 2015 |
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Topics: Acetylation; Adenosine Triphosphatases; Animals; Biphenyl Compounds; Cardiomegaly; Cardiotonic Agents; Carrier Proteins; Cell Differentiation; Cell Proliferation; Enzyme Activation; Fibroblasts; Gene Expression Regulation; Isoproterenol; Lignans; Membrane Proteins; Mice; Mitochondria; Mitochondrial Proton-Translocating ATPases; Myocardium; Myocytes, Cardiac; Myofibroblasts; Phenylephrine; Primary Cell Culture; Reactive Oxygen Species; Signal Transduction; Sirtuin 3; Superoxide Dismutase | 2015 |
Synthesis of benzoxazole derivatives of honokiol as insecticidal agents against Mythimna separata Walker.
Topics: Animals; Benzoxazoles; Biphenyl Compounds; Insecticides; Larva; Lignans; Molecular Structure; Moths | 2015 |
Multifunctional effects of honokiol as an anti-inflammatory and anti-cancer drug in human oral squamous cancer cells and xenograft.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Calcium; Carcinoma, Squamous Cell; Chromatography, Liquid; Humans; Lignans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Mouth Neoplasms; NF-kappa B; Nitric Oxide Synthase Type II; Oxidation-Reduction; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays | 2015 |
Honokiol improves learning and memory impairments induced by scopolamine in mice.
Topics: Animals; Biphenyl Compounds; Brain; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Lignans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Scopolamine | 2015 |
New mechanism of magnolol and honokiol from Magnolia officinalis against Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Biphenyl Compounds; Humans; Lignans; Magnolia; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Plant Exudates; Staphylococcal Infections; Staphylococcus aureus | 2014 |
The Pharmacokinetics and Tissue Distribution of Honokiol and its Metabolites in Rats.
Topics: Animals; Biphenyl Compounds; Brain; Glucuronic Acid; Kidney; Lignans; Liver; Magnolia; Male; Plasma; Rats; Rats, Wistar; Sulfuric Acids; Tissue Distribution | 2016 |
The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Calcium; Cathepsin G; Cell Movement; Cyclic AMP; Humans; Lignans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipase C gamma; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Formyl Peptide; Respiratory Burst; src-Family Kinases; Superoxides; Young Adult | 2015 |
A novel 9 × 9 map-based solvent selection strategy for targeted counter-current chromatography isolation of natural products.
Topics: Abietanes; Biological Products; Biphenyl Compounds; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Countercurrent Distribution; Hexanes; Lignans; Magnolia; Methanol; Reproducibility of Results; Salvia miltiorrhiza; Solvents; Water | 2015 |
Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cell Survival; Dose-Response Relationship, Drug; ErbB Receptors; Female; Flow Cytometry; Head and Neck Neoplasms; Humans; Lignans; Magnolia; Mice; Mice, Nude; Molecular Docking Simulation; Phytotherapy; Plant Extracts; Signal Transduction; Sirolimus | 2015 |
Semisynthesis and insecticidal activity of arylmethylamine derivatives of the neolignan honokiol against Mythimna separata Walker.
Topics: Animals; Biphenyl Compounds; Drugs, Chinese Herbal; Insecticides; Larva; Lepidoptera; Lignans | 2015 |
Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner.
Topics: Animals; Antineoplastic Agents, Phytogenic; beta Catenin; Biphenyl Compounds; Breast Neoplasms; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1; Drugs, Chinese Herbal; Female; Histone Deacetylases; Humans; Leptin; Lignans; Magnolia; MCF-7 Cells; Mice; Mice, Nude; Mice, Obese; MicroRNAs; Neoplasm Invasiveness; Obesity; Phosphorylation; Plant Extracts; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Spheroids, Cellular; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Wnt1 Protein; Xenograft Model Antitumor Assays | 2015 |
Certification of a new certified reference material of honokiol.
Topics: Biphenyl Compounds; Certification; Chromatography, High Pressure Liquid; Lignans; Reference Standards | 2015 |
Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lignans; Mice; Neoplasm Proteins; Xenograft Model Antitumor Assays | 2015 |
Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model.
Topics: Apoptosis; Atherosclerosis; Biphenyl Compounds; C-Reactive Protein; Down-Regulation; Drugs, Chinese Herbal; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Kinase; Lignans; Magnolia; NF-kappaB-Inducing Kinase; Palmitic Acid; Protein Serine-Threonine Kinases; Serum Amyloid P-Component; Signal Transduction | 2015 |
Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in Zhi-Zi-Hou-Po Decoction to rats.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Brain Chemistry; Chromatography, High Pressure Liquid; Drug Interactions; Drugs, Chinese Herbal; Iridoids; Lignans; Magnolia; Male; Plant Extracts; Rats; Tissue Distribution | 2016 |
Anti-psoriatic effects of Honokiol through the inhibition of NF-κB and VEGFR-2 in animal model of K14-VEGF transgenic mouse.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; CD4-Positive T-Lymphocytes; Cells, Cultured; Disease Models, Animal; Down-Regulation; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Magnolia; Mice, Transgenic; Molecular Targeted Therapy; NF-kappa B; Phosphorylation; Phytotherapy; Psoriasis; Th1-Th2 Balance; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan.
Topics: Animals; Anthraquinones; Biphenyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Glycosides; Lignans; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2015 |
Screening of natural compounds with neuronal differentiation promoting effects in a cell-based model.
Topics: Animals; Biphenyl Compounds; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Embryonal Carcinoma Stem Cells; Lignans; Mice; Neurons; Quercetin; Tretinoin; Wnt Signaling Pathway | 2015 |
Inhibitory effects of magnolol and honokiol on human calcitonin aggregation.
Topics: Biphenyl Compounds; Calcitonin; Calorimetry; Cell Line, Tumor; Dynamic Light Scattering; Humans; Lignans; Magnolia; Medicine, Chinese Traditional; Microscopy, Electron, Transmission; Polyphenols; Protein Binding | 2015 |
Honokiol possesses potential anti-inflammatory effects on rheumatoid arthritis and GM-CSF can be a target for its treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biphenyl Compounds; Case-Control Studies; Cells, Cultured; Dose-Response Relationship, Drug; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-8; Leukocytes, Mononuclear; Lignans; Male; Middle Aged; Primary Cell Culture; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Encapsulation of honokiol into self-assembled pectin nanoparticles for drug delivery to HepG2 cells.
Topics: Apoptosis; Binding, Competitive; Biological Transport; Biphenyl Compounds; Capsules; Cell Survival; Drug Carriers; Drug Liberation; Hep G2 Cells; Humans; Lignans; Nanoparticles; Pectins | 2015 |
Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus.
Topics: Anti-Infective Agents; Biphenyl Compounds; Hexanes; Lignans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxacillin; Plant Extracts | 2015 |
Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Leptin; Lignans; MCF-7 Cells; Mice; MicroRNAs; Microscopy, Confocal; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Xenograft Model Antitumor Assays | 2015 |
Honokiol, a Lignan Biphenol Derived from the Magnolia Tree, Inhibits Dengue Virus Type 2 Infection.
Topics: Animals; Antiviral Agents; Biphenyl Compounds; Cells, Cultured; Cricetinae; Dengue Virus; Gene Expression Regulation, Viral; Humans; Lignans; Magnolia; Virus Internalization; Virus Replication | 2015 |
Nitrogenated honokiol derivatives allosterically modulate GABAA receptors and act as strong partial agonists.
Topics: Allosteric Regulation; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Partial Agonism; Female; GABA-A Receptor Agonists; Lignans; Magnolia; Molecular Structure; Nitrogen; Oocytes; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2015 |
Effect of honokiol on exotoxin proteins listeriolysin O and p60 secreted by Listeria monocytogenes.
Topics: Animals; Anti-Infective Agents; Bacterial Proteins; Bacterial Toxins; Biphenyl Compounds; Cell Line; Gene Expression Regulation, Bacterial; Heat-Shock Proteins; Hemolysin Proteins; Lignans; Listeria monocytogenes; Macrophages; Mice; Microbial Sensitivity Tests; Milk; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2015 |
Antioxidant Activity of Magnolol and Honokiol: Kinetic and Mechanistic Investigations of Their Reaction with Peroxyl Radicals.
Topics: Acetonitriles; Anisoles; Antioxidants; Biphenyl Compounds; Hydrogen Bonding; Kinetics; Lignans; Molecular Structure; Oxidation-Reduction; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Superoxides | 2015 |
Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Cell Line, Tumor; Cell Movement; Endoplasmic Reticulum Stress; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; Mice; Neuroblastoma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Sirolimus-loaded polymeric micelles with honokiol for oral delivery.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biphenyl Compounds; Caco-2 Cells; Cell Survival; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Stability; Humans; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kinetics; Lignans; Male; Micelles; Particle Size; Permeability; Polyesters; Polyethylene Glycols; Rats, Sprague-Dawley; Sirolimus; Solubility | 2015 |
Honokiol Inhibits Constitutive and Inducible STAT3 Signaling via PU.1-Induced SHP1 Expression in Acute Myeloid Leukemia Cells.
Topics: Adult; Aged; Biphenyl Compounds; Blast Crisis; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Leukemia, Myeloid, Acute; Lignans; Male; Middle Aged; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Up-Regulation; Vanadates | 2015 |
Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Biphenyl Compounds; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Lignans; Male; Matrix Metalloproteinase 9; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Signal Transduction; SOXB1 Transcription Factors; Time Factors; Transcription, Genetic; Tumor Burden; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2015 |
Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression.
Topics: Animals; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Hep G2 Cells; Humans; Lignans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nuclear Receptor Subfamily 4, Group A, Member 1; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2016 |
Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.
Topics: Analgesics; Animals; Biphenyl Compounds; Formaldehyde; Lignans; Magnolia; Male; Molecular Structure; Neuroprotective Agents; Pain; Rats | 2015 |
Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans.
Topics: Anti-Bacterial Agents; Biofilms; Biphenyl Compounds; Cell Line; Dose-Response Relationship, Drug; Gingiva; Humans; Lignans; Magnolia; Microbial Sensitivity Tests; Microscopy, Fluorescence; Plant Bark; Plant Extracts; Streptococcus mutans | 2016 |
[Transglycosylation of neolignans by enzymatic synthesis and evaluation of their antitumor activity].
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Chromatography, High Pressure Liquid; Glucosides; Glycosylation; Humans; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2015 |
Embryo-fetal development toxicity of honokiol microemulsion intravenously administered to pregnant rats.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Embryo, Mammalian; Emulsions; Female; Fetus; Gestational Age; Injections, Intravenous; Lignans; Maternal Exposure; Neuroprotective Agents; No-Observed-Adverse-Effect Level; Pregnancy; Rats, Sprague-Dawley; Risk Assessment | 2016 |
In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Anti-Bacterial Agents; Biphenyl Compounds; Drug Synergism; Lignans; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests | 2015 |
New in vitro insights on a cell death pathway induced by magnolol and honokiol in aristolochic acid tubulotoxicity.
Topics: Aristolochic Acids; Biphenyl Compounds; Cell Cycle; Cell Line; Free Radical Scavengers; Humans; Kidney Tubules; Lignans; Molecular Structure; Oxidative Stress; Picrates | 2016 |
Honokiol abrogates chronic restraint stress-induced cognitive impairment and depressive-like behaviour by blocking endoplasmic reticulum stress in the hippocampus of mice.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cognition Disorders; Cytokines; Depression; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression Regulation; Heat-Shock Proteins; Hippocampus; Imipramine; Lignans; Male; Mice; Restraint, Physical; Stress, Psychological; Transcription Factor CHOP | 2016 |
Honokiol protects against renal ischemia/reperfusion injury via the suppression of oxidative stress, iNOS, inflammation and STAT3 in rats.
Topics: Animals; Biphenyl Compounds; Gene Expression Regulation; Humans; Inflammation; Kidney; Lignans; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Reperfusion Injury; STAT3 Transcription Factor | 2016 |
In vitro Penetration and in vivo Distribution of Honokiol into the Intervertebral Disc in Rat.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; In Vitro Techniques; Injections, Intravenous; Intervertebral Disc; Lignans; Male; Molecular Structure; Permeability; Rats, Sprague-Dawley; Time Factors; Tissue Distribution | 2015 |
[Quality Suitability of Magnolia officinalis in China Based on GIS].
Topics: Biphenyl Compounds; China; Geographic Information Systems; Lignans; Magnolia | 2015 |
Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypoglycemic Agents; Injections, Intraperitoneal; Lignans; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Streptozocin; Structure-Activity Relationship | 2015 |
Quality evaluation of the leaves of Magnolia officinalis var. biloba using high-performance liquid chromatography fingerprint analysis of phenolic compounds.
Topics: Biphenyl Compounds; China; Chromatography; Chromatography, High Pressure Liquid; Glucosides; Lignans; Magnolia; Mannosides; Phenols; Plant Extracts; Plant Leaves; Proanthocyanidins; Quercetin; Reference Values; Reproducibility of Results; Rutin; Temperature | 2016 |
Protective effects of honokiol against methylglyoxal-induced osteoblast damage.
Topics: Animals; Biphenyl Compounds; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Lignans; Mice; Osteoblasts; Protective Agents; Pyruvaldehyde; Structure-Activity Relationship | 2016 |
Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells.
Topics: Animals; Apoptosis; Biphenyl Compounds; Blotting, Western; Cell Membrane; Cell Movement; Cell Proliferation; Cytosol; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Lignans; Melanoma; Mice; Mice, Nude; NADPH Oxidase 1; NADPH Oxidases; Oxidative Stress; Protein Binding; Reactive Oxygen Species; Tumor Cells, Cultured; Wound Healing; Xenograft Model Antitumor Assays | 2016 |
Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biphenyl Compounds; Cell Survival; Flavonoids; Fluorescent Dyes; Hydrolyzable Tannins; Lignans; Luteolin; Microscopy, Electron, Transmission; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Polyphenols; Rats; Thiazoles | 2016 |
Protective effect of Honokiol against endometriosis in Rats via attenuating Survivin and Bcl-2: A mechanistic study.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Endometriosis; Endometrium; Female; Lignans; Microtubule-Associated Proteins; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Survivin | 2016 |
Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Indoles; Lignans; Melanoma; Mice; Signal Transduction; Sulfonamides; Vemurafenib; Xenograft Model Antitumor Assays | 2016 |
mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Biphenyl Compounds; Blotting, Western; Caspase 3; Caspase 8; Cyclophilins; Cyclosporine; HEK293 Cells; Humans; Imidazoles; Indoles; Lignans; Mitochondria; Nuclear Pore Complex Proteins; Peptidyl-Prolyl Isomerase F; Permeability; RNA-Binding Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Comparative metabolism of honokiol in mouse, rat, dog, monkey, and human hepatocytes.
Topics: Animals; Arylsulfotransferase; Biotransformation; Biphenyl Compounds; Cells, Cultured; Chromatography, Liquid; Dogs; Glucuronides; Glucuronosyltransferase; Haplorhini; Hepatocytes; Humans; Lignans; Mice; Oxidation-Reduction; Rats; Species Specificity; Sulfuric Acid Esters; Tandem Mass Spectrometry | 2016 |
Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Janus Kinases; Lignans; Mice; Mouth Neoplasms; Neoplasm Proteins; Neoplastic Stem Cells; Side-Population Cells; STAT Transcription Factors; Xenograft Model Antitumor Assays | 2016 |
Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study.
Topics: Animals; Biphenyl Compounds; Female; Lignans; Ovarian Diseases; Protective Factors; Rats; Rats, Wistar; Reperfusion Injury | 2016 |
Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis.
Topics: Animals; Apoptosis; Benzothiazoles; Biphenyl Compounds; Caspases; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Down-Regulation; Drug Evaluation, Preclinical; Female; G1 Phase; Glioblastoma; Humans; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; Toluene; Tumor Suppressor Protein p53 | 2016 |
Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Glioblastoma; Humans; Lignans; Mice; Mice, Nude; Xenograft Model Antitumor Assays | 2016 |
Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; G1 Phase Cell Cycle Checkpoints; Humans; Lignans; Liver Neoplasms; PPAR gamma; Rosiglitazone; Thiazolidinediones | 2016 |
Effect of Chemical Profiling Change of Processed Magnolia officinalis on the Pharmacokinetic Profiling of Honokiol and Magnolol in Rats.
Topics: Alkaloids; Animals; Biphenyl Compounds; Chromatography, Liquid; Cluster Analysis; Drugs, Chinese Herbal; Humans; Lignans; Magnolia; Male; Multivariate Analysis; Plant Stems; Principal Component Analysis; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3β and β-catenin signaling pathway in PC12 cells.
Topics: Amyloid beta-Peptides; Animals; beta Catenin; Biphenyl Compounds; Cell Survival; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Lignans; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Rats; Signal Transduction | 2016 |
Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα.
Topics: Animals; Biphenyl Compounds; Brain; Cell Adhesion; Cells, Cultured; Endothelial Cells; Gene Expression Regulation; Humans; Lignans; Mice; Neutrophils; NF-KappaB Inhibitor alpha; Proteolysis; Tumor Necrosis Factor-alpha; Ubiquitination; Vascular Cell Adhesion Molecule-1 | 2016 |
Regulation of Mucin 1 and multidrug resistance protein 1 by honokiol enhances the efficacy of doxorubicin-mediated growth suppression in mammary carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Breast Neoplasms; Down-Regulation; Doxorubicin; Drug Synergism; Female; Gene Expression; Humans; Lignans; MCF-7 Cells; Mucin-1; Multidrug Resistance-Associated Proteins; RNA, Small Interfering; Transfection | 2016 |
Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.
Topics: Adenine; Animals; Apoptosis; Ascorbic Acid; Autophagy; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Glioma; Lignans; Mice; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2016 |
In vitro antimicrobial activity of honokiol against Staphylococcus aureus in biofilm mode.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Biphenyl Compounds; DNA; Lignans; Molecular Structure; Staphylococcus aureus | 2016 |
c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells.
Topics: Biphenyl Compounds; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Lignans; Male; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Receptors, Androgen; RNA, Messenger | 2016 |
Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Assay; Biphenyl Compounds; Bronchi; Carcinogenesis; Cell Cycle; Cell Proliferation; Cell Survival; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Female; Lignans; Lung Neoplasms; Magnolia; Mice; Molecular Docking Simulation; Nitrosamines; Plant Extracts; RNA, Small Interfering | 2016 |
Synergistic effect of honokiol and 5-fluorouracil on apoptosis of oral squamous cell carcinoma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Synergism; Female; Fluorouracil; Humans; Lignans; Mice; Mice, Inbred BALB C; Mouth Neoplasms | 2017 |
Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Lignans; Lymphoma; Multiple Myeloma; Trityl Compounds | 2016 |
Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Lignans; Lung Neoplasms | 2016 |
Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Communication; Cell Line, Tumor; Down-Regulation; Female; Gene Expression; Hedgehog Proteins; Humans; Lignans; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Pancreatic Neoplasms; Receptors, CXCR4; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2016 |
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions.
Topics: Biphenyl Compounds; Enzyme-Linked Immunosorbent Assay; Gene Expression; HEK293 Cells; HT29 Cells; Humans; Lignans; MCF-7 Cells; Telomerase; Vascular Endothelial Growth Factor A | 2017 |
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Lignans; Lung Neoplasms; Lymphatic Metastasis; Mice; Mice, Inbred NOD; Mice, SCID; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2017 |
Sample injection strategy to increase throughput in counter-current chromatography: Case study of Honokiol purification.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Countercurrent Distribution; Lignans; Magnolia; Plant Extracts; Solvents | 2016 |
Honokiol, a potential therapeutic agent, induces cell cycle arrest and program cell death in vitro and in vivo in human thyroid cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Lignans; Signal Transduction; Thyroid Neoplasms | 2017 |
Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.
Topics: Acetylation; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Core Binding Factor Alpha 2 Subunit; Embryo, Nonmammalian; Humans; Leukemia, Myeloid, Acute; Lignans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Physiologic; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; RUNX1 Translocation Partner 1 Protein; Ubiquitin-Conjugating Enzymes; Zebrafish | 2017 |
Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies.
Topics: Animals; Biphenyl Compounds; Humans; Lignans; Mice; Platelet Aggregation; Protein Binding; Receptors, Collagen; Surface Plasmon Resonance; Thrombosis; Zebrafish | 2017 |
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells.
Topics: Antibiotics, Antineoplastic; Biphenyl Compounds; Bleomycin; Cell Line, Tumor; DNA Polymerase beta; Enzyme Inhibitors; Humans; Kinetics; Lignans | 2017 |
Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction.
Topics: Anti-Infective Agents; Apoptosis; Biphenyl Compounds; Candida albicans; Ditiocarb; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Lignans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Microbial Sensitivity Tests; Microscopy, Fluorescence; Mitochondria; Oxidation-Reduction; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase | 2017 |
Antineoplastic Effects of Honokiol on Melanoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Lignans; Male; Melanoma; Mice; Mice, Nude; Neoplasm Proteins; Xenograft Model Antitumor Assays | 2017 |
Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage.
Topics: Antioxidants; Apoptosis; beta-Galactosidase; Biphenyl Compounds; Cells, Cultured; Cellular Senescence; Fibroblasts; Humans; Inflammation; Interleukin-1alpha; Interleukin-8; Lignans; Tissue Inhibitor of Metalloproteinase-2; Tobacco Smoke Pollution | 2017 |
Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells.
Topics: Animals; Biphenyl Compounds; Carps; Cell Line; Colorimetry; Cytopathogenic Effect, Viral; Fish Diseases; Immunity, Innate; Lignans; Magnolia; Reoviridae; Reoviridae Infections; Tetrazolium Salts; Thiazoles | 2017 |
Enhancing the anti-glioma therapy of doxorubicin by honokiol with biodegradable self-assembling micelles through multiple evaluations.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Liberation; Drug Synergism; Humans; Lignans; Micelles; Nanoparticles; Neovascularization, Pathologic; Polyesters; Polyethylene Glycols; X-Ray Diffraction; Xenograft Model Antitumor Assays; Zebrafish | 2017 |
Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biological Availability; Biphenyl Compounds; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Lignans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Micelles; Nanoparticles; Particle Size; Structure-Activity Relationship; Surface Properties; Triple Negative Breast Neoplasms | 2017 |
Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biocompatible Materials; Biphenyl Compounds; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Drug Liberation; Endocytosis; Female; HEK293 Cells; Humans; Immunohistochemistry; Lignans; Mice, Inbred BALB C; Micelles; Paclitaxel; Particle Size; Polymers | 2017 |
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Topics: Animals; Biphenyl Compounds; Cardiomyopathies; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Doxorubicin; Lignans; Mice; Mitochondria, Heart; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Sirtuin 3; Up-Regulation | 2017 |
Development of a Chitosan-based Nanoparticle Formulation for Ophthalmic Delivery of Honokiol.
Topics: Administration, Ophthalmic; Animals; beta-Cyclodextrins; Biological Availability; Biphenyl Compounds; Chitosan; Drug Delivery Systems; Drug Liberation; Eye; Lignans; Nanoparticles; Particle Size; Rabbits; Surface Properties | 2018 |
SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension.
Topics: Acetylation; Angiotensin II; Animals; Biphenyl Compounds; Disease Models, Animal; Fibrosis; Gene Expression; Gene Expression Regulation; Hypertension, Renal; Kidney; Kruppel-Like Transcription Factors; Lignans; Mice; Mice, Knockout; Models, Biological; Nephritis; Nuclear Proteins; Podocytes; Protein Binding; Signal Transduction; Sirtuin 3 | 2017 |
Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin.
Topics: Animals; Biphenyl Compounds; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dermatitis, Contact; DNA Methylation; Female; Immunosuppression Therapy; Inflammation; Inflammation Mediators; Lignans; Methyltransferases; Mice; Models, Biological; Protective Agents; Proto-Oncogene Proteins; Skin; Ultraviolet Rays | 2017 |
Therapeutic Action of Honokiol on Postoperative Ileus via Downregulation of iNOS Gene Expression.
Topics: Animals; Biphenyl Compounds; Cytokines; Down-Regulation; Gastrointestinal Motility; Ileus; Inflammation Mediators; Leukocytes; Lignans; Macrophages, Peritoneal; Mice; Nitric Oxide Synthase Type II; Postoperative Complications; RNA, Messenger | 2017 |
Transcriptomic analysis of Saccharomyces cerevisiae upon honokiol treatment.
Topics: Antifungal Agents; ATP-Binding Cassette Transporters; Biphenyl Compounds; Down-Regulation; Drug Resistance, Fungal; Gene Expression Profiling; Iron; Lignans; Oligonucleotide Array Sequence Analysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Up-Regulation | 2017 |
Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Female; Humans; Lignans; Mice; Neoplastic Stem Cells; Protein Serine-Threonine Kinases; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2017 |
Antitumor efficacy of Lf modified daunorubicin plus honokiol liposomes in treatment of brain glioma.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Biphenyl Compounds; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Daunorubicin; Drug Liberation; Glioma; Lactoferrin; Lignans; Liposomes; Mice, Inbred ICR; Rats | 2017 |
Plant-derived antifungal compounds trigger a common transcriptional response.
Topics: Antifungal Agents; Biphenyl Compounds; Coumarins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Lignans; Oxidative Stress; Plant Extracts; Resveratrol; Schizosaccharomyces; Stilbenes; Transcription, Genetic; Up-Regulation | 2017 |
Effect of the Biphenyl Neolignan Honokiol on Aβ
Topics: Amyloid beta-Peptides; Animals; Biphenyl Compounds; Caenorhabditis elegans; Catechin; Chelating Agents; Cholinesterase Inhibitors; Drug Stability; Free Radical Scavengers; Humans; Iron; Lignans; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Paralysis; Peptide Fragments; Picrates; Protein Aggregation, Pathological; Protein Multimerization; Resveratrol; Stilbenes | 2017 |
Honokiol attenuates diet-induced non-alcoholic steatohepatitis by regulating macrophage polarization through activating peroxisome proliferator-activated receptor γ.
Topics: Animals; Biphenyl Compounds; Cell Polarity; Diet, High-Fat; Lignans; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; PPAR gamma; RAW 264.7 Cells | 2018 |
Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cerebellum; Female; Glial Fibrillary Acidic Protein; Gliosis; Intermediate Filaments; Lignans; Locomotion; Mice; Mice, Inbred C57BL; Neural Cell Adhesion Molecule L1; Neurons; Recovery of Function; Signal Transduction; Small Molecule Libraries; Spinal Cord Injuries; Trimebutine; Tubulin | 2017 |
Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth.
Topics: Animals; Apoptosis; Biphenyl Compounds; Calcineurin Inhibitors; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Down-Regulation; Heme Oxygenase-1; Hepatocyte Growth Factor; Human Umbilical Vein Endothelial Cells; Humans; Kidney Neoplasms; Lignans; Mice, Nude; Neovascularization, Pathologic; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-met; ras Proteins | 2017 |
BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells.
Topics: Apoptosis; Biphenyl Compounds; Bone Morphogenetic Protein 7; Cell Proliferation; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Lignans; Signal Transduction; Smad Proteins; Tumor Suppressor Protein p53 | 2017 |
Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Brain; Cell Adhesion; Coculture Techniques; Endothelial Cells; Gene Expression Regulation; HEK293 Cells; Humans; Lignans; Magnolia; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophil Activation; Neutrophils; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Receptors, Formyl Peptide; Receptors, Lipoxin; THP-1 Cells | 2017 |
Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with pH-sensitive polymeric micelles.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Lignans; MCF-7 Cells; Neoplasm Metastasis; Paclitaxel | 2017 |
Honokiol Attenuates Oligomeric Amyloid β1-42-Induced Alzheimer's Disease in Mice Through Attenuating Mitochondrial Apoptosis and Inhibiting the Nuclear Factor Kappa-B Signaling Pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hippocampus; Lignans; Male; Maze Learning; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; NF-kappa B; Peptide Fragments; Reactive Oxygen Species; Signal Transduction | 2017 |
Honokiol improved chondrogenesis and suppressed inflammation in human umbilical cord derived mesenchymal stem cells via blocking nuclear factor-κB pathway.
Topics: Anti-Inflammatory Agents; Apoptosis; Biphenyl Compounds; Caspase 3; Cell Differentiation; Cell Survival; Cells, Cultured; Chondrogenesis; Collagenases; Cyclooxygenase 2; Gene Expression Regulation; Humans; Inflammation; Interleukin-6; Lignans; Mesenchymal Stem Cells; NF-kappa B; Signal Transduction | 2017 |
Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans.
Topics: Antifungal Agents; Biphenyl Compounds; Candida albicans; Candidiasis; Electron Transport Complex I; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Lignans; Magnolia; Oxidative Stress; Superoxides | 2017 |
[Pharmacokinetics of magnolol and honokiol in Weichang'an pill].
Topics: Animals; Biphenyl Compounds; Drugs, Chinese Herbal; Lignans | 2016 |
Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts.
Topics: Animals; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; Biphenyl Compounds; Cardiotoxicity; Cell Respiration; Doxorubicin; Heart; Lignans; Mice, Inbred C57BL; Mitochondria; Oxygen | 2017 |
Honokiol triggers receptor‑interacting protein kinase 3‑mediated cell death of neuroblastoma cells by upregulating reactive oxygen species.
Topics: Acetylcysteine; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Silencing; Humans; Lignans; Neuroblastoma; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Time Factors; Up-Regulation | 2017 |
Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biphenyl Compounds; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Inflammation; Lectins, C-Type; Lignans; Lymphocyte Activation; Lymphocyte Count; Male; Mice; Random Allocation; Sepsis; Tumor Necrosis Factor-alpha | 2018 |
Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Proliferation; Cetuximab; Drug Resistance, Neoplasm; Female; Humans; Lignans | 2018 |
H2-P, a honokiol derivative, exerts anti-angiogenesis effects via c-MYC signaling pathway in glioblastoma.
Topics: Angiogenesis Inhibitors; Animals; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chickens; Chorioallantoic Membrane; Female; Glioblastoma; Humans; Lignans; Mice; Proto-Oncogene Proteins c-myc; Rats; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Honokiol exerts dual effects on browning and apoptosis of adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Apoptosis; Biphenyl Compounds; Cell Line; Fluorescent Antibody Technique; Gene Expression Regulation; Lignans; Lipid Metabolism; Mice; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Honokiol protects pancreatic β cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2/ARE pathway in vitro and in vivo.
Topics: Animals; Apoptosis; Biphenyl Compounds; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Free Radical Scavengers; Glucagon; Hypoxia; Insulin; Insulin Resistance; Insulin-Secreting Cells; Lignans; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sleep Apnea, Obstructive | 2018 |
Saccharomyces cerevisiae Hog1 MAP kinase pathway is activated in response to honokiol exposure.
Topics: Biphenyl Compounds; Lignans; Mitogen-Activated Protein Kinases; Mutation; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2018 |
Inhibitory Effects of Honokiol on the Voltage-Gated Potassium Channels in Freshly Isolated Mouse Dorsal Root Ganglion Neurons.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Ganglia, Spinal; Ion Channel Gating; Lignans; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated | 2018 |
Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemoradiotherapy; Down-Regulation; Female; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Lignans; Mice, Nude; Radiation-Sensitizing Agents; Survivin; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Honokiol induces autophagy and apoptosis of osteosarcoma through PI3K/Akt/mTOR signaling pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Humans; Lignans; Osteosarcoma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2018 |
Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Biofilms; Biphenyl Compounds; Humans; Lignans; Microbial Sensitivity Tests; Stomatitis | 2018 |
Local honokiol application inhibits intimal thickening in rabbits following carotid artery balloon injury.
Topics: Animals; Biphenyl Compounds; Carotid Arteries; Carotid Artery Injuries; Cell Proliferation; Collagen; Gene Expression Regulation; Lignans; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Protective Agents; Rabbits; Tissue Inhibitor of Metalloproteinase-1; Tunica Intima | 2018 |
SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway.
Topics: Adenylate Kinase; Amyloid beta-Peptides; Animals; Biphenyl Compounds; CHO Cells; Cricetulus; Cyclic AMP Response Element-Binding Protein; Humans; Lignans; Lipid Peroxidation; Mitochondria; Reactive Oxygen Species; Sirtuin 3 | 2018 |
Hyaluronic acid modified daunorubicin plus honokiol cationic liposomes for the treatment of breast cancer along with the elimination vasculogenic mimicry channels.
Topics: Animals; Biphenyl Compounds; Breast Neoplasms; Cations; Daunorubicin; Female; Humans; Hyaluronic Acid; Lignans; Liposomes; MCF-7 Cells; Mice; Neovascularization, Pathologic | 2018 |
Honokiol Improves Liver Steatosis in Ovariectomized Mice.
Topics: Adiposity; Animals; Biomarkers; Biphenyl Compounds; Body Weight; Cytokines; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Inflammation Mediators; Lignans; Lipid Metabolism; Liver; Mice; Non-alcoholic Fatty Liver Disease; Organ Size; Ovariectomy | 2018 |
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lignans; Macrolides; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Honokiol is a FOXM1 antagonist.
Topics: Animals; Biphenyl Compounds; Cell Line, Tumor; Down-Regulation; Forkhead Box Protein M1; Humans; Lignans; Mice; Proteasome Inhibitors; Transcriptional Activation | 2018 |
Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lignans; MicroRNAs; Osteosarcoma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction | 2018 |
Hyaluronic Acid-Modified Micelles Encapsulating Gem-C
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Drug Compounding; Gemcitabine; Glioblastoma; Humans; Hyaluronan Receptors; Hyaluronic Acid; Lignans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Rats; Rats, Sprague-Dawley; Spheroids, Cellular; Survival Rate; Treatment Outcome; Xenograft Model Antitumor Assays | 2018 |
Oligochitosan-pluronic 127 conjugate for delivery of honokiol.
Topics: Animals; Antifungal Agents; Biological Transport; Biphenyl Compounds; Candida albicans; Cell Line; Chitin; Chitosan; Drug Carriers; Drug Liberation; Hemolysis; Lignans; Materials Testing; Micelles; Oligosaccharides; Poloxamer; Rats; Solubility; Solvents; Volatilization | 2018 |
Design, synthesis and antibacterial evaluation of honokiol derivatives.
Topics: Anti-Bacterial Agents; Biphenyl Compounds; Cell Wall; Cyclization; Drug Design; Escherichia coli; Kinetics; Lignans; Linezolid; Microbial Sensitivity Tests; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin | 2018 |
Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Biphenyl Compounds; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Enzyme Activation; Fibroblasts; Humans; Lignans; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Osteosarcoma; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2018 |
Synthesis of magnolol and honokiol derivatives and their effect against hepatocarcinoma cells.
Topics: Biphenyl Compounds; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lignans; Liver Neoplasms; Proton Magnetic Resonance Spectroscopy | 2018 |
Simultaneous determination of Magnolol and Honokiol by amino acid ionic liquid synchronous fluorescence spectrometry.
Topics: Amino Acids; Biphenyl Compounds; Hydrogen-Ion Concentration; Imidazoles; Ionic Liquids; Lignans; Limit of Detection; Linear Models; Models, Molecular; Reproducibility of Results; Spectrometry, Fluorescence; Temperature | 2018 |
Identification, characterization and HPLC quantification of formulation-related impurities of honokiol, an antitumor natural drug candidate in clinical trials.
Topics: Antineoplastic Agents; Biological Products; Biphenyl Compounds; China; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Contamination; Drugs, Chinese Herbal; Lignans; Magnetic Resonance Spectroscopy; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
Effects of Honokiol on CYP450 Activity and Transporter mRNA Expression in Type 2 Diabetic Rats.
Topics: Animals; Anion Transport Proteins; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastrointestinal Agents; Kidney; Lignans; Liver; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2018 |
Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Humans; Lignans; Temozolomide | 2018 |
Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carrier Proteins; Cell Cycle Proteins; Inflammasomes; Intervertebral Disc Degeneration; Lignans; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleus Pulposus; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Acute and subchronic toxicities in dogs and genotoxicity of honokiol microemulsion.
Topics: Animals; Biphenyl Compounds; Dogs; Emulsions; Female; Lignans; Male; Mice, Inbred ICR; Mutagenicity Tests; No-Observed-Adverse-Effect Level; Toxicity Tests, Acute; Toxicity Tests, Subchronic | 2018 |
Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway.
Topics: Animals; Apoptosis; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Echocardiography; In Situ Nick-End Labeling; Lignans; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Rats; Signal Transduction; Sirtuin 1; Superoxide Dismutase | 2018 |
Honokiol nanoparticles based on epigallocatechin gallate functionalized chitin to enhance therapeutic effects against liver cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Hepatocellular; Catechin; Cell Proliferation; Chitin; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Liberation; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Kinetics; Lignans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Nanoparticles; Nanotechnology; Particle Size; Solubility; Surface Properties; Technology, Pharmaceutical; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
[Inhibition of methicillin-resistant Staphylococcus aureus biofilm by honokiol].
Topics: Anti-Bacterial Agents; Biofilms; Biphenyl Compounds; Drugs, Chinese Herbal; Humans; Lignans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Staphylococcal Infections | 2016 |
Synergistically Enhanced Antimetastasis Effects by Honokiol-Loaded pH-Sensitive Polymer-Doxorubicin Conjugate Micelles.
Topics: Animals; Biphenyl Compounds; Cell Line, Tumor; Doxorubicin; Drug Carriers; Humans; Hydrogen-Ion Concentration; Lignans; Mice; Mice, Nude; Micelles; Polymers | 2018 |
Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity.
Topics: Administration, Oral; Animals; Apoptosis; Biphenyl Compounds; Cytokines; Enterotoxigenic Escherichia coli; Homeostasis; Inflammation Mediators; Intestinal Absorption; Intestinal Mucosa; Lignans; Mice; Nitric Oxide Synthase | 2018 |
Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus-Pituitary-Adrenal Axis Activity.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Chronic Disease; Dose-Response Relationship, Drug; Hippocampus; Hypothalamo-Hypophyseal System; Lignans; Male; Pituitary-Adrenal System; Rats; Rats, Wistar; Stress, Psychological; Treatment Outcome | 2018 |
Honokiol Alleviates Cognitive Deficits of Alzheimer's Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Biphenyl Compounds; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Female; Hippocampus; Lignans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Neurons; Oligoribonucleotides; Oxidative Stress; Presenilin-1; Rats; Rats, Sprague-Dawley; Sirtuin 3 | 2018 |
Proteomic analysis of honokiol-induced cytotoxicity in thyroid cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lignans; Magnolia; Mass Spectrometry; Neoplasm Metastasis; Plant Extracts; Protein Processing, Post-Translational; Proteome; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thyroid Neoplasms | 2018 |
Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson's disease.
Topics: Animals; Apomorphine; Biphenyl Compounds; Corpus Striatum; Disease Models, Animal; Lignans; Male; Mice; Microinjections; Motor Activity; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidopamine; Parkinson Disease, Secondary; Postural Balance; Substantia Nigra; Tyrosine 3-Monooxygenase | 2018 |
Roles of the Hsp90-Calcineurin Pathway in the Antifungal Activity of Honokiol.
Topics: Antifungal Agents; Apoptosis; Biphenyl Compounds; Calcineurin; Calcineurin Inhibitors; Candida albicans; Cyclosporine; HSP90 Heat-Shock Proteins; Lignans; Magnolia; Microbial Sensitivity Tests; Mitochondria | 2018 |
Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo.
Topics: Administration, Intravenous; Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diclofenac; Drug Interactions; Gene Expression Regulation; Lignans; Liver; Microsomes, Liver; Molecular Structure; Phenacetin; Rats; Rats, Sprague-Dawley | 2018 |
Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.
Topics: Adrenergic Agents; Animals; Apoptosis; Biphenyl Compounds; Glutathione; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Lignans; NAD(P)H Dehydrogenase (Quinone); Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Oxidopamine; PC12 Cells; Rats; Thioredoxin Reductase 1; Thioredoxins | 2018 |
Oral administration of honokiol attenuates airway inflammation in asthmatic mouse model.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Asthma; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Lignans; Mice, Inbred BALB C; Respiratory System | 2018 |
Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3.
Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Line; Cytoprotection; Enzyme Activation; Hepatocytes; Lignans; Mice; Mitochondria; Oxidative Stress; Protein Serine-Threonine Kinases; Signal Transduction; Sirtuin 3 | 2018 |
Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells.
Topics: Anti-Inflammatory Agents; Biphenyl Compounds; Chemokine CXCL10; Chemokine CXCL11; Epithelial Cells; Humans; Interleukin-27; Ligands; Lignans; Mouth; Periodontal Diseases; Proto-Oncogene Proteins c-akt; Receptors, CXCR3; STAT3 Transcription Factor | 2018 |
Self-Assembled Honokiol-Loaded Microbubbles in the Treatment of Ovarian Cancer by Ultrasound Irradiation.
Topics: Animals; Biphenyl Compounds; Female; Humans; Lignans; Mice; Mice, Nude; Microbubbles; Ovarian Neoplasms; Particle Size; Polyesters; Polyethylene Glycols; Ultrasonic Waves | 2018 |
Functional paclitaxel plus honokiol micelles destroying tumour metastasis in treatment of non-small-cell lung cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; Cell Survival; Dequalinium; Drug Interactions; Drug Liberation; Humans; Lignans; Lung Neoplasms; Mice; Micelles; Neoplasm Metastasis; Paclitaxel; Temperature; Xenograft Model Antitumor Assays | 2018 |
Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Humans; Interleukin-6; Lignans; Mouth Neoplasms; Neoplastic Stem Cells; Signal Transduction; STAT3 Transcription Factor | 2018 |
Genome-wide screening of budding yeast with honokiol to associate mitochondrial function with lipid metabolism.
Topics: ATP-Binding Cassette Transporters; Biphenyl Compounds; Drug Resistance; Enzyme Inhibitors; Genes, Fungal; Lignans; Lipid Metabolism; Mitochondria; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2018 |
[Effects of honokiol on particulate matter 2.5-induced lung injury in asthmatic mice and its mechanisms].
Topics: Animals; Asthma; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation Mediators; Lignans; Lung; Lung Injury; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Particulate Matter; Random Allocation; Toll-Like Receptor 4 | 2018 |
Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis.
Topics: AMP-Activated Protein Kinase Kinases; Angiopoietin-2; Animals; Apoptosis; Biphenyl Compounds; Capillary Permeability; Case-Control Studies; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Humans; Lignans; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Protein Kinases; Respiratory Distress Syndrome; Signal Transduction; Sirtuin 3 | 2018 |
Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Biphenyl Compounds; Cells, Cultured; Inflammation Mediators; Kruppel-Like Factor 4; Lignans; Lipopolysaccharides; Microglia; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2018 |
Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium.
Topics: Anti-Inflammatory Agents; Biphenyl Compounds; Chemokine CCL2; Chemokine CXCL1; Dinoprost; Dinoprostone; Extraembryonic Membranes; Female; Humans; Interleukin-1beta; Interleukin-8; Lignans; Myometrium; Pregnancy; Premature Birth; Primary Cell Culture; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2018 |
Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway.
Topics: Animals; Apoptosis; Biphenyl Compounds; Caspases; Cell Line, Tumor; Cell Survival; Cytochromes c; Dacarbazine; DNA Fragmentation; Drugs, Chinese Herbal; Fas Ligand Protein; Glioma; Humans; Lignans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Reactive Oxygen Species; Signal Transduction; Temozolomide | 2018 |
Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation.
Topics: Animals; Biphenyl Compounds; Gliosis; Lignans; Longevity; Male; Mice; Motor Activity; NADPH Oxidases; Neostriatum; Nerve Degeneration; Oxidation-Reduction; Oxidopamine; Parkinson Disease; PPAR gamma | 2018 |
Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique, characterization, pharmacokinetics, and evaluation of inhibitory effect on HepG2 cells.
Topics: Administration, Oral; Animals; Biological Availability; Biphenyl Compounds; Calorimetry, Differential Scanning; Chemical Precipitation; Female; Hep G2 Cells; Humans; Lignans; Nanoparticles; Organ Specificity; Particle Size; Rats, Sprague-Dawley; Solubility; Solvents; Thermogravimetry; Toxicity Tests; X-Ray Diffraction | 2018 |
Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter.
Topics: Adrenergic Neurons; Anti-Anxiety Agents; Benzhydryl Compounds; Biphenyl Compounds; Central Nervous System; HEK293 Cells; Humans; Lignans; Magnolia; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Plant Bark; Plant Extracts; Receptors, GABA-A | 2018 |
SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cognitive Dysfunction; Female; Hippocampus; Inflammation; Laparotomy; Lignans; Mice, Inbred C57BL; Nootropic Agents; Oxidative Stress; Postoperative Complications; Random Allocation; Sevoflurane; Sirtuin 3 | 2019 |
[Study on effect and mechanism of Honokiol enhancing tumor necrosis factor-related apoptosis inducing ligand against hepatocellular carcinoma HepG2 cells via activating JNK signaling pathway].
Topics: Animals; Apoptosis; Biphenyl Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Nude; TNF-Related Apoptosis-Inducing Ligand | 2018 |
In vitro metabolism of magnolol and honokiol in rat liver microsomes and their interactions with seven cytochrome P substrates.
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Inhibitory Concentration 50; Lignans; Male; Mass Spectrometry; Microsomes, Liver; Rats, Sprague-Dawley; Substrate Specificity | 2019 |
Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways.
Topics: Animals; Antineoplastic Agents, Phytogenic; beta Catenin; Biphenyl Compounds; Calpain; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase 2; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Lignans; Male; Melanoma; Mice, Inbred BALB C; Mice, Nude; Microphthalmia-Associated Transcription Factor; Peritoneal Neoplasms; Skin Neoplasms; Transcription Factor CHOP; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2019 |
Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cells, Cultured; Female; Humans; Intervertebral Disc Degeneration; Lignans; Male; Middle Aged; Mitochondrial Dynamics; Nucleus Pulposus; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sirtuin 3 | 2018 |
How changes in column geometry and packing ratio can increase sample load and throughput by a factor of fifty in Counter-Current Chromatography.
Topics: Biphenyl Compounds; Chemistry, Pharmaceutical; Countercurrent Distribution; Hexanes; Lignans; Methanol; Solvents; Water | 2018 |
Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Biphenyl Compounds; Cell Line; Dose-Response Relationship, Drug; Heterocyclic Compounds; Lignans; Lipopolysaccharides; Mice; Molecular Structure; Nitric Oxide; Structure-Activity Relationship | 2019 |
Honokiol induces apoptosis of lung squamous cell carcinoma by targeting FGF2-FGFR1 autocrine loop.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Fibroblast Growth Factor 2; Humans; Lignans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Receptor, Fibroblast Growth Factor, Type 1 | 2018 |
[Honokiol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via activation of mitochondrion-dependent Sirt3/AMPK pathway].
Topics: Acute Lung Injury; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Humans; Lignans; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Mitochondria; Signal Transduction; Sirtuin 3 | 2018 |
Design, synthesis and biological evaluation of honokiol derivatives as influenza neuraminidase inhibitors.
Topics: Antiviral Agents; Biphenyl Compounds; Drug Design; Humans; Influenza, Human; Lignans; Molecular Structure; Neuraminidase | 2019 |
Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep.
Topics: Administration, Oral; Animals; Benzodiazepines; Biphenyl Compounds; Drug Carriers; Electroencephalography; Eye Movements; Female; Lignans; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep, Slow-Wave | 2019 |
Honokiol Attenuates Sepsis-Associated Acute Kidney Injury via the Inhibition of Oxidative Stress and Inflammation.
Topics: Acute Kidney Injury; Animals; Anti-Infective Agents; Biphenyl Compounds; Cell Line; Inflammation; Lignans; Oxidative Stress; Rats; Sepsis | 2019 |
Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Breast Neoplasms; Cell Proliferation; Drug Carriers; Drug Screening Assays, Antitumor; Female; Folic Acid; Hydrogen-Ion Concentration; Indoles; Lignans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Optical Imaging; Particle Size; Polymers; Surface Properties | 2019 |
Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells.
Topics: A549 Cells; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Movement; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Lignans; Lung Neoplasms; RNA, Small Interfering; Signal Transduction; Transcription Factor CHOP | 2019 |
The effect of honokiol on pulmonary artery endothelium cell autophagy mediated by cyclophilin A in hypoxic pulmonary arterial hypertension.
Topics: Animals; Autophagy; Biphenyl Compounds; Blotting, Western; Cattle; Cells, Cultured; Cyclophilin A; Endothelial Cells; Endothelium, Vascular; Hypertension, Pulmonary; Lignans; Male; Microscopy, Fluorescence; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2019 |
Formylated honokiol analogs showed antitumor activity against lung carcinoma.
Topics: Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Lewis Lung; Cell Proliferation; Female; Formates; Humans; Lignans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway.
Topics: Acute Kidney Injury; Animals; Biphenyl Compounds; Disease Models, Animal; Heme Oxygenase-1; Kidney; Lignans; Male; Mice; MicroRNAs; Protective Agents; Sepsis; Signal Transduction | 2019 |
Expression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: a biochemical and immunohistochemical study.
Topics: Animals; Biphenyl Compounds; Blood-Brain Barrier; Brain Injuries, Traumatic; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutathione Peroxidase; Immunohistochemistry; Lignans; Male; Malondialdehyde; Permeability; Peroxidase; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2019 |
Comparison of the GPVI inhibitors losartan and honokiol.
Topics: Biphenyl Compounds; Blood Platelets; Collagen; Humans; Lectins, C-Type; Lignans; Losartan; Membrane Glycoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Platelet-Rich Plasma; Receptors, IgG; Syk Kinase; Thrombosis | 2020 |
Honokiol induces apoptosis and suppresses migration and invasion of ovarian carcinoma cells via AMPK/mTOR signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Enzyme Activation; Female; Humans; Lignans; Mice; Models, Biological; Neoplasm Invasiveness; NIH 3T3 Cells; Ovarian Neoplasms; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay | 2019 |
Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol.
Topics: Acyclovir; Animals; Antiviral Agents; Biphenyl Compounds; Chlorocebus aethiops; DNA Replication; Genome, Viral; Herpesvirus 1, Human; Lignans; Magnolia; Mice; Mice, Inbred C57BL; Phytochemicals; Vero Cells; Virus Replication | 2019 |
Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Cognitive Dysfunction; Dentate Gyrus; Female; Hippocampus; Inflammasomes; Lignans; Mice, Inbred C57BL; Microglia; Mitochondria; Mitophagy; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Postoperative Complications; Reactive Oxygen Species; Sevoflurane | 2019 |
Identification of minor lignans, alkaloids, and phenylpropanoid glycosides in Magnolia officinalis by HPLC‒DAD‒QTOF-MS/MS.
Topics: Alkaloids; Aporphines; Biphenyl Compounds; Chromatography, High Pressure Liquid; Glucosides; Glycosides; Isoquinolines; Lignans; Magnolia; Methanol; Phenols; Propanols; Tandem Mass Spectrometry | 2019 |
Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3
Topics: Analgesics; Animals; Biphenyl Compounds; Burns; Cytokines; Edema; Hyperalgesia; Inflammation; Inflammation Mediators; Interleukin-1beta; Lignans; Magnolia; Male; Mice; Mice, Inbred BALB C; Pain; Receptors, Purinergic P2Y; Signal Transduction; Spinal Cord; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2019 |
Opposite effects of vitamin C and vitamin E on the antifungal activity of honokiol.
Topics: Antifungal Agents; Antioxidants; Ascorbic Acid; Biphenyl Compounds; Candida albicans; DNA, Mitochondrial; Drug Antagonism; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Lignans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Microbial Sensitivity Tests; Mitochondria; Reactive Oxygen Species; Vitamin E | 2019 |
Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish.
Topics: Animals; Antioxidants; Biphenyl Compounds; Catalase; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heme Oxygenase-1; Lethal Dose 50; Lignans; Locomotion; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Swimming; Zebrafish; Zebrafish Proteins | 2019 |
Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury by enhancing autophagic flux and reducing intracellular ROS production.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Chloroquine; Disease Models, Animal; Lignans; Male; Mice; Mice, Inbred C57BL; Mitochondria; Myocardial Reperfusion Injury; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Signal Transduction | 2019 |
Honokiol Induces Autophagic Apoptosis in Neuroblastoma Cells through a P53-Dependent Pathway.
Topics: Apoptosis; Autophagy; Biphenyl Compounds; Caspase 3; Cell Survival; Humans; Lignans; Neuroblastoma; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2019 |
Subinhibitory concentrations of Honokiol reduce α-Hemolysin (Hla) secretion by
Topics: A549 Cells; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacterial Toxins; Biphenyl Compounds; Cell Survival; Disease Models, Animal; Hemolysin Proteins; Histocytochemistry; Humans; Inflammasomes; Lignans; Liver; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Receptors, Cell Surface; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2019 |
Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Glutathione; Lignans; Liver; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Signal Transduction | 2019 |
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model.
Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Biphenyl Compounds; Brain; Calcium; Cytokines; Depression; Disease Models, Animal; Hindlimb Suspension; Immobilization; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Lignans; Lipopolysaccharides; Mice, Inbred ICR; NF-kappa B; RNA, Messenger; Swimming; Tryptophan | 2019 |
Antifungal Effect of Magnolol and Honokiol from
Topics: Alternaria; Antifungal Agents; Biphenyl Compounds; Lignans; Magnolia; Nicotiana; Plant Diseases | 2019 |
Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer.
Topics: A549 Cells; Apoptosis; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lignans; Lung Neoplasms; MicroRNAs; Principal Component Analysis; RNA, Messenger | 2019 |
Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Humans; Lignans; Lung Neoplasms; Mice, Inbred BALB C; Snail Family Transcription Factors | 2019 |
Synthesis of Either C2- or C4'-Alkylated Derivatives of Honokiol and Their Biological Evaluation for Anti-inflammatory Activity.
Topics: Alkylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Inflammation; Lignans; Lipopolysaccharides; Mice; Molecular Structure; Nitric Oxide; RAW 264.7 Cells; Stereoisomerism | 2019 |
Anti-proliferative activity and structure-activity relationship of honokiol derivatives.
Topics: Biphenyl Compounds; Humans; Lignans; Structure-Activity Relationship | 2019 |
Honokiol Attenuates the Memory Impairments, Oxidative Stress, Neuroinflammation, and GSK-3β Activation in Vascular Dementia Rats.
Topics: Animals; Biphenyl Compounds; Brain; Dementia, Vascular; Disease Models, Animal; Enzyme Activation; Glycogen Synthase Kinase 3 beta; Inflammation; Lignans; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2019 |
Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns.
Topics: Bile Duct Neoplasms; Biphenyl Compounds; Cancer Vaccines; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Dendritic Cells; Healthy Volunteers; Humans; Immunogenicity, Vaccine; Immunotherapy; Lignans; Lymphocyte Activation; T-Lymphocytes, Cytotoxic; Transplantation, Autologous | 2019 |
Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance.
Topics: Antifungal Agents; Biphenyl Compounds; Fusariosis; Fusarium; Humans; Lignans; Microbial Sensitivity Tests; Plant Diseases | 2019 |
Neuraminidase 1 regulates proliferation, apoptosis and the expression of Cadherins in mammary carcinoma cells.
Topics: Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Proliferation; Female; Humans; Lignans; N-Acetylneuraminic Acid; Neuraminidase | 2019 |
A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism.
Topics: Anti-Bacterial Agents; Bacterial Outer Membrane; Biofilms; Biphenyl Compounds; Cetylpyridinium; Lignans; Microbial Sensitivity Tests; Microbiota; Phenols; Streptococcus mutans | 2020 |
Magnolol protects PC12 cells from hydrogen peroxide or 6-hydroxydopamine induced cytotoxicity.
Topics: Animals; Biphenyl Compounds; Catalase; Cell Death; Cell Survival; Hydrogen Peroxide; Lignans; NAD(P)H Dehydrogenase (Quinone); Oxidopamine; PC12 Cells; Protective Agents; Rats | 2019 |
Honokiol antagonizes doxorubicin‑induced cardiomyocyte senescence by inhibiting TXNIP‑mediated NLRP3 inflammasome activation.
Topics: Biphenyl Compounds; Carrier Proteins; Cell Line; Cell Survival; Cellular Senescence; Doxorubicin; Drug Antagonism; Humans; Inflammasomes; Lignans; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress | 2020 |
Mechanistic aspects of antifibrotic effects of honokiol in Con A-induced liver fibrosis in rats: Emphasis on TGF-β/SMAD/MAPK signaling pathways.
Topics: Actins; Animals; Biphenyl Compounds; Concanavalin A; Hydroxyproline; Inflammation; Lignans; Liver Cirrhosis; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Survival Analysis; Transforming Growth Factor beta | 2020 |
Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lignans; Peptide Hydrolases; Plant Extracts; Survivin; TNF-Related Apoptosis-Inducing Ligand; Ubiquitination | 2019 |
Synthesis and in vitro antitumor evaluation of honokiol derivatives.
Topics: Antineoplastic Agents; Biphenyl Compounds; Humans; Lignans; Neoplasms | 2020 |
Honokiol Restores Polymyxin Susceptibility to MCR-1-Positive Pathogens both
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Biphenyl Compounds; Colistin; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Female; Lignans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Polymyxins | 2020 |
A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.
Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Betulinic Acid; Biphenyl Compounds; Cell Proliferation; Cisplatin; Ginsenosides; Humans; Lignans; Liposomes; Lung Neoplasms; Mice; Neoplasm Invasiveness; Pentacyclic Triterpenes; Sesquiterpenes; Triterpenes; Xenograft Model Antitumor Assays | 2020 |
Preparation and Characterization of Honokiol Nanosuspensions and Preliminary Evaluation of Anti-Inflammatory Effect.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Female; Lignans; Male; Mice; Nanoparticles; Solubility; Suspensions | 2020 |
Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κBTGF-β1/Smad Signaling Pathway.
Topics: Animals; Biphenyl Compounds; Cell Line; Disease Models, Animal; Fibrosis; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Kidney Diseases; Lignans; Mice; Mitochondrial Dynamics; NF-kappa B; Signal Transduction; Sirtuin 3; Smad Proteins; Transforming Growth Factor beta1 | 2020 |
Honokiol suppresses mycelial growth and reduces virulence of Botrytis cinerea by inducing autophagic activities and apoptosis.
Topics: Antifungal Agents; Apoptosis; Autophagy; Biphenyl Compounds; Botrytis; Down-Regulation; Fruit; Genes, Fungal; Lignans; Magnolia; Membrane Potential, Mitochondrial; Mycelium; Plant Diseases; Reactive Oxygen Species; Virulence | 2020 |
Overcoming acquired resistance of EGFR-mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib, with the natural product honokiol.
Topics: Acrylamides; Aniline Compounds; Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Humans; Lignans; Lung Neoplasms; Mice, Nude; Mutation; Protein Kinase Inhibitors | 2020 |
Development of Nanosome-Encapsulated Honokiol for Intravenous Therapy Against Experimental Autoimmune Encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental; Female; Injections, Intravenous; Lignans; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelitis; Nanostructures; Neuroprotective Agents; Spinal Cord; Th1 Cells | 2020 |
Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-β/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.
Topics: Animals; Biphenyl Compounds; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Line; Cell Movement; Collagen; Cytokines; Epithelial-Mesenchymal Transition; Humans; Hyaluronan Receptors; Interleukin-6; Lignans; Lung; Mice; Pulmonary Fibrosis; Signal Transduction; Smad Proteins; STAT3 Transcription Factor; Transforming Growth Factor beta | 2020 |
Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance.
Topics: Adult; Aged; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biphenyl Compounds; Brain; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Chitinase-3-Like Protein 1; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Male; Middle Aged; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Pathologic; Tumor Microenvironment; Up-Regulation; Xenograft Model Antitumor Assays; Young Adult; Zinc Finger E-box-Binding Homeobox 1 | 2020 |
Synthesis of Bisphenol Neolignans Inspired by Honokiol as Antiproliferative Agents.
Topics: Antineoplastic Agents; Apoptosis; Benzhydryl Compounds; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HCT116 Cells; HT29 Cells; Humans; Lignans; PC-3 Cells; Phenols | 2020 |
Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine:
Topics: Animals; Anticonvulsants; Biphenyl Compounds; Epilepsy; Lignans; Magnolia; Medicine, Chinese Traditional; Mice; Plant Extracts; Zebrafish | 2020 |
Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast Neoplasms; Celecoxib; Lignans; Mice; Mice, Inbred BALB C; Polyesters; Polyethylene Glycols; Vitamin E | 2020 |
Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol.
Topics: Animals; Biological Availability; Biphenyl Compounds; Caco-2 Cells; Carbon Dioxide; Drug Delivery Systems; Fluorescent Dyes; gamma-Cyclodextrins; Humans; Hydrogen-Ion Concentration; Lignans; Male; Metal-Organic Frameworks; Molecular Structure; Optical Imaging; Particle Size; Rats; Rats, Sprague-Dawley; Solubility; Surface Properties; Tumor Cells, Cultured | 2020 |
Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis.
Topics: Animals; Benzoxazoles; Biphenyl Compounds; Insecticides; Larva; Lignans; Magnolia; Models, Molecular; Molecular Structure; Moths; Plant Bark; Plant Stems | 2020 |
Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells.
Topics: Apoptosis; Biphenyl Compounds; Caspase 9; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Glioblastoma; Humans; Lignans; Mitochondria; Neoplasm Proteins; Temozolomide | 2020 |
Design, Formulation and in vivo Evaluation of Novel Honokiol-Loaded PEGylated PLGA Nanocapsules for Treatment of Breast Cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Drug Delivery Systems; Female; Humans; Lignans; MCF-7 Cells; Mice; Micelles; Nanocapsules; Polyethylene Glycols; Polyglactin 910; Solubility; Xenograft Model Antitumor Assays | 2020 |
Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Humans; Lignans; Magnolia; Mice; Mice, Nude; Mitochondria; Mouth Neoplasms; Plant Extracts; Reactive Oxygen Species | 2020 |
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Topics: Acetylation; Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cisplatin; Fatty Acids; Fatty Acids, Nonesterified; Kidney Function Tests; Lignans; Lipid Metabolism; Lipid Peroxidation; Lipids; Male; Metabolomics; Mice; Mice, Knockout; Mitochondria; Phosphorylation; Prognosis; Reactive Oxygen Species; Sirtuin 3 | 2020 |
Honokiol Reduces Fungal Load, Toll-Like Receptor-2, and Inflammatory Cytokines in Aspergillus fumigatus Keratitis.
Topics: Animals; Anti-Infective Agents; Aspergillosis; Aspergillus fumigatus; Biphenyl Compounds; Blotting, Western; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Infections, Fungal; Female; Keratitis; Lignans; Mice; Mice, Inbred C57BL; Random Allocation; Real-Time Polymerase Chain Reaction; Toll-Like Receptor 2; Treatment Outcome | 2020 |
Honokiol inhibits carotid artery atherosclerotic plaque formation by suppressing inflammation and oxidative stress.
Topics: Animals; Atherosclerosis; Biphenyl Compounds; Carotid Arteries; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Inflammation; Lignans; Male; Mice; Oxidative Stress; Plaque, Atherosclerotic; Signal Transduction | 2020 |
Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1.
Topics: Allosteric Regulation; Antineoplastic Agents; Biphenyl Compounds; Cell Line; HSP90 Heat-Shock Proteins; Humans; Lignans; Mitochondria; Models, Molecular; Molecular Structure; Recombinant Proteins | 2021 |
Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes.
Topics: Albuminuria; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Kidney Glomerulus; Lignans; Male; Mice; Mice, Obese; Mitochondria; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Podocytes; Reactive Oxygen Species; Sirtuin 3; Superoxide Dismutase | 2020 |
Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction.
Topics: Algorithms; Animals; Anthraquinones; Biomarkers, Pharmacological; Biphenyl Compounds; Data Mining; Drugs, Chinese Herbal; Flavanones; HT29 Cells; Humans; Intestinal Obstruction; Lignans; Male; Phosphatidylinositol 3-Kinases; Rats, Sprague-Dawley; Reproducibility of Results; Therapeutic Equivalency | 2020 |
Targeted delivery of honokiol by zein/hyaluronic acid core-shell nanoparticles to suppress breast cancer growth and metastasis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cell Movement; Cell Proliferation; Drug Carriers; Drug Screening Assays, Antitumor; Female; Hyaluronic Acid; Lignans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Tumor Cells, Cultured; Zein | 2020 |
Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway.
Topics: AMP-Activated Protein Kinases; Biphenyl Compounds; Chagas Disease; Humans; Lignans; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Sirtuin 3 | 2020 |
Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from
Topics: Animals; Biphenyl Compounds; Cell Line; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lignans; Magnolia; Membrane Potentials; Patch-Clamp Techniques; Plant Extracts; Rats | 2020 |
Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations.
Topics: Biphenyl Compounds; Chromatography, Thin Layer; Densitometry; Dietary Supplements; Lignans; Limit of Detection; Magnolia; Medicine, East Asian Traditional; Plant Bark | 2020 |
Preparation of restricted access monolithic tip via unidirectional freezing and atom transfer radical polymerization for directly extracting magnolol and honokiol from rat plasma followed by liquid chromatography analysis.
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Freezing; Hydrophobic and Hydrophilic Interactions; Lignans; Methacrylates; Polyethylene Glycols; Quality Control; Rats; Reproducibility of Results; Solid Phase Extraction | 2020 |
Honokiol ameliorates angiotensin II-induced hypertension and endothelial dysfunction by inhibiting HDAC6-mediated cystathionine γ-lyase degradation.
Topics: Acetylation; Angiotensin II; Animals; Aorta; Biphenyl Compounds; Cystathionine gamma-Lyase; Endothelial Cells; HEK293 Cells; Histone Deacetylase 6; Humans; Hydrogen Sulfide; Hypertension; Lignans; Male; Mice; Mice, Inbred C57BL; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Proteolysis; Recombinant Proteins | 2020 |
3D-Printed Extracellular Matrix/Polyethylene Glycol Diacrylate Hydrogel Incorporating the Anti-inflammatory Phytomolecule Honokiol for Regeneration of Osteochondral Defects.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cartilage, Articular; Extracellular Matrix; Hydrogels; Lignans; Osteoarthritis; Polyethylene Glycols; Printing, Three-Dimensional; Rats; Rats, Sprague-Dawley; Regeneration; Tissue Scaffolds | 2020 |
Apoptotic and antihepatofibrotic effect of honokiol via activation of GSK3β and suppression of Wnt/β-catenin pathway in hepatic stellate cells.
Topics: Actins; beta Catenin; Biphenyl Compounds; Caspase 3; Cell Line; Cyclin D1; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Hepatic Stellate Cells; Humans; Lignans; Liver Cirrhosis; Phosphorylation; Smad3 Protein; Transforming Growth Factor beta1; Wnt Signaling Pathway | 2021 |
Evaluation of anticancer activity of honokiol by complexation with hydroxypropyl-β-cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Biphenyl Compounds; Humans; Lignans; Solubility | 2020 |
Honokiol-mesoporous Silica Nanoparticles Inhibit Vascular Restenosis via the Suppression of TGF-β Signaling Pathway.
Topics: Animals; Biphenyl Compounds; Carotid Artery Injuries; Cell Line; Cell Proliferation; Coronary Restenosis; Disease Models, Animal; Drug Delivery Systems; Humans; Lignans; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Percutaneous Coronary Intervention; Poloxamer; Rats, Sprague-Dawley; Silicon Dioxide | 2020 |
Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Biphenyl Compounds; Cells, Cultured; Female; Inflammasomes; Kidney; Lignans; Lupus Nephritis; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Sirtuin 1; T-Lymphocytes | 2020 |
Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Carbon; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Breaks, Double-Stranded; G2 Phase Cell Cycle Checkpoints; Humans; Ions; Lignans; Linear Energy Transfer; Lung Neoplasms; Protein Kinase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; Thiophenes; Tunicamycin; Urea; X-Rays | 2020 |
Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism.
Topics: Apoptosis; Biphenyl Compounds; Case-Control Studies; Cell Proliferation; Humans; Lignans; Matrix Metalloproteinase 9; Phosphatidylinositol 3-Kinase; Receptor, ErbB-2; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured | 2020 |
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.
Topics: Acetylation; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Energy Metabolism; Heart Diseases; Lignans; Male; Mitochondria, Heart; Myocardium; Phosphocreatine; Rats; Rats, Wistar | 2020 |
[Effect of honokiol on proliferation, migration and apoptosis of human tongue cancer CAL-27 cells
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Humans; Lignans; Tongue Neoplasms | 2020 |
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Bone Morphogenetic Protein 7; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Female; Humans; Lignans; Mice; Mice, Nude; Signal Transduction; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2020 |
Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction.
Topics: Animals; Apoptosis; Biphenyl Compounds; Calcium; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Lignans; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Mitochondria; Paclitaxel; Proteasome Endopeptidase Complex; Ubiquitin-Activating Enzymes; Vacuoles | 2021 |
Novel nanomicelles based on rebaudioside A: A potential nanoplatform for oral delivery of honokiol with enhanced oral bioavailability and antitumor activity.
Topics: Animals; Biological Availability; Biphenyl Compounds; Diterpenes, Kaurane; Drug Delivery Systems; Lignans; Mice; Micelles; Rats | 2020 |
In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages.
Topics: Animals; Anti-Bacterial Agents; Biphenyl Compounds; Humans; Inflammation; Lignans; Macrophages | 2021 |
Bioassay-guided isolation of two antifungal compounds from Magnolia officinalis, and the mechanism of action of honokiol.
Topics: Antifungal Agents; Biological Assay; Biphenyl Compounds; Lignans; Magnolia | 2020 |
Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine.
Topics: Antineoplastic Agents; Apoptosis; Berberine; Biphenyl Compounds; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lignans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Reactive Oxygen Species; Structure-Activity Relationship | 2020 |
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Animal; Hippocampus; Lignans; Male; Mineralocorticoids; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger | 2020 |
Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants.
Topics: Adjuvants, Immunologic; Animals; Biphenyl Compounds; Lignans; Mice; NF-kappa B; RAW 264.7 Cells; Vaccines | 2020 |
Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3.
Topics: Animals; Biphenyl Compounds; Brain; Brain Injuries; Lignans; Oxidative Stress; Reactive Oxygen Species; Sirtuin 3; Zebrafish | 2020 |
The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis.
Topics: Amylases; Animals; Anthraquinones; Biphenyl Compounds; Disease Models, Animal; Enzyme Inhibitors; Lignans; Male; Metabolome; Mice; Mice, Inbred C57BL; Pancreas; Pancreatitis | 2020 |
Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy.
Topics: Animals; Biphenyl Compounds; Cell Proliferation; Cicatrix; Connective Tissue Growth Factor; Epidural Space; Extracellular Matrix; Fibroblasts; Fibrosis; Laminectomy; Lignans; Male; MAP Kinase Signaling System; Neuroprotective Agents; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2020 |
Polyphenol Honokiol and Flavone 2',3',4'-Trihydroxyflavone Differentially Interact with α-Synuclein at Distinct Phases of Aggregation.
Topics: alpha-Synuclein; Amyloid; Biphenyl Compounds; Flavones; Lignans; Polyphenols | 2020 |
A Simple and Sensitive Dispersive Micro-Solid-Phase Extraction Coupled with High-Performance Liquid Chromatography for Quantification of Honokiol and Magnolol in Complex Matrices.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Lignans; Magnolia; Solid Phase Extraction | 2020 |
The Effect of Honokiol on Ergosterol Biosynthesis and Vacuole Function in
Topics: Antifungal Agents; Biphenyl Compounds; Calcineurin; Candida albicans; Drug Resistance, Fungal; Ergosterol; Lignans; Magnolia; Microbial Sensitivity Tests; Plant Extracts; Vacuoles | 2020 |
Synthesis, Characterization and Biological Evaluation of Magnolol and Honokiol Derivatives with 1,3,5-Triazine of Metformin Cyclization.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Cyclization; Cytokines; Gene Expression Regulation; Humans; Lignans; Macrophages; Metformin; Mice; Molecular Structure; RAW 264.7 Cells; Structure-Activity Relationship; Triazines | 2020 |
Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells.
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Liberation; Humans; Kidney Neoplasms; Lignans; Polylactic Acid-Polyglycolic Acid Copolymer; Tissue Scaffolds | 2020 |
Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway.
Topics: Animals; Biphenyl Compounds; CASP8 and FADD-Like Apoptosis Regulating Protein; Fatty Liver; Food, Formulated; Lignans; Liver; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Methionine; Mice; Oxidative Stress | 2020 |
Honokiol-camptothecin loaded graphene oxide nanoparticle towards combinatorial anti-cancer drug delivery.
Topics: Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Drug Carriers; Graphite; Humans; Lignans; Nanoparticles | 2020 |
Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Biosensing Techniques; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cyclosporine; Cyclosporins; Dogs; Drug Evaluation, Preclinical; HEK293 Cells; Humans; In Vitro Techniques; Kinetics; Lentivirus; Ligands; Lignans; Madin Darby Canine Kidney Cells; MCF-7 Cells; Membrane Proteins; Resveratrol; Surface Plasmon Resonance | 2021 |
Honokiol regulates mitochondrial substrate utilization and cellular fatty acid metabolism in diabetic mice heart.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Antioxidants; Biphenyl Compounds; CD36 Antigens; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Lignans; Male; Mice, Inbred C57BL; Mitochondria, Heart; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Streptozocin; Superoxide Dismutase | 2021 |
Honokiol antagonizes doxorubicin resistance in human breast cancer via miR-188-5p/FBXW7/c-Myc pathway.
Topics: Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; F-Box-WD Repeat-Containing Protein 7; Female; Gene Expression Regulation, Neoplastic; Humans; Lignans; MicroRNAs; Proto-Oncogene Proteins c-myc; Signal Transduction | 2021 |
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
Topics: Apoptosis; Biological Products; Biphenyl Compounds; Cell Death; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Humans; In Vitro Techniques; Leukemia, Promyelocytic, Acute; Lignans; MAP Kinase Signaling System; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Honokiol inhibits hepatoma carcinoma cell migration through downregulated Cyclophilin B expression.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Cyclophilins; Down-Regulation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; Signal Transduction | 2021 |
Application of hollow fiber centrifugal ultrafiltrate purification as the pretreatment technology for traditional Chinese medicine: its application for analysis of honokiol and magnolol in TCM preparations containing Cortex Magnoliae Officinalis.
Topics: Biphenyl Compounds; Humans; Lignans; Medicine, Chinese Traditional; Reproducibility of Results; Technology | 2021 |
Honokiol exerts protective effects on neural myelin sheaths after compressed spinal cord injury by inhibiting oligodendrocyte apoptosis through regulation of ER-mitochondrial interactions.
Topics: Animals; Apoptosis; Biphenyl Compounds; Caspase 12; Caspase 3; Cytochromes c; Demyelinating Diseases; Endoplasmic Reticulum; Humans; Lignans; Mitochondria; Myelin Sheath; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2022 |
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Biphenyl Compounds; Brain; Brain-Derived Neurotrophic Factor; GABA Modulators; Humans; Lignans; Magnolia; Male; Mice; Neuroprotective Agents; Phytotherapy; Plant Bark; Plant Extracts; Receptor, Cannabinoid, CB1 | 2021 |
Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells.
Topics: Apoptosis; Biphenyl Compounds; Cell Survival; Endoplasmic Reticulum Stress; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Malondialdehyde; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Superoxide Dismutase | 2021 |
Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-β/Smad2/3 signaling inhibition.
Topics: Areca; Arecoline; Biphenyl Compounds; Cell Transdifferentiation; Fibroblasts; Humans; Lignans; Mouth Mucosa; Oral Submucous Fibrosis; Smad2 Protein; Transforming Growth Factors | 2021 |
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Biphenyl Compounds; Cell Culture Techniques; Cell Survival; Humans; Lignans; Magnolia; Mice; Microglia; Phagocytosis; Reactive Oxygen Species | 2021 |
A novel anticaries agent, honokiol-loaded poly(amido amine) dendrimer, for simultaneous long-term antibacterial treatment and remineralization of demineralized enamel.
Topics: Amines; Animals; Anti-Bacterial Agents; Biphenyl Compounds; Cariostatic Agents; Dendrimers; Dental Caries; Dental Enamel; Dentin; Lignans; Rats; Tooth Remineralization | 2021 |
Honokiol inhibits proliferation of colorectal cancer cells by targeting anoctamin 1/TMEM16A Ca
Topics: Anoctamin-1; Biphenyl Compounds; Calcium; Cell Proliferation; Chloride Channels; Colorectal Neoplasms; HEK293 Cells; Humans; Lignans | 2021 |
Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Biphenyl Compounds; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colitis; Colonic Neoplasms; Doublecortin-Like Kinases; Down-Regulation; Hippo Signaling Pathway; Humans; Intracellular Signaling Peptides and Proteins; Lignans; Male; Mice, Inbred ICR; Models, Biological; Neoplastic Stem Cells; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; Transcription Factors; Tumor Stem Cell Assay; YAP-Signaling Proteins | 2021 |
Honokiol: A naturally occurring lignan with pleiotropic bioactivities.
Topics: Apoptosis; Biphenyl Compounds; Drugs, Chinese Herbal; Humans; Lignans; Magnolia | 2021 |
Augment the efficacy of eradicating metastatic lesions and tumor proliferation in breast cancer by honokiol-loaded pH-sensitive targeted lipid nanoparticles.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hydrogen-Ion Concentration; Lignans; Lipids; Lung Neoplasms; Mice; Mice, Inbred BALB C; Nanoparticles | 2021 |
Mechanism of apoptotic induction on T24 cells by honokiol and its synergistic anticancer effect in combination with hydroxycamptothecin.
Topics: Apoptosis; Biphenyl Compounds; Camptothecin; Cell Line, Tumor; Lignans | 2021 |
Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy.
Topics: Antineoplastic Agents; Autophagy; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lignans; Molecular Structure; Oxadiazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship; Thiadiazoles; TOR Serine-Threonine Kinases | 2021 |
Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma.
Topics: Antineoplastic Agents; Biphenyl Compounds; Humans; Lignans; Melanoma; Tumor Microenvironment | 2021 |
Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis.
Topics: Acetylation; Animals; Biphenyl Compounds; Down-Regulation; Epithelial Cells; Fibrosis; Gene Ontology; Humans; Kidney Tubules; Lignans; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Peptide Fragments; Pyruvate Dehydrogenase Complex; Renal Insufficiency, Chronic; RNA, Messenger; Sirtuin 3; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2021 |
Honokiol-Based Nanomedicine Decorated with Ethylene Glycols Derivatives Promotes Antitumor Efficacy.
Topics: Biphenyl Compounds; Cell Line, Tumor; Drug Carriers; Ethylene Glycols; Lignans; Nanomedicine; Nanoparticles; Particle Size; Polyesters; Polyethylene Glycols | 2021 |
Engineered s-Triazine-Based Dendrimer-Honokiol Conjugates as Targeted MMP-2/9 Inhibitors for Halting Hepatocellular Carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dendrimers; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lignans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Molecular Structure; Structure-Activity Relationship; Triazines | 2021 |
Genetic Interpretation of the Impacts of Honokiol and EGCG on Apoptotic and Self-Renewal Pathways in HEp-2 Human Laryngeal CD44
Topics: Apoptosis; Biphenyl Compounds; Catechin; Cell Line, Tumor; Hedgehog Proteins; Humans; Hyaluronan Receptors; Laryngeal Neoplasms; Lignans; Neoplastic Stem Cells; Tumor Suppressor Protein p53 | 2022 |
A multidimensional biosensor system to guide LUAD individualized treatment.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biosensing Techniques; Biphenyl Compounds; Cell Culture Techniques; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lignans; Lung Neoplasms; Male; Mice; Mice, Nude; Piperidines; Precision Medicine; Quinazolines; Tumor Cells, Cultured | 2021 |
The Preventive Effect of Systemic Honokiol and Systemic Pentoxifylline on Epidural Fibrosis.
Topics: Animals; Biphenyl Compounds; Epidural Space; Fibrosis; Laminectomy; Lignans; Pentoxifylline; Rats | 2021 |
Improving the antioxidant activity of natural antioxidant honokiol by introducing the amino group.
Topics: Amines; Antioxidants; Biphenyl Compounds; Electrons; Hydrogen; Lignans; Molecular Conformation; Protons; Structure-Activity Relationship | 2021 |
Preliminary Assessment of the Anti-inflammatory Activity of New Structural Honokiol Analogs with a 4'-
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Fluorine Radioisotopes; Hydrocarbons, Fluorinated; Inflammation; Lignans; Male; Mice; Mice, Inbred C57BL; Radiopharmaceuticals | 2021 |
A honokiol-mediated robust coating for blood-contacting devices with anti-inflammatory, antibacterial and antithrombotic properties.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line; Coated Materials, Biocompatible; Escherichia coli; Fibrinolytic Agents; Lignans; Male; Mice; Microbial Sensitivity Tests; Rabbits; Rats, Sprague-Dawley; Staphylococcus aureus; Thrombosis | 2021 |
Construction, characterization, and bioavailability evaluation of honokiol-loaded porous starch by melting method without any solvent.
Topics: Animals; Area Under Curve; Biphenyl Compounds; Drug Carriers; Drug Liberation; Half-Life; Hep G2 Cells; Humans; Lignans; Porosity; Random Allocation; Rats; Rats, Sprague-Dawley; Solubility; Starch; Surface Properties; Technology, Pharmaceutical; Tumor Microenvironment | 2021 |
Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biphenyl Compounds; Cell Survival; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Lignans; Madin Darby Canine Kidney Cells; Magnolia; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Polyphenols; Signal Transduction | 2021 |
A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Kidney Neoplasms; Lignans; Mice; Organ Transplantation; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer's disease via inhibiting neuropathology and modulating gut microbiota.
Topics: Alzheimer Disease; Animals; Biphenyl Compounds; Cognition; Cognitive Dysfunction; Gastrointestinal Microbiome; Glycogen Synthase Kinase 3 beta; Lignans; Male; Mice; Neuroinflammatory Diseases | 2022 |
Natural Small Molecules Enabled Efficient Immunotherapy through Supramolecular Self-Assembly in P53-Mutated Colorectal Cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Biphenyl Compounds; Colorectal Neoplasms; Female; Humans; Immunotherapy; Lignans; Macromolecular Substances; Materials Testing; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Small Molecule Libraries; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2022 |
Honokiol suppresses 2,6-dinitrochlorobenzene-induced atopic dermatitis in mice.
Topics: Animals; Biphenyl Compounds; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Immunoglobulin E; Inflammation; Lignans; Magnolia; Male; Mast Cells; Mice; Mice, Inbred BALB C | 2022 |
Tumor-targeted delivery of honokiol via polysialic acid modified zein nanoparticles prevents breast cancer progression and metastasis.
Topics: Animals; Biphenyl Compounds; Breast Neoplasms; Drug Carriers; Female; Humans; Lignans; Mice; Nanoparticles; Particle Size; Sialic Acids; Tissue Distribution; Zein | 2022 |
Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle.
Topics: Animals; Biphenyl Compounds; Calcium Signaling; HEK293 Cells; Humans; Intestines; Lignans; Male; Medicine, Chinese Traditional; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; TRPV Cation Channels | 2022 |
Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis.
Topics: Animals; Apoptosis; Arsenic Trioxide; Biphenyl Compounds; Cardiotoxicity; Lignans; Magnolia; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Reactive Oxygen Species | 2022 |
Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance.
Topics: Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Insulin Resistance; Lignans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Vascular Diseases; Vasodilation | 2022 |
Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Apoptosis; Biphenyl Compounds; Cisplatin; Humans; Lignans; Mitochondrial Dynamics; Sirtuin 3 | 2022 |
Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway.
Topics: Animals; Apoptosis; Biphenyl Compounds; Humans; Leukemia; Lignans; Lymphoma, B-Cell; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2022 |
Honokiol nanosuspensions loaded thermosensitive hydrogels as the local delivery system in combination with systemic paclitaxel for synergistic therapy of breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydrogels; Lignans; Mice; Nanoparticles; Paclitaxel | 2022 |
PCAT19 Regulates the Proliferation and Apoptosis of Lung Cancer Cells by Inhibiting miR-25-3p via Targeting the MAP2K4 Signal Axis.
Topics: Animals; Anisomycin; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lignans; Lung Neoplasms; MAP Kinase Kinase 4; Mice; Mice, Nude; MicroRNAs; RNA, Long Noncoding | 2022 |
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.
Topics: alpha-Glucosidases; Angiotensin-Converting Enzyme 2; Biphenyl Compounds; COVID-19 Drug Treatment; HEK293 Cells; Humans; Lignans; Molecular Docking Simulation; Oxadiazoles; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Sulfides | 2022 |
The Modulation of Arachidonic Acid Metabolism and Blood Pressure-Lowering Effect of Honokiol in Spontaneously Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Biphenyl Compounds; Blood Pressure; Cytochrome P-450 CYP4A; Hypertension; Kidney; Lignans; Rats; Rats, Inbred SHR | 2022 |
Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38α in Alcoholic Liver Disease.
Topics: Animals; Cytokines; Interleukin-1beta; Interleukin-6; Lignans; Lipid Metabolism; Lipid Metabolism Disorders; Liver; Liver Diseases, Alcoholic; Mice; NF-kappa B; PPAR alpha; Sterols; Tumor Necrosis Factor-alpha | 2023 |
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cognition; Cognitive Dysfunction; DNA, Mitochondrial; Fluorides; Humans; Lignans; Mice; Mitochondria; Neuroblastoma; Oxidative Stress; RNA, Small Interfering; Sirtuin 3 | 2022 |
Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents.
Topics: Allyl Compounds; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Biphenyl Compounds; Lignans; Mice; Microbial Sensitivity Tests; Phenols | 2022 |
Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of Magnolia officinalis in functional dyspepsia and normal rats using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dyspepsia; Glycosides; Lignans; Magnolia; Plant Bark; Rats; Tandem Mass Spectrometry | 2022 |
Discovery of novel compounds as potent activators of Sirt3.
Topics: Acetylation; Allyl Compounds; Biphenyl Compounds; Humans; Lignans; Phenols; Sirtuin 3; Sirtuins | 2022 |
Transcriptomic analysis shows the antifungal mechanism of honokiol against Aspergillus flavus.
Topics: Antifungal Agents; Aspergillus flavus; Lignans; Transcriptome | 2023 |
A Chinese herb preparation, honokiol, inhibits Streptococcus mutans biofilm formation.
Topics: Biofilms; Dental Caries; Humans; Lactic Acid; Lignans; Streptococcus mutans | 2023 |
Reaction with ROO• and HOO• Radicals of Honokiol-Related Neolignan Antioxidants.
Topics: Antioxidants; Biphenyl Compounds; Free Radical Scavengers; Free Radicals; Lignans; Phenols | 2023 |
Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target.
Topics: Biphenyl Compounds; Humans; Lignans; Magnolia; Medicine, Chinese Traditional; Plant Bark; Plant Extracts; Respiratory Tract Diseases | 2023 |
Evaluation of honokiol, magnolol and of a library of new nitrogenated neolignans as pancreatic lipase inhibitors.
Topics: Biphenyl Compounds; Lignans | 2023 |
Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis.
Topics: Animals; Astrocytes; Brain Ischemia; Dementia; Lignans; Rats; Sirtuin 3 | 2023 |
Management of adenocarcinoma with honokiol: progress so far and the way forward.
Topics: Adenocarcinoma; Biphenyl Compounds; Humans; Lignans | 2023 |
Functional in situ formed deep eutectic solvents improving mechanical properties of powders by enhancing interfacial interactions.
Topics: Choline; Deep Eutectic Solvents; Humans; Lignans; Male; Powders; Solvents | 2023 |
[Processing Magnoliae Officinalis Cortex with ginger juice: process optimization based on AHP-CRITIC weighting method and composition changes after processing].
Topics: Biphenyl Compounds; Drugs, Chinese Herbal; Lignans; Magnolia; Zingiber officinale | 2023 |
Affinity character analysis of magnolol and honokiol based on stepwise frontal analysis coupled with cell membrane chromatography.
Topics: Biphenyl Compounds; Cell Membrane; Chromatography; Lignans; Vascular Endothelial Growth Factor A | 2023 |