Page last updated: 2024-08-16

fr 74366 and quinazolines

fr 74366 has been researched along with quinazolines in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (64.52)	18.2507
2000's	10 (32.26)	29.6817
2010's	1 (3.23)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Esumi, Y; Fujiwara, T; Tanaka, Y	1
Akagi, Y; Ibaraki, N; Ikebe, H; Matsumoto, Y; Okamoto, S; Terubayashi, H; Tsutsumi, M	1
Ishikawa, H; Kadoh, Y; Tanaka, Y	1
Esumi, Y; Katami, Y; Noda, K; Sawamoto, T; Sekiguchi, M; Tanaka, Y; Ueda, T	1
Holleschau, AM; Rathbun, WB; Tao, RV	1
Deguchi, Y; Ishii, I; Tanaka, Y; Terai, T	1
Ishikawa, H; Kadoh, Y; Mukumoto, S; Tanaka, Y	1
Ao, S; Kikuchi, C; Notsu, Y; Ono, T	1
Ao, S; Fujiwara, T; Kikuchi, C; Nomura, K; Notsu, Y; Ohkubo, Y; Shingu, Y; Takano, Y; Yamaguchi, I	1
Akagi, Y; Ikebe, H; Mori, K; Nishikawa, H; Okamoto, S; Terubayashi, H; Tsutsumi, M; Yoshizaki, K	1
Balaban, RS; Berkowitz, B; Kador, PF; Karino, K	1
Akagi, Y; Ikebe, H; Matsumoto, Y; Mori, K; Tanimoto, T; Terubayashi, H; Tsuji, T	1
Suzuki, A; Tanaka, Y	1
Hashimoto, M; Hata, T; Noguchi, H; Shimojyo, H; Tanaka, Y	1
Kanamaru, M; Mizuno, A; Nagashima, S; Nakashima, M; Sugiyama, A; Terakawa, M; Uematsu, T	1
Akagi, Y; Ikebe, H; Okamoto, S; Tanimoto, T; Terubayashi, H; Tsuji, T	1
Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y	1
Chen, Z; Kador, PF; Lee, YS	1
Arezzo, JC; Brown, MB; Greene, DA	1
Feldman, EL; Greene, DA; Stevens, MJ	1
Goto, T; Ikuma, K; Kawamura, I; Mutoh, S; Seki, J; Shimoshige, Y; Takakura, S; Yamamoto, T	1
Goto, T; Kawamura, I; Seki, J; Takakura, S; Yamamoto, T	1
Hasegawa, T; Kawamura, I; Kihara, M; Minoura, K; Mitsui, Y; Shioyama, M; Takahashi, M; Takakura, S	1
Fujii, T; Goto, T; Kinoshita, T; Miyake, H; Takakura, S	1
Kato, Y; Kuge, K; Kusuhara, H; Meier, PJ; Sugiyama, Y	1
Kato, N; Oka, M	1
Bird, SJ; Brown, MJ; Foyt, HL; Spino, C; Watling, S	1
de la Fuente, JA; Manzanaro, S; Salva, J	1
Kamijo, M; Matsuoka, N; Minoura, K; Mutoh, S; Shimoshige, Y; Takakura, S	1
Aoki, T; Enomoto, R; Kaneko, S; Matsuoka, N; Shimoshige, Y	1

Reviews

3 review(s) available for fr 74366 and quinazolines

Article	Year
Diabetic neuropathy: scope of the syndrome. The American journal of medicine, 1999, Aug-30, Volume: 107, Issue:2B Topics: Aldehyde Reductase; Animals; Chronic Disease; Controlled Clinical Trials as Topic; Diabetic Foot; Diabetic Neuropathies; Disease Progression; Enzyme Inhibitors; Humans; Neural Conduction; Prevalence; Quinazolines; Syndrome	1999
Aldose reductase inhibitors. Journal of enzyme inhibition, 2001, Volume: 16, Issue:6 Topics: Aldehyde Reductase; Binding Sites; Clinical Trials as Topic; Crystallography, X-Ray; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Naphthalenes; Quinazolines	2001
Zenarestat. FK 366, FR 74366, FR 901366. Drugs in R&D, 2002, Volume: 3, Issue:4 Topics: Animals; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Quinazolines	2002

Trials

2 trial(s) available for fr 74366 and quinazolines

Article	Year
Aldose reductase inhibitory and uricosuric activities of FK366 in healthy volunteers. Journal of clinical pharmacology, 1993, Volume: 33, Issue:11 Topics: Adult; Aldehyde Reductase; Drug Administration Schedule; Humans; Male; Quinazolines; Uric Acid; Uricosuric Agents	1993
Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group. Neurology, 1999, Aug-11, Volume: 53, Issue:3 Topics: Action Potentials; Aldehyde Reductase; Biopsy; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Neural Conduction; Quinazolines	1999

Other Studies

26 other study(ies) available for fr 74366 and quinazolines

Article	Year
Sex difference in the excretion of zenarestat in mice, rats, dogs and humans. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:8 Topics: Adult; Aged; Aldehyde Reductase; Animals; Blood Proteins; Dogs; Female; Humans; Male; Mice; Mice, Inbred ICR; Middle Aged; Probenecid; Protein Binding; Quinazolines; Rats; Rats, Sprague-Dawley; Sex Factors	1992
[Ciliary body changes associate with aldose reductase in galactosemic rats (2)]. Nippon Ganka Gakkai zasshi, 1992, Volume: 96, Issue:7 Topics: Aldehyde Reductase; Animals; Ciliary Body; Epithelium; Galactosemias; Hypertrophy; Quinazolines; Rats	1992
Effects of hypophysectomy and testosterone treatment on the urinary excretion of zenarestat in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:1 Topics: Animals; Blood Proteins; Feces; Female; Hypophysectomy; Male; Quinazolines; Rats; Rats, Inbred Strains; Testosterone	1992
Absorption, distribution and excretion of zenarestat, a new aldose reductase inhibitor, in rats and dogs. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:1 Topics: Absorption; Aldehyde Reductase; Animals; Bile; Biological Availability; Blood Proteins; Dogs; Feces; Half-Life; Male; Quinazolines; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution	1992
Naphthalene-induced cataract in the rat. II. Contrasting effects of two aldose reductase inhibitors on glutathione and glutathione redox enzymes. Ophthalmic research, 1991, Volume: 23, Issue:5 Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Disease Models, Animal; Female; Fluorenes; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hydantoins; Lens, Crystalline; Naphthalenes; Organ Size; Quinazolines; Random Allocation; Rats; Rats, Inbred BN	1991
Sex differences in excretion of zenarestat in rat. Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:9 Topics: Aldehyde Reductase; Animals; Bile; Biotransformation; Blood Proteins; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Feces; Female; Glucuronates; Male; Probenecid; Protein Binding; Quinazolines; Rats; Rats, Inbred Strains; Sex Characteristics	1991
The role of age and sex hormones on the urinary excretion of zenarestat in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:10 Topics: Age Factors; Aldehyde Reductase; Animals; Female; Gonadal Steroid Hormones; Male; Orchiectomy; Ovariectomy; Probenecid; Quinazolines; Rats; Rats, Inbred Strains; Sex Factors; Testosterone	1991
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract. Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:12 Topics: Administration, Topical; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Male; Quinazolines; Rats; Rats, Inbred Strains; Retina; Sorbitol; Streptozocin	1991
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. Metabolism: clinical and experimental, 1991, Volume: 40, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Neuropathies; Diabetic Retinopathy; Female; Kinetics; Lens, Crystalline; Male; Motor Neurons; Neural Conduction; Quinazolines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1991
[Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance]. Nippon Ganka Gakkai zasshi, 1991, Volume: 95, Issue:4 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Magnetic Resonance Spectroscopy; Male; Quinazolines; Rats; Time Factors	1991
19F NMR quantitation of lens aldose reductase activity using 3-deoxy-3-fluoro-D-glucose. The Journal of biological chemistry, 1991, Nov-05, Volume: 266, Issue:31 Topics: Aldehyde Reductase; Animals; Deoxyglucose; Dogs; In Vitro Techniques; Kinetics; Lens, Crystalline; Magnetic Resonance Spectroscopy; Quinazolines; Sorbitol	1991
[Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract]. Nippon Ganka Gakkai zasshi, 1990, Volume: 94, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Galactose; Quinazolines; Rats; Sugar Alcohol Dehydrogenases	1990
Enzymatic hydrolysis of zenarestat 1-O-acylglucuronide. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:3 Topics: Aldehyde Reductase; Animals; Buffers; Chromatography, High Pressure Liquid; Female; Glucuronates; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isomerism; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Protein Denaturation; Quinazolines; Rats; Rats, Sprague-Dawley; Species Specificity	1994
Toxicokinetics of zenarestat, an aldose reductase inhibitor in animals and man. Xenobiotica; the fate of foreign compounds in biological systems, 1994, Volume: 24, Issue:5 Topics: Administration, Oral; Adult; Aldehyde Reductase; Animals; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Quinazolines; Rats; Rats, Sprague-Dawley	1994
[Prefeeding of aldose reductase inhibitor inhibits galactose cataract]. Nippon Ganka Gakkai zasshi, 1993, Volume: 97, Issue:4 Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Galactitol; Galactose; Premedication; Quinazolines; Rats; Rats, Sprague-Dawley	1993
Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. Toxicology, 1997, Dec-05, Volume: 123, Issue:3 Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose Tolerance Test; Glutathione; Immunosuppressive Agents; Insulin; Lens, Crystalline; Male; Quinazolines; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol; Tacrolimus	1997
Molecular modeling studies of the binding modes of aldose reductase inhibitors at the active site of human aldose reductase. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:10 Topics: Acetates; Aldehyde Reductase; Binding Sites; Enzyme Inhibitors; Fluorenes; Glyceraldehyde; Humans; Imidazoles; Imidazolidines; Models, Molecular; Quinazolines; Rhodanine; Spiro Compounds; Structure-Activity Relationship; Thiazolidines	1998
The effects of zenarestat, an aldose reductase inhibitor, on peripheral neuropathy in Zucker diabetic fatty rats. Metabolism: clinical and experimental, 2000, Volume: 49, Issue:11 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhibitors; Male; Quinazolines; Rats; Rats, Zucker	2000
The effects of zenarestat, an aldose reductase inhibitor, on minimal F-wave latency and nerve blood flow in streptozotocin-induced diabetic rats. Life sciences, 2001, Feb-09, Volume: 68, Issue:12 Topics: Aldehyde Reductase; Animals; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neural Conduction; Quinazolines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Streptozocin	2001
Effect of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow in experimental diabetic neuropathy of rat. Neuroscience letters, 2001, Sep-14, Volume: 310, Issue:2-3 Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Enzyme Inhibitors; Hydrogen; Male; Microelectrodes; Nitric Oxide; Nitroarginine; Peripheral Nerves; Quinazolines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve	2001
The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat. Acta crystallographica. Section D, Biological crystallography, 2002, Volume: 58, Issue:Pt 4 Topics: Aldehyde Reductase; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Quinazolines; Recombinant Proteins	2002
Gender difference in the urinary excretion of organic anions in rats. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Female; Kidney; Kinetics; Liver; Male; Organic Anion Transporters, Sodium-Independent; Quinazolines; Rats; Sex Characteristics; Sulfobromophthalein; Taurocholic Acid; Transfection; Urinary Bladder	2002
Value of repeated measures of nerve conduction and quantitative sensory testing in a diabetic neuropathy trial. Muscle & nerve, 2006, Volume: 34, Issue:2 Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Algorithms; Cold Temperature; Data Interpretation, Statistical; Diabetic Neuropathies; Electrophysiology; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Neural Conduction; Neurons, Afferent; Quinazolines; Reproducibility of Results; Sample Size; Thermosensing; Vibration	2006
Phenolic marine natural products as aldose reductase inhibitors. Journal of natural products, 2006, Volume: 69, Issue:10 Topics: Aldehyde Reductase; Animals; Biological Products; Humans; Imidazolidines; Marine Biology; Naphthalenes; Quinazolines; Rhodanine; Thiazolidines; Urochordata	2006
Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats. Brain research, 2009, Jan-09, Volume: 1247 Topics: Aldehyde Reductase; Animals; Axons; Cell Death; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Male; Nerve Degeneration; Polymers; Quinazolines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sural Nerve; Treatment Outcome; Wallerian Degeneration	2009
The involvement of aldose reductase in alterations to neurotrophin receptors and neuronal cytoskeletal protein mRNA levels in the dorsal root ganglion of streptozotocin-induced diabetic rats. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:1 Topics: Aldehyde Reductase; Animals; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Ganglia, Spinal; Male; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; Polymers; Quinazolines; Rats; Receptors, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tubulin	2010