folic acid and nadp
folic acid has been researched along with nadp in 191 studies
Research
Studies (191)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 101 (52.88) | 18.7374 |
| 1990's | 31 (16.23) | 18.2507 |
| 2000's | 34 (17.80) | 29.6817 |
| 2010's | 19 (9.95) | 24.3611 |
| 2020's | 6 (3.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Harrap, KR; Hart, LI; Jackson, RC | 1 |
| Rao, NA; Reddy, VA | 1 |
| Cohen, L; Mackenzie, RE | 1 |
| Kaufman, BT; Subramanian, S | 1 |
| Bayley, PM; Hood, K; Roberts, GC | 1 |
| Smith, RN | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Roberts, GC; Way, JL | 1 |
| Greenfield, NJ | 1 |
| Eguchi, T; Inoue, K; Kuge, Y; Mochida, K; Uwajima, T; Yoshikawa, N | 1 |
| Birdsall, B; Cheung, HT; Feeney, J | 1 |
| Denny, BJ; Griffin, RJ; Lambert, PA; Meek, MA; Ringan, NS; Schwalbe, CH; Stevens, MF | 1 |
| Bajorath, J; Hagler, AT; Kitson, DH; Kraut, J; Li, ZQ | 1 |
| Roberts, GC | 2 |
| Morrison, JF; Williams, EA | 1 |
| Rancourt, SL; Walker, VK | 1 |
| Bystroff, C; Kraut, J; Oatley, SJ | 1 |
| Freisheim, JH; Huang, SM; Ratnam, M; Tan, XH; Thompson, PD | 1 |
| Ashford, VA; Davies, JF; Delcamp, TJ; Freisheim, JH; Kraut, J; Prendergast, NJ | 1 |
| Carpano, P; Cercignani, G; Degan, P; Montagnoli, G | 1 |
| Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ | 1 |
| Morrison, JF; Stone, SR | 3 |
| Birdsall, B; Colwell, WT; Crase, J; De Graw, J; Feeney, J; Hammond, S; Roberts, GC; Searle, MS | 1 |
| Benkovic, SJ; Fierke, CA; Johnson, KA | 1 |
| Benkovic, SJ; Chen, JT; Taira, K; Tu, CP | 1 |
| MacKenzie, RE; Smith, DD | 1 |
| Henkin, J; Johanson, RA | 1 |
| Frieden, C; Penner, MH | 1 |
| Kikuchi, G; Yoshida, T | 2 |
| Onicescu, D; Taşcă, L; Trutza, E | 1 |
| Greenfield, NJ; Hoogsteen, K; Poe, M; Williams, MN | 1 |
| Sirotnak, FM | 1 |
| Frisell, WR; Randolph, VM | 1 |
| Bhat, JV; Nambudiri, AM | 1 |
| Greenfield, NJ; Hirshfield, JM; Hoogsteen, K; Poe, M; Williams, MN | 2 |
| Jones, EW; Lam, KB | 2 |
| Dawes, J; Goldberg, EB | 1 |
| Kaplan, NO; Kisliuk, RL; Pastore, EJ; Plante, LT; Wright, JM | 1 |
| Gawthorne, JM; Osborne-White, WS; Smith, RM | 1 |
| Gawthorne, JM; Smith, RM | 1 |
| DiGirolamo, PM; Fujii, K; Henderson, GB; Huennekens, FM; Jacobsen, DW; Neef, VG; Rader, JI | 1 |
| Donaldson, KO; Scott, VF | 1 |
| Greenberg, DM; Yeh, YC | 1 |
| Grossowicz, N; Hla-Pe, U; Shavit, F | 1 |
| Bush, ME; Donaldson, KO | 1 |
| Rothenberg, SP | 1 |
| Bertino, JR; Perkins, JP | 1 |
| Zakrzewski, S | 1 |
| Hecker, E; Marks, F | 2 |
| Ferone, R; Hitchings, GH | 1 |
| Jaffe, JJ; McCormack, JJ | 1 |
| Dalal, FR; Gots, JS | 1 |
| Bertino, JR; Hillcoat, BL; Perkins, JP | 1 |
| Gräser, H | 1 |
| Blakley, RL; Hillcoat, BL; Nixon, PF | 1 |
| Kutzbach, C; Stokstad, EL | 2 |
| Hakala, MT | 1 |
| Andreeva, NA; Efimova, RI | 1 |
| Burchall, J | 1 |
| Homi, ML; Magar, ME | 1 |
| Kaufman, BT | 1 |
| Burchall, JJ; Hitchings, GH | 1 |
| Gutteridge, WE; Jaffe, JJ; McCormack, JJ | 1 |
| Kikuchi, G; Kochi, H | 1 |
| Butt, VS; Vaughan, PF | 1 |
| Heinemann, M; Sloane, NH | 1 |
| Leclerc, M | 1 |
| Bertino, JR; Cashmore, AR; Hillcoat, BL | 1 |
| Dunlap, RB; Gundersen, LE; Huennekens, FM | 1 |
| Holland, P; Little, C | 1 |
| Russell, DW | 1 |
| Harding, NG; Newbold, PC | 1 |
| Pastore, EJ | 1 |
| Turner, JM; Willetts, AJ | 1 |
| Dunlap, RB; Freisheim, JH; Gundersen, LE; Harding, NG; Huennekens, FM; Otting, F | 1 |
| Gauldie, J; Hillcoat, BL | 1 |
| Bertino, JR; McCullough, JL | 1 |
| Jaenicke, L; Nagelschmidt, M | 1 |
| D'Souza, L; Freisheim, JH | 1 |
| Schalhorn, A; Wilmanns, W | 1 |
| Dann, JG; Harding, NG; Newbold, PC; Whiteley, JM | 1 |
| Erickson, JS; Mathews, CK | 1 |
| Bolard, J; Seng, G | 1 |
| Ahmed, F; Dunlap, RB | 1 |
| Drummond, D; MacKenzie, RE; Smith, S | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Gronenborn, A; Kaptein, R; Roberts, GC | 1 |
| Birdsall, B; Burgen, AS; Clore, GM; Feeney, J; Gronenborn, A; Roberts, GC | 1 |
| Dunlap, RB; Rosson, D | 1 |
| Aull, JL; Daron, HH | 1 |
| Birdsall, B; Burgen, AS; Clore, GM; Feeney, J; Gronenborn, A; Hyde, EI; Roberts, GC | 1 |
| Cayley, PJ; Dunn, SM; King, RW | 1 |
| Blakley, RL; Cocco, L; Groff, JP; London, RE | 1 |
| Da Costa, M; Iqbal, MP; Rothenberg, SP | 1 |
| Benkovic, SJ; Huang, Z; Wagner, CR | 1 |
| Appleman, JR; Blakley, RL; Nakano, T; Spencer, HT | 1 |
| Benkovic, SJ; Falzone, CJ; Wright, PE | 1 |
| Appling, DR; García-Martínez, LF | 1 |
| Allegra, CJ; Chu, E; Grem, JL; Takimoto, CH; Voeller, D | 1 |
| Benkovic, SJ; Bethell, R; Li, L; Posner, BA; Tsuji, T | 1 |
| Huennekens, FM | 1 |
| Beechem, JM; Bradrick, TD; Howell, EE | 1 |
| Huang, T; Kim, DW; Schirch, D; Schirch, V | 1 |
| Basran, J; Birdsall, B; Casarotto, MG; Cheung, HT; Feeney, J; Roberts, GC | 1 |
| Beverley, SM; Hardy, LW; Nare, B | 1 |
| Wang, ZX; Wu, JW; Zhou, JM | 1 |
| Schuman Jorns, M; Wagner, MA | 1 |
| Bray, T; Chang, CF; Leblanc, E; Lin, SX; Ouellette, M; Papadopoulou, B; Wang, J; Whiteley, JM | 1 |
| Duncan, R; Santi, DV; Trujillo, M | 1 |
| Cook, RJ | 1 |
| Frieden, C; Hoeltzli, SD | 1 |
| Bradrick, TD; Howell, EE; Park, H | 1 |
| Blakley, RL; Cody, V; Galitsky, N; Gangjee, A; Luft, JR; Pangborn, W | 1 |
| Cody, V; Galitsky, N; Luft, JR; Pangborn, W; Queener, SF; Rak, D | 1 |
| Friedman, M; McDonald, GM | 1 |
| Birdsall, B; Feeney, J; Polshakov, VI | 2 |
| Akasaka, K; Gekko, K; Kitahara, R; Ohmae, E; Sareth, S; Yamada, H | 1 |
| Callender, R; Deng, H; Howell, E | 1 |
| Appling, DR; Chan, SY; Hanson, AD; Horne, DW; Kaplan, F; Raymond, RK; Roje, S | 1 |
| Hicks, SN; Howell, EE; Saxton, AM; Smiley, RD; Stinnett, LG | 1 |
| Hicks, SN; Howell, EE; Kuhn, LA; Shukla, U; Smiley, RD; Zavodszky, MI | 1 |
| Anderson, KS; Atreya, CE; Chang, SY; Johnson, EF; Liang, PH; Williamson, J | 1 |
| Allemann, RK; Javed, MH; Maglia, G | 1 |
| Baell, J; Coloe, P; Fernley, R; Macreadie, I; Patel, O; Satchell, J | 1 |
| Brown, ED; Cechetto, JD; Daigle, DM; Hartlen, R; Zolli-Juran, M | 1 |
| Hamilton, JB; Hicks, SN; Howell, EE; Smiley, RD | 1 |
| AKINO, M; MATSUBARA, M; TSUSUE, M | 1 |
| BLAKLEY, RL; RAMASASTRI, BV | 1 |
| MISRA, DK | 1 |
| BERTINO, JR; BIEBER, AL; BOOTH, BA; CASHMORE, A; SARTORELLI, AC | 1 |
| ELISON, C; ELLIOTT, HW | 1 |
| GREENBERG, DM; MORALES, DR | 1 |
| BUCHANAN, JM; ELFORD, HL; LOUGHLIN, RE | 1 |
| DONATI, GJ; HUTCHISON, DJ; SIROTNAK, FM | 1 |
| KENNEDY, EP; LINDBERG, M; TIETZ, A | 1 |
| CRAWFORD, EJ; FRIEDKIN, M; GOLDIN, A; HUMPHREYS, SR; KASHKET, ER | 1 |
| MAINWARING, WI; WILLIAMS, DC | 1 |
| Dyson, HJ; Osborne, MJ; Venkitakrishnan, RP; Wright, PE | 1 |
| Allemann, RK; Maglia, G | 1 |
| Gao, J; Garcia-Viloca, M; Truhlar, DG | 1 |
| Kohen, A; Markham, KA; Sikorski, RS | 1 |
| Dyson, HJ; Schnell, JR; Wright, PE | 1 |
| Benkovic, SJ; Hammes, GG; Rajagopalan, PT; Selzer, T; Zhang, Z | 1 |
| Griffin, J; Iliffe-Lee, E; McClarty, G; Roshick, C | 1 |
| Benkovic, SJ; Dyson, HJ; McElheny, D; Venkitakrishnan, RP; Wright, PE; Zaborowski, E | 1 |
| Dyson, HJ; Lansing, JC; McElheny, D; Schnell, JR; Wright, PE | 1 |
| Howell, EE | 1 |
| Ainavarapu, SR; Badilla, CL; Fernandez, JM; Li, L | 1 |
| Chopra, S; Howell, EE; Jackson, M; Kalman, TI; Levy, L; London, RE; Maynord, PO; Rosowsky, A; Smiley, RD | 1 |
| Carson, M; Chattopadhyay, D; Delucas, L; Howard, A; Pal, B; Schormann, N; Senkovich, O; Smith, C | 1 |
| Antikainen, NM; Benkovic, SJ; Hammes, GG; Smiley, RD | 1 |
| Ainavarapu, SR; Fernandez, JM; Li, L | 1 |
| Quaye, IK; Sandefur, CI; Sibley, CH; Sirawaraporn, W; Wooden, JM | 1 |
| Bozzo, GG; Gregory, JF; Hanson, AD; Naponelli, V; Noiriel, A | 1 |
| DeRose, EF; Howell, EE; Jackson, MR; Krahn, JM; London, RE | 1 |
| Chopra, S; Dooling, RM; Horner, CG; Howell, EE | 1 |
| O'Neill, HC; Rancourt, RC; White, CW | 1 |
| Cabezas-Herrera, J; Chazarra, S; Otón, F; Rodríguez-López, JN; Sánchez-del-Campo, L; Tárraga, A | 1 |
| Arora, K; Brooks Iii, CL | 1 |
| Benkovic, SJ; Bhabha, G; Dyson, HJ; Ekiert, DC; Gam, J; Lee, J; Wilson, IA; Wright, PE | 1 |
| Bhabha, G; Martinez-Yamout, MA; Tuttle, L; Wright, PE | 1 |
| Allemann, RK; Crump, MP; Dawson, WM; Evans, RM; Günther, UL; Loveridge, EJ; Matthews, SM; Whittaker, SB; Williams, C | 1 |
| Bertino, JR; Boros, LG; Chan, LL; DiPaola, RS; Dolfi, SC; Dvorzhinski, D; Gounder, M; Hirshfield, KM; Lin, H; Markert, EK; Oltvai, ZN; Qiu, J; Tedeschi, PM; Vazquez, A | 1 |
| Appling, DR; Bryant, JD; Momb, J; Shin, M | 1 |
| Fan, J; Kamphorst, JJ; Rabinowitz, JD; Shlomi, T; Thompson, CB; Ye, J | 1 |
| Bennett, BC; Dealwis, C; Kovalevsky, AY; Langan, P; Wan, Q; Wilson, MA | 1 |
| Allemann, RK; Behiry, EM; Evans, RM; Guo, J; Loveridge, EJ | 1 |
| Dyson, HJ; Fenwick, RB; Oyen, D; Stanfield, RL; Wright, PE | 1 |
| Agathocleous, M; DeBerardinis, RJ; Hu, Z; Huddlestun, SE; Johnson, TM; Leitch, AM; Morrison, SJ; Murphy, MM; Piskounova, E; Zhao, Z | 1 |
| Agarwal, PK; Chopra, S; Duff, MR; Howell, EE; Strader, MB | 1 |
| Fan, J; Liu, L; Park, JO; Rabinowitz, JD; Shah, S; Wellen, KE | 1 |
| Chen, L; Ducker, GS; Esposito, M; Ghergurovich, JM; Kang, Y; Morscher, RJ; Rabinowitz, JD; Teng, X | 1 |
| Allemann, RK; Angelastro, A; Davies, RL; Hroch, L; Hughes, RL; Loveridge, EJ; Luk, LY; Maglia, G; Williams, T | 1 |
| Kohen, A; Major, DT; Mhashal, AR; Vardi-Kilshtain, A | 1 |
| Blancquaert, D; Cuypers, A; De Lepeleire, J; Gorelova, V; Leroux, O; Meï, C; Pluim, D; Rébeillé, F; Schellens, JHM; Stove, CP; Van Daele, J; Van Der Straeten, D | 1 |
| Nagae, T; Watanabe, N; Yamada, H | 1 |
| Arany, Z; Chen, L; Hoshino, A; Morley, M; Rabinowitz, JD; Zhang, Z; Zheng, HD | 1 |
| Cahir-McFarland, E; Ersing, I; Gewurz, BE; Gygi, SP; Ma, Y; Mootha, VK; Nobre, L; Nomburg, J; Paulo, JA; Reinstadler, B; Shen, H; Smith, NA; Sommermann, T; Trudeau, S; Wang, LW; Wang, Z; Weekes, MP | 1 |
| Chen, H; Chen, W; Chen, YQ; Gu, Z; Lu, W; Wang, H; Wang, Q; Zhang, C; Zhang, H; Zhao, J | 1 |
| Berisa, M; Cross, JR; Jiang, X; Kyung, YJ; Ryu, KW; Schwörer, S; Thompson, CB; Yi, J; Zhu, J | 1 |
| Clasquin, MF; Rabinowitz, JD; TeSlaa, T; Tesz, GJ; Xing, G; Xu, X; Yang, L; Zeng, X; Zhang, Z | 1 |
| Dello Iacono, L; Di Pisa, F; Mangani, S | 1 |
| Eck, T; Frey, KM; Goodey, NM; Gubler, U; Janson, CA; Lange, K | 1 |
| Bruning, JB; Jayapalan, JJ; Jovcevski, B; Maenpuen, S; Pantong, W; Pederick, JL; Salaemae, W; Tinikul, R; Wegener, KL | 1 |
Reviews
5 review(s) available for folic acid and nadp
| Article | Year |
|---|---|
Conformational flexibility and protein specificity.
Topics: Binding Sites; Folic Acid; Folic Acid Antagonists; Mutagenesis, Site-Directed; NADP; Protein Conformation; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1991 |
Folic acid and vitamin B12: transport and conversion to coenzyme forms.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Membrane; Coenzymes; Folic Acid; Kinetics; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Models, Biological; Mutation; NADP; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Vitamin B 12 | 1974 |
Inhibition of folate biosynthesis and function as a basis for chemotherapy.
Topics: Aminobenzoates; Animals; Binding Sites; Biological Transport; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Folic Acid; Folic Acid Antagonists; Glutamates; Guinea Pigs; Humans; Lactobacillus; Leucovorin; Methotrexate; NAD; NADP; Pteridines; Pyrimidines; Rabbits; Rats; Sulfonamides | 1965 |
Postharvest changes in glycoalkaloid content of potatoes.
Topics: Folic Acid; Food Handling; Food Irradiation; Gene Expression Regulation; Glucose-6-Phosphate; Hot Temperature; Humans; Humidity; Light; NADP; Plant Structures; Solanaceous Alkaloids; Solanum tuberosum; Taste | 1999 |
Searching sequence space: two different approaches to dihydrofolate reductase catalysis.
Topics: Binding Sites; Catalysis; Catalytic Domain; Escherichia coli; Folic Acid; Ligands; Models, Molecular; Mutagenesis, Site-Directed; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2005 |
Other Studies
186 other study(ies) available for folic acid and nadp
| Article | Year |
|---|---|
Intrinsic resistance to methotrexate of cultured mammalian cells in relation to the inhibition kinetics of their dihydrololate reductases.
Topics: Biological Transport; Cell Membrane; Cells, Cultured; Drug Resistance; Folic Acid; Folic Acid Antagonists; Kinetics; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1976 |
Dihydrofolate reductase from soybean seedlings: a fluorescence and circular dichroism study.
Topics: Circular Dichroism; Folic Acid; Glycine max; Guanidines; Methotrexate; NADP; Plants; Protein Binding; Protein Conformation; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1977 |
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme.
Topics: Aminohydrolases; Animals; Folic Acid; Formate-Tetrahydrofolate Ligase; Kinetics; Ligases; Liver; Methylenetetrahydrofolate Dehydrogenase (NADP); Multienzyme Complexes; NADP; Oxidoreductases; Swine; Tetrahydrofolates | 1978 |
Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies.
Topics: Animals; Calorimetry; Chickens; Folic Acid; Liver; Methotrexate; NAD; NADP; Protein Binding; Protons; Spectrum Analysis; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1978 |
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R.
Topics: Circular Dichroism; Folic Acid; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1979 |
A simple assembly for anaerobic spectrophotometric reaction kinetics studies.
Topics: Anaerobiosis; Folic Acid; Kinetics; NADP; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1979 |
A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to Lactobacillus casei dihydrofolate reductase.
Topics: Amides; Aminopterin; Binding Sites; Carbon Isotopes; Carboxylic Acids; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Mathematics; Methotrexate; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1975 |
Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli B, MB 1428: ternary complexes.
Topics: Adenosine Diphosphate Sugars; Binding Sites; Circular Dichroism; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Methotrexate; NAD; NADP; Nicotinamide Mononucleotide; Protein Binding; Protein Conformation; Ribose; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1975 |
NADPH regeneration by glucose dehydrogenase from Gluconobacter scleroides for l-leucovorin synthesis.
Topics: Folic Acid; Glucose 1-Dehydrogenase; Glucose Dehydrogenases; Leucovorin; NADP; Pseudomonadaceae; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1992 |
13C NMR studies of complexes of Escherichia coli dihydrofolate reductase formed with methotrexate and with folic acid.
Topics: Escherichia coli; Folic Acid; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase | 1992 |
Structural studies on bio-active compounds. 20. Molecular modeling and crystallographic studies on methylbenzoprim, a potent inhibitor of dihydrofolate reductase.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; Crystallization; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Molecular Conformation; Molecular Structure; NADP; Pyrimidines; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1992 |
Theoretical studies on the dihydrofolate reductase mechanism: electronic polarization of bound substrates.
Topics: Binding Sites; Computer Simulation; Folic Acid; Models, Molecular; Models, Theoretical; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1991 |
Characterization of tightly bound substrates in pure preparations of dihydrofolate reductase: implications for studies on enzymes.
Topics: Chromatography; Folic Acid; Isoelectric Focusing; Kinetics; NADP; Protein Binding; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1991 |
Kinetic characterization of dihydrofolate reductase from Drosophila melanogaster.
Topics: Animals; Drosophila melanogaster; Folic Acid; Folic Acid Antagonists; Kinetics; NADP; Organomercury Compounds; Potassium Chloride; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Urea | 1990 |
Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Topics: Catalysis; Escherichia coli; Folic Acid; Kinetics; Models, Chemical; NADP; Protein Conformation; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1990 |
The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis.
Topics: Antibodies; Base Sequence; Binding, Competitive; Cloning, Molecular; Cyanogen Bromide; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Molecular Sequence Data; Mutation; NADP; Peptide Fragments; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Transformation, Bacterial | 1990 |
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.
Topics: Binding Sites; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Molecular; Molecular Structure; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1990 |
A fluorescence study of substrate and inhibitor binding to bovine liver dihydrofolate reductase.
Topics: Animals; Binding, Competitive; Cattle; Folic Acid; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; NADP; Protein Binding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1989 |
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 1989 |
Dihydrofolate reductase from Escherichia coli: the kinetic mechanism with NADPH and reduced acetylpyridine adenine dinucleotide phosphate as substrates.
Topics: Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NAD; NADP; Tetrahydrofolate Dehydrogenase; Viscosity | 1988 |
Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate.
Topics: Aspartic Acid; Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NADP; Solvents; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1988 |
15N and 1H NMR evidence for multiple conformations of the complex of dihydrofolate reductase with its substrate, folate.
Topics: Bacterial Proteins; Folic Acid; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1987 |
Dihydrofolate reductase: specificity and conformational change.
Topics: Binding Sites; Folic Acid; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Protein Conformation; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1987 |
Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.
Topics: Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Escherichia coli; Evaluation Studies as Topic; Folic Acid; Hydrogen-Ion Concentration; Mutation; NADP; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1987 |
Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Topics: Amino Acids; Binding Sites; Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Mutation; NADP; Phenylalanine; Plasmids; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tyrosine; Valine | 1987 |
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.
Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1986 |
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate-cyclohydrolase-formyltetrahy dro folate synthetase. Affinity labelling of the dehydrogenase-cyclohydrolase active site.
Topics: Affinity Labels; Aminohydrolases; Animals; Binding Sites; Folic Acid; Formate-Tetrahydrofolate Ligase; Ligases; Liver; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); NADP; Oxidoreductases; Pteroylpolyglutamic Acids; Swine | 1985 |
Affinity labeling of dihydrofolate reductase with an antifolate glyoxal.
Topics: Affinity Labels; Arginine; Binding, Competitive; Escherichia coli; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Lactobacillus; NADP; Peptide Fragments; Protein Denaturation; Pterins; Tetrahydrofolate Dehydrogenase | 1985 |
Substrate-induced hysteresis in the activity of Escherichia coli dihydrofolate reductase.
Topics: Binding Sites; Escherichia coli; Folic Acid; Kinetics; NADP; Tetrahydrofolate Dehydrogenase; Time Factors | 1985 |
Significance of the glycine cleavage system in glycine and serine catabolism in avian liver.
Topics: Ammonium Chloride; Animals; Arylformamidase; Bicarbonates; Carbon Dioxide; Carbon Isotopes; Chickens; Columbidae; Cycloserine; Cysteine; Enzyme Activation; Folic Acid; Glycine; Hydroxylamines; Hypoxanthines; L-Serine Dehydratase; Liver; Male; Mitochondria, Liver; NAD; NADP; Oxidoreductases; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Semicarbazides; Serine; Species Specificity; Subcellular Fractions; Transferases; Uric Acid | 1971 |
A histochemical method for dihydrofolate reductase.
Topics: Adrenal Glands; Animals; Brain; Cerebellum; Connective Tissue; Connective Tissue Cells; Epithelial Cells; Epithelium; Folic Acid; Histocytochemistry; Intestinal Mucosa; Kidney; Leukocytes; Liver; Muscles; Myocardium; NADP; Neurons; Rats; Spectrophotometry; Staining and Labeling; Tetrahydrofolate Dehydrogenase | 1970 |
Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.
Topics: Binding Sites; Chromatography, Ion Exchange; Circular Dichroism; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Mathematics; Methotrexate; NADP; Optical Rotatory Dispersion; Protein Binding; Protein Conformation; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1972 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
Effect of adenine nucleotides on the oxidation of methyl groups in liver mitochondria.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Animals; Carbon Dioxide; Dinitrophenols; Folic Acid; Formaldehyde; Formates; Glycine; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylation; Mitochondria, Liver; Mitochondrial Swelling; NAD; NADP; Oxygen Consumption; Rats; Rotenone; Sarcosine; Semicarbazides; Serine | 1973 |
Conversion of p-coumarate into caffeate by Streptomyces nigrifaciens. Purification and properties of the hydroxylating enzyme.
Topics: Ascorbic Acid; Chromatography, Gel; Cinnamates; Copper; Coumarins; Electrophoresis, Polyacrylamide Gel; Folic Acid; Hydroxylation; Mixed Function Oxygenases; Molecular Weight; NAD; NADP; Oxidoreductases; Phenols; Streptomyces | 1972 |
Methotrexate binding to dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.
Topics: Binding Sites; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Methotrexate; NADP; Osmolar Concentration; Oxidation-Reduction; Protein Binding; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Time Factors | 1973 |
Mutations affecting levels of tetrahydrofolate interconversion enzymes in Saccharomyces cerevisiae. I. Enzyme levels in ade3-41 and ADE15, a dominant adenine auxotroph.
Topics: Adenine; Adenosine Triphosphate; Alleles; Aminohydrolases; Coenzymes; Crosses, Genetic; Folic Acid; Formates; Genes, Dominant; Genotype; Heterozygote; Histidine; Ligases; Mutation; NADP; Operon; Oxidoreductases; Saccharomyces cerevisiae; Tetrahydrofolates; Water | 1973 |
Mutations affecting levels of tetrahydrofolate interconversion enzymes in Saccharomyces cerevisiae. II. Map positions on chromosome VII of ade3-41 and ADE15.
Topics: Adenine; Adenosine Triphosphate; Alleles; Aminohydrolases; Chromosome Mapping; Coenzymes; Crosses, Genetic; Diploidy; Folic Acid; Formates; Genes; Genes, Dominant; Genes, Recessive; Genetic Linkage; Genetics, Microbial; Heterozygote; Histidine; Ligases; Methods; Mutation; NADP; Oxidoreductases; Recombination, Genetic; Saccharomyces cerevisiae; Tetrahydrofolates; Water | 1973 |
Functions of baseplate components in bacteriophage T4 infection. I. Dihydrofolate reductase and dihydropteroylhexaglutamate.
Topics: Adsorption; Animals; Antibodies, Viral; Binding Sites, Antibody; Biological Assay; Carboxypeptidases; Coliphages; Escherichia coli; Folic Acid; Glutamates; Kidney; Lacticaseibacillus casei; Microscopy, Electron; NADP; Pronase; Sulfur Radioisotopes; Swine; Tetrahydrofolate Dehydrogenase; Trypsin; Viral Proteins | 1973 |
Conformational changes induced in dihydrofolate reductase by folates, pyridine nucleotide coenzymes, and methotrexate.
Topics: Folic Acid; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Protein Conformation; Protein Denaturation; Tetrahydrofolate Dehydrogenase; Urea | 1974 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on liver constituents associated with folate metabolism.
Topics: Adenosine Triphosphate; Animals; Azo Compounds; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Enterococcus faecalis; Female; FIGLU Test; Folic Acid; Glutarates; Lacticaseibacillus casei; Liver; Methionine; NAD; NADP; Pediococcus; Potassium; Sheep; Sodium; Tetrahydrofolates; Vitamin B 12 Deficiency | 1974 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Inhibition of 5,10-methylenetetrahydrofolate dehydrogenase by the d,L-diastereoisomer of 5,10-methylenetetrahydrofolate.
Topics: Enzymes; Escherichia coli; Folic Acid; In Vitro Techniques; Kinetics; NADP; Tetrahydrofolate Dehydrogenase | 1964 |
Purification and properties of N5, N10-Methylenetetra-hydrofolate dehydrogenase of calf thymus.
Topics: Animals; Bromides; Cattle; Chemistry Techniques, Analytical; Chloromercuribenzoates; Chromatography; Ethylmaleimide; Folic Acid; Glycerol; In Vitro Techniques; Kinetics; Mercaptoethanol; NADP; Oxidoreductases; Thymus Gland | 1965 |
Uptake of reduced folic acid by chicken liver enzyme.
Topics: Adenosine Triphosphate; Animals; Folic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Manganese; Mercaptoethanol; NADP; Poultry; Temperature | 1965 |
Tetrahydrofolate dehydrogenase from bakers' yeast.
Topics: Chromatography; Folic Acid; In Vitro Techniques; Mercaptoethanol; NAD; NADP; Saccharomyces; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1965 |
A radio-enzymatic assay for folic acid.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Paper; Folic Acid; In Vitro Techniques; Liver; NADP; Poultry; Radiometry; Tetrahydrofolate Dehydrogenase | 1965 |
Dihydrofolate reductase from the L1210R murine lymphoma. Fluorometric measurements of the interaction of the enzyme with coenzymes, substrates, and inhibitors.
Topics: Animals; Chemical Phenomena; Chemistry; Enzymes; Fluorometry; Folic Acid; Leukemia L1210; Lymphoma; Methotrexate; Mice; NADP; Triamterene | 1966 |
On the mechanism of chemical and enzymatic reduction of folate and dihydrofolate.
Topics: Chemical Phenomena; Chemistry; Deuterium; Folic Acid; NADP; Pteridines; Tetrahydrofolate Dehydrogenase; Tritium | 1966 |
[On metabolism and action mechanism of estrogens. VII. O-hydroxylation of estrone in rat liver and its relation to protein binding as well as to p-hydroxylation and to hydroxylations in aliphatic positions].
Topics: Animals; Antimetabolites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Estrone; Folic Acid; Liver; Microsomes; Mixed Function Oxygenases; NADP; Protein Binding; Rats | 1965 |
Folate cofactor biosynthesis by Plasmodium berghei. Comparison of folate and dihydrofolate as substrates.
Topics: Folic Acid; Leucovorin; NADP; Plasmodium; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 1966 |
Dihydrofolate reductase from Trypanosoma equiperdum. I. Isolation, partial purification, and properties.
Topics: Aminopterin; Animals; Folic Acid; Folic Acid Antagonists; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methotrexate; NAD; NADP; Pyrimethamine; Rats; Tetrahydrofolate Dehydrogenase; Trypanosoma | 1967 |
Purification of 5,10-methylenetetrahydrofolate dehydrogenase from Salmonella typhimurium and its inhibition by purine nucleotides.
Topics: Adenosine Triphosphate; Benzoates; Chromatography, Ion Exchange; Enzymes; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NADP; Oxidoreductases; Salmonella typhimurium | 1967 |
[On the metabolism and mechanism of action of estrogens. 8. The biogenesis and metabolism of 2-hydroxyestrone in relation to the formation of protein-bound and water soluble estrone metabolites and to NADPH oxidation in rat liver microsomes].
Topics: Aminopterin; Animals; Carbon Isotopes; Cysteine; Estrone; Female; Folic Acid; Glutathione; Humans; Kinetics; Liver; Male; Microsomes; NADP; Oxidation-Reduction; Phenylalanine; Phosphates; Protein Binding; Pteridines; Rats; Steroids | 1966 |
Dihydrofolate reductase from the L1210 R murine lymphoma. Further studies on the binding of substrates and inhibitors to the enzyme.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Fluorometry; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; NADP; Protein Binding; Pyrimidines; Tetrahydrofolate Dehydrogenase; Triamterene | 1967 |
[The cofactors of serine synthesis in primary root homogenates of Zea mays].
Topics: Adenosine Triphosphate; Biotin; Buffers; Chromatography; Electrophoresis; Folic Acid; NADP; Poaceae; Pyridoxal Phosphate; Serine; Vitamin B 12 | 1966 |
Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase.
Topics: Acetates; Ascorbic Acid; Buffers; Chemical Phenomena; Chemistry; Citrates; Edetic Acid; Folic Acid; Hydrogen-Ion Concentration; NADP; Solubility; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolate Dehydrogenase | 1967 |
Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver.
Topics: Amidohydrolases; Animals; Carbon Dioxide; Carbon Isotopes; Folic Acid; Formates; In Vitro Techniques; Liver; NADP; Oxidoreductases; Swine | 1968 |
The essential SH-groups in folate reductase.
Topics: Animals; Benzoates; Binding Sites; Chemical Phenomena; Chemistry; Culture Techniques; Folic Acid; Folic Acid Antagonists; Methotrexate; NADP; Sarcoma 180; Sulfhydryl Compounds; Temperature; Tetrahydrofolate Dehydrogenase; Urea | 1968 |
[An aminopterine-resistant enzymatic way of reduction of folic acid to a coenzymic form, discovered in plants].
Topics: Aminopterin; Chromatography; Chromatography, Gel; Coenzymes; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; NAD; NADP; Plants | 1966 |
Protection of microbial dihydrofolate reductase against inactivation by pronase.
Topics: Amines; Benzoates; Calcium; Chromatography; Endopeptidases; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Glutamates; Heterocyclic Compounds; Kinetics; Leucovorin; NAD; NADP; Protein Binding; Pteridines | 1968 |
Allosteric inhibition of TPN-linked isocitrate dehydrogenase by folate.
Topics: Animals; Folic Acid; Isocitrate Dehydrogenase; Kinetics; Myocardium; NADP; Spectrophotometry; Swine | 1968 |
Studies on dihydrofolic reductase. 3. Activation of the chicken liver enzyme by urea and thiourea.
Topics: Animals; Chickens; Folic Acid; Formamides; Glycerol; Guanidines; Hydrogen-Ion Concentration; Kinetics; Liver; NAD; NADP; Optical Rotatory Dispersion; Protein Binding; Tetrahydrofolate Dehydrogenase; Thiourea; Urea | 1968 |
Presence and properties of dihydrofolate reductases within the genus Crithidia.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; NADP; Pteridines; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trypanosoma | 1969 |
Reactions of glycine synthesis and glycine cleavage catalyzed by extracts of Arthrobacter globiformis grown on glycine.
Topics: Ammonium Chloride; Arthrobacter; Bicarbonates; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Folic Acid; Formaldehyde; Glutathione; Glycine; Ion Exchange Resins; Kinetics; Mitochondria, Liver; NAD; NADP; Pyridoxal Phosphate; Serine; Sulfhydryl Compounds | 1969 |
The hydroxylation of p-coumaric acid by an enzyme from leaves of spinach beet (Beta vulgaris L.).
Topics: Ascorbic Acid; Catechol Oxidase; Coumarins; Folic Acid; Mixed Function Oxygenases; NAD; NADP; Plants; Pteridines | 1969 |
Hydroxymethylation of the benzene ring. V. NADPH requirement for aryl hydroxymethylation by a C-1 donor bound to a macromolecule.
Topics: Animals; Ascorbic Acid; Benzene; Cell-Free System; Folic Acid; Guinea Pigs; Leucovorin; Microsomes, Liver; NADP; Phenols; Resins, Plant; Serine; Tritium; Vibration | 1970 |
[Coenzymes (vitamins)].
Topics: Ascorbic Acid; Biotin; Chemical Phenomena; Chemistry; Coenzyme A; Coenzymes; Cytochromes; Flavin-Adenine Dinucleotide; Folic Acid; Glutathione; NAD; NADP; Nucleosides; Pyridoxine; Thiamine; Thioctic Acid; Ubiquinone; Vitamins | 1970 |
"Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromatography; Enzyme Activation; Enzyme Induction; Erythrocytes; Folic Acid; Humans; Hydrogen-Ion Concentration; Immune Sera; Leukemia L1210; Leukocytes; Methotrexate; Molecular Weight; NAD; NADP; Neoplasms; Protein Denaturation; Tetrahydrofolate Dehydrogenase | 1970 |
Major pathways of glycine and serine catabolism in rat liver.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Carbon Isotopes; Chromatography, Ion Exchange; Folic Acid; Glycine; L-Serine Dehydratase; Liver; Male; Mitochondria, Liver; NADP; Oxidoreductases; Pyruvates; Rats; Serine; Spectrophotometry; Transferases | 1970 |
Interconversion of the multiple forms of dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.
Topics: Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Drug Resistance, Microbial; Electrophoresis; Fluorescence; Folic Acid; Glutathione Reductase; Hot Temperature; Hydrogen-Ion Concentration; Lactobacillus; Methotrexate; Molecular Weight; NADP; Protein Denaturation; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1971 |
Effects of x-irradiation on the various enzymic functions of NADP plus-linked isocitrate dehydrogenase.
Topics: Animals; Benzoates; Catalysis; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Ethylmaleimide; Folic Acid; Glyoxylates; Iodoacetates; Isocitrate Dehydrogenase; Kinetics; Linoleic Acids; Manganese; Methionine; Myocardium; NADP; Oxaloacetates; Peroxides; Radiation Effects; Sulfhydryl Compounds; Sulfides; Swine; Tritium | 1971 |
The metabolism of aromatic compounds in higer plants. X. Properties of the cinnamic acid 4-hydroxylase of pea seedlings and some aspects of its metabolic and developmental control.
Topics: Azides; Carbon Isotopes; Carbon Monoxide; Chelating Agents; Chromatography, Paper; Cinnamates; Cyanides; Drug Stability; Edetic Acid; Enzyme Induction; Folic Acid; Glucosephosphate Dehydrogenase; Glycerol; Hydrogen-Ion Concentration; Kinetics; Light; Mercaptoethanol; Microsomes; Mixed Function Oxygenases; NADP; Phenols; Plant Cells; Plant Development; Plants; Pyridines; Radiation Effects; Temperature; Ultracentrifugation | 1971 |
Affinity chromatography of dihydrofolate reductase.
Topics: Chromatography; Cyanogen Bromide; Electrophoresis, Disc; Folic Acid; Hydrogen-Ion Concentration; Lactobacillus; Methods; Methotrexate; NADP; Polysaccharides; Tetrahydrofolate Dehydrogenase | 1971 |
Proton magnetic resonance studies of folate and folate antagonists.
Topics: Aminopterin; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Structure-Activity Relationship; Temperature | 1971 |
Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.
Topics: Adenosine; Alcohol Oxidoreductases; Ammonium Sulfate; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Drug Stability; Flavin-Adenine Dinucleotide; Folic Acid; Formaldehyde; Homocysteine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Liver; NAD; NADP; Rats; S-Adenosylmethionine; Spectrophotometry; Swine; Vitamin K | 1971 |
L-Threonine acetaldehyde-lyase in a strain of Bacillus subtilis.
Topics: Acetates; Aldehyde-Lyases; Bacillus subtilis; Carboxy-Lyases; Chromatography, Gel; Folic Acid; Glycine; Hydrazines; Hydrogen-Ion Concentration; Isoniazid; Kinetics; L-Serine Dehydratase; NAD; NADP; Phosphoric Acids; Pyridoxal Phosphate; Serine; Stereoisomerism; Threonine; Transferases | 1971 |
Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.
Topics: Acetates; Amino Acids; Ammonium Sulfate; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Drug Resistance, Microbial; Electrophoresis; Folic Acid; Folic Acid Antagonists; Hydroxyapatites; Lacticaseibacillus casei; Lactobacillus; Methotrexate; Molecular Weight; NADP; Protein Binding; Sodium Dodecyl Sulfate; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Ultracentrifugation; Ultraviolet Rays; Urea | 1972 |
Dihydrofolate reductase. Purification and characterization of the enzyme from an amethopterin-resistant mutant of Escherichia coli.
Topics: Amino Acids; Chromatography, Affinity; Chromatography, Gel; Cyanogen Bromide; Dansyl Compounds; Drug Resistance, Microbial; Electrophoresis; Electrophoresis, Disc; Escherichia coli; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Methotrexate; NAD; NADP; Osmolar Concentration; Potassium Chloride; Sodium Chloride; Tetrahydrofolate Dehydrogenase; Ultracentrifugation | 1972 |
Purification of tetrahydrofolate dehydrogenase by affinity chromatography.
Topics: Alkylation; Ammonium Sulfate; Animals; Buffers; Cell Line; Chemical Precipitation; Chromatography, Affinity; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methods; Methotrexate; NADP; Osmolar Concentration; Polysaccharides; Protein Binding; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1972 |
Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.
Topics: Animals; Antigen-Antibody Reactions; Cell Line; Chromatography; Chromatography, Gel; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Guanidines; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred Strains; NADP; Potassium Chloride; Protein Denaturation; Pyrimidines; Spleen; Tetrahydrofolate Dehydrogenase; Triazines; Urea | 1971 |
[Dihydrofolate reductase from baker's yeast. Purification and properties].
Topics: Acetamides; Chemical Phenomena; Chemistry; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Guanidines; Hydrogen-Ion Concentration; Kinetics; Mercuribenzoates; Molecular Weight; NADP; Peptides; Saccharomyces; Tetrahydrofolate Dehydrogenase; Urea | 1972 |
Circular dichroic studies on the interaction of dihydrofolate reductase with substrates, coenzymes, and inhibitors.
Topics: Circular Dichroism; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Methotrexate; NADP; Oxidation-Reduction; Protein Binding; Streptococcus; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1972 |
[A new determination method of dihydrofolate reductase using ( 3 H) dihydrofolic acid].
Topics: Aminobenzoates; Chemical Phenomena; Chemistry; Chromatography, Paper; Folic Acid; Glutamates; Methods; NADP; Oxidation-Reduction; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tritium | 1972 |
Single-step purification of dihydrofolate reductases on pteridine matrices.
Topics: Chromatography, Affinity; Folic Acid; Methods; Molecular Weight; NADP; Pteridines; Tetrahydrofolate Dehydrogenase | 1972 |
Dihydrofolate reductases of Escherichia coli and bacteriophage Tr. A spectrofluorometric study.
Topics: Amino Acids; Binding Sites; Chlorides; Chromatography, Affinity; Coliphages; Electrophoresis, Disc; Escherichia coli; Fluorides; Folic Acid; Folic Acid Antagonists; Kinetics; Methotrexate; NADP; Osmolar Concentration; Peptides; Perchlorates; Sodium Dodecyl Sulfate; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Streptomycin; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thiocyanates | 1973 |
Circular dichroism studies in the near UV of ligand binding to chicken liver dihydrofolate reductase.
Topics: Animals; Chickens; Circular Dichroism; Folic Acid; Liver; Methotrexate; NADP; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1983 |
Preparation of (-)-5,6,7,8-tetrahydrofolate using immobilized dihydrofolate reductase.
Topics: Bacterial Proteins; Circular Dichroism; Enzymes, Immobilized; Folic Acid; NADP; Spectrophotometry, Ultraviolet; Stereoisomerism; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1984 |
Methylenetetrahydrofolate dehydrogenase - methenyltetrahydrofolate cyclohydrolase - formyltetrahydrofolate synthetase from porcine liver: evidence to support a common dehydrogenase-cyclohydrolase site.
Topics: Aminohydrolases; Animals; Binding Sites; Diethyl Pyrocarbonate; Folic Acid; Formate-Tetrahydrofolate Ligase; Kinetics; Ligases; Liver; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Multienzyme Complexes; NAD; NADP; Oxidoreductases; Phenylglyoxal; Swine | 1983 |
Photo-CIDNP studies of the influence of ligand binding on the surface accessibility of aromatic residues in dihydrofolate reductase.
Topics: Folic Acid; Histidine; Lacticaseibacillus casei; Lasers; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Photochemistry; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
13C NMR evidence for three slowly interconverting conformations of the dihydrofolate reductase-NADP+-folate complex.
Topics: Binding Sites; Folic Acid; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1981 |
Modification of tyrosine residues in dihydrofolate reductase from Lactobacillus casei.
Topics: 4-Chloro-7-nitrobenzofurazan; Enzyme Activation; Folic Acid; Kinetics; Lacticaseibacillus casei; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetranitromethane; Tyrosine | 1982 |
Inactivation of dihydrofolate reductase from Lactobacillus casei by diethyl pyrocarbonate.
Topics: Binding Sites; Diethyl Pyrocarbonate; Folic Acid; Folic Acid Antagonists; Formates; Histidine; Hydroxylamines; Lacticaseibacillus casei; NADP | 1982 |
Hydrogen-1, carbon-13, and phosphorus-31 nuclear magnetic resonance studies of the dihydrofolate reductase-nicotinamide adenine dinucleotide phosphate-folate complex: characterization of three coexisting conformational states.
Topics: Carbon Isotopes; Folic Acid; Histidine; Hydrogen; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; NADP; Phosphorus; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1982 |
Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli; Fluorescence; Folic Acid; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1981 |
Nuclear magnetic resonance study of interaction of ligands with streptococcus faecium dihydrofolate reductase labeled with [gamma-13C]tryptophan.
Topics: Adenosine Diphosphate Ribose; Carbon Isotopes; Folic Acid; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Pteroylpolyglutamic Acids; Pyrimidines; Spin Labels; Streptococcus; Tetrahydrofolate Dehydrogenase; Tryptophan | 1982 |
A simplified radioenzymatic assay for dihydrofolate reductase using [3H]dihydrofolate.
Topics: Dithionite; Folic Acid; Fractional Precipitation; Humans; Kinetics; Methods; Methotrexate; NADP; Oxidation-Reduction; Sulfates; Tetrahydrofolate Dehydrogenase; Tritium; Zinc; Zinc Sulfate | 1980 |
Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.
Topics: Base Sequence; Binding Sites; Binding, Competitive; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Methotrexate; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1994 |
Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.
Topics: Ammonium Sulfate; Catalysis; Chemical Precipitation; Enzyme Stability; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Phenylalanine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1994 |
Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.
Topics: Catalysis; Crystallization; Crystallography, X-Ray; Escherichia coli; Folic Acid; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Structure; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1994 |
Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine.
Topics: Adenosine Diphosphate; Animals; Carbon Dioxide; Folic Acid; Formates; Formyltetrahydrofolates; Male; Mitochondria, Liver; NADP; Oligomycins; Oxidation-Reduction; Propionates; Rats; Rats, Sprague-Dawley; Serine | 1993 |
Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro.
Topics: Base Sequence; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation; Humans; Methotrexate; Molecular Sequence Data; NADP; Protein Biosynthesis; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1993 |
Engineering specificity for folate into dihydrofolate reductase from Escherichia coli.
Topics: Amino Acid Sequence; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Protein Engineering; Protein Structure, Secondary; Species Specificity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1996 |
In search of dihydrofolate reductase.
Topics: Folic Acid; History, 20th Century; Leucovorin; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase | 1996 |
Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein.
Topics: Allosteric Regulation; Binding Sites; Calorimetry; Fluorescence Polarization; Folic Acid; Kinetics; Ligands; NADP; Protein Binding; Quinazolines; R Factors; Tetrahydrofolate Dehydrogenase | 1996 |
Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase.
Topics: Aminohydrolases; Animals; Chromatography, Gel; Fluorescence; Folic Acid; Formate-Tetrahydrofolate Ligase; Glycine Hydroxymethyltransferase; Kinetics; Leucovorin; Liver; Methylenetetrahydrofolate Dehydrogenase (NADP); Models, Chemical; Multienzyme Complexes; NADP; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Pteroylpolyglutamic Acids; Rabbits; Spectrophotometry | 1996 |
The influence of aspartate 26 on the tautomeric forms of folate bound to Lactobacillus casei dihydrofolate reductase.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; NADP; Point Mutation; Recombinant Proteins; Stereoisomerism; Tetrahydrofolate Dehydrogenase | 1997 |
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
Topics: Animals; Biopterins; Blotting, Western; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Leishmania major; Methotrexate; Models, Chemical; Multienzyme Complexes; NADP; Oxidoreductases; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1997 |
Inactivation kinetics of dihydrofolate reductase from Chinese hamster during urea denaturation.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Fluorometry; Folic Acid; Kinetics; Macromolecular Substances; NADP; Protein Denaturation; Protein Folding; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase; Urea | 1997 |
Folate utilization by monomeric versus heterotetrameric sarcosine oxidases.
Topics: Corynebacterium; Folic Acid; Formaldehyde; NADP; Oxidoreductases, N-Demethylating; Sarcosine Oxidase; Tetrahydrofolates | 1997 |
Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.
Topics: Animals; Biopterins; Chromatography, Gel; Cloning, Molecular; DNA Primers; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fluorescence; Folic Acid; Gene Expression; Hydrogen-Ion Concentration; Kinetics; Leishmania; Molecular Weight; NADP; Oxidation-Reduction; Oxidoreductases; Pterins; Recombinant Fusion Proteins | 1997 |
Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme.
Topics: Amino Acid Sequence; Catalysis; Codon, Terminator; Dimerization; Escherichia coli; Folic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; NADP; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1997 |
Use of 10-formyl-5,8-dideazafolate as substrate for rat 10-formyltetrahydrofolate dehydrogenase.
Topics: Acyltransferases; Animals; Folic Acid; Hydrolysis; Hydroxymethyl and Formyl Transferases; Leucovorin; Molecular Structure; NADP; Oxidoreductases Acting on CH-NH Group Donors; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Rats; Spectrophotometry; Stereoisomerism | 1997 |
Refolding of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase in the presence of ligand: a stopped-flow NMR spectroscopy study.
Topics: Circular Dichroism; Escherichia coli; Fluorine; Folic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; NADP; Protein Folding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Tryptophan | 1998 |
A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition.
Topics: Binding Sites; Calorimetry; Catalysis; Enzyme Inhibitors; Escherichia coli; Folic Acid; Glutamine; Histamine; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; NADP; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1997 |
Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Topics: Antimetabolites, Antineoplastic; Binding Sites; Crystallography, X-Ray; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Mutation; NADP; Tetrahydrofolate Dehydrogenase | 1998 |
Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
Topics: Binding Sites; Crystallography, X-Ray; Folic Acid; Ligands; Macromolecular Substances; Models, Molecular; NADP; Pneumocystis; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1999 |
NMR studies of ligand carboxylate group interactions with arginine residues in complexes of Lactobacillus casei dihydrofolate reductase with substrates and substrate analogues.
Topics: 4-Aminopyridine; Amino Acid Sequence; Arginine; Carboxylic Acids; Conserved Sequence; Folic Acid; Glutamates; Hydrogen Bonding; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Nuclear Magnetic Resonance, Biomolecular; Static Electricity; Tetrahydrofolate Dehydrogenase | 2000 |
High pressure NMR reveals active-site hinge motion of folate-bound Escherichia coli dihydrofolate reductase.
Topics: Binding Sites; Catalysis; Escherichia coli; Folic Acid; NADP; Nuclear Magnetic Resonance, Biomolecular; Pressure; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2000 |
Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase.
Topics: Folic Acid; Molecular Structure; NADP; Spectrum Analysis, Raman; Tetrahydrofolate Dehydrogenase; Vibration | 2001 |
Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo.
Topics: Amino Acid Sequence; Arabidopsis; Base Sequence; DNA Primers; Folic Acid; Genetic Complementation Test; Kinetics; Methylenetetrahydrofolate Reductase (NADPH2); Molecular Sequence Data; Mutation; NADP; Nuclear Magnetic Resonance, Biomolecular; Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Saccharomyces cerevisiae | 2002 |
Bisubstrate kinetics using SAS computer software.
Topics: Computer Graphics; Folic Acid; Kinetics; Models, Chemical; NADP; Software; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 2002 |
One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.
Topics: Algorithms; Catalytic Domain; Computer Simulation; Folic Acid; Ligands; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; NADP; Static Electricity; Tetrahydrofolate Dehydrogenase | 2001 |
Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
Topics: Animals; Binding Sites; Catalysis; Crystallization; Enzyme Stability; Fluorodeoxyuridylate; Folic Acid; Hydrocarbons; Kinetics; Leishmania major; Methane; Models, Molecular; Molecular Structure; Multienzyme Complexes; Mutagenesis, Site-Directed; NADP; Quinazolines; Spectrophotometry; Static Electricity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase | 2003 |
Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.
Topics: Bacterial Proteins; Binding Sites; Catalysis; Circular Dichroism; Cloning, Molecular; Energy Transfer; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Structure; NADP; Oxidation-Reduction; Protein Folding; Protein Structure, Quaternary; Protons; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thermotoga maritima | 2003 |
Inhibition studies of sulfonamide-containing folate analogs in yeast.
Topics: Anti-Infective Agents; Binding, Competitive; Dihydropteroate Synthase; Folic Acid; Gene Deletion; Mutation; NADP; Oxidation-Reduction; Peptide Synthases; Piperidines; Saccharomyces cerevisiae; Sulfonamides; Sulfones | 2003 |
High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.
Topics: Binding, Competitive; Drug Evaluation, Preclinical; Escherichia coli; Folic Acid; Folic Acid Antagonists; Indicators and Reagents; Models, Molecular; Molecular Conformation; NADP; Peptide Library; Tetrahydrofolate Dehydrogenase | 2003 |
Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase.
Topics: Calorimetry; Catalysis; Dimerization; Escherichia coli Proteins; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Ligands; Models, Molecular; Mutagenesis, Site-Directed; NADP; Osmolar Concentration; Protein Binding; R Factors; Sodium; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2003 |
OCCURRENCE OF TWO DIFFERENT ENZYMES IN THE SILKWORM, BOMBYX MORI, TO REDUCE FOLATE AND SEPIAPTERIN.
Topics: Animals; Bombyx; Enzymes; Folic Acid; NADP; Oxidoreductases; Pterins; Research; Xanthopterin | 1963 |
5,10-METHYLENETETRAHYDROFOLIC DEHYDROGENASE FROM BAKERS' YEAST. II. USE IN ASSAY OF TETRAHYDROFOLIC ACID.
Topics: Biological Assay; Folic Acid; Formaldehyde; NADP; Oxidoreductases; Research; Saccharomyces; Saccharomyces cerevisiae; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates | 1964 |
A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES.
Topics: Animals; Chemistry Techniques, Analytical; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Methotrexate; Mice; Microchemistry; NADP; Neoplasms; Oxidoreductases; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
STUDIES ON THE INHIBITION OF DIHYDROFOLATE REDUCTASE BY THE FOLATE ANTAGONISTS.
Topics: Animals; Carcinoma, Ehrlich Tumor; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; NADP; Neoplasms, Experimental; Oxidoreductases; Pharmacology; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
STUDIES ON THE ENZYMATIC N- AND O-DEMETHYLATION OF NARCOTIC ANALGESICS AND EVIDENCE FOR THE FORMATION OF CODEINE FROM MORPHINE IN RATS AND DOGS.
Topics: Adenosine Triphosphate; Antitussive Agents; Autoradiography; Carbon Isotopes; Chlorides; Chromatography; Codeine; Dogs; Folic Acid; Glutathione; Liver; Metabolism; Methionine; Methylation; Morphine; NADP; Narcotics; Pharmacology; Rats; Research; Urine | 1964 |
PURIFICATION AND PROPERTIES OF DIHYDROFOLATE REDUCTASE OF SHEEP LIVER.
Topics: Animals; Chromatography; Folic Acid; Liver; Methotrexate; NADP; Oxidoreductases; Pterins; Research; Sheep; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. VII. ISOLATION OF A COBALAMIN-CONTAINING TRANSMETHYLASE (5-METHYLTETRAHYDRO-FOLATE-HOMOCYSTEINE) FROM MAMMALIAN LIVER.
Topics: Animals; Chromatography; Corrinoids; Flavin-Adenine Dinucleotide; Folic Acid; Glutamates; Homocysteine; Liver; Methionine; Methyltransferases; NAD; NADP; Protamines; Research; Swine; Transferases; Vitamin B 12 | 1964 |
DIHYDROFOLATE REDUCTASE IN GENOTYPICALLY DISTINGUISHABLE AMETHOPTERIN-RESISTANT DIPLOCOCCUS PNEUMONIAE.
Topics: Folic Acid; Genotype; Hydrogen-Ion Concentration; Methotrexate; NADP; Oxidoreductases; Research; Streptococcus pneumoniae; Tetrahydrofolate Dehydrogenase | 1964 |
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
Topics: Alcohols; Aldehydes; Chromatography; Ethers; Fatty Acids; Folic Acid; Glycerol; Glyceryl Ethers; Liver; Methotrexate; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Pteridines; Pterins; Rats; Research; Stearic Acids | 1964 |
ON THE SIMILARITY OF DIHYDROFOLATE REDUCTASES FROM AMETHOPTERIN-SENSITIVE AND AMETHOPTERIN-RESISTANT MOUSE LEUKEMIA (L1210) CELLS.
Topics: Animals; Benzoates; Enzyme Inhibitors; Folic Acid; Leukemia; Leukemia, Experimental; Methotrexate; Mice; NADP; Oxidoreductases; Pharmacology; Research; Sodium Chloride; Tetrahydrofolate Dehydrogenase | 1964 |
THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES.
Topics: Aminopterin; Androsterone; Antimetabolites; Enzyme Inhibitors; Estradiol; Folic Acid; Hydrogen-Ion Concentration; Methotrexate; NAD; NADP; Oxidoreductases; Pharmacology; Phosphates; Progesterone; Research; Spectrophotometry; Testosterone | 1965 |
Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes.
Topics: Binding Sites; Carbon Isotopes; Escherichia coli Proteins; Folic Acid; Hydrogen; Models, Molecular; NADP; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Protein Structure, Secondary; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 2003 |
Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis.
Topics: Catalysis; Folic Acid; Hydrogen; Kinetics; NADP; Temperature; Tetrahydrofolate Dehydrogenase; Thermotoga maritima | 2003 |
Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase.
Topics: Amino Acids; Binding Sites; Catalysis; Computer Simulation; Deuterium; Folic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; NADP; Quantum Theory; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2003 |
Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate.
Topics: Catalysis; Chromatography, High Pressure Liquid; Folic Acid; NADP; Oxidation-Reduction; Preservation, Biological; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 2003 |
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.
Topics: Binding Sites; Deuterium; Escherichia coli Proteins; Folic Acid; Isoleucine; NADP; Nanotechnology; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thermodynamics; Threonine; Valine | 2004 |
Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate.
Topics: Escherichia coli; Folic Acid; Kinetics; Models, Biological; NADP; Tetrahydrofolate Dehydrogenase; Time Factors | 2004 |
Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
Topics: Amino Acid Sequence; Catalysis; Chlamydia trachomatis; Cloning, Molecular; Deoxyuracil Nucleotides; Drug Design; Escherichia coli; Flavins; Folic Acid; Genetic Complementation Test; Kinetics; Molecular Sequence Data; NADP; Open Reading Frames; Oxidation-Reduction; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Thymidine Monophosphate; Thymidylate Synthase | 2005 |
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
Topics: Catalytic Domain; Escherichia coli; Folic Acid; NADP; Protein Binding; Protein Conformation; Sequence Analysis, Protein; Spectrum Analysis; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2004 |
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis.
Topics: Biophysical Phenomena; Biophysics; Catalysis; Catalytic Domain; Escherichia coli; Folic Acid; Kinetics; Models, Biological; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2005 |
Ligand binding modulates the mechanical stability of dihydrofolate reductase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biophysical Phenomena; Biophysics; CHO Cells; Chromatography, Affinity; Cricetinae; Folic Acid; Folic Acid Antagonists; Humans; Ligands; Methotrexate; Microscopy, Atomic Force; NAD; NADP; Niacinamide; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Transport; Spectrophotometry; Stress, Mechanical; Tensile Strength; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2005 |
Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
Topics: Calorimetry; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Models, Molecular; NADP; Protein Conformation; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2005 |
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Folic Acid; Isoenzymes; Macromolecular Substances; Methotrexate; Models, Molecular; Molecular Sequence Data; Molecular Structure; NADP; Oxidoreductases; Protein Structure, Quaternary; Protozoan Proteins; Sequence Alignment; Trypanosoma cruzi | 2005 |
Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase.
Topics: Algorithms; Biotinylation; Catalysis; Cysteine; Escherichia coli; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Least-Squares Analysis; Models, Chemical; Mutagenesis, Site-Directed; Mutation; NADP; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Statistical Distributions; Tetrahydrofolate Dehydrogenase | 2005 |
Effects of co-operative ligand binding on protein amide NH hydrogen exchange.
Topics: Amides; Bacterial Proteins; Deuterium; Folic Acid; Hydrogen; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Ligands; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim | 2006 |
Fingerprinting DHFR in single-molecule AFM studies.
Topics: Animals; Biophysical Phenomena; Biophysics; CHO Cells; Chromatography, Affinity; Cricetinae; Cricetulus; Folic Acid; Folic Acid Antagonists; Humans; Ligands; Methotrexate; Microscopy, Atomic Force; NAD; NADP; Niacinamide; Peptide Mapping; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Transport; Spectrophotometry; Stress, Mechanical; Tensile Strength; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2006 |
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro.
Topics: Animals; Antimalarials; Drug Resistance, Microbial; Folic Acid; Kinetics; NADP; Plasmodium falciparum; Point Mutation; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 2007 |
Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases.
Topics: Aldehyde Oxidoreductases; Aldehyde Reductase; Arabidopsis; Arabidopsis Proteins; Folic Acid; Gene Expression; Gene Silencing; Isoenzymes; Magnoliopsida; NADP; Substrate Specificity | 2007 |
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Topics: Catalysis; Crystallography, X-Ray; Folic Acid; Ligands; Models, Molecular; NADP; Protein Structure, Tertiary; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2007 |
A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase.
Topics: Binding Sites; Catalysis; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Folic Acid; Folic Acid Antagonists; NADP; Osmosis; Oxidation-Reduction; Protein Structure, Quaternary; Sorbitol; Sweetening Agents; Tetrahydrofolate Dehydrogenase; Trimethoprim; Water | 2008 |
Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.
Topics: Bacterial Infections; Folic Acid; Glucosephosphate Dehydrogenase; Humans; Kinetics; NADP; Neutrophils; Oxygen Consumption; Peroxidase; Reactive Oxygen Species; Respiratory Burst; Superoxides; Thioctic Acid | 2008 |
Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate.
Topics: Antioxidants; Catechin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Gene Expression Profiling; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Models, Molecular; Molecular Structure; NADP; RNA, Messenger; Stereoisomerism; Structure-Activity Relationship; Tea; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Time Factors | 2008 |
Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations.
Topics: Binding Sites; Folic Acid; Kinetics; Ligands; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2009 |
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.
Topics: Amino Acid Sequence; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Folic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Mutant Proteins; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase | 2011 |
Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR.
Topics: Binding Sites; Escherichia coli; Folic Acid; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; NADP; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2011 |
Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.
Topics: Folic Acid; Moritella; NADP; Nuclear Magnetic Resonance, Biomolecular; Tetrahydrofolate Dehydrogenase | 2013 |
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Cell Line, Tumor; Embryonic Stem Cells; Energy Metabolism; Fatty Acids; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Glycine; Humans; Male; Metabolic Flux Analysis; Metabolic Networks and Pathways; Methotrexate; Mice; Multienzyme Complexes; NADP; Neoplasms; Protein Biosynthesis; Purines; Serine; Transferases | 2013 |
Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues.
Topics: Age Factors; Alternative Splicing; Aminohydrolases; Animals; Female; Folic Acid; Formate-Tetrahydrofolate Ligase; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Isoenzymes; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mitochondria; Multienzyme Complexes; NAD; NADP; Neural Tube; Oxidation-Reduction; Pregnancy; Rats; Substrate Specificity | 2014 |
Quantitative flux analysis reveals folate-dependent NADPH production.
Topics: Animals; Carbon; Cell Line; Cell Line, Tumor; Cytosol; Folic Acid; Glutathione; Glycine; HEK293 Cells; Humans; Isoenzymes; Leucovorin; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mitochondria; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Serine; Tetrahydrofolates | 2014 |
Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+.
Topics: Crystallography; Folic Acid; NADP; Neutrons; Tetrahydrofolate Dehydrogenase; X-Rays | 2014 |
Loop interactions during catalysis by dihydrofolate reductase from Moritella profunda.
Topics: Bacterial Proteins; Biocatalysis; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Models, Molecular; Moritella; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Protein Conformation; Species Specificity; Tetrahydrofolate Dehydrogenase | 2014 |
Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
Topics: Allosteric Regulation; Escherichia coli; Folic Acid; Kinetics; Models, Molecular; NADP; Point Mutation; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2015 |
Oxidative stress inhibits distant metastasis by human melanoma cells.
Topics: Animals; Antioxidants; Female; Folic Acid; Gene Knockdown Techniques; Humans; Male; Melanoma; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred NOD; Mice, SCID; Minor Histocompatibility Antigens; NADP; Neoplasm Metastasis; Neoplasm Transplantation; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors | 2015 |
Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase.
Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Computer Simulation; Escherichia coli; Folic Acid; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; NADP; Oxidation-Reduction; Protein Conformation; Protein Multimerization; Tetrahydrofolate Dehydrogenase | 2016 |
Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Antibodies; Carbon; Carbon Dioxide; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Malate Dehydrogenase; Mice; NADP; Oxygen Consumption; Pentose Phosphate Pathway; RNA, Small Interfering; Succinates | 2016 |
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
Topics: Aminoimidazole Carboxamide; Carbon; Cell Compartmentation; Cell Proliferation; Colonic Neoplasms; CRISPR-Cas Systems; Cytosol; Folic Acid; Formates; Gene Knockout Techniques; Gene Library; Glycine; Glycine Hydroxymethyltransferase; HCT116 Cells; HEK293 Cells; Humans; Leucovorin; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Mutation; NADP; Ribonucleotides; Serine; Xenograft Model Antitumor Assays | 2016 |
Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.
Topics: Bacterial Proteins; Catalytic Domain; Escherichia coli; Folic Acid; Gene Expression; Hydrogen-Ion Concentration; Kinetics; NADP; Oxidation-Reduction; Protein Folding; Protein Structure, Secondary; Protons; Species Specificity; Temperature; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thermodynamics; Thermotoga maritima | 2017 |
The role of the Met
Topics: Amino Acid Substitution; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Databases, Protein; Energy Transfer; Escherichia coli; Escherichia coli Proteins; Folic Acid; Kinetics; Ligands; Methionine; Models, Molecular; Molecular Docking Simulation; Mutation; NADP; Protein Conformation; Protein Structure, Secondary; Quantum Theory; Tetrahydrofolate Dehydrogenase | 2017 |
Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.
Topics: Arabidopsis; Arabidopsis Proteins; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Homeostasis; Isoenzymes; Mutation; NADP; Oxidation-Reduction; Phylogeny; Plants, Genetically Modified; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2017 |
High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Folic Acid; Kinetics; Models, Molecular; NADP; Pressure; Protein Conformation; Tetrahydrofolate Dehydrogenase | 2018 |
NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.
Topics: Cytosol; Folic Acid; Glucosephosphate Dehydrogenase; HCT116 Cells; Homeostasis; Humans; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway | 2019 |
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Topics: Aminohydrolases; B-Lymphocytes; Cell Transformation, Viral; Epstein-Barr Virus Infections; Epstein-Barr Virus Nuclear Antigens; Female; Folic Acid; Glycolysis; HEK293 Cells; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Multifunctional Enzymes; NADP; Oxidation-Reduction; Proteome; Proto-Oncogene Proteins c-myc; Serine | 2019 |
The role of MTHFDL in mediating intracellular lipogenesis in oleaginous
Topics: DNA, Fungal; Folic Acid; Gene Expression Regulation, Fungal; Gene Knockdown Techniques; Lipid Metabolism; Lipogenesis; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Mortierella; NADP; Oxidation-Reduction | 2020 |
Mitochondrial NADP(H) generation is essential for proline biosynthesis.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Collagen; Culture Media; Cytosol; Female; Folic Acid; Gene Knockout Techniques; Glutamic Acid; Glutathione; Humans; Metabolome; Mice; Mice, Nude; Mitochondria; Mitochondrial Proteins; NADP; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Proline | 2021 |
Serine catabolism generates liver NADPH and supports hepatic lipogenesis.
Topics: Acetyl Coenzyme A; Adipose Tissue; Aminohydrolases; Animals; Fatty Acids; Female; Folic Acid; Formate-Tetrahydrofolate Ligase; Glutamine; Glycine Hydroxymethyltransferase; Hepatocytes; Lipid Metabolism; Lipogenesis; Liver; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Multienzyme Complexes; NADP; Oxidative Phosphorylation; Oxidoreductases Acting on CH-NH Group Donors; Serine | 2021 |
Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP
Topics: Biopterins; Crystallography, X-Ray; Folic Acid; Leishmania major; NADP; Oxidoreductases | 2022 |
Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate.
Topics: Animals; Elephantiasis, Filarial; Folic Acid; Folic Acid Antagonists; Molecular Docking Simulation; NADP; Tetrahydrofolate Dehydrogenase; Wuchereria bancrofti | 2023 |
Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase.
Topics: Adenine; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Models, Molecular; NAD; NADP; Neisseria meningitidis | 2023 |