Page last updated: 2024-08-22

fluorine and proline

fluorine has been researched along with proline in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (35.90)	18.7374
1990's	1 (2.56)	18.2507
2000's	10 (25.64)	29.6817
2010's	12 (30.77)	24.3611
2020's	2 (5.13)	2.80

Authors

Authors	Studies
Diegelmann, RF; Katz, E; Ondrejickova, O	1
Iwase, H; Murai, A	1
Shotton, DM; Watson, HC; White, NJ	1
Mustakallio, KK; Teir, H; Uitto, J	1
Gerig, JT; McLeod, RS	1
Griffin, DH; Timberlake, WE	1
Cunningham, WD; Ohnishi, T; Urry, DW	1
Mitchell, LW; Onishi, T; Urry, DW	1
Prockop, DJ; Takeuchi, T	1
Torchia, DA	1
Goldman, P; Unkeless, JC	1
Faulstich, H; Goodman, M; Naider, F; Patel, DJ; Tonelli, AE; Wieland, T	1
Blout, ER; Doyle, BB; Lorenzi, GP; Traub, W	1
Bakerman, S; Burgstahler, AW; Hayden, JW; Martin, RL	1
Bretscher, LE; Holmgren, SK; Raines, RT; Taylor, KM	1
Jenkins, CL; Raines, RT	1
Bann, JG; Frieden, C	1
Bahmanyar, S; Chen, L; Harrison, KE; Kim, YM; Kucera, DJ; Scott, JM; Yazbeck, D	1
Frieden, C; Li, H	1
Braun, C; Owens, NW; Schweizer, F	1
Bae, JH; Budisa, N; Hess, P; Moroder, L; Steiner, T; Wiltschi, B	1
Arasappan, A; Bogen, S; Girijavallabhan, V; Njoroge, FG; Padilla, A; Pan, W; Ruan, S; Saksena, AK	1
Afonin, S; Komarov, IV; Mykhailiuk, PK; Palamarchuk, GV; Shishkin, OV; Ulrich, AS	1
Enders, D; Hüttl, MR; Niemeier, O	1
Del Valle, JR; Goodman, M	1
Barbeau, O; Brigaud, T; Chaume, G; Lesot, P	1
Dérien, S; Dixneuf, PH; Eckert, M; Monnier, F; Moulin, S; Osipov, SN; Roisnel, T; Titanyuk, ID	1
Tressler, CM; Zondlo, NJ	1
Horng, JC; Lin, YJ	1
Budisa, N; Dietz, D; Kubyshkin, V	1
Doud, EH; Juncosa, JI; Kelleher, NL; Lee, H; Liu, D; Sanishvili, R; Silverman, RB; Wu, R	1
Afonin, S; Budisa, N; Kara, S; Kubyshkin, V; Mykhailiuk, PK; Ulrich, AS	1
Alrowhani, W; Altiti, AS; Bachan, S; Mootoo, DR	1
Bernier, MC; Chamot-Rooke, J; Wysocki, VH	1
Calle, LP; Espinosa, JF	1
Brigaud, T; Chaume, G; Lensen, N; Miclet, E; Pytkowicz, J; Simon, J	1
Myers, EL; Palte, MJ; Raines, RT	1
Adak, A; Barman, S; Das, G; Ghosh, S; Jana, B; Mukherjee, N; Roy, R	1
Ali, A; Chan, ET; Hedger, AK; Henes, M; Kosovrasti, K; Kurt Yilmaz, N; Matthew, AN; Nageswara Rao, D; Schiffer, CA; Timm, J; Vo, SV; Zephyr, J	1

Reviews

3 review(s) available for fluorine and proline

Article	Year
Insights on the conformational stability of collagen. Natural product reports, 2002, Volume: 19, Issue:1 Topics: Amino Acid Sequence; Amino Acids; Collagen; Fluorine; Humans; Hydroxyproline; Molecular Mimicry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptoids; Proline; Protein Conformation; X-Ray Diffraction	2002
Biomimetic organocatalytic C-C-bond formations. Ernst Schering Foundation symposium proceedings, 2007, Issue:2 Topics: Aldehydes; Biomimetics; Carbon; Catalysis; Chemistry, Organic; Enzymes; Fluorine; Ketones; Models, Chemical; Models, Molecular; Molecular Conformation; Proline; Stereoisomerism	2007
γ-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state (19)F-NMR peptide studies. Organic & biomolecular chemistry, 2015, Mar-21, Volume: 13, Issue:11 Topics: Anti-Bacterial Agents; Fluorine; Gramicidin; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Proline	2015

Other Studies

36 other study(ies) available for fluorine and proline

Article	Year
Oxyngen-18 and fluoroproline studies on the synthesis of hydroxyproline and oxoproline in actinomycin. Archives of biochemistry and biophysics, 1969, Volume: 131, Issue:1 Topics: Bacteriological Techniques; Chromatography, Ion Exchange; Chromatography, Paper; Dactinomycin; Fluorine; Hydroxyproline; Methods; Models, Biological; Oxygen Consumption; Oxygen Isotopes; Proline; Pyrrolidines; Spectrum Analysis; Stereoisomerism; Streptomyces; Tritium; Water	1969
Resolution of racemic amino acids by gas chromatography. II. N-perfluoroacyl-L-prolyl derivatives. Chemical & pharmaceutical bulletin, 1974, Volume: 22, Issue:7 Topics: Amino Acids; Chemical Phenomena; Chemistry; Chromatography, Gas; Fluorine; Proline; Stereoisomerism	1974
Conformational changes and inhibitor binding at the active site of elastase. Cold Spring Harbor symposia on quantitative biology, 1972, Volume: 36 Topics: Alanine; Animals; Benzoates; Binding Sites; Crystallization; Fluorine; Glutathione; Hydrogen-Ion Concentration; Hydrolysis; Iodine; Lysine; Methanol; Molecular Conformation; Pancreas; Pancreatic Elastase; Peptides; Phenylalanine; Proline; Protein Binding; Protein Conformation; Structure-Activity Relationship; Sulfonic Acids; Swine; Tosyl Compounds; X-Ray Diffraction	1972
Corticosteroid-induced inhibition of the biosynthesis of human skin collagen. Biochemical pharmacology, 1972, Aug-15, Volume: 21, Issue:16 Topics: Acetates; Administration, Topical; Anti-Inflammatory Agents; Betamethasone; Carbon Isotopes; Chlorine; Collagen; Cycloheximide; Dialysis; Flumethasone; Fluocinolone Acetonide; Fluorine; Glucocorticoids; Humans; Hydrocortisone; Hydroxyproline; In Vitro Techniques; Prednisolone; Proline; Skin; Time Factors	1972
Conformations of cis- and trans-4-fluoro-L-proline in aqueous solution. Journal of the American Chemical Society, 1973, Aug-22, Volume: 95, Issue:17 Topics: Fluorine; Magnetic Resonance Spectroscopy; Molecular Conformation; Proline	1973
Direct inhibition of the uptake of proline by cycloheximide. Biochemical and biophysical research communications, 1973, Sep-05, Volume: 54, Issue:1 Topics: Alkaline Phosphatase; Biological Transport; Cycloheximide; Fluorine; Fungal Proteins; Fungi; Kinetics; Phenylalanine; Proline; Puromycin; Time Factors; Tritium	1973
Studies on the conformation and interactions of elastin. Proton magnetic resonance of the repeating pentapeptide. Biochemistry, 1974, Jan-29, Volume: 13, Issue:3 Topics: Amino Acid Sequence; Elastin; Ethanol; Fluorine; Glycine; Magnetic Resonance Spectroscopy; Methanol; Models, Chemical; Oligopeptides; Peptides; Proline; Protein Conformation; Protons; Temperature; Valine	1974
Solvent dependence of peptide carbonyl carbon chemical shifts and polypeptide secondary structure: the repeat tetrapeptide of elastin. Biochemical and biophysical research communications, 1974, Jul-10, Volume: 59, Issue:1 Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Carbon Isotopes; Deuterium; Dimethyl Sulfoxide; Elastin; Ethanol; Fluorine; Glycine; Magnetic Resonance Spectroscopy; Methanol; Peptides; Proline; Protein Binding; Protein Conformation; Solvents; Temperature; Valine	1974
Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen. Biochimica et biophysica acta, 1969, Feb-04, Volume: 175, Issue:1 Topics: Amino Acids; Animals; Carbon Isotopes; Cartilage; Chick Embryo; Collagen; Escherichia coli; Fluorine; Kinetics; Lysine; Mixed Function Oxygenases; Proline	1969
Evidence for cis peptide bonds in copolypeptides of glycine and proline. Biochemistry, 1972, Apr-11, Volume: 11, Issue:8 Topics: Deuterium; Dimethyl Sulfoxide; Ethanol; Fluorine; Glycine; Isomerism; Magnetic Resonance Spectroscopy; Peptides; Proline; Protein Conformation; Stereoisomerism; Temperature; Thermodynamics	1972
The diastereomers of -fluoroglutamate: complementary structural analogues. Molecular pharmacology, 1971, Volume: 7, Issue:3 Topics: Alcohols; Animals; Carboxypeptidases; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Fluorine; Glutamate Dehydrogenase; Glutamates; Glutamine; Hydro-Lyases; Kinetics; Leucyl Aminopeptidase; Ligases; Liver; Methods; Proline; Spectrophotometry; Stereoisomerism; Ultraviolet Rays	1971
Experimental and calculated conformational characteristics of the cyclic decapeptide antamanide. Biochemistry, 1971, Aug-17, Volume: 10, Issue:17 Topics: 1-Propanol; Alanine; Chemical Phenomena; Chemistry, Physical; Chloroform; Circular Dichroism; Deuterium; Dioxins; Ethanol; Fluorine; Magnetic Resonance Spectroscopy; Mathematics; Methanol; Models, Chemical; Models, Structural; Peptides; Peptides, Cyclic; Phenylalanine; Proline; Protein Conformation; Ultraviolet Rays; Valine	1971
Conformational investigations on the polypeptide and oligopeptides with the repeating sequence L-alanyl-L-prolylglycine. Biochemistry, 1971, Aug-03, Volume: 10, Issue:16 Topics: 1-Propanol; Alanine; Circular Dichroism; Collagen; Ethanol; Fluorine; Glycine; Glycols; Infrared Rays; Models, Structural; Peptides; Proline; Protein Conformation; Solvents; Spectrophotometry; Ultraviolet Rays; X-Ray Diffraction	1971
In vitro studies with fluoroprolines. Nature, 1966, Nov-19, Volume: 212, Issue:5064 Topics: Animals; Body Weight; Carbon Isotopes; Female; Fluorine; Glycine; Leucine; Liver; Mice; Proline; Protein Biosynthesis	1966
A hyperstable collagen mimic. Chemistry & biology, 1999, Volume: 6, Issue:2 Topics: Collagen; Fluorine; Hot Temperature; Hydrogen Bonding; Molecular Mimicry; Proline; Protein Conformation	1999
Folding and domain-domain interactions of the chaperone PapD measured by 19F NMR. Biochemistry, 2004, Nov-02, Volume: 43, Issue:43 Topics: Circular Dichroism; Escherichia coli Proteins; Fluorine; Kinetics; Models, Molecular; Molecular Chaperones; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; p-Fluorophenylalanine; Peptide Fragments; Periplasmic Proteins; Phenylalanine; Proline; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Stereoisomerism; Urea	2004
Fluorination-free synthesis of a 4,4-difluoro-3,3-dimethylproline derivative. The Journal of organic chemistry, 2006, Jul-21, Volume: 71, Issue:15 Topics: Catalysis; Fluorine; Molecular Structure; Proline; Stereoisomerism	2006
Comparison of C40/82A and P27A C40/82A barstar mutants using 19F NMR. Biochemistry, 2007, Apr-10, Volume: 46, Issue:14 Topics: Bacterial Proteins; Dose-Response Relationship, Drug; Fluorine; Hydrophobic and Hydrophilic Interactions; Motion; Mutation; Nuclear Magnetic Resonance, Biomolecular; Phenylalanine; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Temperature; Tryptophan; Ultracentrifugation; Urea	2007
Tuning of the prolyl trans/cis-amide rotamer population by use of C-glucosylproline hybrids. The Journal of organic chemistry, 2007, Jun-22, Volume: 72, Issue:13 Topics: Amides; Carboxylic Acids; Ethers; Fluorine; Glucose; Glycosylation; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Proline; Solvents; Stereoisomerism	2007
Synthetic biology of proteins: tuning GFPs folding and stability with fluoroproline. PloS one, 2008, Feb-27, Volume: 3, Issue:2 Topics: Drug Stability; Fluorine; Green Fluorescent Proteins; Isomerism; Molecular Conformation; Proline; Protein Folding; Proteins	2008
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034. Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14 Topics: Area Under Curve; Chemistry, Pharmaceutical; Drug Design; Fluorine; Hepatitis C; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Molecular Conformation; Proline; Serine Proteinase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Viral Nonstructural Proteins	2008
Synthesis of trifluoromethyl-substituted proline analogues as 19F NMR labels for peptides in the polyproline II conformation. Angewandte Chemie (International ed. in English), 2008, Volume: 47, Issue:31 Topics: Circular Dichroism; Fluorine; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proline; Protein Conformation	2008
Stereoselective synthesis of Boc-protected cis and trans-4-trifluoromethylprolines by asymmetric hydrogenation reactions. Angewandte Chemie (International ed. in English), 2002, May-03, Volume: 41, Issue:9 Topics: Fluorine; Hydrogenation; Methylation; Models, Molecular; Proline; Stereoisomerism	2002
Synthesis of 2-trifluoromethyl-1,3-oxazolidines as hydrolytically stable pseudoprolines. The Journal of organic chemistry, 2010, Jun-18, Volume: 75, Issue:12 Topics: Acylation; Esters; Fluorine; Methane; Molecular Structure; Oxazoles; Proline; Thiazoles	2010
Ruthenium-catalysed synthesis of fluorinated bicyclic amino esters through tandem carbene addition/cyclopropanation of enynes. Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Aug-16, Volume: 17, Issue:34 Topics: Alkynes; Amines; Bridged Bicyclo Compounds; Catalysis; Chemistry, Pharmaceutical; Cyclization; Drug Discovery; Esters; Fluorine; Halogenation; Magnetic Resonance Spectroscopy; Methane; Molecular Structure; Organometallic Compounds; Peptidomimetics; Proline; Ruthenium; Stereoisomerism	2011
(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR. The Journal of organic chemistry, 2014, Jun-20, Volume: 79, Issue:12 Topics: Amino Acids; Fluorine; Magnetic Resonance Spectroscopy; Molecular Conformation; Peptides; Proline; Protein Conformation; Stereoisomerism	2014
Impacts of terminal (4R)-fluoroproline and (4S)-fluoroproline residues on polyproline conformation. Amino acids, 2014, Volume: 46, Issue:10 Topics: Amino Acid Sequence; Circular Dichroism; Fluorine; Halogenation; Kinetics; Models, Molecular; Oligopeptides; Peptides; Proline; Protein Conformation; Protein Folding; Protein Stability; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Thermodynamics	2014
Applying γ-substituted prolines in the foldon peptide: polarity contradicts preorganization. Chembiochem : a European journal of chemical biology, 2015, Feb-09, Volume: 16, Issue:3 Topics: Amino Acid Sequence; Circular Dichroism; Fluorine; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proline; Protein Conformation; Protein Engineering; Protein Folding	2015
Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115). Journal of the American Chemical Society, 2015, Feb-25, Volume: 137, Issue:7 Topics: 4-Aminobutyrate Transaminase; Enzyme Activation; Enzyme Inhibitors; Fluorine; Humans; Models, Molecular; Proline; Protein Conformation; Pyridoxal Phosphate	2015
An organocatalytic strategy for the stereoselective synthesis of C-galactosides with fluorine at the pseudoanomeric carbon. Organic & biomolecular chemistry, 2015, Nov-07, Volume: 13, Issue:41 Topics: Aldehydes; Carbon; Catalysis; Crystallography, X-Ray; Fluorine; Galactosides; Models, Molecular; Molecular Conformation; Proline; Stereoisomerism	2015
R vs. S fluoroproline ring substitution: trans/cis effects on the formation of b2 ions in gas-phase peptide fragmentation. Physical chemistry chemical physics : PCCP, 2016, Jan-21, Volume: 18, Issue:3 Topics: Fluorine; Gases; Peptides; Proline; Stereoisomerism	2016
An improved Magnetic resonance in chemistry : MRC, 2017, Volume: 55, Issue:4 Topics: Animals; Benzamides; Benzamidines; Cattle; Fluorine; Ligands; Magnetic Resonance Spectroscopy; Proline; Protein Binding; Trypsin; Trypsin Inhibitors	2017
Homochiral versus Heterochiral Trifluoromethylated Pseudoproline Containing Dipeptides: A Powerful Tool to Switch the Prolyl-Amide Bond Conformation. The Journal of organic chemistry, 2017, 12-15, Volume: 82, Issue:24 Topics: Amides; Dipeptides; Fluorine; Methylation; Molecular Structure; Proline; Stereoisomerism; Thiazoles	2017
Catalysis of Hydrogen-Deuterium Exchange Reactions by 4-Substituted Proline Derivatives. The Journal of organic chemistry, 2019, 02-01, Volume: 84, Issue:3 Topics: Anions; Catalysis; Deuterium; Fluorine; Hydrogen; Isomerism; Ketones; Kinetics; Proline	2019
Fluorine Substituted Proline Enhances the Tubulin Binding Potential of a Tetrapeptide at the GTP Binding Pocket Causing the Inhibition of Microtubule Motility and an Antimitotic Effect. The journal of physical chemistry. B, 2021, 08-12, Volume: 125, Issue:31 Topics: Antimitotic Agents; Binding Sites; Fluorine; Guanosine Triphosphate; Microtubules; Proline; Tubulin	2021
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance. Journal of molecular biology, 2022, 05-15, Volume: 434, Issue:9 Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Design; Drug Resistance, Viral; Fluorine; Halogenation; HCV NS3-4A Protease Inhibitors; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sulfonamides; Viral Proteases	2022