fluorine and proline
fluorine has been researched along with proline in 39 studies
Research
Studies (39)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (35.90) | 18.7374 |
| 1990's | 1 (2.56) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 12 (30.77) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Diegelmann, RF; Katz, E; Ondrejickova, O | 1 |
| Iwase, H; Murai, A | 1 |
| Shotton, DM; Watson, HC; White, NJ | 1 |
| Mustakallio, KK; Teir, H; Uitto, J | 1 |
| Gerig, JT; McLeod, RS | 1 |
| Griffin, DH; Timberlake, WE | 1 |
| Cunningham, WD; Ohnishi, T; Urry, DW | 1 |
| Mitchell, LW; Onishi, T; Urry, DW | 1 |
| Prockop, DJ; Takeuchi, T | 1 |
| Torchia, DA | 1 |
| Goldman, P; Unkeless, JC | 1 |
| Faulstich, H; Goodman, M; Naider, F; Patel, DJ; Tonelli, AE; Wieland, T | 1 |
| Blout, ER; Doyle, BB; Lorenzi, GP; Traub, W | 1 |
| Bakerman, S; Burgstahler, AW; Hayden, JW; Martin, RL | 1 |
| Bretscher, LE; Holmgren, SK; Raines, RT; Taylor, KM | 1 |
| Jenkins, CL; Raines, RT | 1 |
| Bann, JG; Frieden, C | 1 |
| Bahmanyar, S; Chen, L; Harrison, KE; Kim, YM; Kucera, DJ; Scott, JM; Yazbeck, D | 1 |
| Frieden, C; Li, H | 1 |
| Braun, C; Owens, NW; Schweizer, F | 1 |
| Bae, JH; Budisa, N; Hess, P; Moroder, L; Steiner, T; Wiltschi, B | 1 |
| Arasappan, A; Bogen, S; Girijavallabhan, V; Njoroge, FG; Padilla, A; Pan, W; Ruan, S; Saksena, AK | 1 |
| Afonin, S; Komarov, IV; Mykhailiuk, PK; Palamarchuk, GV; Shishkin, OV; Ulrich, AS | 1 |
| Enders, D; Hüttl, MR; Niemeier, O | 1 |
| Del Valle, JR; Goodman, M | 1 |
| Barbeau, O; Brigaud, T; Chaume, G; Lesot, P | 1 |
| Dérien, S; Dixneuf, PH; Eckert, M; Monnier, F; Moulin, S; Osipov, SN; Roisnel, T; Titanyuk, ID | 1 |
| Tressler, CM; Zondlo, NJ | 1 |
| Horng, JC; Lin, YJ | 1 |
| Budisa, N; Dietz, D; Kubyshkin, V | 1 |
| Doud, EH; Juncosa, JI; Kelleher, NL; Lee, H; Liu, D; Sanishvili, R; Silverman, RB; Wu, R | 1 |
| Afonin, S; Budisa, N; Kara, S; Kubyshkin, V; Mykhailiuk, PK; Ulrich, AS | 1 |
| Alrowhani, W; Altiti, AS; Bachan, S; Mootoo, DR | 1 |
| Bernier, MC; Chamot-Rooke, J; Wysocki, VH | 1 |
| Calle, LP; Espinosa, JF | 1 |
| Brigaud, T; Chaume, G; Lensen, N; Miclet, E; Pytkowicz, J; Simon, J | 1 |
| Myers, EL; Palte, MJ; Raines, RT | 1 |
| Adak, A; Barman, S; Das, G; Ghosh, S; Jana, B; Mukherjee, N; Roy, R | 1 |
| Ali, A; Chan, ET; Hedger, AK; Henes, M; Kosovrasti, K; Kurt Yilmaz, N; Matthew, AN; Nageswara Rao, D; Schiffer, CA; Timm, J; Vo, SV; Zephyr, J | 1 |
Reviews
3 review(s) available for fluorine and proline
| Article | Year |
|---|---|
Insights on the conformational stability of collagen.
Topics: Amino Acid Sequence; Amino Acids; Collagen; Fluorine; Humans; Hydroxyproline; Molecular Mimicry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptoids; Proline; Protein Conformation; X-Ray Diffraction | 2002 |
Biomimetic organocatalytic C-C-bond formations.
Topics: Aldehydes; Biomimetics; Carbon; Catalysis; Chemistry, Organic; Enzymes; Fluorine; Ketones; Models, Chemical; Models, Molecular; Molecular Conformation; Proline; Stereoisomerism | 2007 |
γ-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state (19)F-NMR peptide studies.
Topics: Anti-Bacterial Agents; Fluorine; Gramicidin; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Proline | 2015 |
Other Studies
36 other study(ies) available for fluorine and proline
| Article | Year |
|---|---|
Oxyngen-18 and fluoroproline studies on the synthesis of hydroxyproline and oxoproline in actinomycin.
Topics: Bacteriological Techniques; Chromatography, Ion Exchange; Chromatography, Paper; Dactinomycin; Fluorine; Hydroxyproline; Methods; Models, Biological; Oxygen Consumption; Oxygen Isotopes; Proline; Pyrrolidines; Spectrum Analysis; Stereoisomerism; Streptomyces; Tritium; Water | 1969 |
Resolution of racemic amino acids by gas chromatography. II. N-perfluoroacyl-L-prolyl derivatives.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chromatography, Gas; Fluorine; Proline; Stereoisomerism | 1974 |
Conformational changes and inhibitor binding at the active site of elastase.
Topics: Alanine; Animals; Benzoates; Binding Sites; Crystallization; Fluorine; Glutathione; Hydrogen-Ion Concentration; Hydrolysis; Iodine; Lysine; Methanol; Molecular Conformation; Pancreas; Pancreatic Elastase; Peptides; Phenylalanine; Proline; Protein Binding; Protein Conformation; Structure-Activity Relationship; Sulfonic Acids; Swine; Tosyl Compounds; X-Ray Diffraction | 1972 |
Corticosteroid-induced inhibition of the biosynthesis of human skin collagen.
Topics: Acetates; Administration, Topical; Anti-Inflammatory Agents; Betamethasone; Carbon Isotopes; Chlorine; Collagen; Cycloheximide; Dialysis; Flumethasone; Fluocinolone Acetonide; Fluorine; Glucocorticoids; Humans; Hydrocortisone; Hydroxyproline; In Vitro Techniques; Prednisolone; Proline; Skin; Time Factors | 1972 |
Conformations of cis- and trans-4-fluoro-L-proline in aqueous solution.
Topics: Fluorine; Magnetic Resonance Spectroscopy; Molecular Conformation; Proline | 1973 |
Direct inhibition of the uptake of proline by cycloheximide.
Topics: Alkaline Phosphatase; Biological Transport; Cycloheximide; Fluorine; Fungal Proteins; Fungi; Kinetics; Phenylalanine; Proline; Puromycin; Time Factors; Tritium | 1973 |
Studies on the conformation and interactions of elastin. Proton magnetic resonance of the repeating pentapeptide.
Topics: Amino Acid Sequence; Elastin; Ethanol; Fluorine; Glycine; Magnetic Resonance Spectroscopy; Methanol; Models, Chemical; Oligopeptides; Peptides; Proline; Protein Conformation; Protons; Temperature; Valine | 1974 |
Solvent dependence of peptide carbonyl carbon chemical shifts and polypeptide secondary structure: the repeat tetrapeptide of elastin.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Carbon Isotopes; Deuterium; Dimethyl Sulfoxide; Elastin; Ethanol; Fluorine; Glycine; Magnetic Resonance Spectroscopy; Methanol; Peptides; Proline; Protein Binding; Protein Conformation; Solvents; Temperature; Valine | 1974 |
Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen.
Topics: Amino Acids; Animals; Carbon Isotopes; Cartilage; Chick Embryo; Collagen; Escherichia coli; Fluorine; Kinetics; Lysine; Mixed Function Oxygenases; Proline | 1969 |
Evidence for cis peptide bonds in copolypeptides of glycine and proline.
Topics: Deuterium; Dimethyl Sulfoxide; Ethanol; Fluorine; Glycine; Isomerism; Magnetic Resonance Spectroscopy; Peptides; Proline; Protein Conformation; Stereoisomerism; Temperature; Thermodynamics | 1972 |
The diastereomers of -fluoroglutamate: complementary structural analogues.
Topics: Alcohols; Animals; Carboxypeptidases; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Fluorine; Glutamate Dehydrogenase; Glutamates; Glutamine; Hydro-Lyases; Kinetics; Leucyl Aminopeptidase; Ligases; Liver; Methods; Proline; Spectrophotometry; Stereoisomerism; Ultraviolet Rays | 1971 |
Experimental and calculated conformational characteristics of the cyclic decapeptide antamanide.
Topics: 1-Propanol; Alanine; Chemical Phenomena; Chemistry, Physical; Chloroform; Circular Dichroism; Deuterium; Dioxins; Ethanol; Fluorine; Magnetic Resonance Spectroscopy; Mathematics; Methanol; Models, Chemical; Models, Structural; Peptides; Peptides, Cyclic; Phenylalanine; Proline; Protein Conformation; Ultraviolet Rays; Valine | 1971 |
Conformational investigations on the polypeptide and oligopeptides with the repeating sequence L-alanyl-L-prolylglycine.
Topics: 1-Propanol; Alanine; Circular Dichroism; Collagen; Ethanol; Fluorine; Glycine; Glycols; Infrared Rays; Models, Structural; Peptides; Proline; Protein Conformation; Solvents; Spectrophotometry; Ultraviolet Rays; X-Ray Diffraction | 1971 |
In vitro studies with fluoroprolines.
Topics: Animals; Body Weight; Carbon Isotopes; Female; Fluorine; Glycine; Leucine; Liver; Mice; Proline; Protein Biosynthesis | 1966 |
A hyperstable collagen mimic.
Topics: Collagen; Fluorine; Hot Temperature; Hydrogen Bonding; Molecular Mimicry; Proline; Protein Conformation | 1999 |
Folding and domain-domain interactions of the chaperone PapD measured by 19F NMR.
Topics: Circular Dichroism; Escherichia coli Proteins; Fluorine; Kinetics; Models, Molecular; Molecular Chaperones; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; p-Fluorophenylalanine; Peptide Fragments; Periplasmic Proteins; Phenylalanine; Proline; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Stereoisomerism; Urea | 2004 |
Fluorination-free synthesis of a 4,4-difluoro-3,3-dimethylproline derivative.
Topics: Catalysis; Fluorine; Molecular Structure; Proline; Stereoisomerism | 2006 |
Comparison of C40/82A and P27A C40/82A barstar mutants using 19F NMR.
Topics: Bacterial Proteins; Dose-Response Relationship, Drug; Fluorine; Hydrophobic and Hydrophilic Interactions; Motion; Mutation; Nuclear Magnetic Resonance, Biomolecular; Phenylalanine; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Temperature; Tryptophan; Ultracentrifugation; Urea | 2007 |
Tuning of the prolyl trans/cis-amide rotamer population by use of C-glucosylproline hybrids.
Topics: Amides; Carboxylic Acids; Ethers; Fluorine; Glucose; Glycosylation; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Proline; Solvents; Stereoisomerism | 2007 |
Synthetic biology of proteins: tuning GFPs folding and stability with fluoroproline.
Topics: Drug Stability; Fluorine; Green Fluorescent Proteins; Isomerism; Molecular Conformation; Proline; Protein Folding; Proteins | 2008 |
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.
Topics: Area Under Curve; Chemistry, Pharmaceutical; Drug Design; Fluorine; Hepatitis C; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Molecular Conformation; Proline; Serine Proteinase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Viral Nonstructural Proteins | 2008 |
Synthesis of trifluoromethyl-substituted proline analogues as 19F NMR labels for peptides in the polyproline II conformation.
Topics: Circular Dichroism; Fluorine; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proline; Protein Conformation | 2008 |
Stereoselective synthesis of Boc-protected cis and trans-4-trifluoromethylprolines by asymmetric hydrogenation reactions.
Topics: Fluorine; Hydrogenation; Methylation; Models, Molecular; Proline; Stereoisomerism | 2002 |
Synthesis of 2-trifluoromethyl-1,3-oxazolidines as hydrolytically stable pseudoprolines.
Topics: Acylation; Esters; Fluorine; Methane; Molecular Structure; Oxazoles; Proline; Thiazoles | 2010 |
Ruthenium-catalysed synthesis of fluorinated bicyclic amino esters through tandem carbene addition/cyclopropanation of enynes.
Topics: Alkynes; Amines; Bridged Bicyclo Compounds; Catalysis; Chemistry, Pharmaceutical; Cyclization; Drug Discovery; Esters; Fluorine; Halogenation; Magnetic Resonance Spectroscopy; Methane; Molecular Structure; Organometallic Compounds; Peptidomimetics; Proline; Ruthenium; Stereoisomerism | 2011 |
(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR.
Topics: Amino Acids; Fluorine; Magnetic Resonance Spectroscopy; Molecular Conformation; Peptides; Proline; Protein Conformation; Stereoisomerism | 2014 |
Impacts of terminal (4R)-fluoroproline and (4S)-fluoroproline residues on polyproline conformation.
Topics: Amino Acid Sequence; Circular Dichroism; Fluorine; Halogenation; Kinetics; Models, Molecular; Oligopeptides; Peptides; Proline; Protein Conformation; Protein Folding; Protein Stability; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Thermodynamics | 2014 |
Applying γ-substituted prolines in the foldon peptide: polarity contradicts preorganization.
Topics: Amino Acid Sequence; Circular Dichroism; Fluorine; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proline; Protein Conformation; Protein Engineering; Protein Folding | 2015 |
Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).
Topics: 4-Aminobutyrate Transaminase; Enzyme Activation; Enzyme Inhibitors; Fluorine; Humans; Models, Molecular; Proline; Protein Conformation; Pyridoxal Phosphate | 2015 |
An organocatalytic strategy for the stereoselective synthesis of C-galactosides with fluorine at the pseudoanomeric carbon.
Topics: Aldehydes; Carbon; Catalysis; Crystallography, X-Ray; Fluorine; Galactosides; Models, Molecular; Molecular Conformation; Proline; Stereoisomerism | 2015 |
R vs. S fluoroproline ring substitution: trans/cis effects on the formation of b2 ions in gas-phase peptide fragmentation.
Topics: Fluorine; Gases; Peptides; Proline; Stereoisomerism | 2016 |
An improved
Topics: Animals; Benzamides; Benzamidines; Cattle; Fluorine; Ligands; Magnetic Resonance Spectroscopy; Proline; Protein Binding; Trypsin; Trypsin Inhibitors | 2017 |
Homochiral versus Heterochiral Trifluoromethylated Pseudoproline Containing Dipeptides: A Powerful Tool to Switch the Prolyl-Amide Bond Conformation.
Topics: Amides; Dipeptides; Fluorine; Methylation; Molecular Structure; Proline; Stereoisomerism; Thiazoles | 2017 |
Catalysis of Hydrogen-Deuterium Exchange Reactions by 4-Substituted Proline Derivatives.
Topics: Anions; Catalysis; Deuterium; Fluorine; Hydrogen; Isomerism; Ketones; Kinetics; Proline | 2019 |
Fluorine Substituted Proline Enhances the Tubulin Binding Potential of a Tetrapeptide at the GTP Binding Pocket Causing the Inhibition of Microtubule Motility and an Antimitotic Effect.
Topics: Antimitotic Agents; Binding Sites; Fluorine; Guanosine Triphosphate; Microtubules; Proline; Tubulin | 2021 |
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Design; Drug Resistance, Viral; Fluorine; Halogenation; HCV NS3-4A Protease Inhibitors; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sulfonamides; Viral Proteases | 2022 |