fimasartan and diphenyl

fimasartan has been researched along with diphenyl* in 1 studies

Other Studies

1 other study(ies) available for fimasartan and diphenyl

Article	Year
Development of 3D-QSAR CoMSIA models for 5-(biphenyl-2-yl)-1H-tetrazole derivatives as angiotensin II receptor type 1 (AT1) antagonists. Bioorganic & medicinal chemistry letters, 2013, Aug-15, Volume: 23, Issue:16 As a development strategy for backups of Fimasartan (1), a comparative molecular similarity indices analysis (CoMSIA) of a set of sixty-five 5-(biphenyl-2-yl)-1H-tetrazole derivatives has been performed to find out the pharmacophore elements for angiotensin II receptor type 1 (AT1) blockade. The most potent compound containing pyrimidin-4(3H)-one ring, Fimasartan (1) was used to align the molecules. As a result, we obtained 3D-QSAR model which provided good predictivity for both the training set (q(2)=0.846, r(2)=0.975) and the external test set (rpred(2)=0.980). This model would guide the design of backups for Fimasartan (1), a launched oral antihypertensive agent. Topics: Angiotensin II Type 2 Receptor Blockers; Biphenyl Compounds; Computer Simulation; Inhibitory Concentration 50; Models, Chemical; Pyrimidines; Quantitative Structure-Activity Relationship; Tetrazoles	2013

Article

Year

Development of 3D-QSAR CoMSIA models for 5-(biphenyl-2-yl)-1H-tetrazole derivatives as angiotensin II receptor type 1 (AT1) antagonists.

Bioorganic & medicinal chemistry letters, 2013, Aug-15, Volume: 23, Issue:16

As a development strategy for backups of Fimasartan (1), a comparative molecular similarity indices analysis (CoMSIA) of a set of sixty-five 5-(biphenyl-2-yl)-1H-tetrazole derivatives has been performed to find out the pharmacophore elements for angiotensin II receptor type 1 (AT1) blockade. The most potent compound containing pyrimidin-4(3H)-one ring, Fimasartan (1) was used to align the molecules. As a result, we obtained 3D-QSAR model which provided good predictivity for both the training set (q(2)=0.846, r(2)=0.975) and the external test set (rpred(2)=0.980). This model would guide the design of backups for Fimasartan (1), a launched oral antihypertensive agent.

Topics: Angiotensin II Type 2 Receptor Blockers; Biphenyl Compounds; Computer Simulation; Inhibitory Concentration 50; Models, Chemical; Pyrimidines; Quantitative Structure-Activity Relationship; Tetrazoles

2013